CN201091746Y - Electroacupuncture stimulation nerve injury protecting device - Google Patents
Electroacupuncture stimulation nerve injury protecting device Download PDFInfo
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- CN201091746Y CN201091746Y CNU2007200317587U CN200720031758U CN201091746Y CN 201091746 Y CN201091746 Y CN 201091746Y CN U2007200317587 U CNU2007200317587 U CN U2007200317587U CN 200720031758 U CN200720031758 U CN 200720031758U CN 201091746 Y CN201091746 Y CN 201091746Y
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Abstract
The utility model belongs to medical electro-acupuncture equipment, in particular to a device for protecting nerve injury by electro-acupuncture stimulation, which comprises a control unit (1), a power supply unit for the control unit (1), and a pulse output unit (2) in electrical connection with the control unit (1), all of the units are fixed in a casing (14). The utility model is characterized in that the control unit (1) is electrically connected with an upper-limit frequency selection unit (7) and a lower-limit frequency selection unit (8); the control unit (1) also is electrically connected with an upper-limit frequency output time selection unit (9) and a lower-limit frequency output time selection unit (10). The medical electro-acupuncture equipment can protect and cure cerebral ischemic injury by electro-acupuncture stimulation and has excellent therapeutic effect in treatment of cerebral ischemia and prevention of sequela.
Description
Technical field
This utility model belongs to medical electro-acupuncture equipment, reaches the device of protecting and treating cerebral ischemia such as apoplexy by electroacupuncture stimulation, the device of the definite electroacupuncture stimulation neuroprotective damage of saying so.
Background technology
According to reports, the whole world accounts for the 3rd of various diseases death toll because of cerebrovascular disease (apoplexy) death toll is 4,380,000 people every year.And clinically to some treatment of diseases measure, as interventional therapy in the displacement of coronary bypass, cardiac valve, aneurysm excision and the blood vessel etc., the generation and the low perfusion state that may cause microemboli, thereby cause the cerebral ischemia injury, cause delayed ischemic neurological deficits, bring misery for society, family and patient.Therefore, cerebrovascular disease and cerebral ischemic injury how prevented and treated and important society and medical problem become.
Acupuncture gains great popularity owing to curative effect is good in cerebral ischemia treatment and sequela prevention as Chinese traditional treatment maneuver.Acusector is on the basis of needled conventionally therapy, export pulse current with electric acupuncture apparatus, after acupuncture needle thrust the acupuncture point, link to each other with the outfan of electrostimulator, parameters such as, intensity wide by the frequency, the ripple that change electricity irritation, pulse spacing produce different sensations and produce various therapeutic effect under the acupuncture point.That electrical acupuncture method has is easy and simple to handle, save manpower, safe in utilization and improve advantage such as acupuncture curative effect, use increasingly extensive at present at home and abroad.In the epoch of high-tech develop rapidly nowadays, electroacupuncture stimulation parameter (frequency, wave mode ripple are wide, current intensity, stimulation time etc.) and quantification thereof have also become an important content in the clinical and acupuncture principle research of acupuncture.A large amount of studies show that different electroacupuncture stimulation parameters have different effects to some function of body.
1. frequency Han Ji gives birth to wait to study aspect acupuncture analgesia and thinks, when adopting low-frequency pulse to stimulate (pulse current that frequency 1000Hz is following), the stimulation of different frequency is by different nervous pathways, make nervous system discharge different types of opioid peptide, act on dissimilar opiate receptors and play a role, the stimulation of its medium frequency about 2Hz causes that mainly enkephalin discharges, and the stimulation of frequency about 100Hz mainly makes the release of dynorphin increase, and they are respectively by intravital μ, δ receptor and kappa receptor mediation performance analgesic activity.Dong Hongwei etc. point out that enkephalin digestive enzyme inhibitor RB101 strengthens the low frequency electroacupuncture analgesia, and the analgesic activity of high frequency electroacupuncture is not influenced.Wang Yun observes the influence that the tolerance of different frequency (2Hz and 100Hz) acusector is transcribed kappa opioid receptor mKNA, the result shows, the different frequency acusector may have different centre effects, can cause that at the 3rd, the 6th day kappa receptor mRNA significantly reduces in the PAG as the 2Hz acusector, 100Hz does not then have obvious change.Xiong Keren etc. observe low frequency (2Hz) and great number (128Hz) acusector acupuncture rat " connected valleys " cave, demonstration different frequency acusector is respectively distinguished the influence of nitric oxide synthase expression to tail shell nuclear head, the result shows, low frequency and high frequency electroacupuncture all strengthen making tail shell nuclear head respectively distinguish nitric oxide synthase expression, and high frequency electroacupuncture is more remarkable.
2. the emerging acusector of discovering of wave mode Sun Ke is relevant with electro-acupuncture parameter to the influence of human's collateral channels and acupoints superweak luminescence intensity, and behind the dilatational wave stimulating acupoint, the long-range acupuncture point of acupoint and herbal classic luminous intensity all has increase; Behind the condensation wave stimulating acupoint, before acupoint and herbal classic long-range acupuncture point luminous intensity and the acupuncture significant difference is arranged.Thereby think that dilatational wave has excitation, promote QI-blood circulation, improve energy metabolism, similar reinforcement; Condensation wave has depression effect to nervous system, similar catharsis.
3. intensity is when the stimulus frequency of acusector is identical, and the intensity difference also can cause the difference of analgesic effect, the effect of boosting etc.Wang Yuexiu etc. observe the influence of the electro-acupuncture parameter of varying strength, different frequency to the reaction of rat spinal cord neuron nocuity, discovery is under the wide condition of identical time and ripple, the forceful electric power pin selects for use low frequency (5Hz) better, and during the light current pin to select for use high frequency (50Hz) for good.Xia Baolu etc. observe the influence to anaphylactic shock Cavia porcellus hypotension of varying strength or different frequency acusector " interior pass " cave, results suggest, and when the acusector frequency was identical, the pressor effect of high strength acusector Neiguan acupoint was better than low intensive; When acusector intensity is constant, the antianaphylaxis shock effect of high frequency electroacupuncture Neiguan acupoint significantly is better than low frequency person.
4. stimulation time observe 4 kinds of intervals of acusector (curative effect of treatment rat chronic neuropathic pain of 1 time/d, 1 time/2d, 1 time/3d and 1 time/4d), the result shows that the acupuncture frequency curative effect of 1 time/3d is best, overfrequency or the acupuncture frequency curative effect of dredging excessively are all dissatisfied.And clinical research is thought, in general the big more meaning of long more then stimulus intensity of treatment time it " rush down "; The more little meaning of short more then stimulus intensity of treatment time it " benefit ".
Can find out that from above research different electro-acupuncture parameters has different nervous physiologies and neuro chemistry mechanism.Therefore, need be under the scientific research and design prerequisite of strictness, by analysis-by-synthesis is carried out in the experiment and the clinical research of different parameters such as acusector frequency, wave mode, current intensity, stimulation time, explore electroacupuncture stimulation parameters such as more efficiently frequency, wave mode, current intensity, stimulation time or frequency, be beneficial to improve clinical efficacy, seek more efficiently Therapeutic Method.Simultaneously, for different electro-acupuncture parameters clinically have different curative effects that theoretical foundation is provided, and provide certain theoretical guidance for the selection of best electro-acupuncture parameter in the clinical practice.Wish that simultaneously the alternative parameter of various electro-acupuncture equipments also has a unified standard as much as possible.
Summary of the invention
The purpose of this utility model provides a kind of device of electroacupuncture stimulation neuroprotective damage, by the design to different parameters such as acusector frequency, wave mode, current intensity, stimulation times, makes in the prevention of cerebral ischemia treatment and sequela to reach curative effect preferably.
The technical solution of the utility model is, design a kind of device of electroacupuncture stimulation neuroprotective damage, it comprises control unit, supply with the power subsystem of control unit, the pulse output unit that control unit is electrically connected, above-mentioned each unit is fixed in the housing, it is characterized in that: control unit is electrically connected with one and selects upper limiting frequency unit and a selection lower frequency limit unit; Be electrically connected a upper limiting frequency output time selected cell and a lower frequency limit output time selected cell simultaneously.
The upper limiting frequency that described pulse output unit is selected is between 15Hz-100Hz, and the lower frequency limit of selection is between 2Hz-10Hz.
Described pulse output unit output voltage range 1v-30v, the scope 2mA-10mA of electric current.
Described pulse output unit comprises the two-stage amplifying circuit, first order amplifying circuit is the resistance R 1 that is electrically connected by with the control unit delivery outlet, the other end of R1 is electrically connected with the base stage of triode Q1, triode Q1 is the PNP pipe, the Q1 emitter stage is electrically connected with power supply, colelctor electrode is electrically connected with voltage output potential device one end, voltage output potential device other end ground connection; The centre cap of voltage output potential device is electrically connected with second level amplifying circuit, second level amplifying circuit comprises audion Q2, the resistance R 2 that is electrically connected with audion Q2 base stage, the pulse transformer that is electrically connected with audion Q2 colelctor electrode, the pulse transformer time utmost point is electrically connected two acusector moxibustion electrodes, audion Q2 grounded emitter.
The theory of Chinese medical science that is based on this utility model designs, the electric pulse of two-way different frequency is exported one tunnel frequency and is chosen between the 2Hz-10Hz, another road frequency is chosen between the 15Hz-100Hz, electric pulse output voltage range 1v-30v, and the scope of electric current is at 2mA-10mA.Regulating frequency, voltage or electric current are to influence the key factor that generation pin effect mechanism was imitated and changed to pin, the reaction that the stimulating factor that the different stimulated parameter of acusector is comprised causes with and response mechanism may be different, different combinations also may have influence on the effect of acupuncture between the various parameters.
Description of drawings
The utility model is described in further detail below in conjunction with the embodiment accompanying drawing.
Fig. 1 is this utility model embodiment circuit diagram;
Fig. 2 is this utility model example structure sketch map.
Among the figure: 1, control unit; 2, pulse output unit; 3, display unit; 4, mains transformer; 5, rectification circuit; 6, mu balanced circuit; 7, select the upper limiting frequency unit; 8, select the lower frequency limit unit; 9, upper limiting frequency output time selected cell; 10, lower frequency limit output time selected cell; 11, pulse output lead; 12, voltage output potential device; 13, frequency time regulator potentiometer; 14, housing.
The specific embodiment
As shown in Figure 1; the device of electroacupuncture stimulation neuroprotective damage comprises control unit 1; the power subsystem of supplying with control unit 1 adopts rectification circuit 5 and mu balanced circuit 6 commonly used; mains transformer 4 will exchange 220v and convert low pressure to; convert DC voltage again to by rectification circuit 5, carry out voltage stabilizing by mu balanced circuit 6 at last and offer control unit 1 and other circuit.An I/O mouth of control unit 1 is electrically connected pulse output unit 2.Pulse output unit 2 comprises the two-stage amplifying circuit, first order amplifying circuit is the resistance R 1 that is electrically connected by with control unit 1 delivery outlet, the other end of R1 is electrically connected with the base stage of triode Q1, triode Q1 is the PNP pipe, the Q1 emitter stage is electrically connected with power supply, colelctor electrode is electrically connected with voltage output potential device 12 1 ends, voltage output potential device 12 other end ground connection; The centre cap of voltage output potential device 12 is electrically connected with second level amplifying circuit, second level amplifying circuit comprises audion Q2, the resistance R 2 that is electrically connected with audion Q2 base stage, the pulse transformer that is electrically connected with audion Q2 colelctor electrode, the pulse transformer time utmost point is electrically connected two acusector moxibustion electrodes, audion Q2 grounded emitter.Electric pulse output voltage range 1v-30v, the scope of electric current is at 2mA-10mA.The output voltage of pulse output unit 2 and electric current are to regulate output by voltage output potential device 12.
As shown in Figure 2, above-mentioned circuit is regularly in the housing 14, select upper limiting frequency unit 7, select lower frequency limit unit 8, upper limiting frequency output time selected cell 9, lower frequency limit output time selected cell 10 and regulating frequency time regulator potentiometer 13, voltage output potential device 12 to be fixed on the front panel, 2 two electrode A of pulse output unit, A end are drawn by pulse output lead 11, are fixed on human acupoint.
Provide the situation that adopts the foregoing circuit experiment below, further specify benefit of the present utility model.
(1). the selection of electroacupuncture stimulation parameter
Select electrical stimulation parameters-waveform (continuous wave, discontinuity wave, dilatational wave), current intensity (1mA, 2mA, 3mA), frequency (2Hz-100Hz decides according to waveform) makes up, and is nested designs (seeing Table 1).
Table 1 electroacupuncture stimulation condition nested designs scheme
(2). laboratory animal and grouping:
Laboratory animal is provided by The Fourth Military Medical University's Experimental Animal Center.Cleaning level male SD rat (280g-320g) 210.210 SD rats are divided into 35 groups (every group=6) at random, are respectively blank group, pentobarbital sodium group (PB), acusector group: a continuous wave: 1mA+2Hz, 1mA+15Hz, 1mA+30Hz, 1mA+100Hz, 2mA+2Hz, 2mA+15Hz, 2mA+30Hz, 2mA+100Hz, 3mA+2Hz, 3mA+15Hz, 3mA+30Hz, 3mA+100Hz.
B, discontinuity wave: 1mA+2/0Hz, 1mA+15/0Hz, 1mA+30/0Hz, 1mA+100/0Hz, 2mA+2/0Hz, 2mA+15/0Hz, 2mA+30/0Hz, 2mA+100/0Hz, 3mA+2/0Hz, 3mA+15/0Hz, 3mA+30/0Hz, 3mA+100/0Hz.
C, dilatational wave: 1mA+2/15Hz, 1mA+2/30Hz, 1mA+2/100Hz, 2mA+2/15Hz, 2mA+2/30Hz, 2mA+2/100Hz, 3mA+2/15Hz, 3mA+2/30Hz, 3mA+2/100Hz.
(3). acusector is handled
The acusector group is with reference to " subject of experimental acupuncture and moxibustion "
[100]Common experimental animal acupoint, at location, parietal bone center Baihui acupoint, with No. 30 0.5 flat forward thorn 2mm of acupuncture needle, another electrode that forms the loop with Baihui acupoint is sandwiched on the ear of rat right side, connect electric acupuncture device (WQ-10D1 type, Haidian, Beijing Electronic Instruments Plant), be the acupoint stimulation efficiency index with little the quivering of rat auris dextra.Blank group intraperitoneal injection of saline every day 4mL/kg/d, continuous 5 days; Pentobarbital sodium group and acusector group lumbar injection every day 1% pentobarbital sodium 40mg/kg/d, continuous 5 days, the pentobarbital sodium group is surplus not to process, and each group of acusector accepts to stimulate 30min/d, continuous 5 days according to relevant parameter.
(4) cerebral ischemic model (MCAO) is closed in the middle cerebral artery resistance
Fasting 12h before the animal art can't help water.Animal gives 4%Iso induced anesthesia by face shield, and 2%Iso sucks and keeps depth of anesthesia, keeps autonomous respiration.The MCAO model is according to the method for Koizumi etc.
[101]Get the neck median incision behind the rat anesthesia, expose right carotid, external carotid artery and internal carotid artery, ligation common carotid artery, external carotid artery, cut a kerf in common carotid artery bifurcated below, an end is burnt till nylon wire (3-0, the Ethicon Inc of round end with alcohol burner, Japan) insert internal carotid artery 17～18mm, the ligation internal carotid artery.Extract nylon wire out after 120min is closed in resistance, recover perfusion again.(Spacelab, America) monitoring maintains 37 ℃～37.5 ℃ with roasting lamp to body temperature by anus temperature probe connection multifunctional monitoring instrument in the art.
(5). animal recovers and function of nervous system's infringement assessment
Behind the recovery from anesthesia, animal is put back to mouse cage, free diet.24h behind the cerebral ischemia re-pouring is marked by observer's evaluate recorded nervous lesion of not understanding the grouping situation, and method is 6 grades of point systems: 0 grade, and no dysfunction; 1 grade, not tensible left side forelimb; 2 grades, rotation to the left; 3 grades, topple over to the left; 4 grades, no autonomic activities companion disturbance of consciousness; 5 grades, death.
(6). the cerebral infarction kitchen range is measured
Pour into again after 24h nervous lesion scoring finishes, animal with the ketamine deep anaesthesia after sacrificed by decapitation, open skull rapidly with rongeur, cut off meninges, complete taking-up Mus brain is put into-20 ℃ of brine ices immediately.Take out the Mus brain behind the 10min, place special Mus brain groove, get coronalplane and evenly be cut into the thick brain sheet of 2mm, totally 6.The brain sheet is put into 2%TTC solution rapidly, 37 ℃ of water-bath 30min are to colour developing, be kept in 4% paraformaldehyde, use digital camera (KODAK after 24 hours, DC240USA) the back input computer of taking pictures, (pink zone is a normal cerebral tissue to calculate infarct size with image processing software (ADOBE, PHOTOSHOP 6.0), white area is an infarcted region), each brain sheet infarct size sum multiply by thickness (2mm) as the cerebral infarction volume.
Comparative result between all combinations: do not have difference (P=0.940) between blank group and pentobarbital sodium group infarction volume.33 acusector groups respectively with blank group infarction volumetric ratio, remove continuous wave 1mA+30Hz, 2mA+30Hz, 1mA+100Hz, 2mA+100Hz, 3mA+100Hz, discontinuity wave 1mA+100/0Hz, 2mA+100/0Hz, 3mA+100/0Hz compares outside the no difference of science of statistics with blank group, and all the other all have significant difference (table 2).
Each stimulus parameter comparative result: do not have significant difference (P=0.3657) between three kinds of current intensity (1mA, 2mA, 3mA).Obvious significant difference (P=0.004) is arranged between three kinds of waveforms; Dilatational wave and continuous wave and discontinuity wave more variant (the P value is all less than 0.000), continuous wave and discontinuity wave more also have significant difference, but not obvious (P=0.49).Significant difference obvious (P＜0.0001) between each frequency.
Experimental result shows that the pretreatment protective effect of different frequency and waveform generation is variant, and no significant difference between the stimulation of 1-3mA current intensity proves that frequency and waveform are even more important stimulus parameters with respect to current intensity.The brain protective effect of dilatational wave is the most obvious, and discontinuity wave takes second place, and continuous wave is relatively poor.This may make easily with continuous wave stimulates object relevant to stimulating generation to tolerate, and dilatational wave can stimulate different types of neurochemical to discharge by the conversion of basic, normal, high frequency, produces neuroprotective by different approaches at different target spots.This research finds that also frequency is the electroacupuncture stimulation of 100Hz, no matter is continuous wave (100Hz), or discontinuity wave (100/0Hz), all fails to induce the cerebral ischemia tolerance and the generation cerebral protection.Frequency is that the dilatational wave of 2/15Hz, 2/30Hz and continuous wave that frequency is 2Hz then can induce the cerebral ischemia tolerance to produce good brain protective effect.This experimental result shows that the protective effect of 2Hz electroacupuncture stimulation is more obvious, and the electroacupuncture stimulation of 100Hz does not then show protective effect.
In a word; the inventor finds to repeat the acusector moxibustion first, and (frequency is the dilatational wave of 2/15Hz; 30min/d; continuous 5 days) the stimulation in rats Baihui acupoint can simulate ischemia pretreatment effect, and the cerebral ischemia that (24h after the last pretreatment) rat transience MCAO causes to subsequently has significant protective effect.Find that first acusector moxibustion repetitive stimulation rat Baihui acupoint can induce cerebral ischemia tolerance effect, stimulus waveform and frequency are even more important stimulus parameters.Frequency is the strongest by the inductive cerebral ischemia tolerance of the dilatational wave electroacupuncture stimulation of rarefaction wave 2Hz, condensation wave 15Hz-30Hz effect, and the frequency stimulation of 100Hz does not then have this effect.
Claims (4)
1. the device of electroacupuncture stimulation neuroprotective damage, it comprises control unit (1), supply with the power subsystem of control unit (1), the pulse output unit (2) that control unit (1) is electrically connected, above-mentioned each unit is fixed in the housing (14), it is characterized in that: control unit (1) is electrically connected with one and selects upper limiting frequency unit (7) and a selection lower frequency limit unit (8); Be electrically connected a upper limiting frequency output time selected cell (9) and a lower frequency limit output time selected cell (10) simultaneously.
2. the device of electroacupuncture stimulation neuroprotective damage according to claim 1 is characterized in that: the upper limiting frequency that described pulse output unit (2) is selected is between 15Hz-100Hz, and the lower frequency limit of selection is between 2Hz-10Hz.
3. the device of electroacupuncture stimulation neuroprotective damage according to claim 1 is characterized in that: described pulse output unit (2) output voltage range 1v-30v, the scope 2mA-10mA of electric current.
4. the device of electroacupuncture stimulation neuroprotective damage according to claim 1, it is characterized in that: described pulse output unit (2) comprises the two-stage amplifying circuit, first order amplifying circuit is the resistance R 1 that is electrically connected by with control unit (1) delivery outlet, the other end of R1 is electrically connected with the base stage of triode Q1, triode Q1 is the PNP pipe, the Q1 emitter stage is electrically connected with power supply, and colelctor electrode is electrically connected with voltage output potential device (12) one ends, voltage output potential device (12) other end ground connection; The centre cap of voltage output potential device (12) is electrically connected with second level amplifying circuit, second level amplifying circuit comprises audion Q2, the resistance R 2 that is electrically connected with audion Q2 base stage, the pulse transformer that is electrically connected with audion Q2 colelctor electrode, the pulse transformer time utmost point is electrically connected two acusector moxibustion electrodes, audion Q2 grounded emitter.
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| CNU2007200317587U CN201091746Y (en) | 2007-05-10 | 2007-05-10 | Electroacupuncture stimulation nerve injury protecting device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109182270A (en) * | 2018-09-14 | 2019-01-11 | 南通市第人民医院 | A kind of acusector induction abducent nerve M2 type microglia polarization method |
| CN111481438A (en) * | 2020-04-23 | 2020-08-04 | 四川大学华西医院 | Electric acupuncture instrument for treating cerebral hemorrhage secondary nerve injury |
| CN112640839A (en) * | 2019-10-10 | 2021-04-13 | 上海市浦东医院（复旦大学附属浦东医院） | Establishing method and application of yang death syndrome animal model |
| CN113307110A (en) * | 2021-06-02 | 2021-08-27 | 广州相佳数码科技有限公司 | Electric acupuncture instrument with wire winding function |
-
2007
- 2007-05-10 CN CNU2007200317587U patent/CN201091746Y/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109182270A (en) * | 2018-09-14 | 2019-01-11 | 南通市第人民医院 | A kind of acusector induction abducent nerve M2 type microglia polarization method |
| CN112640839A (en) * | 2019-10-10 | 2021-04-13 | 上海市浦东医院（复旦大学附属浦东医院） | Establishing method and application of yang death syndrome animal model |
| CN112640839B (en) * | 2019-10-10 | 2023-12-29 | 上海市浦东医院（复旦大学附属浦东医院） | Method for establishing animal model with yang-depletion syndrome and application thereof |
| CN111481438A (en) * | 2020-04-23 | 2020-08-04 | 四川大学华西医院 | Electric acupuncture instrument for treating cerebral hemorrhage secondary nerve injury |
| CN113307110A (en) * | 2021-06-02 | 2021-08-27 | 广州相佳数码科技有限公司 | Electric acupuncture instrument with wire winding function |
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Granted publication date: 20080730 Termination date: 20120510 |