CN1861073A - Use of malic polyphenols for preparing medicine to treat pharyngolaryngitis - Google Patents
Use of malic polyphenols for preparing medicine to treat pharyngolaryngitis Download PDFInfo
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- CN1861073A CN1861073A CN 200510200274 CN200510200274A CN1861073A CN 1861073 A CN1861073 A CN 1861073A CN 200510200274 CN200510200274 CN 200510200274 CN 200510200274 A CN200510200274 A CN 200510200274A CN 1861073 A CN1861073 A CN 1861073A
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Abstract
An application of malic polyphenol in preparing the medicine and/or health-care food for preventing pharyngitis, laryngitis, tonsillitis, etc is disclosed.
Description
Technical field
The medicine that the present invention relates to apple polyphenol is newly used, and be specifically related to apple polyphenol and preparing treatment and preventing the medicine of following respiratory system disease and/or the application in the health product: pharyngitis, laryngitis, tonsillitis belong to natural medicine field.
Background technology
Pharyngitis, laryngitis, tonsillitis are main, common upper respiratory diseases, the sickness rate height, and difficult healing the, especially chronic pharyngolaryngitis, it is more difficult to treat, and almost becomes the pertinacious disease of respiratory tract.Present Western medicine and Chinese medicine, therapeutic effect are all undesirable, and is all the more so to chronic pharyngolaryngitis.For these respiratory tract diseases, still lack effective radical cure measure.Therefore, it is very important seeking a kind of natural drug that has remarkable therapeutic effect and have no side effect.
Apple polyphenol is the polyphenols that extracts from Fructus Mali pumilae, and especially immature Fructus Mali pumilae (green apple) content is more, from economic angle, generally never extracts in the transparent apple.
The Main Ingredients and Appearance of apple polyphenol has: Fructus Mali pumilae procyanidin (Grape Procyanidins), and about 50% (this is the main active ingredient of apple polyphenol), existing at present content is at the Fructus Mali pumilae procyanidin more than 80%; Chlorogenic acid about 25%; Catechin, epicatechin about 15%; Other polyphenol about 10%.
The Fructus Mali pumilae procyanidin is the main active ingredient of apple polyphenol, and existing at present content is at the Fructus Mali pumilae procyanidin more than 80%.
The extracting method of apple polyphenol belongs to mature technology, and there are the commodity of apple polyphenol in domestic many enterprises at present, and content is more than 80%, and many commodity content are higher than 95%.
The known effect of apple polyphenol has antioxidation, anticancer, arteriosclerosis, hair growth promoting, antibiotic, antiviral.Up to the present, the relevant apple polyphenol of Shang Weijian is used for the treatment of pharyngitis, laryngitis, tonsillitic report.
Summary of the invention
The purpose of this invention is to provide the new medicinal application of apple polyphenol, promptly apple polyphenol is treated or/and prevent the medicine of following respiratory system and/or the application in the health product in preparation: pharyngitis, laryngitis, tonsillitis.
More specifically, application of the present invention is characterized in that described " medicine and/or health product " are medicine.Also promptly, application of the present invention, it is characterized in that apple polyphenol in preparation treatment or/and prevent application in the medicine of following respiratory system disease: pharyngitis, laryngitis, tonsillitis.
More specifically, application of the present invention is characterized in that described " treatment is or/and prevention " is treatment.Also promptly, application of the present invention is characterized in that the application of fruit polyphenol in the medicine of the following respiratory system disease of preparation treatment: pharyngitis, laryngitis, tonsillitis.
Application of the present invention, feature is more specifically:
Application of the present invention is characterized in that described respiratory system disease is a pharyngitis, also is the application of apple polyphenol in the medicine of preparation treatment pharyngitis.
Application of the present invention is characterized in that described respiratory system disease is a laryngitis, also is the application of apple polyphenol in the medicine of preparation treatment laryngitis.
Application of the present invention is characterized in that described respiratory system disease is a tonsillitis, also is the application of apple polyphenol in the tonsillitic medicine of preparation treatment.
Application of the present invention, described pharyngitis are chronic pharyngitis.
Application of the present invention, described pharyngitis are acute pharyngitis.
Application of the present invention, described laryngitis are chronic laryngitis.
Application of the present invention, described laryngitis are acute laryngitis.
Application of the present invention, described tonsillitis are chronic tonsillitis.
Application of the present invention, described tonsillitis are acute tonsillitis.
Application of the present invention, the described respiratory system disease that treats and/or prevents especially treats and/or prevents pharyngitis or laryngitis, comprises cleaning throat and moistening larynx." cleaning throat and moistening larynx " be not though this notion is strict clinical medicine medical concept or efficacy of drugs notion, but in the health food effect of China State Food and Drug Administration regulation, determined " cleaning throat and moistening larynx ", this is treatment or prevents pharyngitis, laryngitis to explain in the effect of health product category, therefore, the present invention uses this notion.
Application of the present invention, the described respiratory system disease that treats and/or prevents especially treats and/or prevents pharyngitis and/or laryngitis, comprises improving pharyngeal discomfort and/or improving throat's discomfort, also promptly improves the bottleneck throat discomfort." improve pharyngeal discomfort " and " improving the bottleneck throat discomfort " though clinical medicine medical concept or the efficacy of drugs notion that this notion neither be strict often used " improving pharyngeal discomfort " or " improving the bottleneck throat discomfort " effect and indication with statement medicine or health product in China's medicine or health food effect sign.In view of this is sanctified by usage and set notion, therefore, the present invention uses this notion.
The health food that " cleaning throat and moistening larynx ", " improving pharyngeal discomfort " and " improving the bottleneck throat discomfort " are to use medicine or biologically active is in pharyngitis and laryngitis treatment or the healthcare process, the improvement of pharyngeal and throat's malaise symptoms.
Application of the present invention, described apple polyphenol are the Fructus Mali pumilae total polyphenols.
Application of the present invention, described apple polyphenol are the Fructus Mali pumilae procyanidin.The Fructus Mali pumilae procyanidin is tool active ingredient in the apple polyphenol, also is the effective constituent that mainly contains of apple polyphenol.
Application of the present invention, described apple polyphenol are extract.It also can be the former plant that contains apple polyphenol.
Application of the present invention, described apple polyphenol comprise apple polyphenol derivant.
Described derivant comprises the polymer of apple polyphenol, and apple polyphenol is by the product of methods such as physics, chemistry acquisition, such as salt, the ester of apple polyphenol.
The preparation method of apple polyphenol extract has multiple, and multiple report is arranged, and belongs to known technology and maturation process, and existing many commodity sellings.
The apple polyphenol or derivatives thereof all can be used as preparation and treats and/or prevents pharyngitis, laryngitis, tonsillitic medicine and/or health product.
Application of the present invention, described medicine oral administration, Sublingual, external, transdermal, injection, instillation, mucosa, spraying, transfusion, rectum or parenterai administration.
Application of the present invention, the administration of described health product oral administration.
Apple polyphenol or derivatives thereof of the present invention, be that medicine is or/and the main active constituent of health product, when the preparation dosage form, can also comprise that adding one or more is selected from excipient substances such as conventional excipient, flavoring agent, disintegrating agent, antiseptic, lubricant, wetting agent, binding agent, solvent, thickening agent, solubilizing agent, makes any dosage form that is suitable for drug use clinically or uses as health product.
Application of the present invention, described medicine are tablet, pill, capsule, granule, liposome, oral liquid, injection, infusion solution, aerosol or nasal drop.
Application of the present invention, described health product are oral formulations.
Application of the present invention, the mass percentage content of described apple polyphenol in medicine and/or health product is 1% to 100%.
Application of the present invention is characterized in that the mass percentage content of described apple polyphenol in medicine and/or health product is 20% to 95%.
Application of the present invention is characterized in that the mass percentage content of described apple polyphenol in medicine and/or health product is 50% to 80%.
Application of the present invention, the implication of described " medicine and/or health product " are that apple polyphenol can be used to prepare medicine, also can be used to prepare health product; The preparation of apple polyphenol preparation can be used as drug use, also can be used as health product and uses.
Because apple polyphenol extracts from common edible fruits Fructus Mali pumilae, does not have poison, therefore can be applied to health product.Described health product comprise health food, health care medicine.
Effect of the present invention
One, physical data
This group patient 30 examples are through hospital diagnosis and make a definite diagnosis.Pharyngitis 12 examples (chronic 9 examples, acute 3 examples wherein; Simple property 5 examples in the chronic pharyngitis, hypertrophic 2 examples, atrophic type 2 examples), laryngitis 10 examples (chronic 7 examples, acute 3 examples; Simple type 4 examples, hypertrophic 2 examples in the chronic laryngitis, atrophic type 1 example), tonsillitis 8 examples (chronic 6 examples, acute 2 examples).Man's 10 examples, women 20 examples, minimum 14 years old of age, maximum 70 years old; 39 years old mean age; The course of disease of chronic patient is the longest 29 years, the shortest person 2 years, average course of disease 15.2 years.
Two, Therapeutic Method
Use apple polyphenol (the Fructus Mali pumilae procyanidin content is more than 60%) capsule (not adding excipient), oral one time 3 (every 0.4 gram), 3 times on the one, one after each meal, 30 days one courses of treatment of chronic patients, the acute patient treated 7 days, did not take other drug during taking.
Three, efficacy assessment standard
1, the efficacy assessment standard of pharyngitis:
(1) chronic pharyngitis
Observe the change situation of patient's body card and symptom.
The body card is main to be observed: pharyngeal hyperemia, pharynx lymph follicle, vocal congestion, pachyderma circumscripta.
Symptom is mainly observed: dry pharynx, pharynx are stifled, foreign body sensation, pharynx burning sensation, itching throat, pharyngalgia, hoarseness.
Cure: pharyngeal sign is no abnormal, transference cure;
Take a turn for the better: pharyngeal unusual sign is obviously improved, and symptom obviously alleviates;
Invalid: pharyngeal unusual sign does not have obvious improvement, and symptom does not have obviously and alleviates.
(2) acute pharyngitis
Observe the change situation of patient's body card and symptom.
Body card and symptom are mainly observed: mucous hyperemia, swelling, lateral pharyngeal band redness, retropharyneal folliculosis, pharyngalgia, heating sense.
Cure: transference cures such as pharyngalgia, heating, pharyngeal body card recovers normal.
Take a turn for the better: symptoms such as pharyngalgia, heating, pharyngeal swelling obviously alleviate, and the body card is basic to be improved.
Invalid: symptom does not have obviously and alleviates, and the body card does not have obviously and improves.
2, the efficacy assessment standard of acute, chronic laryngitis:
Cure: hoarseness is alleviated, and it is normal that vocal congestion, swelling and vocal cords outward appearance are recovered;
Take a turn for the better: hoarseness alleviates, and vocal congestion, swelling and vocal cords outward appearance are normal substantially;
Invalid: hoarseness and vocal cords outward appearance do not have obvious improvement.
3, tonsillitic efficacy assessment standard:
(1) chronic tonsillitis
Observe the change situation of patient's body card and symptom.
Body card and symptom are mainly observed: the acute tonsillitis of showing effect repeatedly, and pharyngeal discomfort, foreign body sensation, dry, itch pharyngalgia, irritable cough, antiadoncus, pharyngeal congestion.
Cure: body card and transference cure, do not show effect in 3 months.
Take a turn for the better: symptom obviously alleviates, and the body card is basic to be improved.
Invalid: symptom does not have obviously and alleviates, and the body card does not have obviously and improves.
(2) acute tonsillitis:
Observe the change situation of patient's body card and symptom.
Body card and symptom are mainly observed: antiadoncus, pharyngeal congestion, pharyngalgia, heating etc.
Cure: the symptomatologies such as pharyngalgia in 7 days, heating of taking medicine disappear disappearances such as antiadoncus, pharyngeal congestion.
Take a turn for the better: the symptoms such as pharyngalgia in 7 days, heating of taking medicine obviously alleviate, and antiadoncus, pharyngeal congestion etc. are obviously alleviated.
Invalid: the symptoms such as pharyngalgia in 7 days, heating of taking medicine do not alleviate substantially, and antiadoncus, pharyngeal congestion do not have obvious alleviation.
Four, therapeutic outcome
1, clinical symptoms, sign change relatively (example) before and after the treatment
(1) pharyngitis symptom, sign change, and " moistening and cleaning throat " effect that has also can be described or to the improvement of pharyngeal discomfort
| Before the treatment | After the treatment | |
| The stifled foreign body sensation pharynx of pharyngeal hyperemia pharynx lymph follicle injection of vocal cord pachyderma circumscripta dry throat pharynx burning heat sensation is swallowed the pharyngalgia hoarsen of itching | 9 11 10 8 12 7 12 11 10 9 7 | 1 2 2 1 0 0 0 1 0 0 |
(2) laryngitis symptom, sign change, and " wetting one's whistle " effect also can be described or to the improvement of throat's discomfort
| Hoarseness | Vocal congestion | Vocal cords swelling | |
| After treating before the treatment | 9 0 | 10 1 | 10 1 |
(3) tonsillitis symptom, Signs change
| Before the treatment | After the treatment | |
| The dry pharyngalgia irritable cough antiadoncus congestion of throat of itching of pharyngeal uncomfortable foreign body sensation | 8 6 7 5 8 6 7 6 | 0 0 1 1 1 1 1 1 |
2, therapeutic effect statistics
| Group | The example number | Cure | Take a turn for the better | Invalid | Total effective rate | |
| The example number | The example number | The example number | The example number | ％ | ||
| Pharyngitis | 12 (chronic 9) | 8 | 3 | 1 | 11 | 91.6 |
| Laryngitis | 10 (chronic 7) | 5 | 4 | 1 | 9 | 90.0 |
| Tonsillitis | 8 (chronic 6) | 5 | 2 | 1 | 7 | 87.1 |
The specific embodiment
Embodiment 1
Apple polyphenol 800 grams
Lactose 200 grams
Above-mentioned component is stirred, encapsulated, every filling 0.5 gram.Make 2000 of apple polyphenol capsules, every capsules contains 400 milligrams of apple polyphenols.
Embodiment 2
Apple polyphenol 1000 grams
Apple polyphenol is encapsulated, every filling 0.5 gram.Make 2000 of the former polyphenol capsules of Fructus Mali pumilae, every capsules contains 500 milligrams of apple polyphenols.
Embodiment 3
Apple polyphenol 800 grams
Starch 200 grams
Above-mentioned component is stirred, encapsulated, every filling 0.5 gram.Make 2000 of capsules that contain apple polyphenol, every capsules contains 400 milligrams of apple polyphenols.
Embodiment 4
Apple polyphenol 600 grams
Starch 200 grams
Sucrose 200 grams
Above-mentioned component is stirred, moistening, tabletting.Make the apple polyphenol tablet.
Embodiment 5
Apple polyphenol 250 grams
2000 milliliters of distilled water
Stevioside 1 gram
Apple polyphenol is dissolved in stirring and evenly mixing in the distilled water, adds stevioside, stirring and evenly mixing, bottling, every bottled 10 milligrams, sterilization makes oral liquid.
Embodiment 6
Apple polyphenol 400 grams
Starch 200 grams
Sucrose 300 grams
Xylitol 100 grams
Above-mentioned component is stirred, moistening, tabletting.Make the apple polyphenol buccal tablet.
Industrial applicability
The present invention has enlarged the range of application of apple polyphenol, has improved its exploitation and has been worth. Prepare treatment and preventing pharyngitis, laryngitis, tonsillitic medicine and/or health products with apple polyphenol of the present invention, the preparation method is simple, raw material is easy to get, and has industrial applicibility.
Claims (10)
1. apple polyphenol is treated or/and prevent the medicine of following respiratory system disease and/or the application in the health product in preparation: pharyngitis, laryngitis, tonsillitis.
2. according to the application of claim 1, it is characterized in that apple polyphenol in the preparation treatment or/and prevent application in the medicine of following respiratory system disease: pharyngitis, laryngitis, tonsillitis.
3. according to the application of claim 2, it is characterized in that the application of fruit polyphenol in the medicine of the following respiratory system disease of preparation treatment: pharyngitis, laryngitis, tonsillitis.
4. according to claim 1,2 or 3 arbitrary described application, it is characterized in that described respiratory system disease is a pharyngitis.
5. according to claim 1,2 or 3 arbitrary described application, it is characterized in that described respiratory system disease is a laryngitis.
6. according to claim 1,2 or 3 arbitrary described application, it is characterized in that described respiratory system disease is a tonsillitis.
7. according to claim 1,2 or 3 arbitrary described application, it is characterized in that described apple polyphenol is the Fructus Mali pumilae procyanidin.
8. according to claim 1,2 or 3 arbitrary described application, it is characterized in that described " treat and/or prevent and/or prevent " respiratory system disease comprises cleaning throat and moistening larynx or improves pharynx/throat's discomfort.
9. according to claim 1,2 or 3 arbitrary described application, it is characterized in that described medicine or health product comprise tablet, pill, capsule, granule, liposome, oral liquid, injection, infusion solution or aerosol.
10. according to the application of claim 9, it is characterized in that the mass percentage content of described apple polyphenol in medicine and/or health product is 20% to 95%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510200274 CN1861073A (en) | 2005-05-12 | 2005-05-12 | Use of malic polyphenols for preparing medicine to treat pharyngolaryngitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510200274 CN1861073A (en) | 2005-05-12 | 2005-05-12 | Use of malic polyphenols for preparing medicine to treat pharyngolaryngitis |
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| Publication Number | Publication Date |
|---|---|
| CN1861073A true CN1861073A (en) | 2006-11-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200510200274 Pending CN1861073A (en) | 2005-05-12 | 2005-05-12 | Use of malic polyphenols for preparing medicine to treat pharyngolaryngitis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115919917A (en) * | 2022-12-27 | 2023-04-07 | 广东医科大学 | New use of apple and towel gourd juice and alcohol precipitation extract in clearing and moistening throat |
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2005
- 2005-05-12 CN CN 200510200274 patent/CN1861073A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115919917A (en) * | 2022-12-27 | 2023-04-07 | 广东医科大学 | New use of apple and towel gourd juice and alcohol precipitation extract in clearing and moistening throat |
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