CN1957981A - Extractive of red sage root, preparation and producing method - Google Patents
Extractive of red sage root, preparation and producing method Download PDFInfo
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- CN1957981A CN1957981A CN 200510015890 CN200510015890A CN1957981A CN 1957981 A CN1957981 A CN 1957981A CN 200510015890 CN200510015890 CN 200510015890 CN 200510015890 A CN200510015890 A CN 200510015890A CN 1957981 A CN1957981 A CN 1957981A
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- radix salviae
- salviae miltiorrhizae
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- miltiorrhizae extract
- described radix
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- 238000002360 preparation method Methods 0.000 title claims description 25
- 238000000034 method Methods 0.000 title claims description 7
- 240000007164 Salvia officinalis Species 0.000 title abstract description 4
- 235000005412 red sage Nutrition 0.000 title abstract description 4
- 239000000284 extract Substances 0.000 claims abstract description 34
- AIGAZQPHXLWMOJ-UHFFFAOYSA-N Tanshinone I Chemical compound C1=CC2=C(C)C=CC=C2C(C(=O)C2=O)=C1C1=C2C(C)=CO1 AIGAZQPHXLWMOJ-UHFFFAOYSA-N 0.000 claims abstract description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000001035 drying Methods 0.000 claims abstract description 3
- 239000000843 powder Substances 0.000 claims description 11
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical class [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims description 4
- 235000019219 chocolate Nutrition 0.000 claims description 4
- 238000002481 ethanol extraction Methods 0.000 claims description 4
- 229910001385 heavy metal Inorganic materials 0.000 claims description 4
- 239000002304 perfume Substances 0.000 claims description 4
- 235000013599 spices Nutrition 0.000 claims description 4
- 238000001291 vacuum drying Methods 0.000 claims description 3
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 238000004811 liquid chromatography Methods 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 abstract description 10
- 239000007788 liquid Substances 0.000 abstract description 3
- 229930183118 Tanshinone Natural products 0.000 abstract description 2
- 238000001816 cooling Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 9
- 239000013558 reference substance Substances 0.000 description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000001514 detection method Methods 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 description 2
- XYKZSUXWBGUGQV-UHFFFAOYSA-N 4,8-dimethylnaphtho[2,1-f][1]benzofuran-7,11-dione Chemical compound CC1=CC=CC2=C(C(C=3OC=C(C=3C3=O)C)=O)C3=CC=C21 XYKZSUXWBGUGQV-UHFFFAOYSA-N 0.000 description 2
- GVKKJJOMQCNPGB-JTQLQIEISA-N Cryptotanshinone Chemical compound O=C1C(=O)C2=C3CCCC(C)(C)C3=CC=C2C2=C1[C@@H](C)CO2 GVKKJJOMQCNPGB-JTQLQIEISA-N 0.000 description 2
- GVKKJJOMQCNPGB-UHFFFAOYSA-N Cryptotanshinone Natural products O=C1C(=O)C2=C3CCCC(C)(C)C3=CC=C2C2=C1C(C)CO2 GVKKJJOMQCNPGB-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- PAFLSMZLRSPALU-MRVPVSSYSA-N (2R)-3-(3,4-dihydroxyphenyl)lactic acid Chemical compound OC(=O)[C@H](O)CC1=CC=C(O)C(O)=C1 PAFLSMZLRSPALU-MRVPVSSYSA-N 0.000 description 1
- SNKFFCBZYFGCQN-UHFFFAOYSA-N 2-[3-[3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyloxy]-3-(3,4-dihydroxyphenyl)propanoic acid Chemical compound C=1C=C(O)C=2OC(C=3C=C(O)C(O)=CC=3)C(C(=O)OC(CC=3C=C(O)C(O)=CC=3)C(O)=O)C=2C=1C=CC(=O)OC(C(=O)O)CC1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-UHFFFAOYSA-N 0.000 description 1
- YMGFTDKNIWPMGF-AGYDPFETSA-N 3-(3,4-dihydroxyphenyl)-2-[(e)-3-[2-[(e)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid Chemical compound C=1C=C(O)C(O)=C(\C=C\C=2C=C(O)C(O)=CC=2)C=1/C=C/C(=O)OC(C(=O)O)CC1=CC=C(O)C(O)=C1 YMGFTDKNIWPMGF-AGYDPFETSA-N 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 241000331777 Arisaema balansae Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- PAFLSMZLRSPALU-QMMMGPOBSA-N Danshensu Natural products OC(=O)[C@@H](O)CC1=CC=C(O)C(O)=C1 PAFLSMZLRSPALU-QMMMGPOBSA-N 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- -1 IIA Chemical compound 0.000 description 1
- SNKFFCBZYFGCQN-VWUOOIFGSA-N Lithospermic acid B Natural products C([C@H](C(=O)O)OC(=O)\C=C\C=1C=2[C@H](C(=O)O[C@H](CC=3C=C(O)C(O)=CC=3)C(O)=O)[C@H](OC=2C(O)=CC=1)C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-VWUOOIFGSA-N 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 description 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 1
- PAFLSMZLRSPALU-UHFFFAOYSA-N Salvianic acid A Natural products OC(=O)C(O)CC1=CC=C(O)C(O)=C1 PAFLSMZLRSPALU-UHFFFAOYSA-N 0.000 description 1
- YMGFTDKNIWPMGF-QHCPKHFHSA-N Salvianolic acid A Natural products OC(=O)[C@H](Cc1ccc(O)c(O)c1)OC(=O)C=Cc2ccc(O)c(O)c2C=Cc3ccc(O)c(O)c3 YMGFTDKNIWPMGF-QHCPKHFHSA-N 0.000 description 1
- GCJWPRRNLSHTRY-UHFFFAOYSA-N Salvianolic acid C Natural products C=1C=C(O)C=2OC(C=3C=C(O)C(O)=CC=3)=CC=2C=1C=CC(=O)OC(C(=O)O)CC1=CC=C(O)C(O)=C1 GCJWPRRNLSHTRY-UHFFFAOYSA-N 0.000 description 1
- GCJWPRRNLSHTRY-VURDRKPISA-N Salvianolic acid C Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=2C=C(OC=2C(O)=CC=1)C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 GCJWPRRNLSHTRY-VURDRKPISA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- OAMZXMDZZWGPMH-UHFFFAOYSA-N ethyl acetate;toluene Chemical compound CCOC(C)=O.CC1=CC=CC=C1 OAMZXMDZZWGPMH-UHFFFAOYSA-N 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 244000132619 red sage Species 0.000 description 1
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 description 1
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- STCJJTBMWHMRCD-UHFFFAOYSA-N salvianolic acid B Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=O)C=Cc2cc(O)c(O)c3OC(C(C(=O)OC(Cc4ccc(O)c(O)c4)C(=O)O)c23)c5ccc(O)c(O)c5 STCJJTBMWHMRCD-UHFFFAOYSA-N 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011003 system suitability test Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Abstract
A red sage root extract containing tanshinone (not less than 0.40%) is prepared through pulverizing red sage root, extracting in alcohol 2-4 times, collecting liquid extract, filtering, concentrating, cooling and drying. A medicine containing it is also disclosed.
Description
Technical field
The present invention relates to the technical field of salviamiltiorrhizabung, particularly the technical field of Radix Salviae Miltiorrhizae extract, preparation and preparation method thereof.
Background technology
Chinese medicine extract is the emerging field that differentiation is come out from the Chinese medicine industry, is the deep processing to Chinese crude drug.The essence of Chinese medicine extract is the raw material of Chinese medicine medicine, has less investment, with high content of technology, advantage and characteristics such as added value of product is big, the international market is extensive.Chinese medicine extract has possessed certain industry size through years of development, and export ratio has surpassed Chinese medicine, and presents ascendant trend.At present, Jue Daduoshuo Chinese medicine extract does not have national standard or industry standard.
Radix Salviae Miltiorrhizae (Radix Salviae Miltiorrhizae), another name blood is taken root, Radix Salviae Miltiorrhizae, Herba Wedeliae Wallichii, Arisaema balansae Engl., is labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge. root and rhizome.Chemical constituent: fat-soluble composition is as containing Tanshinone I, IIA, IIB iso tanshinone I, IIA, cryptotanshinone, different cryptotanshinone, methyltanshinone, hydroxyl TANSHINONES etc.Water-soluble components is as danshensu, salvianolic acid A, salvianolic acid B, salvianolic acid C, rosmarinic acid etc.The nature and flavor cold nature, bitter in the mouth.Function cures mainly: stasis-dispelling and pain-killing, and promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for that menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection are swollen and ache, hepatosplenomegaly, angina pectoris.
Thereby Radix Salviae Miltiorrhizae extract is a Radix Salviae Miltiorrhizae to be prepared into preparation and finally to be applied to clinical basis, and its quality will have influence on the quality of red sage formulation, does not still have national standard at present or industry standard is come standard.
Summary of the invention
The present invention is intended to solve the standardization issue of Radix Salviae Miltiorrhizae extract.
In order to address the above problem, the invention provides a kind of Radix Salviae Miltiorrhizae extract, wherein Tanshinone I I
A(C
19H
18O
3), be no less than 0.40% according to high effective liquid chromatography for measuring.
Described Radix Salviae Miltiorrhizae extract, preferred situation is: its character is a chocolate brown powder, gas perfume (or spice), bitter in the mouth; Moisture is no more than 5.0%; Residue on ignition is no more than 0.8%; Heavy metal is no more than 15/1000000ths; Arsenic salt is no more than 2/1000000ths.
The present invention also aims to provide a kind of preparation that contains Radix Salviae Miltiorrhizae extract.Said preparation is any preparation that can be made by above-mentioned Radix Salviae Miltiorrhizae extract, includes but not limited to: liquid preparation, injection, powder, drop pill, tablet, capsule, microcapsule etc.Those skilled in the art can adopt the technical method of this area routine to prepare above-mentioned preparation.
The present invention also aims to provide a kind of preparation method of Radix Salviae Miltiorrhizae extract, comprise the steps:
A. get Radix Salviae Miltiorrhizae, be ground into coarse powder;
B. add 8-12 and doubly measure 70% ethanol extraction 2-4 time, each 1-2 hour;
C. collecting decoction filters;
D. concentrate;
E. put cold;
F. dry.
The preparation method of described Radix Salviae Miltiorrhizae extract can also comprise the step of immersion between step a and step b, 70% ethanol is 10 times of amounts, extracts each 1.5 hours 3 times; Method for concentration among the step c is a concentrating under reduced pressure below 60 ℃; The drying of step f adopts the crawler type vacuum drying oven to carry out.
The invention provides the preparation that a kind of Radix Salviae Miltiorrhizae extract, Radix Salviae Miltiorrhizae extract make and the preparation method of Radix Salviae Miltiorrhizae extract, solved the standardization issue of Radix Salviae Miltiorrhizae extract.
The specific embodiment
Below with bright the present invention specifically, embodiment is for the ease of understanding the present invention, and claim that does not limit the present invention in any way and core content.
The preparation of embodiment 1 Radix Salviae Miltiorrhizae extract
Get Radix Salviae Miltiorrhizae, be ground into coarse powder, soaked 30 minutes, add 10 times of amount 70% ethanol extractions 3 times, each 1.5 hours, collecting decoction filtered, and filtrate is in being evaporated to the clear paste that relative density is 1.30-1.35 (60 ℃) below 60 ℃, put cold, crawler type vacuum drying oven drying, promptly.
The detection of embodiment 2 embodiment 1 described Radix Salviae Miltiorrhizae extract
Character: be chocolate brown powder, gas perfume (or spice), bitter in the mouth.
Differentiate: get this product powder 0.2g, add ethyl acetate 2ml, supersound process 20 minutes filters, and filtrate is as need testing solution.Other gets Tanshinone I I
AReference substance adds ethyl acetate and makes the solution that every 1ml contains 1mg, in contrast product solution.According to thin layer chromatography (appendix VIB) test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, be developing solvent with toluene-ethyl acetate (19: 1), launch, take out, dry.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
Check
Moisture: the photograph aquametry (" 2000 editions appendix IX of Chinese pharmacopoeia H, first method) measure, be no more than 5.0%.
Residue on ignition: get this product 1g, photograph residue on ignition algoscopy (" 2000 editions appendix IX of Chinese pharmacopoeia J) measure, be no more than 0.8%
Heavy metal: get this product 0.5g (" 2000 editions appendix IX of Chinese pharmacopoeia B) and check in accordance with the law, be no more than 15/1000000ths.
Arsenic salt: get this product 0.5g (" 2000 editions appendix IX of Chinese pharmacopoeia B) and check in accordance with the law, be no more than 2/1000000ths.
Assay:
Tanshinone I I
AMeasure according to high performance liquid chromatography (" 2000 editions appendix VI of Chinese pharmacopoeia D).
Chromatographic condition and system suitability test are filler with the octadecylsilane chemically bonded silica; With methanol-water (75: 25) is mobile phase; The detection wavelength is 270nm.Number of theoretical plate is pressed Tanshinone I I
AThe peak calculates, and should be not less than 2500.
The preparation precision of reference substance solution takes by weighing Tanshinone I I
AReference substance 4.1mg places the 10ml volumetric flask, shakes up with methanol constant volume to scale, and precision is measured 1 milliliter and put in the brown measuring bottle of 10ml,, shakes up to scale with methanol constant volume, makes the Tanshinone I I of 0.041mg/ml
AReference substance solution.
The about 0.4g of this product powder (crossing sieve No. 4) is got in the preparation of need testing solution, and accurate the title decides, and puts in the tool plug conical flask, and the accurate methanol 25ml that adds claims to decide weight, supersound process 20 minutes is taken out, and puts coldly, claims to decide weight again, supplies the weight that subtracts mistake with methanol, shake up, filter, get subsequent filtrate, promptly.
Accurate respectively reference substance solution and each the 5 μ l of need testing solution of drawing of algoscopy inject chromatograph of liquid, measure, promptly.
This product contains Tanshinone I I in dry product
A(C
19H
18O
3) must not be less than 0.40%
The preparation of embodiment 3 Radix Salviae Miltiorrhizae extracts
Get Radix Salviae Miltiorrhizae, be ground into coarse powder, soaked 30 minutes, add 8 times of amount 70% ethanol extractions 4 times, each 1 hour, collecting decoction filtered, and the filtrate rotary evaporation is concentrated into the clear paste that relative density is 1.30-1.35 (60 ℃), put cold, spray drying, promptly.
The detection of embodiment 4 embodiment 3 described Radix Salviae Miltiorrhizae extracts
Detection method is carried out the result according to embodiment 2:
Character: be chocolate brown powder, gas perfume (or spice), bitter in the mouth.
Differentiate: get Tanshinone I I
ABe reference substance, in the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
Check:
Moisture: be no more than 5.0%.
Residue on ignition: be no more than 0.8%
Heavy metal: be no more than 15/1000000ths.
Arsenic salt: be no more than 2/1000000ths.
Assay
This product contains Tanshinone I I in dry product
A(C
19H
18O
3) be no less than 0.40%.
Claims (8)
1. a Radix Salviae Miltiorrhizae extract, wherein Tanshinone I I
A(C
19H
18O
3), be no less than 0.40% according to high effective liquid chromatography for measuring.
2. the described Radix Salviae Miltiorrhizae extract of claim 1, it is characterized in that: character is a chocolate brown powder, gas perfume (or spice), bitter in the mouth; Moisture is no more than 5.0%; Residue on ignition is no more than 0.8%; Heavy metal is no more than 15/1000000ths; Arsenic salt is no more than 2/1000000ths.
3. claim 1 or the made preparation of 2 described Radix Salviae Miltiorrhizae extracts.
4. the preparation method of the described Radix Salviae Miltiorrhizae extract of claim 1 comprises the steps:
A. get Radix Salviae Miltiorrhizae, be ground into coarse powder;
B. add 8-12 and doubly measure 70% ethanol extraction 2-4 time, each 1-2 hour;
C. collecting decoction filters;
D. concentrate;
E. put cold;
F. dry.
5. the preparation method of the described Radix Salviae Miltiorrhizae extract of claim 3 is characterized in that also having the step of soaking between step a and step b.
6. the preparation method of the described Radix Salviae Miltiorrhizae extract of claim 3 is characterized in that the time of soaking among the step b is 30 minutes, and 70% ethanol is 10 times of amounts, extracts each 1.5 hours 3 times.
7. the preparation method of the described Radix Salviae Miltiorrhizae extract of claim 3 is characterized in that the method for concentration among the step c is a concentrating under reduced pressure below 60 ℃.
8. the preparation method of the described Radix Salviae Miltiorrhizae extract of claim 3 is characterized in that the drying of step f adopts the crawler type vacuum drying oven to carry out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510015890 CN1957981A (en) | 2005-11-04 | 2005-11-04 | Extractive of red sage root, preparation and producing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510015890 CN1957981A (en) | 2005-11-04 | 2005-11-04 | Extractive of red sage root, preparation and producing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1957981A true CN1957981A (en) | 2007-05-09 |
Family
ID=38069933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510015890 Pending CN1957981A (en) | 2005-11-04 | 2005-11-04 | Extractive of red sage root, preparation and producing method |
Country Status (1)
| Country | Link |
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| CN (1) | CN1957981A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012938B2 (en) | 2010-04-09 | 2015-04-21 | Cree, Inc. | High reflective substrate of light emitting devices with improved light output |
| CN108991415A (en) * | 2018-06-29 | 2018-12-14 | 襄阳三珍生态农业有限公司 | A kind of production method of nutrition acorn nut huyashi-chuuka (cold chinese-style noodles) |
-
2005
- 2005-11-04 CN CN 200510015890 patent/CN1957981A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012938B2 (en) | 2010-04-09 | 2015-04-21 | Cree, Inc. | High reflective substrate of light emitting devices with improved light output |
| CN108991415A (en) * | 2018-06-29 | 2018-12-14 | 襄阳三珍生态农业有限公司 | A kind of production method of nutrition acorn nut huyashi-chuuka (cold chinese-style noodles) |
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