CN1899561A - Ginseng spleen strengthening oral solid preparation and its preparing method - Google Patents
Ginseng spleen strengthening oral solid preparation and its preparing method Download PDFInfo
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- CN1899561A CN1899561A CN 200610090248 CN200610090248A CN1899561A CN 1899561 A CN1899561 A CN 1899561A CN 200610090248 CN200610090248 CN 200610090248 CN 200610090248 A CN200610090248 A CN 200610090248A CN 1899561 A CN1899561 A CN 1899561A
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Abstract
The solid medicine preparation is prepared with prepared with 12 kinds of Chinese medicinal materials, including prepared rhubarb, ground beetle, leech, gadfly, white grub, etc in certain weight proportion. Its preparation process includes crushing all the materials, 80 mesh sieving, mixing, pelletizing while adding 50-70 % concentration syrup, drying at 60-80 deg.c, finishing, tabletting and coating. The preparation of the present invention has the functions of promoting blood circulation to disperse blood clots, dredging meridian passage and relieving distension and fullness.
Description
Technical field
The present invention relates to a kind of spleen strengthening oral preparation, relate in particular to a kind of ginseng spleen strengthening oral solid preparation and preparation technology's method thereof.
Background technology
Cause the diarrheal factor more, wherein to cause times of defecation to increase the most common because of dysfunction of spleen and stomach, and excrement matter is thin to be main symptom as water sample, and especially with infant below 3 years old or the old people sees that the age is more little or big more, sickness rate is higher.Primary disease belongs to modern medicine " dyspepsia " category.The traditional Chinese medical science thinks that diarrhoea mainly is being invaded by exogenous pathogen, and due to the reasons such as internal injury diet and weakness of the spleen and stomach, major lesions is at taste.Primary disease is obviously not seasonal, but sees with summer and autumn more.The traditional Chinese medical science is thought autumn in summer heat-damp in summer in season, easily the spleen and stomach being stranded by dampness and falling ill.Gas sweltering heat in autumn in summer, food is easy to go bad, and causes spleen injury after eating by mistake and suffers from diarrhoea.So my company begins to develop the ginseng spleen strengthening capsule, this product determined curative effect, domestic production producer is less, the volume of production deficiency, market demand is huge.Help medicine extensive use clinically, this project has the important social meaning.
The wherein insufficiency of the spleen a series of clinical symptoms that are meant that deficiency-weakness of spleen-QI or spleen YANG deficiency cause, main performance: gastral cavity abdomen tripe is full, lack of appetite is not changed, loose stool etc.Gas among the spleen master, its gas master liter, department's fortuneization stomach sum is fallen, and department is received.The taste deficiency-heat, abnormal ascending-descending of QI, superinverse is violated stomach, and stomach-QI being unable to descend normally is so promptly tell after vomiting and nausea anorexia or the food.Deficiency of spleen-QI, deficiency of QI in middle-JIAO, spirit is tired, the asthenia drowsiness.Taste are the source of vital function, weakness of the spleen and stomach, QI and blood source deficiency, then limbs fatigue.The traditional Chinese medical science is thought, the spleen being the foundation of acquired constitution, and source of generating QI and blood, spleen governing limbs muscle, close with movement relation.Show that in conjunction with modern medicine study spleen has the normal function of keeping internal organs and excites and strengthen vigour to resist the ability of pathogenic factor.
Vomiting is owing to stomach-QI being unable to descend normally, and adverse rising of stomach-QI consequently causes that food spues from mouth.Taste imbalances refers to spleen and stomach the exterior and the interior mutually, spleen master liter, and stomach the master fall, one rise and one drop, the maintenance mechanism of qi is unobstructed, makes essence of water and grain be failed cloth.If pathogen is violated stomach or insufficiency of stomach is become estranged.QI rising in reverse order and on, then vomit.Record in " Shengji Zonglu vomiting ": " vomiter does not descend not also on the gastric qi." weakness of the spleen and stomach: overwork, consumption damaging the spleen and stomach gas, or prolonged illness hypoactivity of YANG in middle-JIAO insufficiency of the spleenly can not bear water paddy, and essence of water and grain can not biochemical QI and blood, so that resistance and causing vomiting in cold turbid, or poly-and give birth to expectorant, amass in stomach, in the pathogenic fluid-retention superinverse, vomit.Also can lose its profit and fall, and cause vomiting because of deficiency of stomach-Yin.As saying in " card is controlled to converge and mended vomiting ": " deficiency of YIN becomes to vomit, and not only stomach man is a disease, and so-called depletion of YIN is then vomitted also." deficiency of spleen-QI and stomach-QI is many because of drinking and eating irregularly. work and rest mistake degree, or weakness due to chronic disease causes.Can cause human body shallow complexion, neurolysis, extremity asthenia, diseases such as loss of appetite, and disease such as how vexed with gastral cavity abdominal distention, dyspepsia, big loose stool be thin.Spleen has nutrient substance and the defeated water distribution liquid in the fortune relieving dyspepsia thing and has effect such as blood under one's command.Insufficiency of the spleen then dysfunction of the spleen in transportation and transformation, and malnutrition can occur, spleen plays crucial effect to the digestion and the absorption of food simultaneously, and therefore nearly all gastroenteropathy all can occur or with syndrome of spleen-deficiency.
Modern medicine is thought: the hypogenetic main cause of child is a dysfunction of spleen and stomach, poor appetite, and absorption difference causes the deficiency that absorbs nourishment, in this case.Mend manyly more, it also is useless that body does not absorb.Ginseng spleen strengthening oral solid preparation is the bridge block between the alimentation, and its effective active composition can promote the absorption of child's nutrition
Summary of the invention
In order to solve the problem of above-mentioned existence, the purpose of this invention is to provide a kind of evident in efficacyly, be free from side effects, have the oral solid formulation of air making-up and spleen enlivening, appetite-stimulating indigestion-relieving effect.
Technical scheme of the present invention is achieved in that a kind of ginseng spleen strengthening oral solid preparation, is made up of following raw materials in weight portion:
Radix Ginseng 5-140 part, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10-280 part, Radix Glycyrrhizae 5-140 part, Rhizoma Dioscoreae 18-420 part, Semen Nelumbinis 10-280 part, Semen Lablab Album 10-280 part, Radix Aucklandiae 2-105 part, Semen Alpiniae Katsumadai 5-140 part, Pericarpium Citri Reticulatae 10-280 part, Pericarpium Citri Reticulatae Viride (process with vinegar) 10-280 part, Massa Medicata Fermentata (parched with bran) 10-280 part, Fructus Setariae Germinatus (stir-fry) 10-280 part, Fructus Crataegi (stir-fry) 10-280 part, Semen Euryales (parched with bran) 10-280 part, Semen Coicis (parched with bran) 20-560 part, Radix Angelicae Sinensis 10-280 part, Fructus Aurantii (parched with bran) 5-140 part.
Preferably, a kind of ginseng spleen strengthening oral solid preparation of the present invention, form by following raw materials in weight portion:
Radix Ginseng 10-100 part, the Rhizoma Atractylodis Macrocephalae (parched with bran) 20-200 part, Radix Glycyrrhizae 10-100 part, Rhizoma Dioscoreae 30-300 part, Semen Nelumbinis 20-200 part, Semen Lablab Album 20-200 part, Radix Aucklandiae 4-80 part Semen Alpiniae Katsumadai 10-100 part, Pericarpium Citri Reticulatae 20-200 part, Pericarpium Citri Reticulatae Viride (process with vinegar) 20-200 part, Massa Medicata Fermentata (parched with bran) 20-200 part, Fructus Setariae Germinatus (stir-fry) 20-200 part, Fructus Crataegi (stir-fry) 20-200 part, Semen Euryales (parched with bran) 20-200 part, Semen Coicis (parched with bran) 40-400 part, Radix Angelicae Sinensis 20-200 part, Fructus Aurantii (parched with bran) 10-100 part.
Preferred, a kind of ginseng spleen strengthening oral solid preparation of the present invention, form by following raw materials in weight portion:
25 parts of Radix Ginsengs, 50 parts of the Rhizoma Atractylodis Macrocephalaes (parched with bran), 25 parts in Radix Glycyrrhizae, 75 parts of Rhizoma Dioscoreaes, 50 parts in Semen Nelumbinis, 50 parts of Semen Lablab Albums, 18.8 parts of the Radix Aucklandiae, 25 parts of Semen Alpiniae Katsumadai, 50 parts of Pericarpium Citri Reticulataes, 50 parts of Pericarpium Citri Reticulatae Viride (process with vinegar), 50 parts of Massa Medicata Fermentatas (parched with bran), 50 parts of Fructus Setariae Germinatuss (stir-fry), 50 parts of Fructus Crataegis (stir-fry), 50 parts of Semen Euryaless (parched with bran), 100 parts of Semen Coiciss (parched with bran), 50 parts of Radix Angelicae Sinensis, 25 parts of Fructus Aurantiis (parched with bran).
Another object of the present invention has provided a kind of method for preparing ginseng spleen strengthening oral solid preparation; May further comprise the steps:
A, Radix Ginseng, Massa Medicata Fermentata, Semen Alpiniae Katsumadai, corn sprout powder are broken into fine powder, cross 100 mesh sieves;
B, in the Radix Aucklandiae, Pericarpium Citri Reticulatae, add the Radix Aucklandiae, Pericarpium Citri Reticulatae gross weight 7-9 water doubly, soaked 0.5-1.5 hour, distill 3-5 hour extraction volatile oil; The decocting that adds 10-14 times of medicinal residues weight in medicinal residues boils once again, and the time is 1.5-3 hour, filters;
C, in Semen Lablab Album, Semen Euryales, Fructus Crataegi, Radix Glycyrrhizae, Semen Nelumbinis, Rhizoma Dioscoreae, Semen Coicis, add medicine gross weight 10-14 decocting doubly and boil, time is 2-4 hour, adds 12 water then in medicinal residues again, and decocting time is 1.5-3 hour, merge twice medicinal liquid, with medical filtration;
D, Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii are according to the percolation under fluid extract and the extractum item, 10 times of amounts of gross weight 50%-70% ethanol with Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii is made solvent, speed with per minute 3-8ml is carried out percolation, collects the liquid of filtering, and reclaims ethanol;
E, merge each medicinal liquid of above each step gained, be evaporated to the thick paste of relative density 1.40～1.45 (50 ℃);
The fine powder of f, the fine powder adding Radix Ginseng that in step e, adds step a, Massa Medicata Fermentata, Semen Alpiniae Katsumadai, Fructus Setariae Germinatus pulverizing, mixing dry below 60 ℃, is ground into fine powder, crosses 100 mesh sieves;
G, the volatile oil that extracts among the step b is dissolved in 300-500ml ethanol, is sprayed in the fine powder of step f, fully mixing incapsulates promptly.
This preparation also can be made other dosage forms, as long as add suitable excipient, by the corresponding preparation technology, makes oral solid formulation such as tablet, pill, drop pill or soft capsule etc.
The ginseng spleen strengthening capsule is a kind of effect digestant preferably.The treatment functional dyspepsia has significant curative effect.It can fully replenish the gastric juice composition, stimulates patient's appetite to increase, and obviously suppresses early full generation.It can promote the formation and the proteinic preliminary digestion of chyme effectively, helps making chyme to enter small intestinal from stomach.It has obviously shortened the gastric emptying time.Suppressed Upper abdominal pain strongly and feel sick, the generation of vomiting, and avoided belch, returned the appearance of acid.Observed result shows that the ginseng spleen strengthening capsule has significant curative effect to functional dyspepsia, and takes medicine conveniently, has no adverse reaction, and is easily accepted by the patient.Relapse rate is low after the drug withdrawal, has improved patient's quality of life after the treatment greatly.Use the ginseng spleen strengthening capsule after the recurrence again and still have curative effect preferably.
Pharmacological effect: Radix Ginseng, Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae have air making-up and spleen enlivening, and multiple middle Jiao's strong fortune is monarch drug; Semen Euryales, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Semen Lablab Album, Pericarpium Citri Reticulatae Viride have the spleen invigorating circulation of qi promoting, removing dampness by means of aromatics, make monarch drug mend and do not disappear and monarch drug together Zhi Qiben be ministerial drug; Massa Medicata Fermentata, Fructus Setariae Germinatus, Fructus Crataegi consumer product dredge stasis remove and have stopped amassing, the Chinese angelica blood supplementing QI invigorating, and the Fructus Aurantii heat clearing and damp drying, Semen Alpiniae Katsumadai astringing to arrest diarrhea and Massa Medicata Fermentata, Fructus Setariae Germinatus etc. are controlled its mark together, are adjuvant drug altogether.All medicines share, and disappear to mend to walk abreast, and then middle burnt strong fortune stagnates and eliminated.
Function with cure mainly: air making-up and spleen enlivening, appetite-stimulating indigestion-relieving.Be used for the anorexia and loose stool due to the stagnation of dampness due to deficiency of the spleen, or tell or rush down distension and fullness in the abdomen, limbs fatigue, diseases such as shallow complexion.
Usage and consumption: specification be every adorn 0.25 the gram, oral, one time 4,2 times on the one.
Compared with prior art the invention has the beneficial effects as follows: manufacture method is simple, taking convenience, and therapeutic effect is remarkable, does not have toxic and side effects.
Functional dyspepsia is to be main performance with the inappetence, with or without upper abdominal pain, belch, return acid, feel sick, symptom such as vomiting, get rid of a kind of disease that organic disease causes, this disease often lasts for several years even many decades, outbreak repeatedly, weight person can have a strong impact on patients ' life quality, cause become thin, weak, anemia, make the patient can not orthobiosis.By the ailing torment time longer, also can cause depression, even commit suiside.My institute's ginseng spleen strengthening capsule for treating 180 routine patients with functional dyspepsia, evident in efficacy through clinical observation, improved quality of life of patient greatly.
1 clinical data
1.1 180 examples are organized in the physical data treatment, wherein male 51 examples, women 129 examples, the oldest 78 years old, minimum 15 years old, average 55.8 years old.Matched group 90 examples, wherein male 27 examples, women 63 examples, the oldest 72 years old, minimum 23 years old, average 51.3 years old.Two groups of patient's sexes, age, the state of an illness, the course of disease are roughly the same, have comparability.
1.2 method treatment group is used the ginseng spleen strengthening capsule, each 4,2 times on the one, all uses at taking medicine before meal.Matched group is taken polyzyme tablets, every day 3 times, each 2, all uses at taking medicine before meal.Follow up a case by regular visits to its symptom variation in the therapeutic process, observe having no adverse reaction.And advise the patient during observing treatment, do not take other any digestants.1 month is 1 course of treatment.
1.3 result
79 examples (43.9%) 1.3.1 relatively treatment group of total effective rate is fully recovered, produce effects 83 examples (46.1%), 18 examples that take a turn for the better (10%), invalid 0 example (0%), effective percentage 100%.Matched group 33 examples (36.7%) of fully recovering, produce effects 27 examples (30%), 18 examples that take a turn for the better (22%), invalid 12 examples (13.3%), effective percentage is 66.7%, treatment group effective percentage is higher than matched group (P＜0.01).
Back appetite is recovered 1.3.2-clinicing symptom observation treatment group is taken medicine, belch, return acid, feel sick, vomiting, early simultaneous phenomenon such as full takes a turn for the better, recurrence after the drug withdrawal, improve the difference that significance is arranged before and after treatment: and have only nauseating, two kinds of symptom treatments front and back of vomiting significant difference in the matched group.Two groups relatively there were significant differences (P＜0.01).
1, two groups of patients of 3.3 untoward reaction all have no adverse reaction in the drug application process.
Infantile anorexia is the clinical common frdquently encountered disease of department of pediatrics I, treat often thorny, in clinical with
Drug therapy of the present invention is for infantile anorexia, and satisfactory effect now is reported as follows
1 clinical data
158 examples are the outpatient service infant, are diagnosed as infantile anorexia according to its clinical manifestation and blood zinc check result.158 routine infants are divided into two groups at random, and treatment group 88 is fallen, matched group 70 examples, and learning two groups of infants of processing equal no significant difference (P＞0.05) by statistics all has inappetence or anorexia in various degree; The normal youngster's slight of stature of body, body weight is lower than normal youngster person, and 82 examples are organized in treatment. matched group 60 examples; The normal person of spirit.Treatment group 65 is fallen, and matched group 58 falls; Hypotrichosis is turned to be yellow or is knotted as fringe, and 53 examples are organized in treatment, matched group 25 examples, and xerostomia is liked drinking-water yearningly, xerosis cutis person, 75 examples are organized in treatment, matched group 62 examples; Easy sweating easy catching a cold person, treatment group 28 is fallen matched group 35 examples.
2 Therapeutic Method
2.1 treatment group utilization ginseng spleen strengthening capsule cooperates child massage.
Instructions of taking: oral, one time 4, (every adorn 0.25 gram), 2 times on the one, treating for 4 weeks continuously is a course of treatment, can treat 1～3 course of treatment according to the state of an illness.
2.1.2 massage therapy: push away spleen channel, stomach warp, plate door, contrary fortune Eight Diagrams, rub the middle part of gastric cavity, the abdomen that rubs, take tripe angle, chiropractic, an order once, treating 15 days is a course of treatment, stops 5 days, carries out for second course of treatment again, can treat continuously for 2～3 courses of treatment.
2.2 matched group gives conventional zinc sulfate, yeast tablet is oral, the course of treatment is identical.
3 results
3.1 criterion of therapeutical effect: all treat 1～3 course of treatment, if appetite is often become a full member, weight increase is looked into serum zinc＞110umol/L and is recovery from illness; Appetite obviously increases other sings and symptomses and obviously improves, and looking into serum zinc＞100umol/L is produce effects; Appetite does not have symptom such as preceding after obvious improvement or the drug withdrawal, and it is invalid looking into serum zinc＜90umol/L
3.2 therapeutic outcome; 1. relatively and by statistics learn processing to treating healing 1～3 course of treatment situation, P≤0.01 has the highly significant meaning 2. to the total effects evaluation relatively, learns by statistics and handles, and there is the highly significant meaning P≤0.01.
The specific embodiment
Below in conjunction with specific embodiment the present invention is described in further detail, but not as a limitation of the invention.
A kind of ginseng spleen strengthening oral solid preparation, filling a prescription is: Radix Ginseng 25g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 50g, Radix Glycyrrhizae 25g, Rhizoma Dioscoreae 75g, Semen Nelumbinis 50g, Semen Lablab Album 50g, Radix Aucklandiae 18.8g, Semen Alpiniae Katsumadai 25g, Pericarpium Citri Reticulatae 50g, Pericarpium Citri Reticulatae Viride (process with vinegar) 50g, Massa Medicata Fermentata (parched with bran) 50g, Fructus Setariae Germinatus (stir-fry) 50g, Fructus Crataegi (stir-fry) 50g, Semen Euryales (parched with bran) 50g, Semen Coicis (parched with bran) 100g Radix Angelicae Sinensis 50g, Fructus Aurantii (parched with bran) 25g.
A kind of method for preparing ginseng spleen strengthening oral solid preparation; May further comprise the steps:
A, 25g Radix Ginseng, 50g Massa Medicata Fermentata (parched with bran), 25g Semen Alpiniae Katsumadai, 50g Fructus Setariae Germinatus (stir-fry) are ground into fine powder, cross 100 mesh sieves;
B, in the 18.8g Radix Aucklandiae, 50g Pericarpium Citri Reticulatae, add the water of 550.4g, soaked 1 hour, distill 4 hours extraction volatile oil; The decocting that adds 12 times of medicinal residues weight in medicinal residues boils once again, and the time is 2 hours, filters and extracts medicinal liquid;
C, the decocting that adds 4800g in 50g Semen Lablab Album, 50g Semen Euryales, 50g Fructus Crataegi, 25g Radix Glycyrrhizae, 50g Semen Nelumbinis, 75g Rhizoma Dioscoreae, 100g Semen Coicis boil, time is 3 hours, adds 4800g water then in medicinal residues again, and decocting time is 2 hours, merge twice medicinal liquid, with medical filtration;
D, 50g Pericarpium Citri Reticulatae Viride, 50g Radix Angelicae Sinensis, the 50g Rhizoma Atractylodis Macrocephalae, 25g Fructus Aurantii make solvent according to the percolation under fluid extract and the extractum item with 60% ethanol of 1750g, carry out percolation with the speed of per minute 5ml, collect the liquid of filtering, and reclaim ethanol simultaneously;
E, merge each medicinal liquid of above each step gained, be evaporated to the thick paste of relative density 1.40～1.45 (50 ℃);
The fine powder of f, the fine powder adding Radix Ginseng that in step e, adds step a, Massa Medicata Fermentata, Semen Alpiniae Katsumadai, Fructus Setariae Germinatus pulverizing, mixing dry below 60 ℃, is ground into fine powder, crosses 100 mesh sieves;
G, the volatile oil that extracts among the step b is dissolved in 400ml ethanol, is sprayed in the fine powder of step f, abundant mixing is in incapsulating, promptly.
Claims (5)
1. ginseng spleen strengthening oral solid preparation is characterized in that being made up of following raw materials in weight portion:
Radix Ginseng 5-140 part, Rhizoma Atractylodis Macrocephalae 10-280 part, Radix Glycyrrhizae 5-140 part, Rhizoma Dioscoreae 18-420 part, Semen Nelumbinis 10-280 part, Semen Lablab Album 10-280 part, Radix Aucklandiae 2-105 part, Semen Alpiniae Katsumadai 5-140 part, Pericarpium Citri Reticulatae 10-280 part, Pericarpium Citri Reticulatae Viride 10-280 part, Massa Medicata Fermentata 10-280 part, Fructus Setariae Germinatus 10-280 part, Fructus Crataegi 10-280 part, Semen Euryales 10-280 part, Semen Coicis 20-560 part, Radix Angelicae Sinensis 10-280 part, Fructus Aurantii 5-140 part.
2, a kind of ginseng spleen strengthening oral solid preparation according to claim 1 is characterized in that wherein the weight proportion of each raw material is:
Radix Ginseng 10-100 part, Rhizoma Atractylodis Macrocephalae 20-200 part, Radix Glycyrrhizae 10-100 part, Rhizoma Dioscoreae 30-300 part, Semen Nelumbinis 20-200 part, Semen Lablab Album 20-200 part, Radix Aucklandiae 4-80 part, Semen Alpiniae Katsumadai 10-100 part, Pericarpium Citri Reticulatae 20-200 part, Pericarpium Citri Reticulatae Viride 20-200 part, Massa Medicata Fermentata 20-200 part, Fructus Setariae Germinatus 20-200 part, Fructus Crataegi 20-200 part, Semen Euryales 20-200 part, Semen Coicis 40-400 part, Radix Angelicae Sinensis 20-200 part, Fructus Aurantii 10-100 part.
3, a kind of ginseng spleen strengthening oral solid preparation according to claim 1 is characterized in that wherein the weight proportion of each raw material is:
25 parts of Radix Ginsengs, 50 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts in Radix Glycyrrhizae, 75 parts of Rhizoma Dioscoreaes, 50 parts in Semen Nelumbinis, 50 parts of Semen Lablab Albums, 18.8 parts of the Radix Aucklandiae, 25 parts of Semen Alpiniae Katsumadai, 50 parts of Pericarpium Citri Reticulataes, 50 parts on Pericarpium Citri Reticulatae Viride, 50 parts of Massa Medicata Fermentatas, 50 parts of Fructus Setariae Germinatuss, 50 parts of Fructus Crataegis, 50 parts of Semen Euryaless, 100 parts of Semen Coiciss, 50 parts of Radix Angelicae Sinensis, 25 parts of Fructus Aurantiis.
4,, it is characterized in that described preparation is capsule, tablet, pill, drop pill or soft capsule according to claim 1,2 or 3 described a kind of ginseng spleen strengthening oral solid preparations.
5, a kind of method for preparing ginseng spleen strengthening oral solid preparation; It is characterized in that may further comprise the steps:
A, Radix Ginseng, Massa Medicata Fermentata, Semen Alpiniae Katsumadai, corn sprout powder are broken into fine powder, cross 100 mesh sieves;
B, in the Radix Aucklandiae, Pericarpium Citri Reticulatae, add the Radix Aucklandiae, Pericarpium Citri Reticulatae gross weight 7-9 water doubly, soaked 0.5-1.5 hour, distill 3-5 hour extraction volatile oil; The decocting that adds 10-14 times of medicinal residues weight in medicinal residues boils once again, and the time is 1.5-3 hour, filters;
C, in Semen Lablab Album, Semen Euryales, Fructus Crataegi, Radix Glycyrrhizae, Semen Nelumbinis, Rhizoma Dioscoreae, Semen Coicis, add medicine gross weight 10-14 decocting doubly and boil, time is 2-4 hour, adds 12 water then in medicinal residues again, and decocting time is 1.5-3 hour, merge twice medicinal liquid, with medical filtration;
D, Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii are according to the percolation under fluid extract and the extractum item, 10 times of amounts of gross weight 50%-70% ethanol with Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii is made solvent, speed with per minute 3-8ml is carried out percolation, collects the liquid of filtering, and reclaims ethanol;
E, merge each medicinal liquid of above each step gained, be evaporated to the thick paste of relative density 1.40～1.45 (50 ℃);
The fine powder of f, the fine powder adding Radix Ginseng that in step e, adds step a, Massa Medicata Fermentata, Semen Alpiniae Katsumadai, Fructus Setariae Germinatus pulverizing, mixing dry below 60 ℃, is ground into fine powder, crosses 100 mesh sieves;
G, the volatile oil that extracts among the step b is dissolved in 300-500ml ethanol, is sprayed in the fine powder of step f, fully mixing incapsulates promptly.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191358A (en) * | 2013-04-19 | 2013-07-10 | 浙江维康药业有限公司 | Pharmaceutical composition for invigorating qi and strengthening spleen |
| CN103431466A (en) * | 2013-08-01 | 2013-12-11 | 钟永祥 | Ginseng solid beverage and preparation method thereof |
| CN105853862A (en) * | 2016-04-28 | 2016-08-17 | 韩志强 | Ginseng tablet capable of strengthening spleen and preparation method thereof |
| CN109043272A (en) * | 2018-08-23 | 2018-12-21 | 厦门华言科技有限公司 | Oyster joins peptide solid beverage and preparation method thereof |
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2006
- 2006-07-07 CN CN 200610090248 patent/CN1899561A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191358A (en) * | 2013-04-19 | 2013-07-10 | 浙江维康药业有限公司 | Pharmaceutical composition for invigorating qi and strengthening spleen |
| CN103431466A (en) * | 2013-08-01 | 2013-12-11 | 钟永祥 | Ginseng solid beverage and preparation method thereof |
| CN105853862A (en) * | 2016-04-28 | 2016-08-17 | 韩志强 | Ginseng tablet capable of strengthening spleen and preparation method thereof |
| CN109043272A (en) * | 2018-08-23 | 2018-12-21 | 厦门华言科技有限公司 | Oyster joins peptide solid beverage and preparation method thereof |
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