CN1903357A - Liver hydrolytic peptide for injection and prepn. method therefor - Google Patents
Liver hydrolytic peptide for injection and prepn. method therefor Download PDFInfo
- Publication number
- CN1903357A CN1903357A CNA2005100319268A CN200510031926A CN1903357A CN 1903357 A CN1903357 A CN 1903357A CN A2005100319268 A CNA2005100319268 A CN A2005100319268A CN 200510031926 A CN200510031926 A CN 200510031926A CN 1903357 A CN1903357 A CN 1903357A
- Authority
- CN
- China
- Prior art keywords
- liver
- hydrolyzed peptide
- injection
- solution
- hydrolyzed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 11
- 210000004185 liver Anatomy 0.000 title claims description 66
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 55
- 238000002347 injection Methods 0.000 title claims description 20
- 239000007924 injection Substances 0.000 title claims description 20
- 230000003301 hydrolyzing effect Effects 0.000 title 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims description 23
- 239000000243 solution Substances 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000011550 stock solution Substances 0.000 claims description 12
- 238000004108 freeze drying Methods 0.000 claims description 11
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 8
- 241000283690 Bos taurus Species 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- 229930195725 Mannitol Natural products 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 235000010355 mannitol Nutrition 0.000 claims description 6
- 239000000594 mannitol Substances 0.000 claims description 6
- 230000007062 hydrolysis Effects 0.000 claims description 5
- 238000006460 hydrolysis reaction Methods 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 238000005070 sampling Methods 0.000 claims description 5
- 239000002158 endotoxin Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 239000011265 semifinished product Substances 0.000 claims description 4
- JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 claims description 3
- 108010019160 Pancreatin Proteins 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 238000005520 cutting process Methods 0.000 claims description 3
- 210000003195 fascia Anatomy 0.000 claims description 3
- 238000011010 flushing procedure Methods 0.000 claims description 3
- 238000007710 freezing Methods 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims description 3
- 210000000232 gallbladder Anatomy 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000012982 microporous membrane Substances 0.000 claims description 3
- 229940055695 pancreatin Drugs 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- 239000008227 sterile water for injection Substances 0.000 claims description 3
- 238000000859 sublimation Methods 0.000 claims description 3
- 230000008022 sublimation Effects 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 239000008215 water for injection Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 238000012423 maintenance Methods 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- 230000002440 hepatic effect Effects 0.000 abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 238000011835 investigation Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 210000003494 hepatocyte Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 239000000413 hydrolysate Substances 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 208000000419 Chronic Hepatitis B Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 description 1
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 101800001530 Thymosin alpha Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 206010019692 hepatic necrosis Diseases 0.000 description 1
- 230000007866 hepatic necrosis Effects 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 210000003935 rough endoplasmic reticulum Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
Images
Landscapes
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Dissolubility | Dissolubility is good | Dissolubility is good | Dissolubility is good |
Acidity | 7.02 | 6.86 | 6.80 |
The investigation condition | The investigation time (my god) | Investigation project and result | |||||
Character | Clarity | High molecular weight material | Acid-base value | Loss on drying (%) | Contain labelled amount polypeptide (%) | ||
Illumination | 0 | The off-white color block that loosens | Up to specification | Up to specification | 6.78 | 2.31 | 100.70 |
5 | The off-white color block that loosens | Up to specification | Up to specification | 6.80 | 2.36 | 100.34 | |
10 | The off-white color block that loosens | Up to specification | Up to specification | 6.75 | 2.34 | 100.25 | |
High humidity | 0 | The off-white color block that loosens | Up to specification | Up to specification | 6.78 | 2.31 | 100.70 |
5 | The off-white color block that loosens | Up to specification | Up to specification | 6.77 | 2.27 | 100.67 | |
10 | The off-white color block that loosens | Up to specification | Up to specification | 6.73 | 2.25 | 100.92 | |
High temperature (60 ℃) | 0 | The off-white color block that loosens | Up to specification | Up to specification | 6.78 | 2.31 | 100.70 |
5 | The off-white color block that loosens | Up to specification | Up to specification | 6.76 | 2.32 | 100.18 | |
10 | The off-white color block that loosens | Up to specification | Up to specification | 6.76 | 2.29 | 100.09 |
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2005100319268A CN1903357B (en) | 2005-07-27 | 2005-07-27 | Liver hydrolytic peptide for injection and preparation method therefor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2005100319268A CN1903357B (en) | 2005-07-27 | 2005-07-27 | Liver hydrolytic peptide for injection and preparation method therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1903357A true CN1903357A (en) | 2007-01-31 |
CN1903357B CN1903357B (en) | 2011-09-14 |
Family
ID=37672819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005100319268A Expired - Fee Related CN1903357B (en) | 2005-07-27 | 2005-07-27 | Liver hydrolytic peptide for injection and preparation method therefor |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1903357B (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102228676A (en) * | 2011-07-07 | 2011-11-02 | 白求恩医科大学制药厂 | Heparolysate injection pharmaceutical composition |
CN102294013A (en) * | 2011-09-08 | 2011-12-28 | 中国人民解放军第四五八医院 | Hepatocyte growth-promoting factor and preparation and application thereof |
CN102294014A (en) * | 2011-09-08 | 2011-12-28 | 中国人民解放军第四五八医院 | Hepatocyte growth-promoting factor and preparation and application thereof |
CN102764423A (en) * | 2012-08-20 | 2012-11-07 | 湖北济生医药有限公司 | Polypeptide drug composition obtained through hydrolysis of animal livers and preparation method thereof |
CN103190557A (en) * | 2013-04-16 | 2013-07-10 | 缪为民 | Novel compound nutritional product with liver damage repairing efficacy |
CN103301217A (en) * | 2013-06-05 | 2013-09-18 | 周天琼 | Composition and applications thereof, pharmaceutical preparation and health-care product |
CN109549955A (en) * | 2019-01-04 | 2019-04-02 | 湖南海济药业有限公司 | A kind of preparation method of cattle liver extracting solution |
CN109568261A (en) * | 2019-01-04 | 2019-04-05 | 湖南海济药业有限公司 | A kind of polypeptide oral liquor and preparation method thereof of prevention and alleviation chemical damage |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU706088A1 (en) * | 1978-07-07 | 1979-12-30 | Всесоюзный научно-исследовательский институт технологии кровезаменителей и гормональных препаратов | Method of obtaining hog liver hydrolisate |
-
2005
- 2005-07-27 CN CN2005100319268A patent/CN1903357B/en not_active Expired - Fee Related
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102228676A (en) * | 2011-07-07 | 2011-11-02 | 白求恩医科大学制药厂 | Heparolysate injection pharmaceutical composition |
CN102294013A (en) * | 2011-09-08 | 2011-12-28 | 中国人民解放军第四五八医院 | Hepatocyte growth-promoting factor and preparation and application thereof |
CN102294014A (en) * | 2011-09-08 | 2011-12-28 | 中国人民解放军第四五八医院 | Hepatocyte growth-promoting factor and preparation and application thereof |
CN102294013B (en) * | 2011-09-08 | 2014-01-29 | 中国人民解放军第四五八医院 | Hepatocyte growth-promoting factor and application thereof |
CN102764423A (en) * | 2012-08-20 | 2012-11-07 | 湖北济生医药有限公司 | Polypeptide drug composition obtained through hydrolysis of animal livers and preparation method thereof |
CN103190557A (en) * | 2013-04-16 | 2013-07-10 | 缪为民 | Novel compound nutritional product with liver damage repairing efficacy |
CN103301217A (en) * | 2013-06-05 | 2013-09-18 | 周天琼 | Composition and applications thereof, pharmaceutical preparation and health-care product |
CN109549955A (en) * | 2019-01-04 | 2019-04-02 | 湖南海济药业有限公司 | A kind of preparation method of cattle liver extracting solution |
CN109568261A (en) * | 2019-01-04 | 2019-04-05 | 湖南海济药业有限公司 | A kind of polypeptide oral liquor and preparation method thereof of prevention and alleviation chemical damage |
Also Published As
Publication number | Publication date |
---|---|
CN1903357B (en) | 2011-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: HUNAN WUZHOUTONG PHARMACEUTICAL Co.,Ltd. Assignor: Wuhan Tongyuan Pharmaceutical Co.,Ltd. Contract record no.: 2012430000030 Denomination of invention: Liver hydrolytic peptide for injection and prepn. method therefor Granted publication date: 20110914 License type: Exclusive License Open date: 20070131 Record date: 20120416 |
|
TR01 | Transfer of patent right |
Effective date of registration: 20171220 Address after: 432800 Xiaogan City, Hubei Province town of Chengguan Dawu County Han market No. 135 Patentee after: HUBEI KANGCHENG HUIHAI MEDICINE TECHNOLOGY CO.,LTD. Address before: 430071 Hubei Province, Wuhan city Wuchang District Road No. 100 purple Patentee before: Wuhan Tongyuan Pharmaceutical Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20181123 Address after: 432500 8 Heping Road, Yunmeng Economic Development Zone, Xiaogan, Hubei Patentee after: HUBEI MERRYCLIN PHARMACEUTICAL Co.,Ltd. Address before: 432800 135, Han Da market, Chengguan Town, Dawu County, Xiaogan, Hubei Patentee before: HUBEI KANGCHENG HUIHAI MEDICINE TECHNOLOGY CO.,LTD. |
|
TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110914 Termination date: 20210727 |