CN201030138Y - Degradable medicine releasing electron capsule - Google Patents
Degradable medicine releasing electron capsule Download PDFInfo
- Publication number
- CN201030138Y CN201030138Y CNU2006201120497U CN200620112049U CN201030138Y CN 201030138 Y CN201030138 Y CN 201030138Y CN U2006201120497 U CNU2006201120497 U CN U2006201120497U CN 200620112049 U CN200620112049 U CN 200620112049U CN 201030138 Y CN201030138 Y CN 201030138Y
- Authority
- CN
- China
- Prior art keywords
- shell
- driving mechanism
- capsule
- degradable
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Disclosed is a degradable drug releasing electronic capsule, which relates to a device for releasing drug to alimentary canal. The degradable drug releasing electronic capsule is utilized for distant controlling to release substance, such as drug, food, markers and the like to alimentary canals of animals or human bodies. The degradable drug releasing electronic capsule of the utility model comprises a capsule casing, an actuating mechanism, a drug core and a drug releasing channel mechanism. One end of the drug core comprises a raised mechanism, which can open the drug releasing channel mechanism under the function of actuating force. The capsule casing comprises a casing support bracket and a casing coating, wherein the casing support bracket can be dissolved or decomposed by alimentary canal liquid, and the casing coating produced by material which can not be dissolved or decomposed by alimentary canal liquid is evenly coated outside the casing support bracket. The degradable drug releasing electronic capsule of the utility model has a degradable casing, which enhances clinical safety of products, with simple structure, easy mass production and great practicability.
Description
Technical field:
This utility model relates to a kind of degradable medicine releasing capsule, and particularly a kind of device that discharges medicine in digestive tract is used for the digestive tract remote control h substance at animal or human's body, as medicine, food, label etc.
Background technology:
Medicine releasing capsule is a kind of drug delivery system based on the micromechanics electronic technology, can be by external remote control, and the control medicine has excellent application value in gastral release time and off-position aspect clinical treatment, the medicine digestive tract Absorption Study.In Chinese patent CN1600279A, among the CN1209997B, the scheme of medicine releasing capsule is all disclosed.The shell of present medicine releasing capsule is general to adopt material such as plastics with good biocompatibility or rustless steel to form, its common feature is to have good intensity, corrosion-resistant, promptly can not in digestive tract, degrade, this class shell can be guaranteed the electronic devices and components discord digestive tract liquid contact in the electronic capsule, has good biological safety.But, the problem that current technical scheme exists is: electronic capsule is in by whole gastral process, its profile is constant, electronic capsule can be swallowed and do not meant that capsule can be discharged smoothly, in case electronic capsule has taken place to block in the intestinal somewhere, often can only electronic capsule be taken out, even need take out by laparotomy ventrotomy by the method for operation, therefore, current technical scheme exists bigger clinical application risk.
The utility model content:
The purpose of this utility model is to overcome the deficiencies in the prior art, and a kind of have higher clinical safety, degradable medicine releasing capsule are provided.
The technical solution of the utility model is: a kind of degradable medicine releasing capsule, comprise capsule shell, driving mechanism, the medicine label, the drug release passage mechanism, medicine label one end comprises protrusion means, protrusion means can be opened the drug release passage mechanism under the driving force effect, described capsule shell comprises outer casing stand, shell coating, outer casing stand can be dissolved by digestive tract liquid or decompose, the shell coating material forms for the material that can not be dissolved by digestive tract liquid or decompose, evenly be coated on outside the outer casing stand, driving mechanism comprises the driving mechanism shell, removable sealing mechanism, removable sealing mechanism and driving mechanism shell constitute airtight storehouse, removable sealing mechanism closely contacts with the medicine label, the driving force of driving mechanism puts on the removable sealing mechanism, removable sealing mechanism promotes the medicine label to the motion of drug release passage mechanism, and protrusion means is opened the drug release passage mechanism under the driving force effect.
Described shell coating material is the paraffin of medical grade, and the thickness of shell coating is 0.1-0.5mm.
Described removable sealing mechanism can be a piston, the inwall formation of piston and driving mechanism shell is slidingly matched, the inwall front end of driving mechanism shell has the protruding round platform towards cylinder axis, when moving to the end of driving mechanism shell under the effect of piston at driving force, described protruding round platform can stop the further motion of piston.
Described removable sealing mechanism also can comprise an elastic film, drive plate, elastic film and driving mechanism shell constitute sealing, drive plate is positioned at the driving mechanism enclosure, fixedly connected with elastic film, before drug release, the fixed mechanism that can disconnect is fixed drive plate, makes elastic film be in extended state, and an end of the elastic film of extended state and medicine label closely contacts.
Described removable sealing mechanism can comprise an elastic bellows, drive plate, one end of elastic bellows is airtight, elastic bellows and driving mechanism shell constitute sealing, drive plate is positioned at the driving mechanism enclosure, fixedly connected with the sealed end of elastic bellows, before drug release, the fixed mechanism that can disconnect is fixed drive plate, make elastic bellows be in compressive state, an end of the elastic bellows of compressive state and medicine label closely contacts.
Operation principle of the present utility model is: after described remote controlled modicine reliesing electronic capsule is swallowed and is entered digestive tract, because the shell coating of capsule shell is can not be by the material of digestive tract liquid disintegrate, therefore, the maintenance shape invariance of capsule shell; After the control circuit in the driving mechanism receives the external drug release remote controlled signal that sends, energized, driving mechanism produces a driving force, the driving force of driving mechanism puts on the removable sealing mechanism, removable sealing mechanism promotes the medicine label and moves to the drug release passage mechanism, protrusion means is opened the drug release passage mechanism under the driving force effect, drug release begins.The medicine label contacts with digestive tract liquid, processes such as the medicine label dissolves, decomposition, and drug release gone into digestive tract, disintegrate along with the medicine label, digestive tract liquid enters the inside of capsule shell by the release through hole, because the outer casing stand of capsule shell is to be formed by the material of digestive tract liquid disintegrate, therefore, outer casing stand is by disintegrate gradually; Counting the disintegrate of outer casing stand, shell coating has lost the support of outer casing stand, and under the effect of intestinal peristalsis promoting power, shell coating is destroyed, caves in, rupture process, and capsule shell is degraded gradually.Because driving mechanism shell and removable sealing mechanism have constituted airtight storehouse, digestive tract liquid can not contact with the electronic devices and components in the driving mechanism, has guaranteed the biocompatibility of electronic capsule simultaneously.
This utility model compared with prior art has following technique effect:
1. the shell of remote controlled modicine reliesing electronic capsule of the present utility model can be degraded, and has improved the clinical safety that product uses.
2. simple in structure, be easy to produce in batches, have good practicality.
Description of drawings:
Fig. 1 is the structural representation of degradable medicine releasing capsule of the present utility model.
Fig. 2 is the drug release process sketch map of degradable medicine releasing capsule of the present utility model.
Fig. 3 is the structural representation of finishing most of drug release of degradable medicine releasing capsule of the present utility model.
Fig. 4 is the process sketch map that the outer casing stand of degradable medicine releasing capsule of the present utility model begins disintegrate.
Fig. 5 is the shell degradation process sketch map of degradable medicine releasing capsule of the present utility model.
Fig. 6 is the process sketch map that the shell major part of degradable medicine releasing capsule of the present utility model is degraded.
Fig. 7 is the structural representation that comprises the degradable medicine releasing capsule of elastic film.
Fig. 8 is the release medicine process sketch map that comprises the degradable medicine releasing capsule of elastic film.
Fig. 9 is the structural representation that comprises the degradable medicine releasing capsule of elastic bellows.
Figure 10 is the release medicine process sketch map that comprises the degradable medicine releasing capsule of elastic bellows.
In Fig. 1 to Figure 10:
1-capsule shell, 2-medicine label, 3-protrusion means, 4-release through hole, 5-sealing-plug,
6-outer casing stand, 7-shell coating, 8-driving mechanism shell, 9-piston, 10-protruding round platform,
The 11-battery, 12 control circuits, the 13-heating resistor, 14-nylon wire, 15-spring,
16-intestinal, 17-elastic film, 18-drive plate, 19-elastic bellows
The specific embodiment:
Embodiment 1:
Present embodiment provides a kind of degradable medicine releasing capsule, comprises capsule shell 1, driving mechanism, medicine label 2, drug release passage mechanism, and the drug release passage mechanism comprises release through hole 4 and sealing-plug 5.Medicine label 2 one ends comprise protrusion means 3, protrusion means 3 can be opened the drug release passage mechanism under the driving force effect, described capsule shell 1 comprises outer casing stand 6, shell coating 7, outer casing stand 6 can be dissolved by digestive tract liquid or decompose, shell coating 7 evenly is coated on outside the outer casing stand 6 for the material that can not be dissolved by digestive tract liquid or decompose forms.The shell coating material is the paraffin of medical grade in the present embodiment, and the thickness of shell coating is 0.3mm.
Driving mechanism comprises driving mechanism shell 8 and removable sealing mechanism, described removable sealing mechanism is a piston 9, the inwall formation of piston 9 and driving mechanism shell 8 is slidingly matched and constitutes airtight, the inwall front end of driving mechanism shell 8 has the protruding round platform 10 towards cylinder axis, when moving to the end of driving mechanism shell 8 under the effect of piston 9 at driving force, described protruding round platform 10 can stop the further motion of piston 9.
Fig. 1 is the structural representation of the degradable medicine releasing capsule of present embodiment.
Present embodiment remote controlled modicine reliesing electronic capsule swallow enter digestive tract after because the shell coating 7 of capsule shell is can not be by the material of digestive tract liquid disintegrate, therefore, the maintenance shape invariance of capsule shell; After the control circuit in the driving mechanism 12 received the external drug release remote controlled signal that sends, heating resistor 13 and battery 11 circuit were connected, and heating resistor 13 temperature raise, quick fuse nylon wire 14, and compression spring 15 is released, and produces driving force.The driving force that spring 15 produces puts on the piston 9, and piston 9 promotes medicine label 2 to 4 motions of release through hole, and protrusion means 3 is released sealing-plug 5.After sealing-plug 5 broke away from, medicine label 2 contacted with digestive tract liquid, processes such as medicine label 2 dissolves, decomposition, and drug release gone into digestive tract 16.
Fig. 2 is the drug release process sketch map of the degradable medicine releasing capsule of present embodiment.
Fig. 3 is the structural representation of finishing most of drug release of the degradable medicine releasing capsule of present embodiment.
Along with the disintegrate of medicine label 2, digestive tract liquid enters the inside of capsule shell 1 by release through hole 4, because the outer casing stand 6 of capsule shell is to be formed by the material of digestive tract liquid disintegrate, therefore, outer casing stand 6 is by disintegrates gradually; Counting the disintegrate of outer casing stand 6, shell coating 7 has lost the support of outer casing stand 6, and under the effect of intestinal peristalsis promoting power, shell coating 7 is destroyed, caves in, rupture process, and capsule shell 1 is degraded gradually.Because driving mechanism shell 8 and piston 9 have constituted airtight storehouse, digestive tract liquid can not contact with the electronic devices and components in the driving mechanism, has guaranteed the biocompatibility of electronic capsule simultaneously.
Fig. 4 is the process sketch map that the outer casing stand of the degradable medicine releasing capsule of present embodiment begins disintegrate.
Fig. 5 is the shell degradation process sketch map of the degradable medicine releasing capsule of present embodiment.
Fig. 6 is the process sketch map that the shell major part of the degradable medicine releasing capsule of present embodiment is degraded.
Embodiment 2:
A kind of degradable medicine releasing capsule comprises capsule shell 1, driving mechanism, medicine label 2, drug release passage mechanism, and the drug release passage mechanism comprises release through hole 4 and sealing-plug 5.Medicine label 2 one ends comprise protrusion means 3, protrusion means 3 can be opened the drug release passage mechanism under the driving force effect, described capsule shell 1 comprises outer casing stand 6, shell coating 7, outer casing stand 6 can be dissolved by digestive tract liquid or decompose, shell coating 7 evenly is coated on outside the outer casing stand 6 for the material that can not be dissolved by digestive tract liquid or decompose forms.The shell coating material is the paraffin of medical grade in the present embodiment, and the thickness of shell coating is 0.25mm.
Driving mechanism comprises driving mechanism shell 8 and removable sealing mechanism, described removable sealing mechanism comprises an elastic film 17, drive plate 18, elastic film 17 and driving mechanism shell 8 constitute sealing, and drive plate 18 is positioned at driving mechanism shell 8 inside, fixedlys connected with elastic film 17.
Present embodiment remote controlled modicine reliesing electronic capsule swallow enter digestive tract after because the shell coating 7 of capsule shell is can not be by the material of digestive tract liquid disintegrate, therefore, the maintenance shape invariance of capsule shell; After the control circuit in the driving mechanism 12 receives the external drug release remote controlled signal that sends, heating resistor 13 and battery 11 circuit are connected, and heating resistor 13 temperature raise, quick fuse nylon wire 14, the elastic film 17 that is in extended state is released, and produces driving force.The driving force that elastic film 17 produces promotes medicine label 2 to 4 motions of release through hole, and protrusion means 3 is released sealing-plug 5.After sealing-plug 5 broke away from, medicine label 2 contacted with digestive tract liquid, processes such as medicine label 2 dissolves, decomposition, and drug release gone into digestive tract 16.
Fig. 7 is the structural representation of the degradable medicine releasing capsule of present embodiment.
Fig. 8 is the release medicine process sketch map of the degradable medicine releasing capsule of present embodiment.
The degradation principles and the process of the capsule shell 1 of present embodiment are identical with embodiment 1.No longer be described in detail herein.
Embodiment 3:
A kind of degradable medicine releasing capsule comprises capsule shell 1, driving mechanism, medicine label 2, drug release passage mechanism, and the drug release passage mechanism comprises release through hole 4 and sealing-plug 5.Medicine label 2 one ends comprise protrusion means 3, protrusion means 3 can be opened the drug release passage mechanism under the driving force effect, described capsule shell 1 comprises outer casing stand 6, shell coating 7, outer casing stand 6 can be dissolved by digestive tract liquid or decompose, shell coating 7 evenly is coated on outside the outer casing stand 6 for the material that can not be dissolved by digestive tract liquid or decompose forms.The shell coating material is the paraffin of medical grade in the present embodiment, and the thickness of shell coating is 0.4mm.
Driving mechanism comprises driving mechanism shell 8 and removable sealing mechanism, described removable sealing mechanism comprises an elastic bellows 19, drive plate 18, one end of elastic bellows 19 is airtight, and drive plate 18 is positioned at driving mechanism shell 8 inside, fixedlys connected with the sealed end of elastic bellows 19.
Present embodiment remote controlled modicine reliesing electronic capsule swallow enter digestive tract after because the shell coating 7 of capsule shell is can not be by the material of digestive tract liquid disintegrate, therefore, the maintenance shape invariance of capsule shell; After the control circuit in the driving mechanism 12 receives the external drug release remote controlled signal that sends, heating resistor 13 and battery 11 circuit are connected, and heating resistor 13 temperature raise, quick fuse nylon wire 14, the elastic bellows 19 that is in compressive state is released, and produces driving force.The driving force that elastic bellows 19 produces promotes medicine label 2 to 4 motions of release through hole, and protrusion means 3 is released sealing-plug 5.After sealing-plug 5 broke away from, medicine label 2 contacted with digestive tract liquid, processes such as medicine label 2 dissolves, decomposition, and drug release gone into digestive tract 16.
Fig. 9 is the structural representation of the degradable medicine releasing capsule of present embodiment.
Figure 10 is the release medicine process sketch map of the degradable medicine releasing capsule of present embodiment.
The degradation principles and the process of the capsule shell 1 of present embodiment are identical with embodiment 1.No longer be described in detail herein.
Claims (5)
1. degradable medicine releasing capsule, comprise capsule shell, driving mechanism, the medicine label, the drug release passage mechanism, medicine label one end comprises protrusion means, protrusion means can be opened the drug release passage mechanism under the driving force effect, it is characterized in that capsule shell comprises outer casing stand, shell coating, outer casing stand can be dissolved by digestive tract liquid or decompose, the shell coating material forms for the material that can not be dissolved by digestive tract liquid or decompose, evenly be coated on outside the outer casing stand, driving mechanism comprises the driving mechanism shell, removable sealing mechanism, removable sealing mechanism and driving mechanism shell constitute airtight storehouse, removable sealing mechanism closely contacts with the medicine label, the driving force of driving mechanism puts on the removable sealing mechanism, removable sealing mechanism promotes the medicine label to the motion of drug release passage mechanism, and protrusion means is opened the drug release passage mechanism under the driving force effect.
2. degradable medicine releasing capsule according to claim 1 is characterized in that described shell coating material is the paraffin of medical grade, and the thickness of shell coating is 0.1-0.5mm.
3. degradable medicine releasing capsule according to claim 1, it is characterized in that described removable sealing mechanism is a piston, the inwall formation of piston and driving mechanism shell is slidingly matched, the inwall front end of driving mechanism shell has the protruding round platform towards cylinder axis, when moving to the end of driving mechanism shell under the effect of piston at driving force, described protruding round platform can stop the further motion of piston.
4. degradable medicine releasing capsule according to claim 1, it is characterized in that described removable sealing mechanism comprises an elastic film, drive plate, elastic film and driving mechanism shell constitute sealing, drive plate is positioned at the driving mechanism enclosure, fixedly connected with elastic film, before drug release, the fixed mechanism that can disconnect is fixed drive plate, make elastic film be in extended state, an end of the elastic film of extended state and medicine label closely contacts.
5. degradable medicine releasing capsule according to claim 1, it is characterized in that described removable sealing mechanism comprises an elastic bellows, drive plate, one end of elastic bellows is airtight, elastic bellows and driving mechanism shell constitute sealing, drive plate is positioned at the driving mechanism enclosure, fixedly connected with the sealed end of elastic bellows, before drug release, the fixed mechanism that can disconnect is fixed drive plate, make elastic bellows be in compressive state, an end of the elastic bellows of compressive state and medicine label closely contacts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2006201120497U CN201030138Y (en) | 2006-12-26 | 2006-12-26 | Degradable medicine releasing electron capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2006201120497U CN201030138Y (en) | 2006-12-26 | 2006-12-26 | Degradable medicine releasing electron capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201030138Y true CN201030138Y (en) | 2008-03-05 |
Family
ID=39162033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2006201120497U Expired - Fee Related CN201030138Y (en) | 2006-12-26 | 2006-12-26 | Degradable medicine releasing electron capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201030138Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030342A (en) * | 2015-09-01 | 2015-11-11 | 济南华奥医药科技有限公司 | Robot capsule |
-
2006
- 2006-12-26 CN CNU2006201120497U patent/CN201030138Y/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030342A (en) * | 2015-09-01 | 2015-11-11 | 济南华奥医药科技有限公司 | Robot capsule |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100482294C (en) | Remote controlled modicine reliesing electronic capsule capable of partly degradation | |
| FI82600C (en) | Aggregate with delayed action and process for its preparation | |
| KR101611240B1 (en) | Controlled activation ingestible identifier | |
| AU2016365123B2 (en) | Medicine delivery and animal management systems | |
| RU2014104693A (en) | COMMUNICATION SYSTEM PLACED IN A POISONED PRODUCT | |
| EP2967431B1 (en) | Sampling device | |
| CN100482293C (en) | Slow release type remote controlled electronic capsule | |
| CN105705194A (en) | Delivery of functionalized particles | |
| CN101489517A (en) | Warning system for timely administration of drugs that have to be administered at certain times | |
| CN200984246Y (en) | Remote-controlled medicine releasing device in enteron | |
| CN201030138Y (en) | Degradable medicine releasing electron capsule | |
| CN100588378C (en) | Alimentary tract drug release remote controlled capsule system | |
| AU2010339813A1 (en) | Tethering capsule system | |
| CN1304070C (en) | Device for releasing medication for alimentary tract at fixed point | |
| Cui et al. | The study of a remote-controlled gastrointestinal drug delivery and sampling system | |
| CN108577061A (en) | A kind of Intelligent bracelet, bracelet intelligent interactive system and its working method | |
| CN201029953Y (en) | Sustained-release electric capsule | |
| CN207822130U (en) | A kind of automatic drug taking device based on microcontroller and stepper motor | |
| CN206641973U (en) | A kind of contraceptive and medical contraception apparatus | |
| CN100438937C (en) | Mini medicine releasing device | |
| CN2628077Y (en) | Swallowable micro-releasing device | |
| US11020576B2 (en) | Medicine delivery and animal management systems | |
| CN212118344U (en) | Animal doctor throws feeder with animal remedy | |
| Aslam | Ingestible electronically controlled drug-capsule in the gut | |
| US20240149031A1 (en) | Oral drug delivery device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |