CN1872071B - Medication for enhancing body immunity, and fighting against senium, and preparation method - Google Patents
Medication for enhancing body immunity, and fighting against senium, and preparation method Download PDFInfo
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- CN1872071B CN1872071B CN2005100136356A CN200510013635A CN1872071B CN 1872071 B CN1872071 B CN 1872071B CN 2005100136356 A CN2005100136356 A CN 2005100136356A CN 200510013635 A CN200510013635 A CN 200510013635A CN 1872071 B CN1872071 B CN 1872071B
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- lycopene
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- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
A medicine for improving immunity and delaying sanility is disclosed. Its advantages are high natural level and safety and low toxic by-effect.
Description
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is the enhancing human body immunity power made of raw material and antidotal medicine and preparation method thereof.
Background technology
Lycopene (Lycopene), molecular formula C
40H
56Molecular weight 536.85, be a kind of of carotenoid, in all carotenoid, it has the function of the strongest elimination singlet oxygen and eliminates the function of free radical, and its elimination function to singlet oxygen is 2 times of carotene, 100 times of vitamin E: it can slow down the oxidation of low density lipoprotein, LDL, reduce the cholesterol in the blood plasma, anti-angiocardiopathy; Its effectively anticancer breeding has the anti-cancer and cancer-preventing effect, and has the activating immune cell function, but enhancing human body immunity power and defying age.Lycopene is a kind of understable material under normal conditions, and this is because have unique two bond distance's chains in its molecular structure, very easily oxidized degraded and isomerization in air, thus its function is reduced or inefficacy.Lycopene is a liposoluble substance, and lycopene commonly used is the oleoresin oily liquids of 5-10%, in general preparation, be difficult to dissolving and disperse, thus will be difficult to utilizations that be absorbed by the body when giving general formulation, so and limited its use.This just need be prepared into stable formulation with lycopene, just helps preventing the oxidative degradation of lycopene and isomerization and is convenient to take.At present, yet there are no the report that lycopene is prepared into stable formulation, have only application number to be: 0010915.7, publication number is: 1327749, name is called: the Chinese invention patent application of " lycopene oil ", it discloses a kind of oil product of lycopene, mainly be that lycopene is dissolved in the edible oil, though this is preparation lycopene goods, utilizes a kind of feasible method of lycopene that this method also still exists the easy oxidation of lycopene, character instability, takes inconvenient deficiency; Application number 03154152.6, the bibliographical information that publication number CN1485028A, name are called Lycopene drop pill with lycopene be that polyethylene glycol 6000, Macrogol 4000, stearic acid, gelatin, water and glycerol etc. are made drop pill in right amount.
Dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The purpose of this invention is to provide a kind of enhancing human body immunity power and antidotal medicine.
Another object of the present invention provides the preparation method of a kind of enhancing human body immunity power and antiaging agent.
The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is low, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
The consumption of drug component of the present invention and the selection of adjuvant thereof also grope to sum up to draw through the inventor in a large number, medicine of the present invention comprises: lycopene, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, described filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Described plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
In the adjuvant of further preferred drug component of the present invention, described filler adjuvant is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Described plasticity substrate is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose;
Further in the adjuvant of preferred drug component of the present invention, described filler adjuvant is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Described plasticity substrate is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum;
Best substrate adjuvant of the present invention is xylitol and starch, and xylitol is 1:0.2～1:0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1:0.2～1:0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1:0.2～1:0.4.
Adjuvant is 1:0.1～1:1 with the ratio of the weight of lycopene in the pharmaceutical composition of the present invention;
Adjuvant is 1:0.1～1:0.6 with the ratio of the weight of lycopene in the preferred pharmaceutical composition of the present invention;
Adjuvant is 1:0.2～1:0.4 with the ratio of the weight of lycopene in the best pharmaceutical composition of the present invention.
Medicine mesostroma adjuvant of the present invention and amount of drug are than being the scope that allows on the galenic pharmacy, and medicine described here can be that crude drug also can be the effective ingredient extract.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method; make common any preparation at present; but, preferably adopt following method to be prepared into dropping pill formulation, but this can not limit protection scope of the present invention in order to make each crude drug of this medicine bring into play drug effect better.
The preparation method of medicine of the present invention is as follows:
(a) get lycopene, adjuvant is standby;
(b) in appropriate amount of auxiliary materials, add lycopene, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Further preferred manufacturing procedure is:
The mixture heated melt temperature is 60～85 ℃ in the step (b), and mixing time is 10～30 minutes, and dripping a system temperature and be 60～85 ℃, dropper bore is 1.1～3.5 millimeters, and condensing agent is 0～18 ℃ liquid paraffin or a methyl-silicone oil.
Best preparation method is:
The mixture heated melt temperature is 64 ℃ in the step (b), and dripping a system temperature and be 64 ℃, dropper bore is 1.2～2.5 millimeters, and condensing agent is 0 ℃ a methyl-silicone oil.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 times, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, for example: selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis substrate adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of drop pill taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, makes drug effect faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill that this adjuvant is made can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
The present invention is under instruction of Chinese Medicine theory, preparation technology's test that process is a large amount of and pharmacology, the resulting preparation of pharmacodynamics test.
To those skilled in the art, technology contents disclosed according to the present invention, those skilled in the art will very clear other embodiment of the present invention, and the embodiment of the invention is only as example.Under the situation of not violating purport of the present invention and scope, can carry out various changes and improvements to the present invention.For example, use different crude drug or extract or active constituents of medicine or effective ingredient and adjuvant provided by the present invention to make various different preparations, particularly drop pill, but as long as use adjuvant of the present invention, all within protection domain of the present invention.
In order to understand the present invention better, the drop pill made from the new substrate of the present invention (according to embodiment 1 method preparation, hereinafter to be referred as the neolycopene drop pill) below; With the drop pill of making for the main matrix adjuvant with the Polyethylene Glycol (according to application number be: 03154152.6 document embodiment 1 method preparation, hereinafter to be referred as old Lycopene drop pill), by the test explanation advantages of the present invention such as the sticking ball of dissolve scattered time limit, drop pill soft durometer, drop pill of the two.
Test example 1: dissolve scattered time limit, weight differential contrast experiment's example
In vitro tests
Neolycopene drop pill and old Lycopene drop pill compare, and by measuring dissolve scattered time limit, investigate its good releasing effect; By measuring indexs such as the ball method of double differences is different, whether ripe, whether be fit to suitability for industrialized production if investigating its preparation technology.
1. test medication: neolycopene drop pill, old Lycopene drop pill.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
Three batches in table 1 with neolycopene drop pill and old Lycopene drop pill dissolve scattered time limit, weight differential relatively
Above-mentioned experimental data shows that the older Lycopene drop pill of the dissolve scattered time limit of neolycopene drop pill is few, and the ball method of double differences of neolycopene drop pill, old Lycopene drop pill is different to be controlled in the pharmacopeia prescribed limit.The result of the test explanation, the Lycopene drop pill that the new medium adjuvant is made is more conducive to medicine and plays a role in the shortest time, neolycopene drop pill, different all being controlled in the pharmacopeia prescribed limit of the old Lycopene drop pill ball method of double differences, but suitability for industrialized production.
Test example 2: the comparative observation of neolycopene drop pill and old Lycopene drop pill soft durometer, the sticking ball of drop pill
Compare by neolycopene drop pill and old Lycopene drop pill, measure indexs such as above-mentioned, investigate its effect.
1. test medication: neolycopene drop pill; Old Lycopene drop pill.
2. method and result:
Get each three batches of neolycopene drop pill and old Lycopene drop pills, be loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches of old Lycopene drop pill reserved sample observings of table 2.1 relatively
Table 2.2: three batches of neolycopene drop pill and old Lycopene drop pill character observation are relatively
Table 2.1,2.2 test data show that neolycopene drop pill soft durometer changes similar to old Lycopene drop pill, strong slightly; The neolycopene drop pill glues the ball variation, firmness change is similar to old Lycopene drop pill.The result of the test explanation, the sticking ball of new, old Lycopene drop pill changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1
(a) get lycopene 5.8g, xylitol 19.6g, starch 6.7g is standby;
(b) get xylitol and starch mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 2
(a) get lycopene 2.0g, lactose 17.8g, starch 4.2g is standby;
(b) get lactose and starch mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 3
(a) get lycopene 4.0g, xylitol 25.9g, arabic gum 7.1g is standby;
(b) get xylitol and arabic gum mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 4
(a) get lycopene 1.5g, xylitol 28.0g, xanthan gum 2.0g is standby;
(b) get xylitol and xanthan gum mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 45～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～70 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in-10～10 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 5
(a) get lycopene 2.5g, xylitol 16.5g, starch 7.0g is standby;
(b) get xylitol and starch mix homogeneously, add above-mentioned lycopene, mixture stirs at 45～115 ℃ of heating and meltings, and mixing time is 1～30 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splashes in-20～25 ℃ the vegetable oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 6
(a) get lycopene 1.5g, erythritol 29.5g is standby;
(b) get erythritol and add above-mentioned lycopene, mixture is at 55～75 ℃ of heating and meltings, stir, mixing time is 5～12 minutes, and insulation is 1.20～3.0 millimeters at 55～75 ℃ of temperature following system, dropper bore, splash in 0～15 ℃ the liquid paraffin, make 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly
Embodiment 7
(a) get lycopene 3.0g, xylitol 24.0g, Lac 6.0g is standby;
(b) get xylitol and Lac mixing mixing, add above-mentioned lycopene, mixture stirs at 45～115 ℃ of heating and meltings, mixing time is 5～20 minutes, and insulation is dripped system 58～70 ℃ of insulations, splash in 12 ℃ of liquid paraffin, make 1000 drop pill of drop pill, promptly.
Embodiment 8
(a) get lycopene 4.0g, xylitol 19.9g, starch 4.1g is standby;
(b) get xylitol and starch mix homogeneously, add above-mentioned lycopene, mixture stirs at 60～75 ℃ of heating and meltings, and mixing time is 10～60 minutes, insulation, at 55～65 ℃ of temperature following system, dropper bore is 1.0～3.5 millimeters, splashes in-20～25 ℃ the vegetable oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 9
(a) get lycopene 6.5g, lactose 16.6g, starch 3.4g is standby;
(b) get mixing of lactose and starch, add above-mentioned lycopene, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 10
(a) get lycopene 7.0g, xylitol 16.5g, arabic gum 15.5g is standby;
(b) get the mixing mixing of xylitol and arabic gum, add above-mentioned lycopene, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 11
(a) get lycopene 9.5g, xylitol 18.0g, trehalose 2.0g is standby;
(b) get xylitol and trehalose mixing mixing, add above-mentioned lycopene, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.21～3.5 millimeters, splashes in 0～15 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 12
(a) get lycopene 8.0g, xylitol 26.6g, tragakanta 3.4g is standby;
(b) get xylitol and tragakanta mix homogeneously, add above-mentioned lycopene, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～20 minutes, insulation, at 60～75 ℃ of temperature following system, dropper bore is 1.5～3.5 millimeters, splashes in 10～18 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 13
(a) get lycopene 7.5g, lactose 24.0g, xanthan gum 6.0g is standby;
(b) get lactose and xanthan gum mix homogeneously, add above-mentioned lycopene, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 62～67 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 4 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 14
(a) get lycopene 15.5g, xylitol 18.5g, arabic gum 3.5g is standby;
(b) get xylitol and arabic gum mix homogeneously, add above-mentioned lycopene, mixture stirs at 55～85 ℃ of heating and meltings, and mixing time is 5～30 minutes, insulation, at 58～68 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 15
(a) get lycopene 6.0g, lactose 37.0g, tragakanta 9.0g is standby;
(b) getting lactose and tragakanta mixes, add above-mentioned lycopene, fully mix, mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, and insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splash in 0 ℃ the methyl-silicone oil, make 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 16
(a) get lycopene 7.0g, xylitol 26.0g, Furcellaran 4.0g is standby;
(b) get xylitol and Furcellaran mixing, adding above-mentioned lycopene fully mixes, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 17
(a) get lycopene 15g, sorbitol 25g, tragakanta 11.5g is standby;
(b) get sorbitol and tragakanta mixing, add above-mentioned lycopene and fully mix, make 100 by method for preparing tablet thereof, promptly.
Embodiment 18
(a) get lycopene 10.5g, xylitol 14.5g, xanthan gum 8.0g is standby;
(b) get xylitol and xanthan gum mixing, adding above-mentioned lycopene fully mixes, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 15～25 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in 0～15 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 19
(a) get lycopene 30g, xylitol 183.3g, starch 16.7g is standby;
(b) get xylitol and starch mix homogeneously, add above-mentioned lycopene and fully mix, make 10000 capsules, promptly.
Embodiment 20
(a) get lycopene 0.5g, xylitol 13.3g, starch 6.7g is standby;
(b) get xylitol and starch mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 75 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 75 ℃ of temperature following system, dropper bore is 1.25～2.5 millimeters, splashes in 5 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 21
(a) get lycopene 0.5g, xylitol 15g, arabic gum 5g is standby;
(b) get xylitol and arabic gum mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 22
(a) get lycopene 0.5g, lactose 17g, starch 3g is standby;
(b) get lactose and starch mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 80 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.25～2.5 millimeters, splashes in 5 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 23
(a) get lycopene 2.5g, xylitol 25g, arabic gum 5g is standby;
(b) get xylitol and arabic gum mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 70 ℃ of heating and meltings, and mixing time is 20 minutes, insulation, at 70 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 10 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 24
(a) get lycopene 5.5g, lactose 22.5g, starch 3.5g is standby;
(b) get lactose and starch mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 80 ℃ of heating and meltings, and mixing time is 15 minutes, insulation, at 80 ℃ of temperature following system, dropper bore is 1.25～2.5 millimeters, splashes in 5 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 25
(a) get lycopene 8.5g, xylitol 18g, arabic gum 12.5g is standby;
(b) get xylitol and arabic gum mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 85 ℃ of heating and meltings, and mixing time is 25 minutes, insulation, at 80 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 8 ℃ the vegetable oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Claims (5)
1. enhancing human body immunity power and antidotal medicine is characterized in that this medicine consists of: lycopene 5.8g, xylitol 19.6g, starch 6.7g.
2. medicine as claimed in claim 1 is characterized in that adopting following method preparation:
(a) get lycopene 5.8g, xylitol 19.6g, starch 6.7g is standby;
(b) get xylitol and starch mix homogeneously, adding above-mentioned lycopene fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
3. the preparation method of the described medicine of claim 1 is characterized in that this method comprises the steps:
(a) get lycopene, adjuvant is standby;
(b) in appropriate amount of auxiliary materials, add lycopene, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
4. the preparation method of medicine as claimed in claim 3, it is characterized in that the mixture heated melt temperature is 60～85 ℃, mixing time is 10～30 minutes, and dripping a system temperature and be 60～85 ℃, dropper bore is 1.1～3.5 millimeters, and condensing agent is 0～18 ℃ liquid paraffin or a methyl-silicone oil.
5. the preparation method of medicine as claimed in claim 4 is characterized in that the mixture heated melt temperature is 64 ℃, and dripping a system temperature and be 64 ℃, dropper bore is 1.2～2.5 millimeters, and condensing agent is 0 ℃ a methyl-silicone oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100136356A CN1872071B (en) | 2005-06-01 | 2005-06-01 | Medication for enhancing body immunity, and fighting against senium, and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100136356A CN1872071B (en) | 2005-06-01 | 2005-06-01 | Medication for enhancing body immunity, and fighting against senium, and preparation method |
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| Publication Number | Publication Date |
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| CN1872071A CN1872071A (en) | 2006-12-06 |
| CN1872071B true CN1872071B (en) | 2010-11-10 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102894357A (en) * | 2012-08-16 | 2013-01-30 | 苏州谷力生物科技有限公司 | Health-care product with anti-aging and immunity-improving functions |
| CN104800181A (en) * | 2014-01-28 | 2015-07-29 | 南京生矶坊生物工程有限公司 | Lycopene tablet for enhancing functions of prostate, and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1485028A (en) * | 2003-08-13 | 2004-03-31 | 广西北生集团科技开发有限公司 | Lycopene drop pill |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1485028A (en) * | 2003-08-13 | 2004-03-31 | 广西北生集团科技开发有限公司 | Lycopene drop pill |
Non-Patent Citations (2)
| Title |
|---|
| 王巍.新基质复方丹参滴丸的研究.中国优秀博硕士学位论文全文数据库（硕士）医药卫生科技辑 2005年第1期.2005,(20051),第11页结论，第12页第1-2行. |
| 王巍.新基质复方丹参滴丸的研究.中国优秀博硕士学位论文全文数据库(硕士)医药卫生科技辑 2005年第1期.2005,(20051),第11页结论,第12页第1-2行. * |
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