CN1485028A - Lycopene drop pill - Google Patents
Lycopene drop pill Download PDFInfo
- Publication number
- CN1485028A CN1485028A CNA031541526A CN03154152A CN1485028A CN 1485028 A CN1485028 A CN 1485028A CN A031541526 A CNA031541526 A CN A031541526A CN 03154152 A CN03154152 A CN 03154152A CN 1485028 A CN1485028 A CN 1485028A
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- CN
- China
- Prior art keywords
- lycopene
- weight portion
- drop pill
- macrogol
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A lycopersicin drop pill. The molecule of lycopersicin has a peculiar long chain with double bonds, which is unstable in normal state and is easy to be oxidized, decomposed and isomerizated. lycopersicin also is fat-soluble, and is difficult to dissolve in common formulations. The invention provides lycopersicin drop pills with a water-soluble matrix, the effective components would be oxidized and isomerizated. The formulation is more stable, the effective components are easy for absorbing, which increases the bioavailability.
Description
Technical field
What the present invention relates to is a kind of stable and lycopene formulations of being easy to take, especially a kind of Lycopene drop pill.
Background technology
Lycopene (Lycopene), molecular formula C
40H
56, molecular weight 536.85 is a kind of of carotenoid, and in all carotenoid, it has the function of the strongest elimination singlet oxygen and eliminates the function of free radical, and its elimination function to singlet oxygen is 2 times of carotene, 100 times of vitamin E; It can slow down the oxidation of low density lipoprotein, LDL, reduces the cholesterol in the blood plasma, anti-angiocardiopathy; Its effectively anticancer breeding has the anti-cancer and cancer-preventing effect, and has the activating immune cell function, but enhancing human body immunity power and defying age.Lycopene has effect so widely, in human body health protection field unrivaled superiority like this is arranged, ought to be utilized widely, yet it but is a kind of understable material under normal conditions, this is because have unique two bond distance's chains in its molecular structure, very easily oxidized degraded and isomerization in air, thus its function is reduced or inefficacy.Lycopene is a liposoluble substance, and lycopene commonly used is the oleoresin oily liquids of 5-10%, in general preparation, be difficult to dissolving and disperse, thus will be difficult to utilizations that be absorbed by the body when giving general formulation, so and limited its use.This just need be prepared into stable formulation with lycopene, just helps preventing the oxidative degradation of lycopene and isomerization and is convenient to take.At present, yet there are no the report that lycopene is prepared into stable formulation, have only application number to be: 0010915.7, publication number is: 1327749, name is called: the Chinese invention patent application of " lycopene oil ", it discloses a kind of oil product of lycopene, mainly be that lycopene is dissolved in the edible oil, though this is preparation lycopene goods, utilize a kind of feasible method of lycopene, but this method also still exists the easy oxidation of lycopene, the character instability, take inconvenient deficiency, simultaneously, how lycopene is prepared into the dosage form that is easy to take, improve human body absorbing to lycopene, improving the bioavailability of lycopene in human body, is highly significant to this further investigation.
Summary of the invention
Purpose of the present invention prepares a kind of Lycopene drop pill of stable in properties exactly, to overcome the existing in use deficiency of existing lycopene, makes lycopene be easier to be absorbed by the body, and character is more stable, be easier to preserve, be utilized more widely.
For achieving the above object, the present invention has taked following measure: a kind of Lycopene drop pill, be prepared from by following method: get a weight portion lycopene add heating and melting 3.5-17 weight portion substrate in, fusion, mix homogeneously splashes in the coolant with the drop pill device, takes out, remove coolant, dry getting final product.Described lycopene refers to the lycopene oleo-resinous that content is 5-10%, described substrate refers to polyethylene glycol 6000, Macrogol 4000 and stearic acid, when Macrogol 4000 is 1 weight portion, polyethylene glycol 6000 is the 1-9 weight portion, stearic acid is the 0.3-1.5 weight portion, and described coolant refers to vegetable oil, liquid paraffin, dimethicone or their any mixture.
Take the present invention of above-mentioned measure, utilize water-soluble base that lycopene has been made the drop pill of oral solid dispersion, active ingredient is dispersed in the substrate, is difficult for directly contacting with air, be difficult for generation oxidation reaction or isomerization, thereby character is more stable.The present invention is through picking up survey, and be 15 minutes disintegration only, illustrates that the present invention very easily disperses, and active ingredient is easy to stripping and is absorbed, and helps improving its bioavailability.Pick up survey through multiple batches of, the content of active ingredient of the present invention all remains on more than 95% of labelled amount, illustrates that effective component content of the present invention is easy to control, steady quality.
Embodiment
Examples of implementation 1
Prescription: 5% lycopene oleo-resinous, 100 gram Macrogol 4000s, 150 grams
Polyethylene glycol 6000 150 gram stearic acid 50 grams
Preparation method:
(1) with above-mentioned Macrogol 4000 and polyethylene glycol 6000 mix homogeneously, be heated to 85 ℃ of fusions, add stearic acid, lycopene oleo-resinous fusion successively, put in the high-speed emulsifying machine mixing then 30 minutes;
(2) with the drop pill device with above-mentioned fusion mixing material splash in the coolant vegetable oil and cool off, take out, remove coolant, promptly obtain the present invention after the drying.
Detect through the dissolution in vitro test, content of lycopene of the present invention reaches 98% of labelled amount.
After testing, the present invention contains lycopene 1.1%.
Embodiment 2
Prescription: 10 lycopene oleo-resinouss, 100 gram Macrogol 4000s, 150 grams
Polyethylene glycol 6000 150 gram stearic acid 50 grams
Preparation method:
(1) with embodiment 1 preparation method (1);
(2) with the drop pill device with above-mentioned fusion liquid splash in the liquid Paraffin or dimethicone or both any mixture in, cooling is taken out, and removes coolant, obtains the present invention after the drying.
Detect through the dissolution in vitro test, content of lycopene of the present invention reaches 98% of labelled amount.
After testing, the present invention contains lycopene 2.2%.
Embodiment 3
Prescription: 8% lycopene oleo-resinous, 100 gram Macrogol 4000s, 50 grams
Polyethylene glycol 6000 250 gram stearic acid 50 grams
Preparation method:
It is identical with embodiment 1 or embodiment 2 preparation methoies,
Detect through the dissolution in vitro test, content of lycopene of the present invention reaches 98% of labelled amount.
After testing, the present invention contains lycopene 1.78%.
Embodiment 4
Prescription: 10% lycopene oleo-resinous, 100 gram Macrogol 4000s, 100 grams
Polyethylene glycol 6000 1000 gram stearic acid 150 grams
Preparation method:
(1) with embodiment 1 preparation method (1);
(2) with embodiment 1 or 2 preparation methoies (2);
Detect through the dissolution in vitro test, content of lycopene of the present invention reaches 98% of labelled amount.
After testing, the present invention contains lycopene and is about 0.8%.
Embodiment 5
Prescription: 10% lycopene oleo-resinous, 100 gram Macrogol 4000s, 100 grams
Polyethylene glycol 6000 150 gram stearic acid 50 grams
Vitamin E 50 grams
Preparation method:
(1) with above-mentioned Macrogol 4000 and polyethylene glycol 6000 mix homogeneously, be heated to 85 ℃ of fusions, add stearic acid, lycopene oleo-resinous and vitamin E fusion successively, put in the high-speed emulsifying machine mixing then 30 minutes;
(2) press preparation method (2) preparation of embodiment 1 or embodiment 2;
Detect through the dissolution in vitro test, content of lycopene of the present invention reaches 98% of labelled amount.
After testing, the present invention contains lycopene 2.3-2.5%.
Embodiment 6
Prescription: 10% lycopene oleo-resinous, 100 gram Macrogol 4000s, 100 grams
Polyethylene glycol 6000 10 gram stearic acid 50 grams
Vitamin E 100 grams
Preparation method:
Identical with embodiment 5 preparation methoies.
Detect through the dissolution in vitro test, content of lycopene of the present invention reaches 98% of labelled amount.
After testing, the present invention contains lycopene 2.0%.
Embodiment 7
Prescription: 10% lycopene oleo-resinous, 100 gram gelatin, 200 grams
Glycerol 10 gram water 200-400 grams
Preparation method:
(1) with above-mentioned gelatin, G ﹠ W mix homogeneously, be heated to 85 ℃ of fusions, add the lycopene oleo-resinous fusion, put in the high-speed emulsifying machine mixing then 30 minutes;
(2) with the drop pill device with above-mentioned fusion mixing material splash in the coolant vegetable oil and cool off, take out, remove coolant, promptly obtain the present invention after the drying.
Detect through the dissolution in vitro test, content of lycopene of the present invention reaches 98% of labelled amount.
After testing, the present invention contains lycopene 1.6%.
Claims (1)
1, Lycopene drop pill is characterized in that described drop pill is prepared from by following method: get a weight portion lycopene add heating and melting 3.5-17 weight portion substrate in, fusion, mix homogeneously splashes in the coolant with the drop pill device, takes out, remove coolant, dry getting final product; Described lycopene refers to the lycopene oleo-resinous that content is 5-10%, described substrate refers to polyethylene glycol 6000, Macrogol 4000, stearic acid, gelatin, water and glycerol, when Macrogol 4000 is 1 weight portion, polyethylene glycol 6000 is the 1-9 weight portion, and stearic acid is the 0.3-1.5 weight portion; When glycerol is 1 weight portion, water is that 2-4 weight portion, glycerol are that 0.2-0.5 weight portion, Macrogol 4000 are 0, polyethylene glycol 6000 is 0, stearic acid is 0, and described coolant refers to 1 weight portion above vegetable oil, liquid paraffin, dimethicone or their any mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031541526A CN1485028A (en) | 2003-08-13 | 2003-08-13 | Lycopene drop pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031541526A CN1485028A (en) | 2003-08-13 | 2003-08-13 | Lycopene drop pill |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1485028A true CN1485028A (en) | 2004-03-31 |
Family
ID=34156793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031541526A Pending CN1485028A (en) | 2003-08-13 | 2003-08-13 | Lycopene drop pill |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1485028A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100364541C (en) * | 2005-09-13 | 2008-01-30 | 河北师范大学 | Lycopene liposome and its prepn process |
| CN1872071B (en) * | 2005-06-01 | 2010-11-10 | 天津天士力制药股份有限公司 | Medication for enhancing body immunity, and fighting against senium, and preparation method |
-
2003
- 2003-08-13 CN CNA031541526A patent/CN1485028A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872071B (en) * | 2005-06-01 | 2010-11-10 | 天津天士力制药股份有限公司 | Medication for enhancing body immunity, and fighting against senium, and preparation method |
| CN100364541C (en) * | 2005-09-13 | 2008-01-30 | 河北师范大学 | Lycopene liposome and its prepn process |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |