CN1775067A - Method for producing coated granule phytase - Google Patents
Method for producing coated granule phytase Download PDFInfo
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- CN1775067A CN1775067A CNA2005100199035A CN200510019903A CN1775067A CN 1775067 A CN1775067 A CN 1775067A CN A2005100199035 A CNA2005100199035 A CN A2005100199035A CN 200510019903 A CN200510019903 A CN 200510019903A CN 1775067 A CN1775067 A CN 1775067A
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- phytase
- coated granule
- production method
- stabilizing agent
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- Enzymes And Modification Thereof (AREA)
Abstract
The production method of coated granular phytase includes the following steps: uniformly mixing phytase and stabilizing agent, slowly adding fully-dissolved binder at the same time of shearing materials, stirring, cutting, kneading and granulating in the granulating machine to obtain granular material, boiling and drying, then using spray method to coat the granular phytase and screening so as to obtain the invented spherical coated granular phytase.
Description
Technical field
The present invention relates to a kind of production method that is used as the coated granule phytase of feed addictive.
Technical background
Phytic acid is ubiquitous a kind of ANFs (as table 1) in the plant feed, is that the phosphorus of institute's combination is called phytate phosphorus by a part inositol and six molecule phosphoric acid be combined intos.Can not secrete corresponding hydrolase in the nonruminant body, so phytate phosphorus is difficult to be utilized; In production of fodder,, need to add the Phos material in order to satisfy the phosphorus demand of animal; Simultaneously phytic acid has very strong complexing power, is difficult to the phytate that absorbed by the simple stomach animal with trace element chelated generation in the feed; Also form complex by electrical neutralization, reduce the digestibility and utilization of nutrient in the feed with protein.
Table 1: phytate phosphorus content in the feed a part raw material
| Vegetable raw material | Total phosphorus (%) | Non-phytate phosphorus (%) | Phytate phosphorus/total phosphorus |
| Corn | 0.27 | 0.12 | 55.6 |
| Wheat | 0.39 | 0.21 | 46.2 |
| Wheat bran | 1.07 | 0.24 | 77.6 |
| Rice bran | 1.43 | 0.10 | 93.0 |
| Big dregs of beans | 0.61 | 0.17 | 72.1 |
| Sesame-send cake | 1.20 | 0.31 | 74.2 |
| Rape cake | 0.96 | 0.33 | 65.6 |
Be to improve the absorptivity of animal, increasingly extensively in production of fodder used various enzyme preparations nutritional labeling and mineral matter.Phytase is a kind of reactive protein of catalytic decomposition phytate, hydrolysate is inositol and inorganic phosphate, the interpolation phytase can reduce the inorganic phosphorous sources addition more than 75% in feed, reduce of the pollution of the phosphorus of animal wastes discharging to environment, economize in raw materials cost and feed resource, have no side effect, do not exist the medicament residue of medicated premix and produce harmful effect such as drug resistance, be a kind of environmental protection and green feed additive.But phytase is often used in production of fodder, transporting procedures with powdery, loses most of vigor because of the shear action of being heated, particle pushes easily; Simultaneously, in the feed storage process, the trace element of interpolation contacts with phytase, has influenced the division center of phytase and reduces its vigor; Also in use dust is big owing to the powdery enzyme, has limited its application in pellet.
Summary of the invention
The technical problem to be solved in the present invention provides the production method of a kind of epigranular, good fluidity, film forming coated granule phytase complete, that dissolve rapidly in the little enteron aisle of animal.
The present invention solves the problems of the technologies described above with following technical scheme: phytase and stabilizing agent are mixed, and sufficient binding agent has been dissolved in slow adding when material is sheared; The material that is sheared in granulator by stir and cutting knead granulate after, granule materials enters the fluidized drying stage, starts spraying system at the later stage of drying, with granzyme bag quilt, screening then obtains the circular coated granule enzyme of 60-120 order with spray-on process.
The main component of stabilizing agent is the mixture of sucrose 75% (weight %, as follows), salt 10% and protein 15%; The main component of binding agent is a carboxymethyl cellulose.Membrane material is formed (weight ratio 1: 1: 1) by acrylic resin, shellac and hydroxyethylcellulose.
Phytase dry powder, stabilizing agent dosage (weight %) are respectively the 85.8%--90.4% and the 6.8%--12.2% of gross weight, and the enteric film material usage is 0.7%--1.6%, and the binding agent consumption is 1.2～1.25%.
The coated granule phytase that uses the inventive method to produce, membrane substance can effectively weaken the humidification of steam, reduces the moisture activity in the granzyme capsule; Compare with granular structure, round particle has reduced heating surface area, increases heat transmission resistance, improves the heat endurance of phytase; Simultaneously membrane substance can completely cut off contacting of micro-and phytase albumen in the feed, has avoided the loss of phytase vigor.Coated granule phytase of the present invention is applied in the processing of feed phytase, can reduce enzyme preparation amount, accurately controls the action site of phytase in intestines and stomach, and the stability of enzyme and the vigor of enzyme are without prejudice in the feed product of assurance interpolation enzyme preparation.And technological process is short, stability is high, particle coating rate is up to 90～95%, and the flowability of its granzyme, dispersiveness, temperature tolerance are good.
The specific embodiment
When producing coated granule phytase, phytase and the stabilizing agent that is equivalent to phytase weight 10%～15% are mixed, sufficient binding agent has been dissolved in slow adding when material is sheared; The material that is sheared in granulator through stir and cutting knead granulate after; the granule materials of basic forming enters the fluidized drying stage, starts spraying system at the later stage of drying, sprays into the enteric film material with granzyme bag quilt with spray-on process; screening obtains circular coated granule enzyme finished product then.
The main component of stabilizing agent is the mixture of 75% (weight %, as follows) sucrose, 10% salt and 15% protein.
The main component of binding agent is a carboxymethyl cellulose, and 5h prepares with deionized water before use, and compound concentration is 5.0%.
Phytase dry powder, stabilizing agent dosage (weight %) are respectively 85.8%--90.4% and 6.8%--12.2%, the enteric film material usage is 0.7%--1.6%, the binding agent consumption is 1.20～1.25%, and the enteric film material is formed (weight ratio 1: 1: 1) by acrylic resin, shellac and hydroxyethylcellulose.High-pressure atomization and aerodynamic atomization combine during spraying, are the alcohol dissolving enteric film material of 85-90% with mass percent, and the enteric film material after the atomizing evenly is bonded in particle surface, forms the coated granule enzyme.
Test data shows:
1. the time of the whole disintegrations in the animal intestinal environment of the granule phytase among the present invention is 30min, and shows the ability of very strong hydrolysis phytate.
2. the granule phytase among the present invention is behind feed granulating, and enzyme retention rate alive reaches more than 85%.The granulation condition is: moisture 17.0%, and feed grain size diameter is 3mm, pelleting temperature is 80 ℃, 75-80 ℃ of temperature retention time 5min.
Embodiment 1
Phytase powder 35kg, stabilizing agent 5.0kg, in the granulator container with rotating speed 150r/min mixing 3min, add binding agent 0.50kg, cutting speed 2500r/min, time 5min granulates, by high speed winds line mode particle being carried out full circle then in boiling drier handles, whole grain time 10min, baking temperature is regulated stage by stage: 50 ℃ of EATs, drying time 10min; EAT rises to 55 ℃ then, drying time 5min, to reduce wind-warm syndrome again be 45 ℃ and begin the film forming of spraying, dry film material usage 0.3kg, dry processing time 15min, the 60-120 order is counted the particle yield and is reached 88.5% in the products obtained therefrom, and particle begins the disintegration pH value in solution be 5.5--6.0.
Embodiment 2:
Phytase powder 40.0kg, stabilizing agent 4.0kg, with rotating speed 150r/min mixing, incorporation time 3min adds binding agent 0.55kg in the granulator container, cutting speed 1500r/min, granulation time 8min carries out full circle by high speed winds line mode to particle then and handles in boiling drier, whole grain time 10min, baking temperature is regulated stage by stage: 50 ℃ of EATs, drying time 15min; EAT rises to 55 ℃ then, drying time 5min, to reduce wind-warm syndrome again be 45 ℃ and begin the film forming of spraying, the dry film material usage is 0.5kg, dry processing time 15min, the 60-120 order is counted the particle yield and is reached 92.1% in the products obtained therefrom, and particle begins the disintegration pH value in solution be 5.8--6.0.
Embodiment 3:
Phytase powder 40kg; stabilizing agent 3.0kg; in the granulator container with rotating speed 300r/min mixing 3min; add binding agent 0.55kg; cutting speed 2500r/min; granulation time 5min; in boiling drier, particle is carried out full circle then and handle time 5min, 55 ℃ of EATs by high speed winds line mode; drying time 15min; to reduce the air intake temperature again be 45 ℃ and begin the film forming of spraying, dry film material usage 0.7kg, dry processing time 20min; the 60-120 order is counted the particle yield and is reached 90.2% in the products obtained therefrom, and particle begins the disintegration pH value in solution be 6.0.
Claims (4)
1. the production method of a coated granule phytase; it is characterized in that phytase and stabilizing agent are mixed; sufficient binding agent has been dissolved in slow adding when material is sheared; the material that is sheared in granulator by stir and cutting knead granulate after; granule materials enters the fluidized drying stage, starts spraying system at the later stage of drying, with spray-on process with granzyme bag quilt; screening obtains circular coated granule enzyme finished product then.
2. the production method of coated granule phytase as claimed in claim 1 is characterized in that each predominant quantity percentage of stabilizing agent is sucrose 75%, salt 10%, protein 15%, and consumption is 6.8%～12.2% of a gross weight.
3. the production method of coated granule phytase as claimed in claim 1, the main component that it is characterized in that binding agent is a carboxymethyl cellulose, consumption is 1.20～1.25% of a gross weight.
4. the production method of coated granule phytase as claimed in claim 1 is characterized in that the enteric film material is made up of the identical acrylic resin of weight ratio, shellac and hydroxyethylcellulose, and consumption is 0.70～1.6% of a gross weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100199035A CN1775067A (en) | 2005-11-24 | 2005-11-24 | Method for producing coated granule phytase |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100199035A CN1775067A (en) | 2005-11-24 | 2005-11-24 | Method for producing coated granule phytase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1775067A true CN1775067A (en) | 2006-05-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2005100199035A Pending CN1775067A (en) | 2005-11-24 | 2005-11-24 | Method for producing coated granule phytase |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101168734B (en) * | 2007-09-29 | 2010-06-02 | 北京昕地美饲料科技有限公司 | Coating micro-pill phytase and preparation method thereof |
| CN101892213A (en) * | 2010-07-13 | 2010-11-24 | 湖北大学 | Novel environmentally protected phytase heat stabilizer |
| CN103875923A (en) * | 2014-04-04 | 2014-06-25 | 王宏雁 | Fat coated biological enzyme or micro-ecological preparation |
| CN104543378A (en) * | 2013-10-16 | 2015-04-29 | 镇江拜因诺生物科技有限公司 | Application of phytase stabilizer in feed processing |
| CN112868913A (en) * | 2020-12-17 | 2021-06-01 | 杭州康德权饲料有限公司 | Microencapsulated feed enzyme preparation and preparation method thereof |
| CN113331306A (en) * | 2021-06-03 | 2021-09-03 | 北京中科万联科技有限公司 | Additive for improving livestock and poultry physiological function based on yucca, and preparation method and application thereof |
-
2005
- 2005-11-24 CN CNA2005100199035A patent/CN1775067A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101168734B (en) * | 2007-09-29 | 2010-06-02 | 北京昕地美饲料科技有限公司 | Coating micro-pill phytase and preparation method thereof |
| CN101892213A (en) * | 2010-07-13 | 2010-11-24 | 湖北大学 | Novel environmentally protected phytase heat stabilizer |
| CN104543378A (en) * | 2013-10-16 | 2015-04-29 | 镇江拜因诺生物科技有限公司 | Application of phytase stabilizer in feed processing |
| CN103875923A (en) * | 2014-04-04 | 2014-06-25 | 王宏雁 | Fat coated biological enzyme or micro-ecological preparation |
| CN112868913A (en) * | 2020-12-17 | 2021-06-01 | 杭州康德权饲料有限公司 | Microencapsulated feed enzyme preparation and preparation method thereof |
| CN113331306A (en) * | 2021-06-03 | 2021-09-03 | 北京中科万联科技有限公司 | Additive for improving livestock and poultry physiological function based on yucca, and preparation method and application thereof |
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