CN1869694B - Portable specimen analysing device and portable urine analysing device - Google Patents

Portable specimen analysing device and portable urine analysing device Download PDF

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Publication number
CN1869694B
CN1869694B CN2006100814857A CN200610081485A CN1869694B CN 1869694 B CN1869694 B CN 1869694B CN 2006100814857 A CN2006100814857 A CN 2006100814857A CN 200610081485 A CN200610081485 A CN 200610081485A CN 1869694 B CN1869694 B CN 1869694B
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urine
mentioned
test paper
sample
colour generation
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CN1869694A (en
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仁科驎太郎
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CHUANGYUAN ELECTRONICS Co Ltd JIANGMEN
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CHUANGYUAN ELECTRONICS Co Ltd JIANGMEN
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Abstract

The invention discloses a portable sample analyzing device and a portable urinalysis device. And the portable urinalysis device has a pair of conductive terminals, connected with a urine detector which has a function of ohmmeter of determining resistance between the two conductive terminals, where the bottom side of a detection window is equipped with light sensor opposite to incident light of a sample material so as to determine the tone of the sample material by sensing the reflection strength of reflected light; when placed on the sample material, the urine get onto the two conductive terminals, and when the resistance between them reaches a certain value, such as about 100 KOhm, the urine can be detected; as the urine is detected, a timer is started up, and it determines the tone of the sample material after 30 seconds and converts the tone into urine sugar value. And the invention makes it easy to seize the time of determination by urine composition test paper after ingestion.

Description

Portable specimen analyzing device and portable urinalysis device
Technical field
The present invention relates to portable specimen analyzing device, the portable specimen analyzing device that particularly relates to bar-shaped sample composition test paper with sample colour generation sample, and then, be particularly related to portable urinalysis device, especially have the portable urinalysis device of the bar-shaped urine component test paper of urine colour generation sample material about use.
Background technology
Contain composition as humans and animals body fluid such as analyzing blood, sweat, urine, perhaps contain the simple means that becomes to grade in upper and lower water course, plant chimney stalk, the soil, can use the colour generation test paper.So-called colour generation test paper is typically litmus paper as everyone knows.Can be from being installed in bar-shaped paper tip, containing the composition that colour generation tonal variation that sample is the color reagent sample material comes analytical specimen to contain.For example, the method as non-blood testing method understanding blood glucose value is to measure blood glucose value with urine component test paper.The urine component test paper of understanding blood glucose value is the tip at bar-shaped paper, adds the sample material material that contains reagent.Sample material is urine at a touch, presents different tones according to the amount that contains sugar (glucose) in the urine.For with the contrast of colour generation tone and urine sugar value, make the standard colors mileometer adjustment, according to the colour generation tone, be designated as-, ±, (+), ++, +++wait tone mark number.As ± time judge that urine sugar value is the 50mg decilitre.The method that this use urine component test paper is measured urine sugar value is easy, so the examinee also can oneself be used for holding the variation of urine sugar value.
Yet using urine component test paper to measure urine sugar value is to place urine at the position of the examination material sample that contains reagent, utilizes the colour generation of urine and reagent reacting.So As time goes on, its colour generation tone changes constantly.Therefore, be judging urine sugar value as identical conditions according to colour generation, can with begin to place urine after 30 seconds the colour generation tone and the hue table of sample material compare, and penetrate and be the standard determination time.So, judge that according to colour generation the urine sugar value needs are the time management of unit with the second.
So, when measuring at every turn, the examinee need prepare the urine cup class, wherein take an amount of urine; Urinate and finish the back and prepare stopwatch etc., start the watch when urine composition sample material being immersed in the urine of urine cup etc.; Above-mentioned example need confirm to observe after 30 seconds the colour generation tone.Or, can when urinating, directly urine be come on the urine component test paper for avoiding preparing the loaded down with trivial details of urine cup etc.But at this moment also need to hold urine and begin to stick in the 30 seconds time later when urinating the composition sample material.So start the watch when beginning to be stained with urine is confirmed to stop to urinate, and observes the colour generation tone, perhaps need to rely on other people timing and affirmation tone after 30 seconds.Like this, be difficult to observe urine component test paper and be stained with the standard time of observing the colour generation tone after the urine, can't make condition determination same when the time comes, urine sugar value relatively has problems.
And urine sugar value has the one side that relies on the back time of ingesting, and is same for making condition, as requires to measure the urine sugar value of ingesting in urinating in back 2 hours.But because the moisture intake when having dinner, weather, health or work comfort level etc., most of people's urination times are indefinite, may not observe 2 hours this time.Can't make condition determination same when the time comes, relatively the having problems of urine sugar value.
And then the relation of urine component test paper colour generation and urine sugar value has along with urine sugar value increases the saturated characteristic of its colour generation variation.As in the above-mentioned hue mark number ++ be 500mg/dl, +++be 2000mg/dl.Even urine sugar value there are differences between promptly from 500mg/dl to 2000mg/dl, naked eyes also are difficult to pick out tonal difference.Although high urine sugar value has very big glucose in urine value difference in the reality like this, traditional dependence naked eyes judgement tone can't be distinguished its difference.
Like this, sample being placed the colour generation test paper, from the method for the tonal variation analytical specimen composition of its colour generation, want to analyze correct, need be the assurance time of unit and the difference of appropriately distinguishing tonal variation with the second.Carry out time management and distinguish that with the naked eye tone has limitation by staff, so when utilizing the convenience of coloring test to carry out instant analysis, in fact distinguish it is quite rough at the sample scene of taking.
Summary of the invention
The objective of the invention is to: solve the problem of this conventional art, portable specimen analyzing device is provided, so that sample is held the time of judging the colour generation tone after beginning to place the colour generation test paper easily.
Another object of the present invention is for providing portable urinalysis device, makes urine be stained with to hold behind the urine component test paper time of judging the colour developing tone to become easy.
And then other purpose is ingested the back when measuring according to urine component test paper for providing, and holds the portable urinalysis device of time easily.On this basis, further providing can be after urine sticks on the urine component test paper, although judge the asynchronism(-nization) of colour developing tone, the portable urinalysis device that condition determination is equal to.Although and and then the asynchronism(-nization) that provides the back of ingesting to measure according to urine component test paper, the portable urinalysis device that condition determination is equal to.In addition, also provide the portable urinalysis device that to distinguish urine sugar value difference in the high urine sugar value.
The object of the invention also is: intend the influence of bias light in the control colour generation mensuration.And then the influence of urinating look in the control colour generation mensuration.And, portable urinalysis device and the different influence of the urine temperature difference during the control colour generation is measured.
Below the invention of Ji Zai application project can reach an above-mentioned purpose at least.
For achieving the above object, the present invention proposes a kind of portable specimen analyzing device: described device has the waterproof construction shell of the handle part that can singlehanded control, with be located on the above-mentioned shell, tip portion has the test paper fixed part of the bar-shaped colour generation test paper of fixed preparation colour generation sample material, with from above-mentioned shell projection, be located near the above-mentioned test paper fixed part and the pair of conductive terminal of mutually insulated, and the conductivity degree of measuring between above-mentioned pair of conductive terminal detects the sample detector of placing sample, with calculate the sample that above-mentioned sample detector detects the detection elapsed time behind the sample and detect through timer, reach the standard time process display part that measures the above-mentioned colour generation bioassay standard time with the expression above-mentioned detection elapsed time, above-mentioned sample detector and above-mentioned sample detect through timer and are arranged on above-mentioned waterproof construction enclosure.
The portable specimen analyzing device that the present invention relates to is: described device has the waterproof construction shell of the handle part that can singlehanded control, with on above-mentioned shell, be provided with, tip portion has the test paper fixed part of the bar-shaped colour generation test paper of fixed preparation colour generation sample material, detect window with the printing opacity that is provided with on the part of above-mentioned shell, with from above-mentioned shell projection, be located at and above-mentionedly detect window nearby and the pair of conductive terminal of mutually insulated, with detect the sensor part that window is measured said sample material colour generation by above-mentioned, and the conductivity degree of measuring between above-mentioned pair of conductive terminal detects the sample detector of placing sample, with calculate the sample that above-mentioned sample detector detects the detection elapsed time behind the sample and detect the elapsed time timer, detect the colour generation measured value of the said sample material of measuring in the elapsed time with the detection elapsed time with it according to aforementioned calculation, calculate and export the sample composition measuring and calculating portion of sample composition on the said sample material, the sensor, above-mentioned sample detector, above-mentioned sample detects the elapsed time and above-mentioned sample composition measuring and calculating portion is located at above-mentioned waterproof construction enclosure.
In the portable specimen analyzing device that the present invention relates to, described device has the sample that is located at sample setting side, expression sample laying state and detects announcer.
The portable specimen analyzing device that the present invention relates to is: described device has the waterproof construction shell of the handle part that can singlehanded control, with be located on the above-mentioned shell, tip portion has the fixedly test paper fixed part of the bar-shaped urine component test paper of urine colour generation sample material, with outstanding from above-mentioned shell, be located near the above-mentioned test paper fixed part and the pair of conductive terminal of mutually insulated, and the conductivity degree between the above-mentioned pair of conductive terminal of mensuration, detect the urine detector of placing urine, with calculate above-mentioned urine detector and detect and detect the urine examination in elapsed time after the urine and go out through timer, the standard time that reaches the bioassay standard time of measuring above-mentioned colour generation with the expression above-mentioned detection elapsed time is passed through display part, and above-mentioned urine detector and above-mentioned urine examination go out through timer to be located at above-mentioned waterproof construction enclosure.
The portable urinalysis device that the present invention relates to is: described device is the waterproof construction shell with handle part that one hand can control, with be located on the above-mentioned shell, tip portion has the test paper fixed part of the bar-shaped urine component test paper of fixing urine colour generation sample material, with be located on the above-mentioned shell, accumulate the spill urine of placing urine and accumulate portion, with outstanding from above-mentioned shell, be located near the above-mentioned test paper fixed part and the pair of conductive terminal of mutually insulated, and the conductivity degree of measuring between above-mentioned pair of conductive terminal detects the urine detector of placing urine, with calculate above-mentioned urine detector and detect the urine examination in the detection elapsed time after the urine and go out through timer, reach the standard time process display part that calculates the above-mentioned colour generation bioassay standard time with the expression above-mentioned detection elapsed time, above-mentioned urine detector and above-mentioned urine examination go out through timer to be located at above-mentioned waterproof construction enclosure.
The portable urinalysis device that the present invention relates to is: described device has the waterproof construction shell of the handle part that one hand can control, with be located on the above-mentioned shell, tip portion has the test paper fixed part of the bar-shaped urine component test paper of fixing urine colour generation sample material, with the window that detects that printing opacity is set on the part of above-mentioned shell, with outstanding from above-mentioned shell and be located at and above-mentionedly detect window nearby and the pair of conductive terminal of mutually insulated, with detect the detecting means that window is measured said sample material colour generation by above-mentioned, and the conductivity degree of measuring between above-mentioned pair of conductive terminal detects the urine detecting element of placing urine, with calculate above-mentioned urine detector and detect the urine examination in the detection elapsed time after the urine and go out through timer, with the detection elapsed time and the colour generation measured value that detects the said sample material of measuring in the elapsed time according to aforementioned calculation, calculate and export the urine composition measuring and calculating portion of the composition of urinating on the said sample material, above-mentioned detecting means, above-mentioned urine detector, above-mentioned urine examination goes out through timer and above-mentioned urine composition measuring and calculating portion to be located at above-mentioned waterproof construction enclosure.
The portable urinalysis device that the present invention relates to is: described device has the waterproof construction shell of the handle part that can singlehanded control, with be located on the above-mentioned shell, tip portion has the test paper fixed part of the bar-shaped urine component test paper of fixing urine colour generation sample material, with be located on the above-mentioned shell, accumulate the placement urine, the urine that is concavity accumulates portion, detect window with the printing opacity that on the part of above-mentioned shell, is provided with, with be arranged on the above-mentioned shell, urine is guided into the urine stream of urine examination exit window from the above-mentioned urine portion of accumulating, with the pair of conductive terminal that and mutually insulated outstanding from shell are set on the above-mentioned urine stream, with measure the detecting means of said sample material colour generation by detecting window, and the conductivity degree between the above-mentioned pair of conductive terminal of mensuration, detect the urine detector of placing urine, the urine examination that detects the urine back detection elapsed time with the above-mentioned urine detector of calculating goes out through timer, with the detection elapsed time and the colour generation measured value that detects the said sample material of measuring in the elapsed time according to said determination, calculate and export the urine composition measuring and calculating portion of the composition of urinating on the said sample material, above-mentioned urine detecting means, above-mentioned urine detector, above-mentioned urine examination goes out through timer and above-mentioned urine composition measuring and calculating portion to be located at above-mentioned waterproof construction enclosure.
In the portable urinalysis device that the present invention relates to, described device is to have the said sample material on the above-mentioned urine component test paper club shaped structure single face, above-mentioned test paper fixed part aligns the above-mentioned window that detects with the said sample material, above-mentioned urine component test paper is fixed on the urine stream, and then match with above-mentioned shell, be provided with and be fixed on the shadow shield that covers above-mentioned urine component test paper on the urine stream, form the urine outlet with above-mentioned shell and above-mentioned shadow shield.
In the portable urinalysis device that the present invention relates to, described device has the urine examination that is arranged on the laying state of placing urine side, expression urine and goes out announcer.
Described device be above-mentioned urine composition measuring and calculating portion according to the above-mentioned detection elapsed time arrive the fixed colour generation measured value of bioassay standard during the time, calculate and export above-mentioned urine composition.
Described device is that composition is urinated according to high concentration by above-mentioned urine composition measuring and calculating portion, the colour generation measured value of colour generation measured value before reaching capacity set as the standard measured value, in the detection elapsed time when arriving above-mentioned canonical measure value, calculate and export above-mentioned urine composition according to above-mentioned colour generation measured value.
Described device is an above-mentioned urine composition measuring and calculating portion, fall into a trap to count in the said determination standard time and state on the urine composition during defectiveness, according to the pick up counting plural colour generation measured value of the plural minute set in this scope till the said determination standard time of above-mentioned detection elapsed time, calculate said determination is urinated composition in the standard time presumed value.
Described device is that above-mentioned detecting means is from the timing of above-mentioned detection elapsed time, measure the colour generation of plural minute respectively, above-mentioned urine composition measuring and calculating portion calculates the most definite urine composition presumed value according to the plural colour generation measured value and the predetermined correction curve of said determination.
Described device is that above-mentioned plural minute begins with the timing of above-mentioned detection elapsed time is starting point, is the plural minute of fixing time the 2nd fixing time from the 1st.The 1st fix time and the 2nd fix time and place for continuing urine, the temperature difference of the temperature of urine and portable urinalysis unit temp diminishes, and sets in the stable scope of the color reaction of sample material.
Described device be above-mentioned shell comprise inside have the test paper storage chamber of placing above-mentioned urine component test paper outer cover body and can be from above-mentioned outer cover body dismounting, cover the lid of the above-mentioned urine component test paper gateway of above-mentioned test paper storage chamber.Said sample material fixed part has lid side fixed part that is located on the lid and the base side fixed part that is located on the above-mentioned outer cover body, relies on the body fixed part that covers the side fixed part and be located on the outer cover body to determine above-mentioned urine component test paper position.
The portable urinalysis device that the present invention relates to is: the lid disassembly process timer of lid disassembly process time and represent that the above-mentioned lid disassembly process time reaches predefined urine and places the schedule time of the schedule time through display part when described device has the lid dismounting detector that detects the lid dismounting and calculates from the dismounting lid.
To be above-mentioned urine composition measuring and calculating portion be different from the above-mentioned predetermined lid disassembly process time when placing urine to described device, according to the schedule time that configures in advance and relevant urine composition rectification data, revise above-mentioned urine detector and detect the poor of lid disassembly process time and the above-mentioned schedule time when placing urine, calculate the presumed value of urinating composition in the above-mentioned schedule time.
Described device is that above-mentioned detecting means comprises: not urinated look when placing urine on the said sample material in the scope of colour generation wave spectrum influences the light-emitting component and the photo-sensitive cell of radiation wavelength light and is located at above-mentioned photo-sensitive cell front, the optical filter by above-mentioned light-emitting component wavelength band territory, with sense light emitting-type sensor.
Described device is that the light-emitting component that is provided with on the above-mentioned shadow shield has in the scope of emission wavelength spectrum when placing urine on the said sample material, is not urinated the light-emitting component that look influences the radiation wavelength light.Above-mentioned detecting means uses the see through light of above-mentioned light-emitting component radiating light through the said sample material, detects the colour generation of said sample material.
Described device is the value that above-mentioned urine detector is exported above-mentioned conductivity degree when placing urine.
According to above-mentioned at least one structure, detect the urine that the colour generation test paper is placed from the variation of the conductivity degree between the pair of conductive terminal, start sample and detect through timer.So be easy to calculate the time that arrives the bioassay standard time, make and judge that the colour generation test paper places behind the sample time of colour generation tone and hold and become easy.
According to above-mentioned at least one structure, detect urine component test paper from the variation of the conductivity degree between the pair of conductive terminal and placed urine, start urine examination and go out through timer.So, be easy to calculate the time that arrives the bioassay standard time, make and judge that urine component test paper is stained with after the urine time of the tone of colour generation and holds and become easy.
According to above-mentioned at least one structure, detect the urine portion of accumulating from the variation of the conductivity degree between the pair of conductive terminal and accumulated urine, be stained with urine on the urine component test paper, start urine examination and go out through timer.So, be easy to calculate the time that arrives the bioassay standard time, make and judge that urine component test paper is stained with after the urine time of colour generation tone and holds and become easy.Simultaneously, supply with urine component test paper with enough urine from the urine portion of accumulating, the analysis of urine composition can be more definite.
And, according to above-mentioned at least one structure, as have the urine component test paper sample material in the face of to detecting window, even the urine component test paper face of placing urine and the face with sample material is under the situation for the opposite sides structure like this, also urine can be accumulated in urine and accumulate portion, the urine that accumulates is flowed to along the urine stream detect window direction, the i.e. direction of sample material.So the urine portion of accumulating can supply with the enough urines of sample material, the analysis of urine composition is more definite.
According to said structure at least one, match with shell, configuration covers the shadow shield of urine component test paper fixing on the urine stream.So, can control the influence of bias light in the colour generation mensuration.
The colour generation of the colour generation test paper of urine component test paper etc. is determined at enclosure to carry out, and is difficult to understand the laying state of sample and urine.According to above-mentioned at least one structure, the urine examination of placing a side allocation list indicating this or the urine laying state of sample or urine goes out display, so can be fast and understand the laying state of sample or urine easily.
According to above-mentioned at least one structure, detect urine component test paper from the variation of conductivity degree between the pair of conductive terminal and be stained with urine and start urine examination and go out through timer, measure the colour generation of sample material from detecting window, measure the urine composition.The mensuration of urine composition is carried out according to detecting the colour generation measured value of elapsed time arrival bioassay standard during the time.So, as long as urine component test paper is stained with urine, just measure the urine composition of bioassay standard in the time automatically, hold urine component test paper easily and be stained with the time of judging the colour generation tone after the urine.
According to above-mentioned at least one structure, under the high urine sugar value situation, be colour saturation before the time because of arriving bioassay standard, set the standard measured value of unsaturated colour generation, relatively arrive the detection elapsed time of this value.Can distinguish the difference of urine sugar value in the hyperglycaemia value according to this structure.
According to above-mentioned at least one structure, when being 30 seconds such as the bioassay standard time, when the accidental detection elapsed time, the colour generation determination data was short of in 30 seconds, perhaps observe when being exceptional value from other determination data, also can be according to the determination data of other plural minute, as every 5 seconds determination data interpolation, interpolation, extrapolation etc., remedy the determination data of bioassay standard time.So,, also can condition determination be equal to according to interpolation even urine component test paper is placed time and bioassay standard asynchronism(-nization) that the colour generation tone is judged in the urine back.
According to above-mentioned at least one structure,, carry out the most definite urine composition and infer with statistical treatment relatively more predetermined correction curve and determination data.So can more accurate or promptly measure the urine composition.
And, the temperature of portable urinalysis device and the temperature of urine not simultaneously, color reaction is affected.Therefore, utilize the urine temperature, continue to place urine more than the certain hour at certain and can reduce this temperature difference.According to above-mentioned at least one structure, continue to place urine, the temperature difference at temperature and the portable urinalysis unit temp of urine disappears, set in the range of stability of sample material color reaction the 1st fix time and the 2nd fix time, utilization plural minute therebetween carries out colour generation mensuration.Therefore, can control portable urinalysis device and the different influence of the urine temperature difference in the colour generation mensuration.
According to above-mentioned at least one structure, can dismounting lid and outer cover body, make test paper holder and urinalysis apparatus integration, improve portablely, and can utilize lid and outer cover body on shell, to determine the position of urine component test paper, and fix.
According to above-mentioned at least one structure, timing was represented from the elapsed time of lid dismounting, so the time utilization of back to urine component test paper mensuration that this time can be used to ingest.As uncap when having a meal, take out urine component test paper, close upper cover urine component test paper and shell are configured, calculate the elapsed time from this moment beginning, thus the schedule time, as after ingesting 2 hours, need only and on urine component test paper, be stained with urine, be easy to manage.So, hold from the back of ingesting and also become easy to the time that relies on urine component test paper to measure.
According to above-mentioned at least one structure, though from the back of ingesting to the asynchronism(-nization) that relies on urine component test paper to measure, also can condition determination be equal to, as elapsed time after ingesting being equal to and determining the urine composition according to correcting data.And according to above-mentioned at least one structure, the influence of tone beyond the reagent that can get rid of sample material and the urine reaction colour generation is as the influence of urine look etc.In addition, according to above-mentioned at least one structure, can also hold the difference of the compositions such as electrolyte that contain in the urine according to the conductivity degree.
Like this, rely on the portable specimen analyzing device that the present invention relates to, sample is placed hold behind the colour generation test paper time of judging the colour generation tone to become easy.According to the portable urinalysis device that the present invention relates to, the time management that urine component test paper is stained with carry out after the urine colour generation tone to be judged becomes easy.According to the portable urinalysis device that the present invention relates to, make and hold the back of ingesting and become easy to the time that the dependence urine component test paper is measured.
Use following drawing, describe the form of implementation that the present invention relates in detail.When following sample is urine, promptly describe with regard to portable urinalysis device.But used sample is not under the situation of urine, and corresponding sample adopts the colour generation test paper, sets the parameter that is fit to its colour generation test paper characteristic, the portable specimen analyzing device of bioassay standard time etc. also can be implemented the present invention as described later.
Description of drawings
Fig. 1 is the drawing synoptic diagram of the demonstration urine component test paper that uses of the present invention.
Fig. 2 is vertical view, front view (FV), ground plan, the outboard profile of the portable urinalysis device in the example that the present invention relates to.
Fig. 3 is the sectional view of the portable urinalysis device in the example that the present invention relates to.
Fig. 4 is the portable urinalysis device in the example that the present invention relates to, the vertical view that fixation clamp, outer cover body and lid are separated, front view (FV), ground plan.
Fig. 5 is the portable urinalysis device in the example that the present invention relates to, and the figure of fixation clamp function is described.
Fig. 6 is the portable urinalysis device in the example that the present invention relates to, and the figure of other functions of fixation clamp is described.
What Fig. 7 was that this figure shows is portable urinalysis device in the example that the present invention relates to appearance when removing lid.
Fig. 8 is the portable urinalysis device in the example that the present invention relates to, and shows the figure of urine component test paper position.
Fig. 9 is the figure that shows position relation between portable urinalysis device in the example that the present invention relates to and the urine component test paper.
Figure 10 is a part of amplification profile of the portable urinalysis device in the example that the present invention relates to.
Figure 11 is the integrated circuit plate figure of the portable urinalysis device in the example that the present invention relates to.
Figure 12 is the urinalysis process flow diagram in the example that the present invention relates to.
Figure 13 is the urinalysis process flow diagram in the example that the present invention relates to.
Figure 14 is the urinalysis process flow diagram in the example that the present invention relates to.
Figure 15 is to be parameter with the urine sugar value, shows reflection strength and detects the figure that the elapsed time concerns.
Figure 16 is an exemplary plot of being obtained the correction curve of urine sugar value by the time T b of reflection strength arrival canonical measure value B.
Figure 17 is and detects relevant line exemplary plot of elapsed time.
Figure 18 is the correction exemplary plot about the lid disassembly process time.
Figure 19 is the outer cover body vertical view of other examples.
Figure 20 is the outer cover body of other examples of explanation and the location diagram of urine component test paper.
Figure 21 is the sectional view of AA line among Figure 20.
Figure 22 is the sectional view of BB line among Figure 20.
Figure 23 is that the urine of the outer cover body of other examples accumulates portion and near the sectional view of urine stream.
Figure 24 is the key diagram that urine accumulates the structure function of portion, urine stream and pair of conductive terminal etc. that possesses of other examples.
Figure 25 is the vertical view of the portable urinalysis device under other further examples.
Figure 26 is the front view (FV) of the portable urinalysis device under other further examples.
Figure 27 is the ground plan of the portable urinalysis device under other further examples.
Figure 28 is under other further examples, and lid embeds the front view (FV) of outer cover body part.
Figure 29 is under other further examples, and lid embeds the ground plan of outer cover body part.
Figure 30 is under other further examples, and lid embeds the front view (FV) of outer cover body part.
Figure 31 is under other further examples, and shadow shield embeds the front view (FV) of outer cover body part.
Figure 32 is under other further examples, and shadow shield embeds the ground plan of outer cover body part.
Figure 33 is under other further examples, the expansion sectional view of outer cover body and shadow shield part.
Figure 34 shows the figure of urine color to the wave spectrum influence of colour generation.
Figure 35 is to be parameter with the glucose in urine degree, about reflection strength with detect the exemplary plot of the correction curve in elapsed time.
Figure 36 is the key diagram of the temperature difference of urine temperature and portable urinalysis device to the reflection strength influence.
Figure 37 is under other further examples, and the figure of the method that the temperature difference that suppresses between urine temperature and the portable urinalysis device exerts an influence to reflection strength is described.
Figure 38 is under other further examples, shows that LED380 is along with the figure that detects the lamp flicker situation of urinating the detection elapsed time after injecting and changing.
Figure 39 is under other further examples, the key diagram of other insertions of urine component test paper.
Figure 40 is under other further examples, and the sectional view of other insertions of urine component test paper is described.
[explanation of label symbol]
10,310 portable urinalysis devices, 12 urine component test papers, 14 sample materials, 16 shells, 17 fixation clamps, 18,218,318 outer cover bodies, 20,320 lids, 26,326 liquid crystal displays, 27,327 test paper storage chambers, 28 circuit storage chambers, 50,52,54,56 grooves, 58 end walls, 60 end portions, 62a, 62b, 62c, 256a, the 256b extension, 70 lid dismounting detectors, 72a, 72b, 272a, 272b, 372 electric conductivity terminals, 74,374 detect window, 76,376 sense light emitting-type sensors, 80 urine detectors, 90 integrated circuit, 92 control circuits, 94 input and output control parts, 110 urine examinations go out through timer, 112 lid disassembly process timers, the storage of 116 computational datas, 118 schedule times were corrected data storage, and 122 colour generation times were corrected data storage, 130 sense light emitting control portions, 132 colour generation determination parts, 134 urine composition measuring and calculating portions, 136 display control units, 250,350 urine accumulate portion, 252 urine streams, 254a, the 254b baffle plate, 300,302,304 urine, 317 shadow shields, 319 clips, 340 skew walls, 351 horn-like openings, 356 directed parallel, 357 bossings, 361 urine outlets, 380LED, 382 guiding grooves, 384 slide detains 386 battery installation section positions
Embodiment
As the colour generation test paper that is installed on the portable specimen analyzing device, can the PH test paper, sxemiquantitative ion test paper, to analyze with test paper, simple and easy examination of water test paper etc. be object.Comprise in the sxemiquantitative ion test paper: the nitrite ion that detects nitrous acid concentration in the food additives with test paper, detect nitric nitrogen concentration in the soil the nitrate ion test paper, detect concentration of metal ions in drinking-water and the industrial water drainage aluminium ion with test paper, copper ion with test paper, nickel ion with metallic ions such as test paper with test paper, detect the ascorbic acid ion test paper etc. that fruit juice etc. contains vitamin C concentration.Analyze with comprising in the test paper: the zinc of analyzing the zinc composition with test paper, analyze residual chlorine chlorine with test paper, analyze the tin composition tin with the sexavalent chrome of test paper, analysis sexavalent chrome composition with test paper etc.
Sample as being placed on the portable specimen analyzing device colour generation test paper can use liquid such as plant chimney stalk from cover to cover as sample.And, if when being object, can will check that adding Purified Water behind the antecedent soil moisture of object fully stirs with the composition in the soil, with suitable filter paper etc. with this soil constituent filtration, with it as sample.
Sample is placed on the colour generation test paper, as its name suggests, except with sample as injection is stained with on the colour generation test paper, also samples such as industrial water drainage can be taken in the container, the portable specimen analyzing device that the colour generation test paper is housed is immersed in the sample in its container.
[embodiment 1]
The portable urinalysis device that the present invention relates to is for using the device of urine component test paper analysis urine composition.Fig. 1 (a) is outboard profile for the figure of expression urine component test paper 12, (b) is planimetric map.As shown in Figure 1: urine component test paper 12 is bar-shaped test paper, and tip portion has and comprises that urine is the sample material 14 of color reagent.The reagent that sample material 14 contains is different and different according to the urine composition that will detect.As urobilinogen, ketoboidies, cholerythrin, nitrite, white blood cell etc. in the glucose (glucose in urine) of market sale, protein, occult blood, the urine for detect sample material or the test paper that object is made according to each difference.And 1 piece of test paper is provided with plural sample material, and the test paper that can corresponding plural number detects object also has sale.Below, the urine component test paper that just can detect urine sugar value describes, but also can be that other detects the urine component test paper that object is used.
Fig. 2 is the outside drawing of portable urinalysis device 10, (a) is top figure, (b) is front view (FV), (c) is ground plan, is outboard profile (d) and (e).Portable urinalysis device 10 is made of the shell 16 and the fixation clamp 17 of resin structure.The parts of fixation clamp 17 can be lived shell 16 embedding firmly, have clip 19.Fixation clamp 17 and shell 16 can be hung on the pocket with clip 19.Other function about fixation clamp 17 is treated aftermentioned.
But shell 16 is its sidewall dominated by hand etc., one hand fixation degree size.Shell 16 is by outer cover body 18 and can form from the lid 20 of shell 18 dismounting, the dismounting between lid 20 and the outer cover body 18 partly mutually tightly embedding, be waterproof construction, can not enter urine, water etc.The bottom surface of outer cover body 18 is provided with power switch 22, reads over urinalysis result's memory exhalation button 24 and liquid crystal display 26.Also can use as electronics demonstration means such as LED and replace liquid crystal display.
Fig. 3 is the sectional drawing of portable urinalysis device 10.As shown in Figure 3, waterproof construction shell 16 is divided into the upper and lower.Top is provided with the test paper storage chamber 27 of depositing standby urine component test paper, and the bottom is provided with electronic circuit portion that is made up of various electronic units such as circuit substrate, various sensor, special-purpose LSI etc. and the circuit installation room 28 of laying battery.The 26S Proteasome Structure and Function aftermentioned of electronic circuit portion.
Each disassembles the diagrammatic sketch of composition from state the fixation clamp 17 that Fig. 4 from mutual embedding for portable urinalysis device 10, outer cover body 18, lid 20, (a) is that top figure, (b) are ground plan for front view (FV), (c).And for ease of profile and the inner face of fixation clamp 17 and the relation of with the mutual embedding of lid inner face of understanding outer cover body 18, outer cover body 18 usefulness outside drawings, fixation clamp 17 and lid 20 are represented with sectional view respectively.As shown in the figure, the profile of outer cover body 18 by be positioned at whole central authorities, the rectangle part 34 of the other end of the tapering part 32 of the part 30 of handle part when being equivalent to outer cover body 18 dominated by hand and intimate rectangle and corresponding fixation clamp 17 1 ends and corresponding lid 20 forms.
Fixation clamp 17 has the profile space 36 that tapering part 32 is installed at outer cover body 18 1 ends, has wedge-like spring leaf 40 with tapering part 32 relative parts.When wedge-like spring leaf 40 is installed urine component test paper 12 in aftermentioned, have the function of urine component test paper 12 from groove 56 guiding extensions 62.And 36 bottom is provided with sheet metal 42 in the space, relies on this sheet metal, and fixation clamp 17 can be the end with the face 43 with sheet metal 42, and space 36 is fixed on the surface of contact upward.Its shape as shown in Figure 5.Therefore, fixation clamp 17 also is to have that embedding, the parts of fixed housing function.And the clip 19 of use fixation clamp 17 also can be with the posture traverse of portable urinalysis device to be easy to observe.Its pattern such as Fig. 6.
Return Fig. 4, lid 20 has the profile space 44 of placing rectangle 34 on outer cover body 18 other ends, with the groove 52 of outer cover body middle body over against part configuration wrist 46, wrist 46 is provided with and slightly is hemispheric control part 48.
Outer cover body 18 has groove 50,52,54,56 in the part 30 and the central authorities above the tapering part 32 that are close to rectangle along the outer cover body length direction.These grooves make urine component test paper corresponding with the part that is installed in shell 16.
Groove 50 is arranged on the most close lid side, and the width of groove and the width of urine component test paper are almost equal, and the size of groove depth is set to such an extent that approximately equate with the thickness of urine component test paper, and its groove end is an end wall 58.This end wall 58 is over against the end portion 60 of the groove 56 of the most close fixation clamp side setting.Be end wall 58 over against the length setting of end portion 60 be the length of urine component test paper, with the length direction of end wall 58 and end portion 60 decision urine component test papers.
Groove 52 is adjacent with groove 50, easily and urine component test paper supporting, fabric width is wide slightly, length direction is also enough wide.Groove 54 is adjacent with groove 52, and the width of groove width and urine component test paper is almost equal.The groove depth of groove 52 and groove 54 is set thickly slightly than the thickness of urine component test paper.
Groove 56 is the wide slightly groove that is provided with at tapering part 32, determines the position of urine component test paper sample material, is equivalent to place the part of urine.The degree of depth of groove 56 is set at: the major axis middle body of groove is the darkest, and is shallow more near trough rim more, promptly so-called U word groove shape (with reference to aftermentioned Fig. 9).Also can make V-shape.Groove 56 is set to the end 61 of tapering part 32.According to such structure, can discharge smoothly from the end with the urine of standing groove 56 and the wash-down water of mensuration post-flush urine usefulness.
Be provided with the extension 62a that groove top narrows down slightly, stretch out the both sides of groove above outer cover body near groove 52 and groove 54 critical.Also be provided with extension 62b, 62c on the same groove 56.These extensions 62a, 62b, 62c have the function of decision and control urine component test paper fabric width direction position.And lid is to be embedded in the state on the outer cover body 18, and the wrist 46 most advanced and sophisticated control parts 48 that are provided with of lid 20 are configured in the position of groove 50, the function of performance control urine component test paper.And a part of using head 60 up is stretched out outer cover body, also can have the function of top and control concurrently.
Like this, when being installed in urine component test paper on the shell 16, position with groove 50,52,54,56 decision end walls 58 and end portion 60 length directions, the fabric width direction position of control and decision extension 62a, 62b, 62c, the wrist 46 most advanced and sophisticated control parts 48 that are provided with of lid 20 are controlled, and these have the function that is located at test paper fixed part on the shell 16.And when the state of fixation clamp 17 with embedding was installed in urine component test paper on the shell 16, as mentioned above, the wedge-like spring leaf 40 that is arranged on fixation clamp 17 inner faces had the guiding and the fixing function of urine component test paper.
And, as the test paper fixed part except that said structure can also be: establish no hole slot on the lid, with the end of no hole slot as end portion.On outer cover body, establish the groove of bottom opening on the other hand, with its not the part of opening make it over against the end portion of lid atresia bottom land as end portion.At this moment, will be provided with the groove of the end insertion outer cover body of urine component test paper sample material, the other end inserts the no hole slot of lid.And when lid embeds outer cover body, over against end portion determine the position of urine component test paper length direction, and can rely on no hole slot or groove to fix.
Fig. 7 represent to dismantle in the portable urinalysis device 10 state of lid 20.The rectangle part 34 of the outer cover body that lid 20 embeddings is provided with the lid dismounting detector 70 that detects outer cover body 18 and dismounting lid 20.Lid dismounting detector can use automatic switch, proximity sensor etc.Lid dismounting detector 70 also can be located at the lid side.The lid of dismantling can take out the standby urine component test paper 12 that is placed on outer cover body 18 inner test paper storage chambers.
Fig. 8 is for being configured in urine component test paper 12 in the program description figure on the shell 16.(a) be the urine component test paper 12 that to install.(b) expression is installed in program on the outer cover body 18 with urine component test paper 12.(c) the fixedly pattern of urine component test paper 12 of lid 20 is lived in the expression embedding.
Above shell, the limit is by extension 62a etc. with the installed surface of sample material 14 for urine component test paper 12, and the end that sample material 14 will be installed in the limit injects the groove 56 (nothing illustrates) that covers with fixation clamp 17.And, be inserted to the depths of pushing up the portion 60 that is at the end.Then, the other end of urine component test paper 12 is aimed at the position of end wall 58.And lid 20 is embedded on the outer cover body 18, with the other end of control part 48 control urine component test papers and fixing.
Fig. 9 is that the position of portable urinalysis device 10 and urine component test paper 12 concerns key diagram.As mentioned above, the position of urine component test paper 12 is determined according to end portion 60, extension 62c etc., is configured in the groove 56 above the part subtend outer cover body 18 of sample material 14.Determine the part of the groove 56 of these sample material 14 positions to be provided with pair of conductive terminal 72a, 72b, and printing opacity detect window 74.
Figure 10 is groove 56 sectional view nearby of outer cover body 18.With pair of conductive terminal 72a, the 72b of configuration and the inside that detects the corresponding outer cover body 18 of window 74 parts, quite circuit installation room 28 is equipped with circuit substrate 75.
Pair of conductive terminal 72a, 72b are by a pair of bar-like member of measuring conductivity degree between its terminal, have the conductive material formation that detects the terminal function in the urine detector.Can use the metal bar of nickel quality surface gold-plating, the about 1mm of diameter, with the 2mm arranged spaced.Pair of conductive terminal 72a, 72b run through the outer cover body 18 of resin structure, and the one end is outstanding to groove 56, and the other end joins with the wiring figure with circuit substrate 75 such as soldering, and connecting through wiring figure does not have illustrated urine detector.The urine detector is to have the analyzer of ohmer or conductometer function or measure circuit.Pair of conductive terminal 72a, 72b can form on outer cover body 18 with inserted mode, perhaps use adhesive on outer cover body.
Under the condition of above-mentioned size, when not having conductive materials such as water to exist on pair of conductive terminal 72a, the 72b, the resistance value between its terminal is almost infinity.When having water to exist, the about 2M Ω of the resistance between its terminal.When replacing water to have urine, urinate because be electrolyte the about 100K Ω of the resistance step-down between its terminal.The resistance value of urine shows according to the electrolyte state that urine contains.So measure the resistance value between pair of conductive terminal 72a, 72b, can distinguish water and urine, judge the state of urine.
Detect window 74 and be the windowpane of printing opacity, light is injected to the sample material 14 of configuration in its position of subtend, for protection is accepted catoptrical sense light emitting-type sensor 76, made with waterproof material.Not having illustrated colour generation to measure circuit on feeling light emitting-type sensor 76 and being configured in circuit substrate is connected.1 group of light-emitting component and photo-sensitive cell are contained in the inside of sense luminescence sensor, with the optical registration sample material, receive reflected light with photo-sensitive cell by light-emitting component, and with there being illustrated colour generation mensuration circuit not measure its reflection strength, the urine that is converted into glucose in urine etc. becomes score value.
Reflection strength is different and different according to the combination of sense light emitting-type sensor 76 and luminescence assays circuit with the relation of colour generation tone.But,, can make the strong more output voltage of colour generation tone low more if during with magnitude of voltage output reflection intensity.Owing to the colour generation of sample material 14 along with the variation of placing the detection elapsed time after the urine changes, so reflection strength also with detect the elapsed time and taking place simultaneously to change.The variation that can calculate the colour generation tone according to the variation of this reflection strength variation of urinating into score value such as urine sugar value just.Order about colour generation mensuration and urine sugar value calculating etc. will describe in detail in the back.
As light-emitting component, can use LED to radiate and the colour generation wave spectrum of the sample material 14 that the is stained with urine light of appropriate wavelength mutually.In addition, on sense light emitting-type sensor 76,, be provided with a light filter that can not pass through other wavelength bands by the light-emitting component wavelength band in light-sensitive surface the place ahead of photo-sensitive cell.The light filter of this specific character also can be as the windowpane that detects window 74.In the inside of sense light emitting-type sensor 76, the boundary of light-emitting component and photo-sensitive cell also is provided with a shading wall that prevents that light from revealing.Detecting near the window 74, be provided with the temperature sensor 78 of monitoring sample material 14 environment temperatures.
Next the structure of integrated circuit is described.Figure 11 is the plate figure of integrated circuit 90.Integrated circuit 90 is interconnected in the circuit board by control circuit 92, input and output control part 94, timing portion 96 and storage part 98 and constitutes.These also can be made up of separate LSI, and are perhaps integrated by microcomputer, special-purpose LSI.Wherein a part can also be used scattered electron device.
Input and output control part 94 is I loops that button 24, sense light emitting-type sensor 76, urine detector 80, lid dismounting detector 70, temperature sensor 78 and external data processing device 100 are read in liquid crystal display 26, storage.
Timing portion 96 comprises that urine detector 80 detects the urine examination that calculate to detect the elapsed time after the urine and goes out through what timer 110 and lid dismounting detector 70 detected lid opening or loading onto the lid disassembly process timer 112 that its used time of process is calculated in the back.
Storage part 98 comprises that record urinates the composition measurement result in the past, the for example mensuration resume storage 114 of one month in the past measurement result of record, detect inject urine after, for example once urinate the computational data storage 116 of composition result of calculation every 5 seconds blotters, the elapsed time was corrected data storage 118 with the schedule time of the relevant rectification data of urine composition after record was ingested, write down the temperature characterisitic rectification data storage 120 of the rectification data relevant and be stained with the colour generation degree of interior sample material of urine back a period of time and the colour generation time rectification data storage 122 that urine sugar value concerns with demonstration with sample material colour generation temperature characterisitic.
The colour generation determination part 132 of the catoptrical reflection strength of passing back from sample material that control loop 92 comprises the luminous sense light emitting control portion 130 of sense of control light emitting-type sensor 76 sense, measure that sense light emitting-type sensor 76 receives, the reflection strength of measuring is converted into the urine composition measuring and calculating portion 134 of urine composition and carries out the display control unit 136 that liquid crystal display 26 shows control.
About the working condition of work, the particularly integrated circuit of portable urinalysis device in the example, describe with the process flow diagram of Figure 12～Figure 14.At first press power knob, carry out the initialization (S10) of integrated circuit 90.The demonstration of liquid crystal display 26, every time of timing portion 96 etc. all is reset.
Next the judgement storage is read button 24 and whether is pressed (S12).Read button 24 if press storage, according to the number of times of pressing, read over from measure resume storage 114 and urinate the composition measurement result, along with the control of display control unit 136, the demonstration of carrying out liquid crystal display 26 is switched, and demonstrates measurement result (S14) in the past.For example, storage is read button 24 by once, read and what show is the last measurement result, if by three times, will by nearest, preceding once, previous order again, read in turn and show three times determination data in the past.
Next judge whether lid dismounting detector 70 detects the opening or having loaded onto of lid (S16).The detection of dismounting is to detect opening and installing once more of lid.Like this, uncap is installed to enclosure with urine component test paper and just can confirms by electronization.When detecting the dismounting of lid, under the control of sense light emitting control portion 130, can send led control signal, make its start working (S18) to sense light emitting-type sensor 76.Judge whether to detect urine component test paper (S20) from having or not of reflected signal then.Be judged as when not detecting urine component test paper, switchable liquid crystal shows 26 demonstration, shows wrong (S22).
Judge and measure the interference component (S23) of bias light when detecting urine component test paper.Because bias light is mainly derived from sunshine, illumination light etc., the intensity of these light, wavelength are different because of the asynchronism(-nization) of measuring, and might reappearance, the reliability that colour generation is measured be impacted, so preferably remove from determination data.That is, measure earlier and be not stained with the reflection strength that to measure by urine component test paper under the urine state, be recorded in the storage.The bias light interference component of these records, afterwards colour generation is measured in (S48 etc.) and is read out from storage, removes from actual reflection strength when being stained with urine.
In addition, also be provided with the switch that can detect desheathing 16 from the fixation clamp 17 on fixation clamp 17 or the shell 16.Also can detect the mensuration of carrying out the bias light interference component when shell 16 is removed again at this switch.So just can determine the interference component when being about to inject urine.
Stop the work (S24) of sense light emitting-type sensor 76 then, the timing of lid disassembly process timer 112 begins (S26).Switchable liquid crystal shows 26 demonstration, shows lid disassembly process time T 1 (S28).Judge whether T1 arrives the schedule time of regulation, as 2 hours (S30).Can display notification (S32) when arriving the schedule time of stipulating.The demonstration of this notice both can have been used such as squeak or electronics sound and accuse it, also can make liquid crystal display 26 flickers accuse it.Uncap has been packed urine component test paper in the shell into when for example, having a meal.To it will wait by squeak and notifies you during the schedule time after ingesting, you just know that should inject in the urine component test paper this moment and have urinated.
Next judge whether to detect urine (S40).Urine is in case be stained with urine component test paper, is arranged between the pair of conductive terminal on next door and will overflows urine, and urine detector 80 just should detect unprecedented infinitely great Resistance Value, as to detect that Resistance Value increases sharply be 100k Ω.Urine detection is carried out in variation by this Resistance Value.Be judged as when detecting urine, sense light emitting-type sensor 76 is started working (S42), urine examination goes out through timer 110 to pick up counting (S44), and switchable liquid crystal shows 26, shows to detect elapsed time T2 (S46).
Colour generation determination part 132 begins to measure the catoptrical reflection strength (S48) that sense light emitting-type sensor 76 receives passes back from sample material then.When measuring reflection strength, read the bias light interference component that is recorded in storage among the S23, carry out the correction of this part.For example, from the reflection strength that the sample material that is stained with urine sends, remove the reflection strength etc. of bias light when not being stained with urine.Can use the coefficient of regulation to remove processing.Constantly reflection strength that changes and the urine that calculates afterwards become to grade data with to detect the detection elapsed time of being stained with urine corresponding, are recorded in computational data and store in 116.
The computation sequence of the mensuration of reflection strength and urine composition can be divided into 3 kinds according to the height of contained urine sugar value in the urine that drops on the sample material.Promptly, therefore can change minute according to urine sugar value because the nonlinearity of the colour generation of urine component test paper and urine sugar value concerns that along with increasing of urine sugar value, its colour generation has the characteristic that is tending towards saturated.
In Figure 15, transverse axis represents to detect the elapsed time, and the longitudinal axis is represented reflection strength, is parameter with the urine sugar value in 6 stages in the urine component test paper standard colors stave, shows reflection strength and detects relation between the elapsed time.The measurement standard time that is used for judging the urine component test paper of measuring urine sugar value is for injecting after the urine 30 seconds.As shown in FIG., in the standard colors stave +++(2000mg/dl) and ++ high urine sugar value (500mg/dl), detect the elapsed time during less than 30 seconds the variation of its reflection strength be close to saturated, bioassay standard during the time both reflection strength values very approaching, though urine sugar value is different, wherein difference is difficult to judge.On the contrary, in the standard colors stave ± (50mg/dl) and 0 (detect boundary following), spend 30 seconds even detect the elapsed time, the variation of its reflection strength is still very little, and it changes and also will continue to take place.
So as shown in figure 15, reflection strength is set two canonical measure value A, B, the reflection strength that produces according to sample material changes the time of intersecting with canonical measure value A, B, and the contained urine sugar value of sample material is divided into 3 classes.As Figure 15, canonical measure value A is set at reflection strength=4 (relative value), canonical measure value B is set at reflection strength=2 (relative value).It is long more to detect the elapsed time, and reflection strength just is tending towards low value more.High urine sugar value +++and ++ reflection strength to change be before 30 seconds bioassay standard time, all intersect with canonical measure value A and canonical measure value B.Moderate urine sugar value+and the reflection strength of (+) to change be to intersect with canonical measure value A before 30 seconds canonical measure time, but do not reduce to canonical measure value B.The variation of hanging down the reflection strength of urine sugar value (±) and 0 then is all non-intersect with canonical measure value A, canonical measure value B before 30 seconds bioassay standard time.
Return Figure 14, in colour generation is measured, determine reflection strength and detect the relation in elapsed time, judge time that reflection strength reaches canonical measure value A whether at 30 seconds with interior (S50).When being judged as in non-30 seconds, be low urine sugar value, still will continue to detect colour generation after second, determine reflection strength, calculate urine composition (S51) at the low urine sugar value minute Ta of regulation at bioassay standard time T s30.The time of Ta, 2 times of for example may be prescribed as bioassay standard time T s are 60 seconds.When calculating the urine composition, can utilize the correction table of trying to achieve in advance by the reflection strength of Ta.
The time that reflection strength reaches canonical measure value A is when being judged as in 30 seconds, then judge its time that reaches canonical measure value B whether at 30 seconds with interior (S52).When being judged as in 30 seconds, be high urine sugar value, therefore will determine the time T b that reflection strength reaches canonical measure value B, calculate urine sugar value (S53) according to Tb.When asking urine sugar value, can utilize the correction curve of trying to achieve in advance by Tb.Figure 16 is exactly an example of correction curve.Transverse axis is represented Tb among the figure, and the longitudinal axis is represented urine sugar value, the figure shows be canonical measure value B=2 (in Figure 15 for relative value) time, the relation of Tb and urine sugar value.The rectification data of using are recorded in the colour generation time rectification data storage 122, can read as required.
The time of reflection strength arrival canonical measure value A is moderate urine sugar value when being judged as in non-30 seconds, so will judge whether detection elapsed time T2 is 30 seconds.When reaching 30 seconds, calculate the urine composition of this moment.
So in a single day, calculate and urinate into score value, just the demonstration with liquid crystal display 26 switches to urine composition demonstration (S58).For example, the urine that is calculated as " 700mg/dl " becomes score value just directly to be shown.Certainly, also can be shown as according to the judgement of standard colors stave " +++2000mg/dl " etc.And the urine of calculating becomes score value will be credited to mensuration resume storage 114 as up-to-date urine composition measurement value.
But when T2 was 30 seconds, meeting was different because of urine composition value of calculating that situations such as mensuration failure obtain sometimes.At this moment, the urine that reading and recording obtained every 5 seconds in computational data storage 116 becomes score value, according to line, calculates the value of T2 when being 30 seconds, becomes score value and shows as the urine of bioassay standard time.And this numerical value will be as up-to-date urine composition measurement value record in measuring resume storage 114.
Figure 17 represents is T2 line example during data exception when being 30 seconds.Transverse axis represents to detect elapsed time T2 among the figure, and the longitudinal axis is represented urine sugar value.(a) being raw data, (b) is the data behind the line.In this example, measured once every 5 seconds in from 0 to 35 second, because the data 30 seconds sometimes the time can take place unusually, so the value can calculate T2 and be 30 seconds by the line method from other data the time.In this case, during value when adopting interpolation method to calculate T2 to be 30 seconds, colour generation is measured and preferably can be accomplished more than 30 seconds.Value in the time of also can using extrapolation to calculate T2 to be 30 seconds.At this moment, colour generation is measured and can be finished in the time of 30 seconds.
Return Figure 14, finish, can take out the urine component test paper of using, need to clean portable urinalysis device then from enclosure if the urine composition calculates.At this, judge whether to have detected washing lotion (S60).In a single day washing lotion is injected in the shell, will be overflowed by water between the pair of conductive terminal, and detect the urine detector 80 that is about 100k Ω Resistance Value before, should detect its surge this moment and be the Resistance Value of 2M Ω.Utilize Resistance Value to change the detection of carrying out washing lotion.Washing lotion is judged as when detecting, and stops the work of sense light emitting-type sensor 76, the demonstration of liquid crystal display 26 is switched to clean.Do not show that when having cleaned, i.e. expression is not also cleaned or clean insufficient, need to continue to clean.
More than be normal process, but between the S40 of the S28 to Figure 13 of Figure 12, lid disassembly process time T 1 is the schedule time of regulation, for example 2 hours.Before reaching in 2 hours, just may be stained with urine (among Figure 13 shown in the S70) on the urine component test paper, or opposite T1 surpasses and just is stained with urine after 2 hours on the urine component test paper.At this moment, read the relevant rectification data of the schedule time and urine composition from schedule time rectification data storage 118, the lid disassembly process time T 1 when determining to be stained with urine is revised the urine of the schedule time of regulation then and is become score value.
Figure 18 represents is correction example about the schedule time.Transverse axis is represented the lid disassembly process time among the figure, and the longitudinal axis is represented urine sugar value.(a) being is 1 hour measured value the lid disassembly process time, (b) is the relevant rectification data of the schedule time and urine composition, and will replace with the lid disassembly process time this moment schedule time.(c) expression be will (a) the measured value rectification data of contrasting (b) revise, calculate the lid disassembly process time and be 2 hours urine sugar value.
In addition, read the relevant rectification data of the temperature characterisitic of sample material colour generation from temperature characterisitic is corrected data storage 120, according to the detected temperatures of temperature sensor 78, the urine in the time of can revising standard temperature and spend as 20 becomes score value.
In addition, Resistance Value or conductance by the urine that determines of urine detector can show in liquid crystal display.
[embodiment 2]
Next, with regard to other examples, illustrate with Figure 19 to Figure 24.The characteristics of this example are accumulated portion and will urinates from urine and accumulate portion's water conservancy diversion to the urine stream that detects window for be provided with concavity urine in outer cover body, also are provided with the electric conductivity terminal whether a pair of detection is stained with urine urinating on the stream.
Figure 19 is the vertical view of outer cover body 218, and is corresponding with Fig. 4 (a) of front.With the identical part of Fig. 4 (a), its symbol marks too, and has saved detailed explanation.But the size of figure is bigger than Fig. 4 (a).On outer cover body 218, look along long direction, groove 50,52 is arranged, urine accumulates portion 250 and urine stream 252.Urine stream 252 is arranged at from urine and accumulates portion 250 on the direction that detects window 74, the width of width and urine component test paper much at one, for example its width design is than the wide 0.2mm of urine component test paper.In addition, in urine stream 252, its 61 the place aheads, end have also disposed a pair of baffle plate 254a that dwindles stream, 254b.Though they put into the position of urine component test paper corresponding to enclosure, it is more much bigger than the width of urine component test paper that but urine accumulates the width of portion 250, when portion put into urine component test paper in the enclosure, can there be enough big depression the both sides of urine component test paper, and make this shape.
In addition, the urine on urine stream 252 accumulates portion's 250 directions, has also disposed the electric conductivity terminal 272a of a pair of mutually insulated, 272b.This a pair of electric conductivity terminal 272a, 272b, the position difference that is provided with just, the electric conductivity terminal 72a of explanation such as its function and Fig. 9 etc., 72b is identical, promptly with urinate detector and be connected, the variation by the conductivity degree between the electric conductivity terminal detects whether be stained with urine.
Figure 20 is a position relation between outer cover body 218 and the urine component test paper 12 to Figure 22 explanation, and is corresponding with Fig. 9 of front.Figure 20 is a vertical view, expression be on outer cover body 218, the state that the urine component test paper 12 that shows with the method for 2 lines is placed.Figure 21, Figure 22 are the sectional views of outer cover body 218, corresponding to the AA line of Figure 20 and the section of BB line.The part identical with Fig. 9, symbol marks too, and has saved detailed explanation.But the size of figure is bigger than Fig. 9.As shown in the figure, urine accumulates portion 250 makes outer cover body 218 that a very big depression be arranged, and for example its width is compared with urine component test paper 12, is designed to be about its 6 times.The extending area 256a, the 256b that are provided with near the urine stream 252 that detects the window 74 are provided with for the baffle plate with 254a, 254b determines the position of urine component test paper together.
Figure 23 is that the urine of outer cover body 218 accumulates near the sectional view portion 250 and the urine stream 252, and is corresponding with Figure 10 of front.The part identical with Figure 10, symbol marks too, and has saved detailed explanation.But the size of figure is bigger than Figure 10.As shown in the figure, pair of conductive terminal 272a, 272b are arranged on apart from urine and accumulate on the very near urine stream 252 of portion 250.The height setting of baffle plate 254a, 254b is slightly higher than the thickness of the sample material 14 of urine component test paper 12.Promptly between baffle plate 254a, 254b and extending area 256a, 256b, sandwich urine component test paper 12, when fixing its position,, set the height of baffle plate 254a, 254b in order to allow sample material 14 and detect between the window 74 and to keep certain slit.
What Figure 24 illustrated is to possess urine to accumulate portion 250, urine stream 252 and pair of conductive terminal 272a, the isostructural effect of 272b.Place urine component test paper 12 in outer cover body 18, will urinate 300 enclosure of packing into, urine will exist urine to accumulate in the depression of portion 250.The urine 302 of storage is by narrow urine stream 252, as used urine 61 discharges from the end at last.The direction that is further appreciated that urine 300 injections from Figure 24 is opposite with sample material 14 placed sides of urine component test paper 12.Promptly urinate 300 and can not directly touch sample material 14.Even in this case, by being set, urine accumulates portion 250 and urine stream 252, and also can be sample material 14 sufficient urine is provided.
Baffle plate 254a, 254b cause the stream stenosis of urine stream 252 narrow, that is to say, urine is accumulated portion 250 from urine and flowed out under pressure state.On urine stream 252, the sample material of urine component test paper 12 14 and detect window 74 slit of part is narrow and small in opposite directions, when the surface tension of urine played a role, urine just was difficult to flow.At this, utilize to have stored a large amount of urines and to have had the pressure that the urine of certain volume accumulates between portion and baffle plate 254a, the 254b and can get rid of capillary influence, allow urine at sample material 14 and detect between the window 74 and flow through smoothly.
Accumulate portion's 250 1 sides because pair of conductive terminal 272a, 272b are set at the urine of urine stream 252, so beginning to inject urine at 300 o'clock, whether urine does not also flow through urine stream 252 and arrives before the sample material 14, just can detect urine and be injected into.When detecting when being injected into for urine, send led control signals to sense light emitting-type sensor 76, it is started working, can before the luminescence assays of sample material 14, determine the interference component that bias light causes, more definite remove the interference that bias light causes.The mensuration (S23) that bias light disturbs in the process flow diagram of Figure 12 is exactly to carry out when urine component test paper has been placed on enclosure detecting in front.
To be stained with urine be benchmark to detect, and can adjust to sense light emitting-type sensor 76 and send led control signals, the time that it is started working.For example, can be stained with urine after a period of time detecting, send led control signals to sense light emitting-type sensor 76 again, it is started working.The delay of this section period can be set at: after urine arrives sample material 14, the part that sample material 14 is stained with urine contains the urine color, such as after colourless ~ yellow ~ redness etc., send led control signals to sense light emitting-type sensor 76 again, it is started working.When being about to that sample material 14 carried out luminescence assays, can determining and contain the interference component that the bias light of urinating color causes.Set this section during the period, consider to accumulate portion 250 to sample material, promptly feel the distance of the position of light emitting-type sensor 76 from urine, and the flow path resistance of urine stream 252 etc.These can be determined by experiment in advance.
The width of urine stream 252, detect window 74 near, that set as mentioned above and width urine component test paper much at one, so outside astigmatism can reduce the influence to luminescence assays from urine component test paper both sides income.
More than at portable urinalysis device, the situation of just using a test paper front end to place a kind of urine component test paper of sample material is illustrated, but the present invention also can use a test paper to place the urine component test paper of multiple sample material.For example, having placed with urine sugar value, protein, ERY on the test paper is 3 kinds of sample materials of total of detected object, this moment, the window that detects with portable urinalysis device was made as 3, regulate separately sense light emitting-type sensor according to the colour generation characteristic of sample material (light filter that the wavelength of light-emitting component, photo-sensitive cell are used) separately.And the setting urine examination goes out the bioassay standard of process timer during the time, protein detection is made as is stained with urine after 10 seconds, ERY is detected to be made as be stained with urine after 20 seconds.Make optimal setting according to the difference of detected object like this, just can carry out multinomial urine constituent analysis substantially simultaneously.
[embodiment 3]
Next further describe with regard to the portable urinalysis device 310 of example.The principal feature of portable urinalysis device 310 is with shadow shield 317 urine component test paper 12 to be blocked, and bias light is measured colour generation do not impacted.The outward appearance of portable urinalysis device 310 shows by Figure 25 (vertical view), Figure 26 (front elevation), Figure 27 (ground plan) respectively.Portable urinalysis device 310 is by outer cover body 318, and the lid 320 and the buckle that have clip 319 are formed at the shadow shield 317 of outer cover body 318 bottoms.At the position that they are in contact with one another, be the water proofing property of guaranteeing that it is intact, the ad hoc damascene structures of having counted.
Outer cover body 318 is that a rectangular section roughly approaches foursquare elongated case shape parts, has the water proof type basket function that the integrated circuit that calculates the urine composition etc. is taken in inside.The outer cover body 318 that uses can be made by resin forming.On the length direction of outer cover body 318, an end is to have the damascene structures that the lid 320 of clip 319 embeds fully, and the bottom of the other end is the damascene structures that shadow shield embeds fully.In addition, above outer cover body 318,, the horn-like opening 351 of a perforation is arranged, be used for injecting urine to the bottom surface.At this, because outer cover body 318 has embedded shadow shield 317 fully, by acting in conjunction, the urine of injection is just saved bit by bit formation and is deposited urine 350.
The liquid crystal display 326 that is arranged on the bottom surface of outer cover body 318 is to show the display screen of urinating into score value and urine examination survey elapsed time etc.Be arranged on LED380 above the outer cover body 318 and be and have demonstration and injected the urine examination of the function of urine state and go out display screen.Inject the kind of urine state, can be set at the state that injects urine that detects, through the state after the stipulated time, not inject the state of urine etc. after the injection urine, LED380 has according to its status categories and changes display packing, shows the function that is in which kind of state.For example, enough urines have been arranged, do not needed to continue again to inject, but be difficult to again under the situation of observation urine memory state, just observed easily not much with the luminous of LED380 in the urine portion of accumulating of portable urinalysis device 310 many times.When urine was accurately injected, the lamp of LED380 will be bright, passes through the stipulated time then, and when the urine portion of accumulating had stored abundant urine, the lamp of LED380 will be coruscated, and urinates composition at last and calculate when finishing, and the lamp of LED380 will extinguish.Particularly for the women, the state of LED380 shows very effective.Concrete example will be introduced in the back.Both can use LED light-emitting component in addition, also can show the state that is stained with urine with luminous difference of multiple color.
In outer cover body 318 bottom surfaces that shadow shield 317 embeds, except the outlet of above-mentioned horn-like opening 351, also be provided with fixing urine component test paper 12 directed parallel, printing opacity detect window and for pair of conductive terminal of detecting urine etc., its details will be described in detail in the explanation of shadow shield 317 embedded parts.
Lid 320 is parts of opening or being installed in outer cover body 318 1 ends, both can change the battery that is contained in outer cover body 318 inside by it, also can take out urine component test paper.Lid 320, one ends have the rectangular-shaped opening that embeds outer cover body 318, are a flat column parts that seal on one side substantially.The lid 320 here can be made by resin forming.
Lid 320 embeds the part of outer cover body 318, is represented by Figure 28 to Figure 30.At this, Figure 28 and Figure 30 are front view (FV)s, and Figure 29 is a ground plan, demonstration be state when the diagrams direction of arrow in outer cover body 318 upper edges is pulled up lid 320.Peristome is provided with a pair of extension arm, is provided with the button 384 that slides in the extension arm inboard.The button 384 that slides is corresponding with a pair of Long Circle guiding groove 382 that is arranged on outer cover body 318 both sides, along moving of Long Circle guiding groove 382 guiding lids 320, and has the effect that limits its moving range.Promptly with Figure 28, the direction that arrow shown in Figure 29 is opposite is fully mobile, be entrenched togather fully in the mosaic texture that outer cover body 318 will not have in the drawings to show with lid 320, and fully mobile along the direction of arrow, lid 320 also can not break away from from outer cover body 318.
Like this,, as shown in figure 29, move lid 320, just can expose the battery installation section position that is contained in inside, outer cover body 318 bottom surface along the direction of arrow by the effect of a pair of Long Circle guiding groove 382 and a pair of slip button 384.At this, can change battery as required.And behind the fully mobile lid 320 of the direction of arrow shown in Figure 28, the rotation direction of arrow rotation lid 320 according to shown in Figure 30 then is arranged at test paper storage chamber 327 inner above the outer cover body 318 and just has been opened.Can from test paper storage chamber 327, take out new urine component test paper 12 as required like this.
The subsidiary clip 319 of lid 320 to be located and is provided with in order portable urinalysis device 310 to be stuck at one's side as pocket etc., so just can make portable urinalysis device 310 keep approaching the temperature of body temperature always, when detecting the urine composition, can make the temperature of the temperature of urine and portable urinalysis device 310 approaching.Know all that generally the colour generation of urine component test paper has temperature dependency, so the temperature of utilizing this clip that portable urinalysis device 310 is kept near body temperature can make the detection of urine composition more stable.
Shadow shield 317 is to embed the parts of outer cover body 318 bottom surfaces and outer cover body 318 together by acting in conjunction, decides and the fixing position of urine component test paper 12.Also be to have the urine of formation to accumulate the parts of portion's 350 functions as mentioned above.Shadow shield 317 for embedding the shape of outer cover body 318 bottom surfaces and two sides, be substantially the parts that elongated shape three faces have wall.The shadow shield 317 here can adopt the material with shading performance to make by resin forming.The shading performance makes it reach the degree that not disturbed by bias light when measuring urine component test paper and gets final product with covering outer light.For example the synthetic resin of black or have the synthetic resin of abundant obstruct light thickness also can use the synthetic resin that posts the shading black thin film.
With regard to the part of shadow shield 317 embedding outer cover bodies 318, represent by Figure 31, Figure 32.Here Figure 31 is a front view (FV), and Figure 32 is a ground plan, demonstration be the state of extracting shadow shields 317 from outer cover body 318 along the diagram directions of arrow out.As Figure 31 and shown in Figure 32, the parallel walls of shadow shield 317 both sides partly has the function of a pair of guiding groove 388 guiding that are set at outer cover body 318 bottom surfaces, and shadow shield 317 can move according to Figure 31, the direction of arrow shown in Figure 32 along the profile of outer cover body 318 bottom surfaces thus.Move according to the direction of arrow, do not have the scope restriction, shadow shield 317 can be taken off from outer cover body 318.Move according to the arrow reverse direction, its scope is restricted because of the skew wall that is arranged on the outer cover body 318.
Shadow shield 317 with the top of the opposite side of joint of the skew wall 340 of outer cover body 318, the discharge urine outlet 361 of the urine by urine component test paper 12 is arranged.Urine exports 361 the rectangle that is shaped as, and its width setup is slightly wideer than the width of urine component test paper 12.
About setting-in each parts of bottom surface of outer cover body 318 of shadow shield 317, will describe, comprising the acting in conjunction of shadow shield 317 and outer cover body 318.
Be provided with the outlet of horn-like opening 315 in the bottom surface of outer cover body 318, from here along the length direction of outer cover body 318 towards the other end, be provided with 2 in turn and detect window 374 and pair of conductive terminal 372.Also be provided with pair of parallel guiding 356 then, they are clipped in wherein.
Detecting window 374 is the transparent glass windows with waterproof construction, and purpose is light to be injected the sample material 14 of urine component test paper 12, receives reflected light.In outer cover body 318 inboards that detect window 374, for the colour generation of measuring sample material 14 is provided with sense light emitting-type sensor.2 detect window 374 and are set at separately and 2 kinds of sample materials, 14 corresponding positions.
Pair of conductive terminal 372 is to be arranged on the outer cover body 318, and a pair of bar-like member that is made by conductive material that is provided with that a part of projection comes in outer cover body 318.In the inside of outer cover body 318 the urine detector is housed, and this a pair of electric conductivity terminal 372 is coupled.
The bottom surface of outer cover body 318, the pair of parallel guiding 356 that projection is provided with has the fixedly function of urine component test paper 12.The section of directed parallel 356 is two bossings that symmetry is arranged on the major axis of outer cover body 318.Parallel interval between these two bossings is: it is slightly wideer than sample material 14 that the parallel interval of close outer cover body 318 bottom surfaces one side is set, slightly narrower than urine component test paper 12, the width of the ratio urine component test paper of then setting away from the parallel interval of outer cover body 318 bottom surfaces 12 is slightly wide.By this structure, pair of parallel guiding 356 is fixing urine component test paper 12 just, makes sample material 14 towards outer cover body 318 bottom surfaces one side.
This has the setting of the directed parallel 356 of protruding track, on its set positions and outer cover body 318 setting-ins during shadow shield 317 position of urine outlet 361 corresponding.Promptly on the directed parallel 356 that protruding track is arranged fixedly during urine component test paper 12, the extended line of urine component test paper 12 is just in time corresponding with the position of urine outlet 361.Rephrase the statement, the setting that is exactly these configurations is exactly at the good shadow shield 317 of outer cover body 318 setting-ins, during from urine outlet 361 insertion urine component test papers 12, can just in time by the directed parallel 356 that bossing is arranged urine component test paper 12 is fixed.
Introduce below pack into the concrete operation method of portable urinalysis device 310 of urine component test paper 12.At first shown in figure 32 with shadow shield 317 always depth push outer cover body 318.When urine component test papers 12 are inserted in the urine outlet 361 that is arranged on shadow shield 317 other ends, make bottom surface one side of sample material 14 then, promptly insert facing to the direction that detects window 374 towards outer cover body 318.The one straight cutting urine component test paper 12 that goes down will arrive the skew wall 340 of outer cover body 318, advances to the outside of outer cover body 318 along the inclined-plane.In suitable place, slack from outer cover body 318 twitch urine component test papers 12 until it, decide its position.
Figure 33 is the sectional view of an expansion, demonstration be between outer cover body 318 and shadow shield 317, the decision and the fixing position of urine component test paper, the embedding outer cover body 318 that shadow shield 317 is firm injects the state of urines 300 from horn-like opening 351.As mentioned above, because shadow shield 317 embeds outer cover body 318 fully, horn-like opening 351 places have formed urine and have accumulated portion 350, urine 302 in this storage, flow into the bottom surface and the shadow shield 317 inboard urine streams 352 that form of outer cover body 318, by being fixed on the sample material 14 of the urine component test paper 12, sample material 14 is produced and the corresponding colour generation of urine composition there.The urine of urine stream 352 continues to flow, and arrives pair of conductive terminal 372, further discharges as used urine from urinating outlet 361.
The colour generation of sample material 14 is an intermediary to detect window 74, measures by sense light emitting-type sensor 376, calculates the urine composition by the urine composition measuring and calculating portion that does not show among the figure.If according to said structure, outer cover body 318 and shadow shield 317 are inlaid in together fully, and then in sample material 14 parts of urine component test paper 12, exterior light will be covered fully.Like this, just suppress the disturbing effect that colour generation is caused by bias light in measuring, can carry out the processing such as bias light interference measurement of explanation among the embodiment 1.
Sense light emitting-type sensor 376 is elements that inside comprises one group of light-emitting component and photo-sensitive cell, to sample material 14 projection lights, collects reflected light by photo-sensitive cell from light-emitting component, has the function of measuring its reflection strength.The selection of the wave spectrum of light-emitting component will be considered the urine color of being stained with on the colour generation spectrum of sample material 14 and the sample material 14.Promptly according to the medicament kind difference on the sample material, even the urine of being stained with is identical, the tone of colour generation, promptly wave spectrum is also inequality.And the color of well-known urine also is various.To correctly measure colour generation, preferably in the colour generation wave spectrum scope when sample material 14 is stained with urine, use the light of not urinated the wavelength that color influences to measure reflection.
Figure 34 represents is to use certain sample material, is injected with the urine of 4 kinds of colors, observes the appearance of its wave spectrum.In Figure 34, the longitudinal axis is represented the reflection strength that photo-sensitive cell mensuration draws, and transverse axis is represented wavelength, shows the variation of reflection strength according to wavelength.The color of urine normally from water white transparency to deep or light different yellow, but be known as the iridescent of the jaundice green of vitamin urine in addition in addition, be called the brown of bilirubinuria, present red or the like as blood urine.In Figure 34, common dark urine 102 below the 100mg/dl condition of the sample material 400 that injects before the urine, urine sugar value, vitamin urine 404, the light color urine 406 and the wave spectrum of water white transparency urine 408 have usually usually been shown respectively.In addition, because showing, red urine and brown urine may suffer from disease, so from the comparison of Figure 34, removed.In this sample material example, as shown in figure 34, the wavelength in the 500-520nm scope, the wave spectrum of colour generation is not urinated the influence of color.As example, use emission wavelength spectrum has the light-emitting component of crest in the 500-520nm scope, and photo-sensitive cell is preferably in the light filter that its front setting can see through 500-520nm light.
The minute of colour generation and measured value being handled it when calculating the urine composition, there is several method available.Specifically, the control part of portable exactly urinalysis device 310 is equipped with several urine composition calculation procedures, can be according to user's needs, or, select a kind of program automatically according to the state-detection result that state sensors such as being loaded on the temperature inside sensor draws.
Urine composition computing method.(1) according in the bioassay standard time of regulation, for example is stained with the method that the colour generation of urine after 30 seconds calculates the urine composition.When (2) urine sugar value is high, being benchmark with the colour generation that is shorter than the bioassay standard time, is the method that benchmark calculates the urine composition with the colour generation of being longer than the bioassay standard time when urine sugar value is low.These two kinds of methods illustrate in embodiment 1.
At this, what need further specify is that (3) measure the method for extrapolating the urine composition of bioassay standard during the time by the colour generation of a plurality of minutes, and (4) consider that the temperature difference between urine temperature and the portable urinalysis unit temp calculates the method for urine composition.
Measure the method for the urine composition of extrapolating the bioassay standard time by the colour generation of a plurality of minutes, be meant at bioassay standard and set a plurality of minutes in the time, be determined at the colour generation of minute point separately, then and the correction curve of trying to achieve in advance compare, obtain and urinate composition the most accurately.Figure 35 is exactly the example of correction curve, and transverse axis represents to detect the time of having injected after the urine, promptly detects the elapsed time, and the longitudinal axis is represented reflection strength, and this figure shows is the standards change curve of glucose in urine degree when changing.For example, the bioassay standard time is decided to be 30 seconds, minute is set at 6 times, be respectively to detect elapsed time=0, and 5,15,20,25,30 seconds, each reflection strength that detects the elapsed time point is measured.Each reflection intensity data that will obtain then and the correction curve of Figure 35 are done and are contrasted, and infer out change curve the most accurately.In the bullet example of Figure 35, urinate composition the most accurately and be estimated to be glucose in urine degree 100mg/dl (±).Choosing of minute both can be as above-mentioned, and every certain interval of time is measured primary event intensity, also can continue to measure its reflection strength, and the reflection strength according to certain intervals determines the elapsed time again.
Like this measured value and correction curve are being contrasted, when consistance is enough high, can all measure, can omit later mensuration after calculating presumed value on the way according to minute.In the example of Figure 35, because when detecting 20 seconds elapsed time, just can fully infer out, so later mensuration can be omitted.Estimate the correction curve consistance, when calculating the most accurately change curve, can use statistical methods such as well-known least square method.
Next calculating the method for urinating composition with regard to the temperature difference between consideration urine temperature and the portable urinalysis unit temp describes.At first, illustrate it is which influence is reflection strength have that the temperature difference of urinating between temperature and the portable urinalysis unit temp is measured colour generation.The longitudinal axis is represented reflection strength among Figure 36, and transverse axis represents to detect the time of injecting after the urine, and what this figure showed is to get portable urinalysis unit temp to be respectively 5 ℃, 20 ℃, 40 ℃, when injecting the urine of glucose in urine degree 100mg/dl on the urine component test paper, the time of reflection strength changes.Here urine is " moment injection ", that is to say urine moment injected the horn-like opening 351 of portable urinalysis device after, just will annotate the urine device and remove.At this moment, the temperature of urine and body temperature much at one, but the urine volume that sample material absorbs seldom, thermal capacity is very little, so if the temperature of portable urinalysis device is low, urine will cool down very soon, can suppress color reaction.On the contrary, if the temperature of portable urinalysis device approaches body temperature, urine will keep temperature, and color reaction will keep usual condition.Like this, although be same urine, if the temperature of urine temperature and portable urinalysis device has gap, difference will take place in reflection strength, and the time, long more its difference was also big more.
Someone proposes to prolong the time that urine injects, cannot carrying out colour generation mensuration then at short notice? based on this idea, test, its result shows in Figure 37.The longitudinal axis of Figure 37, transverse axis and Figure 36 are the same, and the glucose in urine degree of the urine of use also is 100mg/dl, and is the same with Figure 36, and sample material is also used identical.Be decided to be in this time that will inject urine and detect urine and be injected into back 3 seconds, and then remove and annotate the urine device.From the result of Figure 37, after 7 seconds in, even the temperature of portable urinalysis device changes between 5-40 ℃, what difference is its reflection strength also can't see.And can confirm even continue to inject urine, begin 4-9 between second from being detected when urine is injected, what influence is temperature that can't see portable urinalysis device have to reflection strength.
Begin 4-9 between second from detecting when urine is injected, carry out the several colour generation and measure, infer out with above-mentioned correction curve and urinate composition the most accurately, so just can reduce the influence of the temperature difference between urine temperature and the portable urinalysis device.At this, when injecting, urine begins the 4-9 time range of second from detecting, and by the capacity of depositing urine, the urine flow flowing mode of urine stream is about institute such as the thermal capacity of portable urinalysis device.Consider this point, best experimental set out first stipulated time and second stipulated time, continue at least to inject urine more than 3 seconds, get a plurality of minutes from first stipulated time to second stipulated time, measure based on its colour generation, calculate the urine composition.
If use Figure 25, shown in Figure 33 be arranged at outer cover body 318 above, promptly urine injects first stipulated time that the LED380 of a side accuses and second stipulated time etc., it is very convenient to become.Figure 38 is exactly the lamp flicker situation that shows that LED380 changes along with detecting the detection elapsed time after urine injects.In Figure 38, also demonstrated the luminescence assays state that the urine examination of urinating injection timing, electric conductivity terminal 372 does well and feels light emitting-type sensor 376.Promptly begin to inject a period of time after the urine, urine will arrive electric conductivity terminal 372, carries out urine examination and goes out.With this is starting point t constantly constantly 0Measure and detect the elapsed time.LED380 begins bright lamp when to, tell mensuration person's urine by intact injection, and sample material begins moistening, can continue to inject.Continue afterwards to inject urine, from t 0Began to be for 3 seconds moment T 1, this moment, LED380 will transfer flicker to from bright lamp.Promptly tell mensuration person,, injected abundant urine, can remove and annotate the urine device, but also can continue to inject in order to reduce the influence of the temperature difference between urine temperature and the portable urinalysis device.Because from moment T 1Begin the moment T after 7 seconds 2Between, be the very little segment limit of temperature difference influence, be t so got for first stipulated time therein 1=4 seconds, second stipulated time was t 2=9 seconds, between this, light sense light emitting-type sensor 376, carry out colour generation and measure.After colour generation was measured and finished, the lamp of LED380 will extinguish.In the example of Figure 38, be at moment T 2In time, extinguish.The colour generation of telling mensuration person to need is thus measured and is finished, if outer cover body 318 is turned over, just can see the urine composition that shows in the liquid crystal display 326 of bottom surface.
In above-mentioned colour generation is measured, just use the sense light emitting-type sensor that is arranged on outer cover body inside to measure catoptrical method and be illustrated, also light-emitting component and photo-sensitive cell can be separated into outer cover body one side and shadow shield one side at this, measure printing opacity.In this case, light-emitting component one side will be loaded onto waterproof construction, and mosaic site etc. is located between shadow shield and outer cover body, and be provided with can conversion electric power and the interface of signal.By separating light-emitting component and photo-sensitive cell, the configuration of---sample material---photo-sensitive cell of can taking light-emitting component makes the maintenance certain intervals between light-emitting component and the photo-sensitive cell.When inserting urine component test paper,, cause the sample material position between light-emitting component and photo-sensitive cell, to misplace like this, also can reduce colour generation is measured the influence that causes even its location is wrong.
In the above-mentioned explanation, urine component test paper 12 being positioned in the process of portable urinalysis device 310, is a side of taking urine component test paper 12 from hand, and promptly relative with bar-shaped sample material 14 an is set side begins to insert urine outlet 361.In addition, also can begin to insert urine outlet 361 from the side that urine component test paper 12 is provided with sample material 14.The bossing 357 of location usefulness is set in the shadow shield 317 in this case.Its shape shows in Figure 39 and Figure 40.Figure 39 is corresponding to Figure 32, and Figure 40 is corresponding to Figure 33.Urine component test paper 12 inserts the urine outlet 361 of shadow shield 317 from a side that is provided with sample material 14.Then, be inserted into the position that inner bossing 357 decides urine component test paper 12 always.In this structure, as long as shadow shield is done unidirectional moving according to the direction of arrow shown in Figure 40 to outer cover body 318, urine component test paper 12 will move along the direction of arrow by the effect of bossing 357, can take out urine component test paper 12 easily.
The possibility of the utilization of the present invention on industry also can be used as analyst and animal body fluid, as ingredients such as blood, sweat, urines, or the portable analytical equipment of ingredient etc. in the upper and lower water course, plant chimney stalk, soil.

Claims (8)

1. portable specimen analyzing device, it is characterized in that: described device has the waterproof construction shell of the handle part that can singlehanded control, be located on the above-mentioned shell and tip portion has the test paper fixed part of the bar-shaped colour generation test paper of fixed preparation colour generation sample material, from above-mentioned shell projection and be located at above-mentioned test paper fixed part nearby and the pair of conductive terminal of mutually insulated, the conductivity degree of measuring between above-mentioned pair of conductive terminal detects the sample detector of placing sample thus, calculate the sample that above-mentioned sample detector detects the detection elapsed time behind the sample and detect, represent that the above-mentioned detection elapsed time reaches the standard time of above-mentioned colour generation bioassay standard time of metering through display part through timer; Above-mentioned sample detector and above-mentioned sample detect through timer and are arranged on above-mentioned waterproof construction enclosure.
2. according to the portable specimen analyzing device of claim 1, it is characterized in that: described device is to have the sample that is located at sample setting side, expression sample laying state to detect announcer.
3. portable urinalysis device, it is characterized in that: described device has the waterproof construction shell of the handle part that can singlehanded control, be located on the above-mentioned shell and tip portion has the fixedly test paper fixed part of the bar-shaped urine component test paper of urine colour generation sample material, outstanding and be located at above-mentioned test paper fixed part nearby and the pair of conductive terminal of mutually insulated from above-mentioned shell, the conductivity degree of measuring between above-mentioned pair of conductive terminal detects the urine detector of placing urine thus, calculate above-mentioned urine detector and detect the urine examination that detects the elapsed time after the urine and go out, represent that the above-mentioned detection elapsed time reaches the standard time of the bioassay standard time of measuring above-mentioned colour generation through display part through timer; Above-mentioned urine detector and above-mentioned urine examination go out through timer to be located at above-mentioned waterproof construction enclosure.
4. portable urinalysis device, it is characterized in that: described device has the waterproof construction shell of the handle part that one hand can control, be located on the above-mentioned shell and tip portion has the test paper fixed part of the bar-shaped urine component test paper of fixing urine colour generation sample material, be located on the above-mentioned shell, accumulate the spill urine of placing urine and accumulate portion, outstanding and be located at above-mentioned test paper fixed part nearby and the pair of conductive terminal of mutually insulated from above-mentioned shell, the conductivity degree of measuring between above-mentioned pair of conductive terminal detects the urine detector of placing urine thus, calculate above-mentioned urine detector and detect the urine examination in the detection elapsed time after the urine and go out through timer, represent the above-mentioned detection elapsed time reach calculate the above-mentioned colour generation bioassay standard time standard time through display part; Above-mentioned urine detector and above-mentioned urine examination go out through timer to be located at above-mentioned waterproof construction enclosure.
5. according to the portable urinalysis device of claim 3 or 4 any records, it is characterized in that: described device has the urine examination that is arranged on the laying state of placing urine side, expression urine and goes out announcer.
6. according to claim 3 or 4 described portable urinalysis devices, it is characterized in that: described device is that above-mentioned shell comprises that inside has the outer cover body of the test paper storage chamber of placing above-mentioned urine component test paper, can be from above-mentioned outer cover body dismounting, cover the lid of the above-mentioned urine component test paper gateway of above-mentioned test paper storage chamber, said sample material fixed part has lid side fixed part that is located on the lid and the base side fixed part that is located on the above-mentioned outer cover body, relies on the body fixed part that covers the side fixed part and be located on the outer cover body to determine above-mentioned urine component test paper position.
7. portable urinalysis device according to claim 6, it is characterized in that: described device has the lid dismounting detector that detects the lid dismounting, the lid disassembly process timer of calculating lid disassembly process time during from the dismounting lid represents that the above-mentioned lid disassembly process time reaches predefined urine and places the schedule time of the schedule time through display part.
8. according to claim 3 or 4 described portable urinalysis devices, it is characterized in that: described device is the value that above-mentioned urine detector is exported above-mentioned conductivity degree when placing urine.
CN2006100814857A 2004-04-09 2004-04-09 Portable specimen analysing device and portable urine analysing device Expired - Fee Related CN1869694B (en)

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KR101257299B1 (en) 2009-09-09 2013-04-22 한국전자통신연구원 The potable digital reader for urine detection
CN107389954A (en) * 2017-07-28 2017-11-24 武汉市安友泽瑞科技有限公司 Interstitialcellstimulating hormone (ICSH) ELISA test strip pen
CN107356767A (en) * 2017-07-28 2017-11-17 武汉市安友泽瑞科技有限公司 Interstitialcellstimulating hormone (ICSH) test strips analyzer
CN115856284B (en) * 2022-12-15 2023-11-28 西交利物浦大学 Chromatographic test strip with bionic flow channel and application thereof

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