CN1891295A - Method for preparing liquid medicine preparation for further promoting intrinsic quality - Google Patents
Method for preparing liquid medicine preparation for further promoting intrinsic quality Download PDFInfo
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- CN1891295A CN1891295A CN 200510080826 CN200510080826A CN1891295A CN 1891295 A CN1891295 A CN 1891295A CN 200510080826 CN200510080826 CN 200510080826 CN 200510080826 A CN200510080826 A CN 200510080826A CN 1891295 A CN1891295 A CN 1891295A
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Abstract
The present invention relates to a preparation method capable of further raising intrior quality of liquid medicine preparation. It is characterized by that said invention utilizes three processes of ultrasonication, far-infrared energization and magnetization treatment to activate liquid medicine, and utilizes most economic mode to maximally introduce the magnetized water, small micelle water and high energy water into the liquid medicine preparation of industrial production, so that it can greatly raise the quality of liquid medicine preparation.
Description
Technical field
The present invention relates to the preparation method of a kind of drug formulation process, particularly liquid pharmaceutical formulation, belong to field of pharmaceutical preparations.
Background technology
Ancients' water for pharmaceutical purposes is fastidious especially:
Record 43 kinds of water altogether in Compendium of Materia Medica water portion the 5th volume, wherein one of water sky and water class is recorded 13 kinds, and two ground water classes of water are recorded 30 kinds.Mainly the angle and the state of an illness from the yin-yang and five elements of water is complementary, and being has deep intension that its most of moderns are confused about.
The modern has following understanding with the angle of science to water:
Hydrone has memory: when the snowflake crystal that will have difformity and weight individually as scientist dissolves respectively and then freezes again, just the same before finding crystalline shape of snowflake and the weight freeze again and dissolving, the conclusion of " memory " must water outlet itself be arranged.
Because hydrone itself has its special planform, it is with certain special angle be combined into by two hydrogen and an oxonium ion.It is a kind of ionizing system that has electronics " magnetic polarity ", so we can regard the shape of fluid water molecule as " liquid crystal ".Hydrone presents solid-state crystalline solid at zero degree and subzero, and we are referred to as ice.Yet water is not to present aqueously fully to 60 ℃ the temperature zero, but exists with the crystalline form of a kind of liquefaction.If but temperature is higher than 60 ℃, just this liquefaction crystal molecule can wreck;
Because the special angle mode of hydrone, the body of the solute molecule that diluted can be included in its liquefaction crystal Here it is the general course of dissolution of understanding.Present new discovery is, when by some means or other solute molecule being separated with hydrone (as via repeatedly dilution and concussion), hydrone still can keep " shape " memory to solute molecule.When body cell touches such hydrone, can be used as genuine solute molecule to " shape " of this solute molecule memory and equally treat, this is that more than 200 year historical hahnemannian foundation stone arranged.
Magnetic water, small-micelle water, high energy water gaging and characteristics thereof: water is by hydrogen and two kinds of element be combined intos of oxygen, but is not present in nature with one hydrone, but is agglomerated into (the H of group of hydrone by many hydrones
2O) n is present in nature (being above-mentioned liquid crystals), and the group of hydrone may be chain, ring-type, bulk or botryoidalis, minimum five hydrones, at most tens, tens of to hundreds of.These groups are also unstable, often change, as are subjected to effects such as energy, sunlight, magnetic field, vibration, pressure, ray, can improve the energy grade of hydrone, big hydrone group is gathered again become small-micelle water.Wherein, water is the method for most economical, the most stable, that usefulness is the highest raising hydrone energy grade through magnetic field magnetisation.Experiment showed, that hydrone group is more little, volume is more little, and penetration and dissolving power are strong more, easy more discrepancy cell.On health, because magnetic water has good penetration and dissolubility, can improve the ability of transporting endotrophic composition and/or medicine of water in human body, and remove the ability of blockage, thereby reach the purpose of curing the disease and keeping healthy.
Relevant patent: CN1124988C activated medical water, Preparation Method And The Use, it is less to the invention discloses a kind of water clusters, the dissolving power of water, penetration, expansionary force, metabolism power, cleaning strength all is better than the activated medical water of medical distilled water, it is through IDM activated water system by medical distilled water, the TKY activated water is handled, form after ultrasonic atomizatio processing and the magnetization processing, diluent and drug solvent that this type of activated medical water can be used as injection use, also can be used as physiological regulation agent, aesthetic health care water and medical water for cleaning, more original like product has more biological activity, the aquatic reason that meets human body changes, and is a kind of medical water of novel concept.
Patent CN1124988C introduces distilled water with the idea of magnetic water, small-micelle water, high energy water gaging, and possesses the serial advantage described in the above-mentioned patent abstract.But the activated medical water that this patent is produced is applicable in hospital, beauty parlor and uses, and is not suitable in the medical industry of producing various liquid pharmaceutical formulations and uses.Its reason has two, at first, during the treatment technology IDM activated water system of complete activated medical water, the processing of TKY activated water, ultrasonic atomizatio processing and magnetization were handled among the patent CN1124988C, two core technologies (50%) such as IDM activated water system, the processing of TKY activated water were because the charged production that can not be directly used in the liquid medicine dosage form; In addition, in the production process of each liquid dosage form of medical industry, heating hydrotropy, the heat sterilization preparation technology that is absolutely necessary.Yet in this requisite temperature was higher than 60 ℃ technical process, the various characteristics of the activated medical water that the CN1124988C patent is produced and advantage were with all gone.
Summary of the invention
In order to address the above problem, for the liquid pharmaceutical formulation that the characteristic and the advantage of magnetic water, small-micelle water, high energy water gaging are introduced suitability for industrialized production, promote the dissolving power of liquid pharmaceutical formulation self and promote liquid pharmaceutical formulation for further at the intravital penetration of machine, expansionary force, thereby further improve the stability and the general curative effect of liquid pharmaceutical formulation, researcher of the present invention by comprise ultrasonication, far infrared add can, magnetization handles etc. three kinds medicinal liquid carried out the activation processing mode, and liquid pharmaceutical formulation preparation technology has been done following improvement:
The present invention is under the prerequisite that does not change various liquid pharmaceutical formulation technologies in early stage substantially, after the operation that liquid pharmaceutical formulation need heat all early stages has been finished, or before just the medicinal liquid branch installs in the commercially available packing container shortly, in fluid reservoir and/or in fluid reservoir and pipeline that fluid reservoir links to each other and/or in fluid reservoir and pipeline that racking machine links to each other and/or in the pipeline at racking machine, to medicinal liquid carry out ultrasonication, far infrared add can, activation processing such as magnetization processing.
Wherein:
Liquid pharmaceutical formulation: liquid pharmaceutical formulation of the present invention is meant present existing liquid pharmaceutical formulation, and following new liquid pharmaceutical formulation of deriving out on the basis of existing liquid pharmaceutical formulation.Including, but not limited to, oral liquid medicine preparation: comprise syrup, tincture, oral solution, oral suspensions, Orally taken emulsion; External use liquid pharmaceutical preparation: comprise lotion, flushing liquor, enema, liniment, varnish, liniment, gel; Eye use liquid pharmaceutical formulation: comprise eye drop, and collyrium, intraocular injection solution is with ointment, gel for eye: ear liquid pharmaceutical formulation: comprise ear drop, ear lotion, ear spray, ear ointment, ear ointment, ear gel; Nasal liquid medicine preparation: comprise nasal drop, nasal douche, nasal spray, nose ointment, nose ointment, gel for nose; Reach aerosol, spray, injection, freeze-dried powder, concentrated solution for injection.
Ultrasonication: be to adopt the ultrasonication technology under the prerequisite of not destroying effective ingredient in the solution, destroy original liquefaction crystal that macromolecular mass constituted that is wrapped in the water of effective ingredient outside, make it to become the liquefaction crystal of small-micelle water.
Far infrared add can: be to adopt far-infrared technique to produce to be described as the radiation best band of light (consistent) of life at 5～18 microns far infrared with 9.6 microns of body surface radiation wavelengths by medical circle, produce resonance with the hydrone in the solution, big hydrone group is further diminished.Simultaneously, the energy frequency spectrum of memory in liquid crystal state water has the raising body immunity, the health-care effect that enhances metabolism.
Magnetization is handled: by liquid perpendicular cuts magnetic line of force in magnetic field, further promote the energy grade of hydrone, make it form little and stable liquid crystal state small water molecule group, the dissolving power that further promotes liquid pharmaceutical formulation self further improves the general curative effect of liquid pharmaceutical formulation with stability, further promote liquid pharmaceutical formulation at the intravital penetration of machine, expansionary force.
In the said method,
Ultrasonication can be selected batch (-type), continous way more preferably, and supersonic frequency can be selected 15～50kHz, more preferably 20～25kHz; Ultrasound intensity can be selected 5～2000W.
The radiation best band can be informal in the producing method of 5～18 microns far infrared, can select for use far-infrared ceramic material to produce, and also can select for use the hot-wire coil field to produce, or be produced by special textile material, more preferably selects for use far-infrared ceramic material to produce.
The magnetic field that magnetic field can select for use permanent magnet to produce, the also magnetic field that must select for use electric magnet to produce;
In said method, ultrasonication, far infrared add can, three kinds of processing modes such as magnetization processing etc., can use separately respectively according to the difference of the effective ingredient of product, be used in combination in twos, more preferably three kinds unite use.
Comparable advantage
The further technical scheme that promotes of interior quality that makes liquid pharmaceutical formulation of the present invention, from ultrasonication, far infrared adds can, magnetization is handled three angles and is started with, in the hope of with economic way to greatest extent with magnetic water, small-micelle water, high energy water gaging advantage and characteristics are introduced in the liquid pharmaceutical formulation of suitability for industrialized production, can be under the prerequisite of the production cost that does not increase manufacturing enterprise basically, promote the interior quality of liquid pharmaceutical formulation, make the stability of product be able to further lifting, in addition, because product is at the intravital penetration of machine, the raising of expansionary force can also make the speed that takes effect of product, bioavailability, general curative effect is able to corresponding lifting.
The specific embodiment
When the effective ingredient in the liquid pharmaceutical formulation when being afraid of macromole such as destructive protein, polypeptide, can adopt far infrared add can, two kinds of technological means such as magnetization processing are used in combination, also can use respectively.
Effective ingredient in liquid pharmaceutical formulation is common western medicine composition, or during the middle micromolecule effective ingredient that extracts from plant amedica, can adopt ultrasonication, far infrared add can, three kinds of processing modes such as magnetization processing unite use, also can use respectively.
Wherein:
Ultrasonication: can select for use S-910BCA type continuous-flow and ultrasonic-wave cell breakage instrument to finish power: 1000W frequency: 20KHz, maximum 38 liters/minute of the flows of handling.
Far infrared adds energy: can finish in the liquid-transport pipe-line that far-infrared ceramic material is made, wherein, the tube for transfusion that far-infrared ceramic material is made can be selected chromium oxide, nickel oxide, aluminium oxide, silicon oxide, manganese oxide for use, or aluminium oxide, silicon oxide, titanium oxide, calcium oxide, magnesium oxide, ferrum oxide, calcium oxide, boron oxide, oxidation receive behind ball milling or nanoscale micronization, at warp with stick together, molding, fire and form.
Magnetization is handled: can finish under the magnetic environment that the even numbered blocks neodymium-iron-boron permanent magnet is placed nonferromugnetic material formation infusion pipeline both sides createed.Wherein, for further improving the magnetization effect, the relative distance of the corresponding two blocks of Magnet in infusion pipeline both sides near more more good (0.5～8mm), that the cross-sectional area of putting the infusion pipeline at Magnet place is compared with last lower pipeline is the smaller the better (0.05～0.8: 1), so that form the flow of liquid of the fly-cutting magnetic line of force under the high-intensity magnetic field.
Claims (8)
1, a kind of further preparation method that promotes of interior quality that makes liquid pharmaceutical formulation, it is characterized in that, comprise ultrasonication, far infrared add can, magnetization handles three kinds medicinal liquid carried out the activation processing mode, is used for magnetic water, small-micelle water, high energy water gaging characteristic and advantage are introduced the liquid pharmaceutical formulation of suitability for industrialized production.
2, liquid pharmaceutical formulation as claimed in claim 1 is characterized in that, the liquid pharmaceutical formulation of invention is meant present existing liquid pharmaceutical formulation, and following new liquid pharmaceutical formulation of deriving out on the basis of existing liquid pharmaceutical formulation.
3, as claim 1,2 described present existing liquid pharmaceutical formulations, it is characterized in that, present existing liquid pharmaceutical formulation including, but not limited to, oral liquid medicine preparation: comprise syrup, tincture, oral solution, oral suspensions, Orally taken emulsion; External use liquid pharmaceutical preparation: comprise lotion, flushing liquor, enema, liniment, varnish, liniment, gel; Eye use liquid pharmaceutical formulation: comprise eye drop, and collyrium, intraocular injection solution is with ointment, gel for eye: ear liquid pharmaceutical formulation: comprise ear drop, ear lotion, ear spray, ear ointment, ear ointment, ear gel; Nasal liquid medicine preparation: comprise nasal drop, nasal douche, nasal spray, nose ointment, nose ointment, gel for nose; Reach aerosol, spray, injection, freeze-dried powder, concentrated solution for injection.
4, a kind of further preparation method that promotes of interior quality that makes liquid pharmaceutical formulation as claimed in claim 1, it is characterized in that, medicinal liquid is carried out ultrasonication, far infrared adds can, the environment of activation processing such as magnetization processing is: under the prerequisite that does not change various liquid pharmaceutical formulation technologies in early stage substantially, after the operation that liquid pharmaceutical formulation need heat all early stages has been finished, or before just the medicinal liquid branch installs in the commercially available packing container shortly, in fluid reservoir, and/or in fluid reservoir and pipeline that fluid reservoir links to each other, and/or in fluid reservoir and pipeline that racking machine links to each other, and/or in the pipeline of racking machine, medicinal liquid is carried out ultrasonication, far infrared adds can, activation processing such as magnetization processing.
5, as claim 1,4 described ultrasonications, it is characterized in that ultrasonication can be selected batch (-type), continous way more preferably, supersonic frequency can be selected 15～50kHz, more preferably 20～25kHz.
6, adding as claim 1,4 described far infrareds can, it is characterized in that, the radiation best band is informal in the producing method of 5～18 microns far infrared, can select for use far-infrared ceramic material to produce, also can select for use the hot-wire coil field to produce, or, more preferably select for use far-infrared ceramic material to produce by special textile material generation.
7, handle as claim 1,4 described magnetization, it is characterized in that the magnetic field that the magnetic field that magnetization is handled can select for use permanent magnet to produce, the also magnetic field that must select for use electric magnet to produce; The magnetic field of more preferably selecting permanent magnet for use and being produced.
8, as claim 1,4,5,6,7 described a kind of further preparation methoies that promote of interior quality that make liquid pharmaceutical formulation, it is characterized in that ultrasonication, far infrared in said method add three kinds of processing modes such as can, magnetizing processing, can use separately respectively according to the difference of the effective ingredient of product, be used in combination in twos, more preferably three kinds unite use.
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| CN 200510080826 CN1891295A (en) | 2005-07-01 | 2005-07-01 | Method for preparing liquid medicine preparation for further promoting intrinsic quality |
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| CN 200510080826 CN1891295A (en) | 2005-07-01 | 2005-07-01 | Method for preparing liquid medicine preparation for further promoting intrinsic quality |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105457149A (en) * | 2015-10-17 | 2016-04-06 | 高潮 | 4D combined skin care method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105457149A (en) * | 2015-10-17 | 2016-04-06 | 高潮 | 4D combined skin care method |
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