CN1796543A - Device for micro cutting tissue of biological cells - Google Patents
Device for micro cutting tissue of biological cells Download PDFInfo
- Publication number
- CN1796543A CN1796543A CN 200410103505 CN200410103505A CN1796543A CN 1796543 A CN1796543 A CN 1796543A CN 200410103505 CN200410103505 CN 200410103505 CN 200410103505 A CN200410103505 A CN 200410103505A CN 1796543 A CN1796543 A CN 1796543A
- Authority
- CN
- China
- Prior art keywords
- tissue
- fine needle
- biological cells
- cutting
- vibration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000005520 cutting process Methods 0.000 title claims abstract description 118
- 230000033001 locomotion Effects 0.000 claims description 30
- 238000006073 displacement reaction Methods 0.000 claims description 22
- 230000003287 optical effect Effects 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 5
- 229910000831 Steel Inorganic materials 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 239000010959 steel Substances 0.000 claims description 4
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 4
- 229910052721 tungsten Inorganic materials 0.000 claims description 4
- 239000010937 tungsten Substances 0.000 claims description 4
- 238000002604 ultrasonography Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 description 17
- 238000010586 diagram Methods 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000001467 acupuncture Methods 0.000 description 2
- 238000000370 laser capture micro-dissection Methods 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- -1 desoxyribose nucleic acid Chemical class 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 238000001001 laser micro-dissection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
Images
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
This invention describes a biological cell tissue micro-cutting device, comprising a flat and a vibrational cutting section. A slide containing the biological cell tissue can be placed on the flat, which can shift within a space. The vibrational micro-cutting device comprises a needle and a vibrational body. The needle is connected with the vibrational body, which can provide the energy needed for the vibration of the needle, so that the needle can cut the biological cell tissue. The biological cell tissue can move with the triaxial shift of the flat, so that the vibrational cutting section can cut the biological cell tissue at any position.
Description
Technical field
The present invention is meant a kind of utilization can be carried out three-axis moving and can detect the cutting position degree of depth in the space a kind of device for micro cutting tissue of biological cells especially relevant for a kind of device for micro cutting tissue of biological cells.
Background technology
Along with molecular biotechnology makes rapid progress and this technology is applied to human diseases research frequency grows with each passing day, make now bio-science circle be in the beginning of accurate biologic medical revolution.For example in the middle of the field of tumor research, come tumor tissues cut into slices with the angle of molecular biosciences medical science and just play the part of case when important part to analyze the Yeast Nucleic Acid (RNA) in the tissue or the research of DNA (desoxyribose nucleic acid) (DNA).This is that the biochemistry and the characteristic of physics by complexity mixes and form because general cell tissue is generally various kinds of cell, and doubtful morbidity block is also non-is made of the problem cell fully.
In addition, the performance of the gene of more study a question cell or specific cell tissue, optimal is the homogenous cell group.Yet acquisition homogenous cell group's step also is not easy, through regular meeting's mixing and interferometric analysis result's exactness because of contiguous other group cell.So being necessary property of technical research and urgency how effectively to differentiate and obtain incidence tissue's block.
In recent years since the little cutting technique of Laser Microbeam as, micro laser is caught cutting (LaserCapture Micro-dissection, LCM), micro laser cutting (Laser Micro-Dissection, LMD) and laser pressure capture device (Laser Pressure Catapulting, LPC) etc. developed can provide fast, highly selective cuts with little cutting of low mixing property, so, still be the main flow of the little cutting design of cell tissue so far by the method that laser technology is carried out the little cutting of cell tissue.Yet above-mentioned three kinds of little cutting methods of cell tissue are perhaps good with regard to the angle effect of " cutting ", but more unfortunate and unavoidable shortcoming is exactly this three big problem that " radiation pollution of sample ", " too expensive " and function only limit to cut.Also promptly, by tissue biopsy's method, differentiate have problem or doubtful cancerization cell tissue to be tested, then develop the cell tissue acquisition diced system of the minimum adverse side effect of a tool, low price, just there is suitable necessity as desire.In view of this,, need a kind of device for micro cutting tissue of biological cells badly, come realistic demand in order to address the above problem.
Summary of the invention
Technical problem to be solved by this invention provides a kind of device for micro cutting tissue of biological cells, and utilization can be carried out the platform and the vibration cutting part of displacement movement in the space, reach the purpose that the may command tissue of biological cells moves to position arbitrarily and cutting.
Secondary objective of the present invention provides a kind of device for micro cutting tissue of biological cells, and utilization can be selected longitudinal vibration and can select the fine needle of transverse vibration to reach the purpose that can cut and organize.
Another object of the present invention provides a kind of device for micro cutting tissue of biological cells, utilizes a rang sensor that is arranged on the fine needle, reaches the purpose that can detect the fine needle cutting position.
To achieve these goals, the invention provides a kind of device for micro cutting tissue of biological cells, it includes: a platform and a vibration cutting part.This platform, it can provide puts the microscope slide with a biological cell tissue, and this platform can carry out the displacement movement of diaxon at least in a space.This vibrates cutting part, it can carry out one displacement movement in the space, this vibration cutting part also includes a fine needle and a vibrating mass, this fine needle is connected with this vibrating mass, this vibrating mass can provide this fine needle to vibrate required energy, makes this fine needle carry out cutting action to this tissue of biological cells.Wherein by carrying out this platform and this vibration cutting part that can carry out a motion of the displacement movement of diaxon at least, in the space, form the three-D displacement motion, this tissue of biological cells is moved, this vibration cutting part is cut this tissue of biological cells in arbitrary position.
In order to achieve the above object, the present invention also provides a kind of device for micro cutting tissue of biological cells, and it includes: a platform and a vibration cutting part.This platform, it can provide puts the microscope slide with a biological cell tissue, and this platform can carry out three displacement movement in a space.This vibrates cutting part, and it also includes a fine needle and a vibrating mass, and this fine needle is connected with this vibrating mass, and this vibrating mass can provide this fine needle to vibrate required energy, makes this fine needle carry out cutting action to this tissue of biological cells.Wherein this platform can make this tissue of biological cells move by three displacement movement, and this vibration cutting part is cut this tissue of biological cells in arbitrary position.
In order to achieve the above object, the present invention also provides a kind of device for micro cutting tissue of biological cells, and it includes: a platform and a vibration cutting part.This platform, it is can provide to put the microscope slide with a biological cell tissue, this platform can carry out at least one displacement movement in a space.This vibrates cutting part, it can carry out two displacement movement in the space, this vibration cutting part also includes a fine needle and a vibrating mass, this fine needle is connected with this vibrating mass, this vibration system can provide this fine needle to vibrate required energy, makes this fine needle carry out cutting action to this tissue of biological cells.Wherein by carrying out this platform and this vibration cutting part that can carry out two motions of at least one displacement movement, in the space, form the three-D displacement motion, this tissue of biological cells is moved, this vibration cutting part is cut this tissue of biological cells in arbitrary position.
Describe the present invention below in conjunction with the drawings and specific embodiments, but not as a limitation of the invention.
Description of drawings
Fig. 1 is the first preferred embodiment synoptic diagram of device for micro cutting tissue of biological cells of the present invention;
Fig. 2 is the second preferred embodiment synoptic diagram of device for micro cutting tissue of biological cells of the present invention;
Fig. 3 is the 3rd preferred embodiment synoptic diagram of device for micro cutting tissue of biological cells of the present invention;
Fig. 4 A to Fig. 4 D is other preferred embodiment synoptic diagram of device for micro cutting tissue of biological cells of the present invention.
Wherein, Reference numeral:
The 1-device for micro cutting tissue of biological cells
The 11-platform
12-vibrates cutting part
The 121-fine needle
The 122-vibrating mass
The 13-optical viewing arrangement
The 14-support
The 15-microscope slide
The 16-transmitter
Device for micro cutting tissue of biological cells
The 21-platform
22-vibrates cutting part
The 121-fine needle
The 122-vibrating mass
The 23-optical viewing arrangement
The 24-support
The 25-microscope slide
The 26-transmitter
Device for micro cutting tissue of biological cells
The 31-platform
32-vibrates cutting part
The 321-fine needle
The 322-vibrating mass
The 33-optical viewing arrangement
The 34-support
The 35-microscope slide
The 36-transmitter
The 4-tissue of biological cells
81-longitudinal vibration
The 82-transverse vibration
The 91-first degree of freedom displacement movement
The 92-second degree of freedom displacement movement
93-three degree of freedom displacement movement
Embodiment
See also shown in Figure 1ly, this figure is the first preferred embodiment synoptic diagram of device for micro cutting tissue of biological cells of the present invention.This device for micro cutting tissue of biological cells 1 includes a platform 11 and a vibration cutting part 12.This platform 11, it can provide puts the microscope slide 15 with a biological cell tissue 4, and this platform 11 can carry out the displacement movement of diaxon 91,92 in a space.This vibrates cutting part 12, and it can carry out one 93 displacement movement in this space.This vibration cutting part 12 also includes a fine needle 121 and a vibrating mass 122, and this fine needle 121 is connected with this vibrating mass 122, and this fine needle 121 can be by glass material, hard metal for example: steel or tungsten are made.
This vibrating mass 122 can provide this fine needle 121 to carry out the required energy of ultrasound vibration, makes this fine needle produce a transverse vibration 82 to select making this fine needle 121 produce a longitudinal vibration 81 and select, in order to this tissue of biological cells 4 is carried out cutting action.In the present embodiment, this vibrating mass 122 may be selected to be a piezoelectric.This device for micro cutting tissue of biological cells 1 also has a support 14, an optical observation portion 13 and a transmitter 16.This support 14 can provide fixes this vibration cutting part 12, and this optical observation portion 13 can provide this fine needle 121 of observation to cut the state of these tissue of biological cells 4.For the position of accurate this fine needle 121 of control, this transmitter 16, it can provide the position of this fine needle 121 of detecting in cutting process.This transmitter 16 can select vibration transducer and sonic sensor one of them.
See also shown in Figure 2ly, this figure is the second preferred embodiment synoptic diagram of device for micro cutting tissue of biological cells of the present invention.This device for micro cutting tissue of biological cells 2 includes a platform 21 and a vibration cutting part 22.This platform 21, it can provide puts the microscope slide 25 with a biological cell tissue 4, and this platform 21 can carry out three 91,92,93 displacement movement in a space.This vibrates cutting part 22, and it also includes a fine needle 221 and a vibrating mass 222, and this fine needle 221 is connected with this vibrating mass 222, and this fine needle 221 can be by glass material, hard metal for example: steel or tungsten are made.
This vibrating mass 222 can provide this fine needle 221 to carry out the required energy of ultrasound vibration, makes this fine needle produce a transverse vibration 82 to select making this fine needle 221 produce a longitudinal vibration 81 and select, in order to this tissue of biological cells 4 is carried out cutting action.In the present embodiment, this vibrating mass 222 may be selected to be a piezoelectric.This device for micro cutting tissue of biological cells 2 has more a support 24, an optical observation portion 23 and a transmitter 26.This support 24 can provide fixes this vibration cutting part 22, and this optical observation portion 23 can provide this fine needle 221 of observation to cut the state of these tissue of biological cells 4.For the position of accurate this fine needle 221 of control, this transmitter 26, it can provide the position of this fine needle 221 of detecting in cutting process.This transmitter 26 can select vibration transducer and sonic sensor one of them.
See also shown in Figure 3ly, this figure is the 3rd a preferred embodiment synoptic diagram of device for micro cutting tissue of biological cells of the present invention.This device for micro cutting tissue of biological cells 3 includes a platform 31 and a vibration cutting part 32.This platform 31, it can provide puts the microscope slide 35 with a biological cell tissue 4, and this platform 31 can carry out one 91 displacement movement in a space.This vibrates cutting part, and it can carry out the displacement movement of diaxon 92,93 in this space.This vibrates cutting part 32, also includes a fine needle 321 and a vibrating mass 322, and this fine needle 321 is connected with this vibrating mass 322, and this fine needle 321 can be by glass material, hard metal for example: steel or tungsten are made.
This vibrating mass 322 can provide this fine needle 321 to carry out the required energy of ultrasound vibration, makes this fine needle produce a transverse vibration 82 to select making this fine needle 321 produce a longitudinal vibration 81 and select, in order to this tissue of biological cells 4 is carried out cutting action.In the present embodiment, this vibrating mass 322 may be selected to be a piezoelectric.This device for micro cutting tissue of biological cells 3 also has a support 34, an optical observation portion 33 and a transmitter 36.This support 34 can provide fixes this vibration cutting part 32, and this optical observation portion 33 can provide this fine needle 321 of observation to cut the state of these tissue of biological cells 4.For the position of accurate this fine needle 321 of control, this transmitter 36, it can provide the position of this fine needle 321 of detecting in cutting process.This transmitter 36 can select vibration transducer and sonic sensor one of them.
See also shown in Fig. 4 A to Fig. 4 D, this figure is other preferred embodiment synoptic diagram of device for micro cutting tissue of biological cells of the present invention.Follow the spirit of foregoing invention, in order to reach in the space three 91,92,93 motions, under spirit of the present invention, the permutation and combination of platform and vibration cutting part shifting movement is all in the scope of spirit of the present invention.
Next the working method of device of the present invention is described, is the explanation icon with Fig. 1, and the target of the little cutting of tissue of biological cells is finished in the combination of this vibration cutting part 12 and this platform 11.The transverse vibration 82 of this fine needle 121 or longitudinal vibration 81 behaviors can be reached by these vibrating mass 122 prior given strength of force, amplitude and frequencies.And the tip of this fine needle 121 is the surface of planned contact tissue to be cut, and causes and organize block to destroy, and reaches the purpose that tissue cuts.This tissue of biological cells 4 is positioned on this platform 11, control fine needle 121 most advanced and sophisticated optional positions by the two axle movement 91,92 of this platform 11 and one 93 motion of this vibration cutting part 12, reach the effect of this tissue of biological cells 4 of little cutting with these vibrating mass 122 these fine needles 121 of vibration to tissue.
And the method for cutting has two, and wherein first method is for making this fine needle 121 toward vertically vibrating by this vibrating mass 122, and carries out the action of acupuncture cutting along the border in this tissue of biological cells 4 zone to be cut.This kind cutting method, its fine needle vibrational frequency longitudinally need be high more good more, and horizontal vibration is then avoided producing as far as possible.
Its second method is to make this fine needle 121 toward laterally vibrating by this vibrating mass 122.The maximum of this method and aforesaid method does not exist together, for this fine needle 121 is not with linear fashion tissue to be carried out the acupuncture cutting.But zone to be cut in this tissue of biological cells 4 will be by piecemeal the scraping of this fine needle of swaying.As there being a little block of cells that links to each other with tissue in the tissue, compare with aforesaid method, this method cutting fritter tumor tissues can make the fritter tumour separate from tissue quickly.
Organize cutting unit to organize cutting, but then the zone to be cut of expectation is intactly cut with full wafer, and can distinguishes by the observation that is moved to that suction pump or sleeve pipe are incited somebody to action as adopting first method.As adopt second method, then be covered in the liquid organized on the block will with from organizing the isolating fragment of block together to be sucked out, regather for detecting or research is used.Generally, organize block all extremely thin usually, so in most concrete instance, if use first method, then the amplitude size of its this fine needle 121 vibrations only need operate in micrometer range and gets final product.
Because in order to reach the purpose of cutting, the needle point of this fine needle 121 must penetrate as far as possible to this tissue of biological cells 4 inside; Yet deep result just might cause this fine needle to scratch slide 15.Based on this, in organizing cutting process that the cutting position and the degree of depth of this fine needle the best can be provided.The present invention adds a transmitter 16 and solves above-mentioned problem.This transmitter 16 can select vibration transducer and sonic sensor one of them.With the vibration transducer is example, be assemblied in by this vibration transducer and organize on the cutting unit, need when organizing cutting earlier needle point to be inserted in the tissue, until touching this microscope slide 15, and then this fine needle up carried, till this vibration transducer manifests this fine needle 121 and is in empty vibration.Through this preliminary arrangement, the operator just can obtain the position and the degree of depth of an optimum Cutting.Another feasible method is for by installing sonic sensor in the platform near zone of supporting tissue agglomerate, and record fine needle and the situation that microscope slide touches, and suitably adjusts the degree of depth that fine needle penetrates again, can obtain the depth of cut of the best.
Comprehensively above-mentioned, cutting is easy, manufacturing is simple and assemble the characteristics of being easy to owing to having in the present invention, thus can satisfy the demand of industry, and then improve the competitive power of this industry.
Certainly; the present invention also can have other various embodiments; under the situation that does not deviate from spirit of the present invention and essence thereof; those of ordinary skill in the art work as can make various corresponding changes and distortion according to the present invention, but these corresponding changes and distortion all should belong to the protection domain of the appended claim of the present invention.
Claims (11)
1, a kind of device for micro cutting tissue of biological cells is characterized in that, includes:
One platform, it can provide puts the microscope slide with a biological cell tissue, and this platform can carry out three displacement movement in a space; And
One vibration cutting part, it also includes a fine needle and a vibrating mass, and this fine needle is connected with this vibrating mass, and this vibrating mass can a vibrational frequency provide this fine needle to vibrate required energy, makes this fine needle carry out cutting action to this tissue of biological cells.
2, a kind of device for micro cutting tissue of biological cells is characterized in that, includes:
One platform, it can provide to put has one of biological cell tissue microscope slide, and this platform can carry out the displacement movement of diaxon at least in a space; And
One vibration cutting part, it can carry out a motion in the space, this vibration cutting part also includes a fine needle and a vibrating mass, this fine needle is connected with this vibrating mass, this vibrating mass can a vibrational frequency provide this fine needle to vibrate required energy, makes this fine needle carry out cutting action to this tissue of biological cells.
3, a kind of device for micro cutting tissue of biological cells is characterized in that, includes:
One platform, it can provide to put has one of biological cell tissue microscope slide, and this platform can carry out at least one displacement movement in a space; And
One vibration cutting part, it can carry out two axle movement in the space, this vibration cutting part also includes a fine needle and a vibrating mass, this fine needle is connected with this vibrating mass, this vibrating mass can a vibrational frequency provide this fine needle to vibrate required energy, makes this fine needle carry out cutting action to this tissue of biological cells.
As claim 1,2 or 3 described device for micro cutting tissue of biological cells, it is characterized in that 4, this vibrational frequency is the ultrasound frequency.
5, as claim 1,2 or 3 described device for micro cutting tissue of biological cells, it is characterized in that, this vibration can select a longitudinal vibration and a transverse vibration one of them.
6, as claim 1,2 or 3 described device for micro cutting tissue of biological cells, it is characterized in that, this fine needle may be selected to be a tungsten material, steel and a glass material one of them.
As claim 1,2 or 3 described device for micro cutting tissue of biological cells, it is characterized in that 7, this vibrating mass is a piezoelectric element.
8, as claim 1,2 or 3 described device for micro cutting tissue of biological cells, it is characterized in that, also include a transmitter, it can provide the position of this fine needle of detecting in cutting process.
9, device for micro cutting tissue of biological cells as claimed in claim 8 is characterized in that, this transmitter, can select a sonic sensor and a vibration transducer one of them.
10, as claim 1,2 or 3 described device for micro cutting tissue of biological cells, it is characterized in that also having an optical observation portion, provide this fine needle of observation to cut the state of this tissue of biological cells.
As claim 1,2 or 3 described device for micro cutting tissue of biological cells, it is characterized in that 11, this fine needle can be replaced by other biological processing instrument.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410103505 CN1796543A (en) | 2004-12-29 | 2004-12-29 | Device for micro cutting tissue of biological cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410103505 CN1796543A (en) | 2004-12-29 | 2004-12-29 | Device for micro cutting tissue of biological cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1796543A true CN1796543A (en) | 2006-07-05 |
Family
ID=36817863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410103505 Pending CN1796543A (en) | 2004-12-29 | 2004-12-29 | Device for micro cutting tissue of biological cells |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1796543A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101469307B (en) * | 2007-12-28 | 2012-07-04 | 财团法人工业技术研究院 | Cloning apparatus, and segmentation and acquisition mechanism thereof |
| CN103354896A (en) * | 2011-01-21 | 2013-10-16 | 沃拉克有限公司 | Method and device for cutting off one or more sample regions from a sample carrier |
| CN105910560A (en) * | 2016-04-21 | 2016-08-31 | 长春理工大学 | Biological cell ultrasonic atomic force microscopic detection system and method |
-
2004
- 2004-12-29 CN CN 200410103505 patent/CN1796543A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101469307B (en) * | 2007-12-28 | 2012-07-04 | 财团法人工业技术研究院 | Cloning apparatus, and segmentation and acquisition mechanism thereof |
| CN103354896A (en) * | 2011-01-21 | 2013-10-16 | 沃拉克有限公司 | Method and device for cutting off one or more sample regions from a sample carrier |
| CN103354896B (en) * | 2011-01-21 | 2016-04-27 | 沃拉克有限公司 | For excising the method and apparatus of one or more sample area from sample carrier |
| CN105910560A (en) * | 2016-04-21 | 2016-08-31 | 长春理工大学 | Biological cell ultrasonic atomic force microscopic detection system and method |
| CN105910560B (en) * | 2016-04-21 | 2018-06-19 | 长春理工大学 | A kind of biological cell ultrasound atomic force microscopy detecting system and method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6640238B2 (en) | Sampling system | |
| US20230375443A1 (en) | Devices, systems, and methods for extracting a material from a material sample | |
| JP5886908B2 (en) | Acoustic convergence hardware and system and method for implementation | |
| CN1875893A (en) | Microdissection device based on piezoelectric ultrasonic vibration | |
| JP5493006B2 (en) | A device for vibrating a tube containing a biological sample in particular at high speed | |
| JP2010032554A (en) | Method for micro-dissection of tissue | |
| CN101040346A (en) | Device and method for scanning probe microscopy | |
| CN1844908A (en) | Ultrasonic wave detection method and detection apparatus therefor | |
| CN1796543A (en) | Device for micro cutting tissue of biological cells | |
| CN1959404A (en) | Ultrasonic method and device for testing macroscopic cleanness of continuous casting billet | |
| US20200398268A1 (en) | Integrated container adapter for photoacoustic microscopy | |
| Gralinski et al. | Non-contact acoustic trapping in circular cross-section glass capillaries: a numerical study | |
| US11454577B2 (en) | Method and apparatus for collecting biomolecules from specific region of tissue section | |
| Van Damme et al. | The vibration dipole: a time reversed acoustics scheme for the experimental localisation of surface breaking cracks | |
| JP2006329733A (en) | Microsampling apparatus | |
| JP6913184B2 (en) | Biological object processing device | |
| CN1850008A (en) | Piezoelectric supersonic micro-cutting method | |
| WO2011064333A1 (en) | Ultrasonic merging of particles in microwells | |
| CN202485924U (en) | Piezoelectric microdissection system | |
| CN1529158A (en) | Method for realizing enlargement of 3-D supersonic image and supersonic-wave apparatus | |
| CN1445523A (en) | Method for preparing tissue chip | |
| Huang et al. | A novel piezoelectric ultrasonic biological micro-dissection device based on flexure mechanism for suppressing vibration | |
| JP7525657B2 (en) | Cell migration device | |
| CN1431316A (en) | Manipulation method for constracting nano sketch and nano structure | |
| JP2003048193A (en) | Slicing device and slicing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |