CN1814021A - Ointment of diminishing gore and preparing method - Google Patents
Ointment of diminishing gore and preparing method Download PDFInfo
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- CN1814021A CN1814021A CN 200510016462 CN200510016462A CN1814021A CN 1814021 A CN1814021 A CN 1814021A CN 200510016462 CN200510016462 CN 200510016462 CN 200510016462 A CN200510016462 A CN 200510016462A CN 1814021 A CN1814021 A CN 1814021A
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Abstract
The present invention relates to a Xuefu Zhuyu ointment preparation with the functions of promoting blood circulation removing blood stasis, activating circulation of qi and stopping pain and its preparation method. It is made up by using 11 Chinese medicinal materials of Chinese angelica root, peach kernel, carthamus flower, red peony root, ligusticum root, licorice root and others through a certain preparation process, and can be made into ointment preparation or cataplasma preparation form.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, particularly relate to a kind of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain ointment of diminishing gore and preparation method thereof.
Background technology
XUEFU ZHUYU JIAONANG is a kind of classical Chinese patent medicine, and Ministry of Public Health standard WS2-B-0928-91 puts down in writing prescription:
Semen Persicae (stir-fry) 200g Radix Angelicae Sinensis 150g Fructus Aurantii (parched with bran) 100g Rhizoma Chuanxiong 75g Radix Bupleuri 50g Flos Carthami 150g Radix Achyranthis Bidentatae 150g Radix Paeoniae Rubra 100g Radix Rehmanniae 150g Radix Platycodonis 75g Radix Glycyrrhizae 50g
Function with cure mainly: blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.Be used for blood-stasis internal-depression, chest pain or headache, interior-heat blurring of vision accompanied with oppressive feeling, insomnia and dreamful sleep, severe palpitation, impatience and irascibility.
Other has applying date 2001.1.5, the patent record prescription of publication number CN1362075A " nano blood stasis dispersing preparation medicine and preparation method thereof ":
Nanometer Semen Persicae 10-50 part nano Chinese angelica 8-60 part nanometer Fructus Aurantii 10-70 part
Nanometer Rhizoma Chuanxiong 8-60 part nano bupleurum 10-60 part nano safflower 8-60 part
Nanometer Radix Achyranthis Bidentatae 8-50 part nanometer Radix Paeoniae Rubra 8-60 part nanometer Radix Rehmanniae 10-60 part
Nanometer Radix Platycodonis 5-50 part nanometer Radix Glycyrrhizae 5-30 part
Function with cure mainly: can be used for treatment of conditions such as headache, dizzy, brain injury sequela, angina pectoris.
Applying date 2004.8.19, the patent record of publication number CN1628766A " 'Xue Fu Zhu Yu ' preparation and preparation method thereof ": oral cavity disintegration tablet, gel, soft capsule, pellet, dispersible tablet, drop pill and preparation method thereof.
Pharmacology and Clinics of Chinese Materia Medica, 1990,6 (6), the 1-4 page or leaf, Peng Kang, Zheng Youshun work " side's of tearing open research of decoction for removing blood stasis---to microcirculatory pharmacological action " prove can microcirculation improvement, and the hypertension that causes because of the increase of blood capillary resistance is had certain inhibitory action.
Have not yet to see disclosing of topical agent-unguentum and preparation method thereof.
Summary of the invention
The unguentum that the objective of the invention is development external on existing 'Xue Fu Zhu Yu ' prescription basis, but the cataplasma that comprises ointment, plaster and controlled release drug administration makes that it absorbs soon, the ointment of diminishing gore of instant effect and preparation method thereof in symptoms such as contusions of treatment body surface, congestive edema.
For the purpose that reaches foregoing invention the invention provides a kind of 'Xue Fu Zhu Yu ' ointment, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae is a raw material, it is characterized in that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, the extract of Radix Glycyrrhizae 1-4% or its micropowder are that active component is with Mel, Oleum sesami is substrate, said extracted thing or its micropowder, Mel, the proportioning of Oleum sesami is: 1: 2-4: 0.1-0.3.
Described 'Xue Fu Zhu Yu ' ointment, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae are raw material, the extract or its micropowder that it is characterized in that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% are that active component is a substrate with Mel, Oleum sesami, and the optimum ratio of said extracted thing or its micropowder, Mel, Oleum sesami is: 1: 3: 0.2.
The preparation method of described 'Xue Fu Zhu Yu ' ointment, it is characterized in that: get Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae waters decoct 1-3 time, water consumption 6-10 doubly, each 1-3h, filter, collect filtrate, being evaporated to relative density is 1.10-1.30, be cooled to room temperature, add ethanol and make and contain the alcohol amount and be 70-80%, stir evenly, leave standstill 8-24h and make precipitation, get supernatant and reclaim ethanol, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder, add the Mel that 2-4 doubly measures, stir in the pasty state, add the Oleum sesami of 0.1-0.3 again, fully be mixed into paste, packing promptly gets ointment.
The preparation method of described 'Xue Fu Zhu Yu ' ointment, it is characterized in that: get Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae are with 80% ethanol extraction 1-2 time, with alcohol amount 5-8 doubly, each 0.5-2h, filter, collect filtrate, being evaporated to relative density is 1.10-1.20, be cooled to room temperature, the ethyl acetate extraction that adding 1-3 doubly measures 2-3 time, get supernatant and reclaim ethyl acetate, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder, add the Mel that 2-4 doubly measures, stir in the pasty state, add the Oleum sesami of 0.1-0.3 again, fully be mixed into paste, packing promptly gets ointment.
The preparation method of described 'Xue Fu Zhu Yu ' ointment is characterized in that: get the micropowder that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae micronizing on ultrafine crusher become particle diameter≤10 micron;
Get micropowder, add the Mel that 2-4 doubly measures, stir in the pasty state, add the Oleum sesami of 0.1-0.3 again, fully be mixed into paste, packing promptly gets ointment.
A kind of 'Xue Fu Zhu Yu ' plaster, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae are raw material, the extract or its micropowder that it is characterized in that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% are that active component is a substrate with the pressure-sensitive adhesive, and the proportioning of said extracted thing or its micropowder and pressure-sensitive adhesive is: 1: 1-10.
Described 'Xue Fu Zhu Yu ' plaster, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae are raw material, the extract or its micropowder that it is characterized in that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% are that active component is a substrate with the pressure-sensitive adhesive, and the proportioning of said extracted thing or its micropowder and pressure-sensitive adhesive is: 1: 8.
The preparation method of described 'Xue Fu Zhu Yu ' plaster, it is characterized in that: get Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae waters decoct 1-3 time, water consumption 6-10 doubly, each 1-3h, filter, collect filtrate, being evaporated to relative density is 1.10-1.30, be cooled to room temperature, add ethanol and make and contain the alcohol amount and be 70-80%, stir evenly, leave standstill 8-24h and make precipitation, get supernatant and reclaim ethanol, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder and add the pressure-sensitive adhesive that 1-10 doubly measures, comprise one or more mixture such as butyl acrylate, acrylic acid-2-ethyl caproite, glycidyl methacrylate, acrylic acid, with powder and pressure-sensitive adhesive mix homogeneously, on 80-120 ℃ of lining cloth that directly is coated in a certain size, make the black plaster plaster.(per 10 gram mastic are equivalent to give birth to 1.0-12.1g)
The preparation method of described 'Xue Fu Zhu Yu ' plaster, it is characterized in that: get Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae are with 80% ethanol extraction 1-2 time, with alcohol amount 5-8 doubly, each 0.5-2h, filter, collect filtrate, being evaporated to relative density is 1.10-1.20, be cooled to room temperature, the ethyl acetate extraction that adding 1-3 doubly measures 2-3 time, get supernatant and reclaim ethyl acetate, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder, add the pressure-sensitive adhesive that 1-10 doubly measures, comprise one or more mixture such as butyl acrylate, acrylic acid-2-ethyl caproite, glycidyl methacrylate, acrylic acid, with powder and pressure-sensitive adhesive mix homogeneously, on 80-120 ℃ of lining cloth that directly is coated in a certain size, make the black plaster plaster.(per 10 gram mastic are equivalent to 1.0-12.1g)
The preparation method of described 'Xue Fu Zhu Yu ' plaster is characterized in that: get the micropowder that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae micronizing on ultrafine crusher become particle diameter≤10 micron;
Get micropowder, add the pressure-sensitive adhesive that 1-10 doubly measures, comprise one or more mixture such as butyl acrylate, acrylic acid-2-ethyl caproite, glycidyl methacrylate, acrylic acid, with powder and pressure-sensitive adhesive mix homogeneously, on 80-120 ℃ of lining cloth that directly is coated in a certain size, make the black plaster plaster.
A kind of 'Xue Fu Zhu Yu ' cataplasma, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae is a raw material, it is characterized in that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, the extract of Radix Glycyrrhizae 1-4% or its micropowder are the transdermal enhancer laurocapram that active component adds 10%-30%, propylene glycol or both mixture, add the substrate that 1-10 doubly measures again, substrate comprises adhesive, wetting agent, filler, its proportioning are 1-5: 1-2.5: 1-8.
Described 'Xue Fu Zhu Yu ' cataplasma, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae is a raw material, it is characterized in that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, the extract of Radix Glycyrrhizae 1-4% or its micropowder for the active component optimum ratio are: the transdermal enhancer laurocapram of adding 30%, the substrate that adds 10 times of amounts again, substrate comprises PVAC polyvinylalcohol, glycerol, silica gel, its proportioning is 5: 2: 8
The preparation method of described 'Xue Fu Zhu Yu ' cataplasma, it is characterized in that: get Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae waters decoct 1-3 time, water consumption 6-10 doubly, each 1-3h, filter, collect filtrate, being evaporated to relative density is 1.10-1.30, be cooled to room temperature, add ethanol and make and contain the alcohol amount and be 70-80%, stir evenly, leave standstill 8-24h and make precipitation, get supernatant and reclaim ethanol, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder and micropowder, the transdermal enhancer laurocapram, propylene glycol or both mixture that add 10%-30%, add the substrate that 1-10 doubly measures again, substrate comprises adhesive, wetting agent, filler, its proportioning is 1-5: 1-2.5: 1-8, and wherein adhesive comprises sodium polyacrylate, sodium carboxymethyl cellulose, polyvinyl alcohol, methylcellulose, gelatin etc.; Wetting agent comprises glycerol, Polyethylene Glycol, sorbitol, glycerol etc.; Filler comprises silica gel, calcium carbonate, Bentonite, zinc oxide etc., and powder and substrate fully are mixed into paste, is coated on a certain size the lining cloth, and the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.
The preparation method of described 'Xue Fu Zhu Yu ' cataplasma, it is characterized in that: get Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae are with 80% ethanol extraction 1-2 time, with alcohol amount 5-8 doubly, each 0.5-2h, filter, collect filtrate, being evaporated to relative density is 1.10-1.20, be cooled to room temperature, the ethyl acetate extraction that adding 1-3 doubly measures 2-3 time, get supernatant and reclaim ethyl acetate, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder and micropowder, the transdermal enhancer laurocapram, propylene glycol or both mixture that add 10%-30%, add the substrate that 1-10 doubly measures again, substrate comprises adhesive, wetting agent, filler, its proportioning is 1-5: 1-2.5: 1-8, and wherein adhesive comprises sodium polyacrylate, sodium carboxymethyl cellulose, polyvinyl alcohol, methylcellulose, gelatin etc.; Wetting agent comprises glycerol, Polyethylene Glycol, sorbitol, glycerol etc.; Filler comprises silica gel, calcium carbonate, Bentonite, zinc oxide etc., and powder and substrate fully are mixed into paste, is coated on a certain size the lining cloth, and the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.
The preparation method of described 'Xue Fu Zhu Yu ' cataplasma is characterized in that: get the micropowder that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae micronizing on ultrafine crusher become particle diameter≤10 micron;
Get fine powder and micropowder, the transdermal enhancer laurocapram, propylene glycol or both mixture that add 10%-30%, add the substrate that 1-10 doubly measures again, substrate comprises adhesive, wetting agent, filler, its proportioning is 1-5: 1-2.5: 1-8, and wherein adhesive comprises sodium polyacrylate, sodium carboxymethyl cellulose, polyvinyl alcohol, methylcellulose, gelatin etc.; Wetting agent comprises glycerol, Polyethylene Glycol, sorbitol, glycerol etc.; Filler comprises silica gel, calcium carbonate, Bentonite, zinc oxide etc., and powder and substrate fully are mixed into paste, is coated on a certain size the lining cloth, and the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.
Three. technical study
(1) preparation technology's research
Technology (1)
1. the investigation of water extraction process: select different amounts, extraction time, extraction time three factors, the testing program of three levels.Factor level sees Table 1, is component target to survey paeoniflorin content, carries out orthogonal test, and extraction process by water optimization is studied.
Table 1 factor level table L
9(3
3)
| Level | Factor | ||
| Water consumption A (doubly) | Same B (h) during extraction | Extraction time C | |
| 1 2 3 | 10 8 6 | 1 2 3 | 1 2 3 |
The preparation of orthogonal experiment sample: take by weighing 9 parts of recipe quantity 100g medical materials, consumption, extraction time, the extraction time with different water extracts respectively respectively, gets extracting solution.Carry out the pre-treatment of sample and measure content of paeoniflorin by content assaying method, select L for use
9(3
3) orthogonal design table tests, and the results are shown in Table 2
Table 2 water extraction process is investigated L
9(3
3) test card
R value: RC＞RA＞RB
As shown in Table 2, three factors all have certain influence to paeoniflorin content.The influence degree of each factor is followed successively by C＞A＞B, wherein A factor A
3＞A
2＞A
1, B factor B
3＞B
2＞B
1, C factor C
3＞C
2＞C
1In factors, among the data ABC among K2 and the ABC K3 approximate substantially, consider that energy consumption and cost are low, save time, suitable big production adopted A
2And A
3, B
2, C
2Factor.Determine extraction process by water condition: A
2/ A
3B
2C
2, promptly adopting 8 times and 6 times of water gagings extractions twice, each 2 hours optimum condition extracts.And carried out three batches of verification experimental verifications, by the operation of said extracted method, measure content.Calculate rate of transform result such as following table 3:
Three batches of tests of table 3 rate of transform result
| Sample 1 | Sample 2 | Sample 3 | |
| The content rate of transform (%) X | 74.21 | 79.31 76.68 | 76.52 |
Three crowdes of checking results show: content rate of transform average is 76.68%.And stable process conditions, good reproducibility can be operated.
2. the investigation of aqueous extraction-alcohol precipitation technology: behind the water extraction, its impurity is more in technology, directly influences the foundation of dosage form, carrying out precipitate with ethanol after having selected water to carry, serves as to investigate index to measure content, gets recipe quantity 900g medical material, pressing the water extraction process condition extracts, water extraction twice each 2 hours, is measured relative density when its aqueous extract is concentrated into the medical material different proportion, add ethanol respectively, make it reach the alcohol amount that contains of variable concentrations, the precipitate with ethanol different time is investigated its content.Select L for use
9(3
3) orthogonal design table tests, and the results are shown in Table 4, table 5, table 6
Table 4 factor level table
Table 5 aqueous extraction-alcohol precipitation technology is investigated L
9(3
3) test computer chart result
R：A＞B＞C
Table 6 analysis of variance table
| Soruces of variation | Quadratic sum | Degree of freedom | Mean square | F | Factor affecting |
| Water dope density A alcohol precipitation concentration B extraction time C sum of the deviations | 7410.383 26.233 8.834 120.547 7565.997 | 2 2 2 2 8 | 3705.192 13.117 4.417 60.274 | 61.472 0.218 0.073 | Significantly or not remarkable |
The results of analysis of variance shows: orthogonal test A factor has remarkable influence, and B, C factor affecting are not remarkable.
Orthogonal experiments shows: the relative density of water extracting liquid has certain influence to content, and the relative density of R value explanation water dope is a principal element, and alcohol precipitation concentration and precipitate with ethanol time are secondary causes.The degree of each factor affecting is followed successively by RA＞RB＞RC, and A in the A factor
1And A
2Numerical value is approximate substantially, but A
2Than A
1It is low to save the pure amount cost of one times use, and adopts A
2The B factor adopts B
2, C factor numerical value is approximate substantially, considers from operability, adopts C
2So determine A
2B
2C
2Condition is promptly: water extraction concentrated solution to relative density is 1.25, and precipitate with ethanol makes and reaches that to contain the alcohol amount be 70%, precipitate with ethanol time 12h.
Above-mentioned technology has been carried out three batches of checkings,, measured the rate of transform result such as the following table 7 of content by the operation of said extracted method
Three batches of checkings of table 7 precipitate with ethanol content rate of transform result
| Sample 1 | Sample 2 | Sample 3 | |
| The content rate of transform (%) X | 76.54 | 75.87 75.46 | 73.99 |
Content rate of transform meansigma methods is 75.46% as a result.Illustrate that this test technology condition is reliable.
3. dry thing content rate of transform investigation result: by above-mentioned aqueous extraction-alcohol precipitation technology extraction, get extracting solution and concentrate clear paste, put vacuum drying in the drying baker, temperature gets dry thing at 60-75 ℃, measures content, tests content rate of transform result such as table 8 for three batches
The dry thing content of table 8 rate of transform is investigated the result
| NO. | Sample 1 | Sample 2 | Sample 3 | Average |
| Content rate of transform % | 71.43 | 72.54 | 75.11 | 73.03 |
The result shows that the content rate of transform of extracting solution concentrated dry thing is 73.03%, is 95.8% of the water extract-alcohol precipitation liquid hold-up rate of transform.Illustrate that this drying condition is feasible.
Technology (2)
The investigation of alcohol extraction ethyl acetate extraction technology: get recipe quantity 100g medical material, alcohol extraction 2 times concentrates the back and adds a certain amount of ethyl acetate, extracts, and investigates its paste volume.Select L for use
9(3
3) orthogonal design table tests, and the results are shown in Table 9, table 10, table 11
Table 9 factor level table
| Level | Factor | ||
| Alcohol adding amount (doubly) | Extraction time (h) | Ethyl acetate amount (doubly) | |
| 1 2 3 | 5 8 10 | 0.5 1 2 | 3 2 1 |
Table 10 alcohol extraction ethyl acetate extraction technology is investigated L
9(3
3) test computer chart result
R：C＞A＞B
Table 11 analysis of variance table
| Soruces of variation | Quadratic sum | Degree of freedom | Mean square | F | Factor affecting |
| Alcohol adding amount extraction time ethyl acetate amount sum of the deviations | 0.72 0.31 16.35 1.02 18.4 | 2 2 2 2 8 | 0.36 0.155 8.175 0.51 | 0.71 0.30 16.03 | Significantly or not remarkable |
The results of analysis of variance shows: the orthogonal test factor affecting is not remarkable.
Orthogonal experiments shows: the ethyl acetate amount has certain influence to paste volume, and R value explanation ethyl acetate amount is a principal element, and alcohol adding amount and extraction time are secondary causes.The degree of each factor affecting is followed successively by RC＞RA＞RB, and A factor A
1=A
2＜A
3, B factor B
1=B
2＜B
3, C factor C
3＜C
2＜C
1For making extracts active ingredients complete, so determine A
1/ A
2B
2C
3Condition is promptly: with twice of alcohol extraction (8,5 times), and each 1h, the ethyl acetate amount is 1 times of amount.
Technology (3)
The investigation of micronizing process: adopt Chinese medicine superfine grinding unit that recipe quantity 200g is pulverized, by fragmentation, coarse crushing, screening, superfine grinding process, obtain≤micropowder of 10um.With the micropowder recovery rate is index, carries out three batches of experiments and sees Table 12
Three batches of shredding data summary sheets of table 12
| Recipe quantity | Mean diameter | The micropowder amount of≤10um | Recovery rate | |
| First second batch the 3rd batch | 200g 200g 200g | 5-8um 6-8um 5-10um | 199.2g 198.8g 198.2g | 99.6％ 99.4％ 99.1％ |
Experimental result shows, smashing fineness can reach the 200-8000 order, the cell wall breaking rate of Chinese crude drug is up to more than 99%, and all remains on more than 95% of crude drug content by the mensuration to paeoniflorin content, illustrates that the superfine grinding process has effectively kept the effective ingredient in the prescription.
(2) preparations shaping technology
Moulding process (1)
1. the selection that adds the Mel amount: selected above-mentioned technology according to drug effect, be prepared into the technology extract stable
Ointment need add Mel makes better molding, respectively with 1 times of amount, and 2 times of amounts, the Mel of 3 times of amounts joins in the dry thing, investigates its molding situation and sees 13
Table 13 adds the investigation of supplementary product starch amount
| Add Mel amount (doubly) | 1 | 2 | 3 |
| The molding situation | Medicated powder is too much, and molding is poor | Medicated powder is many, does not become pasty state | Become pasty state, evenly |
The result shows that the said preparation content is measured forming with 3 times, uniform pasty state, and flowability is also good, so the Mel of having selected to add 3 times of amounts makes molding.But find that abnormal smells from the patient is difficult for being accepted by the people, add correctives Oleum sesami for this reason again and investigate.
2. the selection that adds the Oleum sesami amount: in ointment, add respectively with 10%, 20%, the Oleum sesami of 30% different proportion, 25 ℃ of room temperatures, under the condition of humidity 45%, with observe 24 hours not stratified be standard, the results are shown in Table 14
Table 14 adds the not investigation of commensurability Oleum sesami
| Perfuming oil mass % | 10 | 20 | 30 |
| The layering situation | Not stratified, abnormal smells from the patient is still deposited | Not stratified, abnormal smells from the patient perfume (or spice) | Layering |
The result shows, its forming of the addition with 20%, and the no lamination of room temperature placement show stable.Event selected 20% is feasible for the Oleum sesami addition.
Moulding process (2)
1. the selection of pressure sensitive adhesive: select following substrate for use, easily melting with mastic is standard.The results are shown in Table 15
The investigation of table 15 pressure sensitive adhesive
| Kind | Butyl acrylate | Acrylic acid-2-ethyl caproite | Glycidyl methacrylate | Acrylic acid |
| The fusion situation | Yi Rong, and evenly, forming | Yi Rong evenly, puts layering for a long time, and molding is poor | Yi Rong is equipped with caking phenomenon for a long time, and molding is poor | Do not melt |
The result shows, as its forming of substrate, and room temperature is placed no layering, caking phenomenon, stable in properties with butyl acrylate.So selected pressure sensitive adhesive butyl acrylate is a substrate.
2. the investigation of pressure sensitive adhesive addition and application temperature: add the pressure sensitive adhesive butyl acrylate of 5 times, 8 times, 10 times amounts respectively, be coated on the lining cloth in 100 ℃ and 120 ℃, so that not fuel-displaced the caking is observation index after coating and the cooling.The results are shown in Table 16
The investigation of table 16 pressure sensitive adhesive addition and application temperature
| Butyl acrylate | 100 ℃ of coatings | 120 ℃ of coatings | ||||
| 5 times of amounts | 8 times of amounts | 10 times of amounts | 5 times of amounts | 8 times of amounts | 10 times of amounts | |
| The result | The mastic mealiness is big, cast is arranged, and is difficult for coating | Mastic is even, and viscosity is big during coating, applies inhomogeneous | Mastic is soft, not molding, coating difficulty | The mastic mealiness is big, cast is arranged, caking phenomenon is arranged | Mastic is even, and coating does not evenly have fuel-displaced caking phenomenon | Mastic is soft, not molding, and the coating difficulty has fuel-displaced phenomenon |
The result shows, with the butyl acrylate of 8 times of amounts as its forming of substrate, 120 ℃ of coatings evenly, no adhesion, cooling is no fuel-displaced, caking phenomenon afterwards, moisture retention is good, stable in properties.
Moulding process (3)
1. the selection of transdermal enhancer and addition: get 10g mastic (being equivalent to 9.3g crude drug amount), add laurocapram, propylene glycol or both mixture as promoter, addition with 10%, 20%, 30%, test by animal skin, to different time animal body fluid and external drug residue quantitative analysis, investigate best promoter and proportioning.The results are shown in Table 17
The selection of table 17 transdermal enhancer
| Addition | Time | Animal body fluid crude drug amount (g) | External drug residue (g) | The body intrinsic permeability | |
| Laurocapram | 10％ | 6 hours | 2.0 | 7.3 | 21.5％ |
| 12 hours | 3.5 | 5.8 | 37.6％ | ||
| 24 hours | 6.1 | 3.2 | 65.6％ | ||
| 20％ | 6 hours | 2.0 | 7.3 | 21.5％ | |
| 12 hours | 4.1 | 5.2 | 44.0％ | ||
| 24 hours | 6.7 | 2.6 | 72.0％ | ||
| 30％ | 6 hours | 3.4 | 5.9 | 36.5％ | |
| 12 hours | 6.9 | 2.4 | 74.2％ | ||
| 24 hours | 8.5 | 0.8 | 91.4％ | ||
| Propylene glycol | 10％ | 6 hours | 1.3 | 8.0 | 13.4％ |
| 12 hours | 5.4 | 3.9 | 58.0％ | ||
| 24 hours | 6.6 | 2.7 | 70.9％ | ||
| 20％ | 6 hours | 2.9 | 6.4 | 31.2％ | |
| 12 hours | 5.2 | 4.1 | 55.9％ | ||
| 24 hours | 7.2 | 2.1 | 77.4％ | ||
| 30％ | 6 hours | 2.4 | 6.9 | 25.8％ | |
| 12 hours | 4.8 | 4.5 | 51.6％ | ||
| 24 hours | 6.7 | 2.6 | 72.0 | ||
| Laurocapram and propylene glycol 1: 2 | 10％ | 6 hours | 0.5 | 8.8 | 5.4％ |
| 12 hours | 2.4 | 6.9 | 25.8 | ||
| 24 hours | 4.1 | 5.2 | 44.0％ | ||
| 20％ | 6 hours | 0.5 | 8.8 | 5.4％ | |
| 12 hours | 2.5 | 6.8 | 26.9％ | ||
| 24 hours | 4.6 | 4.7 | 49.4％ | ||
| 30％ | 6 hours | 0.8 | 8.5 | 8.6％ | |
| 12 hours | 3.1 | 6.2 | 33.3％ | ||
| 24 hours | 5.4 | 3.9 | 58.1％ |
The result shows: laurocapram and propylene glycol (1: 2) mixture transdermal effect is poor, and is effective with a kind of promoter not as single, and 30% laurocapram is in the drug of topical application almost all percutaneous absorptions after 24 hours, and permeability reaches 91.4%, best results.
2. choice of base: substrate is made up of adhesive, wetting agent, filler, carries out the mouldability qualitative observation by the part combination to different substrates, selects substrate combination.The results are shown in Table 18
Table 18 choice of base
| Substrate combination (adhesive+wetting agent+filler) | The molding situation |
| Sodium Polyacrylate+glycerine+silica gel Sodium Polyacrylate+polyethylene glycol+bentonite sodium carboxymethylcellulose+polyethylene glycol+calcium carbonate sodium carboxymethylcellulose+sorbierite+zinc oxide polyvinyl alcohol+sorbierite+bentonite polyvinyl alcohol+glycerine+silica gel methylcellulose+glycerine+zinc oxide methylcellulose+glycerine+calcium carbonate | Easy-formation, but viscosity is bigger, it is poor to be difficult for the coating molding, it is poor to be equipped with the caking phenomenon molding for a long time, be equipped with the caking phenomenon easy-formation for a long time, it is poor to be equipped with fuel-displaced phenomenon molding for a long time, be equipped with fuel-displaced for a long time, the caking phenomenon forming, viscosity is moderate, be easy to coating, there is not fuel-displaced caking phenomenon easy-formation, but viscosity is big, it is poor to be equipped with fuel-displaced phenomenon molding for a long time, and dry cast is arranged |
The result shows: polyvinyl alcohol, glycerol, silica gel combination forming are effective, are easy to coating, no fuel-displaced, caking phenomenon generation, stable in properties.
3. the investigation of substrate addition: with the molding situation is reference, investigates the substrate addition.The results are shown in Table 19
The investigation of table 19 substrate addition
| The substrate addition | 3 times of amounts | 5 times of amounts | 8 times of amounts | 10 times of amounts |
| The molding situation | Molding is poor, stickiness is little | Molding is general, is equipped with fuel-displaced phenomenon for a long time | Molding is general, is equipped with fuel-displaced phenomenon for a long time | Forming, stickiness is moderate, does not have fuel-displaced phenomenon |
The result shows: add polyvinyl alcohol, glycerol, the silica-gel composition good forming effect of 10 times of amounts of dry thing, do not have fuel-displaced phenomenon stable in properties takes place.
4. the selection of substrate composition: with plastic property test and adhesion test situation is reference, and has considered the ease for operation of experiment, has carried out the selection experiment of substrate composition, the results are shown in Table 20
Plastic property test: each 1 of sample thief, put in 37 ℃, the climatic chamber of relative humidity 64% 30 minutes, take out, with clip sample is fixed on the smooth steel plate, steel plate and horizontal plane inclination angle are 60 °, place 24 hours, the cream face should not have the trickling phenomenon.
Adhesion test: each 1 of sample thief, at room temperature, remove the lid lining, place long 30cm, become the inclined-plane spin device central authorities of 15 ° or 30 ° with horizontal plane, cream is towards last, and top, inclined-plane 10cm and bottom 15cm cover with the thick mylar of 0.025mm, and 5cm cream face is reserved in the centre, freely roll down from each sample beveled top end with No. 1 steel ball, should be able on test section, cling steel ball.
The selection of table 20 substrate composition
| Numbering | Polyvinyl alcohol: glycerol: silica gel | The result | ||
| 1 2 3 4 5 | 1 1 3 3 5 | 1 2 2 2.5 1 | 1 3 8 5 3 | Plastic property, poor, the caking of adhesion, plastic property not easy to operate, poor, the caking of adhesion, adhesion not easy to operate is poor, the good adhesion of plastic property is poor, plastic property is good, idol has the caking adhesion good, and plastic property is poor, idol has caking |
| 6 | 5 | 2 | 8 | Adhesion is good, and plastic property is good, and is easy to operate |
The result shows: the proportioning of substrate is a polyvinyl alcohol: glycerol: silica gel be 5: 2: 8 o'clock more satisfactory.
(3) unguentum study on the stability
In " specification requirement of study of tcm new drug " promulgated and enforced according to National Drug Administration, the specification requirement of new Chinese medicine steady quality Journal of Sex Research regulation.Make 'Xue Fu Zhu Yu ' ointment, plaster and cataplasma by formulating technology, under the room temperature character, moisture retention, paeoniflorin content and microbiological examination project are observed.The result shows: every detection index meets national unguentum quality standard, and room temperature was placed six months, steady quality.
(4) the pharmacodynamics test data relevant with the scope of application
1. test objective: 'Xue Fu Zhu Yu ' ointment, plaster plaster, cataplasma are by Semen Persicae, Radix Rehmanniae, Radix Paeoniae Rubra, Flos Carthami, Radix Achyranthis Bidentatae etc. the ten refining compound external-use unguentum that forms of medical material simply, have blood circulation promoting and blood stasis dispelling, the effect of promoting the circulation of QI to relieve pain.We take the different animals model to observe its swelling that soft tissue injury is caused, swell and ache and microcirculatory treatment and improvement effect.
2. test material: 1. medicine: 3 kinds of 'Xue Fu Zhu Yu ' ointment, 3 kinds of hard plasters, 3 kinds of cataplasmas are provided by Tianjin Hongrentang Pharmaceutical Co., Ltd.; The aspirin sheet, factory provides by the northwest synthesis pharmaceutical.2. animal: Wistar kind rat, body weight 200-250g male and female half and half, animal housing provides by Tianjin Inst. of Materia Medica.
3. method and result
(1) soft tissue injury is caused the therapeutical effect of swelling
1. to the bullate effect of the rat Ovum Gallus domesticus album foot sole of the foot: get 110 of rats, be divided into 11 groups at random, 10 every group.Apply this product ointment 50 and 100mg around the hind leg ankle joint of the high low dose group rat left and right sides; Stick hard plaster 50 and 100mg, cataplasma 100 and 200mg.Positive controls is given aspirin 0.1g/kg.More than 11 groups apply (giving) medicines continuously after 4 days, inject 10% Ovum Gallus domesticus album 0.05ml by the left back sufficient sole of the foot of each Mus portion is subcutaneous to the ankle joint direction, ointment is removed in the drug of topical application immediately 1 hour afterwards.Cause two side ankle joint girths about the measurement in 1,2,3,4 hour of scorching back, its difference is the swelling degree.The result shows that 'Xue Fu Zhu Yu ' ointment, hard plaster, cataplasma have obvious inhibition and therapeutical effect to rat Ovum Gallus domesticus album pedal swelling, are better than the aspirin positive controls.
2. to the bullate effect of the rat carrageenan foot sole of the foot: 110 of rats are divided into 11 groups at random.Grouping and medication are with experiment 1..In administration after 4 days, Mus left and right sides limb foot sole of the foot portion is subcutaneous injects 1% carrageenin 0.05ml to the ankle joint direction by each, causes scorching back 0.5,1,2,4,6 hour and measures and calculate the ankle swelling degree with method.The result shows the acute inflammation swelling due to 'Xue Fu Zhu Yu ' ointment, hard plaster, cataplasma local external application can significantly the alleviating carrageenin, obviously is better than the aspirin positive controls.
3. to the bullate effect of the rat formaldehyde foot sole of the foot: 110 of rats, 1. grouping tests together with medication.Behind the successive administration 4 days, inject 2.5% formaldehyde 0.5ml to the ankle joint direction by the sufficient sole of the foot of each Mus left hind portion is subcutaneous.Cause scorching back 2,5,8,24 hours, measure and calculate limb ankle swelling degree.Change every day simultaneously and apply once.As seen the inflammation swelling due to 'Xue Fu Zhu Yu ' ointment, hard plaster, cataplasma local external application can significantly the alleviating formaldehyde, heavy dose of effect is better than low dose, and is suitable with the effect of aspirin positive controls.
(2) analgesic activity (mouse writhing method)
Get 50 of mices, the about 4cm of abdominal part cropping, wipe again with Calcium Glycolate (commercially available depilatory cream) and lose hair or feathers, next day, to distinguish coating or stick 'Xue Fu Zhu Yu ' ointment 0.1 or 0.2g, hard plaster 0.1 or 0.2g, cataplasma 0.2 or 0.4g in depilation, positive controls gavages aspirin 0.2g/kg, once a day, each organized successive administration after 4 days, and intraperitoneal injection 0.6% glacial acetic acid solution 10ml/kg observes 15 minutes mouse writhing number of times immediately.As seen, 'Xue Fu Zhu Yu ' ointment, hard plaster, cataplasma can reduce acetic acid and cause the mouse writhing number of times that causes of pain.
(3) improve the local microcirculation effect
Select 90 mices for use,, be divided into 9 groups at random, 10 every group, equal male and female dual-purpose.Normal control group, model control group, 'Xue Fu Zhu Yu ' ointment, hard plaster, cataplasma 2,4,8g crude drug/kg dosage group are established in experiment.The coating or stick administration, once a day, continuous 7 days, normal control group and model control group were all irritated stomach and are waited capacity 0.5%CMC.After the last administration 1 hour, lumbar injection pentobarbital sodium 50mg/kg after the anesthesia, dripped olive oil on microscope slide, and mice left side ear is open and flat, fixing.Observation and the microvascular fluidised form of record Mice Auricle, erythrocyte aggregation degree, point of intersect of the capillary network number under 50 power microscopes are as numerical value before the moulding.Tail vein injection 10% high molecular dextran 0.1ml/10g body weight (except the normal control group) then, back 5 minutes, 10 minutes, 20 minutes, 30 minutes microvascular fluidised forms in same position of record injection, erythrocyte aggregation degree, point of intersect of the capillary network number, relatively the effect of 'Xue Fu Zhu Yu ' ointment, hard plaster, cataplasma is observed in the variation before and after the moulding.Fluidised form and erythrocyte aggregation degree adopt grade preface value method to carry out significance test, and the point of intersect of the capillary network number adopts pairing t-value method to carry out significance test.
The standard fluidised form of observation index:
1 grade: linear flow, blood flow is fast, is smooth streak, no granular sensation.
2 grades: line grain stream, blood flow is very fast, is streak, and granular sensation is arranged slightly.
3 grades: the grain linear flow, blood flow is slower, though become line continuously, obvious granular sensation is arranged.
4 grades: grain stream, blood flow is slow, and axial flow, edge stream mix, as the silt sample.
5 grades: the grain unhurried current, blood flow is the silt sample, continuously sluggish flow.
6 grades: grain pendulum stream, blood flow is the silt sample, though flow swing forward.
7 grades: stagnate, blood flow is motionless.
The erythrocyte aggregation degree
0 grade: blood flow does not have granular sensation.
1 grade: the slight gathering, blood flow obviously has granular sensation, and axial flow, edge stream mix.
2 grades: moderate is assembled, and erythrocyte aggregation becomes agglomerate bigger, that differ in size, and is tightr.
3 grades: severe is assembled, and a plurality of erythrocyte aggregations become intensive agglomerate, and profile is not whole, differs in size, with separating plasma.
It is 1mm that the point of intersect of the capillary network number is chosen area
2Around surround the fixed area on border by blood capillary, count the number of hits of blood capillary and border blood vessel in this zone.
Result of the test shows: compare with the normal control group, the model control group mice is before the moulding of injection high molecular dextran, blood fluidised form, erythrocyte aggregation degree, point of intersect of the capillary network number average no significant difference, after the moulding 5,10,20,30 minutes, blood flow obviously slows down, erythrocyte aggregation obviously increases, the point of intersect of the capillary network number obviously reduces (30 minutes no significant differences), show to form microcirculation disturbance the model copy success.Compare with model control group, each dosage group blood fluidised form, erythrocyte aggregation degree, point of intersect of the capillary network number average no significant difference before the moulding, after the moulding 5,10,20,30 minutes, the different unguentum 4 of 'Xue Fu Zhu Yu ', 8g crude drug/kg dosage group all can obviously reduce blood fluidised form rank and erythrocyte aggregation (5 minutes, 10 minutes and 20 minutes), obviously increase point of intersect of the capillary network number (5 minutes, 10 minutes and 20 minutes).
The invention effect:
1. active ingredient made full use of during above-mentioned three kinds of preparation technologies all will write out a prescription effectively, and be purified by effective technology of preparing, results of pharmacodynamic test shows, to tangible pain relieving, detumescence effect, has the effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain because the skin surface that a variety of causes causes has swollen and ache.
2. above-mentioned three kinds of preparations shaping technologies are external, to skin nonirritant, stable in properties.Wherein ointment mastic exquisiteness, soft and smooth, be easy to coating and do not melt, volume is little, and is easy to use and carry; Plaster can play a protective role and sealing process to lesions position, is beneficial to focus and recovers fast; The pharmaceutical properties of cataplasma is stable, has that Transdermal absorption is fast, good permeability and characteristics such as release progressively, compares with peroral dosage form, no liver sausage first-pass effect is not subjected to the gastrointestinal tract degraded to influence the bioavailability height, compare with injection, easy to use, no pain is compared with ointment, dosage is accurate, absorption area is fixed, and compares the phenomenon of no skin allergy and pollution clothes with black plaster, rubber plaster.
3. this prescription is many for a long time as the interior oral formulations of use, and effect significantly now is made into external preparation, has not only increased treating the application of wound aspect swelling and ache, and has expanded the scope of application of this prescription and new dosage form in a sense.
4. the superfine technique smashing fineness can reach the 200-8000 order, can keep on the basis of effective ingredient 95%, and the cell wall breaking rate of Chinese crude drug up to more than 99%, is guaranteed that active constituents of medicine is not destroyed, and cost is low.
The specific embodiment
The present invention adopts prescription:
Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4%
Two, method for making:
1. preparation technology
(1) get ten Herba indigoferae Pseudotinctoriae waters such as Radix Angelicae Sinensis and decoct 1-3 time, water consumption 6-10 doubly, 1-3h at every turn, filter, collect filtrate, being evaporated to relative density is 1.10-1.30, be cooled to room temperature, add ethanol and make and contain the alcohol amount and be 70-80%, stir evenly, leave standstill 8-24h and make precipitation, get supernatant and reclaim ethanol, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve.
(2) get ten Herba indigoferae Pseudotinctoriae such as Radix Angelicae Sinensis with 80% ethanol extraction 1-2 time, with alcohol amount 5-8 doubly, each 0.5-2h, filter, collect filtrate, being evaporated to relative density is 1.10-1.20, be cooled to room temperature, the ethyl acetate extraction that adding 1-3 doubly measures 2-3 time is got supernatant and is reclaimed ethyl acetate, is evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve.
(3) get the micropowder that ten Herba indigoferae Pseudotinctoriae micronizing on ultrafine crusher such as Radix Angelicae Sinensis become particle diameter≤10 micron.
2. preparations shaping technology
Three kinds of preparation technologies obtain in above-mentioned 1 fine powder and micropowder all can adopt following method to make ointment, plaster and cataplasma.Concrete grammar is as follows:
(1) get fine powder and micropowder, add the Mel that 2-4 doubly measures, stir in the pasty state, add the Oleum sesami of 10-30% again, fully be mixed into paste, packing promptly gets ointment.(per 10 gram ointment are equivalent to crude drug 2.0-22.8g)
(2) get fine powder and micropowder, add the pressure-sensitive adhesive that 1-10 doubly measures, comprise one or more mixture such as butyl acrylate, acrylic acid-2-ethyl caproite, glycidyl methacrylate, acrylic acid, with powder and pressure-sensitive adhesive mix homogeneously, on 80-120 ℃ of lining cloth that directly is coated in a certain size, make the black plaster plaster.(per 10 gram mastic are equivalent to crude drug 1.0-12.1g)
(3) get fine powder and micropowder, the transdermal enhancer laurocapram, propylene glycol or both mixture that add 10%-30%, add the substrate that 1-10 doubly measures again, substrate comprises adhesive, wetting agent, filler, its proportioning is 1-5: 1-2.5: 1-8, and wherein adhesive comprises sodium polyacrylate, sodium carboxymethyl cellulose, polyvinyl alcohol, methylcellulose, gelatin etc.; Wetting agent comprises glycerol, Polyethylene Glycol, sorbitol, glycerol etc.; Filler comprises silica gel, calcium carbonate, Bentonite, zinc oxide etc., and powder and substrate fully are mixed into paste, is coated on a certain size the lining cloth, and the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.(per 10 gram mastic are equivalent to crude drug 1.0-10.0g)
Three, optimised process:
Radix Angelicae Sinensis 12%, Semen Persicae 16%, Flos Carthami 12%, Radix Achyranthis Bidentatae 12%, Radix Rehmanniae 12%, Radix Paeoniae Rubra 8%, Fructus Aurantii 8%, Radix Platycodonis 6%, Rhizoma Chuanxiong 6%, Radix Bupleuri 4%, Radix Glycyrrhizae 4%
1. preparation technology
(1) gets ten Herba indigoferae Pseudotinctoriae waters such as Radix Angelicae Sinensis and decoct 2 times, water consumption 8 and 6 times, each 2h, filter, collect filtrate, being evaporated to relative density is 1.25, be cooled to room temperature, add ethanol and make that to contain the alcohol amount be 70%, stir evenly, leave standstill 12h and make precipitation, get supernatant and reclaim ethanol, be evaporated to relative density and be 1.40 thick paste, 65 ℃ of vacuum dryings, get dry thing, pulverize, cross 100 mesh sieves.
(2) get ten Herba indigoferae Pseudotinctoriae such as Radix Angelicae Sinensis with 80% ethanol extraction 2 times, with 8 and 5 times of alcohol amounts, each 1h, filter, collect filtrate, being evaporated to relative density is 1.15, be cooled to room temperature, add the ethyl acetate extraction 2 times of 1 times of amount, get supernatant and reclaim ethyl acetate, be evaporated to relative density and be 1.40 thick paste, 65 ℃ of vacuum dryings, get dry thing, pulverize, cross 100 mesh sieves.
(3) get the micropowder that ten Herba indigoferae Pseudotinctoriae micronizing on ultrafine crusher such as Radix Angelicae Sinensis become particle diameter≤10 micron.
2. preparations shaping technology
(1) get fine powder and micropowder, add the Mel of 3 times of amounts, stir in the pasty state, add 20% Oleum sesami again, fully be mixed into paste, packing promptly gets ointment.
(2) get fine powder and micropowder, add the pressure-sensitive adhesive butyl acrylate mix homogeneously of 8 times of amounts, on 120 ℃ of lining cloth that directly are coated in a certain size, make the black plaster plaster.
(3) get fine powder and micropowder; the transdermal enhancer laurocapram of adding 30%; the substrate that adds 10 times of amounts again; substrate comprises PVAC polyvinylalcohol, glycerol, silica gel; its proportioning is 5: 2: 8, fully is mixed into paste, is coated on a certain size the lining cloth; the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.
Embodiment 1: get recipe quantity 10 times, water decocts 2 times, for the first time with 8 times of water gagings, decocts 2 hours, with 6 times of water gagings, decocted 2 hours for the second time, filter merging filtrate, being evaporated to relative density is 1.25, is cooled to room temperature, adds ethanol and makes that to contain the alcohol amount be 70%, stir evenly, leave standstill 12h and make precipitation, get supernatant and reclaim ethanol, be evaporated to relative density and be 1.40 thick paste, 65 ℃ of vacuum dryings, dry thing 2.7kg, pulverize, cross 100 mesh sieves, get powder 2.65kg.Add the Mel of 3 times of amounts, stir in the pasty state, add 20% Oleum sesami again, fully be mixed into paste, get 12.5kg, packing, every bag of 10g promptly gets ointment (per 10 gram ointment are equivalent to crude drug 10.8g).Or add the pressure-sensitive adhesive butyl acrylate mix homogeneously of 8 times of amounts, mastic 23.3kg, on 120 ℃ of lining cloth that directly are coated in a certain size, make black plaster plaster (per 10 gram mastic are equivalent to crude drug 5.8g).Or adding 30% the laurocapram and the substrate of 10 times of amounts, the proportioning of PVAC polyvinylalcohol, glycerol, silica gel is 5: 2: 8, fully is mixed into paste; get 28.5kg; be coated on a certain size the lining cloth, the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.(per 10 gram mastic are equivalent to crude drug 4.7g)
Embodiment 2: get recipe quantity 10 times, with 80% ethanol extraction 2 times, 8 times of amounts were extracted 1 hour for the first time, with 5 times of water gagings, extracted 1 hour for the second time, filter, collect filtrate, being evaporated to relative density is 1.15, is cooled to room temperature, the ethyl acetate extraction of 1 times of amount of adding 2 times, standing demix is got upper strata liquid and is reclaimed ethyl acetate, be evaporated to relative density and be 1.40 thick paste, 65 ℃ of vacuum dryings, dry thing 1.35kg, pulverize, cross 100 mesh sieves, get powder 1.32kg.Add the Mel of 3 times of amounts, stir in the pasty state, add 20% Oleum sesami again, fully be mixed into paste, get 6.2kg, packing, every bag of 10g promptly gets ointment (per 10 gram ointment are equivalent to crude drug 21.7g).Or add the pressure-sensitive adhesive butyl acrylate mix homogeneously of 8 times of amounts, mastic 11.88kg, on 120 ℃ of lining cloth that directly are coated in a certain size, make black plaster plaster (per 10 gram mastic are equivalent to crude drug 11.44g).Or adding 30% the laurocapram and the substrate of 10 times of amounts, the proportioning of PVAC polyvinylalcohol, glycerol, silica gel is 5: 2: 8, fully is mixed into paste; get 14.52kg; be coated on a certain size the lining cloth, the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.(per 10 gram mastic are equivalent to crude drug 9.3g)
Embodiment 3: get recipe quantity 10 times, micronizing becomes the micropowder of particle diameter≤10 micron on ultrafine crusher, 12.6kg.Add the Mel of 3 times of amounts, stir in the pasty state, add 20% Oleum sesami again, fully be mixed into paste, get 59.3kg, packing, every bag of 10g promptly gets ointment (per 10 gram ointment are equivalent to crude drug 2.27g).Or add the pressure-sensitive adhesive butyl acrylate mix homogeneously of 8 times of amounts, mastic 111.1kg, on 120 ℃ of lining cloth that directly are coated in a certain size, make black plaster plaster (per 10 gram mastic are equivalent to crude drug 1.22g).Or the laurocapram of adding 30% and the substrate of 10 times of amounts; the proportioning of PVAC polyvinylalcohol, glycerol, silica gel is 5: 2: 8; fully be mixed into paste; get 135.8kg; be coated on a certain size the lining cloth; the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.(per 10 gram mastic are equivalent to crude drug 1.0g)
Claims (15)
1, a kind of 'Xue Fu Zhu Yu ' ointment, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae are raw material, it is characterized in that choosing: the extract of Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% or its micropowder are active component, with Mel, Oleum sesami is substrate, and the proportioning of said extracted thing or its micropowder, Mel, Oleum sesami is: 1: 2-4: 0.1-0.3.
2, 'Xue Fu Zhu Yu ' ointment according to claim 1, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae is a raw material, it is characterized in that choosing: Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, the extract of Radix Glycyrrhizae 1-4% or its micropowder are active component, with Mel, Oleum sesami is substrate, said extracted thing or its micropowder, Mel, the optimum ratio of Oleum sesami is: 1: 3: 0.2.
3, 'Xue Fu Zhu Yu ' ointment according to claim 1 and 2, it is characterized in that: preparation method is got Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae waters decoct 1-3 time, water consumption 6-10 doubly, each 1-3h, filter, collect filtrate, being evaporated to relative density is 1.10-1.30, be cooled to room temperature, add ethanol and make and contain the alcohol amount and be 70-80%, stir evenly, leave standstill 8-24h and make precipitation, get supernatant and reclaim ethanol, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder, add the Mel that 2-4 doubly measures, stir in the pasty state, add the Oleum sesami of 0.1-0.3 again, fully be mixed into paste, packing promptly gets ointment.
4, 'Xue Fu Zhu Yu ' ointment according to claim 1 and 2, it is characterized in that: preparation method is got Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae are with 80% ethanol extraction 1-2 time, with alcohol amount 5-8 doubly, each 0.5-2h, filter, collect filtrate, being evaporated to relative density is 1.10-1.20, be cooled to room temperature, the ethyl acetate extraction that adding 1-3 doubly measures 2-3 time, get supernatant and reclaim ethyl acetate, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder, add the Mel that 2-4 doubly measures, stir in the pasty state, add the Oleum sesami of 0.1-0.3 again, fully be mixed into paste, packing promptly gets ointment.
5, 'Xue Fu Zhu Yu ' ointment according to claim 1 and 2 is characterized in that: preparation method is got the micropowder that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae micronizing on ultrafine crusher become particle diameter≤10 micron;
Get micropowder, add the Mel that 2-4 doubly measures, stir in the pasty state, add the Oleum sesami of 0.1-0.3 again, fully be mixed into paste, packing promptly gets ointment.
6, a kind of 'Xue Fu Zhu Yu ' plaster, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae are raw material, it is characterized in that choosing: the extract of Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% or its micropowder are active component, with the pressure-sensitive adhesive is substrate, and the proportioning of said extracted thing or its micropowder and pressure-sensitive adhesive is: 1: 1-10.
7, 'Xue Fu Zhu Yu ' plaster according to claim 6, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae is a raw material, it is characterized in that choosing: Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, the extract of Radix Glycyrrhizae 1-4% or its micropowder are active component, with the pressure-sensitive adhesive is substrate, and the proportioning of said extracted thing or its micropowder and pressure-sensitive adhesive is: 1: 8.
8, according to claim 6 or 7 described 'Xue Fu Zhu Yu ' plaster, it is characterized in that: preparation method is got Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae waters decoct 1-3 time, water consumption 6-10 doubly, each 1-3h, filter, collect filtrate, being evaporated to relative density is 1.10-1.30, be cooled to room temperature, add ethanol and make and contain the alcohol amount and be 70-80%, stir evenly, leave standstill 8-24h and make precipitation, get supernatant and reclaim ethanol, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder and add the pressure-sensitive adhesive that 1-10 doubly measures, comprise one or more mixture such as butyl acrylate, acrylic acid-2-ethyl caproite, glycidyl methacrylate, acrylic acid, with powder and pressure-sensitive adhesive mix homogeneously, on 80-120 ℃ of lining cloth that directly is coated in a certain size, make the black plaster plaster.
9, according to claim 6 or 7 described 'Xue Fu Zhu Yu ' plaster, it is characterized in that: preparation method is got Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae are with 80% ethanol extraction 1-2 time, with alcohol amount 5-8 doubly, each 0.5-2h, filter, collect filtrate, being evaporated to relative density is 1.10-1.20, be cooled to room temperature, the ethyl acetate extraction that adding 1-3 doubly measures 2-3 time, get supernatant and reclaim ethyl acetate, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder, add the pressure-sensitive adhesive that 1-10 doubly measures, comprise one or more mixture such as butyl acrylate, acrylic acid-2-ethyl caproite, glycidyl methacrylate, acrylic acid, with powder and pressure-sensitive adhesive mix homogeneously, on 80-120 ℃ of lining cloth that directly is coated in a certain size, make the black plaster plaster.
10, according to claim 6 or 7 described 'Xue Fu Zhu Yu ' plaster, it is characterized in that: preparation method is got the micropowder that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae micronizing on ultrafine crusher become particle diameter≤10 micron;
Get micropowder, add the pressure-sensitive adhesive that 1-10 doubly measures, comprise one or more mixture such as butyl acrylate, acrylic acid-2-ethyl caproite, glycidyl methacrylate, acrylic acid, with powder and pressure-sensitive adhesive mix homogeneously, on 80-120 ℃ of lining cloth that directly is coated in a certain size, make the black plaster plaster.
11, a kind of 'Xue Fu Zhu Yu ' cataplasma, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae is a raw material, it is characterized in that choosing: Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, the extract of Radix Glycyrrhizae 1-4% or its micropowder are active component, the transdermal enhancer laurocapram that adds 10%-30%, propylene glycol or both mixture, add the substrate that 1-10 doubly measures again, substrate comprises adhesive, wetting agent, filler, its proportioning are 1-5: 1-2.5: 1-8.
12, 'Xue Fu Zhu Yu ' cataplasma according to claim 11, adopt: Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Radix Platycodonis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Glycyrrhizae is a raw material, it is characterized in that choosing: Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, the extract of Radix Glycyrrhizae 1-4% or its micropowder are active component, optimum ratio is: the transdermal enhancer laurocapram of adding 30%, the substrate that adds 10 times of amounts again, substrate comprises PVAC polyvinylalcohol, glycerol, silica gel, its proportioning are 5: 2: 8.
13, according to claim 11 or 12 described 'Xue Fu Zhu Yu ' cataplasmas, it is characterized in that: preparation method is got Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae waters decoct 1-3 time, water consumption 6-10 doubly, each 1-3h, filter, collect filtrate, being evaporated to relative density is 1.10-1.30, be cooled to room temperature, add ethanol and make and contain the alcohol amount and be 70-80%, stir evenly, leave standstill 8-24h and make precipitation, get supernatant and reclaim ethanol, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder and micropowder, the transdermal enhancer laurocapram, propylene glycol or both mixture that add 10%-30%, add the substrate that 1-10 doubly measures again, substrate comprises adhesive, wetting agent, filler, its proportioning is 1-5: 1-2.5: 1-8, and wherein adhesive comprises sodium polyacrylate, sodium carboxymethyl cellulose, polyvinyl alcohol, methylcellulose, gelatin etc.; Wetting agent comprises glycerol, Polyethylene Glycol, sorbitol, glycerol etc.; Filler comprises silica gel, calcium carbonate, Bentonite, zinc oxide etc., and powder and substrate fully are mixed into paste, is coated on a certain size the lining cloth, and the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.
14, according to claim 11 or 12 described 'Xue Fu Zhu Yu ' cataplasmas, it is characterized in that: preparation method is got Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae are with 80% ethanol extraction 1-2 time, with alcohol amount 5-8 doubly, each 0.5-2h, filter, collect filtrate, being evaporated to relative density is 1.10-1.20, be cooled to room temperature, the ethyl acetate extraction that adding 1-3 doubly measures 2-3 time, get supernatant and reclaim ethyl acetate, be evaporated to the thick paste that relative density is 1.30-1.40, vacuum drying 60-80 ℃, get dry thing, pulverize, cross the 80-100 mesh sieve;
Get fine powder and micropowder, the transdermal enhancer laurocapram, propylene glycol or both mixture that add 10%-30%, add the substrate that 1-10 doubly measures again, substrate comprises adhesive, wetting agent, filler, its proportioning is 1-5: 1-2.5: 1-8, and wherein adhesive comprises sodium polyacrylate, sodium carboxymethyl cellulose, polyvinyl alcohol, methylcellulose, gelatin etc.; Wetting agent comprises glycerol, Polyethylene Glycol, sorbitol, glycerol etc.; Filler comprises silica gel, calcium carbonate, Bentonite, zinc oxide etc., and powder and substrate fully are mixed into paste, is coated on a certain size the lining cloth, and the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.
15, according to claim 11 or 12 described 'Xue Fu Zhu Yu ' cataplasmas, it is characterized in that: preparation method is got the micropowder that Radix Angelicae Sinensis 1-12%, Semen Persicae 1-16%, Flos Carthami 1-12%, Radix Achyranthis Bidentatae 1-12%, Radix Rehmanniae 1-12%, Radix Paeoniae Rubra 1-8%, Fructus Aurantii 1-8%, Radix Platycodonis 1-6%, Rhizoma Chuanxiong 1-6%, Radix Bupleuri 1-4%, Radix Glycyrrhizae 1-4% ten Herba indigoferae Pseudotinctoriae micronizing on ultrafine crusher become particle diameter≤10 micron;
Get fine powder and micropowder, the transdermal enhancer laurocapram, propylene glycol or both mixture that add 10%-30%, add the substrate that 1-10 doubly measures again, substrate comprises adhesive, wetting agent, filler, its proportioning is 1-5: 1-2.5: 1-8, and wherein adhesive comprises sodium polyacrylate, sodium carboxymethyl cellulose, polyvinyl alcohol, methylcellulose, gelatin etc.; Wetting agent comprises glycerol, Polyethylene Glycol, sorbitol, glycerol etc.; Filler comprises silica gel, calcium carbonate, Bentonite, zinc oxide etc., and powder and substrate fully are mixed into paste, is coated on a certain size the lining cloth, and the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670832A (en) * | 2012-05-29 | 2012-09-19 | 王新 | Chinese medicine for treating costal chondritis |
| CN103083490A (en) * | 2013-02-18 | 2013-05-08 | 柳少逸 | Traditional Chinese medicine for treating post-traumatic brain syndrome |
| CN108210662A (en) * | 2018-03-29 | 2018-06-29 | 张峰 | A kind of reunion of bone, traditional Chinese medicine plaster promoting blood circulation and removing blood stasis, swelling and pain relieving |
| CN110449057A (en) * | 2019-08-09 | 2019-11-15 | 青岛农业大学 | A kind of pet paste, preparation method and its preparation facilities |
-
2005
- 2005-11-29 CN CNB2005100164623A patent/CN100560103C/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670832A (en) * | 2012-05-29 | 2012-09-19 | 王新 | Chinese medicine for treating costal chondritis |
| CN103083490A (en) * | 2013-02-18 | 2013-05-08 | 柳少逸 | Traditional Chinese medicine for treating post-traumatic brain syndrome |
| CN108210662A (en) * | 2018-03-29 | 2018-06-29 | 张峰 | A kind of reunion of bone, traditional Chinese medicine plaster promoting blood circulation and removing blood stasis, swelling and pain relieving |
| CN110449057A (en) * | 2019-08-09 | 2019-11-15 | 青岛农业大学 | A kind of pet paste, preparation method and its preparation facilities |
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| CN100560103C (en) | 2009-11-18 |
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