CN1950073A - Nutritional composition for increasing creatine uptake in skeletal muscle - Google Patents
Nutritional composition for increasing creatine uptake in skeletal muscle Download PDFInfo
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Abstract
A nutritional composition, the consumption of which provides a method for increasing creatine accumulation, building muscle size, increasing thermogenesis, reducing body fat mass leading to weight loss and/or improving muscular definition. The nutritional composition may include an aqueous solution of cinnamon and creatine. In addition, the nutritional composition may also include alpha lipoic acid. A method of manufacturing the nutritional composition is also provided.
Description
Related application
The U.S. Provisional Patent Application of submitting in the U.S. Provisional Patent Application 60/569,049 that the application and on May 7th, 2004 submit and on June 15th, 2,004 60/580,114 is relevant, and above-mentioned every piece of document inserts herein by reference in full.
Technical field
The present invention relates to sarcosine retentivity in vivo, more specifically (but not only) relates to for the purpose of for example building up muscle and is used for increasing the cumulative method and composition of sarcosine at human body.In addition or replacedly, the present invention also provides in order for example to reduce the body fat quality is used for increasing animal themogenesis with the purpose that loses weight and improve muscle lines (muscular definition) method and composition.
Background technology
In recent years, experiment in vitro has shown that the polyphenol polymer in the aqueous extract that is included in Cortex Cinnamomi (various Cinnamomum mutation) improves the metabolism of grape cell sugar.Verified: by phosphorylation that promotes Insulin receptor INSR and the dephosphorylation that passes through to suppress insulin receptor kinase, these extracts can trigger the insulin cascade system and strengthen the activity of insulin, thereby increase the sensitivity of insulin and stimulate the absorption of glucose and synthesizing of glycogen (glycogen).
Up-to-date sign+chemical constitution and the previous cinnamon derivative of reporting, MHCP-methyl hydroxy chalcone polymer is very relevant.From chemical terms, these polyphenol polymers are two bonding types-A procyanidolic oligomers of catechin/epicatechin.
Research has proved that cinnamon extract (be consumed or be consumed with 30-300mg/kg/ days amount with 2% amount of all foodstuffs) can dosage improve the level of plasma glucose, insulin and triglyceride with relying on and increase the absorption of glucose in the skeletal muscle in the body of a series of animals---to small part by improving insulin signalingization (promptly, increase the level of IR-β activation and IRS-1 tyrosine phosphorylation, be increased to IRS-1/PI 3-kinases synergism higher) and realize by nitric oxide (NO) pathway activation.
And animal experiment has shown that cinnamomic replenishing has positive impact to glucose and lipid metabolism.In a research, in 6 health female object of study, the edible Cortex Cinnamomi of single dose (55mg/kg b.w.) is obviously alleviated (P=0.02) glucose responding (glycemic response) to the 75g glucose.Zone below glucose curve reduces along with cinnamomic consumption, and this may be to realize by the activity that improves insulin.
The placebo-controlled study of recently carrying out in the 2-diabetes mellitus type shows, daily moderate absorbs table Cortex Cinnamomi (table cinnamon) (promptly, capsular form with 500mg consumes 1-6g every day, after main the dining, take immediately, continuous 40 days) can reduce average fasting serum glucose, triglycerides, LDL cholesterol and total cholesterol level (simultaneously, noticing not variation in the object of study of placebo group) safely.
What is interesting is that this research has also been reported, when individuality cut out Cortex Cinnamomi in the time of 20 days, still keeps lower serum glucose and class lipid level, this has hinted that Cortex Cinnamomi does not need be consumed every day.According to this research, the key component that causes the cinnamon bark of hypoglycemia effect be can be water-soluble polyphenol polymer, this can be water-soluble polyphenol polymer with any amount nontoxic (but opposite with cinnamomic liposoluble chemical compound, but if the long-term absorption of this cinnamomic liposoluble chemical compound can accumulate in vivo).And the Cortex Cinnamomi level of testing in this research hints, have the useful Cortex Cinnamomi intake of wide region, and the intake of every day＜1g is useful to blood sugar control and blood lipid level.
Experiment in vitro shows that cinnamomic extract stimulates the glycogen synthase, increases glucose absorption and suppress glycogen synthase kinase-3 β.Show that also cinnamomic extract stimulates insulin receptor kinase and suppresses the dephosphorylation of Insulin receptor INSR.All these effects will cause the increase of insulin sensitivity.
Improve the effect that as if another mechanism of action that grape cell sugar absorbs be that the polyphenol part will be exerted one's influence to endothelium nitric oxide (NO) later on consuming cinnamon extract.Have following evidence, polyphenolic substance can the dependent diastole effect of induction of vascular endothelial, and this effect be since strengthen NO synthetic, strengthen the biological activity of NO and protect it to avoid being subjected to O
2Influence is decomposed and is caused.Strengthen the synthetic of NO and improve its biological activity and will guarantee to increase blood flow (also regulating), thereby support following viewpoint: the conveying in the tissue of modulation blood flow decision glucose absorption and glucose via enhanced insulin-mediated vasodilation.
In addition, can think: the slow excite state bioavailability of increase is to adopt cinnamon extract to replenish the possible mechanism of improving the grape cell sugar metabolism.In fact, recent investigation has shown butein (promptly, 3 of the plant Rhus Verniciflua that extensively adopts in the next comfortable Korea S medicine among the people, 4,2,4 '-the tetrahydroxy chalcone derivative) be and the similar polyphenol of the compound structure of in the Cortex Cinnamomi aqueous extract, finding that it has hypotensive effect by suppressing angiotensin invertase (ACE).This inhibitory action may mediate by producing chelant complex with zinc ion in the active center of ACE, and this makes the active inactivation of ACE.
Recently the human research is verified, and the ACE inhibitory action improves glucose distribution speed and owing to increase muscle glucose absorption (MGU), this effect is main.Under the glucagon condition, ACE inhibitor can also improve the distribution and the glucose transport activity of overall glucose in skeletal muscle.The production of the level of the inhibiting effect of Hemodynamics on Pathogenesis of ACE and enhanced vasodilation peptide Kallidin I (BK) and the vasoconstrictor of reduction and somatomedin angiotensin II (ATII) is relevant.These results are not astonishing, because, the ACE that is equal to BK degraded kininase II is a large amount of exist with muscular tissue in, and shown that its inhibitory action causes viewed metabolism by the tissue concentration of increase BK with by the BK acceptor site (B2) in muscle and/or endothelial tissue.
Be applied to the speed that external source BK in the arm shape tremulous pulse of human body forearm not only increases muscle blood flow (MBF) but also strengthens MGU.In another investigation, during rhythmical active was shunk, the two increased MBF and MGU in response to the increase of higher energy expenditure response and BK release in blood vessel, and this process consumes the muscular tissue in (drain) work.
On cellular level, ACE inhibitor strengthens the absorption of glucose in glucagon skeletal muscle tempestuously via following two mechanism.A mechanism comprises the effect of Kallidin I, works with generation and the final transhipment that improves glucose that increases NO by bradykinin b 2 receptor.Second mechanism comprises the inhibitory action that reduces ATII, by angiotensin receptor (AT
1) in skeletal muscle glucose transport system, work.
ACE inhibitor is relevant with the just adjusting (upregulation) of insulin signaling (comprising enhanced IRS-1 tyrosine phosphorylation effect and phosphatidylinositol-3-kinase activity) to the violent effect of skeletal muscle glucose transport, and finally relevant with the cell surface GLUT-4 glucose transporter that increases.With ACE inhibitor or AT
1Antagonist slowly gives the protein expression that the glucagon rodent can increase the GLUT-4 in skeletal muscle and the cardiac muscle.
These data are supported following viewpoint, and ACE inhibitor can be regulated glucose control (can pass through the NO dependence effect of the Kallidin I on skeletal muscle and/or the antagonism of ATII behavior) valuably under the glucagon state.
This is very important, because, in research in recent years, having hinted that insulin can cause its behavior via quickening to discharge the endothelium endogenous nitric oxide on MBF and MGU, this NO production also stimulates by the BK that is concentration dependent.Because Kallidin I also is the culture medium of ACE, thus possible be that ACE inhibitory action by the Cortex Cinnamomi hydroxy chalcone can also cause the bioavailability of Kallidin I to increase, thereupon the transporting ability of GLUT4 increase and skeletal muscle tissue in the absorption of glucose increase.
Summary of the invention
The invention provides a kind of animal (for example, the mankind) uses supplementary, this supplementary to provide muscle to make up performance and/or thermogenesis performance.In preferred embodiment, alimentation composition comprises cinnamomic aqueous extract and sarcosine.In a this embodiment, provide sarcosine with two sarcosine malate forms.In addition, supplementary can comprise following illustrated other composition, especially alpha-lipoic acid.
The present invention also provides the method and composition that is used for replenishing animal diet followed, and this method comprises that giving the animal portion provides the supplementary that makes up muscle performance and/or thermogenesis performance.In preferred embodiment, the invention provides the method and composition that is used for replenishing animal diet followed, this method comprises and gives the alimentation composition that the animal portion comprises Cortex Cinnamomi aqueous extract and sarcosine, and, this alimentation composition can also comprise other composition, especially alpha-lipoic acid.
The present invention also provides the purpose for for example build up muscle (build muscle size) to be used for increasing the cumulative method and composition of sarcosine at the skeletal muscle of animal.In addition or replacedly, the present invention also provides in order for example to reduce that the body fat amount loses weight and the purpose of improving the muscle lines is used for increasing animal the method and composition of themogenesis.
According to an embodiment of the invention, this method comprises the steps:
A. comprise a sarcosine and Cortex Cinnamomi aqueous extract supplementary and;
B. increase the total muscle sarcosine in the animals skeletal muscle.
The present invention also provides the method that is used to make supplementary.According to an embodiment of the invention, a kind of method of making supplementary is provided, this supplementary comprises sarcosine, alpha-lipoic acid and/or cinnamomic aqueous extract.In one embodiment, this method comprises the steps:
A. with microcrystalline Cellulose and sarcosine, thioctic acid and cinnamomic aqueous extract premixing;
B. add through pre-magnesium stearate and the tripoli that sieves;
C. allotment mixed 30 minutes;
D. verification uniformity/homogeneity, five equilibrium composition then.
The specific embodiment
The invention provides a kind of animal (for example, the mankind) uses supplementary, this supplementary to provide muscle to make up performance and/or thermogenesis performance.In preferred embodiment, alimentation composition comprises cinnamomic aqueous extract and sarcosine.In a this embodiment, provide sarcosine with two sarcosine malate forms.In addition, supplementary can comprise following illustrated other composition, especially alpha-lipoic acid.
The present invention also provides the method and composition that is used for replenishing animal diet followed, and this method comprises that giving the animal portion provides the supplementary that makes up muscle performance and/or thermogenesis performance.In preferred embodiment, the invention provides the method and composition that is used for replenishing animal diet followed, this method comprises and gives the alimentation composition that the animal portion comprises Cortex Cinnamomi aqueous extract and sarcosine, and, this alimentation composition can also comprise other composition, especially alpha-lipoic acid.
The present invention also provides and be used to increase the cumulative method of sarcosine in animals skeletal muscle, and this method comprises the steps:
A. comprise a sarcosine and Cortex Cinnamomi aqueous extract supplementary and;
B. increase the total muscle sarcosine in the animals skeletal muscle.
It is believed that picked-up comprises that the sarcosine supplement of Cortex Cinnamomi aqueous extract are higher than the level of sarcosine cumulative rises in skeletal muscle and give sarcosine resulting sarcosine accumulation level separately.Simultaneously do not wish to be subjected to the limitation of any theory, think that cinnamomic extract promotes the phosphorylation of Insulin receptor INSR and suppresses the dephosphorylation of Insulin receptor INSR, it is synthetic and increase the bioavailability of Kallidin I to strengthen NO.All these effects will cause the increase of insulin sensitivity.Increase in the plasma insulin increases the activity of sodium dependency muscle sarcosine transport protein.This theory supported by the following fact, when insulin have concentration 〉=100mU/l the time, its increases the cumulant of the muscle sarcosine in human body.
" total muscle sarcosine " used herein refers to whole phosphoric acid sarcosine (phosphocreatine) and whole free sarcosine in the skeletal muscle.Those skilled in the art will appreciate that the total about 124mmol/kg dry weight of muscle sarcosine average out to (dm) that in healthy, non-vegetarian diet object of study, stores, but in that it can change in the wide region of the about 150mmol/kg dm of about 100-between the Different Individual.In preferred embodiment, the free sarcosine (absorb 0.1-1g Cortex Cinnamomi aqueous extract/5g sarcosine every day four times, absorb 5 days) that picked-up has the Cortex Cinnamomi aqueous extract can make total muscle sarcosine increase at least about 24mmol/kg dm.In preferred embodiment, the free sarcosine (absorb 0.1-1g Cortex Cinnamomi aqueous extract/5g sarcosine every day four times, absorb 5 days) that picked-up has the Cortex Cinnamomi aqueous extract can make the about 28mmol/kg dm of total muscle sarcosine increase.In most preferred embodiments, the free sarcosine (every day absorb 0.1-1g Cortex Cinnamomi aqueous extract/5g sarcosine four time, absorb 5 day) of picked-up with Cortex Cinnamomi aqueous extract can make the about 35mmol/kg dm of total muscle sarcosine increase.
The total muscle sarcosine that those skilled in the art will appreciate that increase refers to total muscle sarcosine of the average increase in a large amount of populations of static state, and this is increased between the individuality and can changes.Particularly, having to a certain degree, the sarcosine increase of the individuality of glucagon is starkly lower than average value added.
Comprise that in picked-up after the sarcosine compositions of Cortex Cinnamomi aqueous extract, the cumulative clinical assays of sarcosine can be measured by the whole bag of tricks well known by persons skilled in the art in the skeletal muscle.For example, the accumulation of sarcosine can directly be measured by muscle biopsy in the skeletal muscle.
The cumulative direct measurement of sarcosine can comprise take out biopsy samples from object of study in the muscle.With biopsy samples preferably in freezing under the liquid nitrogen, lyophilizing and be stored under-80 ℃ to carry out metabolite analysis subsequently.Usually, with fat by with petroleum ether extraction from through freeze dried sample, removing, the tissue dissection muscle samples that never visible blood and knot are formed dusts it then.Then, can prepare the spectroscopic assay that is used for phosphoric acid sarcosine and sarcosine through neutral perchloric acid extract.Total sarcosine concentration in the muscle can be calculated by the concentration of phosphoric acid sarcosine and free sarcosine is sued for peace.
Get after the sarcosine compositions that comprises the Cortex Cinnamomi aqueous extract in absorption, can assess the accumulation of sarcosine in the skeletal muscle indirectly.Compare with the object of study of only absorbing sarcosine, the blood plasma sarcosine concentration of the object of study of the combination of picked-up sarcosine and low-calorie sarcosine compositions of the present invention and the homaluria of sarcosine obviously reduce, and this shows that whole sarcosine retentivity has increased.
Sarcosine level in the measurement blood plasma is preferably included in the picked-up supplement and took out venous blood from the back side of hands immediately in the past in later 20,40 and 60 minutes.In addition, can supplement the previous day and that day collect urine sample in picked-up.Utilize the sarcosine of high-efficient liquid phase color spectrometry blood plasma and urine sample and utilize radioimmunoassay commercial measurement serum insulin.Referring to for example United States Patent (USP) 5,968,900.
Sarcosine
As used herein, " sarcosine " refers to compound N-methyl-N-guanine glycine, CAS 57-00-1 (being also referred to as (Alpha-Methyl guanidine radicals) acetic acid), N-(amino imino methyl)-N-glycine and methyl glycocyamine and methylglycocyamine and N-methyl-N-guanine glycine, the following chemical constitution of having listed them.As used herein, " sarcosine " also comprises the derivant of sarcosine, for example ester, ethyl ester, chelate and amide and other derivant (being included in the derivant that works in the metabolic processes).The following is the chemical constitution of sarcosine:
Sarcosine
Do not wish bound by theory, think that sarcosine increases strength, muscle size and promotes cell expansion (cell volumization).
Can extensively obtain sarcosine and sarcosine derivative from shiploads of merchandise.The commercial sarcosine derivative that can get comprises sarcosine phosphate ester, sarcosine monohydrate, sarcosine lactate, carnitine sarcosine (carnitine creatinate), sarcosine fumarate, sarcosine lipoate, sarcosine arginine ester, sarcosine ethyl, anhydrous sarcosine, through encapsulated sarcosine, effervescent sarcosine, sarcosine citrate, sarcosine magnesium, alkaline sarcosine, sarcosine pyruvate, sarcosine hydrate and three sarcosine malates.Presoma also is that commerce can get and is applicable in the practice of the present invention in the body of glycocyamine and sarcosine.
As used herein, a supplement comprise the about 0.5g sarcosine of about 0.01g-/g supplement.More preferably, a supplement comprise the about 0.25g sarcosine of about 0.05g-/g supplement.Most preferably, a supplement comprise the about 0.2g sarcosine of about 0.1g-/g supplement.
In an embodiment of the invention, supplement comprise about 1.5 grams, two sarcosine malate/part.
Cinnamomic aqueous extract
As used herein, " cinnamomic aqueous extract " preferably refers to be included in the polyphenol polymer in Cortex Cinnamomi (that is various Cinnamomum the mutation) aqueous extract.More preferably, " cinnamomic aqueous extract " refers to hydroxy chalcone polymer and A type procyanidin polymer.Most preferably, the two bonding types-A procyanidolic oligomers of " cinnamomic aqueous extract " fingernail base hydroxy chalcone polymer and catechin/epicatechin.By phosphorylation that promotes Insulin receptor INSR and the dephosphorylation that passes through to suppress insulin receptor kinase, verified these extracts can trigger the insulin cascade system and strengthen the activity of insulin, thereby increase the sensitivity of insulin and stimulate the absorption of glucose and synthesizing of glycogen.
Preferably, a supplement comprise the cinnamomic aqueous extract of the about 0.5g of about 0.001g-/gram supplement.More preferably, a supplement comprise the cinnamomic aqueous extract of the about 0.3g of about 0.01g-/gram supplement.Most preferably, a supplement comprise the cinnamomic aqueous extract of the about 0.2g of about 0.02g-/gram supplement.
In an embodiment of the invention, supplement comprise about 0.025 gram Cortex Cinnamomi extract (2%MHCP)/part.
Alpha-lipoic acid
As used herein, " alpha-lipoic acid " preferably refers to chemical compound 1,2-dithiolane-3-valeric acid (CAS 62-46-4 is also referred to as thioctic acid and 6, and the 8-disulfide group is sad), following its chemical constitution of listing.As used herein, " alpha-lipoic acid " also comprises the derivant (for example ester and amide) of alpha-lipoic acid and other derivant (for example the sodium salt of thioctic acid, sarcosine lipoate, R-thioctic acid, S-thioctic acid and be included in the derivant that works in the metabolic processes).The following is the chemical constitution of alpha-lipoic acid:
Alpha-lipoic acid is a kind of insulin regulator and a kind ofly can protects it to avoid the antioxidant of oxidative damage in non-nervous tissue and nervous tissue.Alpha-lipoic acid is the nutrient that human body is made with trace, and can obtain from yeast and liver.Research shows, alpha-lipoic acid obviously increases the body utilization of blood glucose among the type ii diabetes patient and thioctic acid can be in diabetics increases by 50% with the metabolic clearance rate of glucose.In Europe, alpha-lipoic acid has been used as the succedaneum of insulin in type ii diabetes patient's treatment.
Although the present invention is not limited to by any theoretical explanation, but think that insulin is to stimulate glucose and sarcosine to be transported to the main factor in the muscle cell, and alpha-lipoic acid in being transported to the process of muscle cell, glucose and sarcosine both having imitated and had strengthened the effect of insulin.
Preferably, a supplement comprise the about 100mg alpha-lipoic acid of about 0.1mg-/gram supplement.More preferably, a supplement comprise the about 75mg alpha-lipoic acid of about 1.0mg-/gram supplement.Most preferably, a supplement comprise the about 30mg alpha-lipoic acid of about 25mg-/gram supplement.
In an embodiment of the invention, supplement comprise about 50mg alpha-lipoic acid/part.
The dosage form of supplement can provide with the form of capsule, liquid beverage, powder drink mixture or the bar shaped article that is easy to eat.The dosage form of supplement can provide according to the common process technology that is used for medical herbs, dietary supplementation agent, and wherein, active component is suitably processed and is loaded in the cellulose capsule with suitable excipient.
Other composition advantageously can be added in the supplementary, this other composition strengthens the accumulation of sarcosine in skeletal muscle.Randomly, other composition can be selected from by hydroxyl-isoleucine, chromium complex and L-taurine with and the group formed of derivant (for example ester, amide) and other derivant (being included in the derivant that works in the metabolic processes).
For optimum efficiency, supplementary preferably comprises caffeine, catechin polyphenol, other methylxanthine and its combination, and these materials further improve the absorption and the auxiliary reduction side effect of sarcosine in skeletal muscle.
Paraguay tea (Yerba Mate) can provide with the form of Ilex Paraguayensis leaf or its extracting and enriching thing.Think that gastronintestinal system is had various effects (comprise and prolong digestion period) to paraguay tea and conduct promotes the satiety composition.Preferably, a supplement comprise the about 100mg paraguay tea of about 0.1mg-.More preferably, a supplement comprise the about 50mg paraguay tea of 0.5mg-.Most preferably, a supplement comprise about 1mg paraguay tea.
Salix alba bark (Salix Alba) is a kind of aspirin source (main component of aspirin), has observed the white willow micromicro to reduce serum lipoprotein (a) (Lp (a)) (developing atherosclerotic risks and assumptions).Apolipoproteins, genetic transcription that the Salix alba bark has by reduction among those patients of high serum lipoprotein (a) are worked to Lp (a).Preferably, a supplement comprise the about 100mg Salix alba of about 0.1mg-bark.More preferably, a supplement comprise the about 50mg Salix alba of about 0.5mg-bark.Most preferably, a supplement comprise about 1mg Salix alba bark.
Huperzine (Huperzine) is a kind of acetylcholinesterase inhibitor.Think that huperzine is used for increasing the release of animal and human's body growth hormone.Preferably, a supplement comprise the about 1mg huperzine of about 0.01mg-.More preferably, a supplement comprise the about 0.2mg huperzine of about 0.02mg-.Most preferably, a supplement comprise about 0.05mg huperzine.
Preferably, caffeine and catechin polyphenol provide together with the form of the tea extract of tea, green tea or enrichment.
Preferably, a supplementary comprises that the tea extract of tea, green tea or enrichment of capacity is to provide about 25-about 1000mg caffeine.More preferably, a supplementary comprises that the tea extract of the green tea of capacity or enrichment is to provide about 50-about 300mg caffeine.Most preferably, a supplementary comprises that the tea extract of the green tea of capacity or enrichment is to provide about 300mg caffeine.
Preferably, a supplementary comprises that the tea extract of tea, green tea or enrichment of capacity is to provide the catechin polyphenol of the about 1000mg of about 1mg-.More preferably, portion comprises that the tea extract of the green tea of capacity or enrichment is to provide the catechin polyphenol of the about 500mg of about 75mg-.Most preferably, portion comprises that the tea extract of the green tea of capacity or enrichment is to provide the catechin polyphenol of about 200mg.
Replacedly, caffeine can provide with pure basically caffeine or the natural composition form that is present in other composition.The catechin polyphenol can also provide with the catechin polyphenol form of pure basically catechin polyphenol or enrichment.Catechin polyphenol pure basically or enrichment can be selected from the group of being made up of epigallocatechin gallate (EGCG), L-Epicatechin gallate, epicatechin and epigallo catechin.
Randomly, the extract of green tea with other tea (for example, oolong tea, postfermented tea or Ramulus et Folium Mussaendae Pubescentis) replenished to replenish the thermogenesis performance of independent green tea.
Randomly, green tea is replenished to replenish the thermogenesis performance of independent green tea with pure basically caffeine.
Randomly, green tea is replenished to replenish the thermogenesis performance of independent green tea with pure basically catechin polyphenol.
Supplementary preferably is used for increasing the accumulation of human skeleton flesh sarcosine for the purpose of for example building up muscle.In addition or replacedly, the present invention also provides in order for example to reduce that the body fat amount loses weight and the purpose of improving the muscle lines is used for increasing animal the method and composition of themogenesis.Preferably, described people is the athlete.
Preferably, supplement provide with capsule form.Replacedly, supplement can be with other dosage form (for example, tablet, capsule sheet or the bar-shaped product that is easy to eat).Preferably, the people takes these supplement with the water or the sports drinks of 8-16 ounce.
In one embodiment, the athlete takes a supplementary every day 1-4 time.More preferably, took supplement in one day 2 times.
In interchangeable embodiment, took a supplementary 2 times in one day, 12 hours at interval.More preferably, took a supplementary 2 times in one day, early last, after the training once.
In interchangeable embodiment, took a supplementary 2 times in one day, 12 hours at interval, wherein, take once a supplementary morning, take once before the training.
In another interchangeable embodiment, after training, irregularly take supplement every day.
In interchangeable embodiment, irregularly take supplement every morning on an empty stomach.
In interchangeable embodiment, irregularly take supplement every day in the morning and before training.
In one embodiment, the invention provides a kind of method of making supplementary, this supplementary comprises sarcosine and cinnamomic aqueous extract and can be included in other compositions, especially alpha-lipoic acid.This method comprises the steps:
A. with microcrystalline Cellulose and sarcosine and cinnamomic aqueous extract premixing;
B. add through pre-magnesium stearate and the tripoli that sieves;
C. allotment mixed 30 minutes;
D. verification uniformity/homogeneity, five equilibrium composition then.
Although following examples have been illustrated some embodiments of the present invention, these embodiment should not constitute limitation of the scope of the invention.Obviously, those skilled in the art can consider other embodiment by this description and embodiment.
Embodiment
Embodiment 1: the dietary supplementation agent
Prepare every part of dietary supplementation agent that comprises the capsule form of following composition, this dietary supplementation agent is taken by the athlete.
| Umber: three capsules | ||
| Amount 2.357g/ part prescription % of every part | ||
| Blend 1 | 1.6 | |
| Three sarcosine malates | 1.500 | 63.6389％ |
| Alpha-lipoic acid | 0.050 | 2.1213％ |
| Cinnamomum verum extract (bark) | 0.025 | 1.0606％ |
| Blend 2 | .725 | |
| Green tea extract (leaf) | 0.444 | 18.8371％ |
| Be standardized as 95% polyphenol [70% catechin (45% epigallocatechin gallate (EGCG)-175mg EGCG)] | ||
| Caffeine (Caffeine Anhydrous) | 0.250 | 10.6065％ |
| Oolong tea extract (leaf) | ||
| Be standardized as 50% polyphenol [25% catechin (15% epigallocatechin gallate (EGCG)-15mg EGCG)] | 0.010 | 0.4243％ |
| Theobromine extract (theobrome cacao) (seed) | 0.010 | 0.4243％ |
| Ramulus et Folium Mussaendae Pubescentis extract (leaf) | ||
| Be standardized as 50% polyphenol [35% catechin (10% epigallocatechin gallate (EGCG)-10mg EGCG)] | 0.010 | 0.4243％ |
| Guarana extract (seed) | 0.0010 | 0.0424％ |
| Paraguay tea extract (Ilex paraguariensis) (leaf) | 0.0010 | 0.0424％ |
| Be standardized as the 250mg caffeine | ||
| Blend 3 | .058 | |
| Fructus Evodiae extract (Tetradium ruticarpum) (fruit) | ||
| Be standardized as 10% rutaecarpin | 0.05 | 2.1213％ |
| Vinpocetine (Vinpocetine) | 0.0050 | 0.2121％ |
| Salix alba extract (bark) | 0.001 | 0.0424％ |
| Be standardized as 25% salicin | 0.001 | 0.0424％ |
| Huperzine extract (Hyperzia serrata) (moss) | 0.00005 | 0.0021％ |
| All | 2.357 | 100％ |
| Do not determine daily value | ||
| Other composition: gel, cellulose, magnesium stearate, tripoli | ||
Embodiment 2: using method
As the dietary supplementation agent, the dietary supplementation agent three times that take three embodiments 1 with 8 ounces of water individual every day, take 60 minutes ante cibum.In order to assess individual tolerance, abide by following dose form and take.
| 1 week | 1 capsule, every day 3 * |
| 2 weeks | 2 capsules, every day 3 * |
| 3 the week and more than | 3 capsules, every day 3 * |
Embodiment 3: with the dietary supplementation agent of diet and training combination
Individual with the dietary supplementation agent of defined dosage among the embodiment 2 and the diet and the training plan combination of carrying out rule of edible low-calorie.Individuality is taken these portions supplement once before training.Drink 10 glasss of 8 ounces of water the individual every day of general health.
Embodiment 4: the dietary supplementation agent
| Part | 3 capsules | ||
| Composition | 2.407g/ part | Active component g/ part | Prescription % |
| Two sarcosine malates | 1.500 | 62.3169％ | |
| Green tea cured leaf extract (45%EGGE, 75% catechin, 90% polyphenol) | 0.444 | 0.2EGCE | 18.4458％ |
| Caffeine Anhydrous | 0.300 | 12.4634％ | |
| Salix alba bark (25% salicin) | 0.001 | 0.00025 salicin | 0.0415％ |
| Alpha-lipoic acid | 0.050 | 2.0772％ |
| Cinnamon bark extract (2% MHCP) | 0.025 | 0.0005MHCP | 1.0386％ |
| Oolong tea cured leaf extract (15%EGGE, 50% polyphenol, 25% catechin) | 0.010 | 0.0015EGCG | 0.4154％ |
| Ramulus et Folium Mussaendae Pubescentis cured leaf extract (15%EGGE, 50% polyphenol, 35% catechin) | 0.010 | 0.0015EGCG | 0.4154％ |
| Theobroma cocao extract (6% theobromine) | 0.010 | 0.0006 theobromine | 0.4154％ |
| Fructus Evodiae (10% rutaecarpin) | 0.0500 | 0.005 rutaecarpin | 2.0772％ |
| Huperzine A (1% huperzine A) | 0.00005 | 0.0000005 huperzine A | 0.0021％ |
| Guarana (being standardized as 1% caffeine+21% Caffeine Anhydrous) | 0.0010 | 0.00001 caffeine+0.00021 Caffeine Anhydrous | 0.0415％ |
| The paraguay tea powder | 0.0010 | 0.0415％ | |
| Vinpocetine | 0.0050 | 0.2077％ | |
| Total amount | 2.407 | 100.0000％ |
Embodiment 5: eating method
As the dietary supplementation agent, individuality is taken supplementary illustrated among the embodiment 4 according to following method and warning:
Using method: as the dietary supplementation agent, take three capsules three time with 8 ounces of water every day, and take about 30-60 minute ante cibum.Train the same day, take 1 before the training.Drink 10 glasss of 8 ounces of water every day.Read entire description before edible also in accordance with taking.In surpassing 3 and/or 24 hours in 4 hours not above 9.Go to bed and do not take in preceding 5 hours.In order to assess individual patience, according to following table.
1 day-3 days 1 capsule, every day 3 *
4 days-7 days 2 capsules, every day 3 *
8 days and above 3 capsules, every day 3 *
For optimum, alimentation composition of the present invention (being specially alimentation composition illustrated among the embodiment 4) is combined with high pressure training and nutrition plan.
Claims (24)
1. one kind is used for increasing sarcosine and accumulates, builds up muscle, increases themogenesis, reduces the body fat quality and lose weight and improve at least a alimentation composition of muscle lines, and described alimentation composition comprises cinnamon extract and sarcosine.
2. alimentation composition as claimed in claim 1, wherein, described cinnamomic extract is the Cortex Cinnamomi aqueous extract.
3. alimentation composition as claimed in claim 1 also comprises alpha-lipoic acid.
4. alimentation composition as claimed in claim 1 wherein, provides described sarcosine with the form of two sarcosine malates.
5. alimentation composition as claimed in claim 1 also comprises one or more kinds in green tea extract (leaf), oolong tea extract (leaf), Ramulus et Folium Mussaendae Pubescentis extract (leaf), caffeine, bark of willow extract (white), Fructus Evodiae, theobromine, capsaicin, Guarana extract (seed) and the paraguay tea.
6. alimentation composition as claimed in claim 1 also comprises green tea extract (leaf), caffeine, oolong tea extract (leaf), theobromine extract, Ramulus et Folium Mussaendae Pubescentis extract (leaf), Guarana extract (seed), paraguay tea extract, Fructus Evodiae extract, vinpocetine, Salix alba extract and huperzine extract.
7. alimentation composition as claimed in claim 1 also comprises green tea cured leaf extract, caffeine, Salix alba bark, alpha lipoic acid, cinnamon bark extract, oolong tea cured leaf extract, Ramulus et Folium Mussaendae Pubescentis cured leaf extract, therobroma cocao extract, Fructus Evodiae, huperzine, Guarana, paraguay tea powder and vinpocetine.
8. alimentation composition as claimed in claim 1, wherein, described alimentation composition provides with capsular form.
9. being used for increasing sarcosine accumulates, builds up muscle, increases themogenesis, reduces the body fat quality and lose weight and improve at least a method of muscle lines, described method following steps: consume the alimentation composition that comprises cinnamon extract and sarcosine.
10. method as claimed in claim 9, wherein, described cinnamon extract is cinnamomic aqueous extract.
11. method as claimed in claim 9, wherein, described alimentation composition also comprises alpha-lipoic acid.
12. method as claimed in claim 9 wherein, provides described sarcosine with the form of two sarcosine malates.
13. method as claimed in claim 9, wherein, described alimentation composition also comprises one or more kinds in green tea extract (leaf), oolong tea extract (leaf), Ramulus et Folium Mussaendae Pubescentis extract (leaf), caffeine, bark of willow extract (white), Fructus Evodiae, theobromine, capsaicin, Guarana extract (seed) and the paraguay tea.
14. method as claimed in claim 9, wherein, described alimentation composition also comprises one or more kinds in green tea extract (leaf), caffeine, oolong tea extract (leaf), theobromine extract, Ramulus et Folium Mussaendae Pubescentis extract (leaf), Guarana extract (seed), paraguay tea extract, Fructus Evodiae extract, vinpocetine, Salix alba extract and the huperzine extract.
15. alimentation composition as claimed in claim 9, wherein, described alimentation composition also comprises one or more kinds in green tea cured leaf extract, caffeine, Salix alba bark, alpha-lipoic acid, cinnamon bark extract, oolong tea cured leaf extract, Ramulus et Folium Mussaendae Pubescentis cured leaf extract, therobroma cocao extract, Fructus Evodiae, huperzine, Guarana, paraguay tea powder and the vinpocetine.
16. method as claimed in claim 9 wherein, consumes described alimentation composition with capsular form.
A kind ofly be used for increasing sarcosine and accumulate, build up muscle, increase themogenesis, reduce the method that the body fat quality loses weight and improves at least a alimentation composition of muscle lines 17. make, described method comprises the steps:
Form the mixture of cinnamon extract and sarcosine;
Described mixture is mixed; With
With branch compositions such as described mixture.
18. method as claimed in claim 17, wherein, described cinnamon extract is cinnamomic aqueous extract.
19. method as claimed in claim 17 wherein, comprises the step of branch compositions such as described mixture described mixture is divided into capsule form.
20. method as claimed in claim 17 also comprises alpha-lipoic acid is added to step in the described mixture.
21. method as claimed in claim 17 wherein, provides described sarcosine with the form of two sarcosine malates.
22. method as claimed in claim 17 also comprises the step of adding one or more kinds in green tea extract (leaf), oolong tea extract (leaf), Ramulus et Folium Mussaendae Pubescentis extract (leaf), caffeine, bark of willow extract (white), Fructus Evodiae, theobromine, capsaicin, Guarana extract (seed) and the paraguay tea.
23. method as claimed in claim 17 also comprises the step of adding one or more kinds in green tea extract (leaf), caffeine, oolong tea extract (leaf), theobromine extract, Ramulus et Folium Mussaendae Pubescentis extract (leaf), Guarana extract (seed), Paraguay's extract, Fructus Evodiae extract, vinpocetine, Salix alba extract and the huperzine extract.
24. method as claimed in claim 17 also comprises the step of adding one or more kinds in green tea cured leaf extract (leaf), caffeine, Salix alba bark, alpha-lipoic acid, cinnamon bark extract, oolong tea cured leaf extract (leaf), Ramulus et Folium Mussaendae Pubescentis cured leaf extract, theobroma cocao extract, Fructus Evodiae, huperzine, Guarana, paraguay tea powder and the vinpocetine.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56904904P | 2004-05-07 | 2004-05-07 | |
| US60/569,049 | 2004-05-07 | ||
| US60/580,114 | 2004-06-15 |
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| CN1950073A true CN1950073A (en) | 2007-04-18 |
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| CN 200580014370 Pending CN1950073A (en) | 2004-05-07 | 2005-05-03 | Nutritional composition for increasing creatine uptake in skeletal muscle |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115385809A (en) * | 2022-07-29 | 2022-11-25 | 宁夏太康药业有限公司 | Preparation method of sarcosine magnesium chelate |
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2005
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115385809A (en) * | 2022-07-29 | 2022-11-25 | 宁夏太康药业有限公司 | Preparation method of sarcosine magnesium chelate |
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| ZA200609169B (en) | 2008-07-30 |
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