CN1975377A - Biological sensor for fast optical detecting hemoglobin - Google Patents

Biological sensor for fast optical detecting hemoglobin Download PDF

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Publication number
CN1975377A
CN1975377A CN 200510126007 CN200510126007A CN1975377A CN 1975377 A CN1975377 A CN 1975377A CN 200510126007 CN200510126007 CN 200510126007 CN 200510126007 A CN200510126007 A CN 200510126007A CN 1975377 A CN1975377 A CN 1975377A
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CN
China
Prior art keywords
biology sensor
reaction film
pressing plate
bonding agent
glue
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Pending
Application number
CN 200510126007
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Chinese (zh)
Inventor
何保山
蔡新霞
周爱玉
刘春秀
郭宗慧
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Electronics of CAS
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Institute of Electronics of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Electronics of CAS filed Critical Institute of Electronics of CAS
Priority to CN 200510126007 priority Critical patent/CN1975377A/en
Publication of CN1975377A publication Critical patent/CN1975377A/en
Pending legal-status Critical Current

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  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

This invention disclosed a biosensor for haemoglobin testing which consists of transparent board, reaction film, base and bond. There is a symbol line on the base; the film was fixed on the base by the line; the board was covered on the film. When testing, drop 10 muL blood sample on the center of the film and the outcome would turn out in 60 seconds. It works efficiently and precisely. Also, it is brief, easy to handle and cost saving.

Description

Biological sensor for fast optical detecting hemoglobin
Technical field
The present invention relates to the medical clinic applications technical field, is a kind of biological sensor for fast optical detecting hemoglobin, can be accurate, quick, quantitative on medicine body and blood screening detect content of hemoglobin in the blood of human body.
Background technology
To the detection of haemoglobin in the blood of human body, use all having very widely aspect the diagnosis of hypoferric anemia symptom and the blood screening.At present, the detection method of relevant haemoglobin depends on some large-scale Biochemical Analyzers mostly, and these instrument ubiquity test durations are longer, and blood sampling volume is big, and complicated operation is not suitable for layman's operation, and costs an arm and a leg, and carries drawbacks such as inconvenience; Though current some haemoglobins that are used for aspect the voluntary blood donation that occurred on market detect bottle and test card, but these methods can only be confined to the examination aspect, can not provide the true measurement of haemoglobin exactly, and judged result is easy to be subjected to artificial factor, causes the examination result inaccurate.
Summary of the invention
Purpose of the present invention is exactly at above deficiency, a kind of simplicity of design is provided, with low cost, accurately and reliably, analysis speed is fast, and the sampling trace, belongs to disposable use, no cross-infection is well suited for carrying out the biological sensor for fast optical detecting hemoglobin that field quick detection is used on clinical medicine.
For achieving the above object, technical solution of the present invention provides a kind of biological sensor for fast optical detecting hemoglobin, comprises transparent pressing plate, reaction film, substrate and bonding agent four parts; It is carved with markings at substrate one end, and reaction film is fixed in an end of substrate surface by bonding agent according to markings, transparent pressing plate by bonding agent be sealed on reaction film above, constitute complete biology sensor.
Described biology sensor, its described substrate, being white light-proof material, is optionally, polyphenylene sulfide fine from polyamide, styrene-butadiene-propylene, poly terephthalic acid second two fat, nylon 66, polyoxymethylene, polyimide, polyvinyl chloride, ultra-high molecular weight polyethylene, the polyetheretherketonematerials materials to get a kind of making.
Described biology sensor, its described substrate, thickness is 0.10~0.30mm, and width is 8.00~10.00mm, and length is 70.00~100.00mm; Preferably: thick 0.20mm, wide 8.00mm, long 80.00mm.
Described biology sensor, its described reaction film, being white light-proof material, is to choose wantonly to get a kind of making from short fiber, high-intensity fiber, water-soluble fibre, negative-ion fiber, paper fiber, mekralon, nano bamboo-carbon fibre, NACF, glass fibre, alumina-silicate ceramic fibre, tissue paper fibrous material.
Described biology sensor, its described reaction film, thickness is even, and thickness is 0.05~0.20mm, and width is 8.00~11.00mm, and length is 7.00~10.00mm; Preferably: thick 0.10mm, wide 8.00mm, long 8.00mm.
Described biology sensor, its described bonding agent, be from UV ultraviolet ray glue, anoxic glue, epoxide resin AB glue, plane flexible glue, Instant cement-502, milky white adhesive, toluene glue optional get a kind of.
Described biology sensor, its described transparent pressing plate is to choose wantonly to get a kind of making from polypropylene, teflon, polybutylene terephthalate, polycarbonate, nylon 9 01, Kynoar, polysulfones-polyethersulfone-polyarylsulfone.
Described biology sensor, its described transparent pressing plate is colourless transparent material, and thickness is 0.10~0.30mm, and width is 6.00~9.00mm, and length is 30.00~60.00mm; Preferably: thick 0.15mm, wide 8.00mm, long 40.00mm.
Described biology sensor during its described detection, is got whole blood sample to be measured and is dripped central authorities at reaction film, after all spreading apart Deng blood sample, with transparent pressing plate by bonding agent be sealed on reaction film above, by optical detection, can quantitatively show the haemoglobin test result.
Described biology sensor, it is described gets whole blood sample to be measured, is 10 μ L.
Described biology sensor, its described demonstration haemoglobin test result was to show about 60 seconds.
Description of drawings
Fig. 1 is the structural representation of biological sensor for fast optical detecting hemoglobin of the present invention.
Embodiment
As shown in Figure 1, biological sensor for fast optical detecting hemoglobin of the present invention, by transparent pressing plate 1, substrate 2, reaction film 3 and and bonding agent 4 four parts constitute.Substrate 2 one ends are carved with markings, and reaction film 3 is tiled in an end of substrate 2 by bonding agent 4 according to markings, the effect of transparent pressing plate 1 by bonding agent 4 be sealed on reaction film 3 above.
Substrate 2, optionally, polyphenylene sulfide fine, poly terephthalic acid second two fat, nylon 66, polyoxymethylene, polyimide, polyvinyl chloride, ultra-high molecular weight polyethylene, the polyetheretherketonematerials materials get a kind of making from polyamide, styrene-butadiene-propylene, selected base material white is light tight, thickness is 0.10~0.30mm, preferred 0.20mm, width is 8.00~10.00mm, preferred 8.00mm, length 70.00~100.00mm, preferred 80.00mm.Substrate 2 one ends are carved markings.
Reaction film 3 is chosen wantonly from short fiber, high-intensity fiber, water-soluble fibre, negative-ion fiber, paper fiber, mekralon, nano bamboo-carbon fibre, NACF, glass fibre, alumina-silicate ceramic fibre, tissue paper fibrous material and is got a kind of making, selected reaction film material white is light tight, thickness is even, thickness is 0.05~0.20mm, preferred 0.10mm, good water absorption and dry back are indeformable, and length is 7.00~10.00mm, preferred 8.00mm; Width is 8.00~11.00mm, preferred 8.00mm.
Bonding agent 4 be from UV ultraviolet ray glue, anoxic glue, epoxide resin AB glue, plane flexible glue, Instant cement-502, milky white adhesive, toluene glue optional get a kind of.
Transparent pressing plate 1 be from polypropylene, teflon, polybutylene terephthalate, polycarbonate, nylon 9 01, Kynoar, polysulfones-polyethersulfone-polyarylsulfone optional get a kind of, selected transparent pressing plate material is wanted water white transparency, light transmission is good, thickness is 0.10~0.30mm, preferred 0.15mm, length is 30.00~60.00mm, preferred 40.00mm, width is 6.00~9.00mm, preferred 8.00mm.
During with biosensor test of the present invention, get whole blood sample 10 μ L to be measured and drip central authorities at reaction film 3, wait blood sample all to spread apart after, transparent pressing plate 1 by bonding agent 4 be sealed on reaction film 3 above, by optical detection, in about 60 seconds, can quantitatively show the haemoglobin test result.
This biological sensor for fast optical detecting hemoglobin is simplicity of design not only, and is easy to operate, is easy to carry about with one, the result accurately and reliably, analysis speed is fast, and sampling trace, belong to disposable use, avoided the cross-infection between individuality, be well suited on clinical medicine, carrying out field quick detection and use.
Above embodiment is for illustrative purposes, rather than limitation of the present invention.On the basis of the above description; the present invention can be many modifications and changes; institute makes improvements and changes, and select other functional material for use, improve sensor structure, directly transparent pressing plate being sealed on the first-class method of reaction film all should be within claim protection domain of the present invention.

Claims (11)

1. a biological sensor for fast optical detecting hemoglobin comprises transparent pressing plate, reaction film, substrate and bonding agent four parts; It is characterized in that, be carved with markings at substrate one end, reaction film is fixed in an end of substrate surface by bonding agent according to markings, transparent pressing plate by bonding agent be sealed on reaction film above, constitute complete biology sensor.
2. biology sensor as claimed in claim 1, it is characterized in that, described substrate, being white light-proof material, is optionally, polyphenylene sulfide fine from polyamide, styrene-butadiene-propylene, poly terephthalic acid second two fat, nylon 66, polyoxymethylene, polyimide, polyvinyl chloride, ultra-high molecular weight polyethylene, the polyetheretherketonematerials materials to get a kind of making.
3. biology sensor as claimed in claim 2 is characterized in that, described substrate, and thickness is 0.10~0.30mm, and width is 8.00~10.00mm, and length is 70.00~100.00mm; Preferably: thick 0.20mm, wide 8.00mm, long 80.00mm.
4. biology sensor as claimed in claim 1, it is characterized in that, described reaction film, being white light-proof material, is to choose wantonly to get a kind of making from short fiber, high-intensity fiber, water-soluble fibre, negative-ion fiber, paper fiber, mekralon, nano bamboo-carbon fibre, NACF, glass fibre, alumina-silicate ceramic fibre, tissue paper fibrous material.
5. biology sensor as claimed in claim 4 is characterized in that, described reaction film, and thickness is even, and thickness is 0.05~0.20mm, and width is 8.00~11.00mm, and length is 7.00~10.00mm; Preferably: thick 0.10mm, wide 8.00mm, long 8.00mm.
6. biology sensor as claimed in claim 1 is characterized in that, described bonding agent, be from UV ultraviolet ray glue, anoxic glue, epoxide resin AB glue, plane flexible glue, Instant cement-502, milky white adhesive, toluene glue optional get a kind of.
7. biology sensor as claimed in claim 1, it is characterized in that, described transparent pressing plate is to choose wantonly to get a kind of making from polypropylene, teflon, polybutylene terephthalate, polycarbonate, nylon 9 01, Kynoar, polysulfones-polyethersulfone-polyarylsulfone.
8. biology sensor as claimed in claim 7 is characterized in that, described transparent pressing plate is colourless transparent material, and thickness is 0.10~0.30mm, and width is 6.00~9.00mm, and length is 30.00~60.00mm; Preferably: thick 0.15mm, wide 8.00mm, long 40.00mm.
9. biology sensor as claimed in claim 1, it is characterized in that, during described detection, get the central authorities of whole blood sample dropping to be measured at reaction film, after all spreading apart Deng blood sample, with transparent pressing plate by bonding agent be sealed on reaction film above, by optical detection, can quantitatively show the haemoglobin test result.
10. biology sensor as claimed in claim 9 is characterized in that, describedly gets whole blood sample to be measured, is 10 μ L.
11. biology sensor as claimed in claim 9 is characterized in that, described demonstration haemoglobin test result was to show about 60 seconds.
CN 200510126007 2005-11-28 2005-11-28 Biological sensor for fast optical detecting hemoglobin Pending CN1975377A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 200510126007 CN1975377A (en) 2005-11-28 2005-11-28 Biological sensor for fast optical detecting hemoglobin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 200510126007 CN1975377A (en) 2005-11-28 2005-11-28 Biological sensor for fast optical detecting hemoglobin

Publications (1)

Publication Number Publication Date
CN1975377A true CN1975377A (en) 2007-06-06

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108463711A (en) * 2015-11-18 2018-08-28 雷迪奥米特医学公司 Optical sensor for detecting the free hemoglobin in whole blood sample

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108463711A (en) * 2015-11-18 2018-08-28 雷迪奥米特医学公司 Optical sensor for detecting the free hemoglobin in whole blood sample
US11079317B2 (en) 2015-11-18 2021-08-03 Radiometer Medical Aps Optical sensor for detection of free hemoglobin in a whole blood sample

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