CN1977902A - Injection total saponins of paeonia powder without additive material - Google Patents
Injection total saponins of paeonia powder without additive material Download PDFInfo
- Publication number
- CN1977902A CN1977902A CN 200510122943 CN200510122943A CN1977902A CN 1977902 A CN1977902 A CN 1977902A CN 200510122943 CN200510122943 CN 200510122943 CN 200510122943 A CN200510122943 A CN 200510122943A CN 1977902 A CN1977902 A CN 1977902A
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- Prior art keywords
- radix paeoniae
- paeoniae rubra
- total glycosides
- rubra total
- injectable powder
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Abstract
The present invention relates to a red peony total glycoside powder injection preparation containing any additive auxiliary material so as to raise stability and safety of said injection preparation. The described red peony total glycoside is any one of glycoside components obtained by extracting paeonia lactiflora pall. Or paeonia veitchii lynch or combination of arbitrary several kinds. In the invented red peony total glycoside powder injection preparation the red peony total glycoside content is 80-99.9%, in which the paeoniflorin content is 70-99.9%. Besides, it also contains small quantity of benzoic acid, paenol and water. Said powder injection preparation has the effect for resisting thrombosis, and can be used for curing the diseases of cerebral thrombotic infarct, etc.
Description
Technical field
The invention belongs to Chinese medicine and natural drug research field.
Background technology
Radix Paeoniae Rubra is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch, has clearing away heat and cooling blood, the effect of eliminating stasis to stop pain.The clinical treatment that is usually used in cardiovascular and cerebrovascular disease.Radix Paeoniae Rubra total glycosides is its main active, total glycosides comprises peoniflorin (paeoniflorin), lactone glucoside of Radix Paeoniae (albiflorin) oxypaeoniflorin (oxypaeoniflorin), benzoylpaeoniflorin (benzoylpaeoniflorin), and a spot of benzoic acid (benzoicacid).Modern pharmacological research shows that Radix Paeoniae Rubra total glycosides has the inductive rat platelet aggregation of remarkable inhibition ADP, obviously prolongs the clotting time of experimental animal; Have effects such as the external thrombus of inhibition.
At present domestic disclosed relevant Radix Paeoniae Rubra total glycosides injection or the patent application of injection powder pin all contain adjuvant in the preparation.In the injection Radix Paeoniae Rubra total glycosides injectable powder that characteristics of the present invention are to prepare, remove and contain Radix Paeoniae Rubra total glycosides, a small amount of benzoic acid and moisture, do not contain any interpolation adjuvant.
Summary of the invention
The present invention passes through certain preparation method with Radix Paeoniae Rubra total glycosides, makes the injection Radix Paeoniae Rubra total glycosides injectable powder that does not contain any interpolation adjuvant, to improve stability of formulation and safety.
Radix Paeoniae Rubra total glycosides of the present invention is meant and obtains from ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch, comprise peoniflorin (paeoniflorin), lactone glucoside of Radix Paeoniae (albiflorin), oxypaeoniflorin (oxypaeoniflorin), benzoylpaeoniflorin (benzoylpaeoniflorin), Hydroxy peoniflorin (), the former glycosides of paeonol (paeonolide), Cortex Moutan phenolic glycoside (paeoniside), peonin (paeonin), galloylpaeoniflorin (galloylpaeoniflorin), in the lacdtlorin glycoside compositions such as (lactiflorin) any one and several combination arbitrarily.
In the injection Radix Paeoniae Rubra total glycosides injectable powder of the present invention, the content of Radix Paeoniae Rubra total glycosides is 80～99.9%, and wherein content of paeoniflorin is 70～99.9%.
Injection Radix Paeoniae Rubra total glycosides injectable powder of the present invention still contains a spot of benzoic acid (benzoic acid) and paeonol (paenol) except that containing above-mentioned Radix Paeoniae Rubra total glycosides.
The characteristics of injection Radix Paeoniae Rubra total glycosides injectable powder of the present invention are: except that containing mentioned component and moisture, do not contain any interpolation adjuvant.
Radix Paeoniae Rubra total glycosides extracting method of the present invention, can be prepared by the known method of those skilled in the art, for example: disclosed extracting method in 664～665 pages of " Chinese patent medicine " 1999 the 21st the 12nd phases of volume: Radix Paeoniae Rubra is earlier with 70% ethanol extraction, adsorb with macroporous adsorptive resins after reclaiming ethanol, the washing back is with 20% ethanol elution, collect pure washing liquid, concentrating under reduced pressure promptly gets Radix Paeoniae Rubra total glycosides.
Preparation method of the present invention can prepare by the known preparation technique of those skilled in the art, for example Freeze Drying Technique, spray drying technology, vacuum drying technique, far-infrared drying technology, microwave drying technology etc.The present invention preferably is solvent with water for injection, dissolving back aseptic filtration, and packing, lyophilization, promptly.
Experimentation proves, injection Radix Paeoniae Rubra total glycosides (powder pin) can improve middle cerebral artery blocking-up (MCAO) back Rats survival rate, improves the neuroethology scoring of MCAO rat after 24 hours, reduce the cerebral infarction rate, to the influence of cerebral index and brain water content not significantly (P＞0.05); Histopathological examination shows: the brain tissue impairment due to the injection Radix Paeoniae Rubra total glycosides centering artery occlusion has the certain protection effect; But the increased SOD activity, and NOS activity and MDA content are not had remarkable influence (P＞0.05); The neuroethology scoring of ischemia-reperfusion rat be can reduce, cerebral infarction rate, brain water content and cerebral index reduced; The cerebral tissue pathological examination shows: the injection Radix Paeoniae Rubra total glycosides to ischemia-reperfusion after the degeneration, the formation of downright bad and softening kitchen range of cerebral tissue CA1-CA3 hippocampal neuron (pyramidal cell) improve significantly; Energy increased SOD activity reduces NOS; Can prolong the mice time-to-live of acute cerebral ischemia; Weight in wet base, dry weight to rat arteriovenous shut thrombosis have tangible reduction effect; Reduce hematoblastic aggregation rate, reduce the erythrocyte aggregation ability, strengthen erythrocyte deformability; Prolong thrombinogen and thrombin time; Reduce whole blood viscosity (in cut, low cutting), plasma viscosity; Reduce anesthetized dog DAP, MAP, total oxygen consumption and total peripheral vascular resistance; Reduce the anesthetized dog cerebral vascular resistance, the cerebral blood flow increasing amount.
Above experimental result proves that the injection Radix Paeoniae Rubra total glycosides has anti thrombotic action, can be used as the active drug of treatment cerebral vessels embolism.
The object of the present invention is to provide a kind of injection Radix Paeoniae Rubra total glycosides injectable powder, said preparation has steady quality, convenient drug administration, the advantage of determined curative effect; When the preparation injectable powder, do not add any skeleton adjuvant simultaneously, make preparation safer, reduce because the untoward reaction of using adjuvant to cause.
Embodiment 1
Prescription
Radix Paeoniae Rubra total glycosides 120g
Water for injection adds to 4000mL
Lyophilizing is made 1000
[method for making] is dissolved in water for injection with Radix Paeoniae Rubra total glycosides, and the filter membrane aseptic filtration with 0.22 μ m is sub-packed in the cillin bottle, puts lyophilization in the freezer dryer, gland, and packing, promptly.
Embodiment 2
Prescription
Radix Paeoniae Rubra total glycosides 240g
Water for injection adds to 4000mL
Lyophilizing is made 1000
[method for making] is dissolved in water for injection with Radix Paeoniae Rubra total glycosides, and the filter membrane aseptic filtration with 0.22 μ m is sub-packed in the cillin bottle, puts lyophilization in the freezer dryer, gland, and packing, promptly.
Embodiment 3
Get Radix Paeoniae Rubra total glycosides, be mixed with 5% solution with water for injection, in the gnotobasis below 100 grades, ultrafiltration or aseptic filtration, the sterile liquid spray drying obtains aseptic Radix Paeoniae Rubra total glycosides powder, is sub-packed in cillin bottle, every 120mg or 240mg, roll lid, packing, promptly.
Claims (7)
1, a kind of is the injection Radix Paeoniae Rubra total glycosides injectable powder of active component with the Radix Paeoniae Rubra total glycosides.
2, the described injection Radix Paeoniae Rubra total glycosides of claim 1 injectable powder is characterized in that not containing in the preparation any interpolation adjuvant.
3, the described injection Radix Paeoniae Rubra total glycosides of claim 1 injectable powder, it is characterized in that described active component Radix Paeoniae Rubra total glycosides is meant obtains from cohosh Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch, the mixture of any one or several glycosides compound.
4, the described injection Radix Paeoniae Rubra total glycosides of claim 1 injectable powder is characterized in that still containing a small amount of benzoic acid except that Radix Paeoniae Rubra total glycosides.
5, the described injection Radix Paeoniae Rubra total glycosides of claim 1 injectable powder is characterized in that containing Radix Paeoniae Rubra total glycosides, the benzoic acid sum is 70～99.9% weight, and wherein paeoniflorin content is 70～99.9%, and its surplus is a moisture.
6, the described injection Radix Paeoniae Rubra total glycosides of claim 1-5 injectable powder can adopt known extracting method of those skilled in the art and preparation technique preparation.
7, the described injection Radix Paeoniae Rubra total glycosides of claim 1-6 injectable powder powder pin is characterized in that having anti thrombotic action, can be used for the cerebral vessels embolism disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510122943 CN1977902A (en) | 2005-12-09 | 2005-12-09 | Injection total saponins of paeonia powder without additive material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510122943 CN1977902A (en) | 2005-12-09 | 2005-12-09 | Injection total saponins of paeonia powder without additive material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1977902A true CN1977902A (en) | 2007-06-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510122943 Pending CN1977902A (en) | 2005-12-09 | 2005-12-09 | Injection total saponins of paeonia powder without additive material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1977902A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105640974A (en) * | 2016-01-25 | 2016-06-08 | 河南大学 | Application of albiflorin to preparation of antithrombotic drug |
-
2005
- 2005-12-09 CN CN 200510122943 patent/CN1977902A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105640974A (en) * | 2016-01-25 | 2016-06-08 | 河南大学 | Application of albiflorin to preparation of antithrombotic drug |
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| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |