CN1186010C - Vegetable oil fatty milk oral or injection preparation - Google Patents
Vegetable oil fatty milk oral or injection preparation Download PDFInfo
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- CN1186010C CN1186010C CNB021394350A CN02139435A CN1186010C CN 1186010 C CN1186010 C CN 1186010C CN B021394350 A CNB021394350 A CN B021394350A CN 02139435 A CN02139435 A CN 02139435A CN 1186010 C CN1186010 C CN 1186010C
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Abstract
The present invention discloses an oral preparation or an injection preparation of vegetable oil fatty milk, which comprises the main components of medicinal vegetable oil, lecithin used as an emulsifying agent, refined soybean oil or other refined oil used as an oil-soluble diluting agent and glycerol used as an isoosmotic adjusting agent. The injection preparation of vegetable oil fatty milk prepared by all or partial of the medicinal vegetable oil, the lecithin, the refined soybean oil and the glycerol is good in water solubility of the vegetable oil. The use of traditional auxiliary solvents with side effect is avoided, stimulation of medicines and the auxiliary solvents to blood vessels can be redued, and medicine efficiency can be improved.
Description
One, technical field
The invention belongs to field of medicaments, relate to fat emulsion formulation, particularly oral the or ejection preparation of vegetable oil fat milk.
Two, background technology
Fragrant plant and quintessence oil are just being used in by traditional medicines such as Er Beida uncommon cloth carat Euripides medical science and Ah a long time ago in a large number.Legendary spice of Greece's epoch " wheat strategic point dish father-in-law perfume (or spice) " allegedly can be controlled " any inflammation ", and Hippocrates use various aromatic substances as medicine, and relying on aromatic substance stifling is a kind of means that they treat disease.17,18th century quintessence oil distillation technique greatly progressive, be the epoch that quintessence oil is used for medicine, cosmetic in a large number.Begin in the middle of the 19th century, quintessence oil is the same with medicinal plants, be the epoch of not being used as medicine by people, but scientific progress has proved the medical effect of quintessence oil conversely again.People's such as Paris Institute Pasteur Xiang Bulu research report: the antibacterial of yellow fever, use aromatic oil to be killed easily.It is reported the most effectively: Oleum Cinnamomi, Oleum thymi vulgaris, Common Wormwood oil, Herba Verbenae oil, Essential lavender oil, Herba Pogostemonis oil, Radix Angelicae Sinensis oil, Du Shan oil, sandal oil, Cupressus funebris Endl. wet goods.
The fragrance index can be classified to the effect of quintessence oil antimicrobial effectiveness, it is that quintessence oil medium measure of effectiveness number of anti-different microorganisms in large quantities of clinical diseases row is average and get, and is arranged in order from big to small by the fragrance exponential quantity to be Herba Origani oil, thyme oil, Oleum Cinnamomi, Oleum Caryophylli, cajeput oil, Oleum Rosae Rugosae, pine oil, fennel oil, Essential lavender oil, Myrtus communis oil.These all are the natural essential oils that is usually used in treating disease, and wherein the fragrance index of Herba Origani oil is 0.873, and Myrtus communis oil is 0.250, show that comprehensive (pressing down) bacterium ability of killing of Herba Origani oil is the strongest also the most effective.
From the age of recent antiquity for over ten years to the cure the disease achievement in research of bacterium of quintessence oil, the quintessence oil that various plant extract are come out (comprising resin, extractum etc.) except the disease-resistant bacterium effect of broad-spectrum, analgesic effect, Detoxication, more creation with, enhance metabolism and the endocrine effect, promote the capable effect of blood, adjust blood pressure effect, whole intestinal effect and various direct therapeutical effect and excite the healing power effect of human body itself are good for the stomach.
The quality control of medicinal plants quintessence oil injection is a key issue, because injection is an approach of taking drug administration by injection, directly enters in the body without digestive tube absorbs, so quality control must be strict.But medicinal plants quintessence oil injection great majority are formulated through extracting after refining with the medical material plants essential oil, objectively there is impurity, the active substance content difference is bigger, bring problems such as pyrogen easily into, done many further investigation work in these areas in recent years both at home and abroad, tackled key problems one by one to closing concrete kind.At the characteristics of Chinese medicine, stipulated a series of conventional quality inspection project and standard, some Chinese medicine quality are reached a standard.A kind of dosage form of Chinese medicine as Chinese medicine being described, finalizing the design almost, and demonstrate the advantage of its uniqueness, is a kind of coming form of Chinese drug.Especially at aspects such as developing Chinese medicine, the treatments of solution tcm emergency, will be must obligato a kind of main dosage form.Not only " little pin " kind will increase, and infusion solution also will progressively reach a standard, and then goes into operation and satisfy tcm clinical practice medication requirement.
Oil does not dissolve in water owing to medicine, so the medicine fat injection of present market sale is by the conventional formulation method, needs to add the composite solution (as adding cosolvent Tween 80, ethanol, propylene glycol, glycerol etc. in the aqueous solution in addition) that cosolvent is made into aqueous solution or water.Nonetheless, still can not well solve the clarity and the stability of preparation.Long-term placement can be separated out oil droplet.Organic solvent has certain toxicity, and blood vessel is had stimulation.In recent years about the uncontrollability of the pharmacological action of Tween 80 and quality thereof to the influence of Chinese medicine injection stability, Tween 80 to the interference of drug detection, temperature report to the influence of Tween 80 solution pH value and clarity, caused the concern of drug surveilance mechanism and medicament research and development unit.Though Tween 80 has good solubilizing effect, certain pharmacological action and toxicity are also arranged, as heart is had inhibitory action; Can cause that blood pressure slightly descends; Still influential to erythrocytic stability; Can bring out human lymphocyte SCE increase frequency, and damage dna duplicates template, mutagenic probability is arranged.Also have the people once to give volunteer's intramuscular injection with 2% Tween 80 injection, the part that the clinical discovery Tween 80 causes goes up painful sense and can continue more than 24 hours.
Three, summary of the invention
The objective of the invention is to avoid using cosolvent Tween 80, ethanol and the propylene glycol of side effect, utilize emulsifying technology that plants essential oil is dispersed in the microemulsion, make the fat milk medicine hydraulic fluid port clothes or the ejection preparation that have no side effect.The fat milk ejection preparation is very sophisticated parenteral nutrition and energy supplement medicinal liquid injection.Its main component comprises refined soybean oil, lecithin and glycerol.Their effect is respectively oil-soluble diluent, emulsifying agent and isoosmotic adjusting agent.Refined soybean oil, lecithin and glycerol all are natural products, and is not only nontoxic, have no side effect, or patient nutrition and energy supplement that use always, that easily absorb.
Realize that the technical scheme that the foregoing invention purpose is adopted is, oral or the ejection preparation agent of this vegetable oil fat milk, by water for injection and medicinal plant oil, as the lecithin of emulsifying agent, as refined soybean oil or other refined oil and formulated as the glycerol of isoosmotic adjusting agent of oil-soluble diluent, its consumption weight ratio is:
1) medicinal plant oil 0.1%-30%;
2) as the lecithin 5%-20% of emulsifying agent;
3) as refined soybean oil or other refined oil 0-30% of oil-soluble diluent;
4) as the glycerol 0.15%-0.25% of isoosmotic adjusting agent
Surplus is a water for injection, is the 0.5-3 isotonic concentration as the final osmotic pressure of the glycerol of isoosmotic adjusting agent wherein.
Said medicinal plant oil is the fat-soluble medicine that can be dissolved in the refined oil, and they are:
Oleum Curcumae, Oleum Bulbus Allii, Rhizoma Chuanxiong oil, Herba Artemisiae Annuae oil, Oleum Hippophae, wintergreen oil, Radix Oenotherae erythrosepalae oil, Radix Angelicae Sinensis oil, oil of Rhizoma Zingiberis Recens, Herba Schizonepetae oil, Fructus Forsythiae oil, eucalyptus oil, perilla oil, Oleum Citri Reticulatae, Oleum Viticis Negundo, Oleum Rosae Rugosae, Oleum Ricini, Oleum menthae, oil of Herba Artemisiae Scopariae, fennel oil, pine oil, Oleum Caryophylli, Oleum Anisi Stellati, Oleum thymi vulgaris, Oleum Cinnamomi, Oleum Folium Artemisiae Argyi, Fructus Perillae oil, turmeric oil, cajeput oil, Essential lavender oil, Radix Aucklandiae oil, patchouli oil, Herba Verbenae oil, Common Wormwood oil, Salvia Sclare L.oil, Rhizoma Atractylodis oil, Myrtus communis oil, Fructus Citri Limoniae oil, Fructus Aurantii Immaturus oil, Oleum Ocimi Gratissimi, Folium Perillae oil, art pomegranate oil, Oleum Cocois, Fructus Amomi oil, olive oil, citronella oil, Oleum Pelargonii Graveolentis, Herba Moslae oil, Oleum Menthae Rotundifoliae, Du Shan oil, Herba Pogostemonis oil, Storax oil, oil of Ribes nigrum L., Fructus Schisandrae oil, Rhizoma Acori Graminei oil, Fructus Cnidii oil, Fructus Phellodendri oil, Oleum lavandula angustifolia, oil of rosemary, oleum bergamottae, sandal oil, Fructus Dauci Sativae oil, Cacumen Cupressi oil, seed oil of Herba Apii graveolentis, Herba Origani oil, citronellal oil, Fructus Coriandri oil, orange blossom oil, Semen Myristicae oil, oil of Bulbus Allii Cepae, Oleum Santali albi, Flos Tagetis Erectae oil, thyme oil, in the Cananga odorata oil any.
Said lecithin as emulsifying agent can be: any of Ovum Gallus domesticus Flavus lecithin, soybean lecithin, hydrogenated yolk lecithin, hydrogenated soy phosphatidyl choline, synthetic lecithin.
Said refined soybean oil or other refined oil as the oil-soluble diluent can be: any in refined soybean oil, refined maize oil, refining Oleum Helianthi, refining Oleum Arachidis hypogaeae semen, refining Oleum sesami, the refining rapeseed oil.
The present invention utilizes the oil-soluble of medicine oil, and it is dissolved in the refined soybean oil, thereby makes the oral or ejection preparation of vegetable oil fat milk.So the present invention has also replenished nutrition for patient in the defective that has overcome the conventional medicine fat injection.
Four, description of drawings
Fig. 1 is a process chart of the present invention.
Five, the specific embodiment
For a more clear understanding of the present invention, the present invention is described in further detail for the embodiment that provides below in conjunction with accompanying drawing and inventor.
5. Fa Ming raw material, prescription, preparation technology and technological process, embodiment
5.1, the mainly effect of raw material in prescription of writing out a prescription:
| Adjuvant | Effect |
| Refining medicine oil | Medicine |
| Soybean oil (injection) | The oil-soluble diluent |
| Lecithin (injection) | Emulsifying agent |
| Glycerol | Isoosmotic adjusting agent |
5.2, preparation technology and technological process
Whole process of production is carried out under nitrogen protection.
Get the refining medicine oil of recipe quantity, soybean oil, adding lecithin stirs heated and stirred 10min to be made it to dissolve fully.Other gets water for injection, adds glycerol.Under the condition of nitrogen protection, the phospholipid oil solution is added in the glycerine water solution of using cutter high-speed stirred (3000r/min) slowly, under the condition of nitrogen protection, continue to stir 30min, promptly get colostrum solution.Through high pressure homogenizer homogenizing 7-8 time, pressure is 100MPa, to particle size range at 180-300nm, regulate pH 7.0-8.0, filter, packing feeds nitrogen, sealing, 115 ℃ of sterilization 30min, final products should be uniform milky solutions, do not have precipitation, layering and oil spill phenomenon.After lamp inspection is qualified, packing.In storage below 25 ℃.
Process chart of the present invention is referring to Fig. 1.
5.3, inventive embodiments
First: the amount ranges of medicine oil
The present invention verifies the amount ranges of listed medicine oil.The arbitrary consumption of consumption in 0.1-20% weight content scope at the listed medicine oil of claim of the present invention under technology of the present invention and the condition all guarantees to make the stable oral or ejection preparation of fat milk medicinal plant oil.Only be example with the Oleum Curcumae:
Embodiment 1: the oral or ejection preparation (0.1%, weight content) of curcuma zedoary oil fat
Prescription:
Oleum Curcumae 1.0g
Soybean oil (injection) 99.0g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Curcumae 1.0g, soybean oil 99g adds lecithin 12g, stir about 10min mixing, and other gets water for injection 800ml, adds glycerol 22g.Under the condition of nitrogen protection, the phospholipid oil solution is added in the glycerine water solution, regulate total amount to 1000ml.Through high pressure homogenizer homogenizing 7-8 time, homogenization pressure is 100MPa, to particle size range at 180nm-300nm, regulate pH 7.0-8.0, filter, packing feeds nitrogen, sealing.115 ℃ of sterilization 30min, after lamp inspection is qualified, packing.In storage below 25 ℃.
Embodiment 2: the oral or ejection preparation (1%, weight content) of curcuma zedoary oil fat
Prescription:
Oleum Curcumae 10g
Soybean oil (injection) 90g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Curcumae 10g, soybean oil 90g adds lecithin 12g, stir about 10min mixing, and other gets water for injection 800ml, adds glycerol 22g.Under the condition of nitrogen protection, the phospholipid oil solution is added in the glycerine water solution, regulate total amount to 1000ml.Through high pressure homogenizer homogenizing 7-8 time, homogenization pressure is 100MPa, to particle size range at 180nm-300nm, regulate pH 7.0-8.0, filter, packing feeds nitrogen, sealing.115 ℃ of sterilization 30min, after lamp inspection is qualified, packing.In storage below 25 ℃.
Embodiment 3: the oral or ejection preparation (5%, weight content) of curcuma zedoary oil fat
Prescription:
Oleum Curcumae 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Curcumae 50g, soybean oil 50g adds lecithin 12g, stir about 10min mixing, and other gets water for injection 800ml, adds glycerol 22g.Under the condition of nitrogen protection, the phospholipid oil solution is added in the glycerine water solution, regulate total amount to 1000ml.Through high pressure homogenizer homogenizing 7-8 time, homogenization pressure is 100MPa, to particle size range at 180nm-300nm, regulate pH 7.0-8.0, filter, packing feeds nitrogen, sealing.115 ℃ of sterilization 30min, after lamp inspection is qualified, packing.In storage below 25 ℃.
Embodiment 4: the oral or ejection preparation (10%, weight content) of curcuma zedoary oil fat
Prescription:
Oleum Curcumae 100g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Curcumae 100g, add lecithin 12g, stir about 10min mixing, other gets water for injection 800ml, adds glycerol 22g.Under the condition of nitrogen protection, the phospholipid oil solution is added in the glycerine water solution, regulate total amount to 1000ml.Through high pressure homogenizer homogenizing 7-8 time, homogenization pressure is 100MPa, to particle size range at 180nm-300nm, regulate pH 7.0-8.0, filter, packing feeds nitrogen, sealing.115 ℃ of sterilization 30min, after lamp inspection is qualified, packing.In storage below 25 ℃.
Embodiment 5: the oral or ejection preparation (20%, weight content) of curcuma zedoary oil fat
Prescription:
Oleum Curcumae 200g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Curcumae 200g, add lecithin 12g, stir about 10min mixing, other gets water for injection 800ml, adds glycerol 22g.Under the condition of nitrogen protection, the phospholipid oil solution is added in the glycerine water solution, regulate total amount to 1000ml.Through high pressure homogenizer homogenizing 7-8 time, homogenization pressure is 100MPa, to particle size range at 180nm-300nm, regulate pH 7.0-8.0, filter, packing feeds nitrogen, sealing.115 ℃ of sterilization 30min, after lamp inspection is qualified, packing.In storage below 25 ℃.
Second portion: the amount ranges of refined soybean oil
The present invention verifies the amount ranges of listed refining diluent oil.The arbitrary consumption of consumption in 0-20% weight content scope in listed refining diluent oil under technology of the present invention and the condition all guarantees to make the stable oral or ejection preparation of fat milk medicinal plant oil.Be example still with Oleum Curcumae and soybean oil:
Embodiment 6: the oral or ejection preparation (Oleum Curcumae weight content 10%, soybean oil weight content 0%) of curcuma zedoary oil fat
Prescription:
Oleum Curcumae 100g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Curcumae 100g, add lecithin 12g, stir about 10min mixing, other gets water for injection 800ml, adds glycerol 22g.Under the condition of nitrogen protection, the phospholipid oil solution is added in the glycerine water solution.Through high pressure homogenizer homogenizing 7-8 time, pressure is 100MPa, to particle size range at 180nm-300nm, regulate pH 7.0-8.0.Regulate total medicinal liquid to 1000ml, filter and be sub-packed in the 50ml-100ml infusion bottle feeding nitrogen, sealing.115 ℃ of sterilization 30min, after lamp inspection is qualified, packing.In storage below 25 ℃.
Embodiment 7: the oral or ejection preparation (Oleum Curcumae weight content 10%, soybean oil weight content 10%) of curcuma zedoary oil fat
Prescription:
Oleum Curcumae 100g
Soybean oil (injection) 100g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1 000ml
Get refining Oleum Curcumae 100g, soybean oil 100g adds lecithin 12g, stir about 10min mixing, and other gets water for injection 800ml, adds glycerol 22g.Under the condition of nitrogen protection, the phospholipid oil solution is added in the glycerine water solution.Through high pressure homogenizer homogenizing 7-8 time, pressure is 100MPa, to particle size range at 180nm-300nm, regulate pH 7.0-8.0.Regulate total medicinal liquid to 1000ml, filter and be sub-packed in the 50ml-100ml infusion bottle feeding nitrogen, sealing.115 ℃ of sterilization 30min, after lamp inspection is qualified, packing.In storage below 25 ℃.
Embodiment 8: the oral or ejection preparation (Oleum Curcumae weight content 10%, soybean oil weight content 20%) of curcuma zedoary oil fat
Prescription:
Oleum Curcumae 100g
Soybean oil (injection) 200g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Curcumae 100g, soybean oil 200g adds lecithin 12g, stir about 10min mixing, and other gets water for injection 800ml, adds glycerol 22g.Under the condition of nitrogen protection, the phospholipid oil solution is added in the glycerine water solution.Through high pressure homogenizer homogenizing 7-8 time, pressure is 100MPa, to particle size range at 180nm-300nm, regulate pH 7.0-8.0.Regulate total medicinal liquid to 1000ml, filter and be sub-packed in the 50ml-100ml infusion bottle feeding nitrogen, sealing.115 ℃ of sterilization 30min, after lamp inspection is qualified, packing.In storage below 25 ℃.
Third part: the example of formulations of various medicine oil
The present invention verifies listed various medicine oil.Can make the oral or ejection preparation (referring to embodiment first) of stable fat milk medicinal plant oil at arbitrary consumption of consumption in 0.1-20% weight content scope of the listed medicine oil of claim of the present invention under technology of the present invention and the condition.This only optionally example go out the example of formulations of part medicine oil 5% weight content:
Embodiment 9: Oleum Hippophae fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Hippophae 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Hippophae 50g, soybean oil 50g adds lecithin 12g, stir about 10min mixing, and other gets water for injection 800ml, adds glycerol 22g.Under the condition of nitrogen protection; The phospholipid oil solution is added in the glycerine water solution, regulate total amount to 1000ml.Through high pressure homogenizer homogenizing 7-8 time, homogenization pressure is 100MPa, to particle size range at 180nm-300nm, regulate pH 7.0-8.0, filter, packing feeds nitrogen, sealing.115 ℃ of sterilization 30min, after lamp inspection is qualified, packing.In storage below 25 ℃.
Embodiment 10: Rhizoma Chuanxiong oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Rhizoma Chuanxiong oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Rhizoma Chuanxiong oil 50g, soybean oil 50g adds lecithin 12g, stir about 10min mixing, and other gets water for injection 800ml, adds glycerol 22g.Under the condition of nitrogen protection, the phospholipid oil solution is added in the glycerine water solution, regulate total amount to 1000ml.Through high pressure homogenizer homogenizing 7-8 time, homogenization pressure is 100MPa, to particle size range at 180nm-300nm, regulate pH 7.0-8.0, filter, packing feeds nitrogen, sealing.115 ℃ of sterilization 30min, after lamp inspection is qualified, packing.In storage below 25 ℃.
Embodiment 11: Fructus Cnidii oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Cnidii oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Fructus Cnidii oil 50g, carry out according to the method for embodiment 3.
Embodiment 12: Oleum Bulbus Allii fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Bulbus Allii 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml.
Get refined garlic oil 50g, carry out according to the method for embodiment 3.
Embodiment 13: big Herba Artemisiae Annuae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Herba Artemisiae Annuae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Herba Artemisiae Annuae oil 50g, carry out according to embodiment 3 methods.
Embodiment 14: Radix Angelicae Sinensis oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Radix Angelicae Sinensis oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refined angelica oil 50g, carry out according to embodiment 3 methods.
Embodiment 15: oenothera biennise oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Radix Oenotherae erythrosepalae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refinement of evening primrose oil 50g, carry out according to embodiment 3 methods.
Embodiment 16: wintergreen oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Wintergreen oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining wintergreen oil 50g, carry out according to embodiment 3 methods.
Embodiment 17: oil of Rhizoma Zingiberis Recens fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oil of Rhizoma Zingiberis Recens 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refined raw oil of ginger 50g, carry out according to embodiment 3 methods.
Embodiment 18: Herba Schizonepetae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Herba Schizonepetae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Herba Schizonepetae oil 50g, carry out according to embodiment 3 methods.
Embodiment 19: Fructus Forsythiae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Forsythiae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Fructus Forsythiae oil 50g, carry out according to embodiment 3 methods.
Embodiment 20: eucalyptus oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Eucalyptus oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining eucalyptus oil 50g, carry out according to embodiment 3 methods.
Embodiment 21: perilla herb oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Perilla oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining perilla oil 50g, carry out according to embodiment 3 methods.
Embodiment 22: Oleum Citri Reticulatae fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Citri Reticulatae 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Citri Reticulatae 50g, carry out according to embodiment 3 methods.
Embodiment 23: Oleum Viticis Negundo fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Viticis Negundo 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Viticis Negundo 50g, carry out according to embodiment 3 methods.
Embodiment 24: Oleum Rosae Rugosae fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Rosae Rugosae 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refining Oleum Rosae Rugosae 50g, carry out according to embodiment 3 methods.
Embodiment 25: ricinolein fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Ricini 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Get refined caster oil 50g, carry out according to the method for embodiment 3.
Embodiment 26: Oleum menthae fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Peppermint Oil 50 g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 27: oil of Herba Artemisiae Scopariae fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oil of Herba Artemisiae Scopariae 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 28: fennel oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fennel oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 29: Oleum Caryophylli fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Caryophylli 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 30: Oleum Anisi Stellati fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Anisi Stellati 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 31: Oleum thymi vulgaris fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum thymi vulgaris 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 32: Oleum Cinnamomi fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Cinnamomi 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 33: Oleum Folium Artemisiae Argyi fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Folium Artemisiae Argyi 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 34: Fructus Perillae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Perillae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 35: turmeric oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Turmeric oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Carry out according to embodiment 3 methods.
Embodiment 36: Cortex Melaleucae leucadendrae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Cortex Melaleucae leucadendrae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 37: Essential lavender oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Essential lavender oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 38: Radix Aucklandiae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Radix Aucklandiae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 39: patchouli oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Patchouli oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 40: Herba Verbenae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Herba Verbenae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 41: Common Wormwood oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Common Wormwood oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 42: Salvia Sclare L.oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Salvia Sclare L.oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Carry out according to embodiment 3 methods.
Embodiment 43: Rhizoma Atractylodis oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Rhizoma Atractylodis oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 44: Myrtus communis oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Myrtus communis oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 45: Fructus Citri Limoniae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Citri Limoniae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 46: Fructus Aurantii Immaturus oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Aurantii Immaturus oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 47: Fructus Amomi oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Amomi oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 48: Fructus Amomi oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Amomi oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 49: olive oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Olive oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 50: olive oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Olive oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 51: Oleum Pelargonii Graveolentis fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Pelargonii Graveolentis 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 52: Herba Moslae oils and fats fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Herba Moslae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 53: Oleum Menthae Rotundifoliae fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Menthae Rotundifoliae 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 54: Du Shan oils and fats fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Du Shan oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 55: oil of Ribes nigrum L. fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oil of Ribes nigrum L. 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 56: Fructus Schisandrae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Schisandrae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 57: Oleum lavandula angustifolia fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum lavandula angustifolia 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 58: Rhizoma Acori Graminei oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Rhizoma Acori Graminei oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml.
Method according to embodiment 3 is carried out.
Embodiment 59: Fructus Phellodendri oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Phellodendri oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 60: oleum bergamottae fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum bergamottae 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 61: sandal oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Sandal oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 62: Fructus Dauci Sativae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Dauci Sativae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 63: Cacumen Cupressi oil's fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
The 50g of Cacumen Cupressi oil
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 64: seed oil of Herba Apii graveolentis fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Seed oil of Herba Apii graveolentis 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 65: Herba Origani oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Herba Origani oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 66: Fructus Coriandri oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Fructus Coriandri oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 67: auradin fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Orange blossom oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 68: Semen Myristicae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Semen Myristicae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Carry out according to embodiment 3 methods.
Embodiment 69: oil of Bulbus Allii Cepae fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oil of Bulbus Allii Cepae 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 70: Oleum Santali albi fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Oleum Santali albi 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 71: Flos Tagetis Erectae oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Flos Tagetis Erectae oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 72: thyme oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Thyme oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 73: Cananga odorata oil fat emulsion oral or ejection preparation (5%, weight content)
Prescription:
Cananga odorata oil 50g
Soybean oil (injection) 50g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 3 is carried out.
Embodiment 74: Fructus Cnidii oil fat emulsion oral or ejection preparation (10%, weight content)
Prescription:
Fructus Cnidii oil 100g
Lecithin (injection) 12g
Glycerol 22g
Water for injection adds to 1000ml
Method according to embodiment 4 is carried out.
The foregoing description can also exemplify various, and the present invention utilizes the oil-soluble of medicine oil, and it is dissolved in the refined soybean oil, thereby makes the vegetable oil fat milk ejection preparation.Well solve the water solublity of vegetable oil, avoid the use of traditional cosolvent of side effect, can reduce the stimulation of medicine and cosolvent, improve drug effect, also replenished nutrition for patient to blood vessel.
Claims (4)
1. oral or ejection preparation of vegetable oil fat milk, it is characterized in that, oral or the ejection preparation of this vegetable oil fat milk is by medicinal plant oil, as the lecithin of emulsifying agent, as refined soybean oil or other refined oil, formulated as the glycerol and the water for injection of isoosmotic adjusting agent of oil-soluble diluent, and its consumption weight ratio is:
Medicinal plant oil 0.1%-30%;
Lecithin 5%-20% as emulsifying agent;
Refined soybean oil or other refined oil 0-30% as the oil-soluble diluent;
Glycerol 0.15%-0.25% as isoosmotic adjusting agent
Surplus is a water for injection; Be the 0.5-3 isotonic concentration wherein as the final osmotic pressure of the glycerol of isoosmotic adjusting agent.
2. the oral or ejection preparation of vegetable oil fat milk as claimed in claim 1 is characterized in that said medicinal plant oil is the fat-soluble medicine that can be dissolved in the refined oil, and they are:
Oleum Curcumae, Oleum Bulbus Allii, Rhizoma Chuanxiong oil, Herba Artemisiae Annuae oil, Oleum Hippophae, wintergreen oil, Radix Oenotherae erythrosepalae oil, Radix Angelicae Sinensis oil, oil of Rhizoma Zingiberis Recens, Herba Schizonepetae oil, Fructus Forsythiae oil, eucalyptus oil, perilla oil, Oleum Citri Reticulatae, Oleum Viticis Negundo, Oleum Rosae Rugosae, Oleum Ricini, Oleum menthae, oil of Herba Artemisiae Scopariae, fennel oil, pine oil, Oleum Caryophylli, Oleum Anisi Stellati, Oleum thymi vulgaris, Oleum Cinnamomi, Oleum Folium Artemisiae Argyi, Fructus Perillae oil, turmeric oil, Cortex Melaleucae leucadendrae oil, Essential lavender oil, Radix Aucklandiae oil, patchouli oil, Herba Verbenae oil, Common Wormwood oil, Salvia Sclare L.oil, Rhizoma Atractylodis oil, Myrtus communis oil, Fructus Citri Limoniae oil, Fructus Aurantii Immaturus oil, Oleum Ocimi Gratissimi, Folium Perillae oil, art pomegranate oil, Oleum Cocois, Fructus Amomi oil, olive oil, citronella oil, Oleum Pelargonii Graveolentis, Herba Moslae oil, Oleum Menthae Rotundifoliae, Du Shan oil, Herba Pogostemonis oil, Storax oil, oil of Ribes nigrum L., Fructus Schisandrae oil, Rhizoma Acori Graminei oil, Fructus Cnidii oil, Fructus Phellodendri oil, Oleum lavandula angustifolia, oil of rosemary, oleum bergamottae, sandal oil, Fructus Dauci Sativae oil, Cacumen Cupressi oil, seed oil of Herba Apii graveolentis, Herba Origani oil, citronellal oil, Fructus Coriandri oil, orange blossom oil, Semen Myristicae oil, oil of Bulbus Allii Cepae, Oleum Santali albi, Flos Tagetis Erectae oil, thyme oil, in the Cananga odorata oil any.
3. the oral or ejection preparation of vegetable oil fat milk as claimed in claim 1, it is characterized in that said lecithin as emulsifying agent is any of Ovum Gallus domesticus Flavus lecithin, soybean lecithin, hydrogenated yolk lecithin, hydrogenated soy phosphatidyl choline, synthetic lecithin.
4. the oral or ejection preparation of vegetable oil fat milk as claimed in claim 1, it is characterized in that said refined soybean oil or other refined oil as the oil-soluble diluent is in refined soybean oil, refined maize oil, refining Oleum Helianthi, refining Oleum Arachidis hypogaeae semen, refining Oleum sesami, the refining rapeseed oil any.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021394350A CN1186010C (en) | 2002-09-20 | 2002-09-20 | Vegetable oil fatty milk oral or injection preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021394350A CN1186010C (en) | 2002-09-20 | 2002-09-20 | Vegetable oil fatty milk oral or injection preparation |
Publications (2)
| Publication Number | Publication Date |
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| CN1483398A CN1483398A (en) | 2004-03-24 |
| CN1186010C true CN1186010C (en) | 2005-01-26 |
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| CNB021394350A Expired - Fee Related CN1186010C (en) | 2002-09-20 | 2002-09-20 | Vegetable oil fatty milk oral or injection preparation |
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Families Citing this family (21)
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| CN100560065C (en) * | 2005-02-02 | 2009-11-18 | 董英杰 | Asarone fat emulsion and preparation method thereof |
| CN1709398B (en) * | 2005-06-06 | 2012-02-15 | 沈阳药科大学 | Filtering-degerming Chinese medicine or animal-plant volatile oil or fat emulsion and preparing method |
| CN101006997B (en) * | 2006-01-26 | 2011-07-20 | 董英杰 | Compound taxol and its derivative docetaxel fat emulsion and preparation method |
| CN101380358B (en) * | 2008-10-14 | 2012-12-19 | 沈阳药科大学 | Perilla frutescens seed oil fat emulsion injection and preparation process |
| CN101816423A (en) * | 2010-04-22 | 2010-09-01 | 王京南 | Purple perilla seed oil lipid emulsion oral solution, beverage and manufacturing method thereof |
| CN101816422A (en) * | 2010-04-22 | 2010-09-01 | 王京南 | Oenothera biennise oil fat emulsion oral solution, drink and preparation method thereof |
| CN101843336A (en) * | 2010-04-22 | 2010-09-29 | 王京南 | Linseed oil fat emulsion oral solution, beverage and manufacturing method thereof |
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| CN102302099A (en) * | 2011-07-13 | 2012-01-04 | 智卫华 | Soy glyceride and preparation method thereof |
| CN102579580A (en) * | 2012-03-08 | 2012-07-18 | 西北农林科技大学 | Oil-in-water type compound ylang ylang oil nano-emulsion oral solution and preparation method thereof |
| CN104186706A (en) * | 2014-08-05 | 2014-12-10 | 汪芳 | Carrot seed sesame oil |
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| CN108721611A (en) * | 2018-04-23 | 2018-11-02 | 周华锋 | A kind of hydrophobic proteins enzyme oil formulation and its preparation method and application |
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