CN1868504A - Method for preparing Weigan Futai capsule for treating liver complaint - Google Patents
Method for preparing Weigan Futai capsule for treating liver complaint Download PDFInfo
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- CN1868504A CN1868504A CN 200510026110 CN200510026110A CN1868504A CN 1868504 A CN1868504 A CN 1868504A CN 200510026110 CN200510026110 CN 200510026110 CN 200510026110 A CN200510026110 A CN 200510026110A CN 1868504 A CN1868504 A CN 1868504A
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- extractum
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- gallus domesticus
- fructus schisandrae
- schisandrae chinensis
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Abstract
A process for preparing the Chinese medicine 'Weiganfutai capsule', an improvement to its tablet, features that the extracts of schisandra fruit and Taihe chicken are dried in vacuum condition and the ginsenoside and conk polyose are dried by spray for retaining their active components to maximum.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of preparation method of Weigan Futai capsule for treating liver complaint.
Background technology
Hepatitis B (abbreviation hepatitis B) is the liver inflammatory damage that is caused by hepatitis B virus (abbreviation hepatitis B virus), is a kind of infectious disease that China's current popular is the most extensive, harm is the most serious.The level of economic development is lower, and sanitary condition is poor to be the popular basis of primary disease.The primary disease extend over the entire globe, hepatitis B surface antigen (Australia antigen) carrying rate, the torrid areas is higher than the temperate zone, and the male is higher than the women, and in the country without immunoprophylaxis, child's carrying rate is higher than the adult, and the city often is higher than the rural area.The source of infection mainly is patient and the asymptomatic carrier of hepatitis B virus, all is the important way of propagating through blood, property contact and close contact of living.The susceptible person infects behind the hepatitis B virus approximately through 6 morbidities in thoughtful 6 months.Clinical manifestation is weak, loss of appetite, feels sick, vomits, detests oil, diarrhoea and abdominal distention, and some cases has heating, jaundice, the concealment of half patient onset is arranged approximately, in the middle discovery of having a medical check-up.Abnormal liver function, serum hepatitis B surface antigen, hepatitis B virus DNA (deoxyribonucleic acid), hepatitis B virus immune globulin M, deoxyribonucleic acid polymerase is all positive.Most of hepatitis B can be fully recovered after controlling in acute stage, and a lot of case courses of disease delay or transfer to chronic, and wherein a part can develop into posthepatitic cirrhosis even hepatocarcinoma; The development of the only a few case course of disease is swift and violent, and hepatocyte occurs large stretch of downright bad, becomes hepatitis gravis; Other has some the infecteds then to become asymptomatic virus carrier.
The Chinese medicine chronic hepatitis B has the incomparable unique advantage of Western medicine.The compound Chinese medicinal preparation that the safe sheet of dimension liver good fortune is made up of stem and leaf of Radix Ginseng saponin, Ganoderma Applanatum Polysaccharides, Gallus Domesticus extractum, Fructus Schisandrae Chinensis extractum four Chinese medicine, has nourishing the liver and kidney, the effect of supplementing QI and nourishing YIN, be used for the treatment of chronic hepatitis B, chronic persistent hepatitis, liver cirrhosis, and the hepatic injury that causes of various chemical toxicants, but there is the shortcoming that disintegrate is slow, onset is slow in tablet, and existing needs improved place.
Summary of the invention
Technical problem to be solved by this invention is the safe tablet form of former dimension liver good fortune is improved, on the basis that the primary standard revision improves, change tablet into capsule, accelerated the onset time of medicine, improve bioavailability, satisfied the demand of extensive patients better.Ensured the quality of medicine, made this product meet the regulation of the medicine registration management way of national Bureau of Drugs Supervision, this medicine exports, going to the world provides the quality assurance in order to make.It is characterized in that:
Medical material (by weight percentage) prescription is: the stem and leaf of Radix Ginseng saponin 11.5%, Ganoderma Applanatum Polysaccharides 44.9%, and Gallus Domesticus extractum 21.8%, Fructus Schisandrae Chinensis extractum 21.8%,
The preparation method of Weigan Futai capsule for treating liver complaint disclosed by the invention comprises the following steps:
1) Ganoderma Applanatum Polysaccharides: get Ganoderma applanatum (Pers. Ex Wallr) Pat. and be ground into coarse powder, put in the extraction pot, soak 1.5 hours after, decoct three times, add 12 times of amounts of water at every turn, decocted 5 hours, decocting liquid filters, and merging filtrate is concentrated into relative density 1.10 (60 ℃), ultrafiltration, 60 ℃ of dryings of filtrate are pulverized, promptly;
2) Gallus Domesticus extractum: after getting Gallus Domesticus and slaughtering, immerse in the boiled water, remove unhairing, pawl, intestinal and feces, clean, be cut into small pieces, put into pot, flood (about about 3 times) with clear water, decoct three times, each 5 hours, decocting liquid filtered, merging filtrate, being concentrated into relative density is the extractum of 1.25～1.35 (75 ℃, the 1kg Gallus Domesticus gets extractum 200g approximately);
3) Fructus Schisandrae Chinensis extractum: get schisandra chinensis medicinal material and be ground into coarse powder, add alcohol reflux three times, 4 hours for the first time, second and third time 2 hours, with 2 times of amount ethanol, extracting solution filters at every turn, filtrate recycling ethanol, be concentrated into the extractum of relative density 1.20～1.30 (70 ℃, the 1kg Fructus Schisandrae Chinensis gets extractum 230g approximately), promptly;
4) finished product preparation: take by weighing stem and leaf of Radix Ginseng saponin, Ganoderma Applanatum Polysaccharides, Gallus Domesticus extractum, Fructus Schisandrae Chinensis extractum and starch by recipe quantity, mix homogeneously, drying under reduced pressure (60～70 ℃, 0.09Mpa), to pulverize, the system granule incapsulates, promptly.
The preparation for preparing with the present invention:
1, character: this product is a capsule, and content is the yellowish-brown granule; Bitter in the mouth.
2, disintegration time shortens: disintegration time tablet average out to 23 minutes, capsule average out to 12 minutes shortens nearly 1 times than former dosage form.
The disintegration time contrast table
| Dosage form | Average disintegration time |
| Weigan Futai capsule for treating liver complaint | 12 minutes |
| The safe sheet of dimension liver good fortune | 23 minutes |
3, dissolution rate is accelerated: tablet peaked at 30 minutes, and capsule peaked at 20 minutes, shifted to an earlier date 10 minutes than tablet.
The dissolution contrast table
| Time | 5 | 10 | 15 | 20 | 25 | 30 | 60 |
| Weigan Futai capsule for treating liver complaint | 27.2 | 39.0 | 41.7 | 50.9 | 50.8 | 52.0 | 52.1 |
| The safe sheet of dimension liver good fortune | 11.0 | 20.5 | 30.5 | 37.4 | 44.0 | 51.3 | 52.0 |
4, quality standard improves: compare with former dosage form, following improvement has been arranged: (1), increased the qualitative identification of Fructus Schisandrae Chinensis in the prescription, revised stem and leaf of Radix Ginseng saponin's qualitative identification in the prescription.(2), the colorimetric method for determining total saponin content is risen to ginsenoside Rg in the content of monomer mensuration-high effective liquid chromatography for measuring preparation
1, Re sum content, have more specificity.
Weigan Futai capsule for treating liver complaint and the safe tablet quality standard of former dosage form dimension liver good fortune contrast table
| Dosage form | Qualitative identification | Assay |
| Weigan Futai capsule for treating liver complaint | Stem and leaf of Radix Ginseng saponin, Fructus Schisandrae Chinensis | The ginsenoside Rg 1, Re content sum |
| The safe sheet of dimension liver good fortune | The stem and leaf of Radix Ginseng saponin | Total saponins |
5, novel form is compared with former dosage form, clear and definite every critical technical parameter, and every technology carried out preferably.
The specific embodiment
Below the present invention is further described:
Prescription: stem and leaf of Radix Ginseng saponin 18g, Ganoderma Applanatum Polysaccharides 70g, Gallus Domesticus extractum 34g, Fructus Schisandrae Chinensis extractum 34g
Feedstock production:
1.18g the method for making of Fructus Schisandrae Chinensis extractum: get schisandra chinensis medicinal material and be ground into coarse powder, add alcohol reflux three times, 4 hours for the first time, second and third time 2 hours is at every turn with 2 times of amount ethanol, extracting liquid filtering, filtrate recycling ethanol, be concentrated into the extractum of relative density 1.20～1.30 (70 ℃, the 1kg Fructus Schisandrae Chinensis gets extractum 230g approximately), promptly.
2.34g the method for making of Gallus Domesticus extractum: after getting Gallus Domesticus and slaughtering, immerse in the boiled water, remove unhairing, pawl, intestinal and feces, clean, be cut into small pieces, put into pot, flood (about about 3 times) with clear water, decoct three times, each 5 hours, decocting liquid filtered, merging filtrate, being concentrated into relative density is the extractum of 1.25～1.35 (75 ℃, the 1kg Gallus Domesticus gets extractum 200g approximately).
3.70g the method for making of Ganoderma Applanatum Polysaccharides: get Ganoderma applanatum (Pers. Ex Wallr) Pat. and be ground into coarse powder, put in the extraction pot, soak 1.5 hours after, decoct three times, add 12 times of amounts of water at every turn, decocted 5 hours, decocting liquid filters, and merging filtrate is concentrated into relative density 1.10, ultrafiltration, 60 ℃ of dryings of filtrate are pulverized, promptly.This product contains Ganoderma Applanatum Polysaccharides with glucose meter, must not be lower than 37%.
Finished product preparation: get by recipe quantity and take by weighing Fructus Schisandrae Chinensis extractum, Gallus Domesticus extractum mix homogeneously, add medical starch 200g, mixing, drying, pulverize, add stem and leaf of Radix Ginseng saponin and Ganoderma Applanatum Polysaccharides and dry medical starch 60g, mixing, pack in No. 1 capsulae vacuus, make 1000, promptly.
Its active ingredient content contrast
1, measures ginsenoside Rg in 9 batches of stem and leaf of Radix Ginseng saponin's raw materials respectively
1, the Re total content, testing result shows that all raw materials all meet respective standard, ginsenoside Rg
1With ginsenoside Re's total amount all greater than 30%.See following table for details
Ginsenoside Rg in stem and leaf of Radix Ginseng saponin's raw material
1, Re total content (%)
2, ginsenoside Rg in the finished product
1, Re sum assay, to ginsenoside Rg in ten batch samples
1, the Re total content measures, and the results are shown in following table.Consider the practical situation of production, so limit is decided to be:
Every of this product contains the ginsenoside Rg
1, the Re sum must not be less than 5mg.
Ginsenoside Rg in ten batches of finished products
1, Re total content (mg/ grain)
Claims (1)
1, a kind of preparation method of Weigan Futai capsule for treating liver complaint is characterized in that:
Medical material (by weight percentage) prescription is: the stem and leaf of Radix Ginseng saponin 11.5%, Ganoderma Applanatum Polysaccharides 44.9%, Gallus Domesticus extractum 21.8%, Fructus Schisandrae Chinensis extractum 21.8%;
This preparation method comprises the following steps:
1) Ganoderma Applanatum Polysaccharides: get Ganoderma applanatum (Pers. Ex Wallr) Pat. and be ground into coarse powder, put in the extraction pot, soak 1.5 hours after, decoct three times, add 12 times of amounts of water at every turn, decocted 5 hours, decocting liquid filters, and merging filtrate is concentrated into relative density 1.10 (60 ℃), ultrafiltration, 60 ℃ of dryings of filtrate are pulverized, promptly;
2) Gallus Domesticus extractum: after getting Gallus Domesticus and slaughtering, immerse in the boiled water, remove unhairing, pawl, intestinal and feces, clean, be cut into small pieces, put into pot, flood (about about 3 times) with clear water, decoct three times, each 5 hours, decocting liquid filtered, merging filtrate, being concentrated into relative density is the extractum of 1.25～1.35 (75 ℃, the 1kg Gallus Domesticus gets extractum 200g approximately);
3) Fructus Schisandrae Chinensis extractum: get schisandra chinensis medicinal material and be ground into coarse powder, add alcohol reflux three times, 4 hours for the first time, second and third time 2 hours, with 2 times of amount ethanol, extracting solution filters at every turn, filtrate recycling ethanol, be concentrated into the extractum of relative density 1.20～1.30 (70 ℃, the 1kg Fructus Schisandrae Chinensis gets extractum 230g approximately), promptly;
4) finished product preparation: take by weighing stem and leaf of Radix Ginseng saponin, Ganoderma Applanatum Polysaccharides, Gallus Domesticus extractum, Fructus Schisandrae Chinensis extractum and starch by recipe quantity, mix homogeneously, drying under reduced pressure (60～70 ℃, 0.09Mpa), to pulverize, the system granule incapsulates, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510026110 CN1868504A (en) | 2005-05-24 | 2005-05-24 | Method for preparing Weigan Futai capsule for treating liver complaint |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510026110 CN1868504A (en) | 2005-05-24 | 2005-05-24 | Method for preparing Weigan Futai capsule for treating liver complaint |
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| CN1868504A true CN1868504A (en) | 2006-11-29 |
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| CN 200510026110 Pending CN1868504A (en) | 2005-05-24 | 2005-05-24 | Method for preparing Weigan Futai capsule for treating liver complaint |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012528144A (en) * | 2009-05-26 | 2012-11-12 | 株式会社アモーレパシフィック | Saponin bioavailability enhancing composition |
| CN106344728A (en) * | 2016-11-07 | 2017-01-25 | 张田田 | Hepatitis B treatment capsules and preparation method thereof |
-
2005
- 2005-05-24 CN CN 200510026110 patent/CN1868504A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012528144A (en) * | 2009-05-26 | 2012-11-12 | 株式会社アモーレパシフィック | Saponin bioavailability enhancing composition |
| US10172900B2 (en) | 2009-05-26 | 2019-01-08 | Amorepacific Corporation | Composition with improved bioavailabilty of saponin and method for improving the bioavailability of saponin |
| CN106344728A (en) * | 2016-11-07 | 2017-01-25 | 张田田 | Hepatitis B treatment capsules and preparation method thereof |
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