CN1924556A - Optical path system for clinical test analyzer - Google Patents
Optical path system for clinical test analyzer Download PDFInfo
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- CN1924556A CN1924556A CN 200510036986 CN200510036986A CN1924556A CN 1924556 A CN1924556 A CN 1924556A CN 200510036986 CN200510036986 CN 200510036986 CN 200510036986 A CN200510036986 A CN 200510036986A CN 1924556 A CN1924556 A CN 1924556A
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Abstract
This invention relates to one clinical test analyzer light path system and especially to semi-conductor light element as clinical test analyzer light source analyzer. The light path systems comprises light elements, focuses lens, sample pool and detector and is characterized by the calibration of the light element through focus lens by semiconductor Led and go into the sample pool by parallel light. The said sample pool is loaded with object to be tested.
Description
Technical field
The present invention relates to a kind of light path system of clinical inspection analytic instrument, particularly relate to the clinical inspection analytic instrument of semiconductor light-emitting elements as the check light source of clinical inspection analytic instrument.
Background technology
Optical Analysis Method is as one of detection means the most frequently used in the clinical examination analysis, wherein photoelectric colorimetry and spectrophotometric method are the most outstanding, have been widely used in the multiple medical analysis instrument, as Biochemical Analyzer, microplate reader, the mensuration of haemoglobin and the analyzing and testing of chromatogram.The speciality that colourimetry and spectrophotometric method are based on different molecular structures absorbs the selectivity of electromagnetic radiation and the analytical approach set up, belongs to the molecular absorption spectrum analysis.Molecular absorption spectrum is relevant with the structure of material itself, and the size of absorbance is relevant with the content of speciality, utilizes the shape of absorption spectrum and the size of degree of absorption, can carry out qualitative and quantitative analysis to material.This qualitative and quantitative analysis is according to lambert-Beer law.Design corresponding light path system according to lambert-Beer law, this light path system requires comparatively strict in function aspects.At first, the monochromaticity of light is generally described the monochromaticity of light with half-wave bandwidth (FWHM).When if only complex light or half-wave bandwidth are big relatively, will cause lambert-Beer law linearity to depart from.The half-wave bandwidth of general interference filter is 8nm, and spectrophotometric half-wave bandwidth is then about 2nm, even littler, and they can both satisfy the monochromaticity requirement of clinical examination instrument to light.Secondly, stability of light source.Generally require light source luminous intensity maintenance in a long time good stable.The 3rd, multi-wavelength is provided with function, because specific material only just has good absorption characteristic to specific wavelength, therefore requires instrument to have multi-wavelength that function is set, in order to the detection of different material.The general analysis instrument is provided with 4 to 8 monochromatic light checking functions, and the spectrum span is from 340nm to 700nm.
The light path system of traditional instrument is by halogen light source, and several parts such as interference filter (prism or grating), sample chamber, detecting device, signal amplification and output demonstration are formed.Tradition check light source has following shortcoming.
1, conventional light source belongs to thermal light source, the luminescent spectrum broad, and from the ultraviolet light to the infrared light (250nm-2500nm), wherein infrared and some are visible/ultraviolet light waves are not utilized, and are radiated or are absorbed.
2, light source stability is relatively poor.
3, the response time is long.For stabilized light source, need the start waiting time of a few minutes.
4, light source life is short, and is easily aging.About 2000 hours of the life-span of Halogen lamp LED, to use to be prone to after a period of time agingly, the light intensity deficiency influences measuring accuracy.
5, requiring in some monochromaticity to wavelength is not under the very strict situation, uses optical filter or grating, and cost is higher.
6, optical filter is prone to aging; Grating monochromator then cost is too high, and assembling is inconvenient.
At the deficiency of above-mentioned conventional light path, the present invention proposes the scheme of semiconductor light-emitting elements as clinical analysis instrument light source, to guarantee to improve stability, the reliability of light path system.
Summary of the invention
Light path system of the present invention comprises light-emitting component, condenser, and sample cell and detector is characterized in that semiconductor Led light-emitting component collimates through condenser, and incide sample cell with directional light, dress testee in the described sample cell.
The employing of condenser of the present invention cooperates with pinhole filter and produces the collimation parallel beam, and described pinhole filter places between described semiconductor Led light-emitting component and the condenser.Described pinhole filter is positioned at the focal plane of condenser, and the clear aperature value of pinhole filter is less than Φ 1mm, and by the fixing pinhole filter of card post and light source shelf threaded engagement.
The clear aperature value of pinhole filter of the present invention is preferably Φ 0.8mm.
Led of the present invention can form a module, this module and other external module threaded engagement with pinhole filter, condenser.Described pinhole filter is positioned at the focal plane of condenser, guarantees that the directional light of collimation enters sample cell, reduces the influence and interchannel mutual interference mutually of veiling glare.When the spectral width of described Led is big, can use with the interference filter coupling, interference filter is used to produce the monochromatic light of 8nm half-wave bandwidth.Optical filter is pushed down by trim ring and light source shelf threaded engagement, the internal orifice dimension of trim ring is φ 5mm, the restriction clear aperature, temperature sensor and Peltier and corresponding electronic circuit are formed the temperature detection control section, proofread and correct the environment temperature of Led, light source shelf curved surface and other module threaded engagement, the fixed light source frame.
Be provided with the detector condenser between detector of the present invention and the sample cell, described sample cell is used to adorn testee, and flow colorimetric pond and cuvette are arranged.
The Led luminescence chip that the present invention is different is encapsulated on the disk, and the diameter of disk is controlled in the φ 10mm, and the interval of adjacent chips is less than 0.5mm; adopt epoxy encapsulation; the protection chip, the luminous visual angle of chip is in ± 30 °, by the Push And Release of IC selective control chip.
The present invention compared with prior art has the following advantages.
1, light source is more energy-conservation, and the life-span is long;
2, instrument performance is more stable, and is reliable;
3, in the higher occasion of some accuracy requirements, can be used, have characteristics such as space structure is little, assembling is easy with optical filter;
4, start is stablized waiting time and is reduced greatly;
5, can be by the Push And Release of software control light source, sparkling control.
Description of drawings
Fig. 1 a, Fig. 1 b are the optical principle synoptic diagram of pinhole filter that the present invention adopts.
Fig. 2 is a light path system principle schematic of the present invention.
Fig. 3 is a multicore sheet Led light-source structure synoptic diagram of the present invention.
Fig. 4 is a single channel structure explosive view of the present invention.
Fig. 5 is a multi-channel structure explosive view of the present invention.
Fig. 6 is the three-dimensional wiring layout of Fig. 5.
Embodiment
The present invention is described in further detail below in conjunction with description of drawings: as Fig. 1 a, 1b, 2,4, the present invention includes semiconductor light-emitting elements (Led) 1, and condenser 4,6, sample cell 5 and detector 7 also comprise pinhole filter 2 and interference filter 8 sometimes.The Led model and the number that are adopted are decided according to concrete condition.4 couples of Led of condenser collimate, and guarantee that directional light is mapped to sample cell 5, also improve light intensity simultaneously.
Because chip and the encapsulating structure characteristics of led, led will be luminous with certain dispersion angle, and as Fig. 1, if simply adopt condenser 4 to collimate, outgoing beam will be light beam broad, that contain oblique parallel emergent ray so, and hot spot is bigger.For multichannel light path, this will cause the mutual interference of interchannel phase, influence interchannel consistance.Therefore in order to obtain tiny collimated light beam, adopt pinhole filter 2 to cooperate and produce the collimation parallel beam with condenser 4.
The light path system synoptic diagram as shown in Figure 2, this system is by Led 1, pinhole filter 2, condenser 4, sample cell 5, detector condenser 5 and detector 7 are formed, this light path system does not contain beam splitters such as optical filter or grating.Sample cell 5 is used to adorn testee, and flow colorimetric pond and cuvette are arranged.Pinhole filter 2 is positioned at the focal plane of condenser 4, guarantees that the directional light of collimation enters sample cell 5, reduces the influence and interchannel mutual interference mutually of veiling glare.When the spectral width of Led is big, can use with interference filter 14 couplings, to improve testing accuracy.Interference filter 14 is used to produce the monochromatic light of 8nm half-wave bandwidth.In a word, adopt Led to replace traditional halogen light source.
Led is as monochromatic source: when predominant wavelength below ultraviolet light, Led itself can be used as a monochromatic source, for example predominant wavelength is the Led of 405nm, its half-wave bandwidth is about 20nm; And predominant wavelength is that (see nichia corporation product type: NSHU590B), the half-wave bandwidth is about 12nm for the Led of 365nm.Therefore the monochromaticity of wavelength being required is not under the very strict situation, forms light path system and traditional light path system has a very big difference by this Led, does not promptly need beam splitters such as optical filter or grating.
Led itself has the little characteristics of space structure, can form a module with pinhole filter 2, condenser 4.This module and other external module threaded engagement, the space structure of simplification light path system is convenient to debugging and is installed.When light path when being single pass, this module is made up of Led, Led light source shelf 8, card post 9, pinhole filter 2 and condenser 4, and concrete structure is seen shown in the accompanying drawing 1.Card post 10 and light source shelf 8 threaded engagement are pinhole filter 2 fixedly, and pinhole filter 2 is positioned at the focal plane of condenser 4.The clear aperature value of pinhole filter 2 is got φ 0.8mm here less than φ 1mm.
Led has response soon, and the characteristics that luminescence chip is little can encapsulate different luminescence chips together, by the Push And Release of IC selective control chip.As shown in Figure 3, the Chip Packaging of nine different glow colors on a disk 13.The diameter of disk 13 is controlled in the φ 10mm, and the interval of adjacent chips is less than 0.5mm.Adopt epoxy encapsulation, the protection chip.
The luminous visual angle of chip is in ± 30 °.A miniature interference filter is respectively arranged before each chip, and the peak wavelength of interference filter is positioned near the peak wavelength of chip, and interference filter half-wave bandwidth is 8nm, controls the monochromaticity of light by it.Realize that by multi-way switch Led lights or closes.
The whole optical path system will be made up of multicore sheet Led light-source structure, sample cell and detector etc. this moment.It is little that such system has a space structure, do not have the filter wheel rotating mechanism, characteristics such as the wavelength switch speed is fast.
Curved surface 11 and other outer member threaded engagement of accompanying drawing 4, fixed L ed light source shelf.
Make the delustring screw thread at the light hole 12 of led light source shelf in addition and handle, eliminate veiling glare.The characteristics of this module are that the space is little, easy and other module (as the sample cell module) assembling.
When multi-channel detection, concrete structure such as accompanying drawing 5, shown in Figure 6.Accompanying drawing 5, Fig. 6 are 8 passage light path systems.The fit system of each element is with the single channel light source module.
Concrete structure is seen accompanying drawing 5.This module is by Led light source shelf 8, and pinhole filter 2 blocks post 9, temperature sensor, and Peltier refrigerator and Led form.Card post 9 and light source threaded engagement are pushed down optical filter.The internal orifice dimension of trim ring is φ 5mm, the restriction clear aperature.Settle temperature sensor and Peltier in addition in Led light source shelf 8, external relevant temperature detects control section, proofreaies and correct the Led environment temperature.Light source shelf curved surface 1 and other module threaded engagement, the fixed light source frame is convenient to the debugging assembling.
The general analysis instrument has a plurality of wavelength to select to use for the user, and for example Biochemical Analyzer has monochromatic light such as 340nm, 405nm, 500nm, 546nm, 578nm, 620nm, 670nm.As previously described, ultraviolet Led half-wave bandwidth is less, about 16nm; The half-wave bandwidth of visible light Led is then bigger, more than the 40nm.Therefore adopting Led at present is how to realize a plurality of monochromatic light as the light source greatest difficulty of analytical instrument, selects in order to the user.
Claims (10)
1. the light path system of a clinical inspection analytic instrument comprises light-emitting component, condenser, and sample cell and detector is characterized in that semiconductor Led light-emitting component collimates through condenser, and incide sample cell with directional light, dress testee in the described sample cell.
2. the light path system of clinical inspection analytic instrument according to claim 1, the employing that it is characterized in that described condenser cooperates with pinhole filter and produces the collimation parallel beam, and described pinhole filter places between described semiconductor Led light-emitting component and the condenser.
3. the light path system of clinical inspection analytic instrument according to claim 2, it is characterized in that described pinhole filter is positioned at the focal plane of condenser, the clear aperature value of pinhole filter is less than Φ 1mm, and by the fixing pinhole filter of card post and light source shelf threaded engagement.
4. the light path system of clinical inspection analytic instrument according to claim 3, the clear aperature value that it is characterized in that described pinhole filter is Φ 0.8mm.
5. according to the light path system of claim 3 or 4 described clinical inspection analytic instruments, it is characterized in that described Led can form a module, this module and other external module threaded engagement with pinhole filter, condenser.
6. the light path system of clinical inspection analytic instrument according to claim 5 is characterized in that described pinhole filter is positioned at the focal plane of condenser, guarantees that the directional light of collimation enters sample cell, reduces the influence and interchannel mutual interference mutually of veiling glare.
7. the light path system of clinical inspection analytic instrument according to claim 6 when it is characterized in that the spectral width of described Led is big, can use with the interference filter coupling, and interference filter is used to produce the monochromatic light of 8nm half-wave bandwidth.
8. the light path system of clinical inspection analytic instrument according to claim 7, it is characterized in that optical filter pushed down by trim ring and light source threaded engagement, the internal orifice dimension of trim ring is φ 5mm, the restriction clear aperature, temperature sensor and Peltier and corresponding electronic circuit are formed the temperature detection control section, proofread and correct the environment temperature of Led, light source shelf curved surface and other module threaded engagement, fixed light source frame.
9. the light path system of clinical inspection analytic instrument according to claim 1 is characterized in that being provided with the detector condenser between described detector and the sample cell, and described sample cell is used to adorn testee, and flow colorimetric pond and cuvette are arranged.
10. the light path system of clinical inspection analytic instrument according to claim 1; it is characterized in that different Led luminescence chips is encapsulated on the disk; the diameter of disk is controlled in the φ 10mm; the interval of adjacent chips is less than 0.5mm; adopt epoxy encapsulation; the protection chip, the luminous visual angle of chip is in ± 30 °, by the Push And Release of IC selective control chip.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510036986 CN1924556A (en) | 2005-08-29 | 2005-08-29 | Optical path system for clinical test analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510036986 CN1924556A (en) | 2005-08-29 | 2005-08-29 | Optical path system for clinical test analyzer |
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| CN1924556A true CN1924556A (en) | 2007-03-07 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102175805A (en) * | 2010-12-31 | 2011-09-07 | 大连依利特分析仪器有限公司 | Fixed wavelength detector for liquid chromatograph |
| CN103091307A (en) * | 2011-10-31 | 2013-05-08 | 深圳迈瑞生物医疗电子股份有限公司 | Photoelectric detection component and sample analyzer |
| CN103323395A (en) * | 2013-06-27 | 2013-09-25 | 中国科学院苏州生物医学工程技术研究所 | Single-light-source multi-channel optical system applied to flow analyzer |
| CN104146698A (en) * | 2014-08-19 | 2014-11-19 | 王卫东 | Device for detecting blood volume and tissue metabolism abnormalities |
| CN104833747A (en) * | 2015-05-06 | 2015-08-12 | 华东理工大学 | Ultraviolet detector for preparing color spectrum employing deep-ultraviolet LED light source |
| CN105911270A (en) * | 2016-04-12 | 2016-08-31 | 成都恩普生医疗科技有限公司 | Enzyme-linked immunometric meter |
| CN112305741A (en) * | 2020-05-27 | 2021-02-02 | 南方科技大学 | Multi-focus optical system |
-
2005
- 2005-08-29 CN CN 200510036986 patent/CN1924556A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102175805A (en) * | 2010-12-31 | 2011-09-07 | 大连依利特分析仪器有限公司 | Fixed wavelength detector for liquid chromatograph |
| CN103091307A (en) * | 2011-10-31 | 2013-05-08 | 深圳迈瑞生物医疗电子股份有限公司 | Photoelectric detection component and sample analyzer |
| CN103323395A (en) * | 2013-06-27 | 2013-09-25 | 中国科学院苏州生物医学工程技术研究所 | Single-light-source multi-channel optical system applied to flow analyzer |
| CN104146698A (en) * | 2014-08-19 | 2014-11-19 | 王卫东 | Device for detecting blood volume and tissue metabolism abnormalities |
| CN104146698B (en) * | 2014-08-19 | 2016-03-09 | 王卫东 | For detecting the device of blood flow volume and tissue metabolism's exception |
| CN104833747A (en) * | 2015-05-06 | 2015-08-12 | 华东理工大学 | Ultraviolet detector for preparing color spectrum employing deep-ultraviolet LED light source |
| CN105911270A (en) * | 2016-04-12 | 2016-08-31 | 成都恩普生医疗科技有限公司 | Enzyme-linked immunometric meter |
| CN112305741A (en) * | 2020-05-27 | 2021-02-02 | 南方科技大学 | Multi-focus optical system |
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