CN1895362A - Shuanghuanglian soft extract and preparation method thereof - Google Patents
Shuanghuanglian soft extract and preparation method thereof Download PDFInfo
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- CN1895362A CN1895362A CN 200610010141 CN200610010141A CN1895362A CN 1895362 A CN1895362 A CN 1895362A CN 200610010141 CN200610010141 CN 200610010141 CN 200610010141 A CN200610010141 A CN 200610010141A CN 1895362 A CN1895362 A CN 1895362A
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- 238000000605 extraction Methods 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 68
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Abstract
The invention relates to a Shuanghuanglian soft extract and a preparation method thereof, which consists of the following raw materials: honeysuckle, scutellaria, forsythia, honey or invert sugar. The preparation method comprises the steps of decocting, filtering, concentrating, carrying out acid treatment, standing, washing with water, washing with alcohol and the like on scutellaria baicalensis to prepare a scutellaria baicalensis extract, adding the scutellaria baicalensis extract into clear paste prepared by decocting honeysuckle and fructus forsythiae, carrying out alcohol precipitation, concentrating to the temperature of 80 ℃, wherein the relative density is 1.20-1.25, uniformly mixing, weighing, adding refined honey or invert sugar which is not more than 3 times of the total weight of the clear paste, heating with slow fire, uniformly mixing and filling. The invention is characterized by nourishing effect while curing diseases, high concentration, large content, fast dissolving, easy absorption, stable quality, convenient preservation, curing chronic diseases and having the functions of anti-aging and prolonging life.
Description
Affiliated field:
The present invention relates to a kind of SHUANGHUANLIAN soft extract and preparation method thereof.
Background technology:
Modern pharmacology studies show that 'Shuang Hualian ' can resist multiple pathogenic microorganism, has the broad-spectrum bactericidal action; And can reduce the permeability of blood capillary, minimizing is oozed out, and has antiinflammatory, anti-allergic effects; Also but enhancing body produces the alpha-interferon ability, can strengthen cellular immunization and humoral immunization effect significantly, antagonism virus also has stronger inhibitory action, and the bacteriogenic endotoxin that can neutralize, while tool infection and immune dual function, clinically be mainly used in the flu that antibacterial and viral infection cause, influenza and pneumonia, tracheitis, diseases such as tonsillitis, its determined curative effect, safety, effectively, present SHUANGHUANGLIAN KELI, SHUANGHUANGLIAN KOUFUYE, SHUANGHUANGLIAN PIAN, SHUANGHUANGLIAN FENZHENJI, SHUANGHUANLIAN syrup etc. is widely used in clinical, and determined curative effect, at present domestic not production of SHUANGHUANLIAN soft extract and preparation, be soft extract, soft extract is the succession of traditional medicine technology, at defying age, health care, all unique characteristics in the treatment chronic disease are suitable for chronic patient to be taken for a long time.
Summary of the invention:
The object of the present invention is to provide a kind of preparation method that leaches medicine quality height, is suitable for the SHUANGHUANLIAN soft extract of chronic patient treatment.
This medicine is made by following materials of weight proportions:
Flos Lonicerae 500～1500g Radix Scutellariae 500～1500g Fructus Forsythiae 1000～3000g
Adjuvant: Mel adjuvant addition: 600g～1500g
Preparation method of the present invention is: Radix Scutellariae decocts with water 3 times, 2 hours first time, second and third time each 1 hour, collecting decoction, filter, filtrate is concentrated into 80 ℃ of temperature, relative density 1.05～1.10, in the time of 80 ℃, add the 2mol/L hydrochloric acid solution and regulate pH value to 1.0～2.0, be incubated 1 hour, left standstill 24 hours, filter, precipitation washes with water to pH value 5.0, continuing and being washed till pH value with 70% ethanol is 7.0, cold drying, and it is standby to be ground into fine powder; Flos Lonicerae, after Fructus Forsythiae adds water temperature and soaks half an hour, decoct secondary, each 1.5 hours, gradation filters, and merging filtrate is concentrated into 70～80 ℃ of temperature, relative density is 1.20～1.25 clear paste, when being chilled to 40 ℃, slowly adds ethanol under stirring, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stirs evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol and do not distinguish the flavor of to there being alcohol, and be concentrated into 80 ℃ of temperature, relative density is 1.20～1.25 clear paste, add above-mentioned Radix Scutellariae extract, mix homogeneously claims to decide weight, adds Mel, the heating mix homogeneously, fill promptly.
Advantage of the present invention is:
1. this product preparation has kept the Chinese medicine characteristic, group's conventional practice that medicine is fried in shallow oil altogether, slow fire is carefully fried in shallow oil, it is the succession of traditional medicine technology, it can be added and subtracted with disease, prescription is flexible, departing from the medication of Chinese medicine custom, the drug level height, content is big, dissolving is fast, easily absorption, steady quality, be convenient to preserve, under the prerequisite that guarantees curative effect, kept traditional medication custom again.
2. be suitable for chronic patient to be taken for a long time, medicine is dense, amount is little, take after mixing it with water convert clothes all can, reduced the bitter taste of drug mouthfeel, to the patient of chronic disease is arranged, be more suitable for this dosage form of taking for a long time.
3. because of this product is a soft extract, in compounding process, directly in the extractum that extracts, add adjuvant, get final product the fill finished product after the heating mix homogeneously, the process that has not had the dry of former granule and granulated no matter be aspect energy resource consumption or preparation technology's complexity, all is better than granule.
4. need not before the present invention takes to decoct, dosage is accurate, and taking convenience meets national every pharmaceutical control law regulation.
5. the present invention is a kind of of 'Shuang Hualian ', has the effect of relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing, can be used for heating that affection due to external wind and heat causes, cough, pharyngalgia etc., has the effect that vital base and primordial QI consolidating, nourishing are in harmonious proportion when curing the disease concurrently.
6. do not add any antiseptic in this preparation.
7. 'Shuang Hualian ' exact efficacy clinically, the report with the 'Shuang Hualian ' clinical test results is summarized as follows below:
Description of drawings
Fig. 1 is two groups sex, an age distribution information slip
Fig. 2 is that disease is planted distribution table
Fig. 3 is treatment group, contrast groups curative effect comparison sheet
Fig. 4 is that treatment group, contrast groups symptom and sign are recovered normal time relatively
The specific embodiment:
The present invention is the preparation method of a kind of 'Shuang Hualian '-SHUANGHUANLIAN soft extract, below enforcement of the present invention is described in further detail.
Embodiment 1
Flos Lonicerae 500g Radix Scutellariae 500g Fructus Forsythiae 1000g
Adjuvant: Mel 600g
Preparation method: Radix Scutellariae decocts with water 3 times, 2 hours first time, second and third time each 1 hour, collecting decoction, filter, filtrate is concentrated into 80 ℃ of temperature, relative density 1.05～1.10, in the time of 80 ℃, add the 2mol/L hydrochloric acid solution and regulate pH value to 1.0～2.0, be incubated 1 hour, left standstill 24 hours, filter, precipitation washes with water to pH value 5.0, continuing and being washed till pH value with 70% ethanol is 7.0, cold drying, and it is standby to be ground into fine powder; Flos Lonicerae, after Fructus Forsythiae adds water temperature and soaks half an hour, decoct secondary, each 1.5 hours, gradation filters, and merging filtrate is concentrated into 70～80 ℃ of temperature, relative density is 1.20～1.25 clear paste, when being chilled to 40 ℃, slowly adds ethanol under stirring, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stirs evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol and do not distinguish the flavor of to there being alcohol, and be concentrated into 80 ℃ of temperature, relative density is 1.20～1.25 clear paste, add above-mentioned Radix Scutellariae extract, mix homogeneously claims to decide weight, adds Mel, the heating mix homogeneously, fill promptly.
Flos Lonicerae 1000g Radix Scutellariae 1000g Fructus Forsythiae 2000g
Adjuvant: Mel 725g
Preparation method: Radix Scutellariae decocts with water 3 times, 2 hours first time, second and third time each 1 hour, collecting decoction, filter filtrate thickening temperature to 80 ℃, relative density 1.05～1.10, in the time of 80 ℃, add the 2mol/L hydrochloric acid solution and regulate pH value to 1.0～2.0, be incubated 1 hour, left standstill 24 hours, filter, precipitation washes with water to pH value 5.0, continuing and being washed till pH value with 70% ethanol is 7.0, cold drying, and it is standby to be ground into fine powder; Flos Lonicerae, after Fructus Forsythiae adds water temperature and soaks half an hour, decoct secondary, each 1.5 hours, gradation filters, and merging filtrate is concentrated into 70～80 ℃, relative density is 1.20～1.25 clear paste, when being chilled to 40 ℃, slowly adds ethanol under stirring, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stirs evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, and thickening temperature to 80 ℃, relative density is 1.20～1.25 clear paste, add above-mentioned Radix Scutellariae extract, mix homogeneously claims to decide weight, adds Mel, the heating mix homogeneously, fill promptly.
Flos Lonicerae 1500g Radix Scutellariae 1500g Fructus Forsythiae 3000g
Adjuvant: Mel 1500g
Preparation method: Radix Scutellariae decocts with water 3 times, 2 hours first time, second and third time each 1 hour, collecting decoction, filter, filtrate is concentrated into relative density 1.05～1.10 (80 ℃ of surveys), adds the 2mol/L hydrochloric acid solution and regulate pH value to 1.0～2.0 in the time of 80 ℃, is incubated 1 hour, left standstill 24 hours, filter, precipitation washes with water to pH value 5.0, and continuing and being washed till pH value with 70% ethanol is 7.0, cold drying, it is standby to be ground into fine powder; Flos Lonicerae, after Fructus Forsythiae adds water temperature and soaks half an hour, decoct secondary, each 1.5 hours, gradation filters, and merging filtrate is concentrated into 70～80 ℃ of temperature, relative density is 1.20～1.25 clear paste, when being chilled to 40 ℃, slowly adds ethanol under stirring, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stirs evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol and do not distinguish the flavor of to there being alcohol, and be concentrated into 80 ℃ of temperature, relative density is 1.20～1.25 clear paste, add above-mentioned Radix Scutellariae extract, mix homogeneously claims to decide weight, adds Mel, the heating mix homogeneously, fill promptly.
[character] this product is the stiff semifluid of rufous; It is sweet to distinguish the flavor of, little hardship.
The 90 routine infants that physical data will meet the case standard are divided into treatment group 50 examples and matched group 40 examples at random, and two groups of patients' sex, age course of disease distribution situation are seen Fig. 1, Fig. 2.
Two groups of patient data differences do not have significance (P＜0.05).
Therapeutic Method: the treatment group gives SHUANGHUANGLIAN KOUFUYE,＜5 years old each 1/2, twice of every day; Matched group gives virazole 10mg/kg.d, and is oral.Two groups of equal logotype 5-7d, two groups of other Primary Cares are identical, all without other antiviral drugs.
Efficacy determination: cure: body temperature is normal, the disappearance of panting, and pulmonary's hello sound disappears.Take a turn for the better: body temperature is normal, pants to be clearly better, and pulmonary's hello sound reduces.Invalid: the state of an illness does not have improvement or increases the weight of.
Statistical procedures: measurement data is so that (x ± s) expression adopts x
2Check or t check.
The result: two groups of curative effects are relatively seen Fig. 3.
The result shows that the treatment group is better than matched group (P＜0.05)
Two groups of symptoms, signs are recovered normal time and are relatively seen Fig. 4.
Compare with matched group: * P＜0.05 * * P＜0.01
By top statistical result as can be known, treatment group symptom and sign recovery normal time is significantly shorter than matched group.'Shuang Hualian ' can be accelerated alleviation and generate heat, pants, coughs and quicken to absorb pulmonary's hello sound.
This product 3g is got in [discriminating] (1), adds 75% ethanol 30ml, puts in the water-bath heating jolting and makes dissolving, filters, and filtrate is as need testing solution.Other gets baicalin reference substance, chlorogenic acid reference substance, add 75% ethanol respectively and make the solution that every 1ml contains 0.1mg, product solution according to thin chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B) test, is drawn each 1～2ul of above-mentioned three kinds of solution in contrast, put in same polyamide film (on the 5cm * 7cm) respectively, with acetic acid is developing solvent, launches, and takes out, dry, put under the ultraviolet light (365nm) and inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color.
(2) get this product 1.5g, add methanol 30ml, put in the water-bath heating and make dissolving, filter, filtrate is as need testing solution.Other gets Fructus Forsythiae control medicinal material 0.5g, adds methanol 10ml, and reflux 20 minutes filters, and filtrate is medical material solution in contrast.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B), draw each 5 μ l of above-mentioned two kinds of solution, put respectively in same be on the silica gel g thin-layer plate of binding agent with the sodium carboxymethyl cellulose, with chloroform-methanol (5: 1) is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, 105 ℃ of heating several minutes.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
[inspection] relative density should be not less than 1.25 (an appendix I of Chinese Pharmacopoeia version in 2005 F)
Other should meet every regulation relevant under the soft extract item (appendix I F)
[assay]
Radix Scutellariae is measured according to high performance liquid chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 D).
Chromatographic condition and system suitability test are filler with the octadecylsilane chemically bonded silica; With methanol-water-glacial acetic acid (50: 50: 1) is mobile phase; The detection wavelength is 274nm.Number of theoretical plate calculates by the baicalin peak should be not less than 1500.
It is an amount of that the baicalin reference substance is got in the preparation of reference substance solution, and accurate the title decides, and adds 50% methanol and makes the solution that every 1ml contains 0.1mg, promptly.
The preparation precision of need testing solution is measured this product 1g, puts in the 50ml measuring bottle, and it is an amount of to add 50% methanol, and supersound process 20 minutes is placed to room temperature, adds 50% methanol and is diluted to scale, shakes up, promptly.
Accurate respectively reference substance solution and each the 10 μ l of need testing solution of drawing of algoscopy,, inject chromatograph of liquid, measure, promptly.
The every 1g of this product contains baicalin (C
21H
18O
11) meter, must not be less than 10.7mg.
[function with the cure mainly] wind, relieving exterior syndrome that relaxes, heat-clearing and toxic substances removing.Be used for the flu due to the affection due to external wind and heat, disease is seen heating, cough, pharyngalgia.
[usage and consumption] is oral, a 15g, 3 times on the one; Children's is cut down according to the circumstance or is followed the doctor's advice.
[storage] sealing, lucifuge is put shady and cool place.
Claims (3)
1, a kind of preparation method of golden thread decoction plaster is characterized in that: this medicine is made by following materials of weight proportions:
Flos Lonicerae 500～1500g Radix Scutellariae 500～1500g Fructus Forsythiae 1000～3000g
Adjuvant: Mel adjuvant addition: 600g～1500g
2, according to claim 1 it is characterized in that: described dosage form is a soft extract.
3, the preparation method of SHUANGHUANLIAN soft extract according to claim 1 is characterized in that: Radix Scutellariae decocts with water 3 times, 2 hours first time, second and third time each 1 hour, collecting decoction filters, and filtrate is concentrated into 80 ℃ of temperature, relative density 1.05～1.10 adds the 2mol/L hydrochloric acid solution and regulates pH value to 1.0～2.0 in the time of 80 ℃, be incubated 1 hour, left standstill 24 hours, filter, precipitation washes with water to pH value 5.0, and continuing and being washed till pH value with 70% ethanol is 7.0, cold drying, it is standby to be ground into fine powder; Flos Lonicerae, after Fructus Forsythiae adds water temperature and soaks half an hour, decoct secondary, each 1.5 hours, gradation filters, and merging filtrate is concentrated into 70～80 ℃ of temperature, relative density is 1.20～1.25 clear paste, when being chilled to 40 ℃, slowly adds ethanol under stirring, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stirs evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol and do not distinguish the flavor of to there being alcohol, and be concentrated into 80 ℃ of temperature, relative density is 1.20～1.25 clear paste, add above-mentioned Radix Scutellariae extract, mix homogeneously claims to decide weight, adds Mel, the heating mix homogeneously, fill promptly.
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| CN 200610010141 CN1895362A (en) | 2006-06-12 | 2006-06-12 | Shuanghuanglian soft extract and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653550A (en) * | 2018-07-10 | 2018-10-16 | 天长亿帆制药有限公司 | A kind of fiber crops a kind of reed mentioned in ancient books disappears cough drug and preparation method thereof and detection method |
| CN115645364A (en) * | 2022-11-09 | 2023-01-31 | 江苏南京农大动物药业有限公司 | Shuanghuanglian oral liquid for pets |
-
2006
- 2006-06-12 CN CN 200610010141 patent/CN1895362A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653550A (en) * | 2018-07-10 | 2018-10-16 | 天长亿帆制药有限公司 | A kind of fiber crops a kind of reed mentioned in ancient books disappears cough drug and preparation method thereof and detection method |
| CN115645364A (en) * | 2022-11-09 | 2023-01-31 | 江苏南京农大动物药业有限公司 | Shuanghuanglian oral liquid for pets |
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