CN1788734B - Selenium sulfide nano particle additive preparing method and use - Google Patents
Selenium sulfide nano particle additive preparing method and use Download PDFInfo
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- CN1788734B CN1788734B CN 200410100775 CN200410100775A CN1788734B CN 1788734 B CN1788734 B CN 1788734B CN 200410100775 CN200410100775 CN 200410100775 CN 200410100775 A CN200410100775 A CN 200410100775A CN 1788734 B CN1788734 B CN 1788734B
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- selenium sulfide
- nano particle
- sulfide nano
- particle additive
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Abstract
The present invention discloses the preparation process of nanometer selenium sulfide particle additive including selecting precursor material and controlling reactor temperature and other technological parameters. Further, the prepared nanometer selenium sulfide particle additive is applied in shampoo and other products for treating scurf, seborrheic dermatitis, tinea versicolor, etc. Owing to the characteristic of nanometer particle with great specific surface area, small amount of nanometer selenium sulfide particle additive can result in obvious curative effect.
Description
Technical field
The invention relates to a kind of manufacture method of nanoparticle, be meant a kind of manufacture method and application thereof of selenium sulfide nano particle additive especially.
Background technology
Selenium sulfide is because of having the good bacterium effect of controlling, so the skin care products or the cleaning supplies of known commercially available doping selenium sulfide, be that water-fast selenium sulfide powder suspension is scattered in the basic batching of skin care products or cleaning supplies, with main material as medicine products such as anti-dandruff, treatment seborrhea atopic dermatitis, tinea versicolor or tinea capitis.
Although selenic skin care products of Containing Sulfur or cleaning article for suppress cell division, dissolve cutin, the matter of deoiling with kill oval scurf bud bag bacterium (Malassezia furfur, or claim Pityrosporum ovale again) respond well, but employed now selenium sulfide, its particle diameter is all micron order or bigger particle diameter, very difficult on disperseing, need to add extra suspension dispersive agent batching; Even if can homodisperse, after leaving standstill after a while, still easily precipitation be separated out the selenium sulfide granule.Further, it is contained to be deployed on the pastille cosmetics benchmark of being announced in 93 years 03 month 02 day " other classifications " according to the Taiwan health, when being applied to shampoo, selenium sulfide limits the quantity of in 0.5%, but with regard on the market selenium sulfide size now, shampoo desires to reach effective system bacterium intensity needs content 01-0.5 percentage by weight ability effectively, yet 0.5 percentage by weight has arrived the SC service ceiling of Department of Health's defined.And selenium sulfide has zest to human body hair follicle and mucosa, adds to have sensation of dryness after washing and the residual scruple of color is arranged, and these are not Containing Sulfur selenium product potential collision hazard in the use undoubtedly.
Therefore, the present invention is considering at above-mentioned, proposes a kind of manufacture method and application thereof of selenium sulfide nano particle additive, utilizes nanoparticle to have the characteristic of high surface ratio, effectively reduces the required addition of selenium sulfide, solves the above problems.
Summary of the invention
Main purpose of the present invention is to provide a kind of manufacture method and application thereof of selenium sulfide nano particle additive, it selects, controls the additive that the reactive tank temperature is synthesized the selenium sulfide particle of tool nano-scale by the predecessor raw material, and then makes an addition to the controlling in the bacterium product of personal health widely.
Another object of the present invention is to provide a kind of manufacture method and application thereof of selenium sulfide nano particle additive, the size of the selenium sulfide nano particle in its prepared selenium sulfide nano particle additive is much smaller than 100 nanometers, average diameter is about 5 nanometers, and dispersibility is splendid in additive.
A further object of the present invention is to provide a kind of manufacture method and application thereof of selenium sulfide nano particle additive, its be applied to personal health control the bacterium product time, can under the prerequisite of keeping antibacterial functions, significantly reduce the dosage of the required interpolation of selenium sulfide.
Another purpose of the present invention is to provide a kind of manufacture method and application thereof of selenium sulfide nano particle additive, and it provides the method for a kind of technology synthetic highly concentrated nano selenium sulfide additive simple and with low cost.
Another purpose of the present invention, be to provide a kind of manufacture method and application thereof of selenium sulfide nano particle additive, when it is applied to the antimicrobial product of personal health, therefore can make the transparent color and luster of product, can avoid known patient to smear the puzzlement that affected part behind the Containing Sulfur selenium nano particles additive presents remarkable colour of skin difference.
For achieving the above object, the manufacture method of selenium sulfide nano particle additive provided by the invention, it comprises the following steps:
Be dissolved in the stabilizing agent respectively selenium and sulfur predecessor and stirring, to form two precursor solutions;
Get a wherein precursor solution of appropriate amount, slowly add precursor solution in another concussion with given pace, and continue to stir; And
Carry out molecule reunion reaction, after question response is complete, promptly be prepared into the high concentration selenium sulfide nano particle additive that is scattered in the stabilizing agent.
Described manufacture method, one of group that wherein this selenic predecessor is selected from selenic halogenide, selenic oxide, contains selenic Organic substance, Selenium hydride., selenic acid, selenate radical salt are formed.
Described manufacture method, wherein the predecessor of this sulfur be selected from halogenide, hydroxide sulfur, the sulfur-bearing of sulfur oxide, sulfur Organic substance, hydrogen sulfide, sulfur metallic salt one of them or both are above mixes.
Described manufacture method, wherein this stabilizing agent is selected from above mixing of group one of them or the two that non-ionic interfacial agent, ion-type interfacial agent, cellulose and derived polymers thereof are formed.
Described manufacture method, wherein this mixing speed is 100-1000 rev/min.
Described manufacture method, the temperature of wherein controlling this molecule reunion reaction is 10 ± 5 ℃.
Described manufacture method, the particle diameter of its prepared this selenium sulfide nano particle is less than 100 nanometers.
Described manufacture method, wherein this molecule reunion reaction required time is 1 hour.
Described manufacture method, its prepared this selenium sulfide nano particle additive can directly make an addition in general viscosity or the heavy-gravity solvent.
Described manufacture method, its solvent can be the finished product of reactant in the personal health product technology or personal health product, to obtain the goods of tool antibacterial effect.
The application of the selenium sulfide nano particle additive of the present invention's preparation, it adds the prepared selenium sulfide nano particle additive of said method in the personal health product, has the goods of antibacterial effect with formation.
Description of drawings
Fig. 1 is the flow chart of making selenium sulfide nano particle additive of the present invention.
Fig. 2 is selenium sulfide nano particle transmission electron microscope of the present invention (TEM) photographic view (having the representative photo that actual particle size distributes).
Fig. 3 is selenium sulfide nano particle elementary analysis of the present invention (EDX-TEM) result.
Fig. 4 is the UV, visible light optical absorption spectra of suspension selenium sulfide nano particle aqueous solution of the present invention.
The specific embodiment
For further understanding and understanding more being arranged, do detailed explanation in conjunction with the accompanying drawings with preferred embodiment to architectural feature of the present invention and the effect of being reached:
The invention relates to a kind of manufacture method and application thereof of selenium sulfide bar rice corpuscles additive, the present invention is to adopt to form the selenium sulfide molecule is become nano-scale again by a plurality of molecular aggregatess particle earlier in the method for synthetic selenium sulfide nano particle, just so-called preparation method from lower to upper, this and known micron powder is ground to nano level basipetal mode and inequality.
At first see also Fig. 1, as the predecessor of step S1 with sulfur and selenium composition, under room temperature environment, be dissolved in respectively in the non-ionic stabilizer (interfacial agent), and stir to form two precursor solutions, wherein this selenic predecessor is selected from selenic halogenide, selenic oxide, contain selenic Organic substance, Selenium hydride., selenic acid, one of group that selenate radical salt etc. is formed, and the predecessor of this sulfur is selected from sulfur oxide, the halogenide of sulfur, hydroxide sulfur, the Organic substance of sulfur-bearing, hydrogen sulfide, close the chemical compound of other sulfur such as the metallic salt of sulfur one of them or both above Mians, and this stabilizing agent is selected from non-ionic interfacial agent, the ion-type interfacial agent, the group one of them or the two that cellulose and derived polymers thereof are formed is above to be mixed.
Step S2 for another example, get a wherein precursor solution of appropriate amount, with certain injection rate add slowly another the concussion in precursor solution, at this moment, getting what precursor solution pours in another precursor solution, there is no certain requirement, its emphasis depends on the requirement that the percentage by weight of reaction requirement is prepared, continue as step S3, continue to stir to carry out molecule reunion reaction, the course of reaction time is about one hour, and control reactive tank reaction temperature is greatly between 10 ± 5 ℃, question response back is fully prepared the nano particle additive that is scattered in the selenium sulfide in the stabilizing agent promptly as step S4.
Wherein the speed of this stirring is 100-1000 rev/min (rpm), and the particle diameter of prepared selenium sulfide nano particle is less than 100 nanometers (nm).
See also Fig. 2, the transmission electron microscope photographic view of the nano particle additive of the selenium sulfide of the prepared high weight percent concentration of the present invention, by the particle diameter of the nanoparticle that can learn selenium sulfide of the present invention among the figure less than 100 nanometers, its mean diameter is 5 ± 3 nanometers, and the nano particle additive of this selenium sulfide carried out semiquantitative elementary analysis (EDX:Energy dispersive X-ray), its result as shown in Figure 3, by being about selenium forming of the prepared chemical compound of the present invention as can be known among the figure: sulfur=1: 2, just selenium sulfide (SeS
2).
Further, see also Fig. 4, because when the nano particle additive of the prepared selenium sulfide of the present invention is diluted to the concentration of tool antibacterial effect with water, this aqueous solution has good light peneration for visible light, has strong trap for wavelength less than the light source of 300 nanometers by the nanometer additive that can find the prepared selenium sulfide of the present invention among the figure.
Bacteriostatic test statement number 93CT158-93CT158-2 when the bacteriostatic test gained of the prepared selenium sulfide nano particle additive of the present invention being sneaked into the scurf brood cell bacterium (Malassezia furfur BCRC 22243) that carries out based food industrial development institute in the normal saline solution, its result please read shown in the table 1, can learn when using selenium sulfide nano particle additive content of the present invention to be 0.1 percentage by weight (wt%) by table 1, can suppress the scurf brood cell bacterium immediately, further, even addition of the present invention is reduced to one thousandth, still has quite good effect.
Table 1
| The test group | Bacterium number (CFU/ml) immediately after the mixing | Mix 24 hours bacterium numbers (CFU/ml) |
| Matched group (normal saline) | 6.7×10 5 | 7.3×10 5 |
| Sample sets 1 (selenium sulfide nano particle additive content 0.1wt%) | ＜10 | ＜10 |
| Sample sets 2 (selenium sulfide nano particle additive content 0.01wt%) | 6.0×10 5 | ＜10 |
| The test group | Bacterium number (CFU/ml) immediately after the mixing | Mix 24 hours bacterium numbers (CFU/ml) |
| Sample sets 3 (selenium sulfide nano particle additive content 0.01wt%) | 4.2×10 5 | ＜10 |
Therefore, when the present invention being added into the shampoo and the treatment dandruff, the seborrhea atopic dermatitis, when the individual moral standing of aspects such as tinea versicolor or tinea capitis emulsifiable paste is supported product, the present invention only needs small addition and can reach the selenium sulfide product efficacy of using in the market, can effectively reduce the hair follicle of stimulation human body and the degree of mucosa, and wash back sensation of dryness and the residual shortcoming of color, and the finished product of gained of the present invention is the solution of a liquid state, so when interpolation the present invention is added into the personal health product, only need the present invention is diluted to required weight percent concentration, can be incorporated in the personal health product finished product, perhaps in skin care products technology, be added into suitable facility; And selenium sulfide nano particle additive of the present invention has the good advantage of dispersibility, does not therefore have the known phenomenon that produces Shen Dian because standing time is long and produces.
Further, because selenium sulfide nano particle additive of the present invention has good light peneration, therefore adding the prepared personal health product of the present invention can present good transparency, to present muddy light tight shape greatly different with the personal health product that are added with selenium sulfide that sell on the market for these, so utilize the prepared personal health product of the present invention, for example seborrhea skin moxibustion, tinea versicolor or tinea capitis emulsifiable paste can directly be applied in as face, the affected part that arm etc. manifest, do not smear the puzzlement that presents colour of skin difference behind the affected part and do not have known ointment, meet the double requirements that the modern pursues curative effect and aesthetic feeling.
In sum, the present invention is a kind of selenium sulfide nano particle additive, it utilizes chemical technology mode from bottom to top, synthetic selenium sulfide nano particle with bigger surface area, and when application is of the present invention, can can reach effective antibacterial effect with a spot of addition of the present invention, and then antimicrobial product selenium sulfide content is higher to injury that human body caused on the market of avoiding now.
The above, it only is a preferred embodiment of the present invention, be not to be used for limiting scope of the invention process, so, all should be included in and ask in the claim morning of the present invention such as according to the described shape of the present patent application claim, structure, feature and spiritual impartial for it the variation and modification.
Claims (7)
1. the manufacture method of a selenium sulfide nano particle additive, it comprises the following steps:
Be dissolved in the stabilizing agent respectively selenium and sulfur predecessor and stirring, to form two precursor solutions, wherein this selenium predecessor is selected from one of group that selenic halogenide, selenic oxide, Selenium hydride., selenic acid forms, this sulfur predecessor be selected from sulfur oxide, sulfur halogenide, hydrogen sulfide one of them or both are above mixes, and this stabilizing agent is selected from above mixing of group one of them or the two that non-ionic interfacial agent, ion-type interfacial agent, cellulose are formed;
Get a wherein precursor solution of appropriate amount, add precursor solution in another concussion slowly with given pace, and continue to stir; And
Carry out molecule reunion reaction, the temperature of molecule reunion reaction is 10 ± 5 ℃; After question response is complete, promptly be prepared into the high concentration selenium sulfide nano particle additive that is scattered in the stabilizing agent.
2. the manufacture method of selenium sulfide nano particle additive as claimed in claim 1 is characterized in that, wherein this mixing speed is 100-1000 rev/min.
3. the manufacture method of selenium sulfide nano particle additive as claimed in claim 1 is characterized in that, the particle diameter of its prepared this selenium sulfide nano particle is less than 100 nanometers.
4. the manufacture method of selenium sulfide nano particle additive as claimed in claim 1 is characterized in that, wherein this molecule reunion reaction required time is 1 hour.
5. the manufacture method of selenium sulfide nano particle additive as claimed in claim 1 is characterized in that, its prepared this selenium sulfide nano particle additive can directly make an addition in the solvent.
6. the manufacture method of selenium sulfide nano particle additive as claimed in claim 5 is characterized in that, its solvent is the reactant in the personal health product technology or the finished product of personal health product, to obtain the goods of tool antibacterial effect; Described personal health product are: the emulsifiable paste of shampoo and the treatment dandruff, seborrhea atopic dermatitis, tinea versicolor or tinea capitis.
7. the application of a selenium sulfide nano particle additive, it will add in the personal health product in the prepared selenium sulfide nano particle additive of claim 1, have the goods of antibacterial effect with formation;
Described personal health product are: the emulsifiable paste of shampoo and the treatment dandruff, seborrhea atopic dermatitis, tinea versicolor or tinea capitis.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410100775 CN1788734B (en) | 2004-12-14 | 2004-12-14 | Selenium sulfide nano particle additive preparing method and use |
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| CN 200410100775 CN1788734B (en) | 2004-12-14 | 2004-12-14 | Selenium sulfide nano particle additive preparing method and use |
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| CN1788734A CN1788734A (en) | 2006-06-21 |
| CN1788734B true CN1788734B (en) | 2010-05-05 |
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| CN 200410100775 Expired - Fee Related CN1788734B (en) | 2004-12-14 | 2004-12-14 | Selenium sulfide nano particle additive preparing method and use |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102060277B (en) * | 2010-11-25 | 2013-03-06 | 清远先导材料有限公司 | Production method of selenium sulfide |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1037271A (en) * | 1988-04-28 | 1989-11-22 | 普罗格特-甘布尔公司 | Stable dandruff shampoo Compositions |
| CN1183268A (en) * | 1996-11-15 | 1998-06-03 | 花王株式会社 | Detergent composition |
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2004
- 2004-12-14 CN CN 200410100775 patent/CN1788734B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1037271A (en) * | 1988-04-28 | 1989-11-22 | 普罗格特-甘布尔公司 | Stable dandruff shampoo Compositions |
| CN1183268A (en) * | 1996-11-15 | 1998-06-03 | 花王株式会社 | Detergent composition |
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