CN1899592A - Wanhua oil Babu plaster for traumatic injury and preparing method - Google Patents
Wanhua oil Babu plaster for traumatic injury and preparing method Download PDFInfo
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- CN1899592A CN1899592A CN 200610036467 CN200610036467A CN1899592A CN 1899592 A CN1899592 A CN 1899592A CN 200610036467 CN200610036467 CN 200610036467 CN 200610036467 A CN200610036467 A CN 200610036467A CN 1899592 A CN1899592 A CN 1899592A
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Abstract
The present invention relates to medicine, and is Wanhua oil cataplasma for traumatic injury and its preparation process. Each 100 sq cm of the Wanhua oil cataplasma contains medicine ointment in 5-15g; and each 100g of the medicine ointment contains effective medicine components in 0.5-15.0g and water 40-60g except hydrophilic matrix. The hydrophilic matrix consists of crosslinking polyacrylate resin, sodium acrylate and glycerin in certain weight proportion. The effective medicine components consist of liposoluble extract prepared with 77 kinds of medicinal materials and through supercritical CO2 extraction, peppermint oil, turpentine, camphor oil, oleum eucalypti, and other materials. The supercritical CO2 extraction can raise the utilization rate of Chinese medicinal materials and raise curative effect.
Description
Technical field
The present invention relates to field of medicaments, being specifically related to the plant is the novel form and preparation method thereof of DIEDA WANHUAYOU of raw material.
Background technology
DIEDA WANHUAYOU is recorded in " the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation " the 18, make by 86 flavor Chinese crude drugs such as Fructus Cnidii, Rhizoma Chuanxiong, Cortex Moutan, Radix Et Rhizoma Rhei, has hemostasis and pain-relieving, dephlogistication and promoting nuscle growth, detumescence dissipating blood stasis, the relaxing muscles and tendons and activating QI and blood in the collateral effect, be mainly used in the treatment traumatic injury clinically, bump is sprained, and knife injury is hemorrhage, scald etc., evident in efficacy.This product is an external preparation.But former dosage form is a liniment, and preparation technology is simple, just uses the vegetable oil hot dipping after 13 days merely Chinese crude drug, abandons medicinal residues, and packing forms, and extracts active ingredients is incomplete, and extraction ratio is not high, and shortcomings such as using inconvenient, easy pollution clothes is arranged.In order to inherit and excavate traditional Chinese patent medicine, improve the international competitiveness of product, be necessary to improve the dosage form and the preparation method of original DIEDA WANHUAYOU, especially improve the extraction process of original Chinese crude drug.
Summary of the invention
The objective of the invention is to be made into a kind of novel formulation-cataplasma, and the preparation method of this cataplasma is provided with the prescription of original DIEDA WANHUAYOU.
Conventional cataplasma is made up of back lining materials, medicinal part and substrate composed plaster and coverlay, and to achieve the object of the present invention, the technical scheme that is adopted is every 100cm
2Cataplasma be coated with adhesive plaster 5～15g, contain medicinal position 0.5～15.0g in the 100g plaster, moisture 40～60g, surplus is hydrophilic matrix.
Said hydrophilic matrix is made up of following weight portion raw material:
1.0～5.0 parts of crosslinked polypropylene acid resins
2.0～10.0 parts of sodium polyacrylate
18.0～30.0 parts of glycerol
Said medicinal part is to be made by following 86 flavor raw materials:
[prescription]
Flos Chrysanthemi Indici 288g Radix Linderae 75g Flos Cleistocalycis Operculati 188g
Radix Cynanchi Paniculati 75g Bulbus Allii 150g Herba Portulacae 75g
Herba Alii fistulosi 150g leaf of Flos Lonicerae 75g Caulis Kadsurae Coccineae 150g
Radix Clematidis 75g Cortex Gossampini 75g TUXIXIN 75g
Flos puerariae lobatae 138g Herba Polycarpaeae Corymbosae 75g Caulis Tinosporae 100g
Fructus Cnidii 75g Radix berchemiae lineatae 100g Radix achyranthis asperae (Herba Achyranthis Asperae) 75g
Lignum Sappan 100g Radix Et Rhizoma Rhei 75g Inula cappa (Ham.) DC. 100g
Radix Ardisiae Crenatae 75g Herba Jussiaeae Repentis 100g Herba Pileae Scriptae 75g
Herba Hyperici Japonici 100g Herba Duchesneae Indicae 75g Radix Zanthoxyli 100g
Herba Lycopi 75g Flos Carthami 100g Flos Eriocauli 75g
Rhizoma Stahlianthi Involucrati 100g Flos Bombacis Malabarici 138g Herba artemisiae lactiflorae 75g
Radix Saposhnikoviae 75g Cacumen Platycladi 75g Semen Strychni 75g
Balsamiferou Blumea Herb 75g Flos Mume 75g Herba Ecliptae 50g
JIUCENGTA 50g Ramulus Salicis Babylonicae 50g Fructus Gardeniae 50g
Semen Ricini 50g rhizoma sparganic (system) 50g Herba polygoni hydropiperis 50g
Rhizoma Curcumae (system) 50g Semen Hydnocarpi (core) 50g Folium Nelumbinis 50g
Herba Selaginellae 50g Fructus Viticis 50g Fructus Gleditsia 44g
Radix Angelicae Dahuricae 44g Rhizoma Drynariae 25g Semen Persicae 25g
Cortex Moutan 25g Rhizoma Chuanxiong (system) 25g Exocarpium Citri Grandis 25g
Pericarpium Citri Reticulatae Viride 25g Pericarpium Citri Reticulatae 25g Pseudobulbus Bletillae (Rhizoma Bletillae) 25g
Rhizoma Coptidis 25g Radix Paeoniae Rubra 25g Pollen Typhae 25g
Fructus Xanthii 25g Arisaema Cum Bile 18.8g Lacca 18.8g
Radix orixae japonicae 12.5g Rhizoma Cyperi (system) 12.5g Semen Myristicae 12.5g
Fructus Amomi 12.5g Radix Arnebiae (Radix Lithospermi) 12.5g Rhizoma Et Radix Notopterygii 12.5g
Semen Alpiniae Katsumadai 12.5g Radix Angelicae Pubescentis 12.5g Rhizoma Zingiberis 12.5g
Fructus Piperis Longi 12.5g Resina Liquidambaris 100g Borneolum Syntheticum 120g
Oleum menthae 200g Oleum Terebinthinae 180g methyl salicylate 120g
Oleum Camphora 100g Oleum Eucalypti 75g Oleum Ocimi Gratissimi 52.8g
Oleum Anisi Stellati 50g Oleum Cinnamomi 5g
Get recipe quantity Flos Chrysanthemi Indici to 77 flavor Chinese crude drugs of Resina Liquidambaris liposoluble extract and Oleum menthae, Oleum Terebinthinae, Oleum Camphora, Oleum Eucalypti, Oleum Ocimi Gratissimi, Oleum Anisi Stellati, Oleum Cinnamomi and methyl salicylate beyond the 77 flavor Chinese crude drugs and the medicinal part of Borneolum Syntheticum posterior portion composition of carbon dioxide supercritical fluid extraction method extraction separation.
The extract of said 77 flavor Chinese crude drugs, be not limited to the fat-soluble extract of above-mentioned carbon dioxide supercritical fluid extraction Fa Tide, can also be used in carbon dioxide supercritical fluid extraction separate medicinal residues behind the fat-soluble extract continue with the decocting cooking method of routine extract water solubility extract, this two-part extract mixing is got mixed extract, also can get Chinese crude drug and prepare extract with conventional alcohol heat reflux extraction method.
In order to improve the performance of hydrophilic matrix, in crosslinked polypropylene acid resin, sodium polyacrylate, glycerol, can increase citric acid, aluminum chloride, by crosslinked polypropylene acid resin and sodium polyacrylate is the binding agent of substrate, the crosslinked polypropylene acid resin easily disperses in water, under the trivalent aluminium ion effect, increase rapidly with the crosslinked back of sodium polyacrylate viscosity, citric acid and aluminium ion reaction form the ring-type complex, can regulate the crosslinked intensity of binding agent, therefore, citric acid and aluminum chloride are cross-linking regulator, and glycerol is wetting agent.Once with the index of reflection cataplasma key property---initial bonding strength, hold viscous force and the percutaneous rate constant serve as to investigate index, the experimental technique of employing uniform Design is studied the amount of each component of substrate.The result shows: the use amount of crosslinked polypropylene acid resin (carbomer), sodium polyacrylate and glycerol is remarkable to the influence of three indexs, determines the molding of cataplasma to a great extent.According to result of study, crosslinked polypropylene acid resin (carbomer), sodium polyacrylate and glycerol are in following ratio range, and this cataplasma is all plastic, initial bonding strength, hold viscous force and three indexs of percutaneous rate constant all meet the requirements.
The substrate of forming with following weight portion raw material gets final product:
1.0～5.0 parts of crosslinked polypropylene acid resins
2.0～10.0 parts of sodium polyacrylate
18.0～30.0 parts of glycerol
Consider the crosslinking rate of substrate, it is good filtering out following substrate by experiment, promptly is made up of following weight portion raw material:
1.0～5.0 parts of crosslinked polypropylene acid resins
2.0～10.0 parts of sodium polyacrylate
18.0～30.0 parts of glycerol
0.15 part of citric acid
0.1 part of aluminum chloride
For reaching another object of the present invention, the preparation method of Wanhua oil Babu plaster for traumatic injury provided by the present invention, carry out as follows: one, is employing carbon dioxide supercritical fluid extraction method with Flos Chrysanthemi Indici to 77 flavor Chinese crude drugs of Resina Liquidambaris with the method for extracting effective site by recipe quantity, by recipe quantity Flos Chrysanthemi Indici to 77 flavor Chinese crude drugs of Resina Liquidambaris are thrown in the carbon dioxide supercritical fluid extraction still, at extracting pressure 15-40Mpa, separating pressure 3-8MPa, extraction temperature 30-60 ℃, separation temperature 30-40 ℃, extraction 1-5h separation obtains fat-soluble extract under the condition of flow 26.0-32.0Kg/h;
Two, press recipe quantity with Oleum menthae, Oleum Terebinthinae, Oleum Camphora, Oleum Eucalypti, Oleum Ocimi Gratissimi, Oleum Anisi Stellati, seven kinds of volatile oil mix homogeneously of Oleum Cinnamomi, methyl salicylate and the Borneolum Syntheticum of getting recipe quantity are dissolved in the mixed even mixture that gets of mixed volatilization oil, and be standby;
Three, get the extract that the first step makes, adding second mixture that goes on foot mixed is medicinal part evenly;
Four, the preparation of substrate
1. the crosslinked polypropylene acid resin is sprinkling upon in the deionized water, treated after the polymer moistening dispersion liquid stirring at low speed 30 minutes, as the A phase,
2. under stirring at low speed, sodium polyacrylate disperseed with glycerol in, and be stirred to and be uniformly dispersed, as the B phase,
3. stir down A is added to B mutually in, it is even to continue to be stirred to mastic, gets final product;
The preparation method of preferred substrate is as follows:
1. crosslinked polypropylene acid resin (carbomer) is sprinkling upon in the deionized water, treated after the polymer moistening dispersion liquid stirring at low speed 30 minutes, as the A phase,
2. citric acid and aluminum chloride are dissolved respectively, and mix and to obtain a clear solution, as the B phase,
3. under stirring at low speed, sodium polyacrylate disperseed with glycerol in, and be stirred to and be uniformly dispersed, as the C phase,
4. under stirring at low speed, B is added to C mutually in,
5. under stirring A is added in the mixture of B, C phase, it is even to continue to be stirred to mastic, gets final product;
Five, the preparation of cataplasma
Under stirring medicinal part is added in the substrate, and continue to be stirred to dispersion of medicine, coat on the suitable back lining materials, drying, the covering protection material gets final product.
Beneficial effect of the present invention: 1. make the big compound recipe oiliness of former Chinese medicine liniment into cataplasma, overcome former dosage form and used drawbacks such as inconvenient, easy pollution clothes and non-easy cleaning; 2, make the vegetable oil extracting technology into supercritical CO 2 extraction technology, not only improved the leaching rate of effective ingredient, reduced the waste of Chinese material medicine resource, improved the preparation curative effect.
Prove beneficial effect of the present invention below by pharmacodynamics test:
Former DIEDA WANHUAYOU and 77 flavor Chinese crude drugs compare with the drug effect of the medicinal part drug effect of carbon dioxide supercritical fluid extraction Fa Tide
The carbon dioxide supercritical fluid extraction method all adopts identical process conditions: extract 2h under the condition of extracting pressure 30Mpa, separating pressure 5MPa, 50 ℃ of extraction temperature, 40 ℃ of separation temperatures, flow 30.0Kg/h, done 10 batches of extracts altogether, the results are shown in following table:
Table 1
| Sample number into spectrum | Inventory (g) | Extractum amount quantities received (g) |
| 1 | 7120 | 298.8 |
| 2 | 6950 | 284.7 |
| 3 | 6800 | 314.2 |
| 4 | 7100 | 297.0 |
| 5 | 7050 | 314.3 |
| 6 | 7000 | 300.1 |
| 7 | 6990 | 308.2 |
| 8 | 7000 | 320.1 |
| 9 | 6950 | 324.8 |
| 10 | 6950 | 331.3 |
1. the preparation of drug effect sample (each sample is equivalent to the 1.507g medical material)
Method: get extract, add back volatile oil nine down by prescription and distinguish the flavor of with the suitable medical material amount of former 10 * 10ml of technology WANHUAYOU finished product, add again vegetable oil to 90.21g (weight of 10 * 10ml WANHUAYOU) as sample.
Sample 1:
Get the sample mix of 10 batches of tests, get the extract of proportional quantities, volatile oil nine flavors and the vegetable oil that add under the back in the prescription ratio are sample 1 to 90.21g
Sample 2:
Get the sample C07034 of former technology finished product, the finished product of getting proportional quantities is a sample 2
Sample 3:
Used with batch vegetable oil during the extraction of sample C07034 of getting former technology finished product, that gets proportional quantities is sample 3
2. the result of pharmacodynamics test
Table 2 different process sample xylol causes the influence of mice auricle swelling
| Group | Number of animals (only) | Auricle swelling degree (mg) X ± SD | Suppression ratio (%) |
| Sample 3 samples 2 samples 1 | 15 15 15 | 12.5±4.1 9.0±3.9 * 6.8±3.8 ** | -- 28.0 45.6 |
*P＜0.05，**P＜0.01
The result of the test of pesticide effectiveness shows, it is that the Mus auricle edema has the obvious suppression effect that ten batches of oil preparation xylol that are mixed and made into the medicinal part of carbon dioxide supercritical fluid extraction Fa Tide cause little, suppression ratio reaches 45.6%, compare with vegetable oil and former DIEDA WANHUAYOU matched group, difference has the significance meaning.
The pharmacodynamic study of Wanhua oil Babu plaster for traumatic injury
1, the cataplasma Dichlorodiphenyl Acetate causes the analgesic activity of pain mice
Select healthy NIH mice for use, male and female half and half.0.5h after the last administration, lumbar injection 0.7% acetum 0.1ml/10g, use manual time-keeping simultaneously, write down the pain that each Mus the time (being incubation period) of the 1st writhing response occurs and observe mice in the 15min and turn round the body number of times, stretch with typical hind leg, the abdominal part distortion, abdominal muscle is punctured into standard, large, medium and small dosage group of Wanhua oil Babu plaster for traumatic injury and blank matrix group, former dosage form group are relatively carried out one factor analysis of variance.Significance level P＜0.05.The results are shown in Table.
The Wanhua oil Babu plaster for traumatic injury Dichlorodiphenyl Acetate cause mouse writhing experiment (x ± SD, n=12)
| Group | The time (min) of body appears turning round for the first time | What occur in the 15min turns round the body number of times | Suppression ratio (%) |
| Dosage group cataplasma high dose group in the blank matrix group oil preparation group cataplasma low dose group cataplasma | 2.92±1.31 7.21±2.48** 6.43±3.09* 7.11±2.85** 6.80±3.54** | 26.6±7.7 15.2±5.4** 20.3±4.2* 16.9±7.5** 16.7±5.5** | 42.8 23.7 36.5 37.2 |
Annotate: compare * P＜0.05, * * P＜0.01 with blank matrix group.
The result shows: the large, medium and small dosage group of Wanhua oil Babu plaster for traumatic injury all can prolong mice analgesia incubation period, and can reduce mice turn round the body number of times, illustrate that Wanhua oil Babu plaster for traumatic injury has significant analgesia role.
2, cataplasma causes the analgesic activity of pain mice to hot plate method
Get the qualified female Kunming mouse in the threshold of pain, random packet, grouping and dosage be with under 1.3, in last administration 0.5h, 1h, 1.5h puts into 55 ± 0.5 ℃ of hot plate water-baths with mice. measure pain threshold respectively.Large, medium and small dosage group of Wanhua oil Babu plaster for traumatic injury and blank matrix group, former dosage form group are relatively carried out one factor analysis of variance.The results are shown in Table.
Wanhua oil Babu plaster for traumatic injury to thermostimulation cause mice pain experiment influence (x ± s, n=12)
| Group | Pain threshold (s) | Different time mice pain threshold (s) after the administration | ||
| 0.5h | 1h | 1.5h | ||
| Blank matrix group oil preparation group cataplasma low dose group | 22.6±4.7 22.3±5.4 23.1±3.8 | 23.6±6.1 30.7±9.5* 25.4±10.7 | 20.7±5.9 35.8±10.4* 27.6±11.4 | 19.8±7.2 39.4±8.3** 32.4±8.6* |
| Dosage group cataplasma high dose group in the cataplasma | 22.8±4.8 23.4±3.9 | 27.6±11.2 36.8±9.6* | 37.5±7.2* 38.5±10.8* | 42.6±8.5** 44.2±9.6** |
Annotate: compare * P＜0.05, * * P＜0.01 with blank matrix group.
The result shows: the big or middle dosage group of Wanhua oil Babu plaster for traumatic injury can significantly improve the mice pain threshold, has significant analgesia role.
3. cataplasma is to the inhibitory action of mice ear
Choose healthy Kunming mouse, 0.5h after the last administration evenly is applied to two sides, every mouse right ear exterior feature front and back with dimethylbenzene 0.03ml and causes inflammation, and left ear is coated with the equivalent normal saline in contrast.Cause scorching back 2h, take off neck and put to death, use the same position homalographic cutting-out of the card punch of diameter 8mm with left and right sides auricle, accurately weigh respectively, the difference of two auricle weight is as the swelling degree.Cataplasma group and blank matrix group, former dosage form group are relatively carried out one factor analysis of variance.The results are shown in Table.
The Wanhua oil Babu plaster for traumatic injury xylol cause mice ear antiinflammatory action (x ± s, n=12)
| Group | Ear swelling (mg) | Suppression ratio (%) |
| Dosage group cataplasma high dose group in the blank matrix group oil preparation group cataplasma low dose group cataplasma | 14.6±4.1 10.3±3.5** 12.3±2.7* 10.6±2.9** 10.2±4.0** | 29.5 20.1 27.4 30.1 |
Annotate: compare * P＜0.01, * * P＜0.05 with blank matrix group
The result shows, Wanhua oil Babu plaster for traumatic injury can obviously suppress the mice auricle swelling that caused by dimethylbenzene.
Pharmacodynamics test proof cataplasma is respectively organized the Dichlorodiphenyl Acetate induced mice and is turned round the body number of times and obviously reduce wherein middle and high dosage group effect the most obvious (P＜0.01) than the blank group; Simultaneously can also significantly improve hot plate method mice pain threshold, the prompting Wanhua oil Babu plaster for traumatic injury has significant analgesia role.Each group of Wanhua oil Babu plaster for traumatic injury can have the obvious suppression effect by xylol induced mice auricle edema, and similar to the DIEDA WANHUAYOU effect, the prompting Wanhua oil Babu plaster for traumatic injury has the obvious suppression effect to acute inflammation.
Further set forth technical scheme of the present invention below by embodiment
The specific embodiment
Embodiment 1:
1. the preparation of medicinal part
The material of getting it filled:
Flos Chrysanthemi Indici 403.2g Radix Linderae 105g Flos Cleistocalycis Operculati 263.2g
Radix Cynanchi Paniculati 105g Bulbus Allii 210g Herba Portulacae 105g
Herba Alii fistulosi 210g leaf of Flos Lonicerae 105g Caulis Kadsurae Coccineae 210g
Radix Clematidis 105g Cortex Gossampini 105g TUXIXIN 105g
Flos puerariae lobatae 193.2g Herba Polycarpaeae Corymbosae 105g Caulis Tinosporae 140g
Fructus Cnidii 105g Radix berchemiae lineatae 140g Radix achyranthis asperae (Herba Achyranthis Asperae) 105g
Lignum Sappan 140g Radix Et Rhizoma Rhei 105g Inula cappa (Ham.) DC. 140g
Radix Ardisiae Crenatae 105g Herba Jussiaeae Repentis 140g Herba Pileae Scriptae 105g
Herba Hyperici Japonici 140g Herba Duchesneae Indicae 105g Radix Zanthoxyli 140g
Herba Lycopi 105g Flos Carthami 140g Flos Eriocauli 105g
Rhizoma Stahlianthi Involucrati 140g Flos Bombacis Malabarici 193.2g Herba artemisiae lactiflorae 105g
Radix Saposhnikoviae 105g Cacumen Platycladi 105g Semen Strychni 105g
Balsamiferou Blumea Herb 105g Flos Mume 105g Herba Ecliptae 70g
JIUCENGTA 70g Ramulus Salicis Babylonicae 70g Fructus Gardeniae 70g
Semen Ricini 70g rhizoma sparganic (system) 70g Herba polygoni hydropiperis 70g
Rhizoma Curcumae (system) 70g Semen Hydnocarpi (core) 70g Folium Nelumbinis 70g
Herba Selaginellae 70g Fructus Viticis 70g Fructus Gleditsia 44g
Radix Angelicae Dahuricae 44g Rhizoma Drynariae 35g Semen Persicae 35g
Cortex Moutan 35g Rhizoma Chuanxiong (system) 35g Exocarpium Citri Grandis 35g
Pericarpium Citri Reticulatae Viride 35g Pericarpium Citri Reticulatae 35g Pseudobulbus Bletillae (Rhizoma Bletillae) 35g
Rhizoma Coptidis 35g Radix Paeoniae Rubra 35g Pollen Typhae 35g
Fructus Xanthii 35g Arisaema Cum Bile 26.32g Lacca 26.32g
Radix orixae japonicae 17.5g Rhizoma Cyperi (system) 17.5g Semen Myristicae 17.5g
Fructus Amomi 17.5g Radix Arnebiae (Radix Lithospermi) 17.5g Rhizoma Et Radix Notopterygii 17.5g
Semen Alpiniae Katsumadai 17.5g Radix Angelicae Pubescentis 17.5g Rhizoma Zingiberis 17.5g
Fructus Piperis Longi 17.5g Resina Liquidambaris 140g
Put in the carbon dioxide supercritical fluid extraction still, in extracting pressure 30Mpa, separating pressure 5MPa, 50 ℃ of extraction temperature, 40 ℃ of separation temperatures, extraction 2h extraction separation obtains fat-soluble extract 700g under the condition of flow 30.0Kg/h.
According to recipe quantity the mixed volatilization oil of Oleum menthae beyond the Chinese crude drugs of extract and 77 flavors, Oleum Terebinthinae, Oleum Camphora, Oleum Eucalypti, Oleum Ocimi Gratissimi, Oleum Anisi Stellati, Oleum Cinnamomi and methyl salicylate, Borneolum Syntheticum are formed 1964g
2. write out a prescription: crosslinked polypropylene acid resin (Carbopol
Ultrez10) 3g
Sodium polyacrylate 4g
Glycerol 23g
Citric acid 0.15g
Aluminum chloride 0.1g
Medicinal part 2.0g
3. the preparation of substrate
1) with Carbopol
The Ultrez10 resin is sprinkling upon in the deionized water, treats after the polymer moistening dispersion liquid stirring at low speed 30 minutes, is made into about 5% aqueous solution, as the A phase.
2) citric acid is made into 50% solution, aluminum chloride is made into 2.5% solution, the two mixing is obtained a clear solution, as the B phase.
3) under stirring at low speed, sodium polyacrylate 4g disperseed with glycerite in, and be stirred to and be uniformly dispersed, as the C phase.
4) under stirring at low speed, B is added to C mutually in.
5) stirring is added to A in the mixture of B, C phase down, and it is even to continue to be stirred to mastic, gets final product.
4. the preparation of cataplasma
Under stirring medicinal part is added in the substrate, and continue to be stirred to dispersion of medicine, coat the about 1000cm of back lining materials
2, drying, the covering protection material gets final product.
Paste containing amount measurement result: 6.8g/100cm
2(according to " paste containing amount algoscopy second method is measured under Chinese Pharmacopoeia (version in 2005) the appendix II emplastrum item).Determination of water result: 53% (g/g) (according to " second method is measured under Chinese pharmacopoeia (version in 2005) the appendix IX H aquametry item)
Embodiment 2:
1. the preparation of medicinal part is with embodiment 1
2. write out a prescription: crosslinked polypropylene acid resin (Carbopol
Ultrez10) 3g
Sodium polyacrylate 4g
Glycerol 23g
Medicinal part 2.0g
3. the preparation of substrate
1) with Carbopol
The Ultrez10 resin is sprinkling upon in the deionized water, treats after the polymer moistening dispersion liquid stirring at low speed 30 minutes, is made into about 5% aqueous solution, as the A phase.
2) under stirring at low speed, sodium polyacrylate 4g disperseed with glycerite in, and be stirred to and be uniformly dispersed, as the B phase.
3) stirring is added to A among the B down, and it is even to continue to be stirred to mastic, gets final product.
4. the preparation of cataplasma: with embodiment 1
Paste containing amount measurement result: 6g/100cm
2(assay method is with example 1)
Determination of water result: 48% (g/g) (assay method is with example 1)
Embodiment 3:
1. the preparation of medicinal part is with embodiment 1
2. write out a prescription: crosslinked polypropylene acid resin (Carbopol
Ultrez21) 1g
Sodium polyacrylate 10g
Glycerol 27g
Citric acid 0.15g
Aluminum chloride 0.1g
Medicinal part 3.0g
3. the preparation of substrate
1) with Carbopol
The Ultrez21 resin is sprinkling upon in the deionized water, treats after the polymer moistening dispersion liquid stirring at low speed 30 minutes, is made into 5% aqueous solution, as the A phase.
2) citric acid is made into 50% solution, aluminum chloride is made into 2.5% solution, the two mixing is obtained a clear solution, as the B phase.
3) under stirring at low speed, sodium polyacrylate 10g disperseed with the 27g glycerite in, can add appropriate amount of deionized water, and be stirred to and be uniformly dispersed, as the C phase.
4) under stirring at low speed, B is added to C mutually in.
5) stirring is added to A in the mixture of B, C phase down, and it is even to continue to be stirred to mastic, gets final product.
4. the preparation of cataplasma: with embodiment 1
Paste containing amount measurement result: 6.5g/100cm
2(assay method is with example 1)
Determination of water result: 51% (g/g) (assay method is with example 1)
Embodiment 4:
1. the preparation of medicinal part is with embodiment 1
2. write out a prescription: crosslinked polypropylene acid resin (Carbopol
Ultrez981) 1g
Sodium polyacrylate 7g
Glycerol 18g
Citric acid 0.15g
Aluminum chloride 0.1g
Medicinal part 5.0g
3. the preparation of substrate
1) with Carbopol
The Ultrez981 resin is sprinkling upon in the deionized water, treats after the polymer moistening dispersion liquid stirring at low speed 30 minutes, is made into 5% aqueous solution, as the A phase.
2) citric acid is made into 50% solution, aluminum chloride is made into 2.5% solution, the two mixing is obtained a clear solution, as the B phase.
3) under stirring at low speed, sodium polyacrylate 7g disperseed with 15 glycerites in, can add appropriate amount of deionized water, and be stirred to and be uniformly dispersed, as the C phase.
4) under stirring at low speed, B is added to C mutually in.
5) stirring is added to A in the mixture of B, C phase down, and it is even to continue to be stirred to mastic, gets final product.
4. the preparation of cataplasma: with embodiment 1 operation
Paste containing amount measurement result: 5.9g/100cm
2(assay method is with example 1)
Determination of water result: 51% (g/g) (assay method is with example 1)
Embodiment 5:
1. the preparation of medicinal part is with embodiment 1
2. write out a prescription: crosslinked polypropylene acid resin (Carbopol
Ultrez980) 3g
Sodium polyacrylate 10g
Glycerol 22g
Citric acid 0.15g
Aluminum chloride 0.1g
Medicinal part 4.0g
3. the preparation of substrate
1) with Carbopol
The Ultrez980 resin is sprinkling upon in the deionized water, treats after the polymer moistening dispersion liquid stirring at low speed 30 minutes, is made into 5% aqueous solution, as the A phase.
2) citric acid is made into 50% solution, aluminum chloride is made into 2.5% solution, the two mixing is obtained a clear solution, as the B phase.
3) under stirring at low speed, sodium polyacrylate 10g disperseed with 22 glycerites in, can add appropriate amount of deionized water, and be stirred to and be uniformly dispersed, as the C phase.
4) under stirring at low speed, B is added to C mutually in.
5) stirring is added to A in the mixture of B, C phase down, and it is even to continue to be stirred to mastic, gets final product.
4. the preparation of cataplasma: with embodiment 1
Paste containing amount measurement result: 7.5g/100cm
2(assay method is with example 1)
Determination of water result: 48% (g/g) (assay method is with example 1)
Embodiment 6:
1. the preparation of medicinal part is with embodiment 1
2. write out a prescription: crosslinked polypropylene acid resin (Carbopol
Ultrez10) 5g
Sodium polyacrylate 7g
Glycerol 20g
Citric acid 0.15g
Aluminum chloride 0.1g
Medicinal part 3.50g
3. the preparation of substrate
1) with Carbopol
The Ultrez10 resin is sprinkling upon in the deionized water, treats after the polymer moistening dispersion liquid stirring at low speed 30 minutes, is made into 5% aqueous solution, as the A phase.
2) citric acid is made into 50% solution, aluminum chloride is made into 2.5% solution, the two mixing is obtained a clear solution, as the B phase.
3) under stirring at low speed, sodium polyacrylate 7g disperseed with the 20g glycerite in, can add appropriate amount of deionized water, and be stirred to and be uniformly dispersed, as the C phase.
4) under stirring at low speed, B is added to C mutually in.
5) stirring is added to A in the mixture of B, C phase down, and it is even to continue to be stirred to mastic, gets final product.
4. the preparation of cataplasma:, coat the about 500cm of back lining materials with embodiment 1 operation
2, drying, the covering protection material gets final product.
Paste containing amount measurement result: 15g/100cm
2(assay method is with example 1)
Determination of water result: 52% (g/g) (assay method is with example 1)
Embodiment 7:
1. the preparation of medicinal part is with embodiment 1
2. write out a prescription: crosslinked polypropylene acid resin (Carbopol
Ultrez10) 4g
Sodium polyacrylate 8g
Glycerol 25g
Medicinal part 4.0g
3. the preparation of substrate
With embodiment 2
4. the preparation of cataplasma: with embodiment 1
Paste containing amount measurement result: 9.1g/100cm
2(assay method is with example 1)
Determination of water result: 55% (g/g) (assay method is with example 1)
Embodiment 8:
1. the preparation of medicinal part is with embodiment 1
2. write out a prescription: crosslinked polypropylene acid resin (Carbopol
Ultrez21) 2g
Sodium polyacrylate 8g
Glycerol 22g
Citric acid 0.15g
Aluminum chloride 0.1g
Medicinal part 2.50g
3. the preparation of substrate
1) with Carbopol
The Ultrez21 resin is sprinkling upon in the deionized water, treats after the polymer moistening dispersion liquid stirring at low speed 30 minutes, is made into 5% aqueous solution, as the A phase.
2) citric acid is made into 50% solution, aluminum chloride is made into 2.5% solution, the two mixing is obtained a clear solution, as the B phase.
3) under stirring at low speed, sodium polyacrylate 8g disperseed with the 22g glycerite in, can add appropriate amount of deionized water, and be stirred to and be uniformly dispersed, as the C phase.
4) under stirring at low speed, B is added to C mutually in.
5) stirring is added to A in the mixture of B, C phase down, and it is even to continue to be stirred to mastic, gets final product.
4. the preparation of cataplasma: with embodiment 1
Paste containing amount measurement result: 5.8g/100cm
2(assay method is with example 1)
Determination of water result: 40% (g/g) (assay method is with example 1)
Embodiment 9:
1. the preparation of medicinal part is with embodiment 1
2. write out a prescription: crosslinked polypropylene acid resin (Carbopol
Ultrez981) 2g
Sodium polyacrylate 7g
Glycerol 17g
Citric acid 0.15g
Aluminum chloride 0.1g
Medicinal part 5.50g
3. the preparation of substrate
1) with Carbopol
The Ultrez981 resin is sprinkling upon in the deionized water, treats after the polymer moistening dispersion liquid stirring at low speed 30 minutes, is made into 5% aqueous solution, as the A phase.
2) citric acid is made into 50% solution, aluminum chloride is made into 2.5% solution, the two mixing is obtained a clear solution, as the B phase.
3) under stirring at low speed, sodium polyacrylate 7g disperseed with the 17g glycerite in, can add appropriate amount of deionized water, and be stirred to and be uniformly dispersed, as the C phase.
4) under stirring at low speed, B is added to C mutually in.
5) stirring is added to A in the mixture of B, C phase down, and it is even to continue to be stirred to mastic, gets final product.
4. the preparation of cataplasma: with embodiment 1
Paste containing amount measurement result: 7.9g/100cm
2(assay method is with example 1)
Determination of water result: 60% (g/g) (assay method is with example 1)
Embodiment 10:
1. the preparation of medicinal part is with embodiment 1
2. write out a prescription: crosslinked polypropylene acid resin (Carbopol
Ultrez10) 5g
Sodium polyacrylate 4g
Glycerol 28g
Medicinal part 1.50g
3. the preparation of substrate
With embodiment 2
4. the preparation of cataplasma:, coat the about 500cm of back lining materials with embodiment 1
2
Paste containing amount measurement result: 14g/100cm
2(assay method is with example 1)
Determination of water result: 46% (g/g) (assay method is with example 1)
Determination of water result: 48% (v/g) (assay method is with example 1).
Claims (4)
1, a kind of Wanhua oil Babu plaster for traumatic injury is that the prescription raw material cataplasma technology routinely by DIEDA WANHUAYOU is prepared from by back lining materials, medicinal part and substrate composed plaster and coverlay, it is characterized in that: every 100cm
2Cataplasma be coated with adhesive plaster 5～15g, contain medicinal position 0.5～15.0g in the 100g plaster, moisture 40～60g, surplus is hydrophilic matrix.
Said hydrophilic matrix is made up of following weight portion raw material:
1.0～5.0 parts of crosslinked polypropylene acid resins
2.0～10.0 parts of sodium polyacrylate
18.0～30.0 parts of glycerol
Said medicinal part is to be made by following 86 flavor raw materials:
[prescription]
Flos Chrysanthemi Indici 288g Radix Linderae 75g Flos Cleistocalycis Operculati 188g
Radix Cynanchi Paniculati 75g Bulbus Allii 150g Herba Portulacae 75g
Herba Alii fistulosi 150g leaf of Flos Lonicerae 75g Caulis Kadsurae Coccineae 150g
Radix Clematidis 75g Cortex Gossampini 75g TUXIXIN 75g
Flos puerariae lobatae 138g Herba Polycarpaeae Corymbosae 75g Caulis Tinosporae 100g
Fructus Cnidii 75g Radix berchemiae lineatae 100g Radix achyranthis asperae (Herba Achyranthis Asperae) 75g
Lignum Sappan 100g Radix Et Rhizoma Rhei 75g Inula cappa (Ham.) DC. 100g
Radix Ardisiae Crenatae 75g Herba Jussiaeae Repentis 100g Herba Pileae Scriptae 75g
Herba Hyperici Japonici 100g Herba Duchesneae Indicae 75g Radix Zanthoxyli 100g
Herba Lycopi 75g Flos Carthami 100g Flos Eriocauli 75g
Rhizoma Stahlianthi Involucrati 100g Flos Bombacis Malabarici 138g Herba artemisiae lactiflorae 75g
Radix Saposhnikoviae 75g Cacumen Platycladi 75g Semen Strychni 75g
Balsamiferou Blumea Herb 75g Flos Mume 75g Herba Ecliptae 50g
JIUCENGTA 50g Ramulus Salicis Babylonicae 50g Fructus Gardeniae 50g
Semen Ricini 50g rhizoma sparganic (system) 50g Herba polygoni hydropiperis 50g
Rhizoma Curcumae (system) 50g Semen Hydnocarpi (core) 50g Folium Nelumbinis 50g
Herba Selaginellae 50g Fructus Viticis 50g Fructus Gleditsia 44g
Radix Angelicae Dahuricae 44g Rhizoma Drynariae 25g Semen Persicae 25g
Cortex Moutan 25g Rhizoma Chuanxiong (system) 25g Exocarpium Citri Grandis 25g
Pericarpium Citri Reticulatae Viride 25g Pericarpium Citri Reticulatae 25g Pseudobulbus Bletillae (Rhizoma Bletillae) 25g
Rhizoma Coptidis 25g Radix Paeoniae Rubra 25g Pollen Typhae 25g
Fructus Xanthii 25g Arisaema Cum Bile 18.8g Lacca 18.8g
Radix orixae japonicae 12.5g Rhizoma Cyperi (system) 12.5g Semen Myristicae 12.5g
Fructus Amomi 12.5g Radix Arnebiae (Radix Lithospermi) 12.5g Rhizoma Et Radix Notopterygii 12.5g
Semen Alpiniae Katsumadai 12.5g Radix Angelicae Pubescentis 12.5g Rhizoma Zingiberis 12.5g
Fructus Piperis Longi 12.5g Resina Liquidambaris 100g Borneolum Syntheticum 120g
Oleum menthae 200g Oleum Terebinthinae 180g methyl salicylate 120g
Oleum Camphora 100g Oleum Eucalypti 75g Oleum Ocimi Gratissimi 52.8g
Oleum Anisi Stellati 50g Oleum Cinnamomi 5g
Get recipe quantity Flos Chrysanthemi Indici to 77 flavor Chinese crude drugs of Resina Liquidambaris and extract liposoluble extract and Oleum menthae, Oleum Terebinthinae, Oleum Camphora, Oleum Eucalypti, Oleum Ocimi Gratissimi, Oleum Anisi Stellati, Oleum Cinnamomi and methyl salicylate beyond the 77 flavor Chinese crude drugs and the medicinal part of Borneolum Syntheticum posterior portion composition obtain with the carbon dioxide supercritical fluid extraction method.
2. Wanhua oil Babu plaster for traumatic injury as claimed in claim 1 is characterized in that: also have citric acid and aluminum chloride in the said hydrophilic matrix, be made up of following weight portion raw material:
1.0～5.0 parts of crosslinked polypropylene acid resins
2.0～10.0 parts of sodium polyacrylate
18.0～30.0 parts of glycerol
0.15 part of citric acid
0.1 part of aluminum chloride.
3, a kind of preparation method of Wanhua oil Babu plaster for traumatic injury as claimed in claim 1 is characterized in that carrying out as follows:
One, be employing carbon dioxide supercritical fluid extraction method with Flos Chrysanthemi Indici to 77 flavor Chinese crude drugs of Resina Liquidambaris with the method for extracting effective site by recipe quantity, by recipe quantity Flos Chrysanthemi Indici to 77 flavor Chinese crude drugs of Resina Liquidambaris are thrown in the carbon dioxide supercritical fluid extraction still, at extracting pressure 15-40Mpa, separating pressure 3-8MPa, extraction temperature 30-60 ℃, separation temperature 30-40 ℃, extraction 1-5h separates and obtains fat-soluble extract under the condition of flow 26.0-32.0Kg/h;
Two, press recipe quantity with Oleum menthae, Oleum Terebinthinae, Oleum Camphora, Oleum Eucalypti, Oleum Ocimi Gratissimi, Oleum Anisi Stellati, seven kinds of oily mix homogeneously of Oleum Cinnamomi, methyl salicylate and the Borneolum Syntheticum of getting recipe quantity are dissolved in the mixed even mixture that gets of mixed volatilization oil, and be standby;
Three, get the extract that the first step makes, adding second mixture that goes on foot mixed is medicinal part evenly;
Four, the preparation of substrate
1. the crosslinked polypropylene acid resin is sprinkling upon in the deionized water, treated after the polymer moistening dispersion liquid stirring at low speed 30 minutes, as the A phase,
2. under stirring at low speed, sodium polyacrylate is scattered in the glycerol, and is stirred to and is uniformly dispersed, as the B phase,
3. stir down A is added to B mutually in, it is even to continue to be stirred to mastic, gets final product;
Five, the preparation of cataplasma
Under stirring medicinal part is added in the substrate, and continue to be stirred to dispersion of medicine, coat on the back lining materials, drying, covered with protective film gets final product.
4, the preparation method of Wanhua oil Babu plaster for traumatic injury according to claim 3 is characterized in that
Four, the preparation of substrate:
1. the crosslinked polypropylene acid resin is sprinkling upon in the deionized water, treated after the polymer moistening dispersion liquid stirring at low speed 30 minutes, as the A phase,
2. citric acid and aluminum chloride are dissolved respectively, and mix and to obtain a clear solution, as the B phase,
3. stir down sodium polyacrylate is disperseed with glycerol in, and be stirred to and be uniformly dispersed, as the C phase,
4. stir down B is added to C mutually in,
5. under stirring A is added in the mixture of B, C phase, it is even to continue to be stirred to mastic, gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100364677A CN100387295C (en) | 2006-07-13 | 2006-07-13 | Wanhua oil Babu plaster for traumatic injury and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100364677A CN100387295C (en) | 2006-07-13 | 2006-07-13 | Wanhua oil Babu plaster for traumatic injury and preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1899592A true CN1899592A (en) | 2007-01-24 |
| CN100387295C CN100387295C (en) | 2008-05-14 |
Family
ID=37655704
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100364677A Active CN100387295C (en) | 2006-07-13 | 2006-07-13 | Wanhua oil Babu plaster for traumatic injury and preparing method |
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| Country | Link |
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| CN (1) | CN100387295C (en) |
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| CN103230618A (en) * | 2013-05-10 | 2013-08-07 | 李宏江 | Wet dressing towelette for emergency treatment of trauma |
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| CN108771753A (en) * | 2018-07-04 | 2018-11-09 | 广州白云山敬修堂药业股份有限公司 | A kind of dieda wanhua oil hard ointment and preparation method thereof |
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| CN108771753B (en) * | 2018-07-04 | 2021-08-13 | 广州白云山敬修堂药业股份有限公司 | Traumatic injury kaleidoscope oil hard ointment and preparation method thereof |
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Owner name: GUANGZHOU BAIYUNSHAN JINGXIUTANG PHARMACEUTICAL CO Free format text: FORMER NAME: JINGXIUTANG (PHARMACEUTICAL) CO., LTD., GUANGZHOU;JINGXIUTANG (PHARMACEUTICAL) CO., LTD., GUANGZHOU |
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Address after: 510130 No. 179 Renmin South Road, Guangzhou, Guangdong, Liwan District Patentee after: Guangzhou Baiyunshan Jingxiutang Pharmaceutical Company Limited Address before: 510130 No. 179 Renmin South Road, Guangzhou, Guangdong, Liwan District Patentee before: Jingxiutang (Pharmacy) Co., Ltd., Guangzhou |