CN101199700A - Medicament for treating myocardial infarction - Google Patents
Medicament for treating myocardial infarction Download PDFInfo
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- CN101199700A CN101199700A CNA2006101302930A CN200610130293A CN101199700A CN 101199700 A CN101199700 A CN 101199700A CN A2006101302930 A CNA2006101302930 A CN A2006101302930A CN 200610130293 A CN200610130293 A CN 200610130293A CN 101199700 A CN101199700 A CN 101199700A
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Abstract
The invention discloses a medicine ointment for treating myocardial infarction. The poultice of the invention is an external-use compound paste preparation which is refined by main 11 drugs as effective ingredients; the drugs contain Pollen Typhae, Radix Paeoniae Alba, Fructus Trichosanthis, Ramulus Cinnamomi, Rhizoma Pinelliae, Semen Persicae, Flos Carthami, Faeces Trogopterori, Radix Notoginseng and Succinum. The invention has evident effect on treating thrombus and myocardial infarction. The paste body of the poultice is fine, soft and smooth, easy to be coated on cloth and uneasy to melt, easy for carrying and using because of small size and good for quick recovery of the focuses. The poultice has stable drug property and has the characteristics of quick percutaneous absorption, good ventilation property and gradual drug releasing. Compared with the oral preparation, the invention has the advantages of no liver-intestines first-filter action, no influence from gastrointestinal degradation and high bioavailability. Compared with injection, the invention has the advantages of convenient use and no pain. Compared with ointment, the invention has the advantages of accurate dose and fixed absorption area. Compared with black plaster and sticking plaster, the invention has the advantages of no sensibility on skin, no pollution to clothes, long effect, percutaneous absorption and convenient carrying and use.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, particularly relate to a kind of medicine for the treatment of myocardial infarction.
Background technology
Blood fat, hypercholesterolemia be the thrombosis that causes and produce disease principal element such as myocardial infarction, and treatment and pre-preventing thrombosis and produce myocardial infarction and start with from blood fat reducing, cholesterol have a kind of classical Chinese patent medicine, Ministry of Public Health standard WS at present
2-B-0928-91 record XUEFU ZHUYU JIAONANG prescription:
Semen Persicae (stir-fry) 200g Radix Angelicae Sinensis 150g Fructus Aurantii (parched with bran) 100g Rhizoma Chuanxiong 75g Radix Bupleuri 50g
Flos Carthami 150g Radix Achyranthis Bidentatae 150g Radix Paeoniae Rubra 100g Radix Rehmanniae 150g Radix Platycodonis 75g Radix Glycyrrhizae 50g
Function with cure mainly: blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.Be used for blood-stasis internal-depression, chest pain or headache, interior-heat blurring of vision accompanied with oppressive feeling, insomnia and dreamful sleep, severe palpitation, impatience and irascibility.
Preparation technology: Semen Persicae 100g, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Fructus Aurantii, Rhizoma Chuanxiong, Radix Bupleuri are ground into fine powder, sieve, mixing, the five tastes such as all the other Flos Carthamis and Semen Persicae 100g decoct with water three times, filter merging filtrate, being condensed into relative density is the thick paste of 1.15～1.25 (65～70 ℃), with above-mentioned powder mixing, make granule, oven dry, pulverize, sieve, encapsulated, promptly.
Other has applying date 2001.1.5, the patent record prescription of publication number CN1362075A " nano blood stasis dispersing preparation medicine and preparation method thereof ":
Nanometer Semen Persicae 10-50 part nano Chinese angelica 8-60 part nanometer Fructus Aurantii 10-70 part nanometer Rhizoma Chuanxiong 8-60 part
Nano bupleurum 10-60 part nano safflower 8-60 part nanometer Radix Achyranthis Bidentatae 8-50 part nanometer Radix Paeoniae Rubra 8-60 part
Nanometer Radix Rehmanniae 10-60 part nanometer Radix Platycodonis 5-50 part nanometer Radix Glycyrrhizae 5-30 part
Function with cure mainly: can be used for treatment of conditions such as headache, dizzy, brain injury sequela, angina pectoris.
Pharmacology and Clinics of Chinese Materia Medica, 1990,6 (6), the 1-4 page or leaf, Peng Kang, Zheng Youshun work " side's of tearing open research of decoction for removing blood stasis---to microcirculatory pharmacological action " prove can microcirculation improvement, and the hypertension that causes because of the increase of blood capillary resistance is had certain inhibitory action.The medicine of treatment myocardial infarction is many does not at present regard sb. as an outsider as yet and uses preparation with oral formulations is arranged, and the oral treatment cycle that exists is long, also has bigger problems such as toxic and side effects.
Summary of the invention
The purpose of this invention is to provide the high promoting blood circulation to restore menstrual flow of a kind of bioavailability, the unguentum of the external of eliminating stasis to stop pain, but the cataplasma that comprises the ointment machin controlled release drug administration, make its treatment myocardial infarction etc. in the symptom performance absorb advantage fast, instant effect, more can directly contact focus, and the medicine patch of treatment myocardial infarction easy to use.
In order to reach purpose of the present invention, we select to have hemostasis, blood stasis dispelling, the Pollen Tyjphae for the treatment of stranguria effect has stasis-dispelling and pain-killing, Huo Xue Tong Network, the Radix Salviae Miltiorrhizae of the relieving restlessness effect that clears away heart-fire, has suppressing liver-YANG, the yin fluid astringing that nourishes blood, the Radix Paeoniae Alba of easing the affected liver to relieve pain effect, has removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens is moisturized the Fructus Trichosanthis of laxation effect, has heating and induces sweat the Ramulus Cinnamomi of warming the meridian for promoting the flow of YANG QI effect, has drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the Rhizoma Pinelliae of the tired mass-dissipating efficacy that disappears, Semen Persicae with tranquilizing by nourishing the heart effect, has promoting blood circulation to restore menstrual flow, the Flos Carthami of eliminating stasis to stop pain effect has promoting blood circulation and stopping pain, removing stasis to stop bleeding, the Oletum Trogopterori of removing food stagnancy detoxicating functions, have the dissipating blood stasis hemostasis, the Radix Notoginseng of subduing swelling and relieving pain effect has tranquillizing the mind by relieving convulsion, the dissipating blood stasis hemostasis, relieving stranguria by diuresis makes eye bright the raw materials such as succinum of effect as effective ingredient, the invention provides a kind of medicine for the treatment of myocardial infarction, it is characterized in that the effective ingredient that makes this medicine is made up of following materials of weight proportions:
Pollen Tyjphae 14g～25g Radix Salviae Miltiorrhizae 14g～25g Radix Paeoniae Alba 14g～25g Fructus Trichosanthis 14g～25g
Ramulus Cinnamomi 7g～11g Rhizoma Pinelliae 7g～11g Semen Persicae 7g～11g Flos Carthami 7g～11g
Oletum Trogopterori 7g～11g Radix Notoginseng 2g～4g succinum 2g～4g.
The medicine of described treatment myocardial infarction is characterized in that the effective ingredient that makes this medicine is made up of following materials of weight proportions:
Pollen Tyjphae 15g Radix Salviae Miltiorrhizae 15g Radix Paeoniae Alba 15g Fructus Trichosanthis 15g Ramulus Cinnamomi 9g Rhizoma Pinelliae 9g
Semen Persicae 9g Flos Carthami 9g Oletum Trogopterori 9g Radix Notoginseng 3g succinum 3g.
The medicine of described treatment myocardial infarction, it is characterized in that described medicine be externally used paste it be to be prepared from by following processing step:
A, extraction process:
A, with Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Fructus Trichosanthis, Ramulus Cinnamomi, the Rhizoma Pinelliae, Semen Persicae, Flos Carthami, Oletum Trogopterori, Radix Notoginseng, succinum medicinal material coarse powder 30 orders, input adds in the percolation jar of Vltrasonic device, add a cover after stirring with medical material equivalent solvent 90% ethanol, make its moistening and the 1～4h that expands, dynamic ultrasound device control percolation flow velocity is 1～3ml/min, at any time add solvent to percolate colourless, tasteless till, drying, temperature limit is below 60 ℃;
B, just the Pollen Tyjphae medical material is packed with cloth bag, decocts twice, and amount of water is 4～8 times, and decocting time 1～3h merges filtrate twice; Filtrate decompression being concentrated into relative density is 1.05～1.30 again, the clear paste of 50～85 ℃ of mensuration, add ethanol while stirring and reach 60～80% to containing the alcohol amount, after fully stirring, left standstill 10～46 hours, and collected supernatant, reclaim ethanol, being evaporated to relative density is the clear paste of 1.05～1.30,50～85 ℃ of mensuration; 60 ℃ of dryings, it is standby to beat powder 100 orders;
C, get the micropowder that above-mentioned medicated powder micronizing on ultrafine crusher becomes particle diameter 200 μ m;
B, preparations shaping technology:
The micropowder that obtains in the said extracted technology all can adopt following method to make ointment and cataplasma, and concrete grammar is as follows:
(a) get micropowder, add the Mel of 2～4 times of amounts, the pasty state that stirs adds 10～30% Oleum sesami again, fully is mixed into paste, and packing promptly gets ointment; Per 10 gram ointment are equivalent to crude drug 2.0～22.8g;
(b) get fine powder and micropowder, add the substrate that 1-10 doubly measures, substrate comprises adhesive, wetting agent, filler, and its proportioning is 1～5: 1～2.5: 1～8, and wherein adhesive comprises sodium polyacrylate, sodium carboxymethyl cellulose, polyvinyl alcohol, methylcellulose, gelatin etc.; Wetting agent comprises glycerol, Polyethylene Glycol, sorbitol, glycerol etc.; Filler comprises silica gel, calcium carbonate, Bentonite, zinc oxide etc., and powder and substrate fully are mixed into paste, is coated on a certain size the lining cloth, and the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher; Per 10 gram mastic are equivalent to crude drug 1.0～10.0g.
Invention effect: 1, the preparation method of above-mentioned Pollen Tyjphae extract, this process using water extracting alcohol changes molten method, macromole impurity such as starch, crude protein, crude fat have been removed, not only keep most of water solublity and liposoluble constituent and (mostly be the flavonoid active component, comprise that mainly it is the glycosides derivative of parent nucleus that quercetin, isorhamnetin, kaempferol reach with it), and technology is simple, is easier to operation and popularization in big production; Active ingredient made full use of during Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Fructus Trichosanthis, Ramulus Cinnamomi, the Rhizoma Pinelliae, Semen Persicae, Flos Carthami, Oletum Trogopterori, Radix Notoginseng, succinum medical material all will be write out a prescription effectively with the percolation extraction process, and be purified by effective technology of preparing, results of pharmacodynamic test shows, effect with blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, as blood fat, the hypercholesterolemia of external preparation to causing owing to a variety of causes, treatment of diseases such as the thrombosis of generation and myocardial infarction and preventive effect are remarkable.
2, above-mentioned two kinds of preparations shaping technologies are external, to skin nonirritant, stable in properties.Wherein ointment mastic exquisiteness, soft and smooth, be easy to coating and do not melt, volume is little, and is easy to use and carry, being beneficial to focus recovers fast; The pharmaceutical properties of cataplasma is stable, has that Transdermal absorption is fast, good permeability and characteristics such as release progressively, compares with peroral dosage form, no liver sausage first-pass effect is not subjected to the gastrointestinal tract degraded to influence the bioavailability height, compare with injection, easy to use, no pain is compared with ointment, dosage is accurate, absorption area is fixed, and compares the phenomenon of no skin allergy and pollution clothes with black plaster, rubber plaster.
3, the superfine technique smashing fineness can reach 200 μ m, can keep on the basis of effective ingredient 95%, and the cell wall breaking rate of Chinese crude drug up to more than 99%, is guaranteed that active constituents of medicine is not destroyed, and cost is low.
The specific embodiment
Embodiment 1: the medicine (trade name: the myocardial infarction unguentum) of treatment myocardial infarction
Prescription:
Pollen Typhae 150g Radix Salviae Miltiorrhizae 150g Radix Paeoniae Alba 150g Fructus Trichosanthis 150g Ramulus Cinnamomi 90g Rhizoma Pinelliae 90g
Semen Persicae 90g Flos Carthami 90g Oletum Trogopterori 90g Radix Notoginseng 30g succinum 30g
Preparation method:
A, extraction process:
(a) with Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Fructus Trichosanthis, Ramulus Cinnamomi, the Rhizoma Pinelliae, Semen Persicae, Flos Carthami, Oletum Trogopterori, Radix Notoginseng, succinum medicinal material coarse powder 30 orders, input adds in the percolation jar of Vltrasonic device, add a cover after stirring with medical material equivalent solvent 90% ethanol, make its moistening and the 1～4h that expands, dynamic ultrasound device control percolation flow velocity is 1～3ml/min, at any time add solvent to percolate colourless, tasteless till, drying, temperature limit is below 60 ℃;
(b) the Pollen Tyjphae medical material is packed with cloth bag, decocted twice, add 7 times of water gagings for the first time, decoct 2h, collect filtrate; Add for the second time 5 times of water gagings, decoct 1h, collect filtrate, merge filtrate twice.Again filtrate decompression is concentrated into the clear paste that relative density is 1.10,60 ℃ of mensuration, adds ethanol while stirring and reach 80%, after fully stirring, leave standstill 24h, collect supernatant, reclaim ethanol, be evaporated to the clear paste that relative density is 1.15,60 ℃ of mensuration to containing the alcohol amount.60 ℃ of dryings, it is standby to beat powder 100 orders;
(c) get the micropowder that above-mentioned medicated powder micronizing on ultrafine crusher becomes particle diameter 200 μ m;
B, preparations shaping technology:
The micropowder that obtains in the said extracted technology all can adopt following method to make ointment, and concrete grammar is as follows:
Get micropowder, add the Mel of 3 times of amounts, the pasty state that stirs adds 20% Oleum sesami again, fully is mixed into paste, packing, and every bag of 10g promptly gets ointment (per 10 gram ointment are equivalent to crude drug 10.8g).
Embodiment 2: the medicine (trade name: the myocardial infarction cataplasma) of treatment myocardial infarction
Prescription:
Pollen Typhae 150g Radix Salviae Miltiorrhizae 150g Radix Paeoniae Alba 150g Fructus Trichosanthis 150g Ramulus Cinnamomi 90g Rhizoma Pinelliae 90g
Semen Persicae 90g Flos Carthami 90g Oletum Trogopterori 90g Radix Notoginseng 30g succinum 30g
Preparation method:
A, extraction process:
(a) with Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Fructus Trichosanthis, Ramulus Cinnamomi, the Rhizoma Pinelliae, Semen Persicae, Flos Carthami, Oletum Trogopterori, Radix Notoginseng, succinum medicinal material coarse powder 30 orders, input adds in the percolation jar of Vltrasonic device, add a cover after stirring with medical material equivalent solvent 90% ethanol, make its moistening and the 1～4h that expands, dynamic ultrasound device control percolation flow velocity is 1～3ml/min, at any time add solvent to percolate colourless, tasteless till, drying, temperature limit is below 60 ℃;
(b) the Pollen Tyjphae medical material is packed with cloth bag, decocted twice, add 7 times of water gagings for the first time, decoct 2h, collect filtrate; Add for the second time 5 times of water gagings, decoct 1h, collect filtrate, merge filtrate twice.Again filtrate decompression is concentrated into the clear paste that relative density is 1.10,60 ℃ of mensuration, adds ethanol while stirring and reach 80%, after fully stirring, leave standstill 24h, collect supernatant, reclaim ethanol, be evaporated to the clear paste that relative density is 1.15,60 ℃ of mensuration to containing the alcohol amount.60 ℃ of dryings, it is standby to beat powder 100 orders;
(c) get the micropowder that above-mentioned medicated powder micronizing on ultrafine crusher becomes particle diameter 200 μ m;
B, preparations shaping technology:
The micropowder that obtains in the said extracted technology all can adopt following method to make soft cataplasma, and concrete grammar is as follows:
Get micropowder; or add the substrate of 8 times of amounts; the proportioning of PVAC polyvinylalcohol, glycerol, silica gel is 5: 2: 8; fully being mixed into paste is coated on a certain size the lining cloth; the protective film that mastic surface coverage layer of polyethylene is made; promptly get the cataplasma for the treatment of myocardial infarction, (per 10 gram mastic are equivalent to crude drug 4.7g).
Embodiment 3: the medicine patch unguentum study on the stability of treatment myocardial infarction
In " specification requirement of study of tcm new drug " promulgated and enforced according to National Drug Administration, the specification requirement of new Chinese medicine steady quality Journal of Sex Research regulation.Make anginal ointment of treatment and cataplasma by formulating technology, under the room temperature character, moisture retention, content and microbiological examination project are observed.The result shows: every detection index meets national unguentum quality standard, and room temperature was placed six months, steady quality.
Embodiment 4: the pharmacodynamics test data of the medicine patch of treatment myocardial infarction:
1. test objective: ointment, the cataplasma of treatment myocardial infarction is the refining compound external-use unguentum that forms of effective ingredient medical material by 11 flavor medical material conducts such as Pollen Typhae, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Fructus Trichosanthis, Ramulus Cinnamomi, the Rhizoma Pinelliae, Semen Persicae, Flos Carthami, Oletum Trogopterori, Radix Notoginseng, succinum, has promoting blood circulation to restore menstrual flow, the effect of eliminating stasis to stop pain.
The test of pesticide effectiveness:
1. test objective:
Observe the treatment myocardial infarction medicine (trade name: the myocardial infarction cataplasma) sample repeatedly transdermal administration to influence by hyperlipidemia rats due to the high lipid food.
2. trial drug:
The myocardial infarction cataplasma: the Tianjin Zhongbao Pharm. Co., Ltd provides
High lipid food: Tianjin medical sci-tech institute preparation
3. experimental animal:
Rat: the Wistar kind, body weight 200-250g, the male and female dual-purpose, medical sci-tech institute animal housing provides by Tianjin.
4. conclusion (of pressure testing):
Result of the test shows that myocardial infarction cataplasma sample sets has tangible reduction effect to serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL), simultaneously HDL-C (HDL) is had tangible rising effect.The result shows that the bioavailability of myocardial infarction cataplasma is higher, has rapid-actionly, and toxic and side effects is little; There is not bad abnormal smells from the patient, easy to carry.Function cures mainly: blood fat reducing, being used for the treatment of diseases such as thrombosis that blood fat, hypercholesterolemia disease cause and myocardial infarction has significant curative effect.
Claims (3)
1. the medicine of treatment myocardial infarction is characterized in that the effective ingredient that makes this medicine is made up of following materials of weight proportions:
Pollen Tyjphae 14g～25g Radix Salviae Miltiorrhizae 14g～25g Radix Paeoniae Alba 14g～25g Fructus Trichosanthis 14g～25g
Ramulus Cinnamomi 7g～11g Rhizoma Pinelliae 7g～11g Semen Persicae 7g～11g Flos Carthami 7g～11g
Oletum Trogopterori 7g～11g Radix Notoginseng 2g～4g succinum 2g～4g.
2. the medicine of treatment myocardial infarction according to claim 1,, it is characterized in that the effective ingredient that makes this medicine is made up of following materials of weight proportions:
Pollen Typhae 15g Radix Salviae Miltiorrhizae 15g Radix Paeoniae Alba 15g Fructus Trichosanthis 15g Ramulus Cinnamomi 9g Rhizoma Pinelliae 9g
Semen Persicae 9g Flos Carthami 9g Oletum Trogopterori 9g Radix Notoginseng 3g succinum 3g.
3. the medicine of treatment myocardial infarction according to claim 1 and 2, it is characterized in that described medicine be externally used paste it be to be prepared from by following processing step:
A, extraction process:
(a) with Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Fructus Trichosanthis, Ramulus Cinnamomi, the Rhizoma Pinelliae, Semen Persicae, Flos Carthami, Oletum Trogopterori, Radix Notoginseng, succinum medicinal material coarse powder 30 orders, input adds in the percolation jar of Vltrasonic device, add a cover after stirring with medical material equivalent solvent 90% ethanol, make its moistening and the 1～4h that expands, dynamic ultrasound device control percolation flow velocity is 1～3ml/min, at any time add solvent to percolate colourless, tasteless till, drying, temperature limit is below 60 ℃;
(b) just the Pollen Tyjphae medical material is packed with cloth bag, decocts twice, and amount of water is 4～8 times, and decocting time 1～3h merges filtrate twice; Filtrate decompression being concentrated into relative density is 1.05～1.30 again, the clear paste of 50～85 ℃ of mensuration, add ethanol while stirring and reach 60～80%, after fully stirring, left standstill 10～46 hours to containing the alcohol amount, collect supernatant, reclaim ethanol, being evaporated to relative density is the clear paste of 1.05～1.30,50～85 ℃ of mensuration, 60 ℃ of dryings, it is standby to beat powder 100 orders;
(c) get the micropowder that above-mentioned medicated powder micronizing on ultrafine crusher becomes particle diameter 200 μ m;
B, preparations shaping technology:
The micropowder that obtains in the said extracted technology all can adopt following method to make ointment and cataplasma, and concrete grammar is as follows:
(a) get micropowder, add the Mel of 2～4 times of amounts, the pasty state that stirs adds 10～30% Oleum sesami again, fully is mixed into paste, and packing promptly gets ointment; Per 10 gram ointment are equivalent to crude drug 2.0～22.8g;
(b) get fine powder and micropowder, add the substrate that 1-10 doubly measures, substrate comprises adhesive, wetting agent, filler, and its proportioning is 1～5: 1～2.5: 1～8, and wherein adhesive comprises sodium polyacrylate, sodium carboxymethyl cellulose, polyvinyl alcohol, methylcellulose, gelatin etc.; Wetting agent comprises glycerol, Polyethylene Glycol, sorbitol, glycerol etc.; Filler comprises silica gel, calcium carbonate, Bentonite, zinc oxide etc., and powder and substrate fully are mixed into paste, is coated on a certain size the lining cloth, and the protective film that mastic surface coverage layer of polyethylene is made promptly gets Chinese medicine patcher; Per 10 gram mastic are equivalent to crude drug 1.0～10.0g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101302930A CN101199700A (en) | 2006-12-15 | 2006-12-15 | Medicament for treating myocardial infarction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101302930A CN101199700A (en) | 2006-12-15 | 2006-12-15 | Medicament for treating myocardial infarction |
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| Publication Number | Publication Date |
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| CN101199700A true CN101199700A (en) | 2008-06-18 |
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ID=39515183
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2006101302930A Pending CN101199700A (en) | 2006-12-15 | 2006-12-15 | Medicament for treating myocardial infarction |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108355028A (en) * | 2018-05-09 | 2018-08-03 | 陈竹涛 | A kind of Chinese medicine and preparation method thereof for treating myocardial infarction |
| CN113117046A (en) * | 2019-12-30 | 2021-07-16 | 睿特环中医药科技发展有限公司 | Thrombolytic Chinese medicinal composition and preparation method thereof |
-
2006
- 2006-12-15 CN CNA2006101302930A patent/CN101199700A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108355028A (en) * | 2018-05-09 | 2018-08-03 | 陈竹涛 | A kind of Chinese medicine and preparation method thereof for treating myocardial infarction |
| CN113117046A (en) * | 2019-12-30 | 2021-07-16 | 睿特环中医药科技发展有限公司 | Thrombolytic Chinese medicinal composition and preparation method thereof |
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Open date: 20080618 |