CN1994229A - Rotary platform type animals in-vivo multi-mode imaging detection system - Google Patents
Rotary platform type animals in-vivo multi-mode imaging detection system Download PDFInfo
- Publication number
- CN1994229A CN1994229A CN 200610144284 CN200610144284A CN1994229A CN 1994229 A CN1994229 A CN 1994229A CN 200610144284 CN200610144284 CN 200610144284 CN 200610144284 A CN200610144284 A CN 200610144284A CN 1994229 A CN1994229 A CN 1994229A
- Authority
- CN
- China
- Prior art keywords
- imaging
- toy
- detector
- light source
- beam splitter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The invention relates to a biological multimode picture detecting technique, wherein it comprises one PET shooting system with symmetry electrodes, one infrared transparent (reflective) shooting system, one visual light (or fluorescent) transparent (or reflective) shooting system, one ultraviolet (or X-ray) transparent (or reflective) shooting system, one rotation carrier of animal, multi-axle motion controller, multi-channel processor and computer. The carrier comprises one object platform, one frame, one constant-temperature controller, one rotator, and one XYZ three-dimension mover. The invention has multimode composition and 360degree scanning picture, with low cost.
Description
Technical field
The present invention relates to toy imaging in vivo detection technique and scientific instrument apparatus structure, a kind of structure dexterity particularly is provided, with low cost, and also detection sensitivity and resolution are all than higher small animal molecule image detection system and platform structure.
Background technology
It is key link in the systems biology research that toy detects at the body molecular image, also be to explore to Clinical detection by scientific researches such as detection of gene protein molecular level and cellular level detections to use the intermediate axle link beam that transforms, on Nature, Science, just have nearly hundred pieces of related articles to report the achievement in research of this respect in recent years.The research work of carrying out this respect be unable to do without two quasi-instruments, and a kind of is the PET detecting instrument, and the price of external product is more than 3,000,000 → 5,000,000 yuan; Another kind be the toy of Xenogen company at body visible fluorescence detecting instrument, price is about 2,000,000 → 3,000,000 yuan.In addition, adopt the two-photon laser cofocal scanner usually based on the molecule video detection system of cellular level, price is about 300,000 dollars.These system price costlinesses not only, and these systems can only be given in the information that single index that health check-up surveys changes at every turn at present.The resolution of PET detection at present is about 1.6mm, at the penetration depth＜2-3cm of body fluoroscopic examination.
Only there is minority unit can buy PET or toy at home, and is confined to carry out some applied research work, also do not see the product report of homemade toy aspect the health check-up examining system at present at body visible fluorescence detecting instrument.And carried out separately independently basic research in early stage at the PET detecting instrument with in existing how tame unit aspect the body infrared detection technology, develop single at first at home and four row PET people volume imaging equipment researchs as the high the subject of knowledge and the object of knowledge of academy of science, the animal PET resolution of their development is less than 2mm; Tsing-Hua University has proposed a kind of new method at diffuse optical fault imaging theoretical side, successfully solved the border issue that light transports in biological tissue, foretell boundary condition first to the anisotropic dependency of microcosmic scattering, and successfully set up the diffuse optical imaging system and the computed tomography (SPECT) system blank of tissue.
As the development of toy at health check-up survey technology and scientific instrument, comprehensive optical detection and PET detection technique, have complementary advantages, the performance infrared light is to the harmless effect of live body and good deep layer imaging capability, auxiliary with the theoretical inaccuracy problem that solves geometric optics straightline propagation of optical diffuser, will be the important development direction that toy detects at body molecule video.
In detection technique research of body molecular image and scientific instrument development process, develop the key issue that its hardware system relates to three aspects at toy.First system schema and stage apparatus structure, novel system structure conceptual design and stage apparatus structure can simplied system structures, reduced volume, lowering apparatus cost, raising overall performance index.It two is detectors, and it is the core component that toy detects at the body molecular image, and at present external high sensitivity cryogenic refrigeration ccd detector is several ten thousand to tens0000 dollars not to be waited, and has only 3 tame offshore companies to have sophisticated product to release; The key issue of the 3rd aspect is optical system structure and camera lens, the high-quality optical lens of large-numerical aperture long reach is several thousand to more than 10,000 dollars not to be waited, cooperate concrete optical imaging system to customize if desired, then complete optical system and camera lens need several ten thousand dollars, and are monopolized by Zeiss, Nikon and Leica.This shows and to develop toy that development high-performance, scientific instrument cheaply just must solve the key issue of above three aspects earlier in body molecular image detection technique.
Summary of the invention
The purpose of this invention is to provide a kind of multimode and mix, the structure dexterity, with low cost, and also detection sensitivity and resolution are all than higher small animal molecule image detection system and stage apparatus structure.
The invention is characterized in, comprise a bipolar symmetric radio nuclide imaging subsystem [A], and/or infrared transmission or catoptric imaging subsystem [B], and/or visible transmission or catoptric imaging subsystem [C], and/or ultraviolet light or X ray transmission or catoptric imaging subsystem [D], place the rotation article carrying platform of toy, and multi-axis motion controller, the multichannel processor, and computer that connects multi-axis motion controller and multichannel processor, with the toy in the rotation article carrying platform of placing toy is the center, described [A], [B], [C], [D] corresponding imaging subsystems be distributed in this rotation article carrying platform around, and optical axis is in the same plane, intersect in the toy position, perhaps intersect multiple spot according to the deviation of setting;
Wherein said [A], [B], [C], [D] four imaging subsystems decompose according to different compound modes or are combined into single mode, bimodulus, three moulds or the four moulds complex imaging system of totally four class application models;
(1), single mode resolution model: constitute the imaging in vivo subsystem of totally four kinds of simple toys by in described [A], [B], [C], [D] four imaging subsystems any;
(2), bimodulus decomposing scheme, constitute [A] [B], [A] [C], [A] [D], [B] [C], [B] [D], [C] [D] totally six kinds of simple toy imaging in vivo subsystems by described [A], [B], [C], [D] four imaging subsystems, in described six kinds of frame modes, spend the arranged evenly symmetrically of equal angles spacings in the space by 90 between two ingredients of every kind of frame mode, or other angular interval is non-homogeneous symmetric arranged evenly, and every kind of frame mode all can carry out 180 degree rotations to change the position;
(3), three mould decomposing schemes, by described [A], [B], [C], [D] four imaging subsystems by being arranged to form the 24 kinds of blended toy imaging in vivo of three moulds subsystems that order is different, in this three moulds mixed structure mode, each ingredient of each frame mode is spent the arranged evenly symmetrically of equal angles spacings in the space by 60, or other angular interval is non-homogeneous symmetric arranged evenly, and described each frame mode all can carry out 180 degree rotations to change the position;
(4), four mould decomposing schemes, by described [A], [B], [C], [D] four imaging subsystems by being arranged to form the 24 kinds of blended toy imaging in vivo of four moulds subsystems that order is different, in this four moulds mixed structure mode, each ingredient of each frame mode is spent the arranged evenly symmetrically of equal angles spacings in the space by 45, or press the non-homogeneous symmetric arranged evenly of other angular interval settings, each frame mode all can carry out 180 degree rotations to change the position;
Under the effect of described rotation article carrying platform, each frame mode in the above-mentioned various patterns all can be spent the imagings of panorama scope constant temperature 360, or in angular range constant temperature imaging arbitrarily.
The present invention has the following advantages owing to take above design:
1, is provided with the blended toy imaging in vivo of a kind of multimode detection system apparatus structure among the present invention; can carry out compound detection from nucleic PET imaging, infrared light diffuse scattering imaging, visible light and a plurality of patterns such as fluorescence imaging, ultraviolet light and x-ray imaging simultaneously; give full play to their advantage separately; obtain complete, a comprehensive toy at body molecular image image, it is high or penetration depth is limited or locate technical barriers such as inaccurate to solve resolution that present monotype occurs in detecting.
2, be provided with a kind of toy imaging in vivo detection system apparatus structure that rotates article carrying platform among the present invention, compare with common fixedly article carrying platform imaging detection scheme, can realize the scanning imagery in the 360 degree panorama scopes, can be from different perspectives or a plurality of angle obtain toy in the imaging of body molecular image.Can obtain the accurate position of photogenic tissue in the petty action object (or organ, or cell, or gene protein molecule) by a plurality of angular cross location, solve monotype or folk prescription and can't carry out the accurate location technology difficult problem of diffusion object in the petty action object to imaging.Can only obtain the information of a direction as fixing single mode imaging, and the present invention can realize 360 degree scopes, a plurality of directional informations of running accuracy 0.1 degree; And for example monotype or folk prescription adopt straightline propagation approximate to the location of imaging, even thick its deviation of clear glass of 1cm can reach mm magnitude level, a plurality of angular cross locate modes of employing the present invention then can be with Deviation Control in micron level.
3, the invention provides a kind of article carrying platform that rotates and carry out the detection system apparatus structure of toy in body 360 degree panoramic scanning imagings, have simple in structurely, cost is low, resolution height (can reach 10um), characteristics such as realization easily; Simultaneously, imaging optical path is fully separately independent, has also avoided the interference effect problem of multi-mode complex imaging.
Description of drawings
Fig. 1 is a multimode complex imaging system structure sketch map of the present invention;
Fig. 2 is a multimode complex imaging system architecture diagram of the present invention;
Fig. 3 is multimode complex imaging systematic reflection photoimaging embodiment one structural representation of the present invention;
Fig. 4 is multimode complex imaging systematic reflection photoimaging embodiment one structured flowchart of the present invention;
Fig. 5 is multimode complex imaging systematic reflection photoimaging embodiment two structural representations of the present invention;
Fig. 6 is multimode complex imaging systematic reflection photoimaging embodiment two structured flowcharts of the present invention;
Fig. 7 is a rotation platform structural representation of the present invention;
Fig. 8 is a rotation platform structured flowchart of the present invention;
Fig. 9 is the computer software image processing workflow diagram of multimode image reconstruction.
The specific embodiment
For achieving the above object; the invention provides a kind of rotary platform type toy and mix image-forming detecting system in the body multimode; include a bipolar symmetric nucleic (PET) imaging system, an infrared transmission (or reflection) imaging system, a visible light (or fluorescence) transmission (or reflection) imaging system, a ultraviolet light (or X ray) transmission (or reflection) imaging system, a multi-axis motion controller (abbreviation multi-axis controller) and a multi channel signals processor (being called for short the multichannel processor), and the rotation article carrying platform of placing toy.
A described bipolar symmetric nucleic (PET) imaging system includes two crystal layers, two ray detectors (PET detector).
Described infrared transmission (or reflection) imaging system includes an infrared illumination light source (or infrared light fiber array lighting source, or infrared light single fiber lighting source, or non-many optical fibre illuminations of array type infrared light light source), an imaging len (or battery of lens, or array lens), infrared detector (CCD, or photomultiplier tube PMT, or photon counter, or other electrooptical device).In the reflection imaging system of infrared light, also include a beam splitter member (prism, or dichroic mirror, or pleochroism mirror).
Described visible light (or fluorescence) transmission (or reflection) imaging system includes a visible illumination light source (laser, or LED, or other polychromatic light light source, it can be one or more combination visible illumination light source, it also can be the matrix lamp light source that these light sources are formed, or by other beam splitting device, point source or line source or area source etc. that conversions such as optical fiber transmission light energy is thrown light on), an imaging len (or battery of lens, or array lens), a visible light (or fluorescence) detector (CCD, or PMT, or photon counter, or other electrooptical device).In the reflection imaging system of visible light (or fluorescence), also include a beam splitter member (prism, or dichroic mirror, or pleochroism mirror).
Described ultraviolet light (or X ray) transmission (or reflection) imaging system includes a ultraviolet light (or X ray) lighting source (or matrix lamp light source, or compound lighting source of non-array type multichannel), a ultraviolet light (or X ray) imaging len (or battery of lens, or array lens), a ultraviolet light (or X ray) detector (CCD, or PMT, or photon counter, or other electrooptical device).In the reflection imaging system of ultraviolet light, also include a beam splitter member (prism, or dichroic mirror, or pleochroism mirror).
The rotation article carrying platform of described placement toy includes a round (or square, or rib type, or other shape) article carrying platform and platform cover, a thermostatically-controlled equipment, (control can be direct current generator to a rotation device, or motor, or wait upon the clothes motor, or manpower manual actuation control structure), (control can be electronic to an XYZ three-dimensional motion device structure, or manpower is manually controlled), a multi-axis motion controller (abbreviation multi-axis controller).Described XYZ three-dimensional motion device structure comprises guide rail and slide block (can be a single-rail, also can adopt two guide rails), leading screw (can be installed on the limit of supporting plate, or central authorities, or other positions), if full-automatic electric control also has three motors (can be direct current generator, or motor, or wait upon the clothes motor), the mode that also can adopt the electronic control of part (one dimension, or two dimension) to combine with partially manual adjusting.Described multi-axis motion controller is made up of motor drive module and motor control segmentation module, and motor drive module provides multichannel (1 tunnel, or 2 the tunnel, or 3 the tunnel, or 4 the tunnel, or 5 the tunnel) driving power (+12V, or-12V, or ± 12V, or+5V, or-5V, or ± 5V, or+3.5V, or-3.5V, or ± 3.5V, or+24V, or-24V, or ± 24V, or+15V, or-15V, or ± 15V, or other voltages), comprise step motor drive and motor control segmentation module, multiple angles segmentation conversion and control (2 segmentations, 4 segmentations, 8 segmentations can be provided, 16 segmentations, 32 segmentations, 64 segmentations, 128 segmentations, 256 segmentations, 512 segmentations, or other segmentations).
Above-mentioned acquisition of signal digital processing system includes a computer, a multichannel processor (or multiplexed signal sampling card), the outfan of described multiple detector links to each other with this multichannel processor, and by computer interface input computer, generate a width of cloth width of cloth digital image, temporary in computer earlier, carry out position correction, image by computer software, form a complete toy at body multi-modality imaging detection signal image.Described multichannel processor can be the multiplexed signal sampling card, or multi-channel A/D capture card, or multiple signals receive processing unit, multichannel can be any one numeral in 1 road to 128 tunnel, every road can work independently, and also can be work fully simultaneously, or work not exclusively simultaneously.The computer software image processing workflow of multimode image reconstruction as shown in Figure 9.
At first carrying out the imaging of multimode independence (can be the while or synchronous, can be not yet simultaneously or asynchronous), image to the different mode imaging carries out characteristic point identification processing, in the process of seeking characteristic point, adopt traditional computer image treatment fuzzy diagnosis algorithm, the image size of Feature Points Matching correspondence can be selected the matrix symmetrical structure of 2 * 2 or 3 * 3 or 4 * 4 or 5 * 5 or 6 * 6 or 7 * 7 or 8 * 8 or 9 * 9 or 10 * 10 pixels, also can select the structure of square, " ten " font or other shape.Then carry out relative position deviation and calculate, adopt pixel coordinates difference computational methods, calculate the position deviation Xc of same characteristic point (or target object image center) under the different mode
mAnd Yc
m, as modifying factor, wherein m represents different mode, m=1,2,3,4.Then, and application of formula X ' m (i, j)=Xm (i, j)-Xc
mAnd Y ' m (i, j)=Ym (i, j)-Yc
m, wherein Xm (i, j) and Ym (i, the j) pixel coordinates of expression different mode imaging just can obtain the correction position coordinate of different mode image, and the precision of image position correction can reach 1 pixel.At last, the different mode image behind the correction position is carried out the image fusion be superimposed, obtain the image of multimode complex imaging.
As depicted in figs. 1 and 2; be a kind of multimode blended toy imaging in vivo detection system provided by the invention and platform structure; include the rotation article carrying platform of a bipolar symmetric nucleic (PET) imaging system, an infrared transmission (or reflection) imaging system, a visible light (or fluorescence) transmission (or reflection) imaging system, a ultraviolet light (or X ray) transmission (or reflection) imaging system, placement toy, and multi-axis motion controller (abbreviation multi-axis controller), multichannel processor (or multi-channel signal acquiring card) and computer system.With the toy in the rotation article carrying platform of placing toy is the center, a bipolar symmetric nucleic (PET) imaging system, infrared transmission (or reflection) imaging system, a visible light (or fluorescence) transmission (or reflection) imaging system, a ultraviolet light (or X ray) transmission (or reflection) imaging system etc. be distributed in article carrying platform around, and central axis (or optical axis) is in same plane, intersect in the toy position, can intersect same point, also can keep certain deviation to intersect a plurality of points.
Bipolar symmetrical nucleic (PET) imaging system in the present embodiment includes two crystal layers, two ray detectors (PET detector), the distribution of crystal layer and detector with the toy be the center point-blank, structural order is detector 11 → crystal layer 12 → toy 00 → crystal layer 13 → detector 14, or structural order is detector 11 ← crystal layer 12 ← toy 00 ← crystal layer 13 ← detector 14, and detector 11 and 14 signals that receive are by multichannel processor (or multi-channel signal acquiring card) 01 input computer 02.
Infrared transmission in the present embodiment (or reflection) imaging system includes an infrared illumination light source (or infrared light fiber array lighting source, or infrared light single fiber lighting source, or non-many optical fibre illuminations of array type infrared light light source), an imaging len (or battery of lens, or array lens), infrared detector (CCD, or PMT, or photon counter, or other electrooptical device).In the reflection imaging system of infrared light, also include a beam splitter member (prism, or dichroic mirror, or pleochroism mirror).In the infrared transmission imaging system, infrared illumination light source and imaging len and detector are distributed in the both sides of toy, structural order is infrared illumination light source 21 → toy 00 → imaging len 22 → detector 23, and the signal that detector 23 receives is by multichannel processor (or multi-channel signal acquiring card) 01 input computer 02.In the infrared light reflection imaging system, as shown in Figure 3 and Figure 4, infrared illumination light source, beam splitter member, imaging len and detector are distributed in the homonymy of toy, structural order is infrared illumination light source 21 → beam splitter member 24 → toy 00 → beam splitter member 24 → imaging len 22 → detector 23, and the signal that detector 23 receives is by multichannel processor (or multi-channel signal acquiring card) 01 input computer 02.In the reflection imaging system of infrared light, also can adopt another kind of structural order: infrared illumination light source 21 → beam splitter member 24 → imaging len 22 → toy 00 → imaging len 22 → beam splitter member 24 → detector 23, the signal that detector 23 receives is by multichannel processor (or multi-channel signal acquiring card) 01 input computer 02, as shown in Figure 5 and Figure 6.
Visible light in the present embodiment (or fluorescence) transmission (or reflection) imaging system includes a visible illumination light source (laser, or LED, or other polychromatic light light source, it can be one or more combination visible illumination light source, it also can be the matrix lamp light source that these light sources are formed, or by other beam splitting device, point source or line source or area source etc. that conversions such as optical fiber transmission light energy is thrown light on), an imaging len (or battery of lens, or array lens), a visible light (or fluorescence) detector (CCD, or PMT, or photon counter, or other electrooptical device).In the reflection imaging system of visible light (or fluorescence), also include a beam splitter member (prism, or dichroic mirror, or pleochroism mirror).In the visible transmission imaging system, the both sides that are distributed in toy of visible illumination light source, imaging len and detector, structural order is visible illumination light source 31 → toy 00 → imaging len 32 → detector 33, and the signal that detector 33 receives is by multichannel processor (or multi-channel signal acquiring card) 01 input computer 02.In the reflection imaging system of visible light (or fluorescence), as shown in Figure 3 and Figure 4, the homonymy that is distributed in toy of visible illumination light source, imaging len and detector, structural order is visible illumination light source 31 → beam splitter member 34 → toy 00 → beam splitter member 34 → imaging len 32 → detector 33, and the signal that detector 33 receives is by multichannel processor (or multi-channel signal acquiring card) 01 input computer 02.In the reflection imaging system of visible light (or fluorescence), also can adopt another kind of structural order: visible illumination light source 31 → beam splitter member 34 → imaging len 32 → toy 00 → imaging len 32 → beam splitter member 34 → detector 33, the signal that detector 33 receives is by multichannel processor (or multi-channel signal acquiring card) 01 input computer 02, as shown in Figure 5 and Figure 6.
Ultraviolet light in the present embodiment (or X ray) transmission (or reflection) imaging system includes a ultraviolet light (or X ray) lighting source (or matrix lamp light source, or compound lighting source of non-array type multichannel), a ultraviolet light (or X ray) imaging len (or battery of lens, or array lens), a ultraviolet light (or X ray) detector (CCD, or PMT, or photon counter, or other electrooptical device).In the ultraviolet light reflection imaging system, also include a beam splitter member (prism, or dichroic mirror, or pleochroism mirror).In ultraviolet light (or X ray) transmission imaging system, the both sides that are distributed in toy of ultraviolet light (or X ray) lighting source, imaging len and detector, structural order is ultraviolet light (or X ray) lighting source 41 → toy 00 → imaging len 42 → detector 43, and the signal that detector 43 receives is by multichannel processor (or multi-channel signal acquiring card) 01 input computer 02.In the reflection imaging system of ultraviolet light, as shown in Figure 3 and Figure 4, the homonymy that is distributed in toy of ultraviolet illumination light source, imaging len and detector, structural order is ultraviolet illumination light source 41 → beam splitter member 44 → toy 00 → beam splitter member 44 → imaging len 42 → detector 43, and the signal that detector 43 receives is by multichannel processor (or multi-channel signal acquiring card) 01 input computer 02.In the ultraviolet light reflection imaging system, also can adopt another kind of structural order: ultraviolet illumination light source 41 → beam splitter member 44 → imaging len 42 → toy 00 → imaging len 42 → beam splitter member 44 → detector 43, the signal that detector 43 receives is by multichannel processor (or multi-channel signal acquiring card) 01 input computer 02, as shown in Figure 5 and Figure 6.
The rotation article carrying platform of placement toy in the present embodiment includes a round (or square, or rib type, or other shape) article carrying platform and platform cover, a thermostatically-controlled equipment, (control can be direct current generator to a rotation device, or motor, or wait upon the clothes motor, or manpower manual actuation control structure), (control can be electronic to an XYZ three-dimensional motion device structure, or manpower is manually controlled), a multi-axis controller, as shown in Figure 7 and Figure 8.Described XYZ three-dimensional motion device structure comprises guide rail and slide block (can be a single-rail, also can adopt two guide rails), leading screw (can be installed on the limit of supporting plate, or central authorities, or other positions), if full-automatic electric control also has three motors (can be direct current generator, or motor, or wait upon the clothes motor, the mode that also can adopt the electronic control of part (one dimension, or two dimension) to combine with partially manual adjusting.In rotation article carrying platform structure, the platform cover, article carrying platform, thermostatically-controlled equipment, rotation device, XYZ three-dimensional motion device structure (XYZ three-dimensional motion mechanism and X-axis motor, y-axis motor, the Z spindle motor) and multi-axis controller form the stratiform overlaying structure, structural order is platform cover 51 → toy 00 → article carrying platform seat 52 → thermostatically-controlled equipment 53 → rotation device 54 → XYZ three-dimensional motion device 55 → multi-axis controller 56, computer 02 is rotated or the motion of XYZ direction by multi-axis controller 56 control article carrying platforms 52, and receiving feedback signals sends the instruction of stop motion, guarantees that movement position is accurate.
In Fig. 1 and Fig. 2, the structure distribution position of a bipolar symmetric nucleic (PET) imaging system [A], an infrared transmission (or reflection) imaging system [B], a visible light (or fluorescence) transmission (or reflection) imaging system [C] and a ultraviolet light (or X ray) transmission (or reflection) imaging system [D] can be that the uniform distribution of 45 degree equal angles spacings is arranged, the uniform distribution that also can be other angular interval is arranged, and can also be that the non-uniform Distribution of not equal angles spacing is arranged.Simultaneously, putting in order of four kinds of patterns can be combined into 24 kinds of different sequential organizations, that is: 1, [A] [B] [C] [D]; [A] [B] [D] [C]; [A] [C] [B] [D]; [A] [C] [D] [B]; [A] [D] [B] [C]; [A] [D] [C] [B]; [B] [A] [C] [D]; [B] [A] [D] [C]; [B] [C] [A] [D]; [B] [C] [D] [A]; [B] [D] [A] [C]; [B] [D] [C] [A]; [C] [A] [B] [D]; [C] [A] [D] [B]; [C] [B] [A] [D]; [C] [B] [D] [A]; [C] [D] [A] [B]; [C] [D] [B] [A]; [D] [A] [B] [C]; [D] [A] [C] [B]; [D] [B] [A] [C]; [D] [B] [C] [A]; [D] [C] [A] [B]; [D] [C] [B] [A].
2, in the above in 24 kinds of frame modes, each system all can carry out 180 degree rotations and change positional structures.
In the multi-mode system of Fig. 1 and Fig. 2 embodiment, can resolve into the hybrid system of different application patterns such as single mode, bimodulus, three moulds and four moulds.Use [A], [B], [C] and [D] four letters to replace respectively a bipolar symmetric nucleic (PET) imaging system [A], an infrared transmission (or reflection) imaging system [B], a visible light (or fluorescence) transmission (or reflection) imaging system [C], a ultraviolet light (or X ray) transmission (or reflection) imaging system [D] etc., concrete decomposing scheme is as follows:
(1), based on the 360 degree panorama scope imagings of rotation platform Scan Architecture or the single mode decomposing scheme of arbitrarily angled scope imaging, can realize a bipolar symmetric nucleic (PET) imaging system [A] respectively, an or infrared transmission (or reflection) imaging system [B], an or visible light (or fluorescence) transmission (or reflection) imaging system [C], an or ultraviolet light (or X ray) transmission (or reflection) imaging system four kinds of simple toy imaging in vivo detection system constructional devices such as [D].
(2), based on the bimodulus decomposing scheme of 360 degree panorama scope imagings or arbitrarily angled scope imagings of rotation platform Scan Architecture, can realize [A] [B], [A] [C], [A] [D], [B] [C], [B] [D], [C] six kinds of simple toy imaging in vivo detection system constructional devices such as [D] respectively.The structure distribution position of bimodulus hybrid system can be the arranged evenly symmetrically of 90 degree equal angles spacings, also can be the non-homogeneous symmetric arranged evenly of other angular interval.In 6 kinds of frame modes, each system all can carry out 180 degree rotations and change positional structures in the above.
(3); based on 360 degree panorama scope imagings of rotation platform Scan Architecture or three mould decomposing schemes of arbitrarily angled scope imaging, can realize [A] [B] [C] respectively; [A] [C] [B]; [A] [B] [D]; [A] [D] [B]; [A] [C] [D]; [A] [D] [C]; [B] [A] [C]; [B] [C] [A]; [B] [A] [D]; [B] [D] [A]; [B] [C] [D]; [B] [D] [C]; [C] [A] [B]; [C] [B] [A]; [C] [B] [D]; [C] [D] [B]; [C] [A] [D]; [C] [D] [A]; [D] [B] [C]; [D] [C] [B]; [D] [A] [B]; [D] [B] [A]; [D] [A] [C]; [D] [C] the 24 kind of three blended toy imaging in vivo of mould detection system constructional devices such as [A].The structure distribution position of three mould hybrid systems can be the arranged evenly symmetrically of 60 degree equal angles spacings, also can be the non-homogeneous symmetric arranged evenly of other angular interval.In 24 kinds of frame modes, each system all can carry out 180 degree rotations and change positional structures in the above.
(4), 24 kinds of different sequential organizations are arranged, that is: [A] [B] [C] [D] based on four mould decomposing schemes of 360 degree panorama scope imagings or arbitrarily angled scope imagings of rotation platform Scan Architecture; [A] [B] [D] [C]; [A] [C] [B] [D]; [A] [C] [D] [B]; [A] [D] [B] [C]; [A] [D] [C] [B]; [B] [A] [C] [D]; [B] [A] [D] [C]; [B] [C] [A] [D]; [B] [C] [D] [A]; [B] [D] [A] [C]; [B] [D] [C] [A]; [C] [A] [B] [D]; [C] [A] [D] [B]; [C] [B] [A] [D]; [C] [B] [D] [A]; [C] [D] [A] [B]; [C] [D] [B] [A]; [D] [A] [B] [C]; [D] [A] [C] [B]; [D] [B] [A] [C]; [D] [B] [C] [A]; [D] [C] [A] [B]; [D] [C] [B] [A].The structure distribution position of four mould hybrid systems can be the arranged evenly symmetrically of 45 degree equal angles spacings, also can be the non-homogeneous symmetric arranged evenly of other angular interval.In these 24 kinds of frame modes, each system all can carry out 180 degree rotations and change positional structure.
In Fig. 7 and Fig. 8, the rotation article carrying platform of placing toy includes round (or square, or rib type, or other a shape) article carrying platform and a platform cover, a thermostatically-controlled equipment, (control can be direct current generator to a rotation device, or motor, or waits upon the clothes motor, or manpower manual actuation control structure), an XYZ three-dimensional motion device structure (control can be electronic, or manpower is manually controlled), a multi-axis controller.Described XYZ three-dimensional motion device structure comprises guide rail and slide block (can be a single-rail, also can adopt two guide rails), leading screw (can be installed on the limit of supporting plate, or central authorities, or other positions), also can adopt rack-and-pinion or belt wheel tooth bar mode to carry out transmission, (can be direct current generator if full-automatic electric control also has three motors, or motor, or wait upon the clothes motor, the mode that also can adopt the electronic control of part (one dimension, or two dimension) to combine with partially manual adjusting.In rotation article carrying platform structure, platform cover, article carrying platform, thermostatically-controlled equipment, rotation device, XYZ three-dimensional motion device structure and multi-axis controller are formed the stratiform overlaying structure, and structural order is platform cover 51 → toy 00 → article carrying platform 52 → thermostatically-controlled equipment 53 → rotation device 54 → XYZ three-dimensional motion device 55 → multi-axis controller 56.
In the rotation article carrying platform of Fig. 7 and Fig. 8 embodiment, can resolve into rotation single shaft telecontrol equipment, rotation with Z to the bonded biaxial movement device of motion, rotation with XZ to the bonded three-axis moving device of motion, rotation and YZ to bonded three-axis moving device, rotation and XYZ the article carrying platform structure of moving to the different motion control models such as bonded four axes motion device of moving.
In the rotation article carrying platform of this Fig. 7 and Fig. 8 embodiment, the control accuracy that rotatablely moves is 〉=0.1 degree, the scope that rotatablely moves 0 → 360 degree; The precision of XYZ scanning motion platform is 〉=5um XYZ scanning motion all directions movement travel scope 0 → 500mm; Thermostatic control precision 〉=0.5 degree, variable temperatures scope 0 → 50 degree.
The present invention is by top design, and the specific performance index that it can reach is as follows:
＜1 〉, system can realize that toy detects at the complex imaging of the different application patterns such as single mode, bimodulus, three moulds and four moulds of body.
＜2 〉, system can realize that 0.1 degree fine scanning imaging of 360 degree panorama scopes detects.
＜3 〉, the system optics detection resolution less than 10 microns (greater than 100 lines right/mm), tested toy physical dimension 0 → 500mm.
＜4 〉, system's nucleic and X ray detection resolution reach 1mm, tested toy physical dimension 0 → 500mm.
＜5 〉, the scanning motion precision of system XYZ direction is 〉=5um XYZ all directions movement travel scope 0 → 500mm.
＜6 〉, variable temperatures scope 0 → 50 degree is spent in thermostatic control precision 〉=0.5 of system.
Claims (14)
1, a kind of rotary platform type toy is at the body multi-mode imaging detection system, it is characterized in that, comprise a bipolar symmetric radio nuclide imaging subsystem [A], and/or infrared transmission or catoptric imaging subsystem [B], and/or visible transmission or catoptric imaging subsystem [C], and/or ultraviolet light or X ray transmission or catoptric imaging subsystem [D], place the rotation article carrying platform of toy, and multi-axis motion controller, the multichannel processor, and computer that connects multi-axis motion controller and multichannel processor, with the toy in the rotation article carrying platform of placing toy is the center, described [A], [B], [C], [D] corresponding imaging subsystems be distributed in this rotation article carrying platform around, and optical axis is in the same plane, intersect in the toy position, perhaps intersect multiple spot according to the deviation of setting;
Wherein said [A], [B], [C], [D] four imaging subsystems decompose according to different compound modes or are combined into single mode, bimodulus, three moulds or the four moulds complex imaging system of totally four class application models;
(1), single mode resolution model: constitute the imaging in vivo subsystem of totally four kinds of simple toys by in described [A], [B], [C], [D] four imaging subsystems any;
(2), bimodulus decomposing scheme, constitute [A] [B], [A] [C], [A] [D], [B] [C], [B] [D], [C] [D] totally six kinds of simple toy imaging in vivo subsystems by described [A], [B], [C], [D] four imaging subsystems, in described six kinds of frame modes, spend the arranged evenly symmetrically of equal angles spacings in the space by 90 between two ingredients of every kind of frame mode, or other angular interval is non-homogeneous symmetric arranged evenly, and every kind of frame mode all can carry out 180 degree rotations to change the position;
(3), three mould decomposing schemes, by described [A], [B], [C], [D] four imaging subsystems by being arranged to form the 24 kinds of blended toy imaging in vivo of three moulds subsystems that order is different, in this three moulds mixed structure mode, each ingredient of each frame mode is spent the arranged evenly symmetrically of equal angles spacings in the space by 60, or other angular interval is non-homogeneous symmetric arranged evenly, and described each frame mode all can carry out 180 degree rotations to change the position;
(4), four mould decomposing schemes, by described [A], [B], [C], [D] four imaging subsystems by being arranged to form the 24 kinds of blended toy imaging in vivo of four moulds subsystems that order is different, in this four moulds mixed structure mode, each ingredient of each frame mode is spent the arranged evenly symmetrically of equal angles spacings in the space by 45, or press the non-homogeneous symmetric arranged evenly of other angular interval settings, each frame mode all can carry out 180 degree rotations to change the position;
Under the effect of described rotation article carrying platform, each frame mode in the above-mentioned various patterns all can be spent the imagings of panorama scope constant temperature 360, or in angular range constant temperature imaging arbitrarily.
2; a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that; described bipolar symmetrical nucleic imaging subsystems; comprise two crystal layers (12); (13) and two ray detectors (11); (14); the distribution of crystal layer and this ray detector with the toy be the center point-blank; structural order is detector (11) → crystal layer (12) → toy (00) → crystal layer (13) → detector (14); or structural order is detector (11) ← crystal layer (12) ← toy (00) ← crystal layer (13) ← detector (14), and the signal that detector (11) and (14) receive is by multichannel processor (01) input computer (02).
3; a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that; described infrared transmission (or reflection) imaging system; include an infrared illumination light source (21); an imaging len (22); an infrared detector (23); this infrared illumination light source (21) is distributed in a side of toy (00); imaging lens (22) and infrared detector (23) then are distributed in the opposite side of toy (00); the structural order of light path is followed successively by infrared illumination light source (21) → toy (00) → imaging len (22) → infrared detector (23), and the signal that this detector (23) receives is by multichannel processor (01) input computer (02).
4; a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that; described infrared light reflection imaging system; include an infrared illumination light source (21); an imaging len (22); an infrared detector (23); a beam splitter member (24); all be distributed in the homonymy of toy (00); it is infrared illumination light source (21) → beam splitter member (24) → toy (00) → beam splitter member (24) → imaging len (22) → detector (23) that the structural order of light path is followed successively by structural order; the another kind of structural order of light path is followed successively by infrared illumination light source (21) → beam splitter member (24) → imaging len (22) → toy (00) → imaging len (22) → beam splitter member (24) → detector (23), and the signal that detector (23) receives is by multichannel processor (01) input computer (02).
5, a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that; described infrared light reflection imaging system; the structural order of light path is followed successively by infrared illumination light source (21) → beam splitter member (24) → imaging len (22) → toy (00) → imaging len (22) → beam splitter member (24) → detector (23), and the signal that detector (23) receives is by multichannel processor (01) input computer (02).
6; a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that; described visible transmission imaging system includes a visible illumination light source (31); an imaging len (32); a visible-light detector (33); visible illumination light source (31) is distributed in a side of toy (00); and imaging lens (32) and visible-light detector (33) are distributed in the opposite side of toy (00); light channel structure is visible illumination light source (31) → toy (00) → imaging len (32) → visible-light detector (33) in proper order, and the signal that visible-light detector (33) receives is by multichannel processor (01) input computer (02).
7; a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that; described visible light reflection imaging system includes a visible illumination light source (31); an imaging len (32); a visible-light detector (33); a beam splitter member (34); all be distributed in the homonymy of toy (00); the structural order of light path is followed successively by visible illumination light source (31) → beam splitter member (34) → toy (00) → beam splitter member (34) → imaging len (32) → visible-light detector (33), and the signal that this detector (33) receives is by multichannel processor (01) input computer (02).
8; a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that; described visible light reflection imaging system includes a visible illumination light source (31); an imaging len (32); a visible-light detector (33); a beam splitter member (34); all be distributed in the homonymy of toy (00); the structural order of light path is followed successively by visible illumination light source (31) → beam splitter member (34) → imaging len (32) → toy (00) → imaging len (32) → beam splitter member (34) → visible-light detector (33), and the signal that this detector (33) receives is by multichannel processor (01) input computer (02).
9; a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that; described ultraviolet light transmission imaging system includes a ultraviolet illumination light source (41); ultraviolet light imaging lens (42); a ultraviolet light detector (43); ultraviolet illumination light source (41) is distributed in a side of toy (00); and ultraviolet light imaging lens (42) and ultraviolet light detector (43) are distributed in the opposite side of toy (00); light channel structure is ultraviolet illumination light source (41) → toy (00) → ultraviolet light imaging lens (42) → ultraviolet light detector (43) in proper order, and the signal that this detector (43) receives is by multichannel processor (01) input computer (02).
10; a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that; described ultraviolet light reflection imaging system includes a ultraviolet illumination light source (41); ultraviolet light imaging lens (42); a ultraviolet light detector (43); a beam splitter member (44); all be distributed in the homonymy of toy (00); the structural order of light path is followed successively by ultraviolet illumination light source (41) → beam splitter member (44) → toy (00) → beam splitter member (44) → imaging len (42) → detector (43), and the signal that this detector (43) receives is by multichannel processor (or multi-channel signal acquiring card) (01) input computer (02).
11; a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that; described ultraviolet light reflection imaging system includes a ultraviolet illumination light source (41); ultraviolet light imaging lens (42); a ultraviolet light detector (43); a beam splitter member (44); all be distributed in the homonymy of toy (00); the structural order of light path is followed successively by ultraviolet illumination light source (41) → beam splitter member (44) → imaging len (42) → toy (00) → imaging len (42) → beam splitter member (44) → detector (43), and the signal that this detector (43) receives is by multichannel processor (or multi-channel signal acquiring card) (01) input computer (02).
12, a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system, it is characterized in that described rotation article carrying platform comprises:
A platform base (52) and a platform cover (51) that is placed on this platform base (52) are loaded with toy (00) in this platform cover (51);
A thermostatically-controlled equipment (53) is positioned under the platform base (52) and contacts, and keeps having in the platform cover (51) temperature range of a suitable toy (00) existence;
A rotation device (54) is positioned under the thermostatically-controlled equipment (53), rotates by driven by motor platform cover (51), platform base (52), thermostatically-controlled equipment (53);
An XYZ three-dimensional motion device (55) of forming by X motor, Y motor, Z motor and corresponding actuating device, drive platform cover (51), platform base (52), thermostatically-controlled equipment (53), rotation device (54) work three-dimensional, described each spindle motor is by a multi-axis motion controller (56) control, and this multi-axis motion controller (56) is subjected to computer (02) control.
13, a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that described multi-axis motion controller (56) is by motor drive power supply and comprise that the motor segmentation is arranged on interior multiple application function control, motor angle control device and forms.
14, a kind of multimode according to claim 1 is mixed toy imaging in vivo detection system; it is characterized in that described computer (02) generates multi-mode image according to following steps: it is synthetic that multimode independence imaging → searching characteristic point → relative position deviation calculating → position correction → image merges stack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101442847A CN100450440C (en) | 2006-12-01 | 2006-12-01 | Rotary platform type animals in-vivo multi-mode imaging detection system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101442847A CN100450440C (en) | 2006-12-01 | 2006-12-01 | Rotary platform type animals in-vivo multi-mode imaging detection system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1994229A true CN1994229A (en) | 2007-07-11 |
| CN100450440C CN100450440C (en) | 2009-01-14 |
Family
ID=38249498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101442847A Expired - Fee Related CN100450440C (en) | 2006-12-01 | 2006-12-01 | Rotary platform type animals in-vivo multi-mode imaging detection system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100450440C (en) |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653355B (en) * | 2009-09-11 | 2012-01-11 | 华中科技大学 | Living small animal imaging system and imaging method |
| CN102319058A (en) * | 2011-09-09 | 2012-01-18 | 清华大学 | Three-mode small animal imaging system integrating fluorescence, nuclei and X rays |
| CN102753962A (en) * | 2010-11-30 | 2012-10-24 | 中国科学院自动化研究所 | System and method for multimode three dimensional optical tomography based on specificity |
| CN101584576B (en) * | 2009-07-06 | 2013-01-02 | 上海展弈信息科技有限公司 | Automatic detecting system for spontaneous pain behaviours of animals |
| CN102871679A (en) * | 2012-09-20 | 2013-01-16 | 清华大学 | In-vivo multi-mode imaging detecting system with resolution being at least 50 mu m |
| CN103188989A (en) * | 2012-04-28 | 2013-07-03 | 清华大学 | Method for reconstructing dynamic fluorescence molecular tomography |
| CN104873212A (en) * | 2015-04-05 | 2015-09-02 | 清华大学 | Dual-mode coaxial in-vivo imaging method and dual-mode coaxial in-vivo imaging system |
| CN104888356A (en) * | 2015-06-30 | 2015-09-09 | 瑞地玛医学科技有限公司 | Image guide and breathing exercise analysis method |
| CN103610471B (en) * | 2013-12-16 | 2015-10-28 | 中国科学院自动化研究所 | A kind of Optical multi-mode state imaging system and method |
| CN106199673A (en) * | 2016-09-07 | 2016-12-07 | 武汉京邦科技有限公司 | A kind of bimodulus positron imaging machine based on event count |
| CN107242860A (en) * | 2017-07-25 | 2017-10-13 | 京东方科技集团股份有限公司 | Fluorescent molecular tomography system and method |
| CN108387519A (en) * | 2018-05-03 | 2018-08-10 | 上海市质子重离子临床技术研发中心 | Microscopic system is just set in up-conversion luminescence near-infrared and the multi-functional wide field of colour imaging |
| CN109998480A (en) * | 2019-02-01 | 2019-07-12 | 中国科学院苏州生物医学工程技术研究所 | Internal drug Vivo Studies on Screening system |
| CN113109307A (en) * | 2021-04-01 | 2021-07-13 | 南京超维景生物科技有限公司 | Displacement control method and device, electronic equipment and multi-photon fluorescence imaging equipment |
| CN113827194A (en) * | 2021-11-01 | 2021-12-24 | 锘海生物科学仪器(上海)有限公司 | Near-infrared two-zone living body fluorescence imaging system |
| CN116942078A (en) * | 2022-04-19 | 2023-10-27 | 上海天能生命科学有限公司 | Living body imaging system |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101915616B (en) * | 2010-07-22 | 2012-01-11 | 南昌航空大学 | Spiral emission spectral chromatography device |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5816256A (en) * | 1997-04-17 | 1998-10-06 | Bioanalytical Systems, Inc. | Movement--responsive system for conducting tests on freely-moving animals |
| US6856666B2 (en) * | 2002-10-04 | 2005-02-15 | Ge Medical Systems Global Technology Company, Llc | Multi modality imaging methods and apparatus |
| US20040225222A1 (en) * | 2003-05-08 | 2004-11-11 | Haishan Zeng | Real-time contemporaneous multimodal imaging and spectroscopy uses thereof |
| US7412028B2 (en) * | 2004-01-20 | 2008-08-12 | Ge Medical Systems, Israel Ltd. | Methods and system for multi-modality imaging |
| US7734325B2 (en) * | 2004-09-21 | 2010-06-08 | Carestream Health, Inc. | Apparatus and method for multi-modal imaging |
| CN101080746B (en) * | 2004-12-15 | 2012-07-04 | 皇家飞利浦电子股份有限公司 | Registration of multi-modality images |
-
2006
- 2006-12-01 CN CNB2006101442847A patent/CN100450440C/en not_active Expired - Fee Related
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101584576B (en) * | 2009-07-06 | 2013-01-02 | 上海展弈信息科技有限公司 | Automatic detecting system for spontaneous pain behaviours of animals |
| CN101653355B (en) * | 2009-09-11 | 2012-01-11 | 华中科技大学 | Living small animal imaging system and imaging method |
| CN102753962A (en) * | 2010-11-30 | 2012-10-24 | 中国科学院自动化研究所 | System and method for multimode three dimensional optical tomography based on specificity |
| CN102753962B (en) * | 2010-11-30 | 2014-10-08 | 中国科学院自动化研究所 | System and method for multimode three dimensional optical tomography based on specificity |
| CN102319058A (en) * | 2011-09-09 | 2012-01-18 | 清华大学 | Three-mode small animal imaging system integrating fluorescence, nuclei and X rays |
| CN102319058B (en) * | 2011-09-09 | 2013-03-06 | 清华大学 | Three-mode small animal imaging system integrating fluorescence, nuclei and X rays |
| CN103188989A (en) * | 2012-04-28 | 2013-07-03 | 清华大学 | Method for reconstructing dynamic fluorescence molecular tomography |
| WO2013159250A1 (en) * | 2012-04-28 | 2013-10-31 | 清华大学 | 4d fluorescence molecular tomography image reconstruction method |
| CN103188989B (en) * | 2012-04-28 | 2015-05-27 | 清华大学 | Method for reconstructing dynamic fluorescence molecular tomography |
| CN102871679A (en) * | 2012-09-20 | 2013-01-16 | 清华大学 | In-vivo multi-mode imaging detecting system with resolution being at least 50 mu m |
| CN103610471B (en) * | 2013-12-16 | 2015-10-28 | 中国科学院自动化研究所 | A kind of Optical multi-mode state imaging system and method |
| CN104873212A (en) * | 2015-04-05 | 2015-09-02 | 清华大学 | Dual-mode coaxial in-vivo imaging method and dual-mode coaxial in-vivo imaging system |
| CN104888356A (en) * | 2015-06-30 | 2015-09-09 | 瑞地玛医学科技有限公司 | Image guide and breathing exercise analysis method |
| CN104888356B (en) * | 2015-06-30 | 2018-03-02 | 瑞地玛医学科技有限公司 | Image-guided and breath Motion Estimation system |
| CN106199673A (en) * | 2016-09-07 | 2016-12-07 | 武汉京邦科技有限公司 | A kind of bimodulus positron imaging machine based on event count |
| CN107242860A (en) * | 2017-07-25 | 2017-10-13 | 京东方科技集团股份有限公司 | Fluorescent molecular tomography system and method |
| US11206982B2 (en) | 2017-07-25 | 2021-12-28 | Boe Technology Group Co., Ltd. | Apparatus and method for fluorescence molecular tomography |
| CN108387519A (en) * | 2018-05-03 | 2018-08-10 | 上海市质子重离子临床技术研发中心 | Microscopic system is just set in up-conversion luminescence near-infrared and the multi-functional wide field of colour imaging |
| CN109998480A (en) * | 2019-02-01 | 2019-07-12 | 中国科学院苏州生物医学工程技术研究所 | Internal drug Vivo Studies on Screening system |
| CN113109307A (en) * | 2021-04-01 | 2021-07-13 | 南京超维景生物科技有限公司 | Displacement control method and device, electronic equipment and multi-photon fluorescence imaging equipment |
| CN113827194A (en) * | 2021-11-01 | 2021-12-24 | 锘海生物科学仪器(上海)有限公司 | Near-infrared two-zone living body fluorescence imaging system |
| CN116942078A (en) * | 2022-04-19 | 2023-10-27 | 上海天能生命科学有限公司 | Living body imaging system |
| CN116942078B (en) * | 2022-04-19 | 2024-03-29 | 上海天能生命科学有限公司 | Living body imaging system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100450440C (en) | 2009-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100450440C (en) | Rotary platform type animals in-vivo multi-mode imaging detection system | |
| CN101653355B (en) | Living small animal imaging system and imaging method | |
| CN207336917U (en) | Microscope | |
| CA2956230C (en) | Multi-modal optical imaging system for tissue analysis | |
| CN105308949B (en) | Image acquiring device, image acquiring method and recording medium | |
| CN104783757B (en) | Focus on scanning device | |
| US20110001036A1 (en) | system for imaging an object | |
| US20090091566A1 (en) | System and methods for thick specimen imaging using a microscope based tissue sectioning device | |
| CN102871679B (en) | In-vivo multi-mode imaging detecting system with resolution being at least 50 mu m | |
| Yang et al. | Real-time molecular imaging of near-surface tissue using Raman spectroscopy | |
| US20060291042A1 (en) | Optical scanning zoom microscope with high magnification and a large field of view | |
| CN104570315A (en) | Colored three-dimensional tomography micro-imaging system and method based on structural illumination | |
| CN101365377A (en) | Continuous dynamically collecting type small animal induced fluorescent molecular image-forming system and method | |
| CN102135661A (en) | Confocal microscope for imaging of selected locations of the body of a patient | |
| CN109001898A (en) | A kind of multi-angle three-dimensional super-resolution mating plate fluorescence microscope of miniaturization | |
| US10895726B2 (en) | Two-dimensional and three-dimensional fixed Z scanning | |
| CN106023291A (en) | Imaging device and method for quickly acquiring 3D structure information and molecular phenotype information of large sample | |
| CN111279200B (en) | Slide holder turntable | |
| CN110140129A (en) | It is imaged using the imaging of the low resolution slide glass of double optics path and single imaging sensor and slide labels imaging and high-resolution slide glass | |
| CN112114423A (en) | Portable full-automatic multi-mode microscopic imaging device | |
| CN108469429A (en) | A kind of bimodal Raman-optical projection computed tomography (SPECT) system | |
| CN104939858B (en) | A kind of multi-modal computed tomography (SPECT) system and method for combination X-ray and fluorescence | |
| CN207166606U (en) | Medical imaging extraction element and system | |
| Huang et al. | Robotic-arm-assisted flexible large field-of-view optical coherence tomography | |
| CN111149000B (en) | Turntable for 2X3 and 1X3 slides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090114 Termination date: 20191201 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |