CN1943607A - Chinese medicine composition and its preparing method - Google Patents
Chinese medicine composition and its preparing method Download PDFInfo
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- CN1943607A CN1943607A CN 200510107866 CN200510107866A CN1943607A CN 1943607 A CN1943607 A CN 1943607A CN 200510107866 CN200510107866 CN 200510107866 CN 200510107866 A CN200510107866 A CN 200510107866A CN 1943607 A CN1943607 A CN 1943607A
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Abstract
A kind of compound of traditional Chinese medicine and its means of manufacturing is disclosed. Said compound consists of materials such as ginseng, grifola, tremella, etc. Said compound is mainly for curing cancer.
Description
Invention field
The present invention relates to the preparation method of a kind of Chinese medicine composition and said composition, be particularly related to a kind of syndrome of deficiency of both qi and yin tumor patient that is used for the treatment of after operation, radiotherapy, the chemotherapy, can improve symptom, leukocyte increasing improves Chinese medicine composition of immunologic function and preparation method thereof.
Background technology
In the oncotherapy, adopting tonification class Chinese medicine to carry out the body resistance strengthening and constitution consolidating is one of advantage of Chinese medicine tumor, wider to its research in recent years.Motherland's medical science thinks, tumor is many take advantage of a weak point by the weak pathogen of human righteousness due to, modern medicine confirms that human immunity state and tumor generation, development and prognosis are closely related, the theory of Chinese medicine deficiency-syndrome and modern immunologic hypofunction matches.Use tonification class Chinese medicine the body resistance strengthening and constitution consolidating, can improve the tumor patient function, from the growth of molecular level regulation and control cancerous cell, and can the direct killing cancerous cell, so use that tonification class Chinese medicine encourages healthy trends, vital base and primordial QI consolidating has its theoretical foundation as one of method of treatment tumor.
Tonic is that the main prescription of setting upright is widely used in clinical tumor, act as: treatment precancerous lesion, and prophylaxis of tumours takes place; Cooperate operation, chemicotherapy, play potentiation; The prophylaxis of tumours relapse and metastasis; Alleviate the chemicotherapy toxicity; Treatment middle and advanced stage tumor is improved symptom, improves life quality, is prolonged band tumor life span.In oncotherapy, the rational Application traditional tonic medicine can play potentiation, QI invigorating, nourish blood, YIN nourishing, medicine such as supporing yang be in the tumor of different parts, and different stressing arranged during application.The chemotherapy of tumors patient is in Chinese medical discrimination, type of deficiency of both QI and YIN is much, on Chinese medicine is selected, be main formula, as SHENGMAI YIN (Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis), MAIWEIDIHUANGWAN (Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Cortex Moutan, Poria, Rhizoma Alismatis, Radix Ophiopogonis, Fructus Schisandrae Chinensis) etc. with Qi-tonifying drug in the tonic and YIN-tonifying drug.
A large amount of clinical practice explanation, the determined curative effect of tonification class Chinese medicine in oncotherapy, especially at mitigation symptoms, improve aspect the life quality, irreplaceable effects such as chemotherapy are arranged.Therefore, performance Chinese medicine advantage is excavated the new problem that the effective cancer therapy drug of exploitation becomes current traditional Chinese medical science development, and effective component extracting is made corresponding dosage form, and it is an aspect of present Chinese medicine exploitation that expansion is promoted.As at present clinical the KANGLAITE that presses down the tumor effect is arranged, the SHENMAI ZHUSHEYE of bone marrow protective effect is arranged, the use of representative in clinical as tonic is subjected to doctor and patient's approval.Prevent and treat precancerous lesion, the prophylaxis of tumours relapse and metastasis is an emphasis of current Chinese medicine tumor research.Tonification apoplexy due to endogenous wind medical instrument has immunostimulant, tumor-inhibiting action, will hew out gratifying prospect for its extensive use in this field undoubtedly.
Summary of the invention
One object of the present invention is to provide a kind of effect with tonification vigour, YIN nourishing and the production of body fluid promoting, is used for the treatment of the syndrome of deficiency of both qi and yin tumor patient after operation, radiotherapy, the chemotherapy, can improve symptom, and leukocyte increasing improves the Chinese medicine composition of immunologic function;
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition.
The object of the present invention is achieved like this, according to the Chinese medicine and pharmacy theory, utilizes the property of medicine of medical herbs uniqueness, adopts Radix Ginseng, Poria, Polyporus, Ganoderma, Tremella according to certain compatibility requirement, processes through special process.
The crude drug of preparation pharmaceutical composition of the present invention is formed and proportioning following (by weight):
Radix Ginseng 125～375 weight portions
Poria 75～225 weight portions
Polyporus 75～225 weight portions
Ganoderma 125～375 weight portions
Tremella 100～300 weight portions
The crude drug of pharmaceutical composition of the present invention is formed best proportioning and is (by weight):
Radix Ginseng 250 weight portions
Poria 150 weight portions
Polyporus 150 weight portions
Ganoderma 250 weight portions
Tremella 200 weight portions
Medicine of the present invention can be used for a kind of in the middle of the following dosage form mixture, granule, tablet, capsule, soft capsule.
Medicine of the present invention can Radix Ginseng, Poria, Polyporus, Ganoderma, Tremella add hydro-thermal and press and extract 2～4 times, extracts 1 hour for the first time, extracts 1 hour for the second time, extracted for the third time 0.5 hour, merge extractive liquid, filters, and relative density was 1.05～1.06 clear paste when filtrate was concentrated into 80 ℃, adding ethanol makes and contains alcohol amount and reach 70%～95%, left standstill 12 hours, and filtered, get precipitation, make acceptable dosage form clinically, as: mixture, granule, tablet, capsule.
The preparation technology of medicine of the present invention can be: Radix Ginseng, Poria, Polyporus, Ganoderma, Tremella add hydro-thermal and press extraction 3 times, extracted 1 hour for the first time, extracted 1 hour for the second time, extracted merge extractive liquid, for the third time 0.5 hour, filter, relative density was 1.05～1.06 clear paste when filtrate was concentrated into 80 ℃, added ethanol and made and contain alcohol amount and reach 80%～85%, left standstill 12 hours, filter, get precipitation.
Pharmaceutical composition of the present invention is the application in the syndrome of deficiency of both qi and yin tumor after treatment operation, radiotherapy, chemotherapy mainly.
The inventor of medicine of the present invention is aspect the selection and compatibility thereof of crude drug, carried out series of experiment research, determine the crude drug composition of preparation medicine of the present invention, made it compared with prior art have significantly outstanding curative effect advantage, realized the potentiation purpose of compatible combination.
The influence experiment of S180 tumor-bearing mice humoral immune function is further specified the medical application of medicine of the present invention by administration.
Be subjected to the reagent thing: the present composition; Specification: 2g crude drug/1ml solution; Positive drug: sunrecome,
Specification: every packed 2 grams.
Animal:
The ICR white mice, 18～22g, male and female half and half are provided by animal housing of China Medicine University;
Tumor strain source:
S180 is provided by Jiangsu Province's tumour medicine institute.
Method:
Get 60 of above-mentioned specification ICR mices, (under the sterile working, get the tumor piece by transplanted tumor organon inoculation S180 solid type tumor, weigh, grind with the glass Potter-Elvehjem Tissue Grinders, put into sterile chamber after mill is even, add the cell suspension that normal saline is diluted to 1: 3, container is put on the ice cube, and with the empty needle suction, each suction is preceding with the cell mixing, every mice right fore axillary fossa subcutaneous vaccination 0.2ml), inoculate back 24 hours and claim Mus heavy, be divided into 6 groups at random by body weight, 10 every group, male and female half and half, experiment is established: normal control group (0.5%CMC-Na), and S180 lotus tumor group, the present composition is established height, in, low by (1260,630,315mg/kg, ig) three dosage groups, sunrecome group (1g/kg).Be administered once every day, administration is 10 times altogether, respectively organized mouse peritoneal injection sheep red blood cell (SRBC) 0.5ml/ (2.5%) on the 6th day in administration and carry out initial immunity, the last administration is measured and is calculated half hemolysis value HC50 and organizes a t check, the significance of comparing difference after 1 hour.
Result of the test:
The present composition to the influence of S180 tumor-bearing mice serum hemolysin (X ± S, n=10)
| Group | Dosage (mg/kg) | Body weight (g) | HC50 | |
| Normal control | Before the administration | After the administration | 207.28±27.01** | |
| 19.40±1.20 | 29.40±1.62 | |||
| S180 lotus tumor group | 19.50±1.57 | 29.80±2.14 | 132.51±35.70## | |
| The present invention's combination | 1500 | 19.60±1.11 | 29.20±2.56 | 183.70±38.49** |
| 700 | 19.30±1.10 | 29.50±2.06 | 174.29±35.65*# | |
| 300 | 19.60±1.43 | 29.50±2.87 | 159.83±41.70# | |
| Sunrecome | 1000 | 19.40±1.11 | 29.40±3.47 | 182.28±29.38** |
#P＜0.05, compare with the normal control group ##P＜0.01;
* P＜0.05, * * P＜0.01 and the comparison of S180 lotus tumor group.
The specific embodiment
Illustrate with specific embodiment more below, to the present invention without limits but following embodiment only is used to the present invention is described.
Embodiment 1:
Prescription: Radix Ginseng 250 grams
Poria 150 grams
Polyporus 150 grams
Ganoderma 250 grams
Tremella 200 grams
Method for making: Radix Ginseng, Poria, Polyporus, Ganoderma, Tremella add hydro-thermal and press extraction three times, add 10 times of water gagings for the first time and extract 1 hour, add 4 times of water gagings for the second time and extract 1 hour, add 4 times of water gagings for the third time and extracted 0.5 hour, merge extractive liquid, filters, filtrate is concentrated into the clear paste that relative density is 1.05～1.06 (80 ℃), add ethanol and make and contain alcohol amount and reach 80%～85%, left standstill 12 hours, filter, get precipitation, be dissolved in water twice, add 2 times of amounts at every turn, get supernatant, filter, add sorbic acid 2g, regulate pH value to 5.0, add water to 1000ml, stir evenly, leave standstill, filter fill.Oral, a 20ml, 2 times on the one.
Embodiment 2:
Prescription: Radix Ginseng 1000 grams
Poria 6000 grams
Polyporus 6000 grams
Ganoderma 1000 grams
Tremella 800 grams
Method for making: Radix Ginseng, Poria, Polyporus, Ganoderma, Tremella add hydro-thermal and press extraction three times, add 10 times of water gagings for the first time and extract 1 hour, add 4 times of water gagings for the second time and extract 1 hour, add 4 times of water gagings for the third time and extracted 0.5 hour, merge extractive liquid, filters, filtrate is concentrated into the clear paste that relative density is 1.05～1.06 (80 ℃), add ethanol and make and contain alcohol amount and reach 80%～85%, left standstill 12 hours, filter, get precipitation, drying adds starch to total amount, makes 1000 of capsules.Oral, one time 5,2 times on the one.
Embodiment 3:
Prescription: Radix Ginseng 1000 grams
Poria 6000 grams
Polyporus 6000 grams
Ganoderma 1000 grams
Tremella 800 grams
Method for making: Radix Ginseng, Poria, Polyporus, Ganoderma, Tremella add hydro-thermal and press extraction three times, add 10 times of water gagings for the first time and extract 1 hour, add 4 times of water gagings for the second time and extract 1 hour, add 4 times of water gagings for the third time and extracted 0.5 hour, merge extractive liquid, filters, filtrate is concentrated into the clear paste that relative density is 1.05～1.06 (80 ℃), add ethanol and make and contain alcohol amount and reach 80%～85%, left standstill 12 hours, filter, get precipitation, drying adds microcrystalline Cellulose to total amount, makes 1000 in tablet.Oral, one time 5,2 times on the one.
Embodiment 4:
Prescription: Radix Ginseng 1000 grams
Poria 6000 grams
Polyporus 6000 grams
Ganoderma 1000 grams
Tremella 800 grams
Method for making: Radix Ginseng, Poria, Polyporus, Ganoderma, Tremella add hydro-thermal and press extraction three times, add for the first time 10 times of water gagings and extracted 1 hour, add 4 times of water gagings for the second time and extracted 1 hour, add 4 times of water gagings for the third time and extracted 0.5 hour, merge extractive liquid,, filter, filtrate is concentrated into the clear paste that relative density is 1.05～1.06 (80 ℃), adds ethanol and makes and contain the alcohol amount and reach 80%～85%, left standstill 12 hours, filter, get precipitation, add dextrin and make granule 1000g.Oral, a 5g, 2 times on the one.
Embodiment 5:
Prescription: Radix Ginseng 1000 grams
Poria 6000 grams
Polyporus 6000 grams
Ganoderma 1000 grams
Tremella 800 grams
Method for making: Radix Ginseng, Poria, Polyporus, Ganoderma, Tremella adds hydro-thermal and presses extraction three times, adds 10 times of water gagings for the first time and extracts 1 hour, adds 4 times of water gagings for the second time and extracts 1 hour, add 4 times of water gagings for the third time and extracted 0.5 hour, merge extractive liquid, filters, filtrate is concentrated into the clear paste that relative density is 1.05～1.06 (80 ℃), adds ethanol and makes and contain alcohol amount and reach 80%～85%, leaves standstill 12 hours, filter, get precipitation, drying under reduced pressure, pulverize, cross 120 orders, (soybean oil is heated to 60～70 ℃, adds 4% Cera Flava in the fine powder adding substrate, stirring makes dissolves, promptly) to total amount 600g, colloid mill ground 5 minutes, the compacting soft capsule, dry, make 1000 of soft capsules, packing, promptly.Oral, one time 5,2 times on the one.
Claims (6)
1, a kind of pharmaceutical composition is characterized in that this pharmaceutical composition made by following raw material medicaments:
Radix Ginseng 125～375 weight portions
Poria 75～225 weight portions
Polyporus 75～225 weight portions
Ganoderma 125～375 weight portions
Tremella 100～300 weight portions.
2, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following raw material medicaments:
Radix Ginseng 250 weight portions
Poria 150 weight portions
Polyporus 150 weight portions
Ganoderma 250 weight portions
Tremella 200 weight portions.
3, pharmaceutical composition as claimed in claim 1 or 2 is characterized in that can be used for a kind of in the dosage forms such as mixture, granule, tablet, capsule, soft capsule.
4, as preparation of drug combination method as described in the claim 3, it is characterized in that comprising following steps:
Radix Ginseng, Poria, Polyporus, Ganoderma, Tremella extracting in water 2～4 times, merge extractive liquid,, filter, relative density was 1.05～1.06 clear paste when filtrate was concentrated into 80 ℃, added ethanol and made and contain the alcohol amount and reach 70%～95%, left standstill 12 hours, filter, get precipitation, drying, add conventional adjuvant, make required dosage form.
5, preparation of drug combination method as claimed in claim 4 is characterized in that comprising following steps:
Radix Ginseng, Poria, Polyporus, Ganoderma, Tremella add hydro-thermal and press extraction 3 times, extracted 1 hour for the first time, extracted 1 hour for the second time, extracted for the third time 0.5 hour, merge extractive liquid,, filter, relative density was 1.05～1.06 clear paste when filtrate was concentrated into 80 ℃, added ethanol and made and contain the alcohol amount and reach 80%～85%, left standstill 12 hours, filter, get precipitation, drying; Add suitable adjuvant, make required dosage form.
6, the application in the syndrome of deficiency of both qi and yin medicine of pharmaceutical composition as claimed in claim 1 or 2 after preparation is used for the treatment of tumor patient operation, radiotherapy, chemotherapy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005101078663A CN1943607B (en) | 2005-10-08 | 2005-10-08 | Chinese medicine composition for nourishing qi and yin and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005101078663A CN1943607B (en) | 2005-10-08 | 2005-10-08 | Chinese medicine composition for nourishing qi and yin and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1943607A true CN1943607A (en) | 2007-04-11 |
| CN1943607B CN1943607B (en) | 2010-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005101078663A Expired - Fee Related CN1943607B (en) | 2005-10-08 | 2005-10-08 | Chinese medicine composition for nourishing qi and yin and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857276A (en) * | 2015-05-22 | 2015-08-26 | 崔鹏 | Traditional Chinese medicine for treating both qi and yin deficiency caused by radiotherapy-chemotherapy for malignant tumor |
| CN105687886A (en) * | 2016-04-20 | 2016-06-22 | 杭州华威药业股份有限公司 | Tremella fuciformis and ganoderma mixture and method for preparing same |
| CN112425704A (en) * | 2020-11-19 | 2021-03-02 | 杭州参参慢生物科技有限公司 | Composition and health beverage containing ginseng extract |
-
2005
- 2005-10-08 CN CN2005101078663A patent/CN1943607B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857276A (en) * | 2015-05-22 | 2015-08-26 | 崔鹏 | Traditional Chinese medicine for treating both qi and yin deficiency caused by radiotherapy-chemotherapy for malignant tumor |
| CN104857276B (en) * | 2015-05-22 | 2018-07-06 | 崔鹏 | A kind of Chinese medicine for treating syndrome of deficiency of both qi and yin after malignant tumour Radiotherapy chemotherapy |
| CN105687886A (en) * | 2016-04-20 | 2016-06-22 | 杭州华威药业股份有限公司 | Tremella fuciformis and ganoderma mixture and method for preparing same |
| CN112425704A (en) * | 2020-11-19 | 2021-03-02 | 杭州参参慢生物科技有限公司 | Composition and health beverage containing ginseng extract |
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| Publication number | Publication date |
|---|---|
| CN1943607B (en) | 2010-09-22 |
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