CN1806757A - Three-dimensional imaging and intellectual treatment system for dermalvascular pathological change - Google Patents
Three-dimensional imaging and intellectual treatment system for dermalvascular pathological change Download PDFInfo
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- CN1806757A CN1806757A CN 200510111514 CN200510111514A CN1806757A CN 1806757 A CN1806757 A CN 1806757A CN 200510111514 CN200510111514 CN 200510111514 CN 200510111514 A CN200510111514 A CN 200510111514A CN 1806757 A CN1806757 A CN 1806757A
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Abstract
A three-dimensional imaging of skin angiopathy and intelligent treatment system, belonging to technology field of medical equipment, comprising: optical fiber used to inject laser into skin tissue, optical fiber used to convey laser reflected or refracted by skin to optical flame detector, near infrared ray optical flame detector / charge-coupled device, Doppler / coherent signal processing system, computer real-time detection and control system working station, laser parameter controller and laser device. The laser device is infrared laser of 805 nm. The invention employs the selective absorption of infrared laser by indocyanine green, which biological tissue adsorbs little and realizes the selective damage to blood vessel. The wavelength of laser of 805-810 nm is much longer than that of currently use, which is 595 nm, so the penetration is deeper which treats deeper blood vessel better, choosing optimum laser parameter automatically by intelligent blood vessel skin damage treating probe, which avoids artificial error, improves treatment effect, reduce purpura and times of repeat treatment.
Description
Technical field
What the present invention relates to is a kind of system of armarium technical field, specifically, relates to a kind of three-dimensional imaging and intellectual treatment system of cutaneous vascular lesion.
Background technology
The vascular dermatosis is one of clinical common disease of beautifying skin.The dermopathic clinical manifestation relevant with vascular lesions has: Fructus Fragariae Ananssae property hemangioma, wine red mottle (I-IV level), psoriasis, skin surface tumor.According to the difference of site of pathological change, the vascular dermatosis can cause breathing, diet, speak or dyskinesia, the most important thing is that the vascular skin lesion can cause the patient to produce serious psychic trauma.Laser therapy vascular skin lesion mainly by the blood vessel at the inaccessible skin lesion of selective light heat effect position, reaches the purpose of treatment vascular skin lesion at present.Treatment doctor to vascular lesions still is in treatment by rule of thumb, the different blood vessel pathological changes is lacked the comparatively objective diagnosis and the judge means of science, especially to the degree of depth of vascular lesion, the thickness of scope and blood vessel, thereby select the parameter (laser energy of laser therapy effectively, action time, the energy density of effect etc.).
Find through literature search prior art, U.S. Patent Publication No. is 6351663, open day is on 02 26th, 2002, and this patent is used the diagnosis that is used for abnormal vasculature of fluorescence staining imaging and the auxiliary laser coagulation of dyeing and the method for treatment condition.Fluorescent dye such as indocyanine green, fluorescein, the application of rosebengal in medical diagnosis and treatment.Use relative high concentration fluorescent dye to strengthen the angiographic definition of fluorescent dye.Use angiography differentiate endovascular blood flow stream to, distinguish that the blood vessel as flowing into damage location in the tumor constitutes, the auxiliary laser coagulation of combination dye reduces the blood flow that flows in the blood vessel that is identified.Its weak point is intellectuality to discern extent of disease, the blood vessel degree of depth, the blood vessel thickness of vascular skin lesion, thereby selects personalized laser therapy parameter, reaches best therapeutic purposes.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of three-dimensional imaging and intellectual treatment system of cutaneous vascular lesion are provided, make it overcome deficiencies such as the treatment repeatedly that causes such as not strong of laser penetration depth as shallow, blood vessel injury selectivity, postoperative purpura, extent of disease, the blood vessel degree of depth, the blood vessel thickness of the intelligent identification of energy vascular skin lesion, thereby select personalized laser therapy parameter, reach better therapeutic effect.
The present invention is achieved by the following technical solutions, the present invention includes: be used for laser inject the optical fiber of skin histology, the optical fiber, near infrared ray sensillum opticum/charge-coupled image sensor, Doppler/coherent signal processor, computer real-time that imports skin histology reflection/refractive laser into sensillum opticum detects control system work station, laser parameter controller, laser instrument.Annexation is: the input of laser that laser instrument sends is used for laser is injected the optical fiber of skin histology, the optical fiber that is used for laser is injected skin histology with the direct guiding function of laser in skin surface.Collect by the optical fiber that skin histology reflection/refractive laser is imported into sensillum opticum by the 1100nm fluorescence that skin histology reflects, the input of optical signal input sensillum opticum/charge-coupled image sensor of collecting, carry out the photoelectricity conversion processing, optical signal is after the record of charge-coupled image sensor and sensillum opticum are converted into the signal of telecommunication, result outputs to Doppler/coherent signal processor and handles, processing calculates the degree of depth and the thickness of blood vessel in this place's skin histology, result is imported the input that computer real-time detects the control system work station, detect the laser parameter (time of selecting to be used for accordingly laser therapy the control system work station according to the blood vessel degree of depth of gained and the situation of thickness from computer real-time, energy density etc.), feedback is input to the input of infrared laser, after laser parameter controller adjusting control, laser instrument sends the laser of relevant parameter, be conveyed into the optical fiber that laser is injected skin histology and treat, constitute the work closed loop of detection-treatment.
The invention has the beneficial effects as follows: utilize indocyanine green that the selectivity of iraser is absorbed, biological tissue to this wavelength absorption seldom reaches the selective injury to blood vessel.805-810nm laser is longer than the 595nm optical maser wavelength of generally using at present, penetration depth is darker, for blood vessel better therapeutic is arranged than deep layer, by intelligentized vascular skin lesion treatment probe, automatically select best laser parameter, avoided the personal error of treatment by rule of thumb, improve therapeutic effect, reduce the postoperative purpura, reduce the number of times of treatment repeatedly.
Description of drawings
Fig. 1 is a structure principle chart of the present invention
The specific embodiment
As shown in Figure 1, the present invention includes: be used for laser inject the optical fiber 1 of skin histology, the optical fiber 2, near infrared ray sensillum opticum/charge-coupled image sensor 3, Doppler/coherent signal processor 4, computer real-time that imports skin histology reflection/refractive laser into sensillum opticum detects control system work station 5, laser parameter controller 6, laser instrument 7.The laser input that laser instrument 7 sends is used for laser is injected the optical fiber 1 of skin histology, the optical fiber 1 that is used for laser is injected skin histology with the direct guiding function of laser in skin surface, collect by the optical fiber 2 that skin histology reflection/refractive laser is imported into sensillum opticum by the fluorescence that skin histology reflects, the input of optical signal input near infrared ray sensillum opticum/charge-coupled image sensor 3 of collecting, carry out the photoelectricity conversion processing, optical signal is after the record of near infrared ray sensillum opticum/charge-coupled image sensor 3 and sensillum opticum are converted into the signal of telecommunication, result outputs to Doppler/coherent signal processor 4 and handles, processing calculates the degree of depth and the thickness of blood vessel in this place's skin histology, result is imported the input that computer real-time detects control system work station 5, detect the laser parameter of selecting to be used for accordingly laser therapy the control system work station 5 according to the blood vessel degree of depth of gained and the situation of thickness from computer real-time, feedback is input to laser parameter controller 6, regulating and controlling laser instrument 7 sends the laser of relevant parameter, be conveyed into the optical fiber 1 that is used for laser is injected skin histology and treat, constitute the work closed loop of detection-treatment.
Described laser instrument 7 is infrared laser, for example: 805nm laser instrument particularly.
Described laser is injected the optical fiber 1 of skin histology, and numerical aperture is 0.22,0.4 to 0.6 millimeter of core diameter, long 0.5 meter to 2 meters.
Describedly import skin histology reflection/refractive laser the optical fiber 2 of sensillum opticum into, numerical aperture is 0.22,0.4 to 0.6 millimeter of core diameter, long 0.5 meter to 2 meters.
Work process of the present invention and principle are: earlier with indocyanine green by intravenous injection in patient's arteries, after about 3-5 minute, indocyanine green can arrive parts of body by circulation, the iraser of the low energy densities that will be produced by infrared laser 7 shines diseased region by the optical fiber 1 that is used for laser is injected skin histology earlier, indocyanine green is excited to send the fluorescence of 1100nm wavelength under infrared wavelength, the fluorescence that produces is collected the optical fiber 2 that skin histology reflection/refractive laser imports sensillum opticum into skin histology, use near infrared ray sensillum opticum/charge-coupled image sensor 4 that its fluorescence intensity of bringing out and scope are detected in real time, carry out effective Infrared fluorescence photography, and import signal into Doppler/coherent signal processor 4, import the signal after handling into computer real-time and detect control system work station 5, thereby the scope that vascular lesion distributes is measured, monitored the concentration of indocyanine green simultaneously in real time at diseased region; Utilize doppler principle and coherent interference measuring technique, according to being in the degree of depth that different depth blood vessel emitted fluorescence detects vascularity, and survey the thickness of vascular tissue according in blood vessel, the flow Doppler effect that produces of indocyanine green.According to the blood vessel degree of depth and vascular tissue's thickness, select corresponding laser parameter (laser energy, action time, the energy density of effect etc.) automatically.
When the fluorescence intensity that Doppler/coherent signal processor 4 detects reaches maximum, the indocyanine green concentration that diseased region this moment is described reaches the highest, computer real-time detects control system work station 5 according to the blood vessel degree of depth, the treatment parameter that thickness is selected feeds back to infrared laser 7, shine by the vascular lesion scope that 1 pair of infrared photography of optical fiber of laser being injected skin histology shows, utilize concentrating relatively of vascular lesion position indocyanine green to assemble, with the absorption of indocyanine green to iraser, produce the laser photocoagulation effect, to cause selective injury, reach vascular lesions selective therapy purpose to vascular lesion.
Claims (5)
1, a kind of three-dimensional imaging of cutaneous vascular lesion and intellectual treatment system, comprise: the optical fiber (1) that is used for laser is injected skin histology, skin histology reflection/refractive laser is imported into the optical fiber (2) of sensillum opticum, near infrared ray sensillum opticum/charge-coupled image sensor (3), Doppler/coherent signal processor (4), computer real-time detects control system work station (5), laser parameter controller (6), laser instrument (7), it is characterized in that, the laser input that laser instrument (7) sends is used for laser is injected the optical fiber (1) of skin histology, the optical fiber (1) that is used for laser is injected skin histology with the direct guiding function of laser in skin surface, collect by the optical fiber (2) that skin histology reflection/refractive laser is imported into sensillum opticum by the fluorescence that skin histology reflects, the input of optical signal input near infrared ray sensillum opticum/charge-coupled image sensor (3) of collecting, carry out the photoelectricity conversion processing, optical signal is after the record of near infrared ray sensillum opticum/charge-coupled image sensor (3) and sensillum opticum are converted into the signal of telecommunication, result outputs to Doppler/coherent signal processor (4) and handles, processing calculates the degree of depth and the thickness of blood vessel in this place's skin histology, result is imported the input that computer real-time detects control system work station (5), detect the laser parameter that selection the control system work station (5) is used for laser therapy accordingly according to the situation of the blood vessel degree of depth of gained and thickness from computer real-time, feedback is input to laser parameter controller (6), regulate the laser that control laser instrument (7) sends relevant parameter, be conveyed into the optical fiber (1) that is used for laser is injected skin histology and treat, constitute the work closed loop of detection-treatment.
2, the three-dimensional imaging of cutaneous vascular lesion according to claim 1 and intellectual treatment system is characterized in that, described laser instrument 7 is infrared laser.
According to the three-dimensional imaging and the intellectual treatment system of claim 1 or 2 described cutaneous vascular lesions, it is characterized in that 3, described laser instrument 7 is the 805nm infrared laser.
4, the three-dimensional imaging of cutaneous vascular lesion according to claim 1 and intellectual treatment system is characterized in that, described laser is injected the optical fiber (1) of skin histology, and numerical aperture is 0.22,0.4 to 0.6 millimeter of core diameter, long 0.5 meter to 2 meters.
5, the three-dimensional imaging of cutaneous vascular lesion according to claim 1 and intellectual treatment system, it is characterized in that describedly import skin histology reflection/refractive laser the optical fiber (2) of sensillum opticum into, numerical aperture is 0.22,0.4 to 0.6 millimeter of core diameter, long 0.5 meter to 2 meters.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510111514 CN1806757A (en) | 2005-12-15 | 2005-12-15 | Three-dimensional imaging and intellectual treatment system for dermalvascular pathological change |
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| CN 200510111514 CN1806757A (en) | 2005-12-15 | 2005-12-15 | Three-dimensional imaging and intellectual treatment system for dermalvascular pathological change |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102019043A (en) * | 2010-11-24 | 2011-04-20 | 曲锰 | Skin disease therapeutic instrument |
| CN103169480A (en) * | 2013-03-18 | 2013-06-26 | 中国科学院苏州生物医学工程技术研究所 | Near-infrared three-dimensional dynamic imager system based on single photon counter |
| WO2013143444A1 (en) * | 2012-03-26 | 2013-10-03 | New Chinese Biotechnology Corporation Ltd. | Method and apparatus for obtaining vasodilation data representing cutaneous local thermal hyperemia response of a subject |
| CN103908239A (en) * | 2014-03-06 | 2014-07-09 | 中国科学院苏州生物医学工程技术研究所 | Non-contact imaging system and imaging method thereof |
| CN104688332A (en) * | 2013-12-05 | 2015-06-10 | 韦伯斯特生物官能(以色列)有限公司 | Needle catheter utilizing optical spectroscopy for tumor identification and ablation |
| CN109924969A (en) * | 2019-04-19 | 2019-06-25 | 优谱激光科技(南京)有限公司 | A kind of laser imaging blood perfusion detection device with light probe |
-
2005
- 2005-12-15 CN CN 200510111514 patent/CN1806757A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102019043A (en) * | 2010-11-24 | 2011-04-20 | 曲锰 | Skin disease therapeutic instrument |
| WO2013143444A1 (en) * | 2012-03-26 | 2013-10-03 | New Chinese Biotechnology Corporation Ltd. | Method and apparatus for obtaining vasodilation data representing cutaneous local thermal hyperemia response of a subject |
| AU2013242693B2 (en) * | 2012-03-26 | 2015-08-06 | New Chinese Biotechnology Corporation Ltd. | Method and apparatus for obtaining vasodilation data representing cutaneous local thermal hyperemia response of a subject |
| RU2576505C1 (en) * | 2012-03-26 | 2016-03-10 | Нью Чайниз Биотекнолоджи Корпорейшн Лтд. | Method and apparatus for receiving vasodilation data as individual's local coetaneous thermal hyperemic response |
| TWI561212B (en) * | 2012-03-26 | 2016-12-11 | New Chinese Biotechnology Corp Ltd | Method and apparatus for obtaining vasodilation data representing cutaneous local thermal hyperemia response of a subject |
| CN103169480A (en) * | 2013-03-18 | 2013-06-26 | 中国科学院苏州生物医学工程技术研究所 | Near-infrared three-dimensional dynamic imager system based on single photon counter |
| CN103169480B (en) * | 2013-03-18 | 2014-10-29 | 中国科学院苏州生物医学工程技术研究所 | Near-infrared three-dimensional dynamic imager system based on single photon counter |
| CN104688332A (en) * | 2013-12-05 | 2015-06-10 | 韦伯斯特生物官能(以色列)有限公司 | Needle catheter utilizing optical spectroscopy for tumor identification and ablation |
| CN103908239A (en) * | 2014-03-06 | 2014-07-09 | 中国科学院苏州生物医学工程技术研究所 | Non-contact imaging system and imaging method thereof |
| CN109924969A (en) * | 2019-04-19 | 2019-06-25 | 优谱激光科技(南京)有限公司 | A kind of laser imaging blood perfusion detection device with light probe |
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