CN1771881A - Quick identification method of the addication and dependance of opium drug addict - Google Patents
Quick identification method of the addication and dependance of opium drug addict Download PDFInfo
- Publication number
- CN1771881A CN1771881A CN 200510048618 CN200510048618A CN1771881A CN 1771881 A CN1771881 A CN 1771881A CN 200510048618 CN200510048618 CN 200510048618 CN 200510048618 A CN200510048618 A CN 200510048618A CN 1771881 A CN1771881 A CN 1771881A
- Authority
- CN
- China
- Prior art keywords
- dependence
- drug
- addiction
- difference
- degree
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Eye Examination Apparatus (AREA)
Abstract
The present invention is quick identification method of the addiction and dependence of opium drug addict, and belongs to the field of medicine and biotechnology. Naloxone eye drop in 2 or 3 drops is dripped into the eye of drug addict, and after 10-40 min, the pupil diameter is measured and compared with that before naloxone is dripped. The addiction and dependence on opium drug is judged based on the diameter difference, and the difference over 5 pixels shows the existing addiction, and the difference of 5-10, 11-20 and over 21 shows the slight, middle and serious dependence separately. The said method is efficient, accurate and reliable.
Description
Technical field:
The present invention relates to a kind of method of utilizing naloxone eye drops to differentiate opium drug drug addict addiction and degree of dependence thereof fast, belong to addiction medicine and neurobiology technical field.
Background technology:
Current, banning drugs work is all paid much attention in countries in the world, and with drug detoxification as important measures.But, accurately differentiate and solve drug addict's addiction and degree of dependence thereof and define and become a difficult problem anxious to be solved.
Be commonly used to now judge that the method for drug addict's addiction is: the toxic after testing reaction of urine sample is positive; Or be positive, and detect the proof client symptom reflection that is addicted to drugs with other detection meanss (as injection " urging the addiction pin " etc.) through the toxic reaction of urine examination.Yet, the present drug addict's defining standard of China can not be effectively with suck, personnel on the needle with as yet not narcotic addicts person separate, in view of the above, even have suck, shoot up actor's addiction not, also may be forced to drug rehabilitation, the regulation of this and State Council's " way of giving up taking addictive drugs by force " is contrary.
Cunning day by day along with the drug addict, the difficulty of obtaining of drug abuse circumstantial evidence strengthens, part drug addict even disturb food or medicine to give up taking addictive drugs by force for taking shelter in evasions to take, and addiction medical experiment application cost height is urged in medicine (naltrexone or Allylnoroxymorphone) injection and it is comparatively loaded down with trivial details to operate, and has now to be accused of the practical application difficulty increasing that the drug addict differentiates confining method.
The degree that the drug addict is relied on drugs is differentiated, and the way that is adopted in China's practice at present is with 0.16～0.8mg Allylnoroxymorphone (Naloxone) intramuscular injection, urges the addiction provocative test to assist clinical diagnosis.But this method science is fully correctly distinguished its whether addiction.
A large amount of studies show that, the drugs smoker is a kind of disease of brain from the strict sense, by research to eye organ biological nature, can explore central nervous system's information processing and control mechanism with no damage, wherein the detection of the dynamic characteristic of pupil is exactly a kind of noninvasive detection method.Therefore the relation research that many scientists are devoted to take drugs always and pupil changes.Comprising a large amount of scientific informations in the dynamic changing process of pupil, science is obtained these data exactly and carried out analysis and distinguishing effectively is to carry out drugs to suck the key problem in technology that addiction and degree of dependence define.
Summary of the invention:
The object of the present invention is to provide a kind of naloxone eye drops that utilizes, can efficiently, accurately differentiate the method for opium drug drug addict addiction and degree of dependence thereof.
Principle of the present invention is: suck opioid drug (as morphine, Opium, heroin) and can cause the parasympathetic nervous excitement very soon, and then cause pupil obviously to dwindle, be so-called " needle point sample pupil " state in a period of time; After some time, if do not take in opioid drug again, the parasympathetic nervous irritability lowers, sympathetic nerve is hyperfunction, pupil increases gradually, until than the remarkable increasing of normal person and keep for a long time, until obtaining opium, dwindle again, this is obvious characteristics of opioid drug drug addict.Naloxone is the opiate receptor pure antagonist, it can block the effect of opioid compounds at acceptor site, cause the artificial drugs of interruption suddenly, bring out various withdrawal symptoms, bring out the specific variations of pupil diameter by the local action of opiate receptor antagonist, use the specificity variation of naloxone eye drops front and back pupil diameter to make science by check and analysis and differentiate, and can be used as the foundation of clinical diagnosis.
The present invention is 0.1-5mg/ml with Allylnoroxymorphone content, pH value is 6-8, tear of osmotic pressure and people etc. oozes or equates with 0.91% sodium chloride solution osmotic pressure is that the Allylnoroxymorphone eye drop of 740Kpa splashes in the drug addict's who sucks opium drug the eyeball, the amount of splashing into is that 2-3 drips, after 10-40 minute the testee is detected its pupil diameter, and compare with not using the pupil diameter before the Allylnoroxymorphone eye drop, its difference can be judged drug addict's addiction and opium drug is had dependence when 5 pixels are above.Difference is when the 5-10 pixel, and degree of dependence is little; Difference is when the 11-20 pixel, in the degree of dependence; Difference is when 20 pixels are above, and degree of dependence is big.
Method of the present invention has advantages such as efficient, accurate, reliable, can be widely used in addiction and the degree of dependence thereof of judging the drug addict who sucks opium drug.
The specific embodiment:
At first the testee is detected its primary pupil diameter, splash into the Allylnoroxymorphone eye drop for then its eyeball, the content of Allylnoroxymorphone is 0.1-5mg/ml in the eye drop, and pH value is 6-8, and tear of osmotic pressure and people etc. oozes or equates to be 740Kpa with 0.91% sodium chloride solution osmotic pressure; The amount of splashing into is 2 or 3, detected later subjects's pupil diameter once more at 10 or 20 or 30 or 40 minutes, front and back are recorded pupil diameter for twice to be compared, if the latter is obviously greater than the former, its difference can be judged drug addict's addiction and opium drug is had dependence when 5 pixels are above.Difference is when the 5-10 pixel, and degree of dependence is little; Difference is when the 11-20 pixel, in the degree of dependence; Difference is when 20 pixels are above, and degree of dependence is big.
The present invention detects through thousands of surplus person-time of testees, and its accuracy rate is up to more than 99%.
Claims (1)
1, the method of a kind of quick discriminating opium drug drug addict's addiction and degree of dependence thereof, it is characterized in that with Allylnoroxymorphone content be 0.1-5mg/ml, pH value is 6-8, osmotic pressure and people's tear etc. oozes, or equate to be that the Allylnoroxymorphone eye drop of 740Kpa splashes in the drug addict's who sucks opium drug the eyeball with 0.91% sodium chloride solution osmotic pressure, the amount of splashing into is that 2-3 drips, after 10-40 minute the testee is detected its pupil diameter, and compare with not using the pupil diameter before the Allylnoroxymorphone eye drop, its difference can be judged drug addict's addiction and opium drug is had dependence when 5 pixels are above; Wherein: difference is when the 5-10 pixel, and degree of dependence is little; Difference is when the 11-20 pixel, in the degree of dependence; Difference is when 20 pixels are above, and degree of dependence is big.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510048618 CN1771881A (en) | 2005-11-10 | 2005-11-10 | Quick identification method of the addication and dependance of opium drug addict |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510048618 CN1771881A (en) | 2005-11-10 | 2005-11-10 | Quick identification method of the addication and dependance of opium drug addict |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1771881A true CN1771881A (en) | 2006-05-17 |
Family
ID=36759141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510048618 Pending CN1771881A (en) | 2005-11-10 | 2005-11-10 | Quick identification method of the addication and dependance of opium drug addict |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1771881A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104545895A (en) * | 2014-09-22 | 2015-04-29 | 中国科学院昆明动物研究所 | Method for quickly screening out drug addicts by electroencephalogram characteristics |
| CN104586386A (en) * | 2014-09-22 | 2015-05-06 | 中国科学院昆明动物研究所 | Method for rapidly screening out drug addicts by means of electroencephalogram features and pupil dynamic change features |
| CN109068974A (en) * | 2016-02-12 | 2018-12-21 | 埃德蒙·L·瓦伦丁 | Opioid with improved safety and availability feature+equipment combination product |
-
2005
- 2005-11-10 CN CN 200510048618 patent/CN1771881A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104545895A (en) * | 2014-09-22 | 2015-04-29 | 中国科学院昆明动物研究所 | Method for quickly screening out drug addicts by electroencephalogram characteristics |
| CN104586386A (en) * | 2014-09-22 | 2015-05-06 | 中国科学院昆明动物研究所 | Method for rapidly screening out drug addicts by means of electroencephalogram features and pupil dynamic change features |
| CN104545895B (en) * | 2014-09-22 | 2017-02-01 | 中国科学院昆明动物研究所 | Method for quickly screening out drug addicts by electroencephalogram characteristics |
| CN109068974A (en) * | 2016-02-12 | 2018-12-21 | 埃德蒙·L·瓦伦丁 | Opioid with improved safety and availability feature+equipment combination product |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Verebely et al. | Methadone in man: pharmacokinetic and excretion studies in acute and chronic treatment | |
| Sinha et al. | Craving for alcohol: findings from the clinic and the laboratory. | |
| Jasinski et al. | Abuse liability assessment in human subjects | |
| Shoaib et al. | Deficits in a sustained attention task following nicotine withdrawal in rats | |
| Zacny et al. | Subjective and behavioral responses to intravenous fentanyl in healthy volunteers | |
| AU2004220623A1 (en) | System and method for piercing dermal tissue | |
| Hou et al. | Neural correlates of familiarity and conceptual fluency in a recognition test with ancient pictographic characters | |
| CN1771881A (en) | Quick identification method of the addication and dependance of opium drug addict | |
| Mansky | Opiates: human psychopharmacology | |
| Heishman | 4.1 EFFECTS OF ABUSED DRUGS ON HUMAN PERFORMANCE: LABORATORY ASSESSMENT | |
| PICKWORTH et al. | 4.3 EFFECTS OF ABUSED DRUGS ON PUPILLARY SIZE AND THE LIGHT REFLEX | |
| Wibawa et al. | Retracted: Early Detection on the Condition of Pancreas Organ as the Cause of Diabetes Mellitus by Real Time Iris Image Processing | |
| Bigelow | Human drug abuse liability assessment: opioids and analgesics | |
| US6007986A (en) | Methods for anti-addictive narcotic analgesic activity screening | |
| Zilm et al. | The quantitative assessment of physical dependence on opiates | |
| CN110097012A (en) | The fatigue detection method of eye movement parameter monitoring based on N-range image processing algorithm | |
| Soyka et al. | NMDA receptor challenge with dextromethorphan–subjective response, neuroendocrinological findings and possible clinical implications | |
| CN100333798C (en) | Naloxone eye drops | |
| Korey et al. | Dependence liability of two antidiarrheals, nufenoxole and loperamide | |
| CN1806756A (en) | Method for quick determining psychology dependent degree of opium addicted person | |
| CN1629874A (en) | Method and device for quick detecting of pupil dynamic changes of drug taking people | |
| CN103877096B (en) | The application in the medicine that preparation suppresses opiates addiction and withdrawal symptom of the hydrochloric acid lorcaserin | |
| Myrsten et al. | Interaction of alcohol and reward in an achievement situation | |
| Patil et al. | Design of novel assessment techniques for opioid dependent patients | |
| McBride et al. | Use of plasma histamine levels to monitor cutaneous mast cell degranulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |