CN1799378A - Human colostrum-simulated biological milk powder - Google Patents
Human colostrum-simulated biological milk powder Download PDFInfo
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- CN1799378A CN1799378A CN 200610042145 CN200610042145A CN1799378A CN 1799378 A CN1799378 A CN 1799378A CN 200610042145 CN200610042145 CN 200610042145 CN 200610042145 A CN200610042145 A CN 200610042145A CN 1799378 A CN1799378 A CN 1799378A
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Abstract
The invention provides a biological factor cow's milk powder similar to foremilk, which comprises (by weight ratio) the following raw materials: milk powder 100-250g, immune globulin composition 0.1-120mg, protein biological factor composition 0.2-100mg, biological growth factor composition 0.2-100mg, active bifidobacteria proliferation factor composition 50-300mg, nourishment reinforcement material composition 10-250mg, and oxidation-resisting composition 100ug-100mg.
Description
One, technical field
The present invention prescription provides a kind of milk powder that makes cow's milk " people's emulsification just " and " people's emulsification ", just make a kind of based on immune globulin-G, the biological function factor is milk powder substantive characteristics, that approach " people's colostrum " and " people's emulsification ".
Two, technical background
The essential distinction of human milk and cow's milk is: human milk, particularly divide one week of puerperium to contain the various immunologic function factors and the various growth factor of enrichment with interior people's colostrum.The immunoglobulin (Ig) that wherein contains high concentration, especially globulin-G content is the abundantest, is people's most important antibody in Ruzhong just, accounts for the 75-80% of immunoglobulin (Ig) total amount.Experimental result confirms that every 100ml cow's milk contains globulin-G 13ug, and human milk contains 40000ug.
Industrial applications globulin-G, mainly separation and Extraction from egg is white.Absorbingly be, surprising similar of the composition of the bioactivator in the egg and breast milk, wherein immunoglobulin (Ig) is all being brought into play the infection that strengthens immunologic function, opposing bacterium and virus in vivo, safeguards the important function that the body normal growth is grown.Experimental result confirms; oral immune globulin can obtain the passive immunity protection equally; thereby help body to increase the disease resistance ability, therefore can be used as the immunocompetent functional food factor that has of infant, the elderly and all pursuit healthy populations fully.
Add globulin-G in cow's milk, the meaning of science is exactly: globulin-G is the essential antibacterial protein of infants growth and development.It is necessary adding globulin-G in the baby food of artificial feeding or food breast milk deficiency: because globulin-G is a kind of nospecific immunity factor in the human body, special role is arranged to killing the corrupt coccus of enteron aisle, and effective to gram-positive bacteria.Globulin-G can directly or indirectly promote baby intestinal bacterium bifidobacterium propagation in infants; Can promote that MC forms fine curdled milk in baby's stomach and intestine, help the baby and digest and assimilate; It can promote artificially feeding infant enteric bacteria group's normalization; It can be strengthened the epidemic prevention factor in properdin (properdin), the r-globulin bodies such as (r-glodulin) to increase the resistance to infecting.To the preemie, anti-losing weight arranged especially, the prevention chylopoietic disease promotes effects such as body weight.
The present invention fills a prescription with reference to peak period people colostrum is contained in one week of branch puerperium all kinds of globulin biotic factors and growth factor level based on globulin-G.
Up to the present, the baby milk powder of international most advanced level, and domestic baby formula milk powder, its trophic function part progressively is on close level to human milk.On this basis, the present invention's prescription has solved the new problem of biological antibody emphatically, makes this milk powder embody the meaning of people's emulsification just in itself.
Three, summary of the invention
1, the important feature of the present invention's prescription is: based on the globulin biotic factor composition of globulin-G.
In globulin, based on globulin-G,, combine other all kinds of globulin and cytokine and peptide etc. is reconciled in immunity, thereby formed high concentration, abundant biological antibody according to the kind and the peak level of people's colostrum.
2. the important feature of the present invention's prescription is: based on the biotic factor composition of insulin-like growth factor.
The people is just contained a large amount of various growth factors in the Ruzhong.The present invention prescription combines insulin-like growth factor, TGF, EGF, fibroblast growth factor according to the kind and the contents level of people's colostrum, and prolactin(PRL, gonadotropin-releasing hormone (GRH).
3. the important feature of the present invention's prescription is: without the bifidobacterium longum and the bifid MF sugar biotic factor composition of genetic modification.
People's colostrum has absorbing of very strong conciliation gastrointestinal bacterial flora, enriched nutritive material and promotes the effect that infant, adolescent growth are grown.The present invention prescription will add globulin-G to strengthening the effect of bifidobacterium growth ability without the bifidobacterium longum and the combination of bifid MF sugar of genetic modification, make Bifidobacterium content in the milk powder reach the level of people's colostrum.
4. the important feature of the present invention's prescription is: the oxidation-resistant material composition in person in middle and old age's milk powder.
Response to oxidative stress will regularly take place in people in middle age, and influence the normal flow direction of many physiology courses, thereby cause aging and various diseases.This prescription has made up beta carotene, natural amber acid fat (VE) and ascorbic acid (VC) anti-oxidant " iron triangle " in right amount, has the obvious effect of removing interior free yl.
5. the important feature of the present invention's prescription is: the fortification material compositions in person in middle and old age's milk powder.
Fortification material compositions in the present invention's prescription has been used in combination whey powder, 1, and 6-diphosphofructose, glutamine peptide, creatine monohydrate, five kinds of fortification materials of L-carnitine are particularly suitable for the elderly.
The physiological function of this composition is: (1) improves immunoloregulation function; (2) the essential amino acid supply source is safeguarded myogen, resists infection; (3) keep the enteron aisle normal function, improve the human body immunocompetence, improve acid-base balance in the body, improve the human body adaptive capacity; (4) improve the energetic supersession of cardiac muscle cell under the anoxia condition, avoid the tissue damage under anoxic and ischemic condition, the decreased renal function that improvement is caused during by heart failure to acute myocardial infarction, cardiac insufficiency, coronary heart disease, myocardial ischemia, can be used as supplement.Can promote protein synthetic of liver cell DNA; (5) antifatigue; (6) defatting beauty effect; (7) regulate blood fat.
Four, embodiment
Human colostrum-simulated biological milk powder of the present invention, comprise compositions such as immune globulin composite, protein biology factor composition, Biological somatomedin composition, the active bacterium of bifidobacterium longum, Bifidobacterium MF composition, fortification material compositions and oxidation-resistant material composition, the weight proportion of each composition is:
Milk powder 100-250g, immune globulin composite 0.1-120mg, protein biology factor composition 0.2-100mg, Biological somatomedin composition 0.2-100mg, the active bacterium 6 * 10 of bifidobacterium longum
6-15 * 10
6(individual), Bifidobacterium MF composition 50-300mg, fortification material compositions 10-250mg, oxidation-resistant material 100ug-100mg
The weight proportion of each composition can for:
Milk powder 100g, immune globulin composite 10mg, protein biology factor composition 30mg, Biological somatomedin composition 30mg, the active bacterium 6 * 10 of bifidobacterium longum
6(individual), Bifidobacterium MF composition 50mg, fortification material compositions 100mg, oxidation-resistant material composition 5mg.
The weight proportion of each composition can also for:
Milk powder 150g, immune globulin composite 20mg, protein biology factor composition 46mg, Biological somatomedin composition 20mg, the active bacterium 10 * 10 of bifidobacterium longum
6(individual), Bifidobacterium MF composition 100mg, fortification material compositions 150mg, oxidation-resistant material composition 10mg.
Preparation process is as follows:
(1) in proportion that ball immune globulin composite, protein biology factor composition, Biological somatomedin composition, the active bacterium of bifidobacterium longum and Bifidobacterium MF composition is water-soluble, mix, to make freeze-dried powder standby for the vacuum freezing drying under 0-10 ℃ temperature;
(2) in proportion freeze-dried powder, fortification material compositions and the solubilization of oxidation-resistant material composition are mixed in milk powder, packing is finished product.
The employed raw material of human colostrum-simulated biological milk powder of the present invention, immune globulin composite are IgG, IgM, IgA, IgD, IgE and SIgA one or more compositions wherein.
The employed raw material of human colostrum-simulated biological milk powder of the present invention, protein biology factor composition are beta lactoglobulin, alpha-lactalbumin, albumin, prealbumin, alpha-1 antitrypsin, a
1-fetoprotein, a
1-macroglobulin, blood clotting lactic acid, hoptoglobin, β
2-microglobulin c
3Complement, α
1-acidoglycoprotein, interleukin 1, interleukin-6, interleukin 10, little gamma interferon, TNF (TNF) and proline polypeptide one or more composition wherein.
The employed raw material of human colostrum-simulated biological milk powder of the present invention, Biological somatomedin composition are insulin-like growth factor I, insulin-like growth factor II, transforming growth factor, transforming growth factor, EGF, fibroblast growth factor, prolactin(PRL and gonadotropin-releasing hormone (GRH) one or more compositions wherein.
The employed raw material of human colostrum-simulated biological milk powder of the present invention, fortification material compositions are lactalbumin, glutamine peptide, creatine monohydrate, L-carnitine, 1,6-diphosphofructose one or more composition wherein.
The employed raw material of human colostrum-simulated biological milk powder of the present invention, oxidation-resistant material composition are beta carotene, natural amber acid fat (VE), ascorbic acid (VC) one or more compositions wherein.
Five, embodiment one
Prescription
(1) milk powder 100g
(2) immune globulin composite: IgG40mg, IgM4.86mg, IgA8.1mg, IgD1mg, IgE0.1mg, SIgA0.1mg.IgG40mg (being equivalent to: 20000u/mg, meter 800000u international unit) wherein
(3) protein biology factor composition:
1. beta lactoglobulin 0.2mg, alpha-lactalbumin 1mg, albumin 8mg, prealbumin 5mg, alpha-1 antitrypsin 2mg;
2. a
1-fetoprotein 3mg, a
1-macroglobulin 0.5mg, blood clotting lactic acid 0.8mg, hoptoglobin 0.25mg;
3. β
2-microglobulin 2mg, c
3Complement 5mg, α
1-acidoglycoprotein 6mg;
4. interleukin 1 0.5mg, interleukin-6 0.5mg, the little gamma interferon 0.5mg of interleukin 10 0.25mg TNF (TNF) 0.6mg;
5. peptide (proline polypeptide) 10mg is reconciled in immunity.
(4) growth factor combination:
1. insulin-like growth factor I (IGF-I) 10mg, insulin-like growth factor II (IGF-II) 7.5mg;
2. transforming growth factor (TGF-α) 5mg, transforming growth factor (TGF-β) 3.5mg;
3. EGF (EGF) 2mg;
4. fibroblast growth factor (FCF) 2.5mg;
5. prolactin(PRL 3.5mg, gonadotropin-releasing hormone (GRH) 0.2mg.
(5) the active bacterium 6 * 106 of bifidobacterium longum
(6) Bifidobacterium MF composition: lactitol (Oilgosaccharkdes) 150mg, stachyose (strong Oilgosaccharkdes) 50mg.
(7) fortification material compositions:
1. lactalbumin 100mg
2. glutamine peptide 10mg
3. creatine monohydrate 15mg
4. L-carnitine 15mg
5. 1,6-diphosphofructose 25mg
(8) oxidation-resistant material composition
Beta carotene 100ug, natural amber acid fat (VE) 15mg, ascorbic acid (VC) 20mg.
Preparation process:
(1) in proportion active bacterium of ball immune globulin composite, protein biology factor composition, Biological somatomedin composition, bifidobacterium longum and Bifidobacterium MF composition are mixed, to make freeze-dried powder standby for the vacuum freezing drying under 0-10 ℃ temperature;
(2) in proportion freeze-dried powder, fortification material compositions and the solubilization of oxidation-resistant material composition are stirred in milk powder, packing is finished product.
Embodiment two
Prescription
(1) milk powder 150g
(2) immune globulin composite
IgG35mg、IgM6mg、IgA10mg、IgD1mg、IgE0.2mg、SIgA0.2mg。
(3) protein biology factor composition
1. beta lactoglobulin 0.3mg, alpha-lactalbumin 2mg, albumin 10mg, prealbumin 8mg, alpha-1 antitrypsin 3mg;
2. a
1-fetoprotein 3mg, a
1-macroglobulin 0.6mg, blood clotting lactic acid 0.9mg, hoptoglobin 0.3mg
3. β
2-microglobulin 3mg, c
3Complement 5mg, α
1-acidoglycoprotein 8mg;
4. interleukin 10 .6mg, interleukin-6 0.6mg, the little gamma interferon 0.6mg of interleukin 10 0.25mg TNF (TNF) 0.6mg;
5. peptide (proline polypeptide) 8mg is reconciled in immunity.
(4) growth factor combination
1. insulin-like growth factor I (IGF-I) 15mg, insulin-like growth factor II (IGF-II) 10mg;
2. transforming growth factor (TGF-α) 6mg, transforming growth factor (TGF-β) 3.5mg;
3. EGF (EGF) 3mg;
4. fibroblast growth factor (FCF) 3mg;
5. prolactin(PRL 3.5mg, gonadotropin-releasing hormone (GRH) 0.5mg.
(5) the active bacterium 7 * 10 of bifidobacterium longum
6
(6) Bifidobacterium MF
Lactitol (Oilgosaccharkdes) 200mg, stachyose (strong Oilgosaccharkdes) 50mg.
(7) fortification material compositions
1. lactalbumin 120mg
2. glutamine peptide 20mg
3. creatine monohydrate 20mg
4. L-carnitine 15mg
5. 1,6-diphosphofructose 35mg
(8) oxidation-resistant material composition 35+100ug
Beta carotene 120ug, natural amber acid fat (VE) 18mg, ascorbic acid (VC) 22mg.
The preparation method is identical with embodiment one.
Claims (6)
1, human colostrum-simulated biological milk powder, it is characterized in that comprising immune globulin composite, protein biology factor composition, Biological somatomedin composition, the active bacterium of bifidobacterium longum, Bifidobacterium MF composition, fortification material compositions and oxidation-resistant material composition, the weight proportion of each composition is:
Milk powder 100-250g, immune globulin composite 0.1-120mg, protein biology factor composition 0.2-100mg, Biological somatomedin composition 0.2-100mg, the active bacterium 6 * 10 of bifidobacterium longum
6-15 * 10
6(individual), Bifidobacterium MF composition 50-300mg, fortification material compositions 10-250mg, oxidation-resistant material composition 100ug-100mg, preparation process is as follows:
(1) in proportion that immunoglobulin (Ig), protein biology factor composition, Biological somatomedin composition, the active bacterium of bifidobacterium longum and Bifidobacterium MF composition is water-soluble, mix, to make freeze-dried powder standby for the vacuum freezing drying under 0-10 ℃ temperature;
(2) freeze-dried powder, fortification material compositions and oxidation-resistant material composition are added in the milk powder mix in proportion, packing is finished product.
According to claims 1 described human colostrum-simulated biological milk powder, it is characterized in that 2, immune globulin composite is IgG, IgM, IgA, IgD, IgE and SIgA one or more a composition wherein.
According to claims 1 described human colostrum-simulated biological milk powder, it is characterized in that 3, the protein biology factor composition is beta lactoglobulin, alpha-lactalbumin, albumin, prealbumin, alpha-1 antitrypsin, a
1-fetoprotein, a
1-macroglobulin, blood clotting lactic acid, hoptoglobin, β
2-microglobulin c
3Complement, α
1-acidoglycoprotein, interleukin 1, interleukin-6, interleukin 10, little gamma interferon, TNF (TNF) and proline polypeptide one or more composition wherein.
4,, it is characterized in that the Biological somatomedin composition is insulin-like growth factor I, insulin-like growth factor II, transforming growth factor, transforming growth factor, EGF, fibroblast growth factor, prolactin(PRL and gonadotropin-releasing hormone (GRH) one or more a composition wherein according to claims 1 described human colostrum-simulated biological milk powder.
5,, it is characterized in that the fortification material compositions is lactalbumin, glutamine peptide, creatine monohydrate, L-carnitine, 1,6-diphosphofructose one or more composition wherein according to claims 1 described human colostrum-simulated biological milk powder.
According to claims 1 described human colostrum-simulated biological milk powder, it is characterized in that 6, the oxidation-resistant material composition is beta carotene, natural amber acid fat (VE), ascorbic acid (VC) one or more a composition wherein.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100421453A CN100486444C (en) | 2006-01-11 | 2006-01-11 | Human colostrum-simulated biological milk powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100421453A CN100486444C (en) | 2006-01-11 | 2006-01-11 | Human colostrum-simulated biological milk powder |
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| Publication Number | Publication Date |
|---|---|
| CN1799378A true CN1799378A (en) | 2006-07-12 |
| CN100486444C CN100486444C (en) | 2009-05-13 |
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ID=36809761
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100421453A Active CN100486444C (en) | 2006-01-11 | 2006-01-11 | Human colostrum-simulated biological milk powder |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101219152B (en) * | 2008-02-01 | 2010-08-04 | 吉林农业大学 | Immune bovine colostrum and method for preparing bifidobacteria composite tiny capsule and pill |
| CN101953403A (en) * | 2010-09-25 | 2011-01-26 | 澳优乳业（中国）有限公司 | Infant formula milk powder added with secretory immunoglobulin A and preparation method thereof |
| CN102578590A (en) * | 2011-01-06 | 2012-07-18 | 中国人民解放军第二军医大学 | Application of alphal-acid glycoprotein |
| CN101530129B (en) * | 2008-03-13 | 2012-08-22 | 张保钢 | Production method of freeze-dried milk powder |
| CN107372834A (en) * | 2017-08-16 | 2017-11-24 | 东北农业大学 | A kind of babies ' formula milk powder for adding cow colostrum active growth factor |
-
2006
- 2006-01-11 CN CNB2006100421453A patent/CN100486444C/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101219152B (en) * | 2008-02-01 | 2010-08-04 | 吉林农业大学 | Immune bovine colostrum and method for preparing bifidobacteria composite tiny capsule and pill |
| CN101530129B (en) * | 2008-03-13 | 2012-08-22 | 张保钢 | Production method of freeze-dried milk powder |
| CN101953403A (en) * | 2010-09-25 | 2011-01-26 | 澳优乳业（中国）有限公司 | Infant formula milk powder added with secretory immunoglobulin A and preparation method thereof |
| CN101953403B (en) * | 2010-09-25 | 2012-05-23 | 澳优乳业（中国）有限公司 | Infant formula milk powder added with secretory immunoglobulin A and preparation method thereof |
| CN102578590A (en) * | 2011-01-06 | 2012-07-18 | 中国人民解放军第二军医大学 | Application of alphal-acid glycoprotein |
| CN107372834A (en) * | 2017-08-16 | 2017-11-24 | 东北农业大学 | A kind of babies ' formula milk powder for adding cow colostrum active growth factor |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100486444C (en) | 2009-05-13 |
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