CN1823840A - Medicine and food dual purpose nutritive product for preventing and treating nightblindness and its manufacturing method - Google Patents
Medicine and food dual purpose nutritive product for preventing and treating nightblindness and its manufacturing method Download PDFInfo
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- CN1823840A CN1823840A CN 200510136572 CN200510136572A CN1823840A CN 1823840 A CN1823840 A CN 1823840A CN 200510136572 CN200510136572 CN 200510136572 CN 200510136572 A CN200510136572 A CN 200510136572A CN 1823840 A CN1823840 A CN 1823840A
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Abstract
A Western medicine used as both medicine and food for preventing and treating nyctalope is prepared from vitamins, trace elements and Ca. Its preparing process is also disclosed.
Description
The eyes are the windows of the mind, occupy first of the face, everybody thirsts for having a pair of healthy eye and good vision, but whole world nearly half people suffers from variety classes and ophthalmic in various degree, wherein more than 4,000 ten thousand people are blind, as not adopting an effective measure, the crowd who encroached on by ophthalmic will be doubled and redoubled, ophthalmic will threaten everyone.Therefore, prevention of blindness, effectively controlling ophthalmic infringement, is one of human challenge that faces in 21 century.China of new century need a large amount of high-quality talents, body and mind especially eye health be the basis, but China youngsters and children student's physical health situation is troubling at present, the vision health problem is outstanding especially.Show that according to national students in middle and primary schools' myopic eye preventing and treating work sampling monitoring result in 1999 national pupil's poor eyesight rate is 18.57%, rate of myopia is 13.35%; Junior school student's poor eyesight rate is 45.04%, and rate of myopia is 37.44%; High school student's poor eyesight rate is 67.29%, and rate of myopia is 61.5%; Nyctalopia to the sensitivity of the low light level reduce, especially big and frequent easily the looking naturally of conversion of the power contrast of light closely causes myopia, also has a strong impact on many nights, low light level sex work safety such as nighttime driving etc., becomes the problem that the whole society generally is concerned about.How effectively to reduce the rate of myopia of youngsters and children, the control ophthalmic stops the development trend of bad vision in youngsters and children and all groups to the infringement of vision, becomes the problem that the whole society generally is concerned about.What " Sight first China Act " was that Ministry of Public Health and China Disabled Federation etc. carry out both at home and abroad hand in hand is the large-scale international cooperative project of main task and target with prevention and health care and curing cataract, has obtained remarkable achievement since the execution.This project is implemented the policy of putting prevention first from start to finish, with outreach eye care and prevention of blindness knowledge, improves eye care consciousness, as the important content of this action; The Ministry of Education, Ministry of Public Health, SARFT(The State Administration of Radio and Television), the Central Committee of the Communist Young League and China Disabled Persons' Federation's joint signature file in 2000, the education of disease prevention and health protection activity of " cherishing our eyes " of national teenager is carried out in decision in " Sight first China Act ".
In recent years, improvement because of the living condition, many children even comprise that a large amount of adults have the custom of monophagia, as have a sweet tooth and rich food dish, do not eat vegetable or edible variety and amount very little, and various vegetables are above-mentioned nutrient substance main sources, so that the nutrient substance that even if the long-term above-mentioned not monophagia of famine also very easily lacks in the body, and these nutrient substance are very important to improving whole body premunition level and ability, must influence eye health and vision level and progressively increase the weight of the state of an illness.True as this, just be enough to make us startling as above-mentioned national students in middle and primary schools' myopic eye preventing and treating work sampling monitoring result, this also does not comprise adult data yet! What change is exactly " custom " and the well-known people of being are the most difficult, the Chinese idiom maxim that this just has " rivers and mountains easily changes, nature difficulty move " is therefore look to changing deviation food habit by all crowds especially child comprehensively and is reached balanced nutritious purpose of preventing and treating ophthalmic and vision care huge, its probability of difficulty, feasibility and operability are obviously all unrealistic undoubtedly.
The present invention is exactly for solving this difficult problem and giving that above-mentioned Sight first China Act activity provides more, the medicine-food two-purpose Western medicine that designs of operability and embodiment is prevented and treated the nyctalopia nutrient product widely, product does not have crowd restriction, to pre-myopia prevention, improve eyes and the vision health situation has the practical value of particular importance and positive now and far-reaching significance.Be to strengthen the understanding of the present invention, the main scientific and technological principle and the innovation that below continue to introduce the present invention and foundation thereof are advantage.
Reasonably nutrient substance not only promotes teenager health normal growth to grow and to improve premunition such as booster immunization proteic synthetic etc., also is the Fundamentals of safeguarding eye health, prevention and the various oculopathy of treatment simultaneously, complements each other between them, promotes mutually.Nutritional imbalance, deficiency or superfluous, body interior all can go wrong.For preventing and treating ophthalmic such as nyctalopia, following health promulgated by the ministries or commissions of the Central Government and GB2760 and GB14880 officinal food dual purpose product and function becomes more important and outstanding, spy further are described below one by one:
Vitamin A can be prevented and treated nyctalopia, conjunctival xerosis and keratomalacia: nyctalopia is exactly in night or the dark phenomenon of locating cannot see thing.Nyctalopia has two types, and a kind of is that the people of congenital night blindness, most of congenital night blindnesses is just blind after 40-50 year, and this nyctalopia does not also have effective Therapeutic Method at present.Another kind is the acquired night blindness of vitamin A deficiency.The people is at the dark place or see thing night, what lean on is rod cell on the retina, because containing, rod cell inside experiences material---the rhodopsin that the low light level stimulates, and one of primary raw material of synthetic rhodopsin is a vitamin A, so be understood that, if be deficient in vitamin in the diet A or gastrointestinal tract can not absorb vitamin A, cause rod cell not synthesize or synthetic rhodopsin not enough and cause nyctalopia, if in time replenish intravital vitamin A, acquired night blindness just can very fast healing; Vitamin A is to keep all epithelial tissue to perfect necessary nutrient substance, during shortage, epithelium drying, hypertrophy and keratinization are wherein influenced remarkable with the epithelium of eye etc.Because epithelial tissue is unsound, the ability of body opposing microbiological attack reduces, and catches easily; Because the lachrymal gland epithelium is unsound, secretion stops, so easily produce xerophthalmia; So vitamin A claims antixerophthalmic vitamin again.The symptom of xerophthalmia is cornea and conjunctival xerosis, inflammation, even keratomalacia and boring a hole.β-Hu square-bottomed bamboo basket Bu Su not only can change into vitamin A, again do not have the toxicity of VA and can accumulate in vivo and to the people harmless (as accumulate too much also only show skin slightly yellowing that is all, need only short-term stop using and can recover the former colour of skin rapidly), so the present invention is with its alternative part of V A, and when lacking, VA transforms rapidly with compensation VA, so tool regulate supplies double effects automatically.The bone in children abnormal development of vitamin D deficiency can cause narrow, the exophthalmos of a frame, causes ametropia.Vitamin B
1Lack and cause conjunctiva and corneal epithelium infringement causing xerophthalmia, retrobulbar neuritis, optic atrophy.Vitamin B
2Lack and to cause eyes many places inflammation such as keratitis (blood vessel hyperplasia, muddiness, fester), conjunctivitis, iritis, optic neuritis, scleral injection, even crystalline lens and vitreous opacity occur.Vitamin PP (nicotinic acid is that nicotinic acid and niacin amide are nicotiamide) lacks and causes neural malnutrition and neuritis, makes optic atrophy.Hypovitaminosis C cause intercellular substance such as collagen protein synthetic generation obstacle, wound appears and ulcer is difficult for healing; Capillary permeability increases, cause vitamin C deficiency such as subcutaneous, mucosa, hemorrhage of muscle, so can bring out eyeball and the accessory organs of eye official is hemorrhage, as serious consequences such as subretinal choroidal hemorrhage will cause losing one's sight, also can influence the healing of eye inflammation, macular hole etc.(it is a lot of that nucleic acid contains chromium for mineral calcium (bone strengthening) and trace element chromium, nucleic acid lacks and causes comprising that the normal growth of eyes and function are suppressed, chromium deficiency also causes insulin active low, concurrent hyperglycemia and the glycosuria on an empty stomach of comprising, because of energy shortage makes premunition that various ophthalmics lowly easily take place and looks disease, comprise also that wherein hyperglycemia causes energy to supply with lowly or digest and assimilate bad cause energy and the insufficient direct harm of other nutrients, as the huge retina that consumes energy is because of energy, the nutrition especially insufficient function degeneration of VA causes nyctalopia, serious reduction vision and blinding pathological changes such as myopia also is on the rise with extensive, especially old people Geng Yi lacks chromium, should pay much attention to especially) lack wall of eyeball elasticity is weakened, eye frame and optical fundus framework deformation and eye (looking) axle is elongated myopia takes place, and can not increase atrophy because of retina and choroid, be elongated, distortion, attenuation, finally cause retina to be pulled open and split formation macular hole (stating as follows), or choroidal rupture is hemorrhage cause losing one's sight (seeing above-mentioned), not only cause and deepen true myopia, vitreous opacity and liquefaction are shunk and cause also being pulled open and split and form macular hole by its retina that involves, grievous injury patient central vision dwindles as looking thing, distortion, even central vision complete obiteration, make many occupations that must rely on central vision and work as drive (because of central light loss can't be seen traffic signal, or because of image replacement or covering around the center image quilt, central vision is seen be in fact peripheral image be false center image and very easily lead to serious traffic safety accident), read and (seriously dwindle distortion, even cannot see any literal or the image of being watched attentively at all, all the other are identical with above-mentioned driving situation) etc. can't carry out at all, the vitreous humor of liquefaction that What is more leaks under the disruptive retina and constantly and enlarges, cause retina part even come off fully, as give treatment to untimely then blinding fully.Trace element-selenium is the same with vitamin C to be activated plurality of enzymes and enzyme system and is beneficial to element and vitamin Bs such as calcium (as the acidity of VC), chromium
1And vitamin B
2With the absorbing and bring into play effect, and strengthen effect mutually, of vitamin PP etc. as vitamin B
1Lack and cause vitamin B
2Output, increase, make the vitamin B in the in-vivo tissue in the urine
2Descend, vitimin supplement PP has prevented again because of vitimin supplement B
1The shortage of aggravation vitamin PP, thereby make vitamin B group dosage keep balance etc., make energy supply abundance, ensure VA (power consumption) conversion and the movable required big energy of retina and improve their vigor and function, improvement to nyctalopia and vision all has very great help mutually, so the helpfulness degree of association is very high.
Product of the present invention is made up of legal dietotherapeutic compound vitamin 1-3 part, compound microelement 0.01-0.1 part, calcium preparation 1-3 part; Wherein:
Compound vitamin is by vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part are formed;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
Compound calcium preparation is made up of calcium gluconate 3-5 part and calcium citrate 3-5 part;
Above material adopts other kind of GB2760 and GB14880 approval to convert consumption by active substance.
The manufacture method of product of the present invention is as follows:
The preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
The preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
The preparation of product of the present invention: in sterilizing room, get compound vitamin 1-3 part, compound microelement 0.01-0.1 part, calcium preparation 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; With Any shape such as raw produce 3-5 part of the present invention and 1-3 part lactose mixing, the sheet that is pressed into the 0.2-0.4 gram, grain, balls, get product.
The purposes of product of the present invention, usage and consumption: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
Embodiment:
In sterilizing room, get 2 parts of compound vitamines, 0.03 part of compound microelement, 3 parts of calcium preparation, join and ground well in the nonmetal mortar 3-5 minute, raw produce; With 3 parts of raw produce of the present invention and Any shape such as 1 part of mixing of lactose, the sheet that is pressed into the 0.2-0.4 gram, grain, ball, must product.
Supplementary copy inventive principle and advantage are as follows:
1, the present invention adopts the low lactose of water absorption to do complexion changed and easy preservation that filler can reduce duration of storage, so storage life is that the commodity shelf life is long, economic worth is high; And form particularly favourite " acid is sour-sweet sweet " the popular taste products of children and easily being accepted of most crowds jointly with the acescency of the low sweet taste of lactose and calcium gluconate and calcium citrate, so service face and service group are the most extensive, its society and economic benefit are also just apparent naturally, and these also are the great novelty and the practicality of the legal approval of Patent Law.
2, medicine variety and function all are legal medicine-food two-purposes and simple and clear and do not have a dispute, the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer.
3, all medical materials all are conventional varieties and have no side effect, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.
4, become the favorable factor of the defective of China and Asia average 80% above population Lactose enzyme indigestibility absorption for want of (as milk) lactose into disease preventing and treating, because adopt lactose to replace the starch of easily digesting and assimilating and dextrin is made adsorbent and filler can significantly slow down the medicine slow release speed, thereby significantly prolong the efficacy of a drug persistent period and improve curative effect and possible medicine irritation is relieved to bottom line.
Test method, data and presentation of results and prompting:
Disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, experimenter's voluntary participation.Product of the present invention because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, make test be easy to just satisfactorily be finished, now relevant situation is allowed to keep in Patent Law and further is explained as follows (only for reference) under the prerequisite of necessary KNOW-HOW and business secret and also please understands.It is 2 groups that totally 40 of the test patients at different sexes, age, 20 people are divided into for one group: wherein one group with product of the present invention and usage and dosage prevent and treat nyctalopia, another is organized not medication and compares; Test period 2 months; Test number and duration of test runs tool statistical significance are so have suitable representativeness and credibility.The result is as follows: the experimenter only has 3 people to find that nyctalopia does not have with the test group personnel of product of the present invention to improve but none routine nyctalopia degree increases, and all the other night visions and low light level eyesight improving, goes up not down; The matched group experimenter finds that nyctalopia and visual deterioration degree increase the weight of 12 people, 8 people's no changes, none eyesight improving, the person of going up not down.
Prompting: it is that no change itself just belongs to effectively (control and stablized the state of an illness) that nyctalopia and myopia, the state of an illness are not deepened, and night vision and low light level eyesight improving, goes up not down and number illustrates that effect is remarkable.
Claims (3)
1, the medicine-food two-purpose Western medicine is prevented and treated the nyctalopia nutrient product, is made up of dietotherapeutic compound vitamin 1-3 part, compound microelement 0.01-0.1 part, calcium preparation 1-3 part; Wherein:
Compound vitamin is by vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part are formed;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
Compound calcium preparation is made up of calcium gluconate 3-5 part and calcium citrate 3-5 part;
Above material adopts other kind of GB2760 and GB14880 approval to convert consumption by active substance.
2, to prevent and treat the manufacture method of nyctalopia nutrient product as follows for the medicine-food two-purpose Western medicine:
A. the preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
B. the preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
C. the medicine-food two-purpose Western medicine is prevented and treated the preparation of nyctalopia nutrient product: in sterilizing room, get compound vitamin 1-3 part, compound microelement 0.01-0.1 part, calcium preparation 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; With raw produce 3-5 part of the present invention and 1-3 part lactose mixing, be pressed into sheet, grain, the ball of 0.2-0.4 gram, must product.
3, the medicine-food two-purpose Western medicine is prevented and treated the purposes of nyctalopia nutrient product: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
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| CN 200510136572 CN100553642C (en) | 2005-12-29 | 2005-12-29 | The medicine-food two-purpose Western medicine is prevented and treated nyctalopia nutrient product and manufacture method |
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| CN 200510136572 CN100553642C (en) | 2005-12-29 | 2005-12-29 | The medicine-food two-purpose Western medicine is prevented and treated nyctalopia nutrient product and manufacture method |
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| CN1823840A true CN1823840A (en) | 2006-08-30 |
| CN100553642C CN100553642C (en) | 2009-10-28 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376252C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose compound vitamin microelement mineral nutritive product for preventing true myopia and its manufacturing method |
| CN100376241C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose product for preventing true myopia and its manufacturing method |
| CN100376238C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose nutritive product for preventing pseudomyopia and real myopia and its manufacturing method |
| CN100376237C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Vitamin micro element mineral calcium nutritive product for preventing pseudomyopia and roal myopia and its manufacturing method |
-
2005
- 2005-12-29 CN CN 200510136572 patent/CN100553642C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376252C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose compound vitamin microelement mineral nutritive product for preventing true myopia and its manufacturing method |
| CN100376241C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose product for preventing true myopia and its manufacturing method |
| CN100376238C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose nutritive product for preventing pseudomyopia and real myopia and its manufacturing method |
| CN100376237C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Vitamin micro element mineral calcium nutritive product for preventing pseudomyopia and roal myopia and its manufacturing method |
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| Publication number | Publication date |
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| CN100553642C (en) | 2009-10-28 |
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Address after: No. two, section 17, West Ring Road, Chengdu, Sichuan Patentee after: Yan Huaiwei Address before: Jili Industrial Zone, national hi tech Zone, Chancheng District, Foshan, Guangdong Patentee before: Yan Huaiwei |
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Granted publication date: 20091028 Termination date: 20100129 |