CN1839938A - Traditional Chinese cinnamomum cassia extract superfine powder preparation method - Google Patents
Traditional Chinese cinnamomum cassia extract superfine powder preparation method Download PDFInfo
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- CN1839938A CN1839938A CN 200610023278 CN200610023278A CN1839938A CN 1839938 A CN1839938 A CN 1839938A CN 200610023278 CN200610023278 CN 200610023278 CN 200610023278 A CN200610023278 A CN 200610023278A CN 1839938 A CN1839938 A CN 1839938A
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Abstract
The invention relates to a process for preparing superfine powder of Chinese herbal Cinnamomum cassia extract having alpha- glucosidase inhibiting activity, which comprises obtaining effective portion with strong inhibiting activity to alpha-glucosidase from Cinnamomum cassia by means of fluid extraction technique, then formulating ethanol solution of the Cinnamomum cassia extract, carrying out granulation to the extract by employing hypercritical fluid CO2 anti-solvent depositing device. The superfine powder of the extract has good dispersity in water, thus the bioavailability of the medicament can be improved.
Description
Technical field
The present invention relates to a kind of preparation method with superfines of the active Chinese medicine cinnamon extract of alpha-glucosidase inhibitor, belonging to Chinese herbal medicine preparation and chemistry has worker's technical field.
Background technology
The granule granular of Chinese herbal medicine generally adopts machining process such as comminution by gas stream and grinding.Chinese herbal medicine can be improved the therapeutical effect of medicine by particulate size of control or particle diameter; Particularly the relatively poor Chinese medicine of some water solublity by the granular of Chinese medicinal granule, can improve the dispersibility in water, can improve the effect that its drug effect and performance smelting are treated.
Supercritical fluid anti-solvent precipitating technology is that a kind of change by solvent phase realizes that solute separates out the technology that forms ultrafine dust from system, and aspect the Chinese medicine granular, particularly Chinese medicine cinnamon extract granular aspect yet there are no report.
Supercritical fluid anti-solvent precipitating technology is as strippant with supercritical fluid.Solute and solvent dissolve each other generally speaking, and the dissolubility in the strippant supercritical fluid is very little, when supercritical fluid is dissolved in the solution, the diluted expansion of solution, reduced the solvability of former solvent to solute, form bigger hypersaturated state at short notice, and solute is separated out, form purity height, the uniform fine particle of particle size distribution.Super-critical anti-solvent precipitating technology is applicable to separation, purification and the granular etc. of indissoluble in some supercritical fluid or insoluble matter.
Summary of the invention
The objective of the invention is to utilize supercritical fluid anti-solvent precipitating technology to prepare the method for Chinese medicine cinnamon extract superfine powder.
The main points of the inventive method are: at first adopt the supercritical fluid extraction of Chinese medicine cinnamon and prepare Cortex Cinnamomi extract (patent application is arranged in addition) with the process integration of ethanol extraction, then Cortex Cinnamomi extract is utilized supercritical fluid anti-solvent precipitating technology to prepare the Chinese medicine cinnamon extract superfine powder.
The preparation method of a kind of Chinese medicine cinnamon extract superfine powder of the present invention is characterized in that having following preparation process and step:
A. Chinese medicine cinnamon is put into supercritical CO after pulverizing, sieving
2In the fluid extraction device, pass through supercritical CO
2Fluid extracts, remove the active low-polarity constituents of alpha-glucosidase unrestraint, its raffinate carries out liquid-solid extraction with the solvent dehydrated alcohol, then alcohol extraction liquid is evaporated in rotary evaporator and reclaim ethanol, make the effective site that alpha-glucosidase is had strong inhibitory activity, this effective site is the Chinese medicine cinnamon extract;
B. above-mentioned Chinese medicine cinnamon extract is mixed with the certain density alcoholic solution of 5～10g/L, with supercritical fluid CO
2In the importing expanding chamber, CO
2Flow be 350～450g per hour, the pressure of expanding chamber is controlled at 10～20MPa, temperature is controlled at 20～40 ℃; The alcoholic solution of Cortex Cinnamomi extract is pumped into expanding chamber with the flow velocity of 1～2ml/min by nozzle; At supercritical CO
2Separate out the superfines of extract under the anti-solvent action of fluid in the expanding chamber, its particle diameter is 0.4～0.9 μ m.
Principle of the present invention is: with supercritical fluid CO
2Be strippant, Cortex Cinnamomi extract and ethanol dissolve each other, and at supercritical fluid CO
2In dissolubility very little, work as CO
2When being dissolved in the alcoholic solution, solution dilution expands, and has reduced the solvability of former etoh solvent to Cortex Cinnamomi extract, reaches bigger hypersaturated state at short notice, and forms purity height, the uniform fine particle of particle size distribution.
With the Cortex Cinnamomi extract powder that supercritical fluid anti-solvent precipitating granular technology makes, its favorable dispersibility in water; It is suitable for the insoluble medicine production of some water, to improve bioavailability of medicament.
The inventive method preparation condition gentleness can keep the inhibition activity of Cortex Cinnamomi extract to alpha-glucosidase.
The specific embodiment
After now embodiments of the invention being described in.
Embodiment 1
Cortex Cinnamomi extract preparation process and step in the present embodiment are as follows:
(1) uses supercritical CO
2The fluid extraction device prepares the Chinese medicine cinnamon extract: put into supercritical CO after Chinese medicine cinnamon is pulverized, sieved
2Extract in the fluid extraction device, from Chinese medicine cinnamon, remove the active low-polarity constituents of alpha-glucosidase unrestraint, its raffinate carries out liquid-solid extraction with dehydrated alcohol, then alcohol extraction liquid is evaporated in rotary evaporator and reclaim ethanol, make the effective site that alpha-glucosidase is had strong inhibitory activity; This effective site is the Chinese medicine cinnamon extract.(this part detailed content referring to another of patent application case same period.)
(2) use supercritical fluid CO
2Anti-solvent precipitation device prepares the Chinese medicine cinnamon extract superfine powder: above-mentioned Chinese medicine cinnamon extract is mixed with the alcoholic solution of 5g/L concentration, uses supercritical fluid CO
2(this installs by CO anti-solvent precipitation device
2Compositions such as storage tank, refrigerator, pump, nozzle, expanding chamber, separated from solvent jar carry out the granule granular of extract; With supercritical fluid CO
2In the importing expanding chamber, CO
2Flow be 400g per hour, the pressure of expanding chamber is controlled at 10MPa, temperature is controlled at 20 ℃; The alcoholic solution of the Cortex Cinnamomi extract flow velocity with 1ml/min is pumped in the expanding chamber by nozzle; At supercritical CO
2Separate out the superfines of extract under the anti-solvent action of fluid, its particle diameter is 0.4～0.7 μ m.
Embodiment 2
The Cortex Cinnamomi extract preparation process and the step of present embodiment and the foregoing description 1 are identical.Different is: Chinese medicine extract is mixed with the alcoholic solution of 10g/L concentration; The alcoholic solution of Cortex Cinnamomi extract pumps into expanding chamber with the flow velocity of 2ml/min by nozzle; CO
2Flow be 450g per hour, the pressure of expanding chamber is controlled at 20MPa, temperature is controlled at 40 ℃; The particle diameter of finally separating out extract superfine powder is 0.6～0.9 μ m.
The particle diameter of the extract powder that makes in present embodiment microgranule in 5600 times of observed microphotograpies of Hirox 3 D video microscope is 0.4～0.9 μ m.
Claims (1)
1. the preparation method of a Chinese medicine cinnamon extract superfine powder is characterized in that having following preparation process and step:
A. put into supercritical CO after Chinese medicine cinnamon being pulverized, sieved
2In the fluid extraction device, pass through supercritical CO
2Fluid extracts, remove the active low-polarity constituents of alpha-glucosidase unrestraint, its raffinate carries out liquid-solid extraction with the solvent dehydrated alcohol, then alcohol extraction liquid is evaporated in rotary evaporator and reclaim ethanol, make the effective site that alpha-glucosidase is had strong inhibitory activity, this effective site is the Chinese medicine cinnamon extract;
B. above-mentioned Chinese medicine cinnamon extract is mixed with the certain density alcoholic solution of 5～10g/L, with supercritical fluid CO
2In the importing expanding chamber, CO
2Flow be 350～450g per hour, the pressure of expanding chamber is controlled at 10～20MPa, temperature is controlled at 20～40 ℃; The alcoholic solution of Cortex Cinnamomi extract is pumped into expanding chamber with the flow velocity of 1～2ml/min by nozzle; At supercritical CO
2Separate out the superfines of extract under the anti-solvent action of fluid in the expanding chamber, its particle diameter is 0.4～0.9 μ m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610023278 CN1839938A (en) | 2006-01-12 | 2006-01-12 | Traditional Chinese cinnamomum cassia extract superfine powder preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610023278 CN1839938A (en) | 2006-01-12 | 2006-01-12 | Traditional Chinese cinnamomum cassia extract superfine powder preparation method |
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| CN1839938A true CN1839938A (en) | 2006-10-04 |
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| CN 200610023278 Pending CN1839938A (en) | 2006-01-12 | 2006-01-12 | Traditional Chinese cinnamomum cassia extract superfine powder preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530469B (en) * | 2009-04-20 | 2011-10-05 | 孙益民 | Method for preparing effective component group of water soluble Chinese cassia tree |
| CN103221059A (en) * | 2010-11-23 | 2013-07-24 | 地塞医药有限公司 | Substantially coumarin-free extract of cinnamon and its production method |
| CN105361183A (en) * | 2015-11-06 | 2016-03-02 | 孟令刚 | Process for preparing maca particle powder |
| CN106975076A (en) * | 2017-04-14 | 2017-07-25 | 青岛市第三人民医院 | A kind of pepsin coating tablet containing Chinese medical extract |
-
2006
- 2006-01-12 CN CN 200610023278 patent/CN1839938A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530469B (en) * | 2009-04-20 | 2011-10-05 | 孙益民 | Method for preparing effective component group of water soluble Chinese cassia tree |
| CN103221059A (en) * | 2010-11-23 | 2013-07-24 | 地塞医药有限公司 | Substantially coumarin-free extract of cinnamon and its production method |
| CN105361183A (en) * | 2015-11-06 | 2016-03-02 | 孟令刚 | Process for preparing maca particle powder |
| CN106975076A (en) * | 2017-04-14 | 2017-07-25 | 青岛市第三人民医院 | A kind of pepsin coating tablet containing Chinese medical extract |
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