CN1818635A - THz inspection and fingerprint spectrum for 12 drugs - Google Patents
THz inspection and fingerprint spectrum for 12 drugs Download PDFInfo
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- CN1818635A CN1818635A CN 200610065743 CN200610065743A CN1818635A CN 1818635 A CN1818635 A CN 1818635A CN 200610065743 CN200610065743 CN 200610065743 CN 200610065743 A CN200610065743 A CN 200610065743A CN 1818635 A CN1818635 A CN 1818635A
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Abstract
A method for detecting twelve types of narcotic drugs by utilizing TH2 technique includes preparing narcotic drugs standard sample; applying TH2 detection technique to carry out detection on said standard samples and setting up standard fingerprint chart bank; utilizing standard set-up fingerprint chart bank to carry out detection on unknown matter including six types of morphine narcotic drugs, three types of ice narcotic drugs, two types of drugs controlled by the state and one type of new narcotic drugs.
Description
Technical field
The present invention relates to the detection method and the dactylogram thereof of 12 kinds of drugs, 12 kinds of drugs are meant: Heroinhydrochloride, morphine hydrochloride, acetyl codeine, codeine phosphate, sulfaminic acid O
3Monoacetylmorphine, hydrochloric acid O
6Monoacetylmorphine, Methamphetaminium Chloride, hydrochloric acid MDA, hydrochloric acid MDMA, caffeine hydrochloride, ephedrine hydrochloride, ketalar belong to drugs detection technique field.
Background technology
At present, be used to identify that the method for drug species and content mainly contains: chromatographic process, capillary electrophoresis method, mass spectrometry method and fourier infrared absorption spectra method.A common ground of these methods is exactly, and they all belong to and diminish detection, i.e. checking matter damage thereupon after having inspected.Diminishing detection has a very big problem for the discriminating of drugs, because the weight of drugs and percentage composition are very important reference index when punishment fits the crime, not only total amount must not arbitrarily reduce but also require the percentage composition can replication.
In addition, the method that drugs detect, identification is adopted also has the X-ray scanning method.X-ray scanning can only be told the shape of drugs, can not determine out the kind of drugs, and because its energy is high especially, makes drug numerator generation ionization easily, thereby influence the analysis of drugs.
Because the THz technology is nearly ten or twenty new developing technology just in the world over year, the research that utilizes the THz technology to survey drugs is among the fast development.
Summary of the invention
The objective of the invention is to propose a kind of THz detection method and dactylogram thereof of 12 kinds of drugs, make up 12 kinds of drugs fingerprint spectrum libraries and utilize whether fingerprint spectrum library can the fast detecting unknown material be the kind of drugs and drugs by using the THz detection technique, and be Non-Destructive Testing.
The THz detection method of 12 kinds of drugs comprises the steps:
1. prepare the drugs standard model;
2. use the THz detection technique drugs standard model is detected and make up the standard fingerprint spectrum library;
3. utilize the standard fingerprint spectrum library that makes up that unknown material is detected;
When it is characterized in that preparing the drugs standard model, the preparation method of 12 kinds of drugs standard models is identical, all is the drugs of purity more than 90% to be ground the back evenly mix with polyethylene powders.
In addition, when preparation drugs standard model, preferred scheme is: the weight ratio of drugs and polyethylene powders is 1: 5, simultaneously the drugs standard model is pressed into sheet form.
When detection drugs standard model made up its standard finger-print, preferred test environment was under the condition of nitrogen gas, and air humidity is less than 4.7%, and temperature is at 21 ℃.
The technical solution used in the present invention is respectively 12 kinds of drugs to be measured by the THz time-domain spectroscopic technology, obtained the THz time-domain spectroscopy of 12 kinds of drugs, obtain their frequency domain spectrum again by Fourier transform, utilize relevant data processor then, obtain the THz fingerprint absorption spectrum of 12 kinds of drugs in 0.2～2.6THz frequency range.12 kinds of drugs comprise 6 kinds of drugs such as morphine, Heroinhydrochloride, morphine hydrochloride, acetyl codeine, codeine phosphate, sulfaminic acid O
3Monoacetylmorphine and hydrochloric acid O
6Monoacetylmorphine, 3 kinds of methamphetamine class drugs, Methamphetaminium Chloride, hydrochloric acid MDA and hydrochloric acid MDMA, 2 kinds of national control similar drugs, caffeine hydrochloride and ephedrine hydrochloride, a kind of emerging drugs, ketalar.Theoretical and experimental study shows that all the THz ripple is in the fingerprint spectral coverage of drugs, the absorption peak of THz and the vibration of molecule or rotational energy level are corresponding, each drugs all has the characteristic absorption spectrum relevant with its molecular structure, in 0.2～2.6THz frequency range, each drugs all has a plurality of characteristic absorption peaks, the peak position difference of different cultivars, the peak position of same kind are not in time, environment, sample state change.Therefore, the drugs THz spectrum experiment data that obtain as stated above are exactly the drugs dactylogram of this wave band, have set up standard dactylogram database according to this, as the scale of differentiating unknown drugs.
Use above-mentioned dactylogram database,, the kind of drugs to be measured can be decided fast by discerning the dactylogram position of unknown drugs to be measured.The recognition methods of being adopted comprises that spectrum directly compares artificial cognition, artificial neural network, space pattern analysis of components etc.
Compare with infrared waves, millimeter wave and X ray, when utilizing the THz ripple to detect drugs, because the THz ripple is in the fingerprint spectral coverage of drugs, the absorption peak of THz and the vibration of molecule or rotational energy level are corresponding.It is that the THz electromagnetic wave has very strong penetration power that this kind method has made full use of the electromagnetic peculiar property of THz, and it can pass non-polar materials such as plastics, carton, clothing, thereby can realize non-contact detecting.Trace detection of the prior art has only when detected drugs have vestige to be exposed to the outside and reach a certain amount of, could effectively it be detected, so have bigger limitation.The present invention can overcome the deficiency of trace detection method, the drugs in the airtight non-polar material is made accurately identify.
Because the electromagnetic single photon energy of THz is very low, the energy of 1THz correspondence has only 4.1meV, detects the composition that drugs can not destroy detected material so use the THz ripple, can realize Non-Destructive Testing.
Description of drawings
Fig. 1: THz time-domain spectroscopy detection system synoptic diagram, wherein 4 is InAs crystal as emitter, 6 is as the ZnTe crystal of surveying the utmost point, 3 is chopper, and 2 is beam splitter, and 1 is 1/2nd wave plates, 7 is quarter-wave plate, and M1～M13 is a catoptron, and PM1～PM4 is an off axis paraboloidal mirror, L1～L3 is a condenser lens, 9 is polarizer, and D1～D4 is a diaphragm, and 8 is Wollaston prism, 5 can transmission THz ripple and reflect femtosecond laser for silicon chip, and 10 are connected to lock-in amplifier for detector.
Fig. 2: the THz finger-print of Heroinhydrochloride;
Fig. 3: the THz finger-print of morphine hydrochloride;
Fig. 4: the THz finger-print of acetyl codeine;
Fig. 5: the THz finger-print of codeine phosphate;
Fig. 6: sulfaminic acid O
3The THz finger-print of monoacetylmorphine;
Fig. 7: hydrochloric acid O
6The THz finger-print of monoacetylmorphine;
Fig. 8: the THz finger-print of Methamphetaminium Chloride;
Fig. 9: the THz finger-print of hydrochloric acid MDA;
Figure 10: the THz finger-print of hydrochloric acid MDMA;
Figure 11: the THz finger-print of caffeine hydrochloride;
Figure 12: the THz finger-print of ephedrine hydrochloride;
Figure 13: the THz finger-print of ketalar.
Embodiment
The THz detection method of 12 kinds of drugs realizes on THz time-domain spectroscopy detection system, with reference to Fig. 1, the femtosecond laser that laser instrument produces passes through mirror M 1 successively, diaphragm 1 and beam splitter 2, behind process beam splitter 2, femtosecond laser is divided into two-beam, a branch of light of transmission is pretended and is pump light, it is through chopper 3, diaphragm D2, mirror M 2～M5, diaphragm D3～D4, incide behind the condenser lens L1 on the transmitting crystal 4 (InAs＜100 〉), produce the THz ripple by the optical rectification effect, the THz ripple passes through paraboloidal mirror PM1～PM4 again, focuses on the crystal detection 6 (ZnTe＜110 〉) at paraboloidal mirror PM4 focus place.A branch of light of reflection is as surveying light, it is through a series of mirror M 6～M11, one condenser lens L2 is arranged between M9 and M10, reflex to the focus point of THz ripple on the crystal detection 6 then by silicon chip 5 through polarizer 9, method by electro-optic sampling is surveyed, and by quarter-wave plate 7, is divided into the orthogonal two-beam in polarization direction by Wollaston prism 8 at last, connect lock-in amplifier by a photodetector 10, carry out data acquisition by computing machine.Sample places on the specimen holder at paraboloidal mirror PM2 and paraboloidal mirror PM3 focus place during experiment, and the information when THz just can carry sample during by sample just can extract relevant information by data processing.
With Heroinhydrochloride (hereinafter to be referred as drugs 1) is example.
The standard model that at first prepares drugs 1 grinds the back with the drugs 1 of purity more than 90% and evenly mixes with polyethylene powders, and drugs 1 were controlled at 1: 5 with the weight ratio of polyethylene powders.Utilize infrared sheeter to carry out compressing tablet with 5 tons pressure then, make diameter 1.3cm, thickness is the thin rounded flakes of 1mm.The purpose of mixing PEF is that PEF can play effects bonding and the dilution drugs, and experiment is verified, and PEF does not absorb the electromagnetic wave of THz wave band substantially, can the absorption spectra of preparation sample not exerted an influence.
With reference to Fig. 1, in THz time-domain spectroscopy detection system, specimen holder is positioned at the focus place of paraboloidal mirror PM2 and paraboloidal mirror PM3, and drugs 1 standard model for preparing is positioned on the specimen holder, by THz time-domain spectroscopy detection technique drugs 1 is measured.Dotted portion places nitrogen environment among Fig. 1 when experiment measuring, and air humidity is less than 4.7%, and temperature is 21 ℃.At first obtain the THz time-domain spectroscopy of drugs 1, obtain its frequency domain spectrum by Fourier transform again, utilize relevant frequently-used data handling procedure then, obtain the THz fingerprint absorption spectrum of drugs 1 standard model in 0.2～2.6THz frequency range, the standard dactylogram sees Fig. 2 for details.
With reference to the method that makes up drugs 1 standard model finger-print, set up morphine hydrochloride, acetyl codeine, codeine phosphate, sulfaminic acid O more successively
3Monoacetylmorphine, hydrochloric acid O
6Monoacetylmorphine, Methamphetaminium Chloride, hydrochloric acid MDA, hydrochloric acid MDMA, caffeine hydrochloride, ephedrine hydrochloride, ketalar be the THz finger-print of totally ten one kinds of drugs standard models.The THz finger-print of these 11 kinds of drugs standard models is successively referring to Fig. 3 to Figure 13.Behind the finger-print that builds 12 kinds of drugs standard models, just can utilize the detection of the finger-print realization of THz time-domain spectroscopy detection system and 12 kinds of drugs standard models to unknown measured object.
Claims (7)
1. the THz detection method of 12 kinds of drugs comprises the steps:
1) preparation drugs standard model;
2) use the THz detection technique drugs standard model is detected and make up the standard fingerprint spectrum library;
3) utilize the standard fingerprint spectrum library that makes up that unknown material is detected;
Described 12 kinds of drugs are meant: Heroinhydrochloride, morphine hydrochloride, acetyl codeine, codeine phosphate, sulfaminic acid O
3Monoacetylmorphine, hydrochloric acid O
6Monoacetylmorphine, Methamphetaminium Chloride, hydrochloric acid MDA, hydrochloric acid MDMA, caffeine hydrochloride, ephedrine hydrochloride, ketalar,
When it is characterized in that preparing the drugs standard model, the preparation method of 12 kinds of drugs standard models is identical, all is the drugs of purity more than 90% to be ground the back evenly mix with polyethylene powders.
2. the THz detection method of 12 kinds of drugs according to claim 1, the weight ratio that it is characterized in that drugs and polyethylene powders is 1: 5.
3. the THz detection method of 12 kinds of drugs according to claim 1 is characterized in that the drugs standard model is made the form of sheet.
4. the THz detection method of 12 kinds of drugs according to claim 1, the weight ratio that it is characterized in that drugs and polyethylene powders is 1: 5, simultaneously the drugs standard model is made the form of sheet.
5. according to the THz detection method of claim 1 or 2 or 3 or 4 described 12 kinds of drugs, it is characterized in that test environment is under the condition of nitrogen gas when detecting the drugs standard model, air humidity is less than 4.7%, and temperature is at 21 ℃.
6. the THz detection method of 12 kinds of drugs according to claim 5, it is characterized in that utilizing the THz finger-print of 12 kinds of drugs standard models that this detection method makes up, according to Heroinhydrochloride, morphine hydrochloride, acetyl codeine, codeine phosphate, sulfaminic acid O
3Monoacetylmorphine, hydrochloric acid O
6The order of monoacetylmorphine, Methamphetaminium Chloride, hydrochloric acid MDA, hydrochloric acid MDMA, caffeine hydrochloride, ephedrine hydrochloride, ketalar, as accompanying drawing 2 to shown in the accompanying drawing 13.
7. the THz detection method of 12 kinds of drugs according to claim 5 is characterized in that the frequency range of the THz fingerprint absorption spectrum of 12 kinds of drugs is 0.2～2.6THz.
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Cited By (13)
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| CN101832940A (en) * | 2010-03-16 | 2010-09-15 | 首都师范大学 | Terahertz polarization real-time imaging method |
| CN101975754A (en) * | 2010-09-26 | 2011-02-16 | 首都师范大学 | Reflective terahertz spectral analysis method capable of eliminating phase error |
| CN102012361A (en) * | 2010-09-26 | 2011-04-13 | 首都师范大学 | Reflection type terahertz spectrum analysis method for eliminating phase error |
| CN102565260A (en) * | 2011-12-20 | 2012-07-11 | 公安部禁毒情报技术中心 | Method for preparing diacetylmorphine hydrochloride standard substance |
| CN101556280B (en) * | 2009-05-20 | 2013-04-24 | 江西中德生物工程有限公司 | Immunochromatography detection card for detecting fluorescent microspheres of ketamine and methyl amphetamine and preparation method thereof |
| CN104251838A (en) * | 2014-08-27 | 2014-12-31 | 北京环境特性研究所 | Forbidden object detection method and device |
| CN104316487A (en) * | 2014-09-19 | 2015-01-28 | 北京环境特性研究所 | Forbidden objects detection method and device |
| CN104392084A (en) * | 2014-08-27 | 2015-03-04 | 北京环境特性研究所 | Standard substance characteristic-database establishing method and device on basis of terahertz frequency band |
| CN104251838B (en) * | 2014-08-27 | 2017-01-04 | 北京环境特性研究所 | Prohibited items detection method and device |
| CN107064376A (en) * | 2016-12-23 | 2017-08-18 | 东北制药集团沈阳第制药有限公司 | A kind of method of pseudomorphine content in detection opium tincture |
| CN108226088A (en) * | 2017-12-30 | 2018-06-29 | 雄安华讯方舟科技有限公司 | A kind of drug test method and device |
| CN109946749A (en) * | 2019-03-27 | 2019-06-28 | 嘉兴腓特烈太赫科技有限公司 | Detect the device of internal drugs |
| CN110823831A (en) * | 2019-11-18 | 2020-02-21 | 上海应用技术大学 | Far infrared detection method for drugs |
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101556280B (en) * | 2009-05-20 | 2013-04-24 | 江西中德生物工程有限公司 | Immunochromatography detection card for detecting fluorescent microspheres of ketamine and methyl amphetamine and preparation method thereof |
| CN101832940B (en) * | 2010-03-16 | 2012-07-25 | 首都师范大学 | Terahertz polarization real-time imaging method |
| CN101832940A (en) * | 2010-03-16 | 2010-09-15 | 首都师范大学 | Terahertz polarization real-time imaging method |
| CN101975754A (en) * | 2010-09-26 | 2011-02-16 | 首都师范大学 | Reflective terahertz spectral analysis method capable of eliminating phase error |
| CN102012361A (en) * | 2010-09-26 | 2011-04-13 | 首都师范大学 | Reflection type terahertz spectrum analysis method for eliminating phase error |
| CN102565260A (en) * | 2011-12-20 | 2012-07-11 | 公安部禁毒情报技术中心 | Method for preparing diacetylmorphine hydrochloride standard substance |
| CN102565260B (en) * | 2011-12-20 | 2014-07-30 | 公安部禁毒情报技术中心 | Method for preparing diacetylmorphine hydrochloride standard substance |
| CN104251838B (en) * | 2014-08-27 | 2017-01-04 | 北京环境特性研究所 | Prohibited items detection method and device |
| CN104251838A (en) * | 2014-08-27 | 2014-12-31 | 北京环境特性研究所 | Forbidden object detection method and device |
| CN104392084A (en) * | 2014-08-27 | 2015-03-04 | 北京环境特性研究所 | Standard substance characteristic-database establishing method and device on basis of terahertz frequency band |
| CN104316487A (en) * | 2014-09-19 | 2015-01-28 | 北京环境特性研究所 | Forbidden objects detection method and device |
| CN107064376A (en) * | 2016-12-23 | 2017-08-18 | 东北制药集团沈阳第制药有限公司 | A kind of method of pseudomorphine content in detection opium tincture |
| CN107064376B (en) * | 2016-12-23 | 2019-05-21 | 东北制药集团沈阳第一制药有限公司 | A kind of method of pseudomorphine content in detection opium tincture |
| CN108226088A (en) * | 2017-12-30 | 2018-06-29 | 雄安华讯方舟科技有限公司 | A kind of drug test method and device |
| WO2019127962A1 (en) * | 2017-12-30 | 2019-07-04 | 雄安华讯方舟科技有限公司 | Drug inspection method and apparatus |
| CN109946749A (en) * | 2019-03-27 | 2019-06-28 | 嘉兴腓特烈太赫科技有限公司 | Detect the device of internal drugs |
| CN110823831A (en) * | 2019-11-18 | 2020-02-21 | 上海应用技术大学 | Far infrared detection method for drugs |
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