CN1785132B - 产生医学图像的方法 - Google Patents
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Abstract
本发明涉及一种用于实施成像检查方法的方法,其中,采用不同的测量参数和/或不同的成像测量方法来测量检查对象的感兴趣区域的至少3个图像数据组。形成第一和第二图像数据组之间的差值图像,并将该差值图像与第三图像数据组叠加。在显示媒体上显示该叠加。
Description
技术领域
本发明涉及一种用于实施成像检查方法以产生医学图像的方法。
背景技术
医生或放射科医师利用成像检查方法可以诊断患者的多种疾病。在此很多疾病需要特殊的检查方法以保证可靠的诊断。尤其是在治疗血管疾病或治疗肿瘤时,成像诊断具有不断增长的意义。在诊断和治疗动脉硬化时例如希望可以量化地采集在患者的血管系统中出现并导致动脉硬化的斑块。例如可以通过规定饮食或采用降低胆固醇的药物来治疗。目前只能监控各个斑块的时间变化。
发明内容
本发明要解决的技术问题是提供一种方法,可以可视化患者的这种疾病。
该技术问题是通过一种用于实施成像检查方法的方法来解决的。其中,首先采用不同的测量参数和/或不同的成像测量方法测量检查对象的感兴趣区域的至少3个图像数据组。接着形成第一和第二图像数据组之间的差值图像。最后将该差值图像与第三图像数据组叠加,并在显示媒体上显示该叠加。在第三图像数据组中例如对感兴趣区域进行完整的成像,而通过修改测量参数或选择最适于用于第一和第二图像数据组的测量方法,可以影响叠加中的显示。这样,可以在最适合的成像条件下突显解释一个医疗问题所需的不同方面。不同成像方法或不同测量参数的成像特征基本上是公知的,从而专业人员可以在提出对应的问题时找到合适的组合。
在本发明的优选实施例中,将磁共振断层造影用作成像检查方法。在此存在很多以图像来显示不同疾病的可能。通过优化测量参数可以特别清楚地突出特定的疾病。
在本方法的特别优选实施例中,采用测量参数或成像测量方法这样来测量第一图像数据组,使得该第一图像数据组能突出地显示出一种疾病。采用测量参数或成像测量方法来这样测量第二图像数据组,使得该第二图像数据组能基本上抑制该疾病的显示。通过形成差值产生差值图像,该差值图像只显示感兴趣区域中的疾病。因此,通过将该差值图像与第三图像数据组叠加显示出感兴趣区域的能清楚的突出该疾病的图像。这为主治医生简化了对疾病的诊断或判断。尤其是可以简单地判断该疾病的规模。通过采用不同的测量方法或测量参数,可以分别为待检查的疾病选择最佳的成像。
为了显示斑块尤其是需要显示脂肪组织。因此在特别有利的方法中,利用脂肪没有饱和的磁共振断层造影测量第一图像数据组,利用脂肪饱和的磁共振断层造影测量第二图像数据组。由于这些图像对于对应的测量除了脂肪成分之外都是一致的,因此在形成差值之后在对应的差值图像中只保留了患者的脂肪组织。通过与第三图像数据组的叠加,可以通过简单的方式判断患者血管系统的斑块负担。
由于患者的脂肪组织通常不会限于血管系统,因此在优选方法中,在叠加前对差值图像进行分割。其中,将未在血管系统中存在的脂肪组织从该图像数据组中除去。为了也能可视化沉积在血管壁中的斑块,将分割的边界大致设置在血管壁的外部,从而血管壁中的斑块完整地保留在图像中。
磁共振断层造影尤其适合于显示患者的血管系统。因此在优选的方法中,第三图像数据组是患者的血管造影或三维血管造影。通过将第三图像数据组限制在血管系统,可以利用与差值图像的叠加特别简单地判断斑块负担。
附图说明
利用下面结合附图描述的实施例解释本发明的其它优点。其中示出了:
图1是优选方法的示意性流程图,
图2是显示出斑块的血管造影的示意图。
具体实施方式
下面的实施例描述了利用磁共振检查量化和显示患者血管系统中的斑块。根据图1,在第一方法步骤S2中测量图像数据组。其中,首先在一次作为血管造影或三维血管造影的磁共振检查中根据公知的方法对血管系统进行成像。第二图像数据组是一张全身照片,在其上面尤其是使脂肪组织可见。作为第三图像数据组,如在第二图像数据组中那样进行相同的拍摄;但这次对脂肪信号进行抑制。其中,可以采用不同的序列,如Turbo自旋回波、HASTE(半傅立叶获取单射Turbo自旋回波)或质子密度序列。为了抑制脂肪信号,利用公知技术通过频率选择的高频脉冲使脂肪质子饱和,从而抑制了对应的磁共振信号。在产生的图像数据组中看不见脂肪组织。
在第二方法步骤S4中形成差值。在此,形成在脂肪饱和与脂肪没有饱和的情况下照片之间的差值。由此从对应的图像数据组中只保留了患者脂肪组织的显示。由于除了斑块之外在患者的身体内一般还存在其它的脂肪组织,因此在第三方法步骤S6中对该差值图像进行分割。由此可以除去未在血管系统中存在的脂肪组织,而在显示中只保留了属于血管系统的斑块。在此,合适的是将分割的边界设置在大致超出血管壁之外,从而还保留了可能存在于血管壁中的斑块。在第四方法步骤S8中,将差值图像与血管造影叠加。这既可以手动地通过医生在监视器上进行,也可以利用公知的图像处理方法自动进行。在第五方法步骤S10中,在显示媒体上显示该叠加的图像,从而医生可以对出现的斑块的数量和分布有个整体印象。
在第六方法步骤S12中,医生可以对识别出的斑块进行详细的检查。其中,可以选择考虑所有斑块或只考虑单个斑块。用计算机鼠标来选择斑块。这些斑块在不同的磁共振测量中受到检查,从而医生获得关于斑块的大小和组成的详细信息。在此,可以实施T1和T2加权的测量,也可以实施质子密度的测量。还可以利用公知的方法确定各个斑块的体积。由各个斑块的体积可以计算出总和。
由测量数据可以使医生量化地判断患者动脉硬化的程度并提出对应的治疗措施。如果例如确定在患者体内存在总体积较大的很多斑块,则指示采用降低胆固醇的药物等。与只能监控单个斑块变化的公知方法相反,这里描述的方法具有的优点是揭示出患者血管系统的总的斑块负担。此外,该方法还适用于对还没有使血管的内腔变窄、但对患者已表现出危险的斑块进行可视化。这种所谓的易攻击斑块例如可能导致中风或心肌梗塞。这些斑块的大部分没有使相应的血管变窄,而是由对应的血管壁中沉积的脂肪组织构成。这种斑块不能用血流测量和X射线透视来诊断。
图2以示意图示出患者血管系统2的血管造影。这是利用磁共振断层造影或计算机断层造影拍摄的。在脂肪饱和与脂肪没有饱和的情况下将血管造影与来自两张全身照片的差值图像叠加。对该差值图像进行分割,从而只显示属于血管系统的脂肪组织。相应的在几个血管的血管壁上可以识别出斑块4来。由此,为诊断医生提供了一幅简单的概貌图像,医生利用该概貌图像可以对动脉硬化的进展有个简单的全面了解。同样也能识别出已存在的易攻击斑块6。
本方法不仅可以显示斑块,还可以在治疗这些斑块的时候采用。这样,可以很好地对这些斑块进行定位以设置导管,并由此简化了治疗。利用所描述的方法可以看见在X射线透视的情况下无法看见的血管壁中的斑块,并由此进行治疗。
本方法的应用不限于利用磁共振断层造影来显示和量化斑块。还可以将不同的测量方法用于拍摄图像数据组。这样,例如可以将磁共振图像与计算机断层造影图像叠加。造影剂的使用为用于显示不同疾病的差值形成提供了用于测量图像数据组的宽频谱。
Claims (8)
1.一种产生医学图像的方法,包括以下步骤:
-采用不同的测量参数和/或不同的成像测量方法来测量检查对象的至少一个感兴趣区域的至少3个图像数据组,
-形成第一和第二图像数据组之间的差值图像,
-将该差值图像与第三图像数据组叠加,
-在显示媒体上显示该叠加,
其中,所述第一和第二图像数据组用磁共振断层造影方法来测量,所述第三图像数据组用计算机断层造影方法来测量。
2.根据权利要求1所述的方法,其中,所述第一和第二图像数据组分别是全身检查。
3.根据权利要求1所述的方法,其中,所述第一图像数据组的测量是在脂肪没有饱和的条件下进行的,所述第二图像数据组的测量是在脂肪饱和的条件下进行的。
4.根据上述权利要求中任一项所述的方法,其中,对所述差值图像进行分割。
5.根据权利要求4所述的方法,其中,所述第三图像数据组是患者的血管造影或三维血管造影。
6.根据权利要求3所述的方法,其中,利用磁共振断层造影和/或计算机断层造影来详细分析各个脂肪沉积。
7.根据权利要求6所述的方法,其中,量化地采集脂肪沉积的体积。
8.根据权利要求7所述的方法,其中,形成所述脂肪沉积的体积的和。
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DE102007056434A1 (de) * | 2007-11-23 | 2009-06-04 | Siemens Ag | Eingabevorrichtung für die Darstellung von medizinischen Bildern auf einem Großdisplay |
DE102008030890A1 (de) * | 2008-06-30 | 2010-01-07 | Siemens Aktiengesellschaft | Verfahren zur Durchführung einer bildgebenden Untersuchungsmethode |
DE102008034313A1 (de) | 2008-07-23 | 2010-02-04 | Siemens Aktiengesellschaft | Verfahren zur Durchführung einer bildgebenden Untersuchungsmethode |
CN102727206B (zh) * | 2011-12-08 | 2014-01-08 | 中国科学院深圳先进技术研究院 | 颅脑、颈动脉和主动脉三位一体的扫描方法及扫描系统 |
US20180192916A1 (en) * | 2017-01-10 | 2018-07-12 | General Electric Company | Imaging system for diagnosing patient condition |
JP2019098167A (ja) * | 2017-11-28 | 2019-06-24 | キヤノン株式会社 | 情報処理装置、情報処理システム、情報処理方法およびプログラム |
CN114176616A (zh) * | 2021-11-30 | 2022-03-15 | 上海联影智能医疗科技有限公司 | 静脉血栓的检测方法、电子设备和存储介质 |
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Patent Citations (5)
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US6377835B1 (en) * | 2000-08-30 | 2002-04-23 | Siemens Aktiengesellschaft | Method for separating arteries and veins in 3D MR angiographic images using correlation analysis |
US20040056660A1 (en) * | 2000-12-28 | 2004-03-25 | Yumiko Yatsui | Magnetic resonance imaging device and method |
US20040002934A1 (en) * | 2002-06-26 | 2004-01-01 | Bradley Taulbee | System and method for providing requested file mapping information for a file on a storage device |
US20040047497A1 (en) * | 2002-09-10 | 2004-03-11 | Confirma, Inc. | User interface for viewing medical images |
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DE102004059133A1 (de) | 2006-07-27 |
US20060173279A1 (en) | 2006-08-03 |
CN1785132A (zh) | 2006-06-14 |
DE102004059133B4 (de) | 2010-07-29 |
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