CN1970756A - Human liver related gene - Google Patents

Abstract

The invention discloses a relative gene of human liver and pathogenic factor and important action in the drug to treat liver disease.

Description

Human liver related gene

Technical field

The present invention relates to biological technical field, particularly, relate to a genoid, relate in particular to human liver related gene.

Background technology

Liver is a digestive gland maximum in the human body.It also is the junction centre of body intracellular metabolic.According to estimates, the chemical reaction that takes place in liver has more than 500 kinds, gives corresponding treatment even experiment showed, animal after extracing liver fully, at most also can only survive more than 50 hour.This explanation liver is the requisite vitals of active that earn a bare living.The volume of blood flow of liver is very abundant, accounts for kinemic 1/4.The volume of blood flow that per minute enters liver is 1000-1200ml.The major function of liver is to carry out the decomposition of sugar, storage glycogen; Participate in the metabolism of protein, fat, VITAMIN, hormone; Detoxifcation; Secretion of bile; Engulf, defensive enginery; Make thrombin; Regulate Q volume of blood and water-electrolyte balance; Produce heat etc.Also has hemopoietic function at embryo's liver in period.

The liver eqpidemic disease is divided into hepatitis, liver cirrhosis, fatty liver, liver cancer etc.Modern medicine does not directly cause hepatocellular infringement after experiment showed, that hepatopathy virus is invaded human body, just absorbs nutrition and depend on for existence in liver cell, and duplicate in liver cell, breed." component " of its replication-competent virus are released on the liver plasma membrane as surface antigen (HBsAg), e antigen (HBeAg), cause that the human immune system produces immune response to these antigenic substances, and this reaction causes hepatocellular damage, necrosis.Immunoreactive power is decided by liver damage degree and clinical symptom weight.That this is caused by virus, immunity system is to hepatocellular war, makes about 25% patient's liver become the unbroken battlefield of the flames of war, and the damage of liver increases the weight of thus.The harm of hepatopathy never only only limits to liver itself, and it can also cause other multiple disease.Common has: (1) diabetes; (2) pancreatitis; (3) biliary tract infection; (4) functional renal failure; (5) courage sweat ephrosis; (6) glomerulonephritis; (7) renal tubule acidosis; (8) hemolytic anemia; (9) aplastic anemia; (10) myocarditis and pericarditis; (11) arteritis nodosa; (12) peptide ulceration; (13) spontaneous peritonitis; (14) sex hormone metabolism disorder; (15) thyroid function changes; (16) liver property osteopathy, or the like.Hepatopathy not only works the mischief to patient's body even life, and also is very heavy to the strike on the patients ' psychological.No matter be liver problem sufferer or virus carrier, all can be had a strong impact at life, social, aspect such as hunt for a job, enter a higher school.

But the sequence of transcriptional expression in the biological gene group (being gene) only accounts for the 3-5% of total sequence, and this part sequence is measured, and will directly cause the discovery of new gene, and obtains information the closest with the industrialization relation in the genome.

Human liver related gene is meant the genes involved of expressing in human liver, it is relevant with some hepatic diseases, and therefore, the research human liver related gene is significant to the medicine of the pathogeny of exploring hepatic diseases and development hepatopathy.

Summary of the invention

The technical problem to be solved in the present invention provides human liver related gene.

The technical problem to be solved in the present invention is achieved through the following technical solutions:

The invention provides human liver related gene, it comprises the gene of following sequence:

(a) sequence shown in SEQ ID No.1～SEQ ID No.30;

(b) complementary sequence of every sequence in the sequence shown in SEQ ID No.1～SEQ ID No.30;

(c) with the sequence shown in SEQ ID No.1～SEQ ID No.30 in every sequence the sequence of at least 70% homology is arranged, and

(d) one or several combination in above-mentioned (a)～(c).

Preferably, described sequence comprises having SEQ ID No.1～sequence shown in the SEQ ID No.30.

The present invention also provides a kind of probe molecule, and described probe molecule contains about 8-100 successive Nucleotide in the above-mentioned sequence.

Human liver related gene of the present invention plays a significant role in the medicine that hepatic diseases is treated in the pathogenesis and the exploitation of research hepatic diseases.

Embodiment

Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only are used to the present invention is described rather than limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example, usually according to people such as normal condition such as Sambrook, molecular cloning: laboratory manual (New York:Cold Spring HarborLaboratory Press, 1989) condition described in, or the condition of advising according to manufacturer.

Embodiment 1

The separation of the mRNA of human liver organization

Separate tissue (Tissue isolation): liver derives from 5 adult mans, after the hepatotomy operation, liver organization is placed the freezing preservation of liquid nitrogen immediately.

The separation of mRNA (mRNA isolation): take out liver organization, grind, add the 50ml pipe that fills lysate, fully after the vibration with mortar, move into again in the glass homogenizer, move to 50ml after the homogenate and newly manage, extracted total RNA (TRIzol Reagents, Gibco, NY, USA).Identify total RNA quality with the denaturing formaldehyde gel electrophoresis.Cellulose column with band Oligod (T) separates mRNA among total RNA, quantitatively.

Embodiment 2

The structure in cDNA library (Constuction of cDNA library)

With mRNA is template, synthetic double chain cDNA.After mending flat end, add the joint that contains the EcoRI point of contact.Behind the phosphorylation EcoRI end, use XhoI digestion with restriction enzyme 1.5 hours, carry out segment again and separate.Cross the fragment of post screening length＞500bp, use the phenol-chloroform extracting, ethanol sedimentation, the sterilized water dissolving, be connected to Uni-ZAP XR carrier (Strategene, CA9203, USA), with ZAP-cDNA Gigapack III Gold Cloning Kit (Strategene, CA9203 USA) packs, and the host bacterium is used XL 1 Blue MRF ' (Strategene, CA9203, USA) bacterium.Coated plate is also measured titre.

Embodiment 3

Order-checking and database are set up (Seqencing and Database Constructing)

Select the clone who has the external source fragment to insert in the library, amplification back extracting plasmid (Qiagen Germany), with T3 and T7 universal primer as 3 ' and 5 ' end, adopt and stop thing fluorescent mark (Big-Dye, Perkin-Elmer, USA) method, (Perkin-Elmer carries out the EST large scale sequencing on USA) at ABI 377 sequenators.Sequencing result is removed the carrier sequence with FACTURA software, is transferred to the processing of carrying out next step on the SUN Ultra 450Server.All sequence informations are used the GCG software package again, and (Wisconsin group, USA) BLAST in and the existing database of FASTA software search (Genebank+EMBL) are lower than 95% sequence with no homology or homology and are considered as new gene and set up database.

Embodiment 4

The full-length clone of gene (Cloning of Full-length cDNA)

On the new gene fragment order information basis that obtains, carry out the cDNA full-length clone, carry out in two stages:

(1) " electronic cloning " (Electronic Cloning)

Search the dbEST database with new gene fragment order as probe, with overlap＞50bp, homology is at (the Expressed Sequence Tag of the expressed sequence tag more than 98%, being called for short " EST ") sequence thinks same sequence (Consensus Sequence), take out and connect with AUTOASSEMBLER software, part EST can the extension probes sequence.Whether the sequence that is extended with the STRIDER software analysis has complete open reading frame (OpenReading Frame again, ORF), search Genbank or SwissProt whether homology to be arranged on the Nucleotide of determining this sequence and the amino acid levels, to help how differentiate resulting full length gene integrity with BLAST with other species.By the method for electronic cloning, can obtain the full length sequence of people's liver related gene usually.

(2) the terminal rapid amplifying of cDNA (Rapid Amplification of cDNA Ends, RACE)

If do not obtain complete cDNA total length yet by " electronic cloning " method, then at existing sequence 5 ' or 3 ' end design primer, (Clontech Lab, Inc carry out the long range PCR reaction in USA) in human liver Marathon-Ready cDNA library.Then to PCR product cloning, order-checking.The sequence that is extended with AUTOASSEMBLER and STRIDER software analysis has or not complete ORF, as not having, repeats said process until obtaining total length.

(3)RT-PCR

For the known sequences of 5 ' and 3 ' end,, can consider to adopt the method for RT-PCR if the centre has an intersegmental crack (gap) to obtain from existing public database or its data storehouse.At sequence 5 ' end design primer, 3 ' end primer adopts Oligo-dT, increases in the liver total RNA storehouse.Then product is cloned, checked order.Splicing at last just obtains total length.

By being used in combination above-mentioned 3 kinds of methods, can obtain the complete encoding sequence of people's liver associated protein.

Sequence table

＜110〉Research Center of Shanghai Human Genome

＜120〉human liver related gene (8)

<130>NP-10158

<160>30

<210>1

<211>1717

<212>DNA

<213>Homo?sapiens

<400>1

1?gcaattcact?ttggattttc?taatatccca?tttctgagaa?gaatggcaga?ctattgaaca

61?ggtgtatttt?aggtcacgtg?gggactgcat?ccacctgaaa?atccaccgtt?gacttatcag

121?gaaactcaga?gatcaggatc?tttcacagag?tagtctttta?agaagattca?gttgtcaaca

181?gctagcagtc?tctttgccaa?ataattatat?ctgtgacttc?tgaaactatt?tggctgccta

241?aagttaaagg?acttggggaa?agtccttcca?ctgctcttct?gcagtagtgt?cacaccactc

301?agtgcagggc?ccaccaagaa?gaaagcagtg?tcaggatcca?catggcacta?tggtaacttt

361?gtgaaagggg?acattttctc?cctctgaact?tctcttcata?aagtcattgt?gcttcctctt

421?ggggatcacc?tgttcagtct?caatgggctt?tgatgtgctc?ctggatcaag?tgggtggcat

481?ggggagattc?cagatttgtc?tgatagcttt?cttttgcatc?accaacatcc?tactgttccc

541?taatattgtg?ttggagaact?tcactgcatt?cacccctagt?catcgctgct?gggtccccct

601?cctggacaat?gacagtgtgt?ctgacaatga?taccgggacc?ctcagcaagg?atgacctcct

661?gagaatctcc?atcccactgg?actcaaacct?gaggccacag?aagtgtcagc?gctttatcca

721?tccccagtgg?cagctccttc?acctgaacgg?gaccttcccc?aacacaaatg?agccagacac

781?ggagccctgt?gtggatggct?gggtgtacga?cagaagctct?ttcctctcca?ccatcgtgac

841?tgagtgggac?ctggtatgtg?aatctcagtc?actaaaatca?atggttcaat?ccctatttat

901?ggctgggtca?ctgctgggag?gtctaatata?tggccatctt?tcagacaggg?ttggacggaa

961?gatcatatgc?aaattgtgtt?tcctccagct?ggccatctct?aacacctgtg?cggccttcgc

1021?tcccaccttc?cttgtttact?gcatactgcg?cttcttggca?gggttctcca?ccatgactat

1081?tttgggaaac?acttttattc?tcagcttaga?gtggacattg?ccccggtcac?gatctatgac

1141?aataatggtg?ctattatgtt?cctacagtgt?tgggcagatg?ctcctaggag?ggctggcttt

1201?tgccattcag?gactggcaca?tattgcaact?gactgtgtct?acacccataa?ttgtcctctt

1261?cttgtcctct?tggtatgaac?aatctccaca?ttctttgcct?gtaagcgagg?ctatggtaga

1321?catagaaagg?aaaattgtga?cacctgggat?ctgttcggtc?tctggcctag?tcctgagcca

1381?tgatgtccat?agtacctatt?gtgtcacctg?agaagcaaac?aatggaatag?gatgacacta

1441?tatgtgggga?ggctggcact?ttgcattcat?tattttagac?atggaattat?catgaaatta

1501?tttttcttaa?tagaaaaaat?acccacttat?ttttgaagca?aatgtattat?ttatctaact

1561?tttggaatat?tatgtgatgg?agataatttg?ggggcttttg?tcattgtaac?tgagattgaa

1621?tataaggaaa?acacaataaa?tttatctaca?taactattta?aaaaaaaaaa?aaaaaaaaaa

1681?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaa

<210>2

<211>2795

<212>DNA

<213>Homo?sapiens

<400>2

1?attttcgatt?ccactctctt?ccgtttctgt?cgctgcagtc?gtccgcggga?ctccggccgg

61?ttgccggccc?caggcggtgc?ttctccccac?caccgcccag?ctcagctcag?cccagcccag

121?cccactctgc?ccttagaggc?ccttctcccc?aaagacgcac?tccagaagtc?tcgccctcgt

181?gcggctgagg?agcctgggat?cccagacctg?aacaagtgaa?acccccgccc?ctgaagaatg

241?ggtaagacgt?tttcccagct?gggctcttgg?cgggaggatg?agaacaagtc?aatcctgtcc

301?tccaaaccag?ccattggcag?caaggctgtc?aactactcca?gcaccggtag?cagcaagtct

361?ttttgttcct?gtgtgccttg?tgaaggaact?gctgatgcca?gcttcgtgac?ttgtcccacc

421?tgccagggca?gtggcaagat?tccccaagag?ctggagaagc?agttggtggc?tctcattccc

481?tatggggacc?agaggctgaa?gcccaagcac?acgaagctct?ttgtgttcct?ggccgtgctc

541?atctgcctgg?tgacctcctc?cttcatcgtc?tttttcctgt?ttccccggtc?cgtcattgtg

601?cagcctgcag?gcctcaactc?ctccacagtg?gcctttgatg?aggctgatat?ctacctcaac

661?ataacgaata?tcttaaacat?ctccaatggc?aactactacc?ccattatggt?gacacagctg

721?accctcgagg?ttctgcacct?gtccctcgtg?gtggggcagg?tttccaacaa?ccttctccta

781?cacattggcc?ctttggccag?tgaacagatg?ttttacgcag?tagctaccaa?gatacgggat

841?gaaaacacat?acaaaatctg?tacctggctg?gaaatcaaag?tccaccatgt?gcttttgcac

901?atccagggca?ccctgacctg?ttcatacctg?agccattcag?agcagctggt?ctttcagagc

961?tatgaatatg?tggactgccg?aggaaacgca?tctgtgcccc?accagctgac?ccctcaccca

1021?ccatgacctg?tctgctgtcc?ctgtactcca?ggcacctgca?accctggtct?atatctccca

1081?caactccctg?gtgactaagg?aaggactaca?gaggctttgc?caaaggagaa?gccctgcctc

1141?atcacaccct?tacctcccac?cccctcagca?caggaagctt?gctttgaagt?taacttcata

1201?cacacacact?catatcctcc?agtttccccc?agattctttc?aggggctgcc?atcagattct

1261?gcccttggtt?agttttttgt?tttttttttg?gtagagacag?agtctcactg?ttggtccagg

1321?ttggttttga?actcctgggc?tcaagcgatc?ctcccttctt?ggcctcccaa?agcacttgga

1381?ttacagatgt?gagcctgtgc?ctggctggtc?tttcttgagg?aaaatctgac?ctggcatttt

1441?cttgaggcac?cttagattcc?ctggagtggc?acctggcctt?tctgtactga?gcacctggtc

1501?agtctgaagg?gggcatttca?ccccagctcc?atcagggctg?gcagtcccgt?ctgaatgtgg

1561?agagagctgt?agttttatct?ggcttttaaa?acatggacct?gccggctggg?cgcagtggct

1621?tacacctgta?atcccagtac?tttgggaggc?cgaagtgggt?ggatcgcttg?agggcaggag

1681?ttcgtgacca?gcctggtcaa?catggtgaaa?ccttgtctct?actaaaaata?caaaaattag

1741?ctgggtgtgg?tggcatgcgc?ctgtaatccc?ggctactcgg?gaggctgagg?cagcagaatc

1801?acttgaaacc?ggaaggcaga?ggttgcagtg?agccaagatc?gtgcaactgc?actccagcct

1861?gggcaaaaga?gcaaaacttt?gtctcaaaaa?aagactcttt?tcaagttttc?taccctctga

1921?taagaaaatt?tggggatatc?cagtgccatc?tccaaggact?ttcaggggat?catagatgct

1981?tttctgtgcc?tatctgcttt?gaccatgtga?aaaagtgata?gtctgcttct?ctctggtaac

2041?ttgtctgcca?cccatctgat?agtaagatta?gccaaggccc?tttagccctc?tgtcctttct

2101?ggttattgac?tgtccctggt?tcctaggaag?acagagttgt?tctccagcta?aagcgtctcc

2161?tctctataaa?gtagttttac?tattcttttc?atagcaggag?ccaaaatagt?agaggagggg

2221?agagaggcac?ctggcactct?gcgggcctgc?acaggaaaaa?cagagccaaa?gacagaatca

2281?ttgtataaga?tatttattaa?aggagagcct?ctaagtccac?atcctgagcc?catgtgagtg

2341?gacacaggta?ggtaaaacgg?tgggtccagc?tgctgtcatc?tgaaagcctt?caggagatga

2401?agctatcagt?atccagctga?aggctgctgg?gttctgttcc?accaccacct?tagcaccagg

2461?gccctctctg?gtcccagagg?cctcatctct?ccttgggctt?tgacaatgtg?gagcagcaca

2521?tcagcaggga?ctggtctaga?ccctcccttt?cctgtcactt?agctggagct?aagctccaga

2581?taacccctag?gttcccactg?gctcctagta?gaaatagttt?ctgtacttta?gcagaacagg

2641?aaggatattt?gttcattaaa?ggtggcttgg?tcttacagct?gggtgcagtg?gtatatacct

2701?gtagtcccag?ctactcagga?agctgaggtg?agaggatctc?tagagcccag?gaattcaagt

2761?ttaacatgag?cagcaacatt?agcaagaccc?cgttt

<210>3

<211>2759

<212>DNA

<213>Homo?sapiens

<400>3

1?ggcaggggcg?cggcgccggc?tggggccccg?tcttgggtgt?ccacgccgtc?gcctgaccgt

61?tcgagggttt?gatcgccagc?gcagcctcgc?cctgcccaga?cagctgggcc?ctaaggggat

121?agccagcgcc?tttagactta?tcttaaatcg?ggcatcggca?tcaacactta?tttctggggt

181?cctccatgga?aagcagctcc?cgaaacaaca?cccgcccggt?ccgccctccg?ctgcactgga

241?aaaccgcccc?tggacgtttc?tgccgcagtg?tccccctcac?ggagttccgt?ttgtctgctt

301?ggtcggttgt?tctctggagc?cccaggaccc?aggccgcttg?tatgtgcctg?cggccgcacg

361?gccccaacac?gcggacttcg?agcggtaccg?ggagacccgc?gcggcctcct?cggagtggac

421?agtgaagcag?cagctgggct?aggcagtggg?gctgggcctg?cccatgggga?cccgtccacg

481?tctccaggac?atcagcctga?gcctcttcgc?agcctcgttt?tctgttgacc?gagttctgca

541?aggggacgta?gaggaaccac?agcgttcttg?cgcttgagac?cgctgtgatt?ttctgacatt

601?ttggaggcag?aaatgcctgg?ggaaaggccc?acagatgcaa?ctgtcatccc?tagtgccaaa

661?agggaacgga?aagcgattac?ccttgacctc?aaattggaag?tgttacgacg?atttgaagcg

721?ggtgagaagc?tcagtcagat?cgcaaaggcc?ttagatcttg?ctatctctac?agtggcgacc

781?attcgagata?gtaaagaaaa?aatcaaagcg?agttcacaaa?tagctactcc?tctgagagcc

841?tctcggttga?ctcgccatcg?aagtgcagtg?atggagagca?tggagcagct?gctgagcttg

901?tggctggaag?accagagcca?gccaaatgcg?accttgagcg?ccgccatcgt?tcaggagaag

961?gctgagtttg?atgacttaca?gcgtgaacat?ggcgaaggtt?ctcaaacgga?gaggtttcat

1021?gcaagtcaag?ggtggcttgt?gagattcaag?gagtgccact?gtttgcccca?cttcaagatg

1081?aacagcgcag?ctcccagcaa?caaggacatg?tacacagaaa?tgctgaaaag?catcatcgaa

1141?gaaggtgagt?acacccccca?ggtgtcttta?acgtagatga?gacgagactt?gattggaaga

1201?gaatgcccaa?aggaacgttt?atttccgagg?aagagaatgc?tgagccaggg?tttaagtcat

1261?ccaaagatcg?cttgatgctg?ctgcttggtg?gcagtgcagc?tggggacttt?aagttgaagc

1321?ccttactggt?gtaccgctca?gaaacccgca?aggctctgaa?gggttcttga?agcccagttt

1381?gcccgtgatt?tggcgctcca?acagaaaggc?ttgggtgacc?aggagcatct?ttcatgaatg

1441?gttcacttac?tttttttgcc?gttgaaaaat?acagtgccca?aaataatctc?accaacaaag

1501?cactgctcat?actagacagt?gcgtcatgcc?actctgtaaa?tttgagcgac?ctttctgata

1561?actaagagta?gaataccttc?aggccaggcg?cggtggctca?cgcctgtaat?cccagcactt

1621?tgggaggccg?agacgggcgg?atcacctgag?gtcaggagtt?cgagaccagc?ctcaacatgg

1681?agaaaccccg?tctctactaa?aaatacaaat?ttagccgggc?gtggtggtgc?aggcctgtaa

1741?tcccagctac?tcgggaggct?aaagcaggag?aattgcttga?acctgggagg?cggaggttgt

1801?ggtgagccga?gatcgcgcca?ttgcactcca?tcctggacaa?caggagtgaa?actccgtctc

1861?aaaaaaaaaa?aagaaaaaaa?agaagtacaa?gagtataata?ccttcatgac?agtacagctg

1921?actcaatccg?gaccacgtgt?caaggtgtaa?tctcgacctt?gaaagctcat?tatctgagaa

1981?ggacttttca?gcacatccta?gaagcagcgg?atggtgagga?cacagctatg?atcagggaat

2041?tttggagaaa?ctacagcatc?atggatgctg?tggacatggc?catcgcatgg?gaggagctca

2101?aaccagcact?aatgaacagc?atgtggaaga?agatttggcc?tgagtgtgtt?caggcccagc

2161?gtttttccca?ggcagataac?attgcacagc?ttcaaaaaaa?cattgtgacc?cttgccagaa

2221?atgtggcctt?tgaagaggtt?gctgaggctg?ctgtggacca?gttgctgcag?tcccatgaag

2281?aagatctctc?aaatgaggaa?ctgatgcggc?tggaacagga?gctggcagtg?ggggaggagg

2341?agagggaaga?tggtccctgg?gcactgtggc?agctaaccac?aggaagactg?tcggcagccc

2401?tctcacattt?tgaggctggc?ttgtaggtcc?ttgctagtaa?cagccctaat?gatgactgga

2461?aactgagagg?ttccagagaa?atcagtgttg?cagtaaactg?ctagcaggag?ctgtacaatg

2521?agaaaaagcg?ccactcaaaa?caactctctt?aggtcatttt?tcaatgtgtg?taaccaaaag

2581?ttaatcagaa?taaagcggaa?gcaccatgat?gacctcaaca?gtggaggccc?agccaggcct

2641?ccctgctctg?tggtgttgga?catccctgga?aaccttgctg?ttggtatttc?cattttgata

2701?cttgagagca?tcaaattttg?tcattaaaat?gttatttaaa?taaaaaaaaa?aaaaaaaaa

<210>4

<211>1405

<212>DNA

<213>Homo?sapiens

<400>4

1?tgctgcggct?ccgcagcggg?ctgaggcact?ttcgggcaac?acccaatact?cggggctccg

61?ctcggcttct?tcgcgccgag?atgcctaaga?aggctggtgc?gacgaccaag?ggtaaaagcc

121?agagcaagga?accagagaga?ccacttcctc?ccttaggtcc?tgtggcagtt?gatcctaaag

181?gatgcgtcac?catagccatc?catgcaaaac?ctggctccaa?acaaaatgct?gtaacagatt

241?tgacagcaga?ggctgtaaat?gtagctattg?cagcacctcc?atcagaggga?gaggctaatg

301?ctgagctctg?tcggtatctt?tccaaggtcc?tagaactcag?gaagagtgat?gtggttttgg

361?ataagggtgg?taaatctcgt?gaaaaggtgg?tgaagctttt?ggcttctaca?actccagaag

421?agatcttgga?gaaattaaaa?aaggaagcca?aaaaaacata?aaagcaagaa?atgaggccgg

481?gcgcagtggc?tcatgcctgt?aatcccagca?ctttgggagg?ccgtggtggg?cggatcacct

541?gaggtcagga?gttcgagacc?agcctgacca?acatggtgaa?accccatctc?tacgaaaaat

601?acaaaattag?ccagatgtga?tggcgcatgc?ctgtaatccc?agttactcag?gaggctgagg

661?caggagaatc?acttgaacct?ggggggcgga?ggttgcagta?agccgagatc?gcgccgttgc

721?actccagcct?gggcaacaag?agtgaaactc?tctccccccg?aaaaaaaaga?aataaaaaat

781?acatccttga?gaaacttttt?tattgctaat?ggtgaagagg?ctgttaaata?gaaaaatata

841?ctacatgcac?agaagaacat?gggggacata?tatatatgta?tatattcgaa?taagactcca

901?aaaagtagaa?atttaaaaag?tgctatacat?tgcatcaggt?tctaaaatcc?caaaccccaa

961?acagcctgga?acatgttact?ctgatttcat?ggcgttgtaa?aataacagag?ctgggaagaa

1021?tattcaagat?gacctgattt?aacacctttc?attctgttgg?ggggcctttg?atttcctata

1081?tccagaagtt?gagagactta?ctcaagattg?taccatgcaa?gctggcaact?agaacccaaa

1141?tccttggact?acttgttgaa?tgcagttttt?ctagattgta?aattaaaaat?catatctcca

1201?caacggttct?ggaattctgg?ggattgcctt?ctaatccagt?ttacaagtga?cagaaaacct

1261?gttatgctgc?tttgtagtct?taccttagat?ttttaaatgc?ttatttaaat?gtaaaaaaaa

1321?ttttttttta?catcttttaa?agactatatt?taccattttg?ttgaaaaagt?aaagaaaaat

1381?catgacttgt?aattaaatgt?gaatt

<210>5

<211>1665

<212>DNA

<213>Homo?sapiens

<400>5

1?cacgaggaag?acgtggatgg?cgggaattct?cgcttctggc?ctgggtgagc?tagaagggag

61?aagcaaggac?attggagtcc?ctatcaccgg?ttgcctagac?aacttcatgg?gaaggccctt

121?gggaatctga?gatggagcag?gcgaaccctt?tacgtccaga?tggcgagtcc?aaaggaggtg

181?ttttagctca?cttggaaagg?ctagagaccc?aagtgagcag?atcccgtaaa?cagtctgaag

241?agctgcagag?cgtgcaggcc?caggaaggtg?ctcttggaac?caagattcat?aaactaaggc

301?gtctgcgaga?tgagctgagg?gctgtggtgc?ggcaccggcg?agccagcgtg?aaagcatgta

361?ttgccaatgt?agaacccaac?caaacagtgg?agatcaatga?gcaagaagca?ttggaagaga

421?aattggaaaa?tgtgaaagcc?attctgcagg?catatcattt?tacaggcctc?agtggtaaac

481?tgaccagccg?aggagtttgt?gtctgcatca?gtactgcttt?tgaggggaac?ctattggatt

541?cctattttgt?ggaccttgtc?atacagaaac?cactccggat?acatcaccat?tcagtcccag

601?tcttcattcc?cctggaagag?atagctgcaa?aatatttaca?gaccaacatc?cagcacttcc

661?tgttcagtct?ctgcgagtac?ctgaatgctt?actctgggag?gaagtaccag?gcagaccggc

721?ttcagagtga?ctttgcagcc?ctcctgactg?ggcccttgca?gagaaaccca?ctgtgtaact

781?tgctgtcatt?tacttacaaa?ctggatccag?ggggtcagtc?cttcccgttc?tgtgctagat

841?tgctgtataa?ggacctcaca?gcaactcttc?ccactgacgt?caccgtgaca?tgtcaaggag

901?tggaagtatt?atccacttca?tgggaggagc?aacgagcatc?tcatgaaact?ctgttctgta

961?cgaagccctt?gcatcaagtg?tttgcctcat?ttacaagaaa?aggagaaaag?ttggatatga

1021?gtctggtctc?ctaatagatt?gttttcactg?cactgggagc?acatcagaga?aataaatccc

1081?ccctcccctg?ccaggtgaaa?ggaaatattg?cactttctgt?tctcatgact?aaggggacag

1141?gagttccaga?agaacctttc?aagatgatca?ggaacaccag?gacgagggcc?gtctcacctc

1201?actcggacca?catggagacc?tcccttcaaa?atgggagcca?tgtcctgccc?caccaagccc

1261?tgtctgaagt?ggagcttccc?cgcctgtgct?ccctccacag?tcccggaaag?cccagcggca

1321?aaggcagctt?tgtcccagct?ctgccaccct?cctgctcaca?gtggtcaggg?cccctcaggg

1381?gcaaggacgg?cagggattgg?aacgagggct?ctggaaggac?tgttcagccc?tatgcctaag

1441?acccctatgc?tggggacact?acaggcacac?agaggaatag?cagggccacc?ctcagagctc

1501?acacatccac?gaacaaatga?aggctgagga?ggtttctaaa?cctaaagtcc?atgagtgtgc

1561?acttcaatcc?aggaaggtcg?ggacttcctt?cagtttcaaa?aaataaattc?tcccttccgg

1621?tttggactgt?taaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaa

<210>6

<211>1501

<212>DNA

<213>Homo?sapiens

<400>6

1?cccaagcagg?tcggcggcgg?cggcaggaga?gcggccgggc?gtcagctcct?cgacccccgt

61?gtcgggctag?tccagcgagg?cggacgggcg?gcgtgggccc?atggccaggc?ccggcatgga

121?gcggtggcgc?gaccggctgg?cgctggtgac?gggggcctcg?gggggcatcg?gcgcggccgt

181?ggcccgggcc?ctggtccagc?agggactgaa?ggtggtgggc?tgcgcccgca?ctgtgggcaa

241?catcgaggag?ctggctgctg?aatgtaagag?tgcaggctac?cccgggactt?tgatccccta

301?cagatgtgac?ctatcaaatg?aagaggacat?cctctccatg?ttctcagcta?tccgttctca

361?gcacagcggt?gtagacatct?gcatcaacaa?tgctggcttg?gcccggcctg?acaccctgct

421?ctcaggcagc?accagtggtt?ggaaggacat?gttcaatgtg?aacgtgctgg?ccctcagcat

481?ctgcacacgg?gaagcctacc?agtccatgaa?ggagcggaat?gtggacgatg?ggcacatcat

541?taacatcaat?agcatgtctg?gccaccgagt?gttacccctg?tctgtgaccc?acttctatag

601?tgccaccaag?tatgccgtca?ctgcgctgac?agagggactg?aggcaagagc?ttcgggaggc

661?ccagacccac?atccgagcca?cgtgcatctc?tccaggtgtg?gtggagacac?aattcgcctt

721?caaactccac?gacaaggacc?ctgagaaggc?agctgccacc?tatgagcaaa?tgaagtgtct

781?caaacccgag?gatgtggccg?aggctgttat?ctacgtcctc?agcacccccg?cacacatcca

841?gattggagac?atccagatga?ggcccacgga?gcaggtgacc?tagtgactgt?gggagctcct

901?ccttccctcc?ccacccttca?tggcttgcct?cctgcctctg?gattttaggt?gttgatttct

961?ggatcacggg?ataccacttc?ctgtccacac?cccgaccagg?ggctagaaaa?tttgtttgag

1021?atttttatat?catcttgtca?aattgcttca?gttgtaaatg?tgaaaaatgg?gctggggaaa

1081?ggaggtggtg?tccctaattg?ttttacttgt?taacttgttc?ttgtgcccct?gggcacttgg

1141?cctttgtctg?ctctcagtgt?cttccctttg?acatgggaaa?ggagttgtgg?ccaaaatccc

1201?catcttcttg?cacctcaacg?tctgtggctc?agggctgggg?tggcagaggg?aggccttcac

1261?cttatatctg?tgttgttatc?cagggctcca?gacttcctcc?tctgcctgcc?ccactgcacc

1321?ctctccccct?tatctatctc?cttctcggct?ccccagccca?gtcttggctt?cttgtcccct

1381?cctggggtca?tccctccact?ctgactctga?ctatggcagc?agaacaccag?ggcctggccc

1441?agtggatttc?atggtgatca?ttaaaaaaga?aaaatcgcaa?ccaaaaaaaa?aaaaaaaaaa

1501?a

<210>7

<211>1694

<212>DNA

<213>Homo?sapiens

<400>7

1?caagtatttt?gcttcgatga?tttcacgtca?tcttcaaaac?aacctcatga?gggctgggtc

61?agttagaacc?taaacaaact?agagacctgg?ttgcaacccc?tcaggctctg?ctgatgctgt

121?ccccctttgt?tcctgcagcg?tggaccctgc?cagcagccag?gccatggagc?tctctgatgt

181?caccctcatt?gagggtgtgg?gtaatgaggt?gatggtggtg?gcaggtgtgg?tggtgctgat

241?tctagccttg?gtcctagctt?ggctctctac?ctacgtagca?gacagcggta?gcaaccagct

301?cctgggcgct?attgtgtcag?caggcgacac?atccgtcctc?cacctggggc?atgtggacca

361?cctggtggca?ggccaaggca?accccgagcc?aactgaactc?ccccatccat?cagaggcaaa

421?tacttccctg?gacaagaaag?ccagatgaaa?ctgatctacc?agggccgcct?gctacaagac

481?ccagcccgca?cactgcgttc?tctgaacatt?accgacaact?gtgtgattca?ctgccaccgc

541?tcacccccag?ggtcagctgt?tccaggcccc?tcagcctcct?tggccccctc?ggccactgag

601?ccacccagcc?ttggtgtcaa?tgtgggcagc?ctcatggtgc?ctgtctttgt?ggtgctgttg

661?ggtgtggtct?ggtacttccg?aatcaattac?cgccaattct?tcacagcacc?tgccactgtc

721?tccctggtgg?gagtcaccgt?cttcttcagc?ttcctagtat?ttgggatgta?tggacgataa

781?ggacatagga?agaaaatgaa?aggcatggtc?tttctccttt?atggcctccc?cacttttcct

841?ggccagagct?gggcccaagg?gccggggagg?gaggggtgga?aaggatgtga?tggaaatctc

901?ctccatagga?cacaggaggc?aagtatgcgg?cctccccttc?tcatccacag?gagtacagat

961?gtccctcccg?tgcgagcaca?actcaggtag?aaatgaggat?gtcatcttcc?ttcactttta

1021?gggtcctctg?aaggagttca?aagctgctgg?ccaagctcag?tggggagcct?gggctctgag

1081?attccctccc?acctgtggtt?ctgactcttc?ccagtgtcct?gcatgtctgc?ccccagcacc

1141?cagggctgcc?tgcaagggca?gctcagcatg?gccccagcac?aactccgtag?ggagcctgga

1201?gtatccttcc?atttctcagc?caaatactca?tcttttgaga?ctgaaatcac?actggcggga

1261?atgaagattg?tgccagcctt?ctcttatggg?cacctagccg?ccttcacctt?cttcctctac

1321?cccttagcag?gaatagggtg?tcctcccttc?tttcaaagca?ctttgcttgc?attttatttt

1381?atttttttaa?gagtccttca?tagagctcag?tcaggaaggg?gatggggcac?caagccaagc

1441?ccccagcatt?gggagcggcc?aggccacagc?tgctgctccc?gtagtcctca?ggctgtaagc

1501?aagagacagc?actggccctt?ggccagcgtc?ctaccctgcc?caactccaag?gactgggtat

1561?ggatcgctgg?gccctaggct?cttgcttctg?gggctattgg?agggtcagtg?tctgtgactg

1621?aataaagttc?cattttgtgg?tcctgcaaaa?aaaaaaataa?aaaaaaaaaa?aaaaaaaaaa

1681?aaaaaaaaaa?aaaa

<210>8

<211>2097

<212>DNA

<213>Homo?sapiens

<400>8

1?ggcgcgggtt?tggtggcgcg?tttcagcgaa?gtcgcacgtg?aaggatagca?gtggcctgag

61?aaagacccag?tcatggcagc?ctccagcatc?agttcaccat?ggggaaagca?tgtgttcaaa

121?gccattctga?tggtcctagt?ggcccttatc?ctcctccact?cagcattggc?ccagtcccgt

181?cgagactttg?caccaccagg?ccaacagaag?agagaagccc?cagttgatgt?cttgacccag

241?ataggtcgat?ctgtgcgagg?gacactggat?gcctggattg?ggccagagac?catgcacctg

301?gtgtcagagt?cttcgtccca?agtgttgtgg?gccatctcat?cagccatttc?tgtggccttc

361?tttgctctgt?ctgggatcgc?cgcacagctg?ctgaatgcct?tgggactagc?tggtgattac

421?ctcgcccagg?gcctgaagct?cagccctggc?caggtccaga?ccttcctgct?gtggggagca

481?ggggccctgg?tcgtctactg?gctgctgtct?ctgctcctcg?gcttggtctt?ggccttgctg

541?gggcggatcc?tgtggggcct?gaagcttgtc?atcttcctgg?ccggcttcgt?ggccctgatg

601?aggtcggtgc?ctgacccttc?cacccgggcc?ctgctactcc?tggccttgct?gatcctctac

661?gccctgctga?gccggctcac?tggctcccga?gcctctgggg?cccaactcga?ggccaaggtg

721?cgagggctgg?aacgccaggt?ggaggagctg?cgctggcgcc?agaggcgagc?ggccaagggg

781?gcccgcagtg?tggaggagga?gtgagccgga?tgccccacac?accgccagtg?tcataccaaa

841?gagctgagct?gcttcggggc?catgcagccc?tcctgccagc?cccctgccct?tttcttgccc

901?tgtctctgaa?ccttcagaac?attgatcctt?gccgcagccc?cactagccaa?gagaaacaga

961?gaaagaccat?tccccctgcc?tgtccttgcg?gccctgtctt?ctgaggttct?ctgtctgggg

1021?ttggctctct?taaccctttc?tctgctccca?gcctgcctca?ccagggaagg?ttggaggggc

1081?ctccctctgg?cttctgcatc?tgcgccagca?aacatcactg?ccgttggtct?ctcatgactt

1141?aactggcttc?cctctgctgc?tgccttggct?tcctcctaat?gctcgtgctc?tcctgtcctt

1201?ctgaagttgc?tccttggcca?aatctccagc?tcccttcttg?ttttcctcat?cctcctaccc

1261?tgtactccca?ccaaaccatg?gtcctttaag?gcacgctcct?gtcctcctca?ttgcccagca

1321?gtagggaggg?gcaggggtaa?ggggacctga?ggataaaggg?tggggaaaca?gggtcccctg

1381?aggcctgtgg?gggctgcagg?ggaggaggat?gtaccttgtg?tctctttcaa?gtgccttaat

1441?ccgagccagc?agggccttct?gcttgcctgc?tgccatactg?tatgtaggaa?agtgttctgt

1501?ggctgctttg?tgtcaaaaga?gcagtcactc?tcagaatctt?gattccccat?cagccaaagc

1561?aaaagatggc?tgctgctttg?taggcatgtg?cctgcaagtg?ggaccttgct?gggcattata

1621?tgccctgtgg?gggtttcaga?gaccctgaaa?gaggagggag?gacccgcctc?cttgtctgca

1681?caactgcatg?cacttctctc?cccatcgctc?cacaacctga?aaccgagaag?gagttgctga

1741?ccagtgccca?ccccggcagc?ccgggaggaa?cacaggcagc?tcctttccct?tcacgtggtc

1801?tgcagagagc?agggtgagct?gccagctgcc?cctctccacc?agggtaccct?gtcttggtgg

1861?ttaggggcca?cttttccttt?gaggctctag?tggaggtgga?tgtccttctc?tgccaggctt

1921?ggcacatgat?gtgaagaata?aatgcccaat?tcttactgtt?caggtttgat?gtggaatcac

1981?agctgcagtg?atatatattt?tttatcagtg?cttggttggt?tttaaataaa?gtgcacgcta

2041?ttttattatc?ttgttctgaa?taaaatgtat?ttactccaaa?aaaaaaaaaa?aaaaaaa

<210>9

<211>2416

<212>DNA

<213>Homo?sapiens

<400>9

1?ggagtgattg?cccggcagag?cgcgatactc?gtttgtagtt?tcataaacat?tgatgttggg

61?tcaatcatgt?tctcaatgta?tttaaccatg?tgtttttaaa?ttttttaatt?tagttatcaa

121?attgagaatc?tgatggtatg?gcattaatca?ccttgaggaa?gaacctttat?cgtttatctg

181?attttcagat?gcatagagct?ctggctgctt?taaaaaataa?acctctaaat?catgttcaca

241?aggtagtcaa?ggagcgtctg?tgcccttggt?tgtgttcacg?acaacctgag?cctttcgggg

301?tcaaattcca?tcatgcccat?tgtaaaaagt?ttcattcgaa?aaatggaaat?gaccttcatc

361?cactcggtgg?accagtgttc?tctcaagtat?ctgactgcga?caggcttgaa?caaaatgtta

421?aaaatgagga?gagtcagatg?ttttacagga?gactgagcaa?cttgacttca?tcagaagaag

481?tgctaagttt?tataagcacg?atggaaaccc?tgcctgacac?tatggcagca?ggagctttac

541?aacgaatttg?tgaagtggaa?aaaaaggatg?gtgatcaagg?gctgccaaaa?gaaatactgg

601?agaatagcat?ctttcaagct?ttatgctttc?agtttgaaaa?ggagccctca?cagctgtcaa

661?acactagttt?agtgactgct?ttgcaagctc?tgattctgtt?gcatgtggat?cctcaaagta

721?gcctgttgct?gaacctggtg?gcagaatgcc?aaaatcgtct?cagaaaaggt?ggcatggaag

781?ttcgcaatct?ttgtattctt?ggggaaagtc?tgattacact?gcacagttca?ggttgtgtga

841?cactagaact?cattataaat?caacttcaag?gtgaaaaatt?ggaaacattt?accccggagg

901?atattgtggc?cctttataga?atcttgcagg?catgtactga?aaaagtggat?gaacaccaaa

961?catttttaaa?taagataaac?aacttttccc?tatcaatagt?ttccaacctg?agtcctaaat

1021?tgattagcca?aatgctcact?gccctggtgg?ttcttgatca?aagtcaagca?tttcctctga

1081?ttataaaatt?gggcaaatat?gtcgtgaggc?atgtcccaca?tttcactaac?gaggagctta

1141?ggagagtctt?ggaggcgttc?atatattttg?ggcaccatga?cacatttttt?acaaaagccc

1201?tagagcatcg?tgtagctgcg?gtgtgcctca?cgttggatcc?tgaagttgtc?tgcagggtca

1261?tggagtactg?cagtagagaa?ctgattcttt?caaaacccat?cctcaatgca?gtggcagaaa

1321?cttttgtttg?ccaaacagaa?aaattttcac?ctcgtcagat?ttctgcgtta?atggaaccat

1381?ttgggaaact?caattatttg?ccaccaaatg?cctctgcttt?atttagaaag?ctggaaaacg

1441?tgctattcac?tcatttcaat?tattttccac?ccaaatcatt?attgaaactt?cttcattcat

1501?gttcacttaa?tgaatgccat?ccagtcaact?ttctggcaaa?aatattcaag?cctcttttcc

1561?ttcaacggct?gcaaggtaaa?gaatctcatt?tggacacatt?gagtcgggca?caactgaccc

1621?aacttttctt?agcctcagtc?ctggaatgcc?ctttctataa?gggtccaaaa?ctccttccta

1681?aatatcaagt?gaagtcattt?cttaccccat?gctgttccct?ggagacccct?gtggattctc

1741?agctttatag?atatgtgaag?attgggctga?ctaacctttt?aggagcaaga?ttatattttg

1801?ctccaaaagt?gttgacaccc?tattgttata?caatagatgt?tgaaattaaa?ttagatgaag

1861?aaggatttgt?attgccatcc?acagctaatg?aagatatcca?taaaaggata?gcactgtgta

1921?ttgatggtcc?aaaaaggttt?tgctccaata?gcaaacactt?actggggaaa?gaagctatta

1981?aacaaagaca?cctacagtta?ctcggttatc?aagttgttca?gatcccctat?catgagattg

2041?ggatgctaaa?atcaagacgt?gaattggtgg?aatatttaca?aagaaaactg?ttttctcaaa

2101?acactgttca?ttggttgcaa?gaatgaatac?tgacttcaga?actcaaacaa?tggaagaact

2161?tgcattttta?tggaactcag?tattaaaaga?aaaatataat?gtgaattagc?cactttgcag

2221?aatatgttct?agactggtga?tctgaaagca?tctgtagttt?tccttatact?atgtatacat

2281?ttattgtggt?aaaatttaaa?attaatttta?atttaatact?agtgtcatag?atactttttg

2341?tacatcaaac?aattgatcat?gtgctgtaaa?ggaattcaat?gaataaatgt?tatttttaag

2401?taaaaaaaaa?aaaaaa

<210>10

<211>1587

<212>DNA

<213>Homo?sapiens

<400>10

1?gggcagagga?ctgctgtttg?ctgacacaat?cttggtgcgt?tggaagtgaa?agggaagagg

61?cactggtggc?tgtgctttgg?gcccgagcag?ccagaagcca?gttgccatca?cctatgacga

121?ggagacagcg?cctggggcag?agcccagtat?ggggcctagc?cagggctggg?ttctcaccca

181?cctgtgccgc?cctgccttgt?tacctggaag?cacagccttg?gggactgagc?aggccctcac

241?tgtcacttta?agaagggaat?cagccacttt?gtgctcacca?cctctgggga?aggtgtgaga

301?ggagagaagg?aagtggctgt?ttggctgctg?acaacatgaa?gacttcctgc?gatgagaaca

361?gaggcacagg?tgccggccct?gcagccccca?gaacctggac?tggagggggc?catggggcac

421?cggaccctgg?tcctgccctg?ggtgctgctg?accttgtgtg?tcactgcggg?gaccccggag

481?gtgtgggttc?aagttcggat?ggaggccacc?gagctctcgt?ccttcaccat?ccgttgtggg

541?ttcctggggt?ctggctccat?ctccctggtg?actgtgagct?gggggggccc?caacggtgct

601?ggggggacca?cgctggctgt?gttgcaccca?gaacgtggca?tccggcaatg?ggcccctgct

661?cgccaggccc?gctgggaaac?ccagagcagc?atctctctca?tcctggaagg?ctctggggcc

721?agcagcccct?gcgccaacac?caccttctgc?tgcaagtttg?cgtccttccc?tgagggctcc

781?tgggaggcct?gtgggagcct?cccgcccagc?tcagacccag?ggctctctgc?cccgccgact

841?cctgccccca?ttctgcgggc?agacctggcc?gggatcttgg?gggtctcagg?agtcctcctc

901?tttggctgtg?tctacctcct?tcatctgctg?cgccgacata?agcaccgccc?tgcccctagg

961?ctccagccgt?cccgcaccag?cccccaggca?ccgagagcac?gagcatgggc?accaagccag

1021?gcctcccagg?ctgctcttca?cgtcccttat?gccactatca?acaccagctg?ccgcccagct

1081?actttggaca?cagctcaccc?ccatgggggg?ccgtcctggt?gggcgtcact?ccccacccac

1141?gctgcacacc?ggccccaggg?ccctgccgcc?tgggcctcca?cacccatccc?tgcacgtggc

1201?agctttgtct?ctgttgagaa?tggactctac?gctcaggcag?gggagaggcc?tcctcacact

1261?ggtcccggcc?tcactctttt?ccctgaccct?cgggggccca?gggccatgga?aggaccctta

1321?ggagttcgat?gagagagacc?atgaggccac?tgggctttcc?ccctcccagg?cctcctgggt

1381?gtcaccccct?tactttaatt?cttgggcctc?caataagtgt?cccataggtg?tctggccagg

1441?cccacctgct?gcggatgtgg?tctctgtgtg?tgcgtgtgtg?ggcacaggtg?tgagtgtgtg

1501?agtgacagtt?accccatttc?agtcatttcc?tgctgcaact?aagtcagcaa?cacagtttct

1561?ctgatgtcga?aaaaaaaaaa?aaaaaaa

<210>11

<211>1498

<212>DNA

<213>Homo?sapiens

<400>11

1?cagagtttgg?gcgccaggcg?agacggcagg?gcttaaagtt?ccgggaatca?aagatcaact

61?cccactgagg?acaaatggac?ctgtaattcc?gggtgtgacg?agagaacgag?atttaccttc

121?ctgaattaaa?aaacaggtca?ttaagcttgg?gccctgactt?ttctttgtga?gaaggtacag

181?agatggaaac?cttacaatcc?gagactaaaa?cgagggtcct?tccctcatgg?ctgacagccc

241?aggtggctac?aaagaatgtg?gcaccaatga?aggcccccaa?gaggatgaga?atggcagcag

301?tgccagtggc?agcagcaaga?ctccctgcga?caaggactgt?gtactgcatg?aatgaggctg

361?agatagttga?tgttgctctg?ggaatcctga?ttgagagccg?caaacaggaa?aaggcctgcg

421?agcagccggc?cctggcgggg?gctgataacc?cagagcactc?ccctccctgc?tccgtgtcgc

481?ctcacacaag?ttctgggagc?agcagtgagg?aagaggacag?tgggaaacag?gcactggctc

541?caggcctcag?cccttcccag?aggccggggg?gttccagctc?tgcctgtagc?aggagccctg

601?aggaggagga?ggaagaggat?gtgctgaaat?acgtccggga?gatctttttc?agctagggca

661?taaactgtgc?actgaactgt?ctgccgagag?cagctggagg?acagctgagc?ttccactggt

721?gctgctgggc?cgcccgcctg?tgggaatggg?gctctctgtg?ctcctacctt?tgtgccttct

781?tgggcctggc?agattcacct?caggccagaa?gcccctggac?actccgggcc?ttggggctgc

841?cgttctgagt?gtgcggaagg?caggactcaa?aatgagatcc?catttgactc?cctctgtatg

901?tactgtgccc?tctcctggct?cttgaggctc?tggagtccca?attgtctgtg?ttagtcagtg

961?accaggttcc?agggaaaatg?atgtcatgtg?gtggtccaac?ttactggaac?caaagagaca

1021?gtactttgca?aagaaaagga?tcactgccag?gtgcactgga?attgctacag?tttagtccgc

1081?atgatctctc?ctgaaggagg?aagcctgttt?caaaaatagt?ttccatcatg?agtctatcaa

1141?tgagctccca?cctctccagc?cagcctagaa?agcaaacgag?ctgcccacag?ttctctgccc

1201?tgtctgggag?gttgaggcca?cagtgtatag?actggtaagc?cagacaggcc?tcctcccgca

1261?agctgctacc?ttgctttcac?ctgtaccttg?gtccccgggc?agctagctat?aaagcaagag

1321?ggacaggagc?ccagaagaga?cactgaggac?aagagatcac?accagagtac?atgtctctgc

1381?ctctgttttc?agtgtggctt?tggacaggaa?tatatgaata?aatcactgcc?atacaggttt

1441?tccaatacac?aagtgctaga?aaatacacac?aattccccaa?tgaaaaaaaa?aaaaaaaa

<210>12

<211>1534

<212>DNA

<213>Homo?sapiens

<400>12

1?tcagtgggcg?tcgcgcgaag?gctaagggag?tgtggcgggc?ggctccggga?gccaacatgc

61?ctcggtatgc?gcagctggtc?atgggccccg?cgggcagcgg?gaagagcacc?tactgtgcca

121?ccatggtcca?gcactgtgaa?gccctcaacc?ggtctgtcca?agttgtaaac?ctggatccag

181?cagcagaaca?cttcaactac?tccgtgatgg?ctgacatccg?ggaactgatc?gaggtggatg

241?atgtaatgga?ggatgattct?ctgcgattcg?gtcccaacgg?aggattggta?ttttgcatgg

301?agtactttgc?caataatttt?gactggctgg?agaactgtct?tggccatgta?gaggacgact

361?atatcctttt?tgattgtcca?ggtcagattg?agttgtacac?tcacctgcct?gtgatgaaac

421?agctggtcca?gcagctcgag?cagtgggagt?tccgagtctg?tggagttttt?cttgttgatt

481?ctcagttcat?ggtggagtca?ttcaagttta?tttctggcat?cttggcagcc?ctgagtgcca

541?tgatctctct?agaaattccg?caagtcaaca?tcatgacaaa?aatggatctg?ctgagtaaaa

601?aagcaaaaaa?ggaaattgag?aaatttttag?atccagacat?gtattcttta?ttagaagatt

661?ctacaagtga?cttaagaagc?aaaaaattca?agaaactgac?taaagctata?tgtggactga

721?ttgatgacta?cagcatggtt?cgatttttac?cttacgatca?gtcagatgaa?gaaagcatga

781?acattgcatt?gcagcatatt?gattttgcca?ttcaatatgg?agaagaccta?gaatttaaag

841?aaccaaagga?acgtgaagat?gagtcttcct?ctatgtttga?cgaatatttt?caagaatgcc

901?aggatgaatg?aagagtttac?taaaagtaac?catctaaaga?gcttgtggcc?aaaccagcag

961?aacattcttc?tcttcaaagg?atgcaatagt?agaaagctac?ttattttaat?gaaaaaaagt

1021?aaaacttcgt?tctttatcag?cctcatgcct?gaatcaaatt?tttaattatt?ctgaaactgc

1081?tgctgtttaa?agtggaatct?tttagtatta?taacagcatc?actttagatt?ttgtaagtca

1141?aaattgaaat?gaatgcacat?agatttatat?ataaattagc?acctgagcta?aggttaaggc

1201?tggtctaaac?ttattttcac?tttttgtatt?atttttgaga?tgcaggaatt?actgtaacaa

1261?aatatgtatg?tccgaaggga?aaaagctgca?aggatatata?taagaccact?gcttatctgt

1321?atcttcccat?tttcctatat?tgaaaatgta?tattatttat?ataacttaaa?aagtaaaaat

1381?aactatgttt?tgagatatgt?atgtgtatat?ataaaagaaa?caaaggtttt?taatgattct

1441?tggacctaga?taacaagtaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa

1501?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaa

<210>13

<211>1624

<212>DNA

<213>Homo?sapiens

<400>13

1?gagggatgca?ggccagccag?ggatccagcg?tcttccccat?cgtcactctc?catggcctcc

61?gtctacacac?agtgttcgtc?tgcacagctt?gtcagcgcgt?tatcatgact?tctatttggc

121?accggcccgt?ctgtccactg?tcctggcttg?ttccaagcgc?tgccttctcc?aactggggtc

181?ctggctgcag?agctgtctgc?tccccacgtt?gggcaactcc?agccaagatt?cctacaccca

241?aatgtgaccg?tgttgctcac?gaagaaggct?cagctttgcg?tgtgcccagc?cgtgtgcaca

301?gctcgtccca?actcctgcgg?gtggcacctg?cctctcccac?ctccagtctt?tcccctgtga

361?tgagcagatg?accaccgccc?tccagggtca?gcgtttggct?gtttgtgtgc?ctgcccaccc

421?gcctccctgt?gcctgggcct?gccctgtgcc?tgcacacagg?agtggctcat?ggcgtttgcc

481?ctacacggat?gggctgtcct?gggagctact?ggacagtcac?cttggtggga?atgccagagg

541?catgggcatt?aggtcccccc?ggccagcctc?cgttgccaca?tgggctattt?ttgtccatcg

601?cgtgggacaa?cctagtattg?ggggaaaact?cagtccactc?taaagaagca?tcggcgtttt

661?ggatggacga?atgctgcttc?atgcgtctcc?atgtcaatgg?actattttat?tcaactcggg

721?tatttatgag?tgtctcctct?gtgccagcca?cgtgtgaaag?aagaactcca?agttactgga

781?caccaggaca?aaccaggtag?atcactgcat?ccggttcctc?ctctttctgc?cgactctccc

841?gggcaaccgt?tctgattcct?ggcatggagt?tgggggcgag?ctcatcagta?cccagagcgc

901?ctggtgtgca?gccaaaggcc?cccattttat?tagtcggtgt?gttcagtatc?acgctcaaga

961?caagggccaa?cctattactt?cacacacctc?aaatacaaaa?agtgcctggg?aacgtcgatg

1021?aggtattaaa?ggaaaccact?ggtcttgtca?gtcatgtaca?cacagaaaaa?aaaaccagtc

1081?atttttattt?ttattttttg?agacagagtt?tcgctcttgt?tgcccaggct?ggagtgcaat

1141?ggtgcaattt?cagctcactg?caatctctgc?cacccggatt?caagcaattc?tcctgtctca

1201?gcctcccgag?tagctggaat?tgcagacacc?catcaccacg?cccagctaat?tttatgtatt

1261?tttagtagag?atggggtttc?accatgttgg?tcaggctggt?cttgaactcc?tgacctcagg

1321?tgatccaccc?acgtcaggct?cccaaagtgc?tgagattaca?ggcatgaacc?actgtgccca

1381?gccgaaaaca?accaagaatt?ttttaacaat?aaaatgacca?gcaagtaaac?ttgaaacaaa

1441?aatggacaaa?tatctaaaat?atttttaaat?gtatgtattt?taattggcaa?ataatacttg

1501?tatatattgt?ttacaacttg?ttttaaagta?tgaatacatt?gtgaaaaaaa?aaaaaaaaaa

1561?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa

1621?aaaa

<210>14

<211>1962

<212>DNA

<213>Homo?sapiens

<400>14

1?gtggctcata?agtgtctcta?agttatacca?aaagtttgag?cacaacagta?gtagcagaat

61?gcttagaata?aatgcttgac?ttttaagctg?acttttggaa?ggaccatacc?cacatagagg

121?catcttttct?gctgtggtaa?ttttttaaat?taatacattg?ctttaggatt?acatctcaaa

181?gtaaataaaa?aaatcaatat?ttaatttgtt?tttttcctgc?aaataaatta?aatgctggga

241?ccataatgat?tatttttgca?tagtaatagc?tggtgaagaa?gttgttttaa?aattaaattg

301?ccaaaagtat?tacctcttga?aaaatttatt?ttcccaaagt?ttttcatatg?tcatgaaacc

361?cctaatcttg?acctttatga?cacagtggca?ttacactgat?gttggaagca?tgtgtgagat

421?ctgtgccctg?gtcgggagtc?atatgcctta?aaaatgactg?cgagtcagtg?tgaagtagta

481?taaagtggag?tcctacgtgg?gaaaaagcag?gctactgagg?acaaaaacct?cccaaccctc

541?cccaccttgt?tttccactgg?gaatgagaat?ttgatatgag?aaacttcaac?cttgcagaag

601?tgtggatttc?cctctgaaat?ttaaatgttt?cacacatttt?tgtacctttt?gtaaccttgt

661?ggtatttact?ttcacatggc?tttttaaaaa?attattttaa?tgaacttcta?tcacactata

721?tgaatgatat?gggggaaata?ctgaactgct?catatttcct?tttttggcaa?taaagcactg

781?ttatatgtaa?atgtaagtga?aaaagaggtt?caagactata?caacagctta?tgtgtagtat

841?atgttgacat?ccctaaggta?ttttgaaaca?tgaggtgaca?gacaaggacc?tcaaatttcc

901?agggaaatat?ttatttcaca?acattaggag?tgtagctctt?cataatgaaa?tatcttcttt

961?ctgctaaaga?ttacaatttt?tcatttaggg?aactgtgaat?attttctgtg?aggtttacag

1021?aaactagtgt?atccttttca?ctatgttgaa?aagacaatct?gaactttagc?tatttatatt

1081?tcagtattaa?cacaccttca?ctgattgaga?gtcttgagcc?cttctctact?tttataaagt

1141?gaatcctatt?tccaagtcat?ccatgtcttt?tgaagtctgt?ttcttatata?agtatttatt

1201?actttactgt?ttagcataaa?taggagacag?aaaaggataa?taaactacta?ggtcctttat

1261?tcctattaaa?ataaatttat?aaatcccttg?aatcaactga?attctaagct?ttttgaagag

1321?gttgctgatg?tagtgtgatc?aaaagaatct?aaggagaacc?tcatctccaa?aatctgattg

1381?gagctgttca?ccctctcaag?gacaagataa?agattgactt?cagagatata?tcacatcaag

1441?ctagaggaaa?aaaaaaaaac?ctcaaataaa?atttttcctc?attcgaaggg?atccagggta

1501?tccttgggtt?atgtaggagg?gaatcatatt?tgttctaatt?tacctgaatg?tacttgtgtg

1561?tgaatccaat?cttgattcta?aacaccaaat?cttgtcaaca?gtagagaagt?atagtaagga

1621?gttcctgttg?tcaatcaaat?gagggtgtga?aacatttaga?atgctctgtg?ttacacttga

1681?accatgtata?aatgtaacct?gtgtatcttt?tttttaatta?gcttttctga?atttaaatta

1741?tattgttttt?ctttgtattg?ttagcaaaat?gcatcagaac?tggatttttt?ttctcatctg

1801?aacataatat?aaaatttgaa?agagtattgt?gatattaagc?actttaacat?acatatcaga

1861?caaactgacg?tgggtttttc?aggtttggga?gtacatttaa?atatgacttt?tcatgctttg

1921?ttctttacaa?ataaaactgt?gggattgata?aaaaaaaaaa?aa

<210>15

<211>1849

<212>DNA

<213>Homo?sapiens

<400>15

1?gcacagtatc?tgggtccagc?ctgcagccct?agggtccagt?tcagagtctg?tcatctgaac

61?catgaggatc?tggtggcttc?tgcttgccat?tgaaatctgc?acagggaaca?taaactcaca

121?ggacacctgc?aggcaagggc?accctggaat?ccctgggaac?cccggtcaca?atggtctgcc

181?tggaagagat?ggacgagacg?gagcgaaggg?tgacaaaggc?gatgcaggag?aaccaggacg

241?tcctggcagc?ccggggaagg?atgggacgag?tggagagaag?ggagaacgag?gagcagatgg

301?aaaagttgaa?gcaaaaggca?tcaaaggtga?tcaaggctca?agaggatccc?caggaaaaca

361?tggccccaag?gggcttgcag?ggcccatggg?agagaaaggc?ctccgaggag?agactgggcc

421?tcaggggcag?aaggggaata?agggtgacgt?gggtcccact?ggtcctgagg?ggccaagggg

481?caacattggg?cctttgggcc?caactggttt?accgggcccc?atgggcccta?ttggaaagcc

541?tggtcccaag?ggagaagctg?gacccacggg?gccccagggt?gagccaggag?tccggggaat

601?aagaggctgg?aaaggagatc?gaggagagaa?agggaaaatc?ggtgagactc?tagtcttgcc

661?aaaaagtgct?ttcactgtgg?ggctcacggt?gctgagcaag?tttccttctt?cagatgtgcc

721?cattaaattt?gataagatcc?tgtataacga?attcaaccat?tatgatacag?cagcggggaa

781?attcacgtgc?cacattgctg?gggtctatta?cttcacctac?cacatcactg?ttttctccag

841?gaatgttcag?gtgtctttgg?tcaaaaatgg?agtaaaaata?ctgcacacca?aagatgctta

901?catgagctct?gaggaccagg?cctctggcgg?cattgtcctg?cagctgaagc?tcggggatga

961?ggtgtggctg?caggtgacag?gaggagagag?gttcaatggc?ttgtttgctg?atgaggacga

1021?tgacacaact?ttcacagggt?tccttctgtt?cagcagcccg?tgacagagga?gagtttaaaa

1081?atccgccaca?ccatccatca?gaatcagctt?gggatgaact?tattcagatg?gttttacttt

1141?attaattcct?ccaattatta?caataatcat?aaaaaggtga?aaatggaaaa?gttattccca

1201?aaactgattc?tgtgtaactt?actatttttc?caggagtaaa?tatttaaaat?agctgcatgg

1261?tttattctaa?tttatttcac?atttcttatt?cctattatct?gaagaatccc?tcgtctgtgc

1321?gtttcttgtg?ggaagagtgt?tttaatatca?ttttagtgct?ctgaggagtc?atatgaagat

1381?gtatccctca?tctgtgtttc?tgaggacatt?aaggggaaat?tagagggaaa?tgtttattca

1441?atttagtact?agcaacagct?ttaagctggt?gatgctgtca?tactccagaa?agctgtagac

1501?actgctcatt?ttgtctttta?aaaaaatttt?attttatttt?aagttctggg?atacatatgc

1561?aaaacatgca?tgtttgttac?ataggtaaac?atgtgctgtg?gtggtttgct?gtatctatca

1621?acccatcacc?taggtattaa?gccctgcatg?cattagctat?ttgtcctggt?gctctccctc

1681?ccactttgct?cattttctaa?cctaggtttt?aatcaccatt?ttacccaaca?aatcattgtt

1741?cgatcattat?ttgccagact?tgaatctcta?tgtgttttct?aggactgctc?taataaagta

1801?cacaaactgg?gagtctttaa?acaacaaaaa?aaaaaaaaaa?aaaaaaaaa

<210>16

<211>1870

<212>DNA

<213>Homo?sapiens

<400>16

1?agtctagtgg?gataccaggc?cctgagagac?ccctacgatc?ccaggacact?gatgtggggt

61?aactaacacc?cactggaagt?ctacgctgag?ttcacaggct?atgtatgacc?tgacatgcat

121?tttgacctgc?cctgtgtttt?gatatttgaa?tgagttgctg?atgtttacaa?gccgaagctg

181?gccgggcgtg?gtggctcgcg?cctgtaatcc?cagcactttg?ggaggtcgag?gcaggaggat

241?cgcttcaggt?caggagttcc?agaccagtct?ggccaacatg?gcgaaacctc?gtctctacta

301?aaaaaaaaaa?aaaaaaaaat?acaaaaatta?gccgggcgtg?gtggcacgcc?cctgtaatcc

361?caggactcgg?gaggctgaga?caattataaa?ttcattaacc?cccagaactc?ttggctagac

421?ttcataaagg?caaaaactgt?gtttgccctg?ttaactgctt?tatcccacca?ctagaatata

481?agcttcctga?agacagaaga?cttctgttat?tttgttcaca?gttaccaagc?atgcctactt

541?tgttaaattt?atgaaagaac?tttaaagagt?cagaggttcc?ggttgagatc?aagttgggag

601?acacaccctt?gttcattctc?cttgagaagc?agctattatc?aacagaacat?tgacggaacc

661?tgtgtttggg?gaaaggactg?atggctttga?gtctaggttg?gaaagcacac?aggaaccact

721?gtggtctcct?cttgcaggct?ctgcgaagca?gtggtcttct?cttgtttccc?tgtggccagt

781?gtccctggag?aggagctgga?agctttttgg?accctgagat?aaaggctttc?ctggaggaga

841?acactgaagt?caccagcagt?ggtagcctca?cccctgaaat?ccagttgcgg?cttttgaccc

901?ccagatgcaa?attctggtgg?gagagagctg?acctgtggcc?ccacagtgat?ccttactggg

961?caatctactg?gccaggaggc?caagccctgt?ctaggtatct?tttggataat?cctgatgttg

1021?tcagaggaaa?atctgtatta?gatcttggga?gtggatgtgg?agctacagct?attgctgcta

1081?agatgagtgg?ggcatcaagg?atcttggcca?atgacataga?ccctattgca?ggaatggcta

1141?ttacactaaa?ttgtgaattg?aacagactga?atccttttcc?tattttaatc?caaaacattt

1201?tgaatttgga?acaagataag?tgggaccttg?ttgttcttgg?cgatatgttt?tatgatgaag

1261?accttgcaga?tagtcttcat?cagtggctga?agaagtgctt?ctggacctat?agaactcgag

1321?tactgattgg?tgaccctggg?cggccccagt?tcagtggaca?cagcattcag?catcacctgc

1381?acaaagtggt?agaatattca?cttttggagt?ctactaggca?ggaaaacagt?ggactgacaa

1441?caagcacagt?gtggggtttt?cagccttgag?ttgtcaaagt?gcttccaagt?atgaatatag

1501?taatgtttgg?atctgactct?aaaagttttc?tctataggag?atactctcca?gtttaatgaa

1561?tgtaattctt?gttaaatgga?aaatcttgtt?tttaaaatat?gaaggtttag?agttttgttt

1621?acttttgtca?tgtaactggt?tctgtatttc?tatgcatgcc?aattatacac?atctctatct

1681?gcattttttt?ttctatttta?accgctgaag?gaatatgatt?atacaatgcc?atactcaatg

1741?gtggcagcat?ttaatttaag?taatggagaa?gaattaaaca?ttgtagctgg?atctgtttct

1801?gtagtcgagg?acaactgtga?tgtaactttg?aattaaacaa?acaaaacaaa?acagaaaaaa

1861?aaaaaaaaaa

<210>17

<211>2145

<212>DNA

<213>Homo?sapiens

<400>17

1?caggccaccg?cggcctgtga?cgcgcacctc?ggcgcccaag?gcccgtagcc?gcgcagtttc

61?ctcgggcgtc?aggccgccgc?gcagcccggc?cgtatacacg?ggccccacgg?gctcgcagag

121?caggagcgcg?cccgcctcag?tccccgacgg?ggcctcaatg?cctggctcgg?cctgcagccg

181?ccgcagccag?cggtcctgca?gccccagtag?ctcggcgtac?ggcacccgac?ccaggcgcac

241?cagccgaacg?gcgggttgcc?gcatcgtgcc?caccgttgcg?tccgcggggc?cccgccctct

301?ccgtgggcct?gggggcgtgg?cctgaggggc?ggggactcgg?gggcacaccc?cgagccgcag

361?ctcccaggtg?cgtgttaaaa?gctggagggg?ggatatgtga?tcccaggacc?aaaagcgcgg

421?ggccagactc?atcggttcat?tcaacaacca?gtatttagtg?cctgctgtgt?tctgcaggcc

481?ctgccatagg?cgcttgatac?agcggtgcat?agcgtatgag?aaagatctgt?cctggctgag

541?catccgtaat?ataaaaatct?gaaatctgaa?atgctccaaa?atcctaaact?ttttgagtgc

601?tgacattatg?ccacaaatgg?aaaatttcat?acctgacctt?atgtgagttg?cagtcaaaac

661?acaggtgcac?aacacccagt?tcatgcaaca?tccccaatgg?gaaaaaagac?ccccccagct

721?ctcttctgct?gcagtttttc?tgctcacacc?tggatttccc?catgcattcc?cacaaaaagt

781?aattaaatgg?catgcgtgca?ggctggacac?gccaacaaca?ggtttcccac?aatgccccac

841?atggggccaa?gacctgtgtg?cattactcac?tgcatttttt?tgcttattct?ctgctgtgtg

901?gtataaatat?attgttgaaa?atgtcaaaaa?gacctaaaga?tacccctgtg?aatatcagtg

961?ataagaaaaa?gaggaagcat?ttatgtttat?ctatagcaca?gaaagtcaag?ttgttggaga

1021?aactggacag?tggtgtaagt?gtgaaacatc?ttacggaaga?gtatggtgtt?ggaatgacca

1081?ccatatatga?cctgaagaaa?cagaaggata?aactgttgaa?gttttatgct?gaaagtgatg

1141?agcagatatt?aatgaaaaat?agaaaaacac?ttcataaagc?taaaaatgaa?gatcttgatc

1201?gtgtattgaa?agagtggatc?cgtcagcgtc?gcagtgaaca?catgccactt?aatggtatgc

1261?tgatcatgaa?acaagcaaag?atatatcaca?atgaactaaa?aattgagggg?aactgtgaat

1321?attcaacagg?ctggttgcag?aaatttaaga?aaagacatgg?cattaaattt?ttaaagactt

1381?gtggcaataa?agcatctgct?ggtcatgaag?caacagagaa?gtttactggc?aagttcagta

1441?atgatgatga?acaagatggt?aactttgaag?gattcagtat?gtcaagtgag?aaaaaaataa

1501?tgtctgacct?ccttacatat?acaaaaaata?tacatccaga?gactgtcagt?aagctggaag

1561?aagaggatat?caaagatgtt?tttaacagta?ataatgaggc?tccagttgtt?cattcattgt

1621?ccaatggtga?agtaacaaaa?atggttctga?atcaagatga?tcatgatgat?aatgataatg

1681?aagatgatgt?taacactgca?gaaaaagtgc?ctatagacga?catggtaaaa?atgtgtgatg

1741?ggcttattaa?aggactagag?cagcatgcat?tcataacaga?gcaagaaatc?atgtcagttt

1801?ataaaatcaa?agagagactt?ctaagacaaa?aagcatcatt?aatgaggcag?atgactctga

1861?aagaaacatt?taaaaaagcc?atccagagga?atgcttcttc?ctctctacag?gacccacttc

1921?ttggtccctc?aactgcttct?gatgcttctt?ctcacctaaa?aataaaataa?aatacagtgt

1981?acagtaacct?tttagtcaaa?acagcatcat?acttggaaac?tgaaagccta?ctgttatttg

2041?ttattgttgc?ttaacagctg?atacagatat?tctggtgaca?ctactgtgct?ggcttactta

2101?acctgaatac?actatttttt?tcgttgtaaa?aaaaaaaaaa?aaaaa

<210>18

<211>1501

<212>DNA

<213>Homo?sapiens

<400>18

1?ctgggggggt?ttgttgggct?ggtgagtttt?cgaggtgact?gtgctgtgct?cggtgagggg

61?acgcccagag?agccctgacc?cggggtcact?ccgtcgccgt?tctcctcttg?tctacgtgct

121?ggacccggtg?ctaccttttt?acccacactt?aagtgacgca?aaatgccctt?caatggcgag

181?aagcagtgtg?tgggagagga?ccagccaagc?gattctgatt?cttcccggtt?ttccgaaagc

241?atggcttcgc?tcagtgacta?tgaatgctcc?aggcagagct?ttacaagtga?ctcctccagc

301?aaatccagct?ctcctgcttc?aacaagccct?ccaagggttg?taacatttga?tgaagtgatg

361?gctacagcaa?ggaacttatc?aaacttgact?cttgctcatg?agattgctgt?aaatgagaac

421?tttcaattga?aacaagaggc?tctcccagaa?aagagtttgg?ctggttgagt?gaagcacatt

481?gttcaccagg?ccttctggga?cgtcttggat?tcagaactaa?atgctgaccc?tcctgagttt

541?gaacatgcca?tcaaactgtt?tgaagaaatc?agagagattc?ttctctcttt?tctcactccc

601?ggtggcaacc?ggcttcgcaa?ccaaatctgt?gaagttttgg?acacagacct?cattaggcag

661?caggctgagc?acagtgctgt?tgacatccaa?ggcctggcca?actatgtcat?cagtacgatg

721?ggaaagctgt?gtgctcccgt?gcgagataat?gatatcagag?agttaaaggc?tactggcaac

781?atcgtggagg?tgctgagaca?aatattccat?gtcctggacc?tcatgcaaat?ggacatggcc

841?aattttacaa?ttatgagtct?cagaccgcac?cttcaacgcc?agttggtgga?atatgagaga

901?accaagttcc?aggaaatttt?ggaagaaact?ccaagaaaag?ccgaggttgc?aggtgcctca

961?tgaggctgac?cttgcttttg?gaaccagaga?gagcagtcac?cgtgccagcc?tgtgagagtg

1021?aagtctctgc?cgatccctaa?gagaagagcc?aacgtttcac?tctaaacgca?tgctccttct

1081?gctttaccgg?tcattctcaa?gtctgactac?aaattagaat?catctggggc?gtttaaacac

1141?agaggcctga?gccctgcctc?agacagaata?aatcaaagtc?tccaggagct?gtgcccatga

1201?actctttttt?tcctttttaa?agctccccag?gtgattctaa?agtcagccag?gattgagaac

1261?cactatgcca?cactgttgct?tttgttcaag?gtaactaaat?gggctcttaa?atgtgtcagc

1321?tgtaaatgat?taaacttgca?gtataaatgc?ttattactgc?cacattgtaa?ttatattcac

1381?gatgatttcc?actcgcgctc?tctcagttgg?atgtctttta?aatgaaagac?tgcaagtctt

1441?ttacatcttt?ataaaacaga?actagcaaac?caaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa

1501?a

<210>19

<211>1434

<212>DNA

<213>Homo?sapiens

<400>19

1?acgcacgcaa?gcggctccag?ggtacgtccc?cgccacgcgc?gctcgcagga?tcggtgcgtg

61?gtgacgtttc?gccggcgcgg?gcgccatccc?ggaagcgcga?gcaaggccgc?cagatgtgca

121?ggcagcggag?gaggagaaag?agatggacct?cccggactcg?gcctcgaggg?tcttctgcgg

181?ccgcatcctg?agcatggtga?acacagatga?tgtcaacgcc?atcatcctgg?cccagaagaa

241?catgctggac?cgctttgaga?agaccaatga?gatgctgctc?aacttcaaca?acctgtccag

301?tgcccgcctg?cagcagatga?gcgaacgctt?cctgcaccac?acgaggaccc?tagtagagat

361?gaaacgggac?ctggacagca?tcttccgccg?tatcaggacg?ctgaaaggga?aactggccag

421?gcagcaccca?gaggccttca?gccatatccc?agaggcatcc?ttcctggagg?aagaggatga

481?agaccccatc?ccacccagca?ccacgaccac?cattgccacc?tcagaacaga?gcacgggctc

541?atgtgacacc?agccccgaca?ccgtctcgcc?ctccctgagc?cccggcttcg?aggacctgtc

601?ccatgtccag?gctggctccc?cagccatcaa?cggccgcagc?cagacagatg?acgaggagat

661?gacgggcgaa?tagccctgct?gcccggtgcc?ttgagggggt?ctcagggcag?cagcatacaa

721?ggtggcagcg?ggtaaccctg?ccttgttctg?tcatccaggg?ctcctttgct?gccccgttct

781?gtcacccagg?gctcctaggg?ggacaaggct?ctctcccgag?gggtgtggaa?ttcctggggg

841?ggtctttaat?tctggctcct?tccttcctca?gaacatctct?attctgcaag?acccctctgc

901?catgccaggg?cacgcccatt?ccagctggag?tcgtggggct?gggcacaggg?gaatttttcc

961?agagctgagc?ctgacgtctg?ctctgaagaa?tgcttagaag?gttcccagac?accagagcca

1021?gatgtccccc?accaccggtc?aggacctcct?tgaggtgcac?aagcacggtc?tcctctgagt

1081?tcaccccagc?ccacccccgc?acccactaat?tctgcttttc?ctgccccttg?ctccgtaaaa

1141?gtatcaaata?ctttctcctt?ggtatctcaa?ggaggtttct?gagataggta?gaagtcttga

1201?gacggaggct?ggccatccat?tcagccctga?gcgtgctgag?ttctgtgttt?ctctgaatag

1261?aggtgtggaa?cctgaggggc?cagcaggcct?ctctgaaggc?ctccatggag?caaacggagc

1321?cacctcggga?aagagtttaa?tggaatattt?ttgtacccga?tgtttacaga?tgctgttggg

1381?aagttatcaa?taaaaagaca?ccattactaa?aaagggaaaa?aaaaaaaaaa?aaaa

<210>20

<211>1226

<212>DNA

<213>Homo?sapiens

<400>20

1?gtcatcgccg?cggggcggag?gcgacagtgt?ctagcgggag?ctccgcgtgt?agctacgccg

61?gccgcctggc?tttgagacaa?cgtgattctc?cgcagctggt?cgcctacccg?tgatgttctg

121?cccacgtcga?gacctgagct?gaaatggcag?acgatctcgg?agacgagtgg?tgggagaacc

181?agccgactgg?agcaggcagc?agcccagaag?catcagatgg?tgaaggagaa?ggagacacag

241?aagtgatgca?gcaggagaca?gttccagttc?ctgtaccttc?agagaaaacc?aaacagccta

301?aagaatgttt?tttgatacaa?ccaaaggaaa?gaaaagagaa?taccaccaag?accaggaaaa

361?gaagaaagaa?gaaaattact?gatgttcttg?caaaatcaga?accaaaacca?gggttacctg

421?aagacctaca?gaagctgatg?aaggactatt?atagcagcag?acgcttggtg?attgaattag

481?aagaactgaa?cctgccagac?tcctgtttcc?tcaaggccaa?tgatttgact?cacagtcttt

541?cctcatacct?aaaaggaatt?tgtcctaagt?gggtaaaact?taggaagaac?cacagtgaga

601?agaaatcggt?cctgatgctg?atcatctgca?gctcggccgt?ccgagccctg?gagctcatta

661?ggtcgatgac?agcattcaga?ggagacggca?aagttataaa?attatttgca?aagcacataa

721?aggtccaggc?gcaggtaaag?ttgctggaga?agcgtgtggt?gcacctgggt?gtaggaactc

781?cggggagaat?taaagaactt?gttaaacaag?gtggccttaa?tttgagcccc?ttaaaatttc

841?tggtttttga?ctggaactgg?agagatcaga?agttgaggag?aatgatggac?attcccgaga

901?taagaaagga?ggtattcgaa?cttctggaaa?tgggagtgct?cagtctgtgc?aagtcagaat

961?ccttgaaact?gggccttttc?taagtctgtg?tcctaatgaa?gattccagtt?ttcacagtag

1021?aagttgcatc?ttatttaatg?actctgatac?attgcaagca?ctcagtaaat?atcagcaaat

1081?agtttatgtt?aattgtgtca?acagatggat?cactggaatg?tggggattct?gaaacagaaa

1141?tgaaactgtc?cttttgacaa?ctctcttata?taataaagta?tcaccggctt?gtgtatgaaa

1201?aaaaaaaaaa?aaaaaaaaaa?aaaaaa

<210>21

<211>2216

<212>DNA

<213>Homo?sapiens

<400>21

1?cgtctctctg?cccccgccgc?tgccatggcg?gcagctccgc?cgctttccaa?ggccgagtat

61?ctgaagcgtt?acttgtccgg?ggcagatgcc?ggcgtcgacc?ggggatctga?gtccggtcgc

121?aagcgtcgca?aaaagcggcc?gaagcctggc?ggggccggcg?gcaagggaat?gcggattgtg

181?gatgatgatg?tgagctggac?agctatctcc?acaaccaaac?tagaaaagga?ggaagaggaa

241?gatgatggag?atttgcctgt?ggtggcagag?tttgtggatg?agcggccaga?agaggtaaag

301?cagatggagg?cctttcgttc?cagtgccaaa?tggaagcttc?tgggaggcca?caacgaagac

361?ctaccctcaa?acagacattt?tcgtcacgat?accccggatt?catctcctag?gagggtccgt

421?catggtaccc?cagatccatc?tcctaggaag?gaccgtcatg?acaccccgga?tccatctcct

481?aggagggccc?gtcatgacac?cccagatcct?tctcccctca?gaggggctcg?tcatgactca

541?gacacatctc?ctcccaggag?gatccgtcat?gactcctcag?acacttcacc?cccaaggagg

601?gcccgtcatg?attctccaga?tccttctccc?ccaaggaggc?ctcagcataa?ttcttcaggt

661?gcatctccta?ggagagtccg?tcatgattca?ccagatccct?ctcctcctag?gcgagcccgt

721?catggttcct?cagatatctc?ttcccccaga?agggtccata?acaactcccc?tgacacatct

781?aggaggactc?ttggctcttc?agacacacag?caactcagaa?gggcccgtca?tgactcccct

841?gatttggctc?ctaatgtcac?ttattccctg?cccagaacca?aaagtggtaa?agccccagaa

901?agagcctcta?gcaagacttc?tccacattgg?aaggagtcag?gagcctccca?tttgtcattc

961?ccaaagaaca?gcaaatatga?gtatgaccct?gacatctctc?ctccacgaaa?aaagcaagca

1021?aaatcccatt?ttggagacaa?gaagcagctt?gattccaaag?gtgactgcca?gaaagcaact

1081?gattcagacc?tttcttctcc?acggcataaa?caaagtccag?ggcaccagga?ttctgattca

1141?gatctgtcac?ctccacggaa?tagacctaga?caccggagct?ctgattctga?cctctctcca

1201?ccaaggagga?gacagaggac?caaatcttct?gattctgacc?tgtccccgcc?tcgaaggagt

1261?cagcctcctg?gaaagaaggc?tgcacacatg?tattctgggg?ctaaaactgg?gttggtgtta

1321?actgacatac?agcgagaaca?gcaggagctc?aaggaacagg?atcaagaaac?catggcattt

1381?gaagctgaat?ttcaatatgc?tgaaaccgta?tttcgagata?agtctggtcg?taagaggaat

1441?ttgaaactcg?aacgtttaga?gcaaaggagg?aaagcagaaa?aggactcaga?gagagatgag

1501?ctgtatgccc?agtggggaaa?agggcttgcc?cagagccggc?aacagcaaca?aaatgtggag

1561?gatgcaatga?aagagatgca?aaagcctctg?gcccgctata?ttgatgacga?agatctggat

1621?aggatgctaa?gagaacagga?aagagagggg?gaccctatgg?ccaacttcat?caagaagaat

1681?aaggccaagg?agaacaagaa?taaaaaagtg?agacctcgct?acagtggtcc?agcacctcct

1741?cccaacagat?ttaatatctg?gcctggatat?cgctgggacg?gagtggacag?atccaatgga

1801?tttgaacaga?agcgctttgc?caggcttgcc?agcaagaagg?cagtggagga?acttgcctac

1861?aaatggagtg?ttgaggatat?gtaactttcc?tgaggctgtg?ggggtggctg?ggctgtggta

1921?gtgggcatag?gcagcgagat?atccagtggt?aacagttgtc?tgtgctaata?attggagccc

1981?acacagacca?gcaacttgtt?gaatgccagt?tttgaccaca?gaagaatatt?cgagacctga

2041?tgtttggact?gaggtacctg?tacttcttgg?gtgtgacagc?accggctgtt?gctggctttc

2101?agaggaagca?ttgatttctc?attgaccagg?gtttgttctt?ggtagggttt?ttctttttct

2161?tttttaaata?aacatgtatt?tattttttta?aaaaaaaaaa?aaaaaaaaaa?aaaaaa

<210>22

<211>2034

<212>DNA

<213>Homo?sapiens

<400>22

1?gacgactcca?cgctcgcttg?ccctgattct?ctccgccctg?cacttttgcc?agctgaaggt

61?ccagggagaa?gagcaacctg?gcccacagcc?tgcaggtggc?ccagcagcag?gccgaggagc

121?tgccgcagga?gcgggagaag?ctgcaggttg?cccaggagga?gctgcagcgc?cagcgggacc

181?ggctggagga?agagcaggaa?gaggcggtgc?agaatggcgc?acgggttcgc?cgggagcttg

241?agcgcagcca?tagacaacta?gagcagctgg?aagggaagcg?ctcagtcctg?gccaaggagc

301?tggtggaggt?gagggaggcg?ctgagccgcg?ccacgctgca?acgggacatg?ctgcaggccg

361?agaagaccga?ggtggccgag?gcgctgacca?aggctgaggc?tggccgcatg?gagctcgagc

421?tctccgtgac?caagttgagg?gcagaggagg?cctccctgca?ggactccctg?tccaagctga

481?gcgccctcaa?tgagagcctt?gctcaggaca?agttggatct?gaactgcctt?gtcacccagc

541?tggaggaaga?aaaggccacg?ctgcagggcc?ggcagcggca?ggcggagcag?gaggccacag

601?tggcgccggc?agagcaggag?tggctggagg?agctgtggtt?ggagcaggag?gtggcacggc

661?agggcctgga?gggctcccta?tgagtggcgg?agcaggccca?ggaggcgctg?gagcaacagc

721?tccccacact?gcaccatgag?ctcagttggc?tgcaggagca?gctagcacag?gggatcatgt

781?tcggaccccc?aggccagccc?actgctgctc?cttggcactt?tcacggccct?ggcgtgtccc

841?cgtcatagtc?cttatcagtc?ccttgtattt?acctggtcac?cctccatctc?tgagggtatg

901?ggggccagat?ggctcttgct?gccctgatgt?tttggggggt?ctgcctgggc?ccctcctggt

961?gtgtcacacg?cgtccagtcc?tggcccccta?ggaggcagca?tggcgggagc?tggaggccga

1021?gcgggcccag?ctgcagagtc?agctgcagcg?tgagcaggag?gagctgctgg?cccggcggaa

1081?ggctgagaag?gaacagctga?gtgaggagat?tgctgccctg?cagcaggagc?atgacgaggg

1141?cctcctcctg?gccgagagcg?agaagcagca?ggccttgtct?ctgaaggagt?ctgagaagat

1201?ggcgctgtca?gagaagttga?tgggtacacg?gcacagcctg?gccaccatct?ccctggagat

1261?ggagcggcag?aaaccagatg?cccagagccg?gcaggagcag?gaccgggtag?gcctgccgtc

1321?gtagggaggc?ttgcggagca?ggagcgccct?ctttccaccg?agctatcccg?cggtttccag

1381?catcccatct?ggcggactcc?tcttcctctc?tcttctccta?ctctgggtct?tctatcctgg

1441?tgttccttga?atgcctatct?tccttttgtg?cctcggaacc?tctcacgcct?gccacaagtt

1501?actcttttcc?ttggtagttc?tgaactttaa?ataaggtaat?gcctgtaaga?atgccataaa

1561?tgctcaataa?ttgtcatctg?ttattatttt?catcagtaac?atcatctgaa?tcatcagtat

1621?tgtctgcttt?taacagctgc?atttttcatt?gtccaaatat?agtcacatac?atttgaccat

1681?tttataatta?ttgaataata?aattcgttct?gctattttac?aatgaaaaat?aatgctgcag

1741?agagcatttt?tgcacatgta?tcgtggcaga?tgtaggccag?aggctcttct?ttatccatcc

1801?tatggccaac?ctatgaatgt?atacacgttt?aatgagattt?tgccagcaat?caaagccttc

1861?agggaaaatg?tccctagctc?tttactacat?cagatcaagg?actctggata?attggcataa

1921?catcctggaa?tagctgaaac?agagatatta?ttctctgctg?tcctctgttg?tctttgtctt

1981?ttcacgtctt?aataaaagtg?ctggtgacaa?gagtgtaaaa?aaaaaaaaaa?aaaa

<210>23

<211>1514

<212>DNA

<213>Homo?sapiens

<400>23

1?cttgcatcaa?caatacttca?gtcatgatgt?ttaaaaaggg?gagctttgaa?attggaggaa

61?ccatacatcc?agttgcaatt?aagtataacc?ctcagttcgg?tgatgcattt?tggaacagta

121?gtaaatacaa?catggtgagc?tacccttcga?atgatgacca?gctgggccat?cgtctgtgac

181?gtgtggtaca?tgccccccat?gaccagagag?gaaggagaag?atgcagtcca?gtttgctaac

241?agggttaagt?ctgctattgc?tatacaagga?ggcctgactg?aacttccctg?ggatggagga

301?ctaaagagag?caaaggtgaa?ggacatcttt?aaggaagagc?agcagaaaaa?ttacagcaag

361?atgattgtgg?gcaatggatc?tctcagctaa?gaggacggat?gacagccttt?agatctagaa

421?ctagccctta?gaaatggaat?ggcttttttg?ttttgttttg?ttttattgtt?ttgtttttat

481?tattgttaat?cttttctaca?gaatgattgt?ctctacctct?ttatgccaga?ggcagaacct

541?acaggtgccc?tttttggctt?ttgttgttgt?tgtaacatta?gccccatgga?ttgtaaggtg

601?gtttactgag?ttaaaacaga?ttctgctttt?gtaaaatgat?ggcatcactg?tggactgaat

661?gaaatatttg?tatagaaaaa?agtgcttgaa?aagtgtgttt?ggaactcatc?gatagggtaa

721?ttctccaaaa?atgcccaaac?tctctttctg?taattagcct?tgccactttc?ttcagtcact

781?taaatggtga?gattacacat?cagtgcaaga?tgaccattat?ggttatggtc?tactgcaagg

841?ttgaaaggaa?aaatggagga?ttgtatttag?gaaaagggac?aactttgtgg?ccacctgctc

901?tgaaagtcaa?aaggaaatgt?aaattagtgt?cattagtgtg?ttggaagaga?aatactattc

961?agtaagcttc?gccaaagaaa?agtgagtcaa?agttaatgtg?tgtgtgcatt?tatatgtagg

1021?cagctcgtag?accacatttt?agccagcaac?tggtaacaaa?gagcttagtt?ttccttgttt

1081?gaatgctgta?gatctgtacc?tagtacccct?cccatctact?gatttgtttg?tttttgtaac

1141?caaacacatt?ttcagataga?aggagcctta?aaaaaaaaaa?aatcacattg?agtaacttca

1201?gtatgaatga?atgagagtgt?gtggagctac?ccctcaccct?ccaccccttt?gtgcttttta

1261?ttcccgaatt?ttcccagtct?cttaaacaga?aaaatgactg?atataattat?cttttggaaa

1321?ctgagcctta?atttttttta?gagggggaaa?taagttttcc?ccaactcaca?cagcataagc

1381?aatgtttgac?agcaatataa?tgccgttgta?aactactgag?agtattgtat?ctgttctggt

1441?aaccatgtac?agaatgtgaa?actgtcttat?gaatataaat?aaattctata?tttctaaaaa

1501?aaaaaaaaaa?aaaa

<210>24

<211>1010

<212>DNA

<213>Homo?sapiens

<400>24

1?acttccggtc?ggcgtgagcg?tgaggtgtgg?gtgttcgttt?ctcaggtaaa?acatggctaa

61?aagcttacgg?agtaagtgga?aaagaaagat?gcgtgctgaa?aagagaaaaa?agaatgcccc

121?aaaggaggcc?agcaggctta?aaagtattct?caaactagac?ggtgatgttt?taatgaaaga

181?tgttcaagag?atagcaactg?tggtggtacc?caaacccaaa?cattgccaag?agaaaatgca

241?atgtgaggta?aaagatgaaa?aagatgacat?gaaaatggag?actgatatta?agagaaacaa

301?aaagactctt?ctagaccagc?atggacagta?cccaatatgg?atgaaccaaa?ggcaaagaaa

361?aaggctgaag?gcaaagcgag?agaaaagaaa?ggggaaaagc?aaagcaaaag?cagtgaaagt

421?ggcaaagggt?ttggcctggt?agactcttaa?aaccttggaa?aatgccacat?gggatagatg

481?acggattaga?atgtatacac?atgtatactt?tgatttcaac?tgccaccaaa?tgaaaaccat

541?ttgttttcct?attttaactt?ggcctttttt?cttcaattca?aacccagcat?aactcctcaa

601?gtttgttttg?ggaacttgaa?taaaatattt?tctttgatac?atccaagctc?tactgatact

661?ttaactggat?gctacccaat?atccagttat?aatcaggcct?caacgttctg?tcaggtatta

721?atatggttag?aattgttctt?acaactggta?attatagtca?atagagataa?aacagatgat

781?gtactgacaa?atttttgtga?acttagattt?taaagaaagt?tgttgtataa?tcatatcatt

841?taaaaatact?acattagggc?tgggcatggt?ggctcacacc?tgtaatccca?gcactttggg

901?aggccgaggc?aggtggatca?cgaggtcagt?tcgagactag?cctggctaat?acagtgaaac

961?cccatctcta?ctaaaaatac?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa

<210>25

<211>1482

<212>DNA

<213>Homo?sapiens

<400>25

1?gaggcgccgg?cggccacgcc?gcggaaggcg?cgggccgagc?agagccgggc?gttggagccc

61?gcgcgcgcat?ggaggcgttg?ccggcagccc?cctgagggca?gcggggagac?aagacccggc

121?gacctcgcgc?atccctcgag?ccgccacgcg?ctctcgccac?cgggcggcga?cgggccgcgg

181?agccggcgcg?gccatggcga?cgggcggcca?gcagaaggag?aacacgctgc?ttcacctctt

241?cgccggcggg?tgtggaggca?cagttggtgc?tattttcact?tgtccactag?aagtcattaa

301?gacacggttg?cagtcttcaa?gattagctct?ccggacagtc?tactatcctc?aggttcatct

361?ggggaccatt?agtggagctg?gaatggtgag?accaacatcc?gtgacacctg?gactctttca

421?ggttctgaag?tcgatcttgg?agaaagaggg?accaaagtca?ctttttagag?gcttgggtcc

481?aaatttggtt?ggagttgcac?catcaagggc?tgtatacttt?gcatgttact?ccaaagccaa

541?agagcaattt?aatggcattt?tcgtgcctaa?cagcaatatt?gtgcatattt?tctcagctgg

601?ctctgcagct?tttatcacaa?attccttaat?gaatcctata?tggatggtta?aaacccgaat

661?gcagctagaa?cagaaagtga?ggggctctaa?gcagatgaat?acactccagt?gtgctcgtta

721?cgtttaccag?accgaaggca?ttcgtggctt?ctatagagga?ttaactgcct?cgtatgctgg

781?aatttccgaa?actataatct?gctttgctat?ttatgaaagt?ttaaagaagt?atctgaaaga

841?agctccatta?gcctcttctg?caaatgggac?tgagaaaaat?tccacaagtt?tttttggact

901?tatggcagct?gctgctcttt?ctaagggctg?tgcctcctgc?attgcttatc?cacacgaagt

961?cataaggacg?aggctccggg?aagagggcac?caagtacaag?tcttttgtcc?agacggcgcg

1021?cctggtgttc?cgggaagaag?gctaccttgc?cttttataga?ggactgtttg?cccagcttat

1081?ccggcagatc?ccaaatactg?ccattgtgtt?gtctacttat?gagttaattg?tgtacctgtt

1141?agaagaccgt?actcagtaac?aggccggaaa?attgtgctct?agaagaataa?aactgaaaaa

1201?ctctagagaa?ttttttttcc?ccattgatgt?ttagaaagtt?tgagactgaa?acaggaaagg

1261?ccataaaata?tctggttcat?atcacctgtt?ggacatttcc?ttttggattc?atgctttctg

1321?gaaggtttaa?attcattaac?gttaatagtt?aattataact?tttttttaac?ttaagaggat

1381?tcagggttaa?gcaccaacta?aattaaatca?tgctatttaa?tttaagtata?aaaaaaaaaa

1441?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?cc

<210>26

<211>1385

<212>DNA

<213>Homo?sapiens

<400>26

1?gcggacgatg?ccaagtccag?cagagcttgc?gctcggggct?agaagagaga?ctgagtctcc

61?cttctcagtt?tcattaggta?atgggcgaca?tggctccgtc?tccacagcgg?ggctttgctg

121?agcttagcac?gcagtctccc?ggcggggagg?aggcgcgcag?tgccgggcgc?cactccgtct

181?ccagtacgcg?ttaggcccgc?gttcccaggt?gcccgtctgg?ccgctggact?gttggccttt

241?ccggagcgag?ttttacttta?ggaagaagcc?cgggatcccg?gtagtttagc?ctgaagaaac

301?gtggggcaga?tgctgggcag?ggcggggata?ccgcgccaac?acccgctgcc?cagcggtcgc

361?cctcctatgc?agcggcgaag?ggacgcccgc?tgtgtctccg?ccctgccccc?aggcgcccca

421?gtggctggag?gtggcattct?ccactggacg?ggcgcgcctc?aatccggggg?acttccacag

481?tgctgttccc?gaggactacg?cgtctcaact?ctttgtcggg?ttccctccct?cccactgcca

541?gtctgtcttc?accgccgcgc?agacctgggg?ccgcccttca?cagaggaagg?gctccttgac

601?ctcagccacc?gtgaccccct?cctttgtgtc?acattctcag?agagttggag?ggattatgcg

661?tcatcgtaaa?cagggggaca?gagcgccttc?cacctgcggc?gcatccatta?agttccagtt

721?accctcgaga?ggattgtttt?ttccacgaaa?cccagatgca?atgagagcct?ggcttgtacc

781?atctctaagc?atcgaggctt?ccccctcgtc?tgggtggtgg?ccttcgggca?gtggctccgg

841?aaaggccatc?aaggcttccc?cgtcgtctgg?atggtggcct?tcgggcagtg?gactgtgtcc

901?atagctgaaa?accagacttg?acagttctgg?attcaggctg?ttgtgggagc?gggaaggtca

961?aacacccaga?aggaactgat?gaatgtgaat?ttccctctaa?gaactgcttt?gcctggccgg

1021?gcgcggtggc?tcacgcttgt?aattccagca?ctttgggagg?ctgaggtggg?tggatgccga

1081?ggtgagtgga?tcacgaggtc?aggagttcga?gaccagcctg?accaacatag?tgaaaccccc

1141?gtctctacta?aaaatacaaa?aattagccgg?gcctggtggc?gtgcgcctgt?aatcccagct

1201?actcgggagg?ctgagacagg?agaatcgctt?gaatccggga?ggcagaggtt?gcaggagctg

1261?agatcacgcc?attgcactcc?agcctgggca?acagagtgag?actccatctc?aaaaaaaaaa

1321?acaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa

1381?aaaaa

<210>27

<211>1503

<212>DNA

<213>Homo?sapiens

<400>27

1?cggcccccgg?gagctgtgct?ctatggagct?attgcggccg?tgggtggtcg?cgggcgatgc

61?ggggctgcca?gctcctcggg?cttcgtagct?cttggcccgg?ggacctacta?agtgctcggc

121?tcttgtccca?agagaagcgg?gcagcggaaa?cgcactttgg?gtttgagact?gtgtcggaag

181?aggagaaggg?gggcaaagtc?tatcaggtgt?ttgaaagtgt?ggctaagaag?tatgatgtga

241?tgaatgatat?gatgagtctt?ggtatccatc?gtgtttggaa?ggatttgctg?ctctggaaga

301?tgcacccgct?tcctgggacc?cagctgcttg?atgttgctgg?aggcacaggt?gacattgcat

361?tccggttcct?taattatgtt?cagtcccagc?atcagagaaa?acagaagagg?cagttaaggg

421?cccaacaaaa?tttatcctgg?gaagaaatta?ccaaagagta?ccagaatgaa?gaagattcct

481?tgggcgggtc?tcgtgtcgtg?gtgtgtgaca?tcaacaagga?gatgctaaag?gttggaaagc

541?agaaagcctt?ggctcaagga?tacagagctg?gacttgcatg?ggtattagga?gatgctgaag

601?aactgccctt?tgatgatgac?aagtttgata?tttacaccat?tgcctttggg?atccggaatg

661?tcacacacat?tgatcaggca?ctccaggaag?ctcatcgggt?gctgaaacca?ggaggacggt

721?ttctctgtct?ggaatttagc?caagtgaaca?atcccctcat?atccaggctt?tatgatctat

781?atagcttcca?ggtcatccct?gtcctgggag?aggtcatcgc?tggagactgg?aagtcctatc

841?agtaccttgt?agagagtatc?cgaaggtctc?cgtctcagga?agagttcaag?gacatgatag

901?aagatgcagg?ctttcacaag?gtgacttacg?aaagtctaac?atcaggcatt?gtggccattc

961?attctggctt?caaactttaa?ttcctttcct?atcatggagc?atgaaccagt?catatcctgt

1021?tgaaagcctg?gaactgaagg?ataatctggc?aaatgagaca?gcagcagagc?atctcctctt

1081?aaggatacgt?gccttggact?catgtttgaa?tcgaacagtc?tcaaagtgga?agaacaaatt

1141?cttgtcactt?ttttacagct?ttctttggag?ctgcttcagt?ccatctccca?gaggcatttg

1201?gtctgtatct?ttgctcaact?gctaatttct?cttggctgta?gggtgtgtgg?ttaaggtaca

1261?accaccccta?aagctcagtt?ttgaagtgag?tgtatttata?gcttctctgc?tggtgctgcc

1321?ttctagaggg?atgatagatc?atttgaaccc?aatgacaatt?tttaaccaga?aaatttaatt

1381?gtacctgaat?caacctttca?gcctaggacg?aagtctaggc?ccaagtcaga?gtattaatga

1441?tcatgagaat?tgtgtgctga?accagtaaac?gagtttacct?tttgaaaaaa?aaaaaaaaaa

1501?aaa

<210>28

<211>457

<212>DNA

<213>Homo?sapiens

<400>28

1?gtgaggtctg?gggatgagga?cagtgtgtcc?tgaaattcac?aggactgact?cctcacccca

61?gtgcacgagg?attcctgtgg?catcaggtgc?tgctgtacct?ggtgtaggag?cctaatcatg

121?aaccattgtg?ttactcacat?tccatgtcac?agaacatatc?agcctcaaga?aggatttggt

181?ggaggtggat?ttaccactgg?ttttacaaag?gaccgtgtaa?agtcattgaa?gttgtgaaag

241?tctatttttt?ttcctgtaaa?tctatttttt?acagaatata?agaaacatca?atgacctgat

301?ctgtccttcc?tcctccttcc?cgcttccccc?aaaatcacat?tccagttttt?attgtctttg

361?tgtccaaagt?aaactaggtg?acttatttgt?ataaaatgtt?attttgccac?atgagacagt

421?aataaaagaa?agattttcac?agtaaaaaaa?aaaaaaa

<210>29

<211>1685

<212>DNA

<213>Homo?sapiens

<400>29

1?gtcaaaggaa?gttagtacat?taaacaaatg?gtggtaggag?ggaggatttg?gcccaactgg

61?ctccaaccta?tctggtcaac?acgtatgttg?ggtagaacag?aggtggagaa?aagcctagat

121?cagggatgta?tacgcttcct?tggggcagac?gcagcctggc?cctgcggagc?gatttcaagc

181?ctcgttcacg?aacatggcca?aggacactgc?cagcctcttc?attcccctgt?gtggatgctc

241?caactccaaa?agtggaacca?cagggcaaat?gaatgtcggc?acgtgtcggt?atggcagcct

301?cgctcttcga?cagctggtgt?gggggttacc?acctggggct?agctggcctc?atcttcgtta

361?gcactgagac?tggtctacca?gttgcacaga?ttcagatttg?aaaatctcag?gtgcaaatcc

421?caagtggcga?tggcatgtaa?ccacatcaaa?ctcaacatct?gcacctaact?cccaccttct

481?ttctctggga?aatcttcctg?gacatgccca?gatggactca?ggagcccatc?acctgtaaat

541?ccccacactg?cagccctgcc?acttgcttgt?ctgcatgtgt?gggtccgctg?gaccactttg

601?gtgtatcttt?gagccccttg?agtgaaaaaa?tgctgcctgg?ctggctccct?gattagacat

661?ccaacataat?gaggactaac?accaatacaa?acacttaaga?gatgacatat?cgccctagct

721?ggatctacta?cagggaaggg?aagagggtgc?tgggtccagg?caggctgagt?gtctcatgtc

781?ttaatgcttc?tctgcccaat?ctatttccgg?ctggatgtgg?agtctgaagg?cctggcaccc

841?actctggctc?tgtgatttac?cagctgtgag?ccttggggga?gctgcttact?ctcttggtga

901?ttcttttctc?atttctatga?tggggtagag?gataatgcct?atgcttacaa?agtggctgtg

961?ggaagtaaac?cggatgggat?aagaatggct?tgctgtggac?cacaggcacc?gcaggataac

1021?cattcctcag?aactcctcgt?actgctctag?tgcttggagg?tccgtgtatt?acctcagcta

1081?ttccaaccgc?accaaccacg?ggagccacgt?gtctacgtct?gacagataaa?gatgctgagt

1141?ttagagtctg?caaggcttga?caaccacaga?tcagggacag?gagctgaggt?ctcctgacct

1201?ggagcccagg?gccacccgga?gctgcaagaa?acctgcactc?acaactgcct?cctattttaa

1261?aatgctgagt?cgatcccaca?ggtggcaaac?cagttctggg?cttcaattta?caagcagtca

1321?gaaaagctgg?gttgaaatcg?ccactgtcct?tctatgtggc?tgatgaggaa?ggatgacggt

1381?gcccaccgct?ccatctctcc?agctgacccc?aagctggcac?tcacgggtgg?gcaggctcag

1441?acaggcccag?ctccaccaag?tgcacttgaa?gccggaatgc?aagacatccg?atggtatact

1501?tactcgaacc?cgtccttttc?acaacagccg?cgggatccgc?tttctttggc?tgactgctca

1561?gagtcttccc?ttttcctgtg?accccattag?acgccatggg?gggcttttta?cccttgagct

1621?gttgaaataa?acatataaga?acattaaaaa?taaacacaaa?gtcaaacaaa?aaaaaaaaaa

1681?aaaaa

<210>30

<211>1421

<212>DNA

<213>Homo?sapiens

<400>30

1?ctaaaccttc?acccctgagc?acgctcagtg?agactggtca?tgcaagcatt?tacagtgcca

61?tgctcctcaa?gccgattttt?tcttgtagaa?atgttgccct?atttgtcttc?tccaatgtat

121?ggtatgttat?tttattttat?tattttattt?tattttattt?tattttatcg?agggggggta

181?cgatacctgc?catttaagaa?aatgaataga?aaattttaaa?acccgagaaa?tgggggaaaa

241?aaaatcagtg?cacaagaatt?gggctggtta?ggcccagcac?cacactgaag?tgggctcagt

301?ggtttttgga?gtgaagaagc?cttactccct?gcacattccc?tcatgctccc?acacaagtcc

361?agcaatggaa?atgcttgggt?tcctcttgct?ttgtcagggg?actcaggagt?cgaccaaggg

421?aaaccatttg?gccccgtgag?gaatgggcat?tgtcagtatc?cgtcctgaac?ggggcctagt

481?caggaagcgg?tctagaagtg?tacggtcacg?gtcgcctcat?gaaagtgtgt?agcaggtggc

541?tctcaggaaa?aataccaagt?ctggatcatc?catgtggcag?ctttgcatag?ggagaggata

601?gctccgaact?ggaactgaac?tgccttctct?gcacgcttga?ccaaagcagt?gatgagggcg

661?gccagtacct?gcggtgtgcg?tggtaggttt?aaagaaaagg?gaatgttttc?tgctgagtgt

721?ttcctttgtc?cttgggctgc?tcgagctgga?cagtaggtaa?ccactgtttt?caaggaccag

781?cccaatttct?ctggcttggt?tcggagttcg?tttcatccct?agctgtgagt?gccttttggt

841?ctggaaagtt?ggcttgtctc?ataataccca?cagctaggac?attctctctg?taattatgaa

901?ttgtccttgt?tttacattaa?aagagaatgt?ctttgatcac?tagagtctgt?cggtgttgga

961?ttatttccac?tgtgagattc?ttaaaacttt?tttgcttcat?aataataaaa?caactcatgt

1021?tagagaccct?ttcaacatga?aaggtttgta?gttgagacat?tacatatatt?ttattgttta

1081?taataaaaat?catctataca?aaagaagtcc?tgggtgttaa?tattttgcac?aagatctgtt

1141?ttccatgatg?tgttgacatc?tacaatttca?ctaactgttg?acgttatttt?ctattgagat

1201?tctggagcct?agggagctat?gtgttctttt?tgttcatttc?gttcttactt?ccctgaagca

1261?agagactata?tggccttcag?tgcaaagact?tcagaccaat?tctttgtatt?acacttggtt

1321?gcctcttggc?tatataactt?ctgagtgcaa?atcattgaac?actttaacga?agtattgtag

1381?agaataaatc?ataatggata?aaaaaaaaaa?aaaaaaaaaa?a

Claims (3)

1. human liver related gene, it comprises the gene of following sequence:

(a) sequence shown in SEQ ID No.1～SEQ ID No.30;

(b) complementary sequence of every sequence in the sequence shown in SEQ ID No.1～SEQ ID No.30;

(c) with the sequence shown in SEQID No.1～SEQ ID No.30 in every sequence the sequence of at least 70% homology is arranged, and

(d) one or several combination in above-mentioned (a)～(c).

2. human liver related gene according to claim 1 is characterized in that: described human liver related gene comprise have SEQ ID No.1～SEQ ID No.30 shown in the gene of sequence.

3. probe molecule, it is characterized in that: described probe molecule contains about 8-100 successive Nucleotide in the sequence described in the claim 1.