CN201139562Y - Nerve signal transfer behavior detecting device among single-neurone and multi-neurone clusters - Google Patents
Nerve signal transfer behavior detecting device among single-neurone and multi-neurone clusters Download PDFInfo
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- CN201139562Y CN201139562Y CNU2007201310087U CN200720131008U CN201139562Y CN 201139562 Y CN201139562 Y CN 201139562Y CN U2007201310087 U CNU2007201310087 U CN U2007201310087U CN 200720131008 U CN200720131008 U CN 200720131008U CN 201139562 Y CN201139562 Y CN 201139562Y
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Abstract
The utility model discloses a detecting device for the nerve signal transfer characteristic of single neuron and multiple neuron colonies, which is characterized in that the detecting device comprises electrode units with an array distribution. Each electrode unit comprises an exciting electrode and a detecting electrode, and an exciting control switch and a detecting control switch are respectively connected on the exciting electrode and the detecting electrode. Compared with the prior art, the detecting device has the advantages that the working state of each electrode point can be controlled while the number of the outward leading-out wires of the electrode can be greatly reduced, and the defects that the number of the leading-out wires is limited along with the increasing of the number of the electrode array are overcome. The detecting device can realize the microcosmic research of signal transfer characteristic among single neuron bodies, the dendrites and the neuraxons as well as among the neuron colonies.
Description
Technical field
This utility model relates to a kind of be used to the to comprise human vertebrate neuron and the research device of neuron colony electrical activity signal transmission characteristic, relates in particular to auxiliary mononeuron of a kind of microelectronics system and device for detecting nerve signal transfer characteristic between neuron clusters.
Background technology
1906, Italian scientist Ge Erji (Camillo Golgi) and Spain scientist Ramon Ka Haer (SantiagoRam ó ny Cajal) found the nervous system structure.Since oneth century, thrown oneself into the research of neuroscience, opened up the road of modern Neuroscience Research, established the basis of modern neuroscience from the thousands of scientist in a plurality of fields.From the forties in 20th century, people imitate the brain logic thoughtcast and have made up the huge computer (computer) of human social development influence, have formed generalized neutral net mathematical model theory simultaneously on the neuron conceptual foundation.Since the nineties in 20th century, people utilize microelectronics and photoelectronic advanced technology, the information of exploring loop that single neuron and neuron colony form and network from microcosmic produces, handles and the transmission ultimate principle, sets up biology nerve and physics (machine, light) the blended integrated system of information circuits; Simultaneously, set up brain science and Cognitive Science, senior cognitive function of human brain and neuromechanism thereof are carried out multidisciplinary, multi-level comprehensive study from macroscopic view.
In the world, as far back as 1972, Thomas etc. just introduced the biological activity that microelectrode array (MEA) is surveyed the cell in the cultivation.Over more than 30 year, scientist has developed the MEA of various ways, is used for the cell of cultivating that comprises neuron is carried out signal of telecommunication record and excitation.Yet these MEA are plane or the needle-like conductor site array that is produced on glass, silicon or other substrate mostly, and the microelectronics system of they and acquisition of signal and excitation is discrete.Calendar year 2001, Germany Max Planck Biochemical Research Peter Fromherz and Gunther Zeck the neuron of Limax is placed on the silicon chip that 16 excitation/record two-way function electrode positions are arranged, each electrode position surrounds with 6 micro plastic posts that prevent that neuron from moving, and is being close between the neuron and is forming interface between neuron and the silicon chip like this.They have designed a voltage stimulator under each neuron, produce a kind of whole neuronic electric pulse that runs through, and be transferred to another neuron by a neuron, turn back to silicon chip at last again, thereby understand that in neuron aspect Shanghai Stock Exchange signal can transmit by silicon-neuron-neuron-silicon loop.But because each contact site of all these MEA needs a lead-out wire, electrode number is subjected to the restriction of array lead-out wire.For example, extreme electrode number of sites/lead-out wire number of the MEA that Germany MCS company produces is 60, Max Planck Biochemical Research MEA contain 16 excitation/record two-way function electrode site, this is not enough to generate with transmission characteristic and carry out the more research of microcosmic discerning between the neuron colony signal.
Microelectric technique as the information technology basis grows continuously and fast, the characteristic size of integrated circuit has entered the nanometer stage, the scale development of circuit has arrived System on Chip/SoC (SOC) rank, and the number of transistors of CPU is more than one hundred million, single chip can the canned data amount just near people's brain.This makes us on the one hand can remove " stimulation " single fine structures such as neuronic cell space, dendron and aixs cylinder with the magnitude size with several microns microelectronic " pin " (electrodes) to tens micron-scales, the while can zero distance " observation " characteristic of electrical activity between them; Make we can with hundreds and thousands of microelectronic components go electrical activity signal in the network that " tracking " tens form to hundreds of neuron colony generation, transmit with related.
The utility model content
This utility model provides a kind of microelectronics method of utilizing, and explores the detection method and the device of nerve signal transmission characteristic between each position of single neuron and the neuron colony.
Device described in the utility model is by the following technical solutions:
A kind of mononeuron and device for detecting nerve signal transfer characteristic between neuron clusters, it is characterized in that comprising electrode unit according to array distribution, this electrode unit comprises: exciting electrode and exploring electrode are connected with the excitation gauge tap respectively and survey gauge tap on exciting electrode and exploring electrode.
The device that is used to explore nerve signal transmission characteristic between each position of single neuron and the neuron colony described in the utility model comprises having that bioelectrical signals is surveyed and microelectrode array, MOS switching network, microelectronics nerve signal exciter array and the microelectronics nerve signal detection device array of incentive functions.Microelectrode array and MOS switching network are positioned at the center of whole device, adopt the form of similar calculator storage work, the duty of each electrode points in the microelectrode array (excitation or detection) is controlled by " OK " switch in the MOS switching network and " row " switch.Each electrode points of microelectrode array can be considered as with computer storage similar one can " read " (detection) can " write " (excitation) position.Microelectronics nerve signal exciter array and microelectronics nerve signal detection device array are positioned at the periphery of microelectrode array district and MOS switching network, microelectronics nerve signal detection device adopts the shared mode of row, and microelectronics nerve signal activator adopts the shared mode of row.Cultivate neuron in the microelectrode array district, when the MOS switching network chooses certain electrode points that contacts with microstructures such as neuronic cell space, dendron or aixs cylinders to be " writing " state, signal in the microelectronics nerve signal activator is sent into micro structures such as neuronic cell space, dendron or aixs cylinder by selected electrode points, signal by neuronic these micro structures after, the electrode points that is in " reading " duty by another that contacts with it enters microelectronics nerve signal detection device and carries out processing and amplifying again.
The sniffer that is used to explore nerve signal transmission characteristic between each position of single neuron and the neuron colony described in the utility model adopts the CMOS technology of standard to realize.Between the microstructures such as single neuronic cell space, dendron and aixs cylinder that utilize this sniffer and can cultivate microelectrode array zone on the silicon chip by means of nerve signal generator, dark memory oscilloscope and microscope and the importing into of the nerve signal between a plurality of neuron colony, integration, spontaneous and bring out to generate and spread out of characteristic and conduct a research.
Compared with prior art, the utlity model has following advantage:
1) this utility model with the structure applications of similar MOS single tube read-write memory in the design of extensive electrod-array, when making the duty of each electrode points controlled, reduce the number of the outer lead-out wire of electrode pair significantly: counting for array is the electrod-array of N * N, and electrode outlet line can be from N
2Bar reduces to the 4N bar.N=32 for example, then lead-out wire will reduce to 128 from 1024.Overcome the restricted drawback of increase lead-out wire number along with the electrod-array number.
2) the designed microelectronic chip device of this utility model integrates micron order electrod-array, MOS switching network, nerve signal detection device array and the nerve signal exciter array with bioelectrical signals detection and incentive characteristic.Can realize between each structure such as single pericaryon, dendron and aixs cylinder and the microexamination of signal transfer characteristic between the neuron colony.
Description of drawings
Fig. 1 is this utility model neuron and neuron colony acquisition of signal and excitation microelectronic chip system functional block diagram.Among the figure, 2. binding line, 3.PCB, 4. electrod-array point, 5. neurocyte, 6. silicon chip, 7. lead-out wire, 8. nerve signal exciter array, 9. nerve signal detection device array, 10.MOS switching network.
Fig. 2 is this utility model microelectrode array electrode unit embodiment circuit diagram.
Fig. 3 is this utility model two dimension microelectrode array embodiment circuit diagram.
The specific embodiment
As shown in Figure 1, a kind of mononeuron and device for detecting nerve signal transfer characteristic between neuron clusters comprise extensive micron order (adapting with neuronic dendron and axon diameter) the electrod-array district with bioelectrical signals detection and incentive characteristic of employing standard CMOS process design realization and nerve signal exciter array 8 and the nerve signal detection device array 9 that MOS switching network 10, employing standard CMOS process design integrated realization.Wherein the structure of similar computer MOS single tube read-write memory is adopted in the microelectrode array design, and the electrod-array element circuit is designed to the form of the capable N row of N.Independently electrode points and two MOS switches constitute each electrode unit circuit by two.Two electrode points are respectively as exciting electrode point and detecting electrode point, and two MOS switches are controlled the duty of exciting electrode and detecting electrode respectively.Be that each electrode unit circuit is all by two MOS switches (row gauge tap and row gauge tap) control.At any one constantly, not only can realize single excitation or single detecting function, and can realize original position excitation and the function of surveying, really realize the controlled purpose of array point duty.Nerve signal detection device array 9 adopts the form of array of row electrodes units shared, nerve signal detection device array 9 is used to amplify the nerve signal that is detected from the microstructures such as neuronic cell space, dendron and aixs cylinder of contact with it by exploring electrode, and synchronization can satisfy N the electrode points of choosing simultaneously carried out acquisition of signal.Nerve signal exciter array 8 adopts the form of row electrod-array units shared, be used for nerve signal excitation is carried out in the microstructures such as pericaryon, dendron and aixs cylinder that contact with exciting electrode, synchronization can satisfy N the electrode points of choosing simultaneously carried out signal excitation.
Fig. 2 illustrates the concrete structure of electrode unit 1 in the microelectrode array, and Fig. 3 illustrates the two-dimentional microelectrode array circuit diagram based on electrode unit 1.Electrode unit 1 comprises: exciting electrode 12 and exploring electrode 14 are connected with excitation gauge tap 11 respectively and survey gauge tap 13 on exciting electrode 12 and exploring electrode 14.
Excitation gauge tap 11 adopts metal-oxide-semiconductor, and the source electrode of this metal-oxide-semiconductor is connected with exciting electrode 12, and the drain electrode of this metal-oxide-semiconductor is as pumping signal input V
i, the grid of this metal-oxide-semiconductor is as energizing switch control end V
Ic
The energizing switch control end V of each row energization gauge tap 11
IcLink to each other respectively and formation action line control end, each row is surveyed the search switch control end V of gauge tap 13
OcLink to each other and form and survey the row control end.On excitation gauge tap 11, be connected with nerve signal exciter array 8, survey on the gauge tap 13 and be connected with nerve signal detection device array 9.
Claims (5)
1. mononeuron and device for detecting nerve signal transfer characteristic between neuron clusters, it is characterized in that comprising electrode unit (1) according to array distribution, this electrode unit (1) comprising: exciting electrode (12) and exploring electrode (14) are connected with excitation gauge tap (11) respectively and survey gauge tap (13) on exciting electrode (12) and exploring electrode (14).
2. mononeuron according to claim 1 and device for detecting nerve signal transfer characteristic between neuron clusters, it is characterized in that encouraging gauge tap (11) to adopt first metal-oxide-semiconductor, the source electrode of this first metal-oxide-semiconductor is connected with exciting electrode (12), the drain electrode of first metal-oxide-semiconductor is as pumping signal input (Vi), and the grid of first metal-oxide-semiconductor is as energizing switch control end (Vic).
3. mononeuron according to claim 1 and 2 and device for detecting nerve signal transfer characteristic between neuron clusters, it is characterized in that surveying gauge tap (13) and adopt second metal-oxide-semiconductor, the drain electrode of this second metal-oxide-semiconductor is connected with exploring electrode (14), the source electrode of second metal-oxide-semiconductor is as detectable signal outfan (Vo), and the grid of second metal-oxide-semiconductor is as search switch control end (Voc).
4. mononeuron according to claim 3 and device for detecting nerve signal transfer characteristic between neuron clusters, the energizing switch control end that it is characterized in that each row energization gauge tap links to each other respectively and formation action line control end, and the search switch control end of each row detection gauge tap links to each other and the row control end is surveyed in formation.
5. mononeuron according to claim 4 and device for detecting nerve signal transfer characteristic between neuron clusters, it is characterized in that on excitation gauge tap (11), being connected with nerve signal exciter array (8), survey on the gauge tap (13) and be connected with nerve signal detection device array (9).
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| Application Number | Priority Date | Filing Date | Title |
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| CNU2007201310087U CN201139562Y (en) | 2007-12-14 | 2007-12-14 | Nerve signal transfer behavior detecting device among single-neurone and multi-neurone clusters |
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| CNU2007201310087U CN201139562Y (en) | 2007-12-14 | 2007-12-14 | Nerve signal transfer behavior detecting device among single-neurone and multi-neurone clusters |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107111783A (en) * | 2015-01-14 | 2017-08-29 | 国际商业机器公司 | Neuron memory circuitry |
| CN108309231A (en) * | 2017-01-17 | 2018-07-24 | 长庚大学 | Neural probe plate, neural evaluation system, and neural evaluation method |
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2007
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107111783A (en) * | 2015-01-14 | 2017-08-29 | 国际商业机器公司 | Neuron memory circuitry |
| CN107111783B (en) * | 2015-01-14 | 2020-04-03 | 国际商业机器公司 | Neuron memory circuit |
| CN108309231A (en) * | 2017-01-17 | 2018-07-24 | 长庚大学 | Neural probe plate, neural evaluation system, and neural evaluation method |
| CN108309231B (en) * | 2017-01-17 | 2021-09-17 | 长庚大学 | Neural probe plate, neural evaluation system, and neural evaluation method |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081029 Termination date: 20101214 |