CN1927578A

CN1927578A - Multilayer co-squeeze film for transfusion

Info

Publication number: CN1927578A
Application number: CN 200510037181
Authority: CN
Inventors: 李长青; 周亚君
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-09-07
Filing date: 2005-09-07
Publication date: 2007-03-14

Abstract

A multilayer common squeezed film for transfusion is composite with five layers, the first layer is high elasticity, high intensity and high obstruct special polyethylene glycol terephthalate, the second layer is ethylenemethacrylic acid copolymer, the third layer is metallocene polyethylene, the forth layer is the dibasic ethylene ethylene-propylene copolymer and the fifth layer is quick-speed heat-sealing copolymerization polypropylene which has perfect chemical stability. This invention is a five layers common squeezed casing film for transfusion which is nonhazardous, high anti-dampness, high antioxidation, high-temperature, high-transparency, good-pliability, low-temperature and good-Intensity of heat seal.

Description

Multilayer co-squeeze film for transfusion

[technical field]

The present invention relates to a kind of film, refer in particular to the thin-film material that pharmaceutically is used to pack transfusion.

[background technology]

The transfusion package major part that present China hospital uses is vial, and only a few plastic pvc packed in flexible pouchy is also arranged.Because using repeatedly from the sanitation performance of producing, being transported to before using, vial all is difficult to control, pollute the back cleaning and easily cause bacterial cross-infection, also must import air when especially infusing, and patient is more in the hospital, the pathogeny microorganism is more, air pollution is more serious, the air that imports during transfusion causes infusion reaction or cross-infection to the patient easily, the vial shape is certain in addition, volume is big, easily broken during transportation, the storage floor space is big, waits these all to increase cost to transfusion patient, therefore, be badly in need of seeking new substitute.

The soft bag of plastic pvc also exists some problems mainly to be: (1) its recipe ingredient reaches tens of kinds, component that has or even little molecule auxiliary agent, the flexible PVC plasticizer consumption is up to about 50%, the long-time storage, the surface has free micro constitutent to separate out, mix with soup, easy heat production source reflection when soup injects human body, long-term accumulated is more serious to human body harm.(2) the soft bag of PVC hear resistance is relatively poor, and sterilisation temp can only be controlled at 109 ℃, and temperature raises soft bag again and produces distortion, has limited the scope of application, can not reach aseptic assurance requirement (F ₀＜8) (the sterilization standard of China's pharmacopeia defined).(3) the PVC soft-packing transfusion storage life only is 3 months.

[summary of the invention]

The objective of the invention is, be to overcome the deficiencies in the prior art, provide that a kind of nontoxic, high resistant is wet, high resistant oxygen, high temperature resistant, height is transparent, pliability good, low temperature resistivity is strong and heat sealing strength is high environment-friendly type five-layer coextrusion transfusion packaging film.

In order to solve the technical problem of above-mentioned existence, the present invention adopts following technical proposals:

A kind of multilayer co-squeeze film for transfusion, it is characterized in that being composited by five layers, be successively ground floor be the extraordinary PETG of high resiliency, high strength and high-barrier, the second layer be dimethyl allene acid copolymer, the 3rd layer for metallocene PE, the 4th layer be the splendid high speed heat-sealing type COPP of chemical stability for binary second third COPP and layer 5.

Aforesaid multilayer co-squeeze film for transfusion, it is characterized in that: the extraordinary PETG of described high resiliency, high strength and high-barrier accounts for 15-18%, this dimethacrylate copolymer comprised 8-12%, this metallocene PE accounts for 25-30%, and this binary second third COPP accounts for 20-25% and the splendid high speed heat-sealing type COPP of chemical stability accounts for 20-20%.

1., five-layer coextrusion transfusion all is non-polar polymeric material with film formulation, do not have precipitate, has good biologically inert compared with prior art, the invention has the beneficial effects as follows:, can not react with liquid in the bag; 2., sterilisation temp can reach 121 ℃, do not produce distortion, the scope of application is extensive, guarantees aseptic requirement (F ₀＞8); 3., the transfusion flexible bag made with film of five-layer coextrusion transfusion has self-constriction, needn't import air during transfusion and just can infuse, and avoided this link bacterial cross-infection thereby enter soup without any unclean air; 4., five-layer coextrusion transfusion with the production process of film from raw pellets to the system film, cut, cannedly all in hundred grades of clean by laminar flow environment, carry out, guaranteed to greatest extent product sanitation performance, because transfusion flexible bag elasticity that five-layer coextrusion transfusion is made with film and pliability puncture the intensity height well, anti-, are not afraid of mechanical force, not cracky, volume is little and floor space is little, so all reduced many expenses at aspects such as transport and storage; 6., have higher heat seal strength, be suitable for the above transfusion package material of 500ml, and other Dispoable medical packaging material; 7., five-layer coextrusion transfusion is long with film or soft bag storage life, can reach and preserve 3 years.

The present invention is described in further detail below in conjunction with accompanying drawing and the specific embodiment:

[description of drawings]

Fig. 1 is a structural representation of the present invention;

Fig. 2 is a process chart of the present invention.

[specific embodiment]

The present invention is a film for transfusion, and it is composited by five floor height molecular materials, is successively: ground floor is the extraordinary PETG 1 of high resiliency, high strength and high-barrier; The second layer is a dimethyl allene acid copolymer 2; The 3rd layer is metallocene PE 3; The 4th layer is binary second third COPP 4; Layer 5 is the splendid high speed heat-sealing type COPP 5 of chemical stability.

Used head was the processing technology difference according to the various resins of product, designed different the designing of temperature when production was of the present invention, the characteristics of head are that each runner all has the thermal insulation barrier layer, and handpiece structure is a most advanced world taper superposing type composite machine head.

Principle of the present invention is: any macromolecular material all can not have the desired multiple performance characteristics of product simultaneously concurrently, only take special structure design and unique technical recipe design, form the best sandwich that intersects, make full use of the characteristics that each layer film has, make the material of each layer bring into play its function separately, and have advantage to concentrate in together the difference that various material possessed, take complementary method to reach utility function.The present invention is on the basis of the multiple macromolecular material character of choose reasonable, technical requirement according to multilayer co-squeeze film for transfusion, according to the close compatibility principle of macromolecular material and the structure-activity relationship of macromolecular material, respectively it is carried out modification and composite molding, study of the influence of high molecular melt crystallization speed to the material aggregated structure, design and synthesize the agent of nontoxic multifunctional macromolecule material modification and the nucleator that are fit to the various functions of this project, improve the laminated film transparency, reduce turbidity, improve the bonding force between barrier property and pliability and layer and the layer.Composite principle according to multilayer complex films, give full play to the advantage of each layer film, prepare combination property and function of use the incomparable composite membrane of single thin film is all arranged, composite forming technology solves the resistance to elevated temperatures of final products emphatically, has improved mechanical strength and the heat sealing strength and the anti-drop of product.Make full use of the inertia of non-polar polymeric material simultaneously, improve the chemical stability of multilayer co-squeeze film for transfusion internal layer.Its structure function is designed to: the top layer is to have tough and tensile protective value, good hot weld envelope effect and barriers function layer; Internal layer is high temperature resistant function and extraordinary stable chemical performance layer, guarantees that product does not have any aspirate, can any reaction not take place with soup; The intermediate layer has high barrier property and good toughening functions layer, increases the pliability of product; All the other are two-layer to be compound enhancement layer, well compound between assurance gas producing formation and the layer, and lamination does not take place.In order to form multilayer intersection composite construction effectively, be to adopt each runner reasonable in design that the superposing type composite machine head of thermal insulation barrier layer is all arranged on equipment, and the advanced molding technology thereof of employing downward-blowing water-cooling, make the multilayer co-squeeze film for transfusion of producing have high-barrier, high temperature resistant, transparent and have performances such as fine elasticity and toughness, broken through the interactional shortcoming of temperature between traditional flow channel.

The applicant adopts state-of-the-art in the world metallocene PE macromolecular material and has multiple difference in functionality modified polypropene (PP) material and extraordinary polyethylene terephthalate's macromolecular material, study of the influence of high molecular melt crystallization speed to the aggregated structure of material, design and synthesize the agent of nontoxic multifunctional macromolecule material modification and the nucleator that are fit to this project, through blending and modifying, by the multi-layer co-extruded blowing head that designs voluntarily with heat insulating function, adopt the downward-blowing water-cooling extrusion equipment, online vanguard technology of cutting and technology, produce have nontoxic, high resistant is wet, high resistant oxygen, high temperature resistant, high transparent, pliability is good, the environment-friendly type infusion pharmaceutical pack material that low temperature resistivity strong (40 ℃) and heat sealing strength are high (being called for short the five-layer coextrusion transfusion new packaging materials).Replace China and prolonging the traditional glass infusion bottle and the minority plastic pvc transfusion flexible bag of usefulness in decades always, fill up the blank of domestic this technology.Promote the technological progress of domestic and international pharmaceuticals industry, promote the optimization and upgrading of conventional industries.

The present invention adopts solubility parameter binary second third COPP and the dimethyl allene acid copolymer close with PP, make itself and polypropylene produce the combined strength bination that certain affinity increases multilayer co-squeeze film for transfusion by graft copolymerization, its production method (technological process) as shown in Figure 2.

Component ratio of the present invention is basically by following cooperation: the extraordinary PETG 1 of the high resiliency of ground floor, high strength and high-barrier accounts for 15-18%; The dimethyl allene acid copolymer 2 of the second layer accounts for 8-12%; The 3rd layer metallocene PE 3 accounts for 25-30%; The 4th layer binary second third COPP 4 accounts for 20-25%; The splendid high speed heat-sealing type COPP 5 of the chemical stability of layer 5 accounts for 20-25%.

Claims

1, a kind of multilayer co-squeeze film for transfusion, it is characterized in that being composited by five layers, be successively ground floor be the extraordinary PETG (1) of high resiliency, high strength and high-barrier, the second layer be dimethyl allene acid copolymer (2), the 3rd layer for metallocene PE (3), the 4th layer be the splendid high speed heat-sealing type COPP (5) of chemical stability for binary second third COPP (4) and layer 5.

2, multilayer co-squeeze film for transfusion according to claim 1, it is characterized in that: the extraordinary PETG of described high resiliency, high strength and high-barrier (1) accounts for 15-18%, this dimethyl allene acid copolymer (2) accounts for 8-12%, this metallocene PE (3) accounts for 25-30%, and this binary second third COPP (4) accounts for 20-25% and the splendid high speed heat-sealing type COPP (5) of chemical stability accounts for 20-20%.