CN1994527A - Desiccant applied in active bacteria formulation and preparation method thereof - Google Patents
Desiccant applied in active bacteria formulation and preparation method thereof Download PDFInfo
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- CN1994527A CN1994527A CN 200610168740 CN200610168740A CN1994527A CN 1994527 A CN1994527 A CN 1994527A CN 200610168740 CN200610168740 CN 200610168740 CN 200610168740 A CN200610168740 A CN 200610168740A CN 1994527 A CN1994527 A CN 1994527A
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Abstract
The invention relates to a drying agent used in viable bacteria agent, and relative production, wherein it is formed by molecule screen and silica gel at 1-5:1-8 ration. It is prepared by mixing silica gel and molecule screen, with better adsorption and wide application.
Description
Technical field
The present invention relates to drier and preparation method thereof, particularly relate to a kind of drier that can be applicable to active bacteria formulation and preparation method thereof.
Background technology
Drier is a kind of deicer that absorbs moisture from atmosphere, and its drying principles is exactly hydrone to be adsorbed in self the structure or by chemical mode by physics mode to absorb hydrone and change its chemical constitution, becomes another material.At present, commercially available desiccant product is varied, and silica-gel desiccant and molecular sieve desiccant are two kinds of major products wherein:
Silica-gel desiccant: main component is a silica, processes granular or pearl by natural minerals through purifying.As drier, its microcellular structure (average out to 2A) has good affinity to hydrone.The optimal moisture absorption environment of silica-gel desiccant is room temperature (20-32 ℃), high humidity (60-90%), and it can make the relative humidity of environment be reduced to about 40%.The moisture pick-up properties of silica-gel desiccant and the relation of envionmental humidity are bigger, hydroscopicity increases with the increase of ambient humidity, moisture pick-up properties is smaller under the low wet environment, general relative humidity is non-hygroscopic substantially below 10%RH, but under high humidity environment, the hygroscopicity of silica-gel desiccant is relatively good, and hydroscopicity can reach more than 30%.
Molecular sieve desiccant: it is the artificial desiccant product that synthesizes and hydrone is had strong adsorptivity.The pore size of molecular sieve can be controlled by the difference of processing technology, and except the absorption aqueous vapor, it can also adsorb other gas, and still can well hold hydrone under the high temperature more than 230 ℃.The moisture pick-up properties of big molecular sieve desiccant and the relation of envionmental humidity are little, particularly under low wet environment, as also keeping moisture pick-up properties preferably below 10%RH, and moisture pick-up properties is very little with the variation of ambient humidity, but total saturated hydroscopicity is not high, below 18%.
A lot of food and medicine etc. are very harsh to the requirement of humidity in the packaging material, are that hebephrenictype bifidobacteria viable bacteria (DM8504, the production bacterial classification that intestines are happy is available from Dalian Medical Univ) auxiliary material is mainly lactose as the happy active ingredient of Pharmaceutical sausage.This product characteristics has determined the requirement to packaging material: hebephrenictype Bifidobacterium (DM8504) is a gram-positive anaerobic bacterium, be subject to extraneous temperature, the oxygen influence, the freeze drying bacterium powder of hebephrenictype Bifidobacterium is during as medicine and food, be subjected to the temperature in the external environment condition extremely easily, oxygen, influence such as pressure and moisture, particularly airborne oxygen and moisture are easy to cause the oxidation of product, chemical reactions such as hydrolysis, impel bacterium protein rotten, cause viable count sharply to descend, and the existence of oxygen and moisture also can encourage the breeding of other microorganism, so require secluding air and moisture, preferably can build an airtight dry environment that is hedged off from the outer world; In addition, because the auxiliary material lactose moisture absorption very easily, moisture can make the lactose moisture absorption and stickness, the group of formation or piece, and then have influence on the survival environment of active ingredient hebephrenictype Bifidobacterium so damp-prrof packing of this product needed.At present, used drier is received the product of (Kunshan) company for Germany's plug in the happy packing of intestines, and this valuable product makes the happy production cost of intestines also significantly improve, thereby increased patient's financial burden.Up to now, domestic yet there are no about being used for the report of the drier of active bacteria formulation.
Based on the weak point and the market demand of above-mentioned two kinds of drier, pressing for a kind of ambient humidity that is subjected to influences little, as to be applicable to medicine drier.
Summary of the invention
The purpose of this invention is to provide a kind of ambient humidity that is subjected to and influence little, as to can be applicable to active bacteria formulation drier.
For achieving the above object, the present invention takes following design: a kind of drier, its prescription are that molecular sieve and the silica gel of 1-6: 1-8 is formed by ratio of weight and number.
The prescription of described drier is preferably: molecular sieve 2-6 part, silica gel 4-8 part; Especially be preferably 6 parts in molecular sieve, 4 parts in silica gel.
The selection of described molecular sieve is widely, and as the commercially available various apertures and the zeolite product of shape, being preferably the aperture is the big molecular sieve of 1-6A; Especially being preferably the aperture is 3A, and diameter is the big molecular sieve of 0.5-1.25mm.
The selection of described silica gel also is widely, as the commercially available various apertures and the silica gel product of shape, is preferably the silica gel that diameter is 0.5-3.5mm, especially is preferably the silica gel that diameter is 0.5-2.5mm, is preferably the silica gel that diameter is 0.5-1.5mm especially.
In addition, for microbial inoculum product (as intestines happy etc.), the aperture that described molecular sieve is preferably the production of Nanjing unification chemical industry Co., Ltd is 3A, and diameter is the big molecular sieve of 0.5-1.25mm, and the diameter that silica gel is preferably the production of Shenzhen Chun Wang Industrial Co., Ltd. is the silica gel of 0.5-1.5mm.
Second purpose of the present invention provides a kind of preparation method of above-mentioned drier.
The preparation method of drier provided by the present invention is that molecular sieve is mixed for 1-6: 1-8 by ratio of weight and the number of copies with silica gel, obtains drier.
In above-mentioned preparation method, the ratio of weight and number of described molecular sieve and silica gel is preferably 2-6: 4-8; Especially be preferably 6 parts in molecular sieve, 4 parts in silica gel.
Described molecular sieve is preferably the big molecular sieve that the aperture is 1-6A; Especially being preferably the aperture is 3A, and diameter is the big molecular sieve of 0.5-1.25mm.
Described silica gel is preferably the silica gel that diameter is 0.5-3.5mm, especially is preferably the silica gel that diameter is 0.5-2.5mm, is preferably the silica gel that diameter is 0.5-1.5mm especially.
In addition, for microbial inoculum product (as intestines happy etc.), the aperture that described molecular sieve is preferably the production of Nanjing unification chemical industry Co., Ltd is 3A, and diameter is the big molecular sieve of 0.5-1.25mm, and the diameter that silica gel is preferably the production of Shenzhen Chun Wang Industrial Co., Ltd. is the silica gel of 0.5-1.5mm.
The present invention provides a kind of drier and preparation method thereof by meticulous screening.Drier provided by the present invention obtains silica-gel desiccant by the constant weight umber with molecular sieve desiccant than mixing, therefore remedied the weak point of two kinds of drier, have good hygroscopicity, not influenced by ambient humidity, applied widelyly (can be used for different products such as live bacteria agent class preparation, medicine, food, especially active bacteria formulation is had drying effect preferably, but the time that the significant prolongation active bacteria formulation is preserved.) advantage.In addition, the preparation method is simple for this drier, is easy to carry out industrial applications.The present invention has higher actual application value, and market prospects are wide.
Below in conjunction with specific embodiment the present invention is described in further details.
The specific embodiment
Method therefor is conventional method if no special instructions among the following embodiment.
The preparation of embodiment 1, drier and effect detection thereof
One, the preparation of live bacteria agent class preparation drier
The model that to unify chemical industry Co., Ltd available from Nanjing is that (aperture is 3A for 0401267 molecular sieve, diameter is 0.5-1.25mm) be that 0466906 silica gel (diameter is 1.5mm) is to mix at 3: 2 by ratio of weight and the number of copies with model available from company of Nanjing unification chemical industry Co., Ltd, obtain drier.
Two, live bacteria agent class preparation drying effect detects
The intestines pleasure of producing with beautiful pearl pharmaceutical factory is an example, drier in the detection step 1 is to the drying effect of active microbial inoculum, concrete grammar is: with three batches (20030404,20030405,20030406) the happy microbial inoculum of the intestines of Sheng Chaning is respectively with the plastic bottle packing (2.5g drier/20 capsules) of drier of the present invention being housed and not with the blister In Aluminium Foil Packing of drier of the present invention, 25 ℃ of following preservations, and 0,3,6,9,12,18 months, detect the viable count in the packing, testing result is shown in table 1-table 3, containing under the terms of packing of drier of the present invention, the microbial inoculum preservation is still qualified (viable count＞10 after 18 months
6Cfu/g), and not under the ordinary packing condition with drier, preservation after 6 months microbial inoculum with regard to defective (viable count＜10
6Cfu/g), show that drier of the present invention has drying effect preferably to the preservation of active bacteria formulation, can make the microbial inoculum holding time obtain bigger prolongation.
The viable count testing result that table 1 is 20030404 batches
| The preservation time (moon) | Lot number | The several hundred million cfu/g of band desiccant package viable bacteria | Blister In Aluminium Foil Packing viable bacteria data hundred million cfu/g |
| 0 | 20030404 | 28 | 28 |
| 3 | 20030404 | 5.8 | 0.06 |
| 6 | 20030404 | 0.92 | ＜0.01 |
| 9 | 20030404 | 0.21 | - |
| 12 | 20030404 | 0.10 | - |
| 18 | 20030404 | 0.04 | - |
The viable count testing result that table 2 is 20030405 batches
| The preservation time (moon) | Lot number | The several hundred million cfu/g of band desiccant package viable bacteria | Blister In Aluminium Foil Packing viable bacteria data hundred million cfu/g |
| 0 | 20030405 | 26 | 28 |
| 3 | 20030405 | 5.7 | 0.05 |
| 6 | 20030405 | 0.90 | ＜0.01 |
| 9 | 20030405 | 0.20 | - |
| 12 | 20030405 | 0.09 | - |
| 18 | 20030405 | 0.03 | - |
The viable count testing result that table 3 is 20030406 batches
| The preservation time (moon) | Lot number | The several hundred million cfu/g of band desiccant package viable bacteria | Blister In Aluminium Foil Packing viable bacteria data hundred million cfu/g |
| 0 | 20030406 | 36 | 28 |
| 3 | 20030406 | 6.9 | 0.08 |
| 6 | 20030406 | 1.36 | ＜0.01 |
| 9 | 20030406 | 0.25 | - |
| 12 | 20030406 | 0.14 | - |
| 18 | 20030406 | 0.06 | - |
The preparation of embodiment 2, drier and effect detection thereof
One, the preparation of drier
To be 051470 molecular sieve (aperture is 1A) available from the model of company of the Chun Wang of Shenzhen Industrial Co., Ltd. with model be that 056870 silica gel (diameter is 0.5mm) is to mix at 5: 8 by ratio of weight and the number of copies, obtain drier available from company of the Chun Wang of Shenzhen Industrial Co., Ltd..
Two, drying effect detects
Detect the drying effect of the drier of step 1 preparation in order to embodiment 1 identical method to the happy microbial inoculum of intestines of same batch (20030404) production, testing result is as shown in table 4, under room temperature condition (25 ℃) condition, contain under the terms of packing of drier of the present invention, the microbial inoculum preservation is still qualified after 18 months, and not under the ordinary packing condition with drier, preservation after 6 months the microbial inoculum viable count just defective, show that drier of the present invention has drying effect preferably to active bacteria formulation, can make microbial inoculum prolong the holding time.
Table 4 viable count testing result
| The preservation time (moon) | Lot number | The several hundred million cfu/g of band desiccant package viable bacteria | Blister In Aluminium Foil Packing viable bacteria data hundred million cfu/g |
| 0 | 20030404 | 28 | 28 |
| 3 | 20030404 | 10.8 | 0.06 |
| 6 | 20030404 | 5.92 | ＜0.01 |
| 9 | 20030404 | 2.21 | - |
| 12 | 20030404 | 1.10 | - |
| 18 | 20030404 | 0.84 | - |
The preparation of embodiment 3, drier and hygroscopicity thereof detect
One, the preparation of drier
To be 058740 molecular sieve (aperture is 6A) available from the model of company of the bright drier in Hangzhou sea Co., Ltd with model be that 059412 silica gel (diameter is 3.5mm) is to mix at 1: 1 by ratio of weight and the number of copies, obtain drier available from company of the extra large bright drier in Hangzhou Co., Ltd.
Two, hygroscopicity detects
Now detect the hygroscopicity of the drier of step 1 preparation, concrete grammar is: the model of getting the production of Suzhou Shan Dao environmental test equipment Co., Ltd is the growth cabinet of RTOP, initial humidity in the casing is made as 100%RH, close all envirment factor conditioning equipments then, the drier (50g) of step 1 preparation is housed in casing respectively and does not adorn under the situation of drier, the humidity that detects different time in the casing changes, testing result is as shown in table 5, be equipped with under the condition of drier of the present invention, relative humidity in the climate box significantly reduces, and not remarkable with the variation of the humidity in the casing of drier, show that drier of the present invention has hygroscopicity preferably.
Relative humidity testing result in table 5 casing
| Time (hour) | Band drier (%RH) | Be not with drier (%RH) |
| 0 | 100 | 100 |
| 1 | 98 | 100 |
| 2 | 94 | 100 |
| 4 | 90 | 99.8 |
| 6 | 85 | 99.5 |
| 10 | 75 | 99 |
Claims (10)
1, a kind of drier, its prescription are that molecular sieve and the silica gel of 1-6: 1-8 is formed by ratio of weight and number.
2, drier according to claim 1 is characterized in that: described prescription is molecular sieve 2-5 part, silica gel 4-8 part.
3, drier according to claim 1 is characterized in that: the aperture of described molecular sieve is 1-6A.
4, drier according to claim 1 is characterized in that: the diameter of described silica gel is 0.5-3.5mm.
5, according to each described drier of claim 1-4, it is characterized in that: described molecular sieve is that the aperture of the production of Nanjing unification chemical industry Co., Ltd is 3A, diameter is the big molecular sieve of 0.5-1.25mm, and silica gel is that the diameter of the production of Shenzhen Chun Wang Industrial Co., Ltd. is the silica gel of 0.5-1.5mm.
6, a kind of method for preparing each described drier of claim 1-4 is that molecular sieve is mixed for 1-6: 1-8 by ratio of weight and the number of copies with silica gel, obtains drier.
7, method according to claim 6 is characterized in that: the ratio of weight and number of described molecular sieve and silica gel is 2-5: 4-8.
8, according to claim 6 or 7 described methods, it is characterized in that: the aperture of described molecular sieve is 1-6A; Silica gel the aperture be 0.5-3.5mm.
9, according to claim 6 or 7 described methods, it is characterized in that: described molecular sieve is that the aperture of the production of Nanjing unification chemical industry Co., Ltd is 3A, diameter is the big molecular sieve of 0.5-1.25mm, and silica gel is that the diameter of the production of Shenzhen Chun Wang Industrial Co., Ltd. is the silica gel of 0.5-1.5mm.
10, each described drier of claim 1-4 is as the application in the active bacteria formulation drier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101687401A CN100490941C (en) | 2006-12-19 | 2006-12-19 | Use of desiccant in active bacteria drying |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101687401A CN100490941C (en) | 2006-12-19 | 2006-12-19 | Use of desiccant in active bacteria drying |
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| Publication Number | Publication Date |
|---|---|
| CN1994527A true CN1994527A (en) | 2007-07-11 |
| CN100490941C CN100490941C (en) | 2009-05-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101687401A Active CN100490941C (en) | 2006-12-19 | 2006-12-19 | Use of desiccant in active bacteria drying |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582712A (en) * | 2014-11-12 | 2016-05-18 | 浙江三花制冷集团有限公司 | Filter core, and drying filter having same |
| CN108704625A (en) * | 2018-05-31 | 2018-10-26 | 佛山市高明区爪和新材料科技有限公司 | A kind of food desiccant |
| CN110118712A (en) * | 2019-05-16 | 2019-08-13 | 南通联亚药业有限公司 | It is a kind of for measuring the capsule and detection method of aluminum-plastic packaged moisture content Penetration ration |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017521059A (en) | 2014-06-17 | 2017-08-03 | ザイクローブ セラピューティクス, インク.Xycrobe Therapeutics, Inc. | Mechanically aligned optical element and method of manufacturing the same |
| AU2021297215A1 (en) * | 2020-06-23 | 2023-02-09 | Crown Laboratories, Inc. | Probiotic skin formulations |
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2006
- 2006-12-19 CN CNB2006101687401A patent/CN100490941C/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582712A (en) * | 2014-11-12 | 2016-05-18 | 浙江三花制冷集团有限公司 | Filter core, and drying filter having same |
| CN108704625A (en) * | 2018-05-31 | 2018-10-26 | 佛山市高明区爪和新材料科技有限公司 | A kind of food desiccant |
| CN108704625B (en) * | 2018-05-31 | 2020-11-17 | 江苏欧凯包装科技有限公司 | Food drying agent |
| CN110118712A (en) * | 2019-05-16 | 2019-08-13 | 南通联亚药业有限公司 | It is a kind of for measuring the capsule and detection method of aluminum-plastic packaged moisture content Penetration ration |
| CN110118712B (en) * | 2019-05-16 | 2022-03-08 | 南通联亚药业有限公司 | Capsule for determining moisture permeability of aluminum-plastic package and detection method |
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| Publication number | Publication date |
|---|---|
| CN100490941C (en) | 2009-05-27 |
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