CN1830492B - Bioprotein artificial meninges sheet - Google Patents
Bioprotein artificial meninges sheet Download PDFInfo
- Publication number
- CN1830492B CN1830492B CN2006100652104A CN200610065210A CN1830492B CN 1830492 B CN1830492 B CN 1830492B CN 2006100652104 A CN2006100652104 A CN 2006100652104A CN 200610065210 A CN200610065210 A CN 200610065210A CN 1830492 B CN1830492 B CN 1830492B
- Authority
- CN
- China
- Prior art keywords
- meninges
- bioprotein
- sheet
- gel sheet
- implantable medical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000002418 meninge Anatomy 0.000 title claims abstract description 39
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000000741 silica gel Substances 0.000 claims abstract description 44
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 44
- 229960001866 silicon dioxide Drugs 0.000 claims description 42
- 210000001951 dura mater Anatomy 0.000 claims description 28
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 8
- 229910052753 mercury Inorganic materials 0.000 claims description 8
- 210000004556 brain Anatomy 0.000 claims description 7
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 2
- 238000010276 construction Methods 0.000 claims description 2
- 230000002490 cerebral effect Effects 0.000 abstract description 11
- 239000000463 material Substances 0.000 abstract description 8
- 210000005013 brain tissue Anatomy 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 15
- 238000001356 surgical procedure Methods 0.000 description 8
- 102000008186 Collagen Human genes 0.000 description 6
- 108010035532 Collagen Proteins 0.000 description 6
- 230000007547 defect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 210000004761 scalp Anatomy 0.000 description 3
- 239000012467 final product Substances 0.000 description 2
- 238000007917 intracranial administration Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 208000002403 Encephalocele Diseases 0.000 description 1
- 206010016228 Fasciitis Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000001202 rhombencephalon Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
An artificial meninges sheet used as the repairing material of cerebral operation is composed of an implantable medical silica gel sheet whose thickness is not greater than 1 mm, and two artificial hard meninges which are made of bioprotein and attached to both surfaces of said medical silica gel sheet. It has no irritation to brain tissue and rejection reaction.
Description
Technical field
The present invention relates to a kind of medical surgery, especially the patching material of department of cerebral surgery is a kind of bioprotein artificial meninges sheet.
Background technology
Geneogenous defect of meninges, or the defect of meninges that is caused because of wound and neurosurgery postoperative can cause the serious phenomenon of leakage, thereby jeopardize human life.This just needs shutoff, and it is damaged or/and leak.At present, the Clinical Processing mode is mainly the direct damaged place of stitching of using artificial dura mater patching material and using artificial dura mater patching material directly pastes two kinds of forms at damaged place, that can sew up and paste 2 kinds of formulas, corresponding patching material be divided into can sew up and paste two kinds of artificial dura mater patching materials of formula.This dual mode and used patching material all have shortcoming separately.The former is stitched together self meninges, so only be fit to little leak, presses the patient of cerebral hernia decompression hindbrain bulging for acute high cranium, the sew application difficulty, and when sewing up, injure cerebral tissue easily.It is synthetic by bioprotein pasting the artificial meninges of using at damaged place, is pure bioprotein film, though have that pliable and tough shape is good, good springiness and an advantage such as absorption easily; Yet at clinicing aspect, when using this bioprotein film to carry out the defect of meninges reparation, on the one hand, existence pastes not tight, forms the outer hydrops of meninges; On the other hand, owing to can absorb, when making skull repairing in the later stage, artificial meninges is absorbed and lacks protection to meninges, is easy to accidentally injure cerebral tissue, and cerebrospinal fluid spills, and forms the postoperative hypohydrops.Therefore, ideal artificial meninges should be to meet following condition: 1, have reliable intensity and good pliability, elasticity; Can bear certain power when surgical repair and after repairing and produce distortion and not damaged.2, has good biological tissue's compatibility, no foreign body rejection.3, can not be absorbed fully; Can play the effect of protection cerebral tissue, can play a part again to isolate scalp soft tissue and cerebral tissue well, make later cranioplasty surgery safer, reliable.At present, the artificial meninges of Shi Yonging is simple bioprotein clinically, as collagen protein artificial dura mater etc., can be absorbed fully, is unfavorable for post surgery treatment.Also do not possess the preferable artificial meninges that the artificial meninges defect repairing of above-mentioned three conditions is used simultaneously.Disclosed technical data also is the bioprotein meninges that simple material is made in the relevant patent documentation, be to disclose a kind of absorbability artificial dura mater in the Chinese patent literature of CN1155347C as notification number, though be double-decker, but its composition is absorbability, has above-mentioned defective in use equally.
Summary of the invention
The present invention be mainly solve existing when clinically defect of meninges being repaired used artificial meninges be absorbed easily, can't play abundant isolation scalp soft tissue and cerebral tissue effect and be unfavorable for problems such as cranioplasty surgery afterwards, and a kind of bioprotein artificial meninges sheet that not exclusively is absorbed and has good pliability, elasticity and biological tissue's compatibility is provided.
Bioprotein artificial meninges sheet of the present invention, include implantable medical silica-gel sheet and bioprotein artificial dura mater, the thickness of described implantable medical silica-gel sheet is not more than 1mm, plasticity deformation pressure takes place be not more than 20 millimetress of mercury, its deformation ratio minimum is 30%, and tensile strength is no less than 50 millimetress of mercury; The two sides of described implantable medical silica-gel sheet is the bioprotein artificial dura mater, and the above and below that forms implantable medical silica-gel sheet all has the composite construction of bioprotein artificial dura mater.
Have equally distributed through hole on the above-mentioned implantable medical silica-gel sheet, its adjacent holes is apart from being not more than 2 centimetres, and its aperture is 2～3 millimeters.
Be distributed with pit on the above-mentioned implantable medical silica-gel sheet surface, the depth capacity of its pit is less than 0.3 millimeter, and this pit is of a size of 2～3 millimeters.
Above-mentioned implantable medical silica-gel sheet and the contacted surface of bioprotein artificial dura mater stick into one by sending biological fibrin glue forth.
The diaphragm-operated thickness of brain of the present invention is not more than 3 millimeters, preferred 2.4 millimeters.
Above-mentioned silica gel sheet and bioprotein artificial dura mater are existing medical material, or are fit to the artificial meninges of bioprotein of human body through the prepared energy of common processes by prior art.As: get the tendon of animal, adopt biochemical the separation, extractive technique, the preparation biological collagen also forms membranaceous getting final product.
This meninges sheet is when carrying out the defect of meninges repairing, because its bioprotein artificial dura mater is absorbed by tissue easily, the repairing of favourable meninges, and medical silica-gel sheet wherein is difficult for absorbing, cranioplasty surgeries after helping etc., the artificial dura mater of this meninges sheet appearance has avoided the silica gel sheet directly to contact the generation of cerebral tissue and caused tissue stimulation of subcutaneous tissue and rejection.
Hole or select for use and the compact concaveconvex structure of artificial dura mater has distributed on the described medical silica-gel sheet, thereby the artificial dura mater on medical silica-gel sheet two sides is closely sticked together with the medical silica-gel sheet, and the silica gel sheet on two sides is consistent when producing physical change, similar to a monoblock artificial dura mater, has same pliability, elasticity, to alleviate intracranial pressure.This meninges sheet also has following characteristics in addition: 1, the present invention adopts the medical silica-gel sheet to be the bioprotein artificial dura mater outward, making it to have the bioprotein artificial dura mater can absorb, and the medical silica-gel sheet can not absorb double effects, has overcome the shortcoming that can absorb merely and can not absorb artificial meninges.Can directly it be covered on the brain surface when 2, operating, edge reuse bioprotein is gluing stifled, both can avoid leakage, and is simple to operate again.3, this meninges sheet has elasticity, pliability, can be good at alleviating intracranial pressure.4, because medical silica-gel sheet two sides is the bioprotein layer, and histocompatibility is good, can absorb, and merge, form pseudomembrane, avoid the silica gel sheet directly to contact cerebral tissue and caused tissue stimulation of subcutaneous tissue and rejection with when injected organism tissue.5, owing on the silica gel sheet a lot of apertures is arranged, and distribute rationally, the bioprotein artificial dura mater on silica gel sheet two sides is merged, play the effect of reinforcing the silica gel sheet.When 6, carrying out cranioplasty surgery later on, the silica gel sheet plays the boundary effect, can be easy to separate scalp along silica gel sheet outside, is unlikely to hurt cerebral tissue.7, because the silica gel sheet does not absorb,, can be easy to take off the silica gel sheet simultaneously, help post surgery treatment with when injected organism tissue also adhesion.
The alternative cerebral dura mater of this meninges sheet and other body biomembranes can be widely used in the repairing that brain, the heart, gastrointestinal, aponeurosis (aponeuroses), bladder and other have the damaged and hollow organ wall of biomembrane.
The drawing explanation
Accompanying drawing is a structural representation of the present invention.
The specific embodiment
Embodiment 1, selects present hospital implantable medical silica-gel sheet commonly used for use.This silica gel sheet physicochemical property in 0～50 degree temperature range is stable; The human body zest is little, and histocompatibility is good, meets human body implant related standards.The DuraMax collagen protein artificial dura mater of selecting for use the Beijing TianXinFu Medical Treatment equipment Co., Ltd to produce.This collagen protein artificial dura mater has absorbability, and no rejection has characteristics such as good flexibility and attenuation after meeting water, and need not to sew up during operation.But the retrospective deformation pressure of this silica gel sheet is 20 millimetress of mercury; Its deformation ratio is 30%; Tensile strength is 50 millimetress of mercury; Thickness is 0.8 millimeter.
In conjunction with referring to accompanying drawing.On selected silica gel sheet 1, evenly get through hole 3 by 1 * 1 centimetre of square formation with punch device, its aperture is 2～3 millimeters, use two block-shaped identically then, the collagen protein artificial dura mater 2 that area is not less than this silica gel sheet directly is bonded at the two sides of this silica gel sheet 1, gets final product through shearing packing again.
Embodiment 2, and selected implantable medical silica-gel sheet and the characteristic of collagen protein artificial dura mater are with embodiment 1.The plasticity deformation pressure of this silica gel sheet is 15 millimetress of mercury; Its deformation ratio is 35%; Tensile strength is 60 millimetress of mercury; Thickness is 1 millimeter.
Extrude pit with pressing equipment on its two sides on selected silica gel sheet, pit depth is less than 0.3 millimeter, and its size (planar dimension at place, pit top) is 2～3 millimeters; Send biological fibrin glue forth at implantable medical silica-gel sheet and the contacted surface of bioprotein artificial dura mater then, it is sticked together be integral again and can shear packing.
Claims (8)
1. bioprotein artificial meninges sheet, include implantable medical silica-gel sheet and bioprotein artificial dura mater, the thickness that it is characterized in that described implantable medical silica-gel sheet is not more than 1mm, plasticity deformation pressure takes place be not more than 20 millimetress of mercury, deformation ratio is greater than 30%, and tensile strength is no less than 50 millimetress of mercury; The two sides of described implantable medical silica-gel sheet is the bioprotein artificial dura mater, and the above and below that forms implantable medical silica-gel sheet all has the composite construction of bioprotein artificial dura mater.
2. meninges sheet according to claim 1 is characterized in that: have equally distributed through hole on the above-mentioned implantable medical silica-gel sheet, its adjacent holes is apart from being not more than 2 centimetres, and its aperture is 2～3 millimeters.
3. meninges sheet according to claim 1 is characterized in that: be distributed with pit on the above-mentioned implantable medical silica-gel sheet surface, the depth capacity of its pit is less than 0.3 millimeter.
4. according to claim 1 or 2 or 3 described meninges sheets, it is characterized in that: stick into one by sending biological fibrin glue forth on described implantable medical silica-gel sheet and the contacted surface of bioprotein artificial dura mater.
5. according to claim 1 or 2 or 3 described meninges sheets, it is characterized in that: the diaphragm-operated thickness of this brain is not more than 3 millimeters.
6. meninges sheet according to claim 4 is characterized in that: the diaphragm-operated thickness of this brain is not more than 3 millimeters.
7. meninges sheet according to claim 5 is characterized in that: the diaphragm-operated thickness of this brain is not more than 2.4 millimeters.
8. meninges sheet according to claim 6 is characterized in that: the diaphragm-operated thickness of this brain is not more than 2.4 millimeters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100652104A CN1830492B (en) | 2006-03-20 | 2006-03-20 | Bioprotein artificial meninges sheet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100652104A CN1830492B (en) | 2006-03-20 | 2006-03-20 | Bioprotein artificial meninges sheet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1830492A CN1830492A (en) | 2006-09-13 |
| CN1830492B true CN1830492B (en) | 2011-05-18 |
Family
ID=36993092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006100652104A Expired - Fee Related CN1830492B (en) | 2006-03-20 | 2006-03-20 | Bioprotein artificial meninges sheet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1830492B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755205A (en) * | 2012-08-13 | 2012-10-31 | 朱成 | Plaster for craniotomy |
| AT515384B1 (en) * | 2014-02-05 | 2016-04-15 | Dietmar Dr Sonnleitner | Preconnected multilayer film for covering a bone defect site |
| CN106110408A (en) * | 2016-06-21 | 2016-11-16 | 天津市第四中心医院 | The new application of silica gel |
| CN111359018B (en) * | 2020-05-06 | 2023-11-14 | 北京潞康科技有限公司 | Double-layer anti-seepage dura mater repairing sheet and preparation method thereof |
| CN112972060B (en) * | 2021-02-04 | 2023-07-14 | 华东医院 | Device for preventing operation area from blocking after craniotomy in neurosurgery |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030409A1 (en) * | 1999-10-25 | 2001-05-03 | Ghimas S.P.A. | Invasive medical device, especially for guided tissue regeneration |
| CN1317297A (en) * | 2000-04-11 | 2001-10-17 | 张保军 | Absorbable artificial dura meter of brain and its preparing process |
| CN2461505Y (en) * | 2000-12-28 | 2001-11-28 | 郭岩 | Biological artificial hard mater |
| CN2608014Y (en) * | 2003-03-05 | 2004-03-31 | 刘恩重 | Ar-tificial endocranium having both functions of dura mater and arachnoid |
-
2006
- 2006-03-20 CN CN2006100652104A patent/CN1830492B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030409A1 (en) * | 1999-10-25 | 2001-05-03 | Ghimas S.P.A. | Invasive medical device, especially for guided tissue regeneration |
| CN1317297A (en) * | 2000-04-11 | 2001-10-17 | 张保军 | Absorbable artificial dura meter of brain and its preparing process |
| CN2461505Y (en) * | 2000-12-28 | 2001-11-28 | 郭岩 | Biological artificial hard mater |
| CN2608014Y (en) * | 2003-03-05 | 2004-03-31 | 刘恩重 | Ar-tificial endocranium having both functions of dura mater and arachnoid |
Non-Patent Citations (1)
| Title |
|---|
| 张世明等.硬脑膜修复材料的应用研究现状与展望.《中华神经外科杂志》.2003,第19卷(第5期),402-404. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1830492A (en) | 2006-09-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1830492B (en) | Bioprotein artificial meninges sheet | |
| ES2402238T3 (en) | Targeted tissue growth using reduced pressure | |
| AU2009289479B2 (en) | Process for generating microwalled encapsulation balloons | |
| AU2010276271B2 (en) | Particulate tissue graft with components of differing density and methods of making and using the same | |
| CN104349799B (en) | Implant | |
| CN201814903U (en) | Surgical anti-adhesion membrane | |
| CN101370446A (en) | Methods of producing PVA hydrogel implants and related devices | |
| CN107847326B (en) | Orthopedic implants | |
| CN203220462U (en) | Perforated biological patch | |
| DE112017000675T5 (en) | Method of making devices for placing and releasing a temporary implant in the body | |
| CN109876184A (en) | A kind of elasticity can deformation skull-base defects recovery support and preparation method thereof | |
| CN202682096U (en) | Absorbable endocranium repair patch | |
| ES2378189T3 (en) | Flat implant | |
| CN102908676A (en) | Hollowed PP/PVDF (Polypropylene/Polyvinylidene Fluoride) composite hernia sticking patch and preparation method thereof | |
| CA2654570A1 (en) | Sac for use in spinal surgery | |
| CN100366303C (en) | Preparation and application of anti blocking biomembrane for tendon and ligament | |
| CN218075445U (en) | Umbilical hole shaping surgical application | |
| EP2379003B1 (en) | Planar implant for sealing liquid and/or air leaks in the human and/or animal body, and method for its production | |
| CN206228466U (en) | A kind of cranium face, nose repair sticking patch | |
| CN211834923U (en) | Novel fracture fixation device | |
| CN211300577U (en) | Fixing device for fracture part | |
| CN204600787U (en) | Band mesh shape support composite membrane is repaired at the bottom of basin | |
| CN219553132U (en) | First surgical operation teaching aid | |
| CN221556129U (en) | Hernia repair patch with good air permeability | |
| CN214908642U (en) | Hernia repair patch with novel woven mesh |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: BAIJING TIANTAN HOSPITAL Free format text: FORMER OWNER: LIU BAIYUN Effective date: 20110316 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100050 DEPARTMENT OF NEUROSURGERY, BEIJING TIANTAN HOSPITAL, NO. 6, TIANTANXILI, BEIJING TO: 100050 NO. 6, TIANTAN XILI, BEIJING |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20110316 Address after: 100050 No. 6, West Lane, Tiantan, Beijing Applicant after: Baijing Tiantan Hospital Address before: 100050 Department of Neurosurgery, Beijing Tiantan Hospital, 6 West Lane, Beijing, China Applicant before: Liu Baiyun |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110518 Termination date: 20130320 |