CN1823843A - Child ammonia phenol alkyl amine affervescent tablet and its preparation method - Google Patents
Child ammonia phenol alkyl amine affervescent tablet and its preparation method Download PDFInfo
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- CN1823843A CN1823843A CNA2005101205211A CN200510120521A CN1823843A CN 1823843 A CN1823843 A CN 1823843A CN A2005101205211 A CNA2005101205211 A CN A2005101205211A CN 200510120521 A CN200510120521 A CN 200510120521A CN 1823843 A CN1823843 A CN 1823843A
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- alkyl amine
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Abstract
An infantile effervescent tablet of aminophenol alkylamine is prepared proportionally from p-acetylaminopenol, adamantanamine hydrochloride, coffin, artificial bezoar, chlorpheniramine maleate, effervescent agent, filler, flavouring and lubricant.
Description
Technical field
The present invention relates to a kind of child ammonia phenol alkyl amine affervescent tablet of using modern formulation treatment children's Common Cold and preparation method thereof.
Background technology
Child ammonia phenol alkane effervescent tablet is an antipyretic-antalgic class compound recipe Western medicine, be used for the nasal obstruction that Common Cold causes, throat pain, headache, diseases such as heating, the national drug standards disclose this particulate prescription, character, differentiate, check, standards such as assay, clinical practice for many years proves, this granule has good antipyretic-antalgic effect, the oral administration effervescing sheet is novel dosage form, be with a kind of tablet of effervescent material as disintegrating agent, this preparation is specially adapted to the child, the patient of the old people and the solid preparation of can not swallowing, again because of identical with granule be to take with the solution form, drug effect is rapid, the bioavailability height, and compare with liquid preparation, carry more conveniently, receive patient's welcome greatly.
Summary of the invention
The object of the present invention is to provide a kind of child ammonia phenol alkyl amine affervescent tablet and preparation method thereof, its taking convenience, mouthfeel are good.
The present invention is achieved like this, and it comprises principal agent and adjuvant, it is characterized in that principal agent is formulated by the following raw materials in part by weight medicine:
Acetaminophen 100 amantadine hydrochlorides 40 caffeine 6
Artificial Calculus Bovis's 4 chlorphenamine maleate 0.8
Adjuvant is formulated by following substances in parts by weight:
Effervescent 160～240 filleies 80～120
Correctives 32～48 lubricants 2～6
The acid source of described effervescent is a citric acid, and the carbon dioxide source of effervescent is a sodium bicarbonate, and filler is a lactose, and correctives is a protein sugar, and lubricant is a sodium benzoate.Its preparation method is: get acetaminophen, amantadine hydrochloride, caffeine, chlorphenamine maleate and be ground into fine powder, cross 100 mesh sieves; Other gets the artificial Calculus Bovis and is ground into impalpable powder, crosses 325 mesh sieves; The abundant mixing of above-mentioned powder, standby.Get the lactose of above-mentioned 1/2 medicated powder of measuring, 1/2 amount, the protein sugar and the citric acid of 1/2 amount, mixing is granulated with 5% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution, 24 mesh sieves, and is dry below 60 ℃, gets granulates; Other gets remaining above-mentioned medicated powder, lactose, protein sugar and sodium bicarbonate, and mixing is granulated with 5% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution, 24 mesh sieves, and is dry below 60 ℃, sprays into essence, gets the alkali granule.Get above-mentioned granulates and alkali granule, the adding sodium benzoate is an amount of, 24 mesh sieve granulate, and mixing is pressed into 1000, promptly.
The present invention is dosage form improvement on existing particulate basis, uses easy to carryly, is clinical welcome and safe and effective medicine.
The specific embodiment
Embodiment one, get acetaminophen 100g, amantadine hydrochloride 40g, caffeine 6g, chlorphenamine maleate 0.8g are ground into fine powder, cross 100 mesh sieves; Other gets artificial Calculus Bovis 4g and is ground into impalpable powder, crosses 325 mesh sieves; The abundant mixing of above-mentioned powder, standby.Get the protein sugar and the 50g citric acid of above-mentioned 1/2 medicated powder of measuring, 49g lactose, 20g amount, mixing is granulated with 5% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution, 24 mesh sieves, and is dry below 60 ℃, gets granulates; Other gets remaining above-mentioned medicated powder, lactose, protein sugar and sodium bicarbonate, and mixing is granulated with 5% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution, 24 mesh sieves, and is dry below 60 ℃, sprays into essence, gets the alkali granule.Get above-mentioned granulates and alkali granule, the adding sodium benzoate is an amount of, 24 mesh sieve granulate, and mixing is pressed into 1000, promptly.
Claims (3)
1, a kind of child ammonia phenol alkyl amine affervescent tablet, it comprises principal agent and adjuvant, it is characterized in that principal agent is formulated by the following raw materials in part by weight medicine:
Acetaminophen 100 amantadine hydrochlorides 40 caffeine 6
Artificial Calculus Bovis's 4 chlorphenamine maleate 0.8
Adjuvant is formulated by following substances in parts by weight:
Effervescent 160～240 filleies 80～120
Correctives 32～48 lubricants 2～6
2, child ammonia phenol alkyl amine affervescent tablet according to claim 1, the acid source that it is characterized in that described effervescent is a citric acid, and the carbon dioxide source of effervescent is a sodium bicarbonate, and filler is a lactose, and correctives is a protein sugar, lubricant is a sodium benzoate.
3, the described child ammonia phenol alkyl amine affervescent tablet preparation method of a kind of claim 1 is characterized in that processing step is: get acetaminophen, amantadine hydrochloride, caffeine, chlorphenamine maleate and be ground into fine powder, cross 100 mesh sieves; Other gets the artificial Calculus Bovis and is ground into impalpable powder, crosses 325 mesh sieves; The abundant mixing of above-mentioned powder, standby.Get the lactose of above-mentioned 1/2 medicated powder of measuring, 1/2 amount, the protein sugar and the citric acid of 1/2 amount, mixing is granulated with 5% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution, 24 mesh sieves, and is dry below 60 ℃, gets granulates; Other gets remaining above-mentioned medicated powder, lactose, protein sugar and sodium bicarbonate, mixing, granulate with 5% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution, 24 mesh sieves, dry below 60 ℃, spray into essence, get the alkali granule, get above-mentioned granulates and alkali granule, the adding sodium benzoate is an amount of, 24 mesh sieve granulate, mixing is pressed into 1000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101205211A CN1823843A (en) | 2005-12-23 | 2005-12-23 | Child ammonia phenol alkyl amine affervescent tablet and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101205211A CN1823843A (en) | 2005-12-23 | 2005-12-23 | Child ammonia phenol alkyl amine affervescent tablet and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1823843A true CN1823843A (en) | 2006-08-30 |
Family
ID=36934783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005101205211A Pending CN1823843A (en) | 2005-12-23 | 2005-12-23 | Child ammonia phenol alkyl amine affervescent tablet and its preparation method |
Country Status (1)
| Country | Link |
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| CN (1) | CN1823843A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102879517A (en) * | 2012-10-08 | 2013-01-16 | 葵花药业集团(衡水)得菲尔有限公司 | Quality testing method for compound paracetamol and amantadine hydrochloride granules |
| CN103564593A (en) * | 2012-08-02 | 2014-02-12 | 佳格食品股份有限公司 | Effervescent tablets with enhanced refreshing effect |
| CN104041908A (en) * | 2014-07-02 | 2014-09-17 | 菏泽尧舜牡丹生物科技有限公司 | Preparation method of peony pollen effervescent tablet |
| CN115300468A (en) * | 2022-08-08 | 2022-11-08 | 广西纯正堂制药有限公司 | Pediatric paracetamol, atificial cow-bezoar and chlorphenamine maleate orally disintegrating tablets and preparation method thereof |
-
2005
- 2005-12-23 CN CNA2005101205211A patent/CN1823843A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103564593A (en) * | 2012-08-02 | 2014-02-12 | 佳格食品股份有限公司 | Effervescent tablets with enhanced refreshing effect |
| CN105412041A (en) * | 2012-08-02 | 2016-03-23 | 佳格食品股份有限公司 | Effervescent tablet with energizing enhancing effect |
| CN102879517A (en) * | 2012-10-08 | 2013-01-16 | 葵花药业集团(衡水)得菲尔有限公司 | Quality testing method for compound paracetamol and amantadine hydrochloride granules |
| CN104041908A (en) * | 2014-07-02 | 2014-09-17 | 菏泽尧舜牡丹生物科技有限公司 | Preparation method of peony pollen effervescent tablet |
| CN115300468A (en) * | 2022-08-08 | 2022-11-08 | 广西纯正堂制药有限公司 | Pediatric paracetamol, atificial cow-bezoar and chlorphenamine maleate orally disintegrating tablets and preparation method thereof |
| CN115300468B (en) * | 2022-08-08 | 2024-01-30 | 广西纯正堂制药有限公司 | Pediatric paracetamol, chlorphenamine maleate orally disintegrating tablet and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20060830 |