CN1853685B - Pearl guttural tablets - Google Patents
Pearl guttural tablets Download PDFInfo
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- CN1853685B CN1853685B CN2005100497091A CN200510049709A CN1853685B CN 1853685 B CN1853685 B CN 1853685B CN 2005100497091 A CN2005100497091 A CN 2005100497091A CN 200510049709 A CN200510049709 A CN 200510049709A CN 1853685 B CN1853685 B CN 1853685B
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- extractum
- powder
- pearl
- fructus mume
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- 239000000843 powder Substances 0.000 claims abstract description 63
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 51
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 50
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 26
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 25
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 24
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000001630 malic acid Substances 0.000 claims abstract description 24
- 235000011090 malic acid Nutrition 0.000 claims abstract description 24
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 44
- 244000293323 Cosmos caudatus Species 0.000 claims description 44
- 239000006189 buccal tablet Substances 0.000 claims description 33
- 229940046011 buccal tablet Drugs 0.000 claims description 32
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 23
- 244000228451 Stevia rebaudiana Species 0.000 claims description 23
- 235000006092 Stevia rebaudiana Nutrition 0.000 claims description 23
- 239000000600 sorbitol Substances 0.000 claims description 23
- 239000003826 tablet Substances 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 1
- 239000007937 lozenge Substances 0.000 abstract description 16
- 239000000284 extract Substances 0.000 abstract description 3
- -1 sortitol Chemical compound 0.000 abstract 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- 235000007877 Diospyros australis Nutrition 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 240000002577 Prunus nigra Species 0.000 abstract 1
- 235000010875 Prunus nigra Nutrition 0.000 abstract 1
- 235000018288 Vitex doniana Nutrition 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 239000008187 granular material Substances 0.000 description 33
- 241000699670 Mus sp. Species 0.000 description 19
- 238000002360 preparation method Methods 0.000 description 18
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 16
- 239000000203 mixture Substances 0.000 description 16
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 15
- 230000003248 secreting effect Effects 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 10
- 230000008961 swelling Effects 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 206010013786 Dry skin Diseases 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000007779 soft material Substances 0.000 description 8
- 238000005303 weighing Methods 0.000 description 8
- 229920001525 carrageenan Polymers 0.000 description 7
- 230000037396 body weight Effects 0.000 description 6
- 235000010418 carrageenan Nutrition 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 5
- 239000010839 body fluid Substances 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
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- 230000003203 everyday effect Effects 0.000 description 4
- 108010084652 homeobox protein PITX1 Proteins 0.000 description 4
- 238000005286 illumination Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
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- 210000003437 trachea Anatomy 0.000 description 4
- 241000475481 Nebula Species 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 241000201295 Euphrasia Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
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- 238000007619 statistical method Methods 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
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- 238000011835 investigation Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
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- 231100000614 poison Toxicity 0.000 description 1
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- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A buccal lozenge for clearing throat contains proportionally pearl powder, the extracts of black plum and liquorice root, menthol, sortitol, malic acid, rebandioside, magnesium stearate and alcohol.
Description
(1) technical field
The invention provides a kind of pearl guttural tablets.
(2) background technology
Put down in writing according to Compendium of Material Medica and Chinese Pharmacopoeia 2000 editions (186 pages): " the Margarita nature and flavor: sweet, salty, cold, GUIXIN, Liver Channel." function is the arresting convulsion of calming the nerves, the removing nebula that makes eye bright, removing toxic substances and promoting granulation.Be used for the palpitation with fear insomnia, the infantile convulsion epilepsy, order is given birth to nebula, and skin infection is not put a body into a coffin.Modern study, Margarita contain calcium carbonate and 20 various trace elements and taurine, 18 seed amino acids etc. more than 90%.Margarita has multiple efficacies: eliminating toxin and beautifying the skin, activity are replenished the calcium, hypnotic, adjust blood pressure, enhance immunity, the removing nebula that makes eye bright, relieving constipation.Other medicinal functions of Margarita are still waiting further research at present.
(3) summary of the invention
The present invention is for a kind of pearl lozenge with function of moistening and cleaning throat is provided, and this buccal tablet sugar content is low, and mouthfeel is good, the shelf-life steady quality.
For reaching goal of the invention the technical solution used in the present invention be:
A kind of pearl guttural tablets, described buccal tablet is composed as follows:
Margarita powder 1000～5000 mass fractions (g)
Fructus Mume extract 100～1000 mass fractions (g)
Radix Glycyrrhizae extract 100～2000 mass fractions (g)
Mentholum 100～1000 mass fractions (g)
Sorbitol 100～7000 mass fractions (g)
Malic acid 100～3000 mass fractions (g)
Sweetleaf centautin 0.1～10 mass fraction (g)
Magnesium stearate 10～50 mass fractions (g)
Ethanol 20 volume parts (mL).
Further, described buccal tablet is composed as follows:
Margarita powder 1000～5000 mass fractions (g)
Fructus Mume extractum 100～1000 mass fractions (g)
Radix Glycyrrhizae extractum powder 100～2000 mass fractions (g)
Mentholum 100～1000 mass fractions (g)
Sorbitol 100～7000 mass fractions (g)
Malic acid 100～3000 mass fractions (g)
Sweetleaf centautin 0.1～10 mass fraction (g)
Magnesium stearate 10～50 mass fractions (g)
Ethanol 20 volume parts (mL)
Fructus Mume water carried or alcohol extraction 2～3 times, it is 1.2～1.4kg/L that merge extractive liquid, is concentrated into proportion, promptly gets described Fructus Mume extractum.
Concrete, described buccal tablet per 10000 composed as follows:
Margarita powder 1000～5000g
Fructus Mume extractum 100～1000g
Radix Glycyrrhizae extractum powder 100～2000g
Mentholum 100～1000g
Sorbitol 100～7000g
Malic acid 100～3000g
Sweetleaf centautin 0.1～10g
Magnesium stearate 10～50g
Ethanol 20mL.
Preferably, described buccal tablet per 10000 composed as follows:
Margarita powder 3000g
Fructus Mume extractum 120g
Radix Glycyrrhizae extractum powder 400g
Mentholum 100g
Sorbitol 6085g
Malic acid 250g
Sweetleaf centautin 2g
Magnesium stearate 43g
Ethanol 20mL.
The beneficial effect of pearl guttural tablets of the present invention is mainly reflected in: a kind of pearl guttural tablets prescription is provided, and described buccal tablet has antiinflammatory and promoting the production of body fluid for nourishing the lung effect; Gained buccal tablet good stability, and the raw materials used Sugarless type that is, sugar content is low; The simple cost of preparation technology is low, is fit to suitability for industrialized production.
(4) specific embodiment
The present invention is described further below in conjunction with specific embodiment, but protection scope of the present invention is not limited to this:
Used Fructus Mume extractum is that proportion is the Fructus Mume extractum of 1.2kg/L in the embodiment of the invention, Fructus Mume water is carried 2 times, and merge extractive liquid,, being evaporated to proportion is that 1.2kg/L gets final product.
Embodiment 1:
Prescription:
Margarita powder 3000g
Fructus Mume extractum 120g
Radix Glycyrrhizae extractum powder 400g
Mentholum 100g
Sorbitol 6085g
Malic acid 250g
Sweetleaf centautin 2g
Magnesium stearate 43g
Ethanol 20mL
Make 5000.
Preparation:
(1) at first respectively Margarita powder is taken by weighing 3000 grams, Radix Glycyrrhizae extractum powder 400 grams, sweetleaf centautin 2 gram mix homogeneously, add Fructus Mume extractum 120 again and restrained 18 mesh sieve system soft materials.Again the wet granular that obtains 60 ℃ of dryings two hours, after 20 order granulate, it is standby to obtain dried granule;
(2) again Mentholum 100 is restrained in the ethanol that is dissolved into 20 milliliters, this solution is being sprayed onto on the dried granule of above-mentioned preparation airing under the room temperature;
(3) tabletting behind step (2) gained granule and sorbitol 6085 grams, magnesium stearate 43 grams, the malic acid 250 gram mix homogeneously promptly get described pearl guttural tablets, sheet weight 1.95g.
Embodiment 2:
Margarita powder 5000g
Fructus Mume extractum 120g
Radix Glycyrrhizae extractum powder 400g
Mentholum 100g
Mentholum 10g
Sorbitol 6085g
Malic acid 250g
Sweetleaf centautin 2g
Magnesium stearate 43g
Ethanol 20mL
Make 10000.
Preparation:
(1) at first respectively Margarita powder is taken by weighing 5000 grams, Radix Glycyrrhizae extractum powder 400 grams, sweetleaf centautin 2 gram mix homogeneously, add Fructus Mume extractum 120 again and restrained 18 mesh sieve system soft materials.Again the wet granular that obtains 60 ℃ of dryings two hours, after 20 order granulate, it is standby to obtain dried granule;
(2) again Mentholum 100 is restrained in the ethanol that is dissolved into 20 milliliters, this solution is being sprayed onto on the dried granule of above-mentioned preparation airing under the room temperature;
(3) tabletting behind step (2) gained granule and sorbitol 6085 grams, magnesium stearate 43 grams, the malic acid 250 gram mix homogeneously promptly get described pearl guttural tablets, sheet weight 1.2g.
Embodiment 3:
Margarita powder 1000g
Fructus Mume extractum 120g
Radix Glycyrrhizae extractum powder 400g
Mentholum 100g
Mentholum 100g
Sorbitol 6085g
Malic acid 250g
Sweetleaf centautin 2g
Magnesium stearate 43g
Ethanol 20mL
Make 5000.
Preparation:
(1) at first respectively Margarita powder is taken by weighing 1000 grams, Radix Glycyrrhizae extractum powder 400 grams, sweetleaf centautin 2 gram mix homogeneously, add Fructus Mume extractum 120 again and restrained 18 mesh sieve system soft materials.Again the wet granular that obtains 60 ℃ of dryings two hours, after 20 order granulate, it is standby to obtain dried granule;
(2) again Mentholum 100 is restrained in the ethanol that is dissolved into 20 milliliters, this solution is being sprayed onto on the dried granule of above-mentioned preparation airing under the room temperature;
(3) tabletting behind step (2) gained granule and sorbitol 6085 grams, magnesium stearate 43 grams, the malic acid 250 gram mix homogeneously promptly get described pearl guttural tablets, sheet weight 1.6g.
Embodiment 4:
Prescription:
Margarita powder 1000g
Fructus Mume extractum 100g
Radix Glycyrrhizae extractum powder 100g
Mentholum 15g
Sorbitol 150g
Malic acid 100g
Sweetleaf centautin 0.1g
Magnesium stearate 10g
Ethanol 20mL
Make 1000.
Preparation:
(1) at first respectively Margarita powder is taken by weighing 1000 grams, Radix Glycyrrhizae extractum powder 100 grams, sweetleaf centautin 0.1 gram mix homogeneously, add Fructus Mume extractum 100 again and restrained 18 mesh sieve system soft materials.Again the wet granular that obtains 60 ℃ of dryings two hours, after 20 order granulate, it is standby to obtain dried granule;
(2) again Mentholum 15 is restrained in the ethanol that is dissolved into 20 milliliters, this solution is being sprayed onto on the dried granule of above-mentioned preparation airing under the room temperature;
(3) tabletting behind step (2) gained granule and sorbitol 100 grams, magnesium stearate 10 grams, the malic acid 100 gram mix homogeneously promptly get described pearl guttural tablets, sheet weight 1.4g.
Embodiment 5:
Prescription:
Margarita powder 2500g
Fructus Mume extractum 400g
Radix Glycyrrhizae extractum powder 400g
Mentholum 200g
Sorbitol 1000g
Malic acid 500g
Sweetleaf centautin 1.0g
Magnesium stearate 30g
Ethanol 20mL
Make 3000.
Preparation:
(1) at first respectively Margarita powder is taken by weighing 2500 grams, Radix Glycyrrhizae extractum powder 400 grams, wet the closing evenly of sweetleaf centautin 1.0 grams, add Fructus Mume extractum 400 again and restrained 18 mesh sieve system soft materials.Again the wet granular that obtains 60 ℃ of dryings two hours, after 20 order granulate, it is standby to obtain dried granule;
(2) again Mentholum 200 is restrained in the ethanol that is dissolved into 20 milliliters, this solution is being sprayed onto on the dried granule of above-mentioned preparation airing under the room temperature;
(3) tabletting behind step (2) gained granule and sorbitol 1000 grams, magnesium stearate 30 grams, the malic acid 500 gram mix homogeneously promptly get described pearl guttural tablets, sheet weight 1.6g.
Embodiment 6:
Prescription:
Margarita powder 4000g
Fructus Mume extractum 700g
Radix Glycyrrhizae extractum powder 700g
Mentholum 500g
Sorbitol 500g
Malic acid 500g
Sweetleaf centautin 5.0g
Magnesium stearate 30g
Ethanol 20mL
Make 5000.
Preparation:
(1) at first respectively Margarita powder is taken by weighing 4000 grams, Radix Glycyrrhizae extractum powder 700 grams, sweetleaf centautin 5 gram mix homogeneously, add Fructus Mume extractum 700 again and restrained 18 mesh sieve system soft materials.Again the wet granular that obtains 60 ℃ of dryings two hours, after 20 order granulate, it is standby to obtain dried granule;
(2) again Mentholum 500 is restrained in the ethanol that is dissolved into 20 milliliters, this solution is being sprayed onto on the dried granule of above-mentioned preparation airing under the room temperature;
(3) tabletting behind step (2) gained granule and sorbitol 500 grams, magnesium stearate 30 grams, the malic acid 500 gram mix homogeneously promptly get described Margarita moistening and cleaning throat and close sheet, sheet weight 1.3g.
Embodiment 7:
Prescription:
Margarita powder 5000g
Fructus Mume extractum 1000g
Radix Glycyrrhizae extractum powder 1000g
Mentholum 1000g
Sorbitol 7000g
Malic acid 3000g
Sweetleaf centautin 10g
Magnesium stearate 50g
Ethanol 20mL
Make 10000.
Preparation:
(1) at first respectively Margarita powder is taken by weighing 5000 grams, Radix Glycyrrhizae extractum powder 1000 grams, sweetleaf centautin 10 gram mix homogeneously, add Fructus Mume extractum 1000 again and restrained 18 mesh sieve system soft materials.Again the wet granular that obtains 60 ℃ of dryings two hours, after 20 order granulate, it is standby to obtain dried granule;
(2) again Mentholum 1000 is restrained in the ethanol that is dissolved into 20 milliliters, this solution is being sprayed onto on the dried granule of above-mentioned preparation airing under the room temperature;
(3) tabletting behind step (2) gained granule and sorbitol 7000 grams, magnesium stearate 50 grams, the malic acid 3000 gram mix homogeneously promptly get described pearl guttural tablets, sheet weight 1.8g.
Embodiment 8:
Prescription:
Margarita powder 2000g
Fructus Mume extractum 300g
Radix Glycyrrhizae extractum powder 500g
Mentholum 400g
Sorbitol 3000g
Malic acid 1500g
Sweetleaf centautin 5g
Magnesium stearate 25g
Ethanol 20mL
Make 5000.
Preparation:
(1) at first respectively Margarita powder is taken by weighing 2000 grams, Radix Glycyrrhizae extractum powder 500 grams, sweetleaf centautin 5 gram mix homogeneously, add Fructus Mume extractum 300 again and restrained 18 mesh sieve system soft materials.Again the wet granular that obtains 60 ℃ of dryings two hours, after 20 order granulate, it is standby to obtain dried granule;
(2) again Mentholum 400 is restrained in the ethanol that is dissolved into 20 milliliters, this solution is being sprayed onto on the dried granule of above-mentioned preparation airing under the room temperature;
(3) tabletting behind step (2) gained granule and sorbitol 3000 grams, magnesium stearate 25 grams, the malic acid 1500 gram mix homogeneously promptly get described pearl guttural tablets, sheet weight 1.5g.
Embodiment 9: antiinflammatory action
Experiment purpose: the buccal tablet on Carrageenan causes the influence of mice foot swelling
Experimental technique: get 48 of kunming mices, body weight 18～22 grams, male female half and half, body weight is divided into 4 groups at random, be respectively normal saline, the pearl lozenge height, low dose group gives embodiment 1 gained pearl lozenge 5.03 gram/kilograms respectively, 2.57 gram/kilogram, positive controls gives JINSANGZIHOUBAO 3.05 gram/kilograms, the blank group gives 30 milliliters/kilogram of normal saline, equal gastric infusion, every day 1 time, continuous four days, mice foot volume measuring instrument was measured the sufficient volume in a mice left side in the 4th day, was medicine front foot volume normal value, administration then, stand on tiptoe 0.03 milliliter of end intradermal injection 1% carrageenin of foot about 1 hour behind the medicine, measure respectively and cause scorching back 1,3,5,7 and 24 hours left sufficient volume calculates the volume of the left back foot swelling of mice, calculates the left back foot swelling percentage rate of mice.Initial data sees Table 1, and statistical result sees Table 2:
Table 1: each organizes mice in the foot swelling rate data to scorching back different time
Table 2: cause the statistical result of scorching back different time foot swelling rate (x ± s, %)
| Group | Dosage | Cause scorching back different time foot swelling rate (x ± s, %) |
| (g/kg) | 1h | 3h | 5h | 7h | 24h | |
| Normal saline | 30ml/kg | 42.3±0.3 | 92.6±0.4 | 80.7±0.34 | 71.6±0.26 | 62.6±0.5 |
| High dose | 5.03 | 20.4±0.4** | 41.2±0.6** | 33.7±0.5** | 35.7±0.3** | 28.7±0.3** |
| Low dosage | 2.57 | 31.5±0.3** | 65.7±0.4** | 49.7±0.4** | 44.6±0.5** | 30.7±0.5** |
| Matched group | 3.05 | 21.1±0.5* | 60.5±0.4* | 42.1±0.2* | 35.8±0.3* | 30.6±0.3* |
Annotate: with normal saline than * P＜0.05 * * P＜0.01 number of animals n=10
Conclusion: the result shows the inflammatory swelling that the pearl lozenge high and low dose all has tangible anti-carrageenin to cause, and effect is better than JINSANGZIHOUBAO.
Embodiment 10: the promoting the production of body fluid for nourishing the lung effect
Experiment purpose: the Margarita powder buccal tablet is to the influence of the phenol red secretory volume of mice
Experimental technique: 48 of the mices of getting body weight 20～22 gram, male and female half and half, be equally divided into 4 groups, high and low dose group oral cavity is respectively smeared embodiment 1 gained Margarita and is closed sheet 5.03 gram/kilograms, 2.57 gram/kilograms, positive controls is JINSANGZIHOUBAO 3.05 gram/kilograms, and the blank group is given the equivalent normal saline.Every day 2 times, successive administration 3 days.Administration was after 30 minutes in the 4th day, lumbar injection 0.355% phenol red, 0.6 milliliter/only, put to death animal after 30 minutes, peel off trachea, wash trachea repeatedly for 2 milliliters with 5% sodium bicarbonate, flushing liquor with ultraviolet in 546nm place colorimetric, on the phenol red standard curve, calculate the phenol red secretory volume of each treated animal, carry out statistical analysis.Experimental data sees Table 3, and statistical result sees Table 4:
Table 3: pearl lozenge is to the experimental data that influences of the phenol red secretory volume of mice
| Phenol red secretory volume (ug/ml) | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| The normal saline group | 1.68 | 1.71 | 1.72 | 1.71 | 1.68 | 1.65 | 1.63 | 1.64 | 1.68 | 1.66 |
| High dose group | 6.23 | 6.15 | 6.17 | 6.28 | 6.25 | 6.54 | 6.42 | 6.34 | 6.08 | 6.21 |
| Low dose group | 5.57 | 5.64 | 5.74 | 5.16 | 5.18 | 5.64 | 5.29 | 5.34 | 5.18 | 5.6 |
| Positive controls | 4.07 | 4.41 | 4.24 | 4.51 | 3.98 | 3.78 | 3.85 | 4.54 | 4.35 | 4.33 |
Table 4: pearl lozenge is to the statistical result that influences of the phenol red secretory volume of mice
| Group | Dosage (g/kg) | Phenol red secretory volume (ug/ml) |
| Normal saline | 0.2ml | 1.67±0.03** |
| Pearl lozenge (height) | 5.03 | 6.27±0.13** |
| Pearl lozenge (low) | 2.57 | 5.43±0.21** |
| JINSANGZIHOUBAO | 3.05 | 4.21±0.26* |
Annotate: with normal saline than * P＜0.05 * * P＜0.01 number of animals n=10
Experimental result: the result shows that Margarita powder buccal tablet high and low dose all has tangible promoting the production of body fluid for nourishing the lung effect, and effect is better than JINSANGZIHOUBAO.
Embodiment 11: the function of moistening and cleaning throat of the pearl lozenge of different prescription proportionings relatively
One. antiinflammatory action
1. the different proportional quantities according to Margarita powder divide into groups
2. experimental technique: get 50 of kunming mices, body weight 18～22 grams, male female half and half, body weight is divided into 5 groups at random, be respectively normal saline, Margarita powder content height, in, low, pure content group, Margarita powder content height, in, the low content group gives embodiment 2 respectively, embodiment 1, embodiment 3 gained pearl lozenges 3.01 gram/kilograms, the pure content group of Margarita powder gives pure Margarita powder 3.01 gram/kilograms, the blank group gives 30 milliliters/kilogram of normal saline, equal gastric infusion, every day 1 time, continuous four days, mice foot volume measuring instrument was measured the sufficient volume in a mice left side in the 4th day, be medicine front foot volume normal value, administration then, stand on tiptoe 0.03 milliliter of end intradermal injection 1% carrageenin of foot about 1 hour is measured respectively and is caused scorching back 1 behind the medicine, 3,5,7 and 24 hours left sufficient volume, calculate the volume of the left back foot swelling of mice, calculate the left back foot swelling percentage rate of mice.Experimental data sees Table 5, and statistical result the results are shown in Table 6:
Table 5: the different content on Carrageenan causes the experimental data that influences of mice foot swelling
Table 6: the different content on Carrageenan causes the statistical result that influences of mice foot swelling
Annotate: with normal saline than * P＜0.05 * * P＜0.01 number of animals n=10
2. conclusion: the result shows that the content group is more effective than the inflammatory swelling effect that other group antagonism carrageenin cause in the Margarita powder.
Two. the promoting the production of body fluid for nourishing the lung effect
1. the different proportional quantities according to Margarita powder divide into groups
| Low content group (embodiment 3) | 1000 grams | 120 grams | 400 grams |
2. experimental technique: 50 of the mices of getting body weight 20～22 grams, male and female half and half, be equally divided into 5 groups, high, medium and low Margarita powder content group oral cavity is respectively smeared embodiment 2, embodiment 1, embodiment 3 gained pearl lozenges 3.01 gram/kilograms, pure Margarita powder 3.01 gram/kilograms are smeared in pure Margarita powder group oral cavity, and the blank group is given the equivalent normal saline.Every day 2 times, successive administration 3 days.Administration was after 30 minutes in the 4th day, lumbar injection 0.355% phenol red, 0.6 milliliter/only, put to death animal after 30 minutes, peel off trachea, wash trachea repeatedly for 2 milliliters with 5% sodium bicarbonate, flushing liquor with ultraviolet in 546nm place colorimetric, on the phenol red standard curve, calculate the phenol red secretory volume of each treated animal, carry out statistical analysis.Experimental data sees Table 7, and statistical result the results are shown in Table 8:
Table 7: the Margarita powder buccal tablet is to the experimental data that influences of the phenol red secretory volume of mice
| Phenol red secretory volume (ug/ml) | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| The normal saline group | 1.71 | 1.75 | 1.74 | 1.69 | 1.74 | 1.75 | 1.68 | 1.72 | 1.66 | 1.71 |
| The high-load group | 5.34 | 5.52 | 5.13 | 5.57 | 5.46 | 5.48 | 5.13 | 5.12 | 5.74 | 5.34 |
| Middle content group | 6.47 | 6.54 | 6.23 | 6.54 | 6.58 | 6.32 | 6.15 | 6.87 | 6.5 | 6.47 |
| The low content group | 5.52 | 5.56 | 5.6 | 5.26 | 5.48 | 5.87 | 5.68 | 5.34 | 5.12 | 5.52 |
| Pure Margarita powder group | 3.26 | 3.34 | 3.54 | 3.13 | 3.18 | 3.31 | 3.54 | 3.64 | 3.54 | 3.26 |
Table 8: pearl lozenge is to the statistical result that influences of the phenol red secretory volume of mice
| Group | Dosage (g/kg) | Phenol red secretory volume (ug/ml) |
| The normal saline group | 0.2ml | 1.72±0.03 |
| Group | Dosage (g/kg) | Phenol red secretory volume (ug/ml) |
| The high-load group | 3.01 | 5.39±0.21** |
| Middle content group | 3.01 | 6.47±0.20** |
| The low content group | 3.01 | 5.49±0.22* |
| Pure Margarita powder group | 3.01 | 3.39±0.17* |
Annotate: with normal saline than * P＜0.05 * * P＜0.01 number of animals n=10
3. conclusion: the result shows that the content group is more obvious than the promoting the production of body fluid for nourishing the lung effect of other groups in the Margarita powder.
Embodiment 11: the guttural tablets stability test
Experiment purpose: gained guttural tablets of the present invention and traditional pearl lozenge are compared investigation, comprising: the influence factor who is subjected to illumination, high temperature, high humility and air at room temperature.Come the variation of two kinds of buccal tablets of comparison on minute (falling) hydrolysis products, content, melting.
The preparation of tradition pearl lozenge is specially: Margarita powder 800g crosses 200 mesh sieves, and starch 1200g, sucrose 400g cross 14 mesh sieves, mixing, the wet grain of spray 20mL ethanol system, 60 ℃ of forced air dryings are excessively behind the 18 mesh sieve granulate, add magnesium stearate 43g, micropowder silica gel 40g mix homogeneously, tabletting is made 1000.
1) illumination experiment
Get embodiment 1 gained pearl lozenge and place plate respectively, under the 3500lx illuminance, place, and in the 1st, 3, each index is measured in sampling in 5,10 days, compares with the contrast buccal tablet.The result as shown in table 11 (in the table in the group column 1 for the contrast buccal tablet, 2 is the embodiment of the invention 1 gained buccal tablet):
Table 11: illumination experimental result
Experimental result shows: gained buccal tablet of the present invention was through 3500lx illumination 10 days, and every index does not obviously change, but it is more obvious than the present invention buccal tablet to contrast buccal tablet buccal tablet weightlessness in 5 days and 10 days.
2) high temperature experiment
Get embodiment 1 gained buccal tablet and contrast in the buccal tablet horizontalization ware, under 40 ℃, 60 ℃, 80 ℃ conditions, prevent respectively, and investigate, measure every index, compare in the 1st, 3,5,10 samplings.The result is shown in table 12～14: (1 is the contrast buccal tablet in the group project, and 2 are buccal tablet of the present invention)
Show 12:40 ℃ of high temperature experimental result
| Time (my god) | Group | Color and luster | Melting | Increase weightless % | Catabolite % | Labelled amount % |
Show 13:60 ℃ of high temperature experimental result
Show 14:80 ℃ of high temperature experimental result
Experimental result shows: when 40 ℃, 60 ℃, 80 ℃ high temperature were placed 10 days, except that air slaking weightlessness was arranged, all the other every indexs did not obviously change.But from weightless project, the weightlessness of contrast buccal tablet is obviously serious than the present invention buccal tablet, so that gained of the present invention closes sheet is more suitable high temperature resistant.
3) the high humility experiment is got embodiment 1 gained buccal tablet and is contrasted buccal tablet and places plate, is to place 10 days under 95% and 70% condition and investigate in sampling in the 1st, 3,5,10 day at relative humidity respectively, measures every index, compares.The result is shown in table 15,16:
Table 15: the experimental result of relative humidity 95%
Table 16: the experimental result of relative humidity 70%
Experimental result shows: at relative humidity is to place 10 days under 95% and 70% condition, and the moisture absorption of contrast buccal tablet is obvious, and gained buccal tablet of the present invention is difficult for moisture absorption, and moistureproof ability is obviously better.Catabolite item buccal tablet result of the present invention also obviously is better than contrasting buccal tablet.
Claims (3)
1. pearl guttural tablets is characterized in that preparing that described to contain tablet raw material composed as follows:
Margarita powder 1000～5000g
Fructus Mume extractum 100～1000g
Radix Glycyrrhizae extractum powder 100～2000g
Mentholum 100～1000g
Sorbitol 100～7000g
Malic acid 100～3000g
Sweetleaf centautin 0.1～10g
Magnesium stearate 10～50g
Ethanol 20mL;
Described Fructus Mume extractum is made by following method: Fructus Mume water is carried or alcohol extraction 2～3 times, it is 1.2～1.4kg/L that merge extractive liquid, is concentrated into proportion, promptly gets described Fructus Mume extractum.
2. pearl guttural tablets as claimed in claim 1, it is composed as follows to it is characterized in that preparing per 10000 raw material of described buccal tablet:
Margarita powder 1000～5000g
Fructus Mume extractum 100～1000g
Radix Glycyrrhizae extractum powder 100～2000g
Mentholum 100～1000g
Sorbitol 100～7000g
Malic acid 100～3000g
Sweetleaf centautin 0.1～10g
Magnesium stearate 10～50g
Ethanol 20mL.
3. pearl guttural tablets as claimed in claim 2, it is composed as follows to it is characterized in that preparing per 10000 raw material of described buccal tablet:
Margarita powder 3000g
Fructus Mume extractum 120g
Radix Glycyrrhizae extractum powder 400g
Mentholum 100g
Sorbitol 6085g
Malic acid 250g
Sweetleaf centautin 2g
Magnesium stearate 43g
Ethanol 20mL.
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