CN1830425A - Preparation method of acetyl glutamine injection - Google Patents
Preparation method of acetyl glutamine injection Download PDFInfo
- Publication number
- CN1830425A CN1830425A CN 200510051466 CN200510051466A CN1830425A CN 1830425 A CN1830425 A CN 1830425A CN 200510051466 CN200510051466 CN 200510051466 CN 200510051466 A CN200510051466 A CN 200510051466A CN 1830425 A CN1830425 A CN 1830425A
- Authority
- CN
- China
- Prior art keywords
- injection
- preparation
- lucifuge
- prescription
- minutes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
An acetylglutamide injection for improving brain function and treating coma, palsy, hypointelligence, dysmnesia, etc is prepared through mixing acetylglutamide and phosphate buffering liquid, ultrasonic treating, cold storage, ultrafiltration, mixing with Na2EDTA solution in dark condition, pouring in containers, sterilizing and lamp examining.
Description
Technical field
The present invention relates to a kind of preparation method of medicine for improving brain function acetyl glutamine injection, specifically, relating to a kind of is the small-volume injection of main composition with aceglutamide, aceglutamide and phosphate buffer are prepared jointly, through technical finesses such as ultrasonic, cold preservation, ultrafiltration, obtain the aceglutamide ultrafiltrate, under the lucifuge condition again with after Calcium Disodium Versenate solution mixes, fill, make small-volume injection through sterilization, lamp inspection, packing at last, belong to the chemical preparation field.This product can intravenous drip can intravenous drip through the clinical trial proof, aceglutamide is decomposed into glutamic acid γ-An Jidingsuan (GABA) after by blood brain-spinal fluid barrier, participate in central nervous system's information transmission, participate in protein and carbohydate metabolism, the pair cell reparation plays an important role, can improve the neurocyte metabolism, keep the effect of neural stress ability and reduction blood ammonia, improve brain function.Be mainly used in stupor, paralysis and the hypophrenia that hepatic coma, hemiplegia, neurosurgery etc. cause, memory disorder etc.
Background technology
Aceglutamide has another name called aceglutamide, also is called cerebrin, is the acetyl compound of glutamine, for brain function, function of nervous system improve medicine, has the effect that improves the neurocyte metabolism, keeps neural emergency function and reduction blood ammonia.By blood brain barrier, directly act on cerebral cortex, have the effect of activation, protection and reparation neurocyte, improve the function of brain.Promote the utilization of brain, strengthen the running of big brain energy metabolism, accelerate brain function and recover oxygen and glucose.Widely distributed in vivo, can see through blood brain barrier, higher with brain, liver, kidney concentration, in renal tubular cell, decompose through glutamic acid, decomposite ammonia and become aceglutamide acid, ammonia is discharged from tubular secretion, and aceglutamide acid is absorbed, and participates in internal metabolism,
At present, the acetyl glutamine injection on the domestic market has many enterprises to produce, and all adopts traditional handicraft formulated, the constant product quality of its existence is poor, and the medicinal liquid zest is strong, clarity disqualification rate height, pH value descends, and content descends, and problems such as curative effect instability can't solve all the time.I have fundamentally solved the problems referred to above at the breakthrough of company's acetyl glutamine injection technology.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of acetyl glutamine injection.
Preparation method of the present invention comprises the steps: earlier aceglutamide and phosphate buffer to be prepared jointly, through technical finesses such as ultrasonic, cold preservation, ultrafiltration, obtain the aceglutamide ultrafiltrate, under the lucifuge condition again with after Calcium Disodium Versenate solution mixes, fill is made small-volume injection through sterilization, lamp inspection, packing at last.
Preparation method detailed process of the present invention is as follows:
A) get 70～90%80～90 ℃ of fresh water for injection of amount of preparation, add sodium hydrogen phosphate, sodium dihydrogen phosphate in the prescription, stirring and dissolving is cooled to 10～25 ℃, transfers pH5.0～6.0, lucifuge, add the aceglutamide in the prescription, supersound process 10～30 minutes, 0～10 ℃ of cold preservation 12～48 hours, with the ultrafilter membrane ultrafiltration of molecular cut off 10,000～30,000, get ultrafiltrate.
B) get the fresh water for injection of 5～15%80～90 ℃ of amount of preparation, add the Calcium Disodium Versenate in the prescription, stirring and dissolving, add 0.05～0.5% active carbon, heated and boiled 15～30 minutes, be cooled to 30～60 ℃ after, with 0.45 μ m filter membrane decarbonization filtering, get ultrafiltrate.
C) above-mentioned two kinds of medicinal liquids are mixed under the lucifuge condition, supersound process is standardize solution after 10～30 minutes, adjust pH 5.0～6.5, intermediate products after the assay was approved, through 0.22 μ m filter membrane aseptic filtration, lucifuge, cold preservation, sterilization, lamp inspection, packing promptly get the acetyl glutamine injection finished product with medicinal liquid.
More preferred manufacturing procedure comprises the steps:
A) get 90%80 ℃ of fresh water for injection of amount of preparation, add sodium hydrogen phosphate, sodium dihydrogen phosphate in the prescription, stirring and dissolving is cooled to 20 ℃, transfers pH5.5, lucifuge, add the aceglutamide in the prescription, supersound process 15 minutes, 4 ℃ of cold preservation 24 hours, with the ultrafilter membrane ultrafiltration of molecular cut off 10,000, get ultrafiltrate.
B) get the fresh water for injection of 10%80 ℃ of amount of preparation, add the Calcium Disodium Versenate in the prescription, stirring and dissolving adds 0.1% active carbon, heated and boiled 20 minutes, be cooled to 50 ℃ after, with 0.45 μ m filter membrane decarbonization filtering, must ultrafiltrate.
C) above-mentioned two kinds of medicinal liquids are mixed under the lucifuge condition, supersound process is standardize solution after 10 minutes, adjust pH 5.5, intermediate products after the assay was approved, through 0.22 μ m filter membrane aseptic filtration, lucifuge, cold preservation, sterilization, lamp inspection, packing promptly get the acetyl glutamine injection finished product with medicinal liquid.
In the above-mentioned preparation method, adopting the molecular weight that dams is 10,000 ultrafilter membrane ultrafiltration, is the controlled step of invalid element in institute's preparating liquid, and used ultrafilter membrane is the commercially available prod.Its manufacturer should be the production unit of industry approval.
In the above-mentioned preparation method, the lucifuge condition is the committed step of medicinal liquid preparation, pouring process.
In the above-mentioned preparation method, the employed filter membrane of terminal aseptic filtration aperture is 0.22 μ m.For making constant product quality, filter membrane should be as far as possible by fixedly manufacturer's supply.
In the above-mentioned preparation method, for making constant product quality, used pH value regulator is 30% sodium hydroxide solution, and pH value is strict controlled in 5.5～6.5.
Intravenous drip during acetyl glutamine injection clinical practice of the present invention is slowly instiled with 5% or 10% glucose solution 250ml dilution back.
Acetyl glutamine injection of the present invention is that brain function, function of nervous system improve medicine, has the effect that improves the neurocyte metabolism, keeps neural emergency function and reduction blood ammonia.By blood brain barrier, directly act on cerebral cortex, have the effect of activation, protection and reparation neurocyte, improve the function of brain.Promote the utilization of brain, strengthen the running of big brain energy metabolism, accelerate brain function and recover oxygen and glucose.Be mainly used in stupor, paralysis and the hypophrenia that hepatic coma, hemiplegia, neurosurgery etc. cause, memory disorder etc.
The common preparation of aceglutamide and phosphate buffer and handle in the process of the present invention through cold preservation, ultrasonic, hyperfiltration technique, technological parameters such as strict simultaneously control pH value, temperature, concentration, ionic strength, guaranteed that invalid element is removed fully, effectively avoided the hydrolysis of aceglutamide, reduced the related substance in the preparation, made that better stability of preparation, the zest made are little, clarity is improved, clinical efficacy is definite.
The specific embodiment
Further describe the present invention with embodiment below, but described embodiment only is used to illustrate the present invention rather than restriction the present invention.
Embodiment 1
A) get 70%80 ℃ of fresh water for injection of amount of preparation, add sodium hydrogen phosphate, sodium dihydrogen phosphate in the prescription, stirring and dissolving is cooled to 15 ℃, transfers pH6.0, lucifuge, add the aceglutamide in the prescription, supersound process 15 minutes, 4 ℃ of cold preservation 24 hours, with the ultrafilter membrane ultrafiltration of molecular cut off 10,000, get ultrafiltrate.
B) get the fresh water for injection of 15%80 ℃ of amount of preparation, add the Calcium Disodium Versenate in the prescription, stirring and dissolving adds 0.1% active carbon, heated and boiled 25 minutes, be cooled to 40 ℃ after, with 0.45 μ m filter membrane decarbonization filtering, must ultrafiltrate.
C) above-mentioned two kinds of medicinal liquids are mixed under the lucifuge condition, supersound process is standardize solution after 15 minutes, adjust pH 5.8, intermediate products after the assay was approved, through 0.22 μ m filter membrane aseptic filtration, lucifuge, cold preservation, sterilization, lamp inspection, packing promptly get the acetyl glutamine injection finished product with medicinal liquid.
Embodiment 2
A) get 80%90 ℃ of fresh water for injection of amount of preparation, add sodium hydrogen phosphate, sodium dihydrogen phosphate in the prescription, stirring and dissolving is cooled to 25 ℃, transfers pH5.7, lucifuge, add the aceglutamide in the prescription, supersound process 30 minutes, 6 ℃ of cold preservation 12 hours, with the ultrafilter membrane ultrafiltration of molecular cut off 10,000, get ultrafiltrate.
B) get the fresh water for injection of 15%80 ℃ of amount of preparation, add the Calcium Disodium Versenate in the prescription, stirring and dissolving adds 0.2% active carbon, heated and boiled 15 minutes, be cooled to 50 ℃ after, with 0.45 μ m filter membrane decarbonization filtering, must ultrafiltrate.
C) above-mentioned two kinds of medicinal liquids are mixed under the lucifuge condition, supersound process is standardize solution after 10 minutes, adjust pH 6.2, intermediate products after the assay was approved, through 0.22 μ m filter membrane aseptic filtration, lucifuge, cold preservation, sterilization, lamp inspection, packing promptly get the acetyl glutamine injection finished product with medicinal liquid.
Embodiment 3
A) get 75%85 ℃ of fresh water for injection of amount of preparation, add sodium hydrogen phosphate, sodium dihydrogen phosphate in the prescription, stirring and dissolving is cooled to 20 ℃, transfers pH5.0, lucifuge, add the aceglutamide in the prescription, supersound process 25 minutes, 6 ℃ of cold preservation 12 hours, with the ultrafilter membrane ultrafiltration of molecular cut off 10,000, get ultrafiltrate.
B) get the fresh water for injection of 5%85 ℃ of amount of preparation, add the Calcium Disodium Versenate in the prescription, stirring and dissolving adds 0.4% active carbon, heated and boiled 30 minutes, be cooled to 60 ℃ after, with 0.45 μ m filter membrane decarbonization filtering, must ultrafiltrate.
C) above-mentioned two kinds of medicinal liquids are mixed under the lucifuge condition, supersound process is standardize solution after 25 minutes, adjust pH 5.7, intermediate products after the assay was approved, through 0.22 μ m filter membrane aseptic filtration, lucifuge, cold preservation, sterilization, lamp inspection, packing promptly get the acetyl glutamine injection finished product with medicinal liquid.
Embodiment 4
A) get 90%85 ℃ of fresh water for injection of amount of preparation, add sodium hydrogen phosphate, sodium dihydrogen phosphate in the prescription, stirring and dissolving is cooled to 15 ℃, transfers pH5.4, lucifuge, add the aceglutamide in the prescription, supersound process 10 minutes, 8 ℃ of cold preservation 48 hours, with the ultrafilter membrane ultrafiltration of molecular cut off 10,000, get ultrafiltrate.
B) get the fresh water for injection of 10%85 ℃ of amount of preparation, add the Calcium Disodium Versenate in the prescription, stirring and dissolving adds 0.05% active carbon, heated and boiled 25 minutes, be cooled to 30 ℃ after, with 0.45 μ m filter membrane decarbonization filtering, must ultrafiltrate.
C) above-mentioned two kinds of medicinal liquids are mixed under the lucifuge condition, supersound process is standardize solution after 30 minutes, adjust pH 6.1, intermediate products after the assay was approved, through 0.22 μ m filter membrane aseptic filtration, lucifuge, cold preservation, sterilization, lamp inspection, packing promptly get the acetyl glutamine injection finished product with medicinal liquid.
Embodiment 5
A) get 85%80 ℃ of fresh water for injection of amount of preparation, add sodium hydrogen phosphate, sodium dihydrogen phosphate in the prescription, stirring and dissolving is cooled to 20 ℃, transfers pH5.8, lucifuge, add the aceglutamide in the prescription, supersound process 20 minutes, 5 ℃ of cold preservation 36 hours, with the ultrafilter membrane ultrafiltration of molecular cut off 10,000, get ultrafiltrate.
B) get the fresh water for injection of 15%80 ℃ of amount of preparation, add the Calcium Disodium Versenate in the prescription, stirring and dissolving adds 0.5% active carbon, heated and boiled 20 minutes, be cooled to 50 ℃ after, with 0.45 μ m filter membrane decarbonization filtering, must ultrafiltrate.
C) above-mentioned two kinds of medicinal liquids are mixed under the lucifuge condition, supersound process is standardize solution after 20 minutes, adjust pH 5.9, intermediate products after the assay was approved, through 0.22 μ m filter membrane aseptic filtration, lucifuge, cold preservation, sterilization, lamp inspection, packing promptly get the acetyl glutamine injection finished product with medicinal liquid.
Experimental example 1
The detection of relevant every gainer under character, pH value and the injection item of this experimental example for the prepared acetyl glutamine injection of the present invention.
Character: this product is colourless clear liquid, and is up to specification.
PH value: get this product, measure (two appendix VIH of Chinese Pharmacopoeia version in 2000) in accordance with the law, pH value is 4.5～7.0, and is up to specification.
Other: meet every regulation relevant under the injection item (two appendix IB of Chinese Pharmacopoeia version in 2000).
Experimental example 2
This experimental example is the qualitative determination of the prepared acetyl glutamine injection of the present invention.
Differentiate: get the about 5ml of this product, add hydrochloric acid solution (1 → 2) 2ml, about 30 minutes of heated and boiled, and constantly keep the skin wet, it is 5～6 that pH is regulated in the cooling back, removes this product 2ml, adds the about 2mg of 1,2,3-indantrione monohydrate, places or heating, solution shows bluish violet, and is up to specification
Contain definite component in the prepared acetyl glutamine injection of above description of test the present invention.
Experimental example 3
This experimental example is the assay of the prepared acetyl glutamine injection of the present invention.
Assay: precision is measured this product an amount of (being equivalent to aceglutamide 0.25g approximately) and is put in the alembic, add 200ml water and 20% sodium hydroxide solution 75ml, add thermal distillation, distillate imports and to contain C.I. 13020 .-bromocresol green and mix among the 4% boric acid solution 40ml of indicator solution number droplet, slowly boils 20 minutes earlier, increases firepower immediately, ammonia heats up in a steamer only, stop distillation, use sulphuric acid titration (0.5mol/L) titration, and titration results is proofreaied and correct with blank assay.Every 1ml sulphuric acid volumetric solution (0.5mol/L) is equivalent to the C of 18.82mg
7H
12N
2O
4
Standard code: contain aceglutamide (C
7H
12N
2O
4) should be 90%～110% of labelled amount.
Assay by three batches the results are shown in following table:
| Lot number | Labelled amount (%) |
| 20040501 | 101.2 |
| 20040502 | 99.8 |
| 20040503 | 100.6 |
Experimental example 4
This experimental example is the security inspection of the prepared acetyl glutamine injection of the present invention.
Aseptic: get this product, check (two appendix XIH of Chinese Pharmacopoeia version in 2000) in accordance with the law, up to specification.
Pyrogen: press two appendix XID of Chinese Pharmacopoeia version in 2000 and check, up to specification.
Long term toxicity is measured: successive administration was observed the hematuria inspection in three months, pathologic finding there is no unusually.
Safety by the prepared acetyl glutamine injection of above description of test the present invention meets the injection requirement, does not have any toxic action, uses human body safety.
Comparative example 1
The clarity of the acetyl glutamine injection that this comparative example explanation the present invention is prepared is better than producing with conventional preparation method.
The clarity criterion:
(1) finds no foreign body or only be with micro-white point person, the lattice theory of making a match.
(2) every bottle contains the hair that is shorter than 0.5cm and the white point of 0.1～0.2mm, white piece or color dot sum above 5 persons, the lattice theory of making a match.
(3) disqualification rate surpasses 5%, this batch product lattice theory of making a match.Relevant notion:
White piece: mean with the inspection method of regulation, can see the whiteness that tangible plane or corner angle are arranged.
White point: can not differentiate plane or corner angle by white point.
Trace white point: in official hour, only see 3 or 3 following white point persons.
Foreign body: comprise chips of glass, fiber, color dot, color lump and other external foreign body.
Inspection method:
Get respectively and adopt prepared acetyl glutamine injection of the present invention and each 200 of the products that adopts the common process preparation,, the results are shown in following table by " clarity test detailed rules and regulations and criterion " and above standard inspection.
| Group | The trace white point | White point | White piece | Foreign body | Number of non-compliances | Disqualification rate | Qualification rate | Conclusion |
| The invention group | 7 | 1 surpasses 5 | 0 | 0 | 1 | 0.5％ | 99.5％ | Qualified |
| Conventional group | 70 | 7 surpass 5 | 3 surpass 5 | 0 | 10 | 5％ | 95％ | Qualified |
Clarity by the prepared acetyl glutamine injection of above description of test the present invention obviously is better than producing with conventional preparation method.
Comparative example 2
This comparative example illustrates that the prepared acetyl glutamine injection zest when clinical practice of the present invention is less.
| Group | The invention group | Conventional group |
| Usage and dosage | Intramuscular injection, 100～600mg on the one; Child dose cuts down according to the circumstance.Intravenous drip is slowly instiled with 5% or 10% glucose solution 250ml dilution back. | Intramuscular injection, 100～600mg on the one; Child dose cuts down according to the circumstance.Intravenous drip is slowly instiled with 5% or 10% glucose solution 250ml dilution back. |
| Clinical practice | ||
| Zest is observed | No pain and untoward reaction phenomenon | 14 examples have the pain phenomenon, and the injection site is all rubescent |
Comparative example 3
The prepared various trace elements injection of this comparative example explanation employing the present invention compares with the stability of the various trace elements injection that adopts conventional preparation method to produce by six months accelerated tests, the results are shown in following table.
Standard code: content: contain aceglutamide (C
7H
12N
2O
4) should be 90%～110% of labelled amount.
PH value: should be 4.5～7.0
Clarity: qualification rate should be not less than 95%
Color: colourless clear liquid
By above experiment as can be seen, the invention group was passed through accelerated tests after six months, significant change does not take place in its content, pH value, clarity, color, and content, the pH value of conventional group all have obvious reduction, clarity, color are all against regulation, show that the prepared acetyl glutamine injection of the present invention obviously is better than adopting conventional preparation method to be produced.
Claims (8)
1. the preparation method of an acetyl glutamine injection, described preparation method detailed process is as follows:
A) get fresh water for injection, add sodium hydrogen phosphate, sodium dihydrogen phosphate in writing out a prescription, stirring and dissolving, pH is transferred in cooling, lucifuge, after the aceglutamide supersound process in the adding prescription, shading, cold preservation, ultrafiltration gets ultrafiltrate;
B) get fresh water for injection, the Calcium Disodium Versenate in the adding prescription, stirring and dissolving adds active carbon, heated and boiled, cooling back decarbonization filtering gets filtrate;
C) above-mentioned two kinds of medicinal liquids are mixed under the lucifuge condition, supersound process, standardize solution, adjust pH, intermediate products after the assay was approved, through end-filtration, lucifuge, cold preservation, sterilization, lamp inspection, packing promptly get the acetyl glutamine injection finished product with medicinal liquid.
2. according to claims 1 described preparation method, it is characterized in that comprising the steps:
A) get 70～90%80～90 ℃ of fresh water for injection of amount of preparation, add sodium hydrogen phosphate, sodium dihydrogen phosphate in the prescription, stirring and dissolving is cooled to 10～25 ℃, transfers pH5.0～6.0, lucifuge, add the aceglutamide in the prescription, supersound process 10～30 minutes, 0～10 ℃ of cold preservation 12～48 hours, with the ultrafilter membrane ultrafiltration of molecular cut off 10,000～30,000, get ultrafiltrate;
B) get the fresh water for injection of 5～15%80～90 ℃ of amount of preparation, add the Calcium Disodium Versenate in the prescription, stirring and dissolving, add 0.05～0.5% active carbon, heated and boiled 15～30 minutes, be cooled to 30～60 ℃ after, with 0.45 μ m filter membrane decarbonization filtering, get ultrafiltrate;
C) above-mentioned two kinds of medicinal liquids are mixed under the lucifuge condition, supersound process is standardize solution after 10～30 minutes, adjust pH 5.0～6.5, intermediate products after the assay was approved, through 0.22 μ m filter membrane aseptic filtration, lucifuge, cold preservation, sterilization, lamp inspection, packing promptly get the acetyl glutamine injection finished product with medicinal liquid.
3. according to claims 1 described preparation method, it is characterized in that comprising the steps:
A) get 90%80 ℃ of fresh water for injection of amount of preparation, add sodium hydrogen phosphate, sodium dihydrogen phosphate in the prescription, stirring and dissolving is cooled to 20 ℃, transfers pH5.5, lucifuge, add the aceglutamide in the prescription, supersound process 15 minutes, 4 ℃ of cold preservation 24 hours, with the ultrafilter membrane ultrafiltration of molecular cut off 10,000, get ultrafiltrate;
B) get the fresh water for injection of 10%80 ℃ of amount of preparation, add the Calcium Disodium Versenate in the prescription, stirring and dissolving adds 0.1% active carbon, heated and boiled 20 minutes, be cooled to 50 ℃ after, with 0.45 μ m filter membrane decarbonization filtering, must ultrafiltrate.；
C) above-mentioned two kinds of medicinal liquids are mixed under the lucifuge condition, supersound process is standardize solution after 10 minutes, adjust pH 5.5, intermediate products after the assay was approved, through 0.22 μ m filter membrane aseptic filtration, lucifuge, cold preservation, sterilization, lamp inspection, packing promptly get the acetyl glutamine injection finished product with medicinal liquid.
4. according to claims 1,2 or 3A) in the injection water yield be 70～90% of amount of preparation, its temperature is controlled at 10～25 ℃ during formulated product.
5. according to claims 1,2 or 3 described B) in the amount of active carbon be 0.05～0.5%, boiling time is 15～30 minutes, taking off the charcoal temperature is 30～60 ℃.
6. according to claims 1,2 or 3 described preparation methoies, pH is controlled at 5.5～6.5 when it is characterized in that formulated product.Used pH value regulator is 30% sodium hydroxide solution.
7. according to claims 1,2 or 3 described preparation methoies, the time that it is characterized in that supersound process is 10～30 minutes.Ultrasonic employed ultrafilter membrane is the ultrafilter membrane of molecular cut off 10,000～30,000.
8. according to claims 1,2 or 3 described preparation methoies, it is characterized in that the condition in process for preparation is a lucifuge.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510051466 CN1830425A (en) | 2005-03-08 | 2005-03-08 | Preparation method of acetyl glutamine injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510051466 CN1830425A (en) | 2005-03-08 | 2005-03-08 | Preparation method of acetyl glutamine injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1830425A true CN1830425A (en) | 2006-09-13 |
Family
ID=36993027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510051466 Pending CN1830425A (en) | 2005-03-08 | 2005-03-08 | Preparation method of acetyl glutamine injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1830425A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018668A (en) * | 2010-12-08 | 2011-04-20 | 上海朝晖药业有限公司 | Preparation method of aceglutamide |
-
2005
- 2005-03-08 CN CN 200510051466 patent/CN1830425A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018668A (en) * | 2010-12-08 | 2011-04-20 | 上海朝晖药业有限公司 | Preparation method of aceglutamide |
| CN102018668B (en) * | 2010-12-08 | 2012-01-18 | 上海朝晖药业有限公司 | Preparation method of aceglutamide |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102626409B (en) | A kind of pharmaceutical composition containing 18 seed amino acids | |
| CN103989630B (en) | Moxifloxacin hydrochloride injection and preparation method thereof | |
| CN101045042A (en) | Propofol injection and its preparing method | |
| CN1830438A (en) | Preparation method of vitamin C freeze dried powder injection | |
| CN1830431A (en) | Preparation method of potassium magnesium aspartate freeze dried powder injection | |
| CN1830425A (en) | Preparation method of acetyl glutamine injection | |
| CN1830455A (en) | Preparation method of multi-kind micro-element injection | |
| CN1830440A (en) | Metronidazule injection and its preparation method and use | |
| CN100340245C (en) | Bone strengthening oral liquor and its preparing method | |
| CN1429558A (en) | Mannosan peptide injection and its preparation and use method | |
| CN1830453A (en) | Preparation method of vitamin medicinal composition | |
| CN1264522C (en) | Medicinal composition, its preparation method and its use | |
| CN1939357A (en) | Preparation of Ginkgo Damo injection | |
| CN1732936A (en) | Nimodipine emulsion injection liquid and method for preparing the same | |
| CN1830427A (en) | Preparation method of sodium ferulate freeze dried powder injection | |
| CN1184963C (en) | Bromhexine hydrochloride injection and its preparation method | |
| CN1830443A (en) | Preparation method of sophora flavescens freeze dried powder injection | |
| CN1830439A (en) | Preparation method of metronidazole freeze dried powder injection | |
| CN1830434A (en) | Preparation method of troxerutin injection | |
| CN1686342A (en) | Herminium drip pill and its preparation method | |
| CN1830452A (en) | Preparation method of clindamycin hydrochloride freeze dried powder injection | |
| CN1830485A (en) | Preparation method of anti-inflammation analgesia medicine compound bone peptide injection | |
| CN1751691A (en) | Small volume intravenous injection of gastrodine and its prepn. method | |
| CN1557302A (en) | Carbazochrome Sodium Sulfonate infusion and its preparation method | |
| CN1830433A (en) | Preparation method of tanshinone IIA sodium sulphonate small volume injection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhang Huifang Document name: Notice of publication of application for patent for invention |
|
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhang Huifang Document name: Notification before expiration of term |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhang Huifang Document name: Notification of the application for patent for invention to go through the substantive examination procedure |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |