CN1814196B - Chinese medicine composition for treating functional metrorrhagia and preparation method thereof - Google Patents
Chinese medicine composition for treating functional metrorrhagia and preparation method thereof Download PDFInfo
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- CN1814196B CN1814196B CN2005100618147A CN200510061814A CN1814196B CN 1814196 B CN1814196 B CN 1814196B CN 2005100618147 A CN2005100618147 A CN 2005100618147A CN 200510061814 A CN200510061814 A CN 200510061814A CN 1814196 B CN1814196 B CN 1814196B
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Abstract
The invention discloses a Chinese medicinal combination for curing functional metrorrhagia and a preparation method thereof. The Chinese medicinal combination is composed of water extract of the following raw materials and pharmaceutically acceptable additives, the weight parts of each raw material being: 300-600 parts of Radix Astragali, 300-450 parts of motherwort, 300-450 parts of Chinese angelica, 300-450 parts of rehmanniae radix, 300-450 parts of Cornus officinalis flesh, 300-450 parts of imperata rhizome, 180-300 parts of charred radix rubiae, 180-300 parts of charred paeonia suffruticosa, 120-180 parts of charred human hair. The preparation method comprises the following steps: crushing the above raw materials into a crude powder, adding water into the six tradional Chinese medicines except the charred radix rubiae, the charred paeonia suffruicosa and the charred human hair, and decocting twice, filtering, condensing the filtrate into a thick extract, drying, crushing and sieving with 100 mesh screen, adding the fine powder of the charred radix rubiae, the charred paeonia suffruitcosa and the charred human hair, mixing uniformly, moistening, softening, fetching when agglomeration, preparing the granule or tablet or capsule.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of dysfunctional uterine hemorrhage, being specifically related to a kind of is the Chinese patent medicine and the application thereof of feedstock production with Chinese medicine.
Background technology
Women's dysfunctional uterine hemorrhage belongs to the traditional Chinese medical science " metrorrhagia " category, and generally anxious with the oncoming force, amount mostly is metrorrhagia; Few or dripping unclean for leaking down with amount of bleeding, its etiology and pathogenesis does not have strict difference.Metrorrhagia is meant menstrual cycle, menstrual period, now serious disorderly through measuring, and down sudden and violent or dripping person not to the utmost was the frequently-occurring disease and the difficult disease of gynecological when menses were non-.Someone adds up, and prescription on individual diagnosis person accounts for 1/3 of gynecological's outpatient service with metrorrhagia.Modern medicine thinks that dysfunctional uterine bleeding is because the caused abnormal uterine bleeding of neuroendocrine system functional disorder is called for short " anovulatory dysfunctional uterine hemorrhage ", is one of department of obstetrics and gynecology commonly encountered diseases.Primary disease 50% betides climacteric according to statistics, and 30% betides period of duration, and 20% betides adolescence.Because the pathogenesis difference of anovulatory dysfunctional uterine hemorrhage is divided into anovulatory dysfunctional uterine hemorrhage anovulatory functional bleeding and ovulation type anovulatory dysfunctional uterine hemorrhage two big classes clinically.Anovulatory functional bleeding is the most common, accounts for about 80%, and pilosity is born in adolescence and climacteric.Many haemostatic medicament is main, and is bad as effect with hormonotherapy about the treatment doctor trained in Western medicine of anovulatory functional bleeding, can further take to perform the operation dilatation and curettage even uterectomy, and this can cause great misery to patient.
Feature of the present invention is applicable to when dysfunctional uterine hemorrhage such as menses are non-and descends that amount is many or not to the utmost dripping, and color depth is red or purplish red, and the matter thickness has been held clot under the arm, lower abdominal distention pain tenderness, symptom such as alleviation of pain under the piece.With the Radix Astragali, Radix Angelicae Sinensis, the Radix Rehmanniae, mountain Fructus Corni, Rhizoma Imperatae, Herba Leonuri, charred RADIX RUBIAE, Crinis Carbonisatus, charred CORTEX MOUTAN is component, scientific composition, processing meticulously, can QI invigorating hold up unit, cooling blood and removing stasis, blood-arresting catamenia-regulating stop the menses of metrorrhagia and metrostaxis rapidly, and clinical use has obtained satisfied effect.Therefore, effective Chinese medicine of development treatment dysfunctional uterine hemorrhage has the good application development prospect, will produce remarkable social benefit and economic benefit.
Summary of the invention
Purpose of the present invention is exactly in order to address the above problem, and providing a kind of is that the QI invigorating that has of main component is held up unit with Chinese medicine, and the effect of cooling blood and removing stasis, blood-arresting catamenia-regulating has the obvious results Chinese medicine composition to the treatment dysfunctional uterine hemorrhage.
Purpose of the present invention can take following technical scheme to realize: a kind of Chinese medicine composition for the treatment of dysfunctional uterine hemorrhage is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials:
The Radix Astragali 300～600 weight portion Herba Leonuris 300～450 weight portion Radix Angelicae Sinensis 300～450 weight portion Radix Rehmanniae 300～450 weight portion mountain Fructus Corni 300～450 weight portion Rhizoma Imperataes 300～450 weight portion charred RADIX RUBIAEs 180～300 weight portion charred CORTEX MOUTANs 180～300 weight portion Crinis Carbonisatus 120～180 weight portions
Preferable range is:
248～498 parts of 248～498 parts of Radix Angelicae Sinensis of 331～999 parts of Herba Leonuris of the Radix Astragali
166～498 parts of 166～498 parts of Rhizoma Imperataes of 166～498 parts of mountain Fructus Corni of the Radix Rehmanniae
120～180 parts of 166～498 parts of Crinis Carbonisatus of 166～98 parts of charred CORTEX MOUTANs of charred RADIX RUBIAE
Its formula optimization is:
The Radix Astragali 450 weight portion Herba Leonuris 300 weight portion Radix Angelicae Sinensis 300 weight portions
The Radix Rehmanniae 300 weight portion mountain Fructus Corni 300 weight portion Rhizoma Imperataes 250 weight portions
120 parts of charred RADIX RUBIAE 150 weight portion charred CORTEX MOUTANs 150 weight portion Crinis Carbonisatus.
Described a kind of preparation method for the treatment of the Chinese medicine composition of dysfunctional uterine hemorrhage comprises the steps:
Take by weighing each raw material by formula proportion, said medicine is pulverized ground into coarser powder, except that charred RADIX RUBIAE, charred CORTEX MOUTAN, Crinis Carbonisatus, other 6 flavor Chinese medicine decocts with water secondary, adds 8 times in water for the first time, decocts 2 hours, adds 6 times in water for the second time, decocts 1.5 hours.Filter, filtrate is condensed into thick extractum, and spissated extractum proportion is 1.20.Drying was pulverized 100 mesh sieves, added charred RADIX RUBIAE, charred CORTEX MOUTAN, Crinis Carbonisatus fine powder, mixing, moistening, soften, take out when forming agglomerate, make granule.
Purpose of the present invention can also take following method to realize:
Described pharmaceutically acceptable additives are following one or more: ethylparaben, tartaric acid, glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, dried starch citric acid, sodium bicarbonate, lecithin, sodium lauryl sulphate.
Its dosage form can be a said dosage form on any pharmaceutics, as effervescent granule electuary, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; The preferred particulates agent.
Advantage of the present invention is the metrorrhagia that this Chinese medicine composition can be used for the treatment of blood deficiency, heat in blood, blood stasis, and no matter newly of a specified duration, old, the middle-aged women of the course of disease still is that young women all has curative effect preferably.The various palace blood patients of special treatment, the deficiency and excess specimen is held concurrently and is controlled it, determined curative effect, prescription is rigorous, and is practical, is the ideal medicament that improves body of women health.
The present invention is to provide a kind of Chinese medicine composition for the treatment of dysfunctional uterine hemorrhage, for proving its therapeutic effect and safety, the granule for preparing has as stated above carried out toxicity and pharmacodynamics test, and result of study is as follows:
After the capsule mouse stomach of the present invention administration, do not find acute toxicity, mice maximum dosage-feeding on the one is 480g crude drug/kg, and 600 times of consumptions every day are equivalent to be grown up.3 months long term toxicities to rat.The result shows, with three kinds of dosage of capsule of the present invention (4,8,16g crude drug/kg), give rat continuous irrigation stomach 3 months, outside a good appetite suddenly appearing in a serious disease, heavy dose of group see that clotting time shortens, general situation, hematology, biochemistry, routine urinalysis, electrocardiogram, system's dissection, organ coefficient and histopathology to rat all do not have obvious influence, do not find toxic reaction, convalescent period does not also have the retardance toxic reaction.
The present invention and function cure mainly relevant Pharmacodynamic test of active extract carried out anastalsis and the effect of coagulant blood, to the influence of platelet function and fibrinolytic system, to researchs such as uterine contraction, sex hormones secretion.Result of the test shows that the present invention has effect of coagulant blood and anastalsis, slightly promotes the circulation platelet aggregation, strengthens strength of uterine contraction and contraction frequency, and the neuroendocrine of estrogen is regulated certain influence; But the weight of fibrinolytic system function, uterus and ovary and growth, endometrial histology there is not obvious influence.Specifically see experiment one and table 1, experiment 2 and table 2.
Test the influence in a pair of mice bleeding time
Totally 80 of experiment material KM mices, male and female half and half, body weight 15～20g, is divided into 8 groups, available from Jiangxi Medical College's Experimental Animal Center by 10 every group.Positive drug is a Herba Clinopodii granule; Eye scissors, stopwatch, pin, slide, rayon balls.Be subjected to reagent thing (hemostasis peace) to be water extract, the alcohol extract of medicine of the present invention.
Experimentation
With mice by body weight be divided at random blank, positive drug, hemostasis peace water extract low, in and high dose, alcohol extract are low, in and totally 8 groups of high doses.Each treated animal is irritated stomach respectively and is given and normal saline and medicine totally 4 days.0.5h after the last administration cuts off the about 3mm of Mus tail with eye scissors, treats that blood flows out naturally to pick up counting, and inhales the liquid of dehematizing gently with filter paper every about 15 seconds, extremely hemorrhagely stops end naturally, and this time is the bleeding time (the results are shown in Table 1).Coagulation time test then is that mouse orbit blood sampling is dripped one and dripped to the cleaning slide, the about 5mm of drop of blood diameter, timing immediately, every about 15 seconds, provoke gently once inwards from the drop of blood edge with the cleaning pin, see to have or not the blood streak to provoke, begin to be clotting time (the results are shown in Table 2) to the time of provoking the blood streak from blood sampling.
The influence in table 1 pair mice bleeding time
Annotate: compare with the blank group, compare with the positive group * P＜0.01,
△P＜0.05,
△ △P＜0.01.
The result shows that all there were significant differences with blank group for the bleeding stopping period of each administration group, wherein the most remarkable with water extract high dose group; Compare with positive group, water extract high dose group, alcohol extract high dose group all have significant difference.
The influence of table 2 pair clotting time of mice
Annotate: compare with the blank group, compare with the positive group * P＜0.01,
△P＜0.05,
△ △P＜0.01.
The result shows that all there were significant differences with blank group for the clotting time of each administration group; The most remarkable with water extract high dose group equally; Compare with positive group, water extract high dose group, alcohol extract high dose group all have significant difference.
According to above clinical pharmacology result of study, the present invention has QI invigorating really and holds up unit, the effect of cooling blood and removing stasis, blood-arresting catamenia-regulating, can play fine therapeutical effect to dysfunctional uterine hemorrhage, have good effect, the cycle is short, price is low, do not have any untoward reaction, patient's medication is convenient, economical, can be continuously, long-term prescription and be unlikely to produce toxic and side effects to organ injuries such as liver and kidneys; Dysfunctional uterine hemorrhage is had good effect, is a kind of active drug of preventing and treating dysfunctional uterine hemorrhage that the patient takes like a shot.
The specific embodiment
Describe implementation of the present invention in detail below in conjunction with embodiment.
Embodiment 1: the preparation method of dissolved granule of the present invention: take by weighing each raw material: the Radix Astragali 500 grams, Radix Angelicae Sinensis 400 grams, the Radix Rehmanniae 400 grams, mountain Fructus Corni 400 grams, Rhizoma Imperatae 350 grams, Herba Leonuri 400 grams, charred RADIX RUBIAE 250 grams, Crinis Carbonisatus 150 grams, charred CORTEX MOUTAN 250 grams are pulverized said medicine and are ground into coarser powder, remove charred RADIX RUBIAE, charred CORTEX MOUTAN, outside the Crinis Carbonisatus, other 6 flavor Chinese medicine decocting secondary, 3 hours for the first time, 2 hours for the second time, filter, filtrate is condensed into thick paste, dry, pulverized 100 mesh sieves, add charred RADIX RUBIAE, charred CORTEX MOUTAN, the Crinis Carbonisatus fine powder, mixing, moistening, softening, take out when forming agglomerate, make granule.In like manner, press the method for embodiment 1, add suitable additives and can be made into tablet or capsule etc.Preparation of the present invention is brown granular agent or grey black tablet or capsule, the tool aromatic odor, and mildly bitter flavor acid, nontoxic, be pure Chinese medicine compound granule or tablet or capsule.
Claims (6)
1. Chinese medicine composition for the treatment of dysfunctional uterine hemorrhage, it is characterized in that: the weight portion of each crude drug is:
The Radix Astragali 300～600 weight portion Herba Leonuris 300～450 weight portion Radix Angelicae Sinensis 300～450 weight portions
The Radix Rehmanniae 300～450 weight portion mountain Fructus Corni 300～450 weight portion Rhizoma Imperataes 300～450 weight portions
Charred RADIX RUBIAE 180～300 weight portion charred CORTEX MOUTANs 180～300 weight portion Crinis Carbonisatus 120～180 weight portions;
Take by weighing each crude drug by weight, with the broken coarser powder that grinds into of above-mentioned raw materials medicated powder, except that charred RADIX RUBIAE, charred CORTEX MOUTAN, Crinis Carbonisatus, other 6 flavor Chinese medicine decocts with water secondary, filters, filtrate is condensed into thick extractum, drying was pulverized 100 mesh sieves, added charred RADIX RUBIAE, charred CORTEX MOUTAN, Crinis Carbonisatus fine powder, mixing, moistening, soften, take out when forming agglomerate, make granule or tablet or capsule.
2. a kind of Chinese medicine composition for the treatment of dysfunctional uterine hemorrhage according to claim 1 is characterized in that: its dosage form is effervescent granule electuary, capsule or tablet.
3. a kind of Chinese medicine composition for the treatment of dysfunctional uterine hemorrhage according to claim 2 is characterized in that: described capsule is the effervescent capsule.
4. a kind of Chinese medicine composition for the treatment of dysfunctional uterine hemorrhage according to claim 2 is characterized in that: described tablet is effervescent tablet or is dispersible tablet, with suitable coating material coating.
5. a kind of preparation method for the treatment of the Chinese medicine composition of dysfunctional uterine hemorrhage according to claim 1, it is characterized in that comprising the steps: taking by weighing by weight each crude drug, with the broken coarser powder that grinds into of above-mentioned raw materials medicated powder, except that charred RADIX RUBIAE, charred CORTEX MOUTAN, Crinis Carbonisatus, other 6 flavor Chinese medicine decocts with water secondary, filter, filtrate is condensed into thick extractum, dry, pulverized 100 mesh sieves, add charred RADIX RUBIAE, charred CORTEX MOUTAN, Crinis Carbonisatus fine powder, mixing, moistening, soften, take out when forming agglomerate, make granule or tablet or capsule.
6. a kind of preparation method for the treatment of the Chinese medicine composition of dysfunctional uterine hemorrhage according to claim 5 is characterized in that: described 6 flavor Chinese medicines decoct with water secondary, add 8 times in water for the first time, decoct 2 hours, add 6 times in water for the second time, decoct 1.5 hours; Spissated extractum proportion is 1.20.
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| CN2005100618147A CN1814196B (en) | 2005-12-05 | 2005-12-05 | Chinese medicine composition for treating functional metrorrhagia and preparation method thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112481B (en) * | 2007-08-20 | 2010-04-21 | 山西医科大学第二医院 | Medicine for treating functional uterine bleeding and method for preparing the same |
| CN101502634B (en) * | 2009-03-06 | 2011-11-02 | 陈殿红 | Chinese medicinal composition for treating uterine blood flow and preparation method thereof |
| CN105796818A (en) * | 2016-05-05 | 2016-07-27 | 宋云飞 | Medicine for treating dysfunctional uterine bleeding |
| CN106729594A (en) * | 2017-03-25 | 2017-05-31 | 成都海青生物科技有限公司 | It is a kind of effectively to treat decoction medicine of palace blood and preparation method thereof |
Citations (4)
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| CN1066061C (en) * | 1998-06-26 | 2001-05-23 | 樊祖仁 | Preparation of medicine for functional metrorrhagia |
| CN1435243A (en) * | 2003-02-27 | 2003-08-13 | 张晴龙 | Medicine for treating functional metrorrhagia and preparing process thereof |
| CN1502352A (en) * | 2002-11-22 | 2004-06-09 | 吴郁松 | Medicine for treatnig endometrorrhagia |
| CN1589894A (en) * | 2004-05-18 | 2005-03-09 | 烟台荣昌制药有限公司 | Medicinal composition for treating parafunctional metrorrhagia and its preparation method |
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2005
- 2005-12-05 CN CN2005100618147A patent/CN1814196B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066061C (en) * | 1998-06-26 | 2001-05-23 | 樊祖仁 | Preparation of medicine for functional metrorrhagia |
| CN1502352A (en) * | 2002-11-22 | 2004-06-09 | 吴郁松 | Medicine for treatnig endometrorrhagia |
| CN1435243A (en) * | 2003-02-27 | 2003-08-13 | 张晴龙 | Medicine for treating functional metrorrhagia and preparing process thereof |
| CN1589894A (en) * | 2004-05-18 | 2005-03-09 | 烟台荣昌制药有限公司 | Medicinal composition for treating parafunctional metrorrhagia and its preparation method |
Non-Patent Citations (4)
| Title |
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| 李春英.崩漏的辨治.光明中医杂志 3.1997,(3),17-19. |
| 李春英.崩漏的辨治.光明中医杂志 3.1997,(3),17-19. * |
| 陈秋梅.青春期功能性子宫出血的中医药研究进展.辽宁中医杂志26 8.1999,26(8),383-384. |
| 陈秋梅.青春期功能性子宫出血的中医药研究进展.辽宁中医杂志26 8.1999,26(8),383-384. * |
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Correction item: Patentee|Address Correct: Ningbo Yuanzhi Biotechnology Co., Ltd.|315100, room 10, building 68, Lane 402, Tai Mo Road, Ningbo, Zhejiang, Yinzhou District False: Yang Xiongzhi|315100 Zhejiang city of Ningbo province Yinzhou District County Road No. 888 east section of Zhejiang Pharmaceutical College Number: 30 Volume: 27 |
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Correction item: Patentee|Address Correct: Ningbo Yuanzhi Biotechnology Co., Ltd.|315100, room 10, building 68, Lane 402, Tai Mo Road, Ningbo, Zhejiang, Yinzhou District False: Yang Xiongzhi|315100 Zhejiang city of Ningbo province Yinzhou District County Road No. 888 east section of Zhejiang Pharmaceutical College Number: 30 Page: The title page Volume: 27 |
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Free format text: CORRECT: PATENTEE; ADDRESS; FROM: YANG XIONGZHI;315100 NINGBO, ZHEJIANG PROVINCE TO: NINGBO YUANZHIBIOTECHNOLOGY CO., LTD.;315100 NINGBO, ZHEJIANG PROVINCE |
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