CN1939337A - Compositions, uses and kits for treating allergic dermatitis of skin - Google Patents
Compositions, uses and kits for treating allergic dermatitis of skin Download PDFInfo
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- CN1939337A CN1939337A CN 200610153605 CN200610153605A CN1939337A CN 1939337 A CN1939337 A CN 1939337A CN 200610153605 CN200610153605 CN 200610153605 CN 200610153605 A CN200610153605 A CN 200610153605A CN 1939337 A CN1939337 A CN 1939337A
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- ethoxylate
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- laccol
- skin
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Abstract
The invention includes compositions suitable for removal of urushiol from skin having been exposed thereto, which compositions contain an ethoxylate and sodium lauroyl sarcosinate, methods for treating allergic dermatitis of skin having been exposed to urushiol, and kits suitable for treatment of allergic dermatitis.
Description
Invention field
The present invention relates to the treatment of allergic dermatitis,, and relate to the compositions that is applicable to above-mentioned treatment for example because the rhus dermatitis that contact Toxicodendron verniciflnum (Stokes) F. A. Barkley (Rhus verniciflua Stokes) oleoresin laccol causes.
Background of invention
Laccol is the toxin that causes allergic dermatitis, owing to the contact common poisonous plants if any poison ivy, poisonous robur, have the resin of the relevant plant of the black poison wood and the whole world to cause.Chemically, laccol is the catechol mixture, and 3 on catechol ring has long-chain, hydrophobic carbon (alkane) side chain.For example, poisonous Caulis Hederae Sinensis mainly contains 3-n-pentadecyl catechol (C-15), and poisonous robur mainly contains 3-n-heptadecyl catechol (C-17).
When contact skin contained the oleoresin of laccol, reaction was an allergic eczema contact dermatitis, showed as rubescent, swelling, pimple, phlycten, bulla (bullac) and cut.Treating these reactions in the past comprises removing as far as possible apace after the contact and deoils.If not in contact a period of time, for example remove in a few minutes and deoil, the follow-up toxin of removing can not successfully prevent the allergic effect reaction, though can limit its expansion.
For treatment after opening prophylactic treatment and contacting is attempted.For example, the known compositions that comprises Semen Lini oil, astringent, starch, quintessence oil and Fructus Citri Limoniae oil that adopts is treated poisonous Caulis Hederae Sinensis.Yet Semen Lini oil itself can cause skin irritation.In addition, said composition must every day puts on infected position twice and disappears up to erythra.
Other known treatment methods that is used for the treatment of the dermatitis that contact toxin laccol causes comprises: use the compositions that contains the nonyl phenenyl ethoxyl compound mixture, remove said composition to remove laccol from skin then.Yet, because the existence of nonyl phenol produces environmental effect.In addition, in this Therapeutic Method, compositions is removed within a short period of time, and need repeatedly use said composition.In addition, this treatment does not leave treatment effective active composition to continue the reaction of treatment allergic effect on skin.
A kind of compositions preferably is provided, and said composition is applicable to from skin removes laccol and environmental friendliness more.A kind of method for the treatment of allergic dermatitis of preferred development also, this method not only comprises from skin removes laccol, and is provided at the continuation treatment of removing behind the Cleasing compositions.The invention provides and be used for the environmentally acceptable compositions that skin is removed laccol, and the method and the test kit that are used for the treatment of the allergic dermatitis that the contact laccol causes.
Summary of the invention
The present invention relates to a kind of compositions, said composition is substantially free of nonyl phenenyl ethoxyl compound and is applicable to from the skin area that contacts laccol removes laccol.Described compositions comprises water, alcohol ethoxylate and sarcosyl.Alcohol ethoxylate can effectively be removed laccol from the infected skin area that contacts laccol with the relative quantity that sarcosyl exists in compositions.The invention still further relates to a kind of test kit and Therapeutic Method, described test kit comprise be applicable to from skin remove laccol first compositions and be applicable to the treatment allergic dermatitis second compositions, described Therapeutic Method comprises and uses first and second compositionss removing at least a portion laccol from the skin infected area, and the continuation treatment of removing the infected skin area of first compositions and laccol part back is provided.
According to the inventive method that is used in the skin area treatment allergic dermatitis of contact laccol, the skin area of contact laccol is contacted with first compositions, except that other optional member, first compositions also comprises the suitable carrier of alcohol ethoxylate surfactant, sarcosyl (SLS) surfactant and surfactant.Concentration that ethoxylate and SLS surfactant exist in compositions and relative quantity can effectively be removed laccol from infected skin area.
But compositions topical application or send by the method for any topical application medicine well known by persons skilled in the art, for example, lotion, spray, gel or such as the goods of wiper or liner etc.Compositions works in the wiping mode on infected area.Compositions keeps in touch skin area a period of time, effectively to remove first's laccol at least from infected skin area.Time can be from a few minutes, and for example 3 minutes, by one hour or longer, though preferably remove compositions immediately to avoid skin Long contact time laccol.Continue the enough time to guarantee for example, to remove at least a portion compositions and bonded laccol after the infected skin area composition contact compositions by cleaning skin.
Though wish to remove fully compositions and bonded laccol, according to time span and the cleaning wiping degree that infected skin area spent, may be in many cases, if not in most of the cases, by with first compositions cleaning, be not that all laccols will be removed from infected skin area.Therefore, according to the inventive method, infected skin area contacts with second compositions again, and second compositions comprises the active component that is applicable to the allergia contact-type dermatitis that the treatment laccol causes of treatment effective dose.But the second compositions topical application, or send by the method for any topical application medicine well known by persons skilled in the art, for example, lotion, spray, gel.Second compositions can be retained in infected skin area the preceding paragraph time, for example 1-24 hour.Can use second compositions more than once, so that the lasting treatment of infected area to be provided.
In some embodiments of the present invention, ethoxylate is selected from nonyl phenenyl ethoxyl compound and alcohol ethoxylate, and can comprise the mixture of nonyl phenyl and alcohol ethoxylate.Compositions can comprise two or more nonyl phenenyl ethoxyl compounds.In the gross weight of compositions, compositions can comprise the ethoxylate of about 3-40 weight % and the sarcosyl of about 2-20 weight %.The ratio of used ethoxylate and SLS depends on used specific ethoxylate.The weight ratio of ethoxylate: SLS is about 1: 2.5 to 2.5: 1 usually.
In some embodiments, compositions is substantially free of nonyl phenenyl ethoxyl compound.Be substantially free of and be meant that compositions does not include the nonyl phenenyl ethoxyl compound that helps to remove laccol or offer the concentration of compositions surface active function.Said composition comprises the nonyl phenenyl ethoxyl compound less than 10 weight %, preferably less than the nonyl phenenyl ethoxyl compound of about 5 weight %, is more preferably less than 1 weight %.Even more preferably, compositions does not contain nonyl phenenyl ethoxyl compound.Said composition comprises the alcohol ethoxylate of about 3-10 weight % and the SLS of about 2-15 weight %.Alcohol ethoxylate comprises that HLB is about the C of 9-11
9-C
15Alcohol ethoxylate.A kind of alcohol ethoxylate that uses is Brij 30, and this is that a kind of HLB is about 10 C
12Alcohol ethoxylate derives from Uniqema, is also referred to as laureth 9-4 in the CTFA/INCI nomenclature.
Compositions also comprises abrasive material, to promote removing laccol from the skin that contacts laccol.Abrasive material helps to break away from laccol and be placed on easier and ethoxylate and SLS composition position contacting compositions from skin physics.Pearl should be greatly to effectively but should be greatly to causing wearing and tearing.In some embodiments, can use the 5-50 micron, about 25 microns of mean size, or 50 purpose pearls.Compositions can comprise the abrasive material of about 5-20 weight %.Spendable abrasive material comprises polyethylene beads, as derives from Inducos 13/4 and the microwax pearl of InduChem, as derives from the Metabeads Microwax Green 28/60 of Floratech.It will be apparent to one skilled in the art that among the present invention and can use other abrasive material.
The present composition can also comprise thickening agent, chelating agen, antiseptic, softening agent, opacifier, pH buffer agent and coloring agent, and amount separately can effectively realize its functional character separately.Thickening agent comprises alkyl acrylate polymer, for example derives from the Carbopol ETD 2020 of Noveon.Chelating agen comprises sequestrene Na4.Antiseptic comprises methyl hydroxybenzoate and phenoxyethanol.The remainder of compositions comprises water.
Second compositions of using in the inventive method can be water base or non-water base.In a kind of compositions, external application analgesic medicine example hydrochloric acid pramoxine, skin conditioning agent are mixed with the aqueous solution or the alcoholic solution of ethylene glycol and film former such as isobutene ./ethyl maleimide/ethoxy maleimide copolymer as two-polypropylene glycol-2 myristyl alcohol polyethers-10 adipate ester (Di-PPG-2Myreth-10Adipate), astringent such as zinc acetate and denaturant such as the pure and mild denatonium benzoate of the tert-butyl group, the compositions of the allergic dermatitis that is applicable to that the treatment laccol causes is provided.In the gross weight of compositions, compositions can comprise about 78 weight % ethanol, about 20 weight % film former (comprising about 8% copolymer, about 5% water and about 7% alcohol), about 1 weight % external application analgesic medicine, about 0.75 weight % skin conditioning agent, about 0.12 weight % astringent and about 0.1 weight % denaturant.Also can use other compositions that contains active component that is applicable to the treatment allergic dermatitis.
The present invention also comprises the test kit that is applicable in the skin area treatment allergic dermatitis of contact laccol.This test kit comprises first compositions and second compositions, first compositions comprises above-mentioned ethoxylate and sarcosyl, its relative quantity can effectively be removed laccol from the skin area that contacts laccol, and second compositions comprises the above-mentioned active component that is applicable to the treatment allergic dermatitis of treatment effective dose.Test kit can be included in first and second compositionss in the unitary package element, or first and second compositionss are included in the individual packages element.First and second compositionss in the described test kit comprise lotion, gel or spray.Test kit also can comprise the goods that first and second compositionss put on skin, for example contains the wiper of above-mentioned any compositions.Specifically, wiper comprises a certain amount of first compositions that comprises with it, effectively removing laccol from skin, by using further wiping skin of this wiper, thereby removes laccol from skin.For example, can compositions be included in the wiper by spraying or dipping.
Provide the following examples as the present composition example and/or the inventive method and test kit in the example that uses, rather than limit the scope of claim by any way.
The specific embodiment
Embodiment 1:
Component prescription % (w/w)
Water 78.6
Glycerol 2.0
Sarcosyl 11.7
Laureth 9-4 5.0
Sequestrene Na4 0.5
DMDMH 0.9
Methyl hydroxybenzoate 0.25
Active organic principle 0.1
Citric acid (20% solution) 0.68
The standard wiper is placed the non-tight packing, and the compositions of embodiment 1 is put on the standard wiper that comprises in the packing.It is standby to seal wiper then.Compositions can be put on any wiper, liner or other applicator that are applicable to described application.
Embodiment 2:
Acrylate/C
10-30Alkyl acrylate cross-linked polymer 0.85
Diglycol stearate 1.25
Cortex cocois radicis-glucoside 0.5
Olein 0.15
Tristerin 0.15
Benzoic acid 0.025
Laureth 9-4 5.0
Sarcosyl 2.0
Dowicil 0.05
Sequestrene Na4 0.19
Sodium hydroxide 0.0005
Polyethylene 10.0
Microwax 0.19
Chromium hydroxide green (Chromium Hydroxide Green) 0.005
Tocopherol 0.0002
The water capacity
Test method:
The test position of on each forearm palmar aspect of experimenter, marking 1 cm diameter, totally four test positions.Be applied on the 0.6 cm diameter filter paper disc with the poisonous robur/poisonous Caulis Hederae Sinensis oleoresin of disposable micro charger 10 milliliters of dilutions in 1: 50.Disc is exposed to air 30 minutes, puts on four test positions carefully with tweezers then.Then, (Blenderm 3M) covers the filter paper disc that is loaded with oleoresin, is retained in the appropriate location 15 minutes with band.After 15 minutes, remove and abandon all poisonous Caulis Hederae Sinensis pasters.The fat band is applied to a position of every each forearm of experimenter, keeps after 60 seconds and remove from above-mentioned two positions.
According to standard criterion, with remaining two the test positions of the cleaning compositions of embodiment 2.With about 15 minutes of these position air dryings.Then, the fat band is applied to this two positions, keeps and remove after 60 seconds.
The fat band is placed the labelling container, then, in 500 milliliters of dehydrated alcohol, extract.Then, adopt the Flurorolog spectrophotometer, with the oleoresin in the spectrophotometric analysis ethanol sample.The result is as shown in table 1 below.
Table 1
The percentage ratio of the remaining oleoresin in sample washing back
Not contrast (not washing) 100
The compositions 5 of embodiment 1
The compositions 6 of embodiment 1 on wiper
Above-mentioned data show that the present composition can effectively be removed oleoresin from skin.
Embodiment 3: prescription % (w/w)
Ethanol 75
Isobutene ./ethyl maleimide/ethoxy maleimide copolymer 8
Pramoxine hydrochloride 1.0
Two-polypropylene glycol-2 myristyl alcohol polyethers-10 adipate ester 0.75
Zinc acetate 0.12
The tert-butyl alcohol 0.08
The water capacity
Embodiment 3 described compositionss are put on each position of experimenter of contact oleoresin, and with the described cleaning compositions of embodiment of the invention 1-3.This application will provide the continued treatment of contact oleoresin skin area.
Claims (23)
1. one kind is applicable to the compositions of removing laccol from the skin area that contacts laccol, and described compositions comprises:
Alcohol ethoxylate; With
Sarcosyl;
Described alcohol ethoxylate and described sarcosyl exist with the relative quantity of effectively removing described laccol from described skin in described compositions, and wherein, described compositions is substantially free of nonyl phenenyl ethoxyl compound.
2. compositions as claimed in claim 1, described compositions comprise the described alcohol ethoxylate of about 3-10 weight % and the described sarcosyl of about 2-15 weight % in its gross weight.
3. compositions as claimed in claim 2 is characterized in that described alcohol ethoxylate comprises the C of the about 9-11 of HLB
9-C
15Alcohol ethoxylate.
4. compositions as claimed in claim 2, described compositions comprise the described nonyl phenenyl ethoxyl compound less than about 10 weight %.
5. compositions as claimed in claim 2, described compositions comprise the described nonyl phenenyl ethoxyl compound less than 1 weight %.
6. compositions as claimed in claim 3, described compositions comprise the described C of about 5 weight %
12The described sarcosyl of alcohol ethoxylate and about 12 weight %, described compositions does not contain described nonyl phenenyl ethoxyl compound.
7. method for the treatment of the skin area allergic dermatitis said method comprising the steps of:
Can effectively remove under the condition of at least a portion laccol from described skin, the skin area that contacts laccol is contacted with first compositions that comprises ethoxylate and sarcosyl, remove described first compositions and described part laccol from described skin; With
The skin area of described exposure is contacted with second compositions, and described second compositions comprises the active component that is applicable to the treatment allergic dermatitis of treatment effective dose.
8. method as claimed in claim 7 is characterized in that described ethoxylate is selected from nonyl phenenyl ethoxyl compound and alcohol ethoxylate.
9. method as claimed in claim 8 is characterized in that, described first compositions comprises the described ethoxylate of about 3-40 weight % and the described sarcosyl of about 2-20 weight % in its gross weight.
10. method as claimed in claim 9 is characterized in that the weight ratio of described ethoxylate and described sarcosyl is about 1: 2.5 to 2.5: 1.
11. method as claimed in claim 7 is characterized in that, described active component comprises analgesic.
12. method as claimed in claim 9 is characterized in that, described active component comprises analgesic.
13. method as claimed in claim 7 is characterized in that, described ethoxylate comprises that HLB is about the C of 9-11
9-C
15Alcohol ethoxylate, wherein, described ethoxylate is substantially free of nonyl phenenyl ethoxyl compound.
14. method as claimed in claim 14 is characterized in that, described first compositions comprises the described C of about 3-10 weight % in its gross weight
9-C
15The described sarcosyl of alcohol ethoxylate and about 2-15 weight %.
15. method as claimed in claim 7 is characterized in that, described second compositions is kept and the about 1-24 of described contact skin hour.
16. method as claimed in claim 7 is characterized in that, use described second compositions once more than.
17. method as claimed in claim 7 is characterized in that, by lotion, spray, gel or wiper described first compositions is put on skin.
18. a test kit that is applicable to treatment skin area allergic dermatitis, described test kit comprises:
First compositions, it comprises ethoxylate and the sarcosyl that exists with the relative quantity of effectively removing laccol from the skin area that contacts laccol; With
Second compositions, it comprises the active component that is applicable to the treatment allergic dermatitis of treatment effective dose.
19. test kit as claimed in claim 18 is characterized in that, described ethoxylate is selected from nonyl phenenyl ethoxyl compound and alcohol ethoxylate.
20. test kit as claimed in claim 18 is characterized in that, described active component comprises analgesic.
21. test kit as claimed in claim 7 is characterized in that, described ethoxylate comprises that HLB is about the C of 9-11
9-C
15Alcohol ethoxylate, wherein, described ethoxylate is substantially free of nonyl phenenyl ethoxyl compound.
22. test kit as claimed in claim 21 is characterized in that, described active component comprises analgesic.
23. as the test kit that claim 18 is stated, described test kit comprises the goods that wherein mix described first compositions.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71564705P | 2005-09-09 | 2005-09-09 | |
| US60/715,647 | 2005-09-09 | ||
| US11/464,986 | 2006-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1939337A true CN1939337A (en) | 2007-04-04 |
Family
ID=37958039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610153605 Pending CN1939337A (en) | 2005-09-09 | 2006-09-08 | Compositions, uses and kits for treating allergic dermatitis of skin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1939337A (en) |
-
2006
- 2006-09-08 CN CN 200610153605 patent/CN1939337A/en active Pending
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| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20070404 |