CN1927220A - Montmorillonite gelling preparation for treating diarrhea and gastritis and its preparation process - Google Patents
Montmorillonite gelling preparation for treating diarrhea and gastritis and its preparation process Download PDFInfo
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- CN1927220A CN1927220A CN 200610037180 CN200610037180A CN1927220A CN 1927220 A CN1927220 A CN 1927220A CN 200610037180 CN200610037180 CN 200610037180 CN 200610037180 A CN200610037180 A CN 200610037180A CN 1927220 A CN1927220 A CN 1927220A
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Abstract
The invention relates to a montmorillonite gel agent for treating loose bowel movement and gastritis, and relative production. Wherein, said gel agnet is formed by 180-220 deals of montmorillonite, 0.15-150 deals of corrigents, 0.1-5 deals of conservatives and 640-810 deals of deionized waters, to be dispersed by ultrasonic wave, to form uniform gel. And the production comprises that (1) weighting montmorillonite, corrigents, conservatives and deionized waters; (2) adding montmorillonite into deionized water to be mixed uniformly, then adding corrigents, conservatives, to be mixed for 20min or 2 hours; (3) treating the uniform mixture with ultrasonic wave into uniform gel; (4) disinfecting and packing the gel. The inventive gel agent has simple application and better effect.
Description
Technical field
The present invention relates to a kind of medicine, refer in particular to a kind of montmorillonite gelling preparation that is used for the treatment of diarrhoea and gastritis, the invention still further relates to the preparation method of this gel preparation.
Background technology
Montmorillonitum is the multiple structure that the octahedra aluminium oxide of a kind of two four sides silicon oxide list is formed, and molecular formula is Si
8Al
4O
20(OH)
4, its powder size reaches 1～3 μ m.Discover, Montmorillonitum has high stationkeeping ability, behind medicine and mouth of a river clothes, Montmorillonitum forms gel on the gastrointestinal cavity surface, covers whole gastrointestinal cavity surface equably, form barrier, and kept 6 hours, the adsorbable multiple pathogen of Montmorillonitum is fixed in the gastrointestinal cavity surface, then excrete, thereby avoid enterocyte to be damaged by pathogen with enterokinesia.Montmorillonitum also has fixation to colitoxin, staphylotoxin and cholera toxin, reduces the enterocyte movement disorder simultaneously, recovers the normal rhythm of enterokinesia, safeguards the conveying and the absorption function of intestinal.In addition, Montmorillonitum can also alleviate the mucosal tissue pathological changes due to the campylobacter jejuni, repairs the intercellular bridge of damaging, and cell is closely connected, and prevents that pathogen from entering blood circulation, and suppresses its breeding.On the other hand; the Montmorillonitum enterocyte rate of transformation that can slow down; promote the absorption function of enterocyte; reduce its secretion; Montmorillonitum can pass through and the intermolecular interaction of casing slime; increase cohesiveness, mucosa elasticity and the life period of mucus gel; thereby enhancing mucus barrier; protection gastrointestinal cell top and intercellular bridge are avoided damaging; the digestion mucous membrane there is very strong covering power; and by mutually combining, from quality and quantity two aspect reparations, improve the defense function of mucosa barrier to attack factor with mucous glycoprotein.
At present, clinically with the Montmorillonitum acute and chronic diarrheal determined curative effect of treatment that looses, but in use also have following deficiency: (1) because of the proportion of Montmorillonitum powder greater than water, can not with the abundant mixing of water, easily sedimentation can not form gel at stomach, enteral very soon after oral, thereby onset is slow; (2) concerning the infant patient, the mouthfeel of powder is poor, take difficulty.
Summary of the invention
The objective of the invention is above-mentioned deficiency, a kind of taking convenience, the rapid-action montmorillonite gelling preparation that is used for the treatment of diarrhoea and gastritis are provided at prior art.
Another object of the present invention provides a kind of method for preparing above-mentioned montmorillonite gelling preparation.
Last purpose of the present invention is achieved in that a kind of montmorillonite gelling preparation that is used for the treatment of diarrhoea and gastritis, it is characterized in that described umber is a weight portion by 180～220 parts of Montmorillonitums, 0.15～150 part of correctives, 0.1～5 portion of antiseptic and 640～810 parts of even gels that deionized water is handled through ultrasonic dispersing.
The above-mentioned montmorillonite gelling preparation that is used for the treatment of diarrhoea and gastritis is characterized in that described correctives is wherein a kind of or its combination of sodium chloride, glucose, sucrose, aspartame, stevioside, vanillin.
The above-mentioned montmorillonite gelling preparation that is used for the treatment of diarrhoea and gastritis is characterized in that described antiseptic is the wherein a kind of of benzoic acid, sodium benzoate, parabens.
Back of the present invention one purpose is achieved in that a kind of preparation method that is used for the treatment of the montmorillonite gelling preparation of diarrhoea and gastritis, comprises the steps: that (1) takes by weighing Montmorillonitum, correctives, antiseptic and deionized water respectively by formula ratio; (2) it is even earlier Montmorillonitum to be added deionized water for stirring, adds correctives, antiseptic then, continues to stir 20 minutes～2 hours; (3) again the mixed liquor that stirs is become even gel with ultrasonic Treatment under stirring condition; (4) fill is promptly after sterilizing for gel.
Ultrasonic frequency is 15KHz～100KHz in the step in the above-mentioned preparation method (3), and hyperacoustic jitter time is according to hyperacoustic intensity size, and the time is 5 minutes～2.5 hours, is as the criterion to form even gel.
Boiling sterilization is adopted in sterilization described in the step in the above-mentioned preparation method (4), and boiling time is 10～120 minutes.
The present invention compared with prior art has following advantage:
(1) the present invention is according to the mechanism of action of Montmorillonitum, earlier Montmorillonitum and deionized water are prepared into gel under the ultrasound wave effect, make that Montmorillonitum is evenly distributed at solution, granularity is thinner, absorption affinity is stronger, can be dispersed in the human intestines and stomach surface fast after taking, effect rapidly.
(2) gel preparation is taken more conveniently than powder, need not use mixing in water for oral taking.
(3) by adding an amount of correctives, make the mouthfeel of gel preparation good, be particularly suitable for children taking at gel.
The specific embodiment
Below in conjunction with specific embodiment the present invention is described in further detail, but does not constitute any limitation of the invention.
Embodiment 1
Montmorillonite gelling agent prescription: montmorillonite 2 00g, sodium chloride 2.0g, glucose 60g, aspartame 1.0g, vanillin 0.3g, sodium benzoate 2g, deionized water 735g.
Preparation method:
(1) it is standby to take by weighing raw material, the adjuvant of formula ratio;
(2) it is even Montmorillonitum to be added deionized water for stirring, adds sodium chloride, glucose, aspartame, vanillin and sodium benzoate then, continues to stir to carry out abundant swelling in 30 minutes;
(3) again the mixed liquor that stirs is become even gel with ultrasonic Treatment under stirring; Ultrasonic frequency 32KHz, 20 minutes processing times;
(4) then gel is boiled sterilization in 10 minutes, cooling back fill becomes 1g/ bag (in the content of Montmorillonitum).
Embodiment 2
Montmorillonite gelling agent prescription: Montmorillonitum 180g, sodium chloride 2.0g, glucose 56g, vanillin 0.3g, sodium benzoate 2g, deionized water 640g.
Preparation method:
(1) it is standby to take by weighing raw material, the adjuvant of formula ratio;
(2) it is even Montmorillonitum to be added deionized water for stirring, adds sodium chloride, glucose, vanillin and sodium benzoate then, continues to stir to carry out abundant swelling in 30 minutes;
(3) again the mixed liquor that stirs is become even gel with ultrasonic Treatment under stirring; Ultrasonic frequency 32KHz, 30 minutes processing times;
(4) then gel is boiled sterilization in 30 minutes, cooling back fill becomes 3g/ bag (in the content of Montmorillonitum).
Embodiment 3
Montmorillonite gelling agent prescription: montmorillonite 2 10g, glucose 56g, vanillin 0.3g, benzoic acid 2g, deionized water 700g.
Preparation method:
(1) it is standby to take by weighing raw material, the adjuvant of formula ratio;
(2) it is even Montmorillonitum to be added deionized water for stirring, adds glucose, vanillin and benzoic acid then, continues to stir to carry out abundant swelling in 30 minutes;
(3) again the mixed liquor that stirs is become even gel with ultrasonic Treatment under stirring; Ultrasonic frequency 30KHz, 60 minutes processing times;
(4) then gel is boiled sterilization in 60 minutes, cooling back fill becomes 3g/ bag (in the content of Montmorillonitum).
Embodiment 4
Montmorillonite gelling agent prescription: montmorillonite 2 20g, sodium chloride 2.0g, glucose 100g, aspartame 0.3g, vanillin 0.3g, methyl hydroxybenzoate 1g, deionized water 795g.
Preparation method:
(1) it is standby to take by weighing raw material, the adjuvant of formula ratio;
(2) it is even Montmorillonitum to be added deionized water for stirring, adds sodium chloride, glucose, aspartame, vanillin and methyl hydroxybenzoate then, continues to stir to carry out abundant swelling in 30 minutes;
(3) again the mixed liquor that stirs is become even gel with ultrasonic Treatment under stirring; Ultrasonic frequency 30KHz, 60 minutes processing times;
(4) then gel is boiled sterilization in 60 minutes, cooling back fill becomes 1g/ bag (in the content of Montmorillonitum).
Embodiment 5
Montmorillonite gelling agent prescription: Montmorillonitum 180g, aspartame 0.15g, sodium benzoate 2g, deionized water 640g.
Preparation method:
(1) it is standby to take by weighing raw material, the adjuvant of formula ratio;
(2) it is even Montmorillonitum to be added deionized water for stirring, adds aspartame, sodium benzoate then, continues to stir to carry out abundant swelling in 30 minutes;
(3) again the mixed liquor that stirs is become even gel with ultrasonic Treatment under stirring; Ultrasonic frequency 32KHz, 20 minutes processing times;
(4) then gel is boiled sterilization in 60 minutes, cooling back fill becomes 3g/ bag (in the content of Montmorillonitum).
Embodiment 6
Montmorillonite gelling agent prescription: montmorillonite 2 10g, sodium chloride 2.0g, sucrose 30g, vanillin 0.3g, ethyl hydroxybenzoate 1g, deionized water 767.
(1) it is standby to take by weighing raw material, the adjuvant of formula ratio;
(2) it is even Montmorillonitum to be added deionized water for stirring, adds sodium chloride, sucrose, vanillin and ethyl hydroxybenzoate then, continues to stir to carry out abundant swelling in 30 minutes;
(3) again the mixed liquor that stirs is become even gel with ultrasonic Treatment under stirring; Ultrasonic frequency 30KHz, 60 minutes processing times;
(4) then gel is boiled sterilization in 60 minutes, cooling back fill becomes 3g/ bag (in the content of Montmorillonitum).
Embodiment 7
Montmorillonite gelling agent prescription: montmorillonite 2 20g, sodium chloride 2.0g, glucose 148g, sodium benzoate 2g, deionized water 810g.
(1) it is standby to take by weighing raw material, the adjuvant of formula ratio;
(2) it is even Montmorillonitum to be added deionized water for stirring, adds sodium chloride, glucose, sodium benzoate then, continues to stir to carry out abundant swelling in 30 minutes;
(3) again the mixed liquor that stirs is become even gel with ultrasonic Treatment under stirring; Ultrasonic frequency 30KHz, 60 minutes processing times;
(4) then gel is boiled sterilization in 120 minutes, cooling back fill becomes 1g/ bag (in the content of Montmorillonitum).
Experimental example
In order to estimate montmorillonite gelling treatment diarrheal effect, to comparing treatment with Montmorillonitum powder at random through 42 example diarrhoea aspiration patients (age: 9 years old～56 years old), 22 examples are organized in the gel treatment, 20 examples are organized in the powder treatment, instructions of taking is by the effective content of Montmorillonitum: child 1g/ time, every day 3 times; Be grown up every day 3 times 3g/ time.The result is: montmorillonite gel treatment group produce effects 21 examples, and effective 1 example, average cure time is 1.75 ± 0.25 days; Montmorillonitum powder treatment group produce effects 19 examples, effective 1 example, average cure time is 2.32 ± 0.25 days, through finding that relatively the montmorillonite gelling effect is rapider than powder.
Claims (6)
1. one kind is used for the treatment of the diarrhoea and the montmorillonite gelling preparation of gastritis, it is characterized in that described umber is a weight portion by 180～220 parts of Montmorillonitums, 0.15～150 part of correctives, 0.1～5 portion of antiseptic and 640～810 parts of even gels that deionized water is handled through ultrasonic dispersing.
2. the montmorillonite gelling preparation that is used for the treatment of diarrhoea and gastritis according to claim 1 is characterized in that described correctives is the wherein one or more combination of sodium chloride, glucose, sucrose, aspartame, stevioside, vanillin.
3. the diarrhoea and the montmorillonite gelling preparation of gastritis of being used for the treatment of according to claim 1 is characterized in that described antiseptic is the wherein a kind of of benzoic acid, sodium benzoate, parabens.
4. the described preparation method that is used for the treatment of the montmorillonite gelling preparation of diarrhoea and gastritis of claim 1 is characterized in that comprising the steps: that (1) takes by weighing Montmorillonitum, correctives, antiseptic and deionized water respectively by formula ratio; (2) it is even earlier Montmorillonitum to be added deionized water for stirring, adds correctives, antiseptic then, continues to stir 20 minutes～2 hours; (3) again the mixed liquor that stirs is become even gel with ultrasonic Treatment under stirring condition; (4) fill is promptly after sterilizing for gel.
5. preparation method according to claim 4 is characterized in that ultrasonic frequency is 15KHz～100KHz in the step (3), 5 minutes～2.5 hours time.
6. preparation method according to claim 4 is characterized in that the sterilization employing boiling sterilization described in the step (4), and boiling time is 10～120 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610037180A CN1927220B (en) | 2006-08-24 | 2006-08-24 | Montmorillonite gelling preparation for treating diarrhea and gastritis and its preparation process |
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|---|---|---|---|
| CN200610037180A CN1927220B (en) | 2006-08-24 | 2006-08-24 | Montmorillonite gelling preparation for treating diarrhea and gastritis and its preparation process |
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| CN1927220A true CN1927220A (en) | 2007-03-14 |
| CN1927220B CN1927220B (en) | 2010-05-12 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112387B (en) * | 2007-08-06 | 2011-04-13 | 南京白敬宇制药有限责任公司 | Smectite turbid liquor for treating non-infectious diarrhea and method for preparing the same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100340235C (en) * | 2004-05-21 | 2007-10-03 | 山东绿叶制药有限公司 | Montmorillonite dispersed tablet and preparation technique thereof |
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2006
- 2006-08-24 CN CN200610037180A patent/CN1927220B/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112387B (en) * | 2007-08-06 | 2011-04-13 | 南京白敬宇制药有限责任公司 | Smectite turbid liquor for treating non-infectious diarrhea and method for preparing the same |
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| CN1927220B (en) | 2010-05-12 |
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