CN1813833B - Medicinal composition of chinese angelica and ligusticum wallichii and its preparing method - Google Patents
Medicinal composition of chinese angelica and ligusticum wallichii and its preparing method Download PDFInfo
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- CN1813833B CN1813833B CN 200510129906 CN200510129906A CN1813833B CN 1813833 B CN1813833 B CN 1813833B CN 200510129906 CN200510129906 CN 200510129906 CN 200510129906 A CN200510129906 A CN 200510129906A CN 1813833 B CN1813833 B CN 1813833B
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Abstract
The present invention relates to a medicine composition formed from Chinese angelica root and ligusticum root and its preparation method. The invented technical scheme includes the following steps: (1), using Chinese angelica root and ligusticum root as raw material, using steam to distil them and collect their volatile oil, then adopting the processes of decoction, macroporous resin adsorption and spray-drying to prepare water-soluble extract powder, combining volatile oil and water-soluble extract powder to obtain total extract; and (2), using said total extract as medicinal main material and adding medicinal auxiliary materials according to a certain ratio, and making them into soft capsule or dripping pills preparation.
Description
Technical field:
The invention belongs to technical field of Chinese medicines, particularly, the present invention relates to a kind of blood-activating stasis-removing kind herbal mixture-a kind of pharmaceutical composition and method for making of forming by Radix Angelicae Sinensis and Rhizoma Chuanxiong total extract thereof.
Background technology:
Radix Angelicae Sinensis and Rhizoma Chuanxiong prescription name " foshousan " come from " general Ji ability side ", are the agent of nourshing blood and promoting blood circulation.Side name foshousan, though be because of square medicine two flavors, so enrich blood invigorate blood circulation, blood-activating and qi-promoting, dizzy, headache in puerperal before the treatment tire, it is hemorrhage have difficult labour, retention of dead fetus etc., its action range, and often receive special effect, like the Fructus Citri Sarcodactylis of person's extraordinary power of getting what he wants, thus.Modern Chinese medicine with this side be classified as blood circulation promoting and blood stasis dispelling, hemostasis and pain-relieving class medicine is right.We use extremely wide clinically now, be mainly used in the following aspects: (1) is used for the card of blood deficiency; (2) be used for the card of blood stasis; (3), be the article that to use of treating blood disorders regulating menstruation with controlling married woman's menopathy.Disclosed Radix Angelicae Sinensis Rhizoma Chuanxiong method for distilling comprises ether extraction and supercritical extraction etc. after ether extraction, the ethanol seepage, and ether extraction needs in a large number with an organic solvent, be prone to cause environmental pollution; And operation is prone to danger; Though supercritical extraction is higher to oiliness composition extract yield contained in Radix Angelicae Sinensis and the Rhizoma Chuanxiong, needs to use special devices, and be unfavorable for the extraction of aqueous soluble active constituent in the two flavor medicines; Therefore apply and have certain degree of difficulty, be unfavorable for realizing large-scale production.
Summary of the invention:
The purpose of this invention is to provide a kind of confession pharmaceutical composition for oral administration and preparation method thereof clinically, specifically, is a kind of pharmaceutical composition of being made up of Radix Angelicae Sinensis and Rhizoma Chuanxiong and preparation method thereof
The pharmaceutical composition that provides of the present invention is characterized in that it is is raw material preparation total extract earlier with Radix Angelicae Sinensis and Rhizoma Chuanxiong, is equipped with a certain amount of pharmaceutic adjuvant with total extract again and makes the pharmaceutical preparation that forms by certain technology.Wherein related total extract comprises water solublity extract powder and volatile oil two parts.At first adopt steam distillation to extract the volatile oil composition, main effective ingredient is a phthalide-type, wherein contains 30%～70% ligustilide; And, mainly contain phenolic acids and alkaloids effective ingredient with spray-dried preparation extract powder after the separation and purification of decocting liquid, contain 3%～8% ferulic acid.Make total extract with this technology, extracting total recovery is 2%～2.5%, and the mass ratio of water solublity extract powder and volatile oil is 1～2: 1 in the total extract.
The total extract that the present invention makes has intactly been preserved water miscible sour phenols, alkaloids composition and volatile oil in Radix Angelicae Sinensis, the Rhizoma Chuanxiong crude drug; And keep the ratio between two parts preferably, can bring into play the pharmacological action of our blood circulation promoting and blood stasis dispelling, hemostasis and pain-relieving to greatest extent.
The pharmaceutical preparation that the present invention makes is oral Preparation, relates generally to soft capsule or drop pill, and preparation unit is every, and every contains total extract 10～100mg.
Ligustilide be among the we drug activity more by force but photodissociation and isomerization very easily take place extremely unsettled material, the present invention is through adding lucifuge agent and stabilizing agent, the effect duration significant prolongation of medicine in the pharmaceutical preparation prescription.
Compared with prior art, the present invention has following characteristics:
1. need not special installation, simple to operate, cost is low, is easy to industrialization;
2. extraction efficiency is high, and paste-forming rate is low, has kept the active component in former side's foshousan more all sidedly;
3. the medicine that makes is stable, and effect duration is long.
The inventor extracts this compound volatile oil with steam distillation technology earlier through systematic study, and the extraction of reuse decocting, the enrichment of macropore absorbent and drying process with atomizing make the water solublity dried cream powder, and have prepared the pharmaceutical composition that contains its total extract.
The specific embodiment:
1. the preparation of total extract
A. be that 30%～70% Radix Angelicae Sinensis and 30%～70% Rhizoma Chuanxiong pulverizing medicinal materials are crossed 20 mesh sieves with weight ratio, add the water of 8～12 times of volumes, steam distillation 3～8 hours; Collect volatile oil with volatile oil extractor simultaneously; Oil reservoir is used a small amount of petroleum ether dissolution, and 40 ℃ of water-soluble petroleum ether that go get volatile oil.
B. the centrifugal 15min of decocting liquid 3000rpm collects supernatant and residue, and residue adds the water reflux, extract, 0.5～4 hour of 8～12 times of volumes again, again with the centrifugal 15min of decocting liquid 3000rpm, collects supernatant, merges supernatant twice, the water-soluble portion extracting solution.
C. water-soluble extracting liquid adopts the D101 macroporous resin adsorption; Calculate resin demand by 0.5～0.8ml resin/g decoction pieces; 0.5～2.0 times of resin volume of flow velocity during absorption/hour, the ethanol of reuse 50%～95% with 0.4～2 times of resin volume/hour flow velocity be eluted to terminal point, collect eluent.
D. eluent filters, and 70 ℃ of vacuum concentration to ethanol are removed basically, and the concentrated solution spray drying gets the water-soluble portion extract powder.The spray drying condition is: Tokyo physics and chemistry Spray Dryer SD1000 spray drying appearance, air velocity 0.65m
3/ min, air pressure 18 * 10Kpa, 110 ℃ of inlet temperatures, 70 ℃ of outlet temperatures, 4 units of mixing speed, 1 unit of flow velocity, Clean after every 1 minute.
2. the preparation of preparation
The inventor is prepared into soft capsule with total extract, and concrete grammar is following:
A. get gelatin, glycerol, simple syrup, purified water mixing, add methyl hydroxybenzoate and nipagin A, add the titanium dioxide of pulverizing 180 mesh sieves again; Abundant mixing; Stir, the degassing, 60～80 ℃ are incubated 30 minutes; The glue of heat is pounced on the glass plate of cleaning, just can be obtained elasticity film preferably after the cooling.
B. with PEG400 and Macrogol 600 with 2: 1 volume mixture; Be heated to 40～80 ℃, add water solublity dried cream powder, 4%PEG6000,1% stabilizing agent, described stabilizing agent and be a kind of in fatsoluble vitamin class, the water-soluble vitamins, 8% glycerol and 8% tween 80; Add volatile oil again; Fully stir the back and cross colloid mill, the degassing, subsequent use.
C. the medicinal liquid that between two-layer film, adds quantitative and even. place in the steel mould and suppress, get final product soft capsule.
Make total extract through this technology of check, extracting total recovery is 2%～2.5%, and the mass ratio of water solublity extract powder and volatile oil is 1～2: 1 in the total extract.Intactly preserve water miscible sour phenols, alkaloids composition and volatile oil in Radix Angelicae Sinensis, the Rhizoma Chuanxiong crude drug, and kept the ratio between two parts preferably, can bring into play the pharmacological action of our blood circulation promoting and blood stasis dispelling, hemostasis and pain-relieving to greatest extent.
Claims (2)
1. preparation of drug combination method of processing by Radix Angelicae Sinensis and Rhizoma Chuanxiong; By Radix Angelicae Sinensis and the Rhizoma Chuanxiong prepared slices of Chinese crude drugs extract, the effective ingredient of separation and purification; Prepare total extract, and be mixed with oral solid formulation with other pharmaceutic adjuvants, it is characterized in that: method for preparing is following:
A. be that 30%～70% Radix Angelicae Sinensis and 30%～70% Rhizoma Chuanxiong pulverizing medicinal materials are crossed 20 mesh sieves with weight ratio, add the water of 8～12 times of volumes, steam distillation 3～8 hours; Collect volatile oil with volatile oil extractor simultaneously; Oil reservoir is used a small amount of petroleum ether dissolution, and 40 ℃ of water-soluble petroleum ether that go get volatile oil;
B. the centrifugal 15min of decocting liquid 3000rpm collects supernatant and residue, and residue adds the water reflux, extract, 0.5～4 hour of 8～12 times of volumes again, again with the centrifugal 15min of decocting liquid 3000rpm, collects supernatant, merges supernatant twice, the water-soluble portion extracting solution;
C. water-soluble extracting liquid adopts the D101 macroporous resin adsorption; Calculate resin demand by 0.5～0.8ml resin/g decoction pieces; 0.5～2.0 times of resin volume of flow velocity during absorption/hour, the ethanol of reuse 50%～95% with 0.4～2 times of resin volume/hour flow velocity be eluted to terminal point, collect eluent;
D. eluent filters, and 70 ℃ of vacuum concentration to ethanol are removed basically, and the concentrated solution spray drying gets the water-soluble portion extract powder, and the spray drying condition is: Tokyo physics and chemistry Spray Dryer SD1000 spray drying appearance, air velocity 0.65m
3/ min, air pressure 18 * 10Kpa, 110 ℃ of inlet temperatures, 70 ℃ of outlet temperatures, 4 units of mixing speed, 1 unit of flow velocity, Clean after every 1 minute;
E. get gelatin, glycerol, simple syrup, purified water mixing, add methyl hydroxybenzoate and nipagin A, add the titanium dioxide of pulverizing 180 mesh sieves again; Abundant mixing; Stir, the degassing, 60～80 ℃ are incubated 30 minutes; The glue of heat is pounced on the glass plate of cleaning, just can be obtained elasticity film preferably after the cooling;
F. with PEG400 and Macrogol 600 with 2: 1 volume mixture, be heated to 40～80 ℃, add water solublity dried cream powder, 4%PEG6000,1% stabilizing agent, 8% glycerol and 8% tween 80; Add volatile oil again; Fully stir the back and cross colloid mill, the degassing, subsequent use;
G. between two-layer film, add the medicinal liquid of quantitative and even, place in the steel mould and suppress, promptly get soft capsule;
Through check, the extraction total recovery of prepared total extract is 2%～2.5%, and the mass ratio of water solublity extract powder and volatile oil is 1～2: 1 in the total extract.
2. method for preparing according to claim 1 is characterized in that: described stabilizing agent is a kind of in fatsoluble vitamin class, the water-soluble vitamins.
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| CN1813833B true CN1813833B (en) | 2012-02-22 |
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| CN101239087B (en) * | 2007-02-05 | 2010-12-01 | 天津药物研究院 | Active component for treating cardio-cerebrovascular disease and oral preparation thereof |
| CN103083458A (en) * | 2013-01-21 | 2013-05-08 | 康美药业股份有限公司 | Warm light drink compound formula granule, as well as preparation method as well as detection method thereof |
| CN105878468A (en) * | 2016-05-31 | 2016-08-24 | 罗翼 | Traditional Chinese medicine for treating blood stasis blocking type amenorrhea |
| CN109350632A (en) * | 2018-12-07 | 2019-02-19 | 四川省中医药科学院 | A kind of Chinese medicine composition for antipyretic-antalgic |
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| CN1660278A (en) * | 2004-12-14 | 2005-08-31 | 沈阳药科大学 | Compound injection of Chinese angelica root and chuanxiong rhizome and preparation method |
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