CN1823955A - Medicine and food dual purpose Chinese medicinal preparation for preventing and treating alimentary canal parasile and its manufacturing method - Google Patents

Abstract

A Chinese medicine used as both medicine and food for preventing and treating the parasites in digestive tract is prepared from 6 Chinese-medicinal materials including sophora flower, black plum, Chinese prickly ash, anise, etc. Its preparing process is also disclosed.

Description

Control enteron parasite dietotherapeutic Chinese medicine preparation and manufacture method

Chinese medicine and western modern medicine disease preventing and treating theory one significantly difference be that the former does not rest on analysis to the concrete cause of disease to pathological knowledge, show the nonantagonistic latter and then be antagonism, that is the former emphasizes is human body integral and the ability that how improves the antagonism disease from integral body, the latter then is that " sitting in the right seat " is as what microorganism, malnutrition or surplus, poisonous and harmful substance (comprising medicine) and effect etc. cause any disease, though theoretic dispute is very big, even opposition and antagonism, whom shows under a lot of situations whom does not persuade, mutual contradiction or do not have public opinion even, undisputable fact really but they can both be cured the disease and/or reach a cure, this also proved human to medicine especially in, cognitive level and ability between western modern medicine is mutual are also very limited, and arbitrarily in the dogmatize about, the western modern medicine theory who to whose mistake, can not declare that more which is right and which is wrong, because both sides do not have enough conclusive evidences to prove that the other side is wrong, so do not meet the view of science, so should advocate the pardon scientific research of promptly taking facts as the basis and deepen continuously progressively gets and improves relevant theoretical dispute clear with practice and argue, thereby in constantly enriching, the theoretical treasure-house of western modern medicine, make the two can both more effectively be human good health and a long life service, but not argue for arguement, even be negative arbitrarily even attack the other side, not science and responsible attitude and behavior because do like this by lack of evidence ground to argue, all be unfavorable for ensureing and developing human medical and health care system.

Along with the development of medical and health care system, various parasitic disease also reduce gradually to some extent, but this is not just can sleep without any anxiety but on the contrary, and for example some provincialism and seasonal various parasitic disease such as schistosomicide are not only seen disappearance, on the contrary the fact that increases the weight of arranged.The situation of various enteron parasite diseases similarly, many local bounce-backs and harm are also very serious, in present this class disease of control, the Western medicine product substantially all are to lay particular stress on treatment, poison, side effect is just more common, in no matter the more important thing is, the all rare officinal food dual purpose product of Western medicine, this is to forbid unauthorized medicine to use food (comprising health product) in any form because consider all to make laws from drug safety in China and a lot of countries and regions, otherwise call to account in accordance with the law, and that disease reaches the degree of essential treatment is very serious, say on the clinical meaning and increase the treatment difficulty greatly, let alone puted prevention first, even if also just can sell medicine as the U.S. because of the prescription drugs pharmacy that must the doctor prescribes in developed country and area, otherwise it is illegal, consumer then must pay expenses such as high prescription takes and surpass medicine valency itself outward, and nonprescription drugs, health food is that the dietotherapeutic product then need not prescription and expensive expense thereof, has alleviated consumer's financial burden greatly and made to buy to consume simple and direct and increase purchasing power, fulfill thereby making puts prevention first.Therefore unique legal effectively, economically feasible, to put prevention first, prevent and treat the scheme of taking into account just can only be screening, combination and design relevant new departure and new product in view of the above in legal dietotherapeutic medicine scope, because of such product could really accomplish good and cheap, consumer channel is unblocked, service group is extensive, its disease preventing and treating function and curative effect, safety and crowd's general applicability could also must gain public acceptance and serial relevant law such as state food health legislation is approved and protect.Total be exactly the present invention at prior art not enough, for one for solve an above-mentioned serial difficult problem inventive concept the control enteron parasite dietotherapeutic Chinese medicine preparation and the manufacture method that design, main Chinese medicine principle and functional advantage that its health that adopts officinal promulgated by the ministries or commissions of the Central Government is eaten dual-purpose raw material of Chinese medicine and the property of medicine and foundation are described below.

Flos Sophorae bitter in the mouth, anal fistula hemorrhoidal hamorrhage, large intestine hematodiarrhoea, more kill ascarid.Flos Sophorae bitter in the mouth, cold nature, anal fistula archorrhagia and stool hematochezia are controlled in cooling blood for hemostasis, and control large intestine and the dysentery of heat is arranged and kill ascarid, also control diseases such as haematemesis, epistaxis and women's metrorrhagia.

Fructus Mume acid temperature, convergence lung qi, slake thirst and help produce saliva, can pacify dysentery.Fructus Mume sour in the mouth, warm in nature has the effect of convergence lung qi, promoting the production of body fluid to quench thirst, can control the diabetes of the more than and deficiency of body fluid of the chronic cough of insufficiency of lung-QI, and the energy astringing intestine to stop diarrhea, controls the chronic diarrhea chronic dysentery again.This product also has the effect of relieving colic caused by ascaris worm, and Gu has the saying of " worm get sour then volt ", that is to say that ascarid is to be afraid of acid, so commonly used its treated the ascarid contrary vomiting stomachache etc. of fainting again.This product external is wiped tooth and can be controlled the tooth official and close, mouthful can not open.

Pericarpium Zanthoxyli is hot, uncharm by the parasite killing of trembling with fear, make eye bright, temperature and not violent.The Pericarpium Zanthoxyli acrid in the mouth is warm in nature, the warming the spleen stomach is arranged, by cold-damp, parasiticidal effect, be applicable to diseases such as breast abdomen cold type of pain or dysentery stomachache and vomiting ascarid, fiercely can also not make eye bright so it is warm in nature.

The Semen Torreyae sweet in the mouth, main treat five hemorrhoid, diseases due to noxious agents produced by various parasites three worms, can not polyphagia.Semen Torreyae sweet in the mouth, property are flat, are parasite killing, the long-pending main medicine that helps digestion, and the intestine moistening laxative action is arranged, and can control the diseases such as stomachache of hemorrhoid dyschesia and multiple malnutrition due to parasitic infestation.Because of can intestine moistening so can not take more, probably to cause lingering diarrhea more than.

Herba Portulacae is cold, optic atrohic blindness nebula, salty the controlling of convenient parasite killing, Disorder carbuncle.The Herba Portulacae sour in the mouth is cold in nature, and the loose effect of blood of heat clearing away, detoxifcation, parasite killing is arranged, and can control the blurring of vision that pyretic toxicity causes or gives birth to the nebula film and swell and ache and toxic-heat and blood stasis.In addition, can loose blood so all can treat because of this product to not all right De mass in the abdomen of blood stasis and carbuncle.

The Fructus Anisi Stellati conventional Chinese medicine, the beginning is stated from " Bencao Pinhui Jingyao ", anthelmintic is arranged, is good for the stomach, effects such as cold relieving, excitor nerve.Modern study shows that its alcohol extract is to gram-positive bacterium, and negative bacteria and common pathogenic dermatophytes have inhibitory action.Be used for the treatment of the stomach feeling of distension and oppression, the vomiting of catching cold, abdominal distention, stomachache, colicky, diseases such as waist cold type of pain.

Product of the present invention is by legal dietotherapeutic Chinese crude drug Flos Sophorae 1.5-3 part, and Fructus Mume 1-3 part, Pericarpium Zanthoxyli 0.5-3 part, Semen Torreyae 3-5 part, Herba Portulacae 1.5-3 part, Fructus Anisi Stellati 0.3-1 part are that raw material of Chinese medicine is formed.

The manufacture method of product of the present invention is as follows:

A. decoction pieces type Chinese crude drug Flos Sophorae 1.5-3 part is on the waiting list in the choosing of raw material Chinese medicine, Fructus Mume 1-3 part, Pericarpium Zanthoxyli 0.5-3 part, Semen Torreyae 3-5 part, Herba Portulacae 1.5-3 part, Fructus Anisi Stellati 0.3-1 part joins in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heater;

Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage (solubilized many be insoluble in the material of water and significantly improve drug effect) and adds the dilution of room temperature drinking water that to make ethanol (dense) degree be that alcohol content is the organic mixed solvent (mixed solution for extraction object Chinese medicinal ingredients material different liquids still can be considered solvent) with inorganic two kinds of solvent compositions of the sterilization type of 55-75% (V/V is a volume ratio), and alcoholic strength is lower than 55% or be higher than 75% equal difficulty and reach optimum extraction and sterilization effect;

C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 2060 rev/mins of rotating speed agitating solutions and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of ethanol boiling point (to reduce evaporation of water and distillation as far as possible) vaporization ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, ensure that extracting solution utmost point low organic solvent is the high-quality of alcohol content, used cooling water extracts water as preheating, these measure and ensures the low energy consumption of production and product, low water consumption, low-cost, and avoided the pollution of organic solvent to environment and product, the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;

D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container room temperature (because of contain the few breeding of bacterium limited guarantee not putrid and deteriorated) soaked Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;

E. inorganic solvent is proceeded to add (height) warm extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, add simultaneously (height) temperature (so the time contain bacterium may be than d for high) lower the temperature slowly naturally after 3-5 minute to boiling that (summer high temperature was lowered the temperature and can suitably be aided with the room temperature water-cooled too slowly in about 20-30 minute, the same recyclable described preheating water of c of incorporating into of cooling water) continues stripping and energy-saving and water-saving to 60-70 ℃ in order to pharmaceutical compositions, extract and must high temperature could propose and low temperature is not carried most material composition, and make and heat rapidly and evenly, reduce material damage and loss, with further raising drug effect and recovery rate, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, the medicinal residues that discard behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed are the acyclic dirts of agricultural soil high-quality fertilizer of returning crop stocks to the field, and medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;

F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;

G. the preparation of product of the present invention is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, lactose is added Chinese medicine extraction liquid, is the solution dry matter content that concentration promotes and to be 35-40%, be spray dried into water content and get product below 3%, host or additive as food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP; Any shape such as the sheet of compacting (lactose is compression moulding very easily) one-tenth 0.2-0.4 gram, grain, ball as food, nutriment, health product and medicine, are advised oral every day 2-3 time, each 0.4-0.8 gram, need not the branch of crowd and dosage.

The purposes of product of the present invention, usage and consumption: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.

Embodiment:

1, drinks 1.5 parts in sheet type Chinese crude drug Flos Sophorae, 1 part of Fructus Mume, 0.5 part in Pericarpium Zanthoxyli, 3 parts of Semen Torreyaes, 1.5 parts of Herba Portulacaes, 0.3 part of Fructus Anisi Stellati is made compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and gets raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.Be mainly used in the daily life health food that puts prevention first.

2, drink 2 parts in sheet type Chinese crude drug Flos Sophorae, 2 parts of Fructus Mumes, 1 part in Pericarpium Zanthoxyli, 4 parts of Semen Torreyaes, 2 parts of Herba Portulacaes, 0.5 part of Fructus Anisi Stellati is made compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and gets raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.Be mainly used in the light patient of the their early stage or the state of an illness.

3, drink 3 parts in sheet type Chinese crude drug Flos Sophorae, 3 parts of Fructus Mumes, 3 parts in Pericarpium Zanthoxyli, 5 parts of Semen Torreyaes, 3 parts of Herba Portulacaes, 1 part of Fructus Anisi Stellati is made compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and gets raw produce, and the Any shape such as sheet, grain, ball that product of the present invention are pressed into 0.2-0.4 gram get product.Be mainly used in the long or heavier patient of the state of an illness of the course of disease.

Supplementary copy inventive principle and advantage are as follows:

1, it is multi-pronged that the present invention drives away the enteron parasite medication, as with the acid peace earlier of Fructus Mume worm, the property releasing of Pericarpium Zanthoxyli fiber crops or weaken the oscular adsorption function of parasite it easily is purged etc., so painful little and easy expeling of anthelmintic, and do not have Drug resistance putting prevention first property use for a long time and without any side effects.

2, the present invention adopts the low lactose of water absorption to do complexion changed and easy preservation that filler can reduce duration of storage, so storage life is that the commodity shelf life is long, economic worth is high, and constitute most crowds with the acescency of the little sweet and Fructus Mume of lactose, Herba Portulacae and like the popular taste products of " acid is sour-sweet sweet " that eat and easily be accepted, so service face and service group are the most extensive, its society and economic benefit are also just apparent naturally.

3; the property of medicine of Chinese prescription medical material is with flat; temperature; cool; it is main and with flat being slightly cold; the temperate zone cold; cold; also take into account simultaneously and liver (gallbladder); relevant other organ of order after one's own heart; lung; spleen; the protection of the function of kidney and coordination; Chinese medicine organic conception and advantage have been demonstrated fully; make drug effect and function more comprehensive and mark; this double controlling; realized that Chinese medicine property of medicine general inclination is in gentle and promote the high boundary of drug effect mutually; and because of the legal dietotherapeutic of all medical materials; effect certainly and do not have a toxic and side effects; be suitable for any crowd and serve wide, these just the present invention to the imbody of the wide main advantages of Chinese medicine adaptive surface.

4, medicine variety and function all are legal medicine-food two-purposes and simple and clear and do not have a dispute, and the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer has been opened up out Chinese medicine and debated disease and execute tool body content and range of application.

5, all medical materials all are conventional varieties and do not have hormone and toxic and side effects, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.

6, innovate organic and inorganic mixed solvent and extract at room temperature and reclaim organic solvent and recycle molten and water-soluble substances and energy-conservation joint (cooling) water of Extraction oil with being beneficial to synchronously high-quality and high recovery rate, again with inorganic solvent and room temperature and high temperature combined extractive technique, scheme and technology, ensured extraction overall process asepticize, can carry substantially many to the greatest extent be insoluble in water or be insoluble in oil material and significantly improve drug effect and extract quality and content, and extraction ratio height, with short production cycle, energy-saving and water-saving, product cost is low, do not have (organic solvent) and pollute, its serial comprehensive advantage is traditional decocting and single with organic solvent or water or some other is because of expensive, highly difficult, the product of receiving single (fact proved and the generally acknowledged both at home and abroad compound composition extract of Chinese medicine than single composition extract good effect, this was exactly the essence and the inherent feature place of Chinese medicine originally and was determined by it), recovery rate low and short-term even long duration are difficult to that so-called modern Chinese medicine extractive technique that penetration and promotion uses is difficult to mention in the same breath.

7, become the favorable factor of the defective of China and Asia average 80% above population Lactose enzyme indigestibility absorption for want of (as milk) lactose into disease preventing and treating, can significantly slow down the medicine slow release speed and avoid taking the very big and beyond affordability historic difficult problem of traditional decocting Chinese medicine dose because adopt lactose to replace the starch easily digested and assimilated and dextrin to make adsorbent, adhesive and filler, thereby significantly prolong the efficacy of a drug persistent period and improve curative effect and possible medicine irritation is relieved to bottom line.

More than these also are the great novelty and the practicality of the legal approval of Patent Law.

Test method, data and presentation of results: disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, product of the present invention is because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, and make test be easy to just satisfactorily be finished, now further be explained as follows (only for reference) under the prerequisite of necessary KNOW-HOW and business secret and please understand: different sexes allow keeping in Patent Law about situation, it is 2 groups that totally 40 of the patients at age, 20 people are divided into for one group: use product of the present invention and usage and dosage control for one group, one group of not medication compares; Test number and time on test reach first quarter moon, all the event of tool statistical significance has suitable representativeness and credibility.The result is as follows: do not see worm's ovum with check stool in the whole successful anthelmintics of the test group personnel of product of the present invention, January; The state of an illness promptly is significantly improved than the lighter's one week back body constitution and mental status; The matched group experimenter finds the state of an illness person of increasing the weight of 16 people, and 4 people feel no significant change, none state of an illness improver.Prompting: the check stool does not see that worm's ovum has just proved absolutely healing, has been that product of the present invention is effective and effect is remarkable.

To sum up state, raw material of the present invention, product and method belong to a total inventive concept, economic environmental protection good effect, be suitable for the crowd and market is all very wide, helpfulness and the degree of association are also very high.

Claims (3)

1, control enteron parasite dietotherapeutic Chinese medicine preparation, by dietotherapeutic Chinese crude drug Flos Sophorae 1.5-3 part, Fructus Mume 1-3 part, Pericarpium Zanthoxyli 0.5-3 part, Semen Torreyae 3-5 part, Herba Portulacae 1.5-3 part, Fructus Anisi Stellati 0.3-1 part are that raw material of Chinese medicine is formed.

2, the manufacture method of control enteron parasite dietotherapeutic Chinese medicine preparation is as follows:

A. decoction pieces type Chinese crude drug Flos Sophorae 1.5-3 part, Fructus Mume 1-3 part, Pericarpium Zanthoxyli 0.5-3 part are on the waiting list in the choosing of raw material Chinese medicine, Semen Torreyae 3-5 part, Herba Portulacae 1.5-3 part, Fructus Anisi Stellati 0.3-1 part joins in the nonmetallic surface container of belt stirrer, filter and water bath with thermostatic control heater;

Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage and is added the dilution of room temperature drinking water and makes the organic and inorganic mixed solvent that alcohol content is 55-75%V/V;

C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, heater accurately is heated to 78-80 ℃ of vaporization of ethanol boiling point ethanol respectively with medicinal residues and medicinal liquid, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, used cooling water extracts water as preheating, and the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;

D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container soak at room temperature Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;

E. inorganic solvent is proceeded high temperature extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, being warmed to boiling simultaneously slowly lowered the temperature about 20-30 minute to 60-70 ℃ after 3-5 minute naturally, the summer high temperature cooling can suitably be aided with the room temperature water-cooled too slowly, cooling water reclaims incorporates the described preheating water of c into, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, discard medicinal residues behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;

F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;

G. the preparation that prevents and treats enteron parasite dietotherapeutic Chinese medicine preparation is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, lactose is added Chinese medicine extraction liquid, is that concentration promotes and to be 35-40% that being spray dried into water content must product of the present invention 3% below to the solution dry matter content.

3, the purposes of control enteron parasite dietotherapeutic Chinese medicine preparation: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.