CN1757381A - Method for improving resolution of ultrasonic image-forming image, and ultrasonic contrast image-forming apparatus - Google Patents
Method for improving resolution of ultrasonic image-forming image, and ultrasonic contrast image-forming apparatus Download PDFInfo
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Abstract
A method for improving the definition of ultrasonic image features that after a low mechanical index is used for scanning, the low mechanical index is regulated to high mechanical index. An ultrasonic imaging method features that after a low mechanical index is used to scan for finishing the ultrasonic image, the contrast medium micro-bubble residual in the tissue and a high mechanical index are used for instantaneous ultrasonic imaging to obtain high-definition image of tissue. An ultrasonic imaging method for diagnosing tumor with high correctness is also disclosed.
Description
Technical field
The present invention relates to a kind of method that improves the ultrasonic contrast picture resolution; Simultaneously, the invention still further relates to a kind of ultrasonic contrast imaging method and a kind of ultrasonic contrast diagnostic method; In addition, the invention still further relates to a kind of ultrasonic contrast imaging instrument.
Background technology
Ultrasonic contrast imaging is a kind of very important technological means, can be used for studying the tissue with vascular system, for example parenchymatous organ's such as liver tumor tissues.Ultrasonic contrast is to utilize contrast agent that the back scattered echoes is strengthened, and obviously improves ultrasonic sensitive and specific technology.Kind according to parcel gas in the microvesicle is divided, and contrast agent can be divided into for two generations.First generation contrast agent microbubble contain air, second filial generation contrast agent microbubble includes noble gas.
It is representative that the sharp sound that first generation acoustic contrast agent is produced with Germany shows SHU 508 (Levovist SHU508), and this contrast agent adopts galactose parcel air microbubble.Not of uniform size, the poor stability of described bubble.Use high mechanical index (1.0～1.7) scanning and make microbubble ruptures, disintegration, thereby produce abundant high strength secondary harmonics signal of moment.Because this angiographic method microbubble destruction is more, developing time is short, and be intermittently imaging,, reduced the using value of these images so these images that obtain have tangible limitation.
Second filial generation microbubble contrast is representative with Italy sound Novi (Sonovue), includes highdensity noble gas hexafluoro sulfonium, and good stability has thin and softish adventitia.Acoustic pressure hour microvesicle size presents the periodic vibration variation with incident acoustic wave, echo signal is strengthened, when acoustic pressure is higher than 30KPa～70KPa, microvesicle is Non-Linear Vibration, produce multiple harmonic signal, adopt low mechanical index (0.04～0.1) scanning, microvesicle is difficult for shatter, resonance stabilized also produces harmonic signal, adopt the linear signal of rp pulse harmonics method and noninverting impulse method deletion tissue, extract the nonlinear second harmonic signal of microvesicle, can obtain 0～8 minute continuously real-time contrast imaging.This ultrasonic contrast imaging method can obtain to show that microvesicle is in the enhancing different with parenchymal phase of arterial phase, portal vein phase with withdraw from the image of performance and focus blood perfusion feature.
Although the appearance of second filial generation microvesicle ultrasound angiography makes ultrasonic imaging technique that revolutionary leap take place and is used widely, also there is limitation in the image that the ultrasonic contrast imaging method of utilizing second filial generation acoustic contrast agent to carry out at present obtains.For example for tumor, the image space resolving power that is obtained is lower, and is not high to the resolving power of fine structure, can not be when showing contrast characteristic the internal structure and the border of display organization well.Therefore, be starved of the method that improves the ultrasonic contrast picture resolution.
For many years, according to the features such as internal structure, form and peplos of tumor, ultrasonic examination can judge the good pernicious of tumor, and makes diagnosis to a certain degree, but since malignant tumor reach some benign tumor ultrasonogram in early days and be not true to type, so misdiagnosis rate is than higher.
In recent years, along with the Application and Development of novel microcapsular ultrasound contrast agent, the diagnosis of innocent and malignant tumour was improved.The feature that phase change can more sensitive reflection innocent and malignant tumour during the perfusion of several seconds tumors in a few minutes behind the injection of contrast medium.Along with the appearance of second filial generation microcapsular ultrasound contrast agent, the diagnosis of tumor is further enhanced.But, the image that utilizes second filial generation acoustic contrast agent that tumor is carried out ultrasonic contrast at present and obtain shows that mainly microvesicle is in the enhancing of tumor tissues capillary bed with withdraw from feature, the internal structure and the border that can not when showing blood capillary perfusion feature, show tumor well, when inside tumor blood supplied to have individual diversity XOR deformity, the etiologic diagnosis of tissue and tumor can produce difficulty.Therefore, be starved of spatial resolution higher contrast ultrasound image and formation method thereof.
Summary of the invention
At problems such as above-mentioned ultrasonic contrast image space resolving power are low, the invention provides a kind of method that improves the ultrasonic contrast picture resolution.The fine structure signal that can reflect destination organization according to the image of described method acquisition.
According to another aspect of the present invention, the invention provides a kind of ultrasonic contrast imaging method.This method is applied to the ultrasonic contrast of tumor, can obtains the image on clear reflection inside tumor structure and border.
According to another aspect of the present invention, the invention provides a kind of tumor ultrasonic contrast diagnostic method, this method is obtaining the reflection microvesicle in the enhancing of tumor tissues capillary bed and the image while of withdrawing from feature, also obtain the image on clear demonstration inside tumor structure and border, carry out comprehensive analysis and judgement according to these images, can improve the diagnosis of tumor.
According to another aspect of the present invention, the invention provides a kind of ultrasonic contrast imaging instrument.In the ultrasonic contrast of tumor, use this ultrasonic contrast imaging instrument, can obtain the image that shows the enhancing of tumor tissues capillary bed and withdraw from feature easily and accurately, also obtain clear demonstration inside tumor structure and border simultaneously, more objectively respond the image of oncological pathology feature.These images of analysis-by-synthesis can improve the etiologic diagnosis rate to tumor.
Description of drawings
Fig. 1: the suspicious liver occupy-place of ultrasonic health check-up patient's image and diagnostic result.Figure 1A, the BEUS image; Figure 1B, the CEUS image; Fig. 1 C, the AEUS image.
Fig. 2: the patient's of liver occupy-place image and diagnostic result found in ultrasonic health check-up.Fig. 2 A, the BEUS image; Fig. 2 B, the CEUS image; Fig. 2 C image, AEUS; Fig. 2 D, the specimens from pri photo.
Fig. 3: 20 years hepatitis B are found AFP rising patient's image and diagnostic result (AFP＞400ng/ml) recently.Fig. 3 A, the BEUS image; Fig. 3 B and Fig. 3 C, the CEUS image; Fig. 3 D, the AEUS image.
Fig. 4: the patient's pernicious, that check discovery tumor increases image and diagnostic result do not seen in the interior tuberosity focus of liver, CT and aspiration biopsy before 2 years.Fig. 4 A, the BEUS image; Fig. 4 B, the CEUS image; Fig. 4 C, the AEUS image.
Fig. 5: the image of 10 years hepatitis B patients and diagnostic result.Fig. 5 A, the BEUS image; Fig. 5 B, the CEUS image; Fig. 5 C, the AEUS image.
Fig. 6: gastric cancer is excised back 1 year hepatic metastases tumor patient's image and diagnostic result.Fig. 6 A, the BEUS image; Fig. 6 B, the CEUS image; Fig. 6 C, the AEUS image.
Fig. 7: breast carcinoma hepatic metastases patient's image and diagnostic result.Fig. 7 A, the BEUS image; Fig. 7 B, the CEUS image; Fig. 7 C, the AEUS image.
Fig. 8: liver occupy-place patient's image and diagnostic result found in ultrasonic generaI investigation.Fig. 8 A, the BEUS image; Fig. 8 B, the CEUS image; Fig. 8 C, the AEUS image.
Fig. 9: the multiple hemangioma patient's of liver image and diagnostic result.Fig. 9 A, the BEUS image; Fig. 9 B, the CEUS image; Fig. 9 C, the AEUS image.
Figure 10: hepatitis B medical history, ultrasonic and CT all can not get rid of virulent patient's image and diagnostic result.Figure 10 A, the BEUS image; Figure 10 B and Figure 10 C, the CEUS image; Figure 10 D, the AEUS image.
Figure 11: the image and the diagnostic result of tumor patient between hepatitis B 5 years, ultrasonic discovery Liver and kidney.Figure 11 A, the BEUS image; Figure 11 B, the CEUS image; Figure 11 C, AEUS.
Figure 12: hepatitis B 15 years and CT are diagnosed as the patient's of hepatocarcinoma image and diagnostic result.Figure 12 A, the BEUS image; Figure 12 B and 12C, the CEUS image; Figure 12 D, the AEUS image; Figure 12 E, the specimens from pri photo.
The specific embodiment
Principle of the present invention is roughly as follows: second filial generation microbubble contrast agent commonly used and low mechanical index scanning imaging can guarantee microvesicle the parenchymatous organ after one's own heart, liver, spleen, lung, kidney, especially be detained in the tissue of liver 6～8 minutes, during this period of time can continue real-time gray scale imaging.Obtain in ultrasonic contrast low mechanical index scanning imaging after the information of arterial phase, portal vein phase, parenchymal phase at once, utilize residual contrast agent microbubble in the destination organization, adopt high mechanical index immediate imaging method to carry out imaging once more, because the sound field intensity of using is higher, microvesicle is impacted, and a large amount of microvesicles produce explosion in moment, form many times second harmonic, thereby obviously strengthened microvesicle echo and the ratio of organizing echo intensity, improved the fine structure difference of tissue.Abundant high strength secondary harmonics signal has increased the contrast resolution between surrounding tissue and the tumor tissues greatly.
According to one aspect of the present invention, the invention provides a kind of method that improves the ultrasonic contrast picture resolution, this method is adjusted to high mechanical index with low mechanical index after being included in ultrasonic contrast low mechanical index scanning imaging end.Utilize the high-intensity signal that produces when residual contrast agent microbubble is broken in the destination organization, improved the resolving power of tissue morphology structure, improved picture quality greatly.
Mechanical index (MI) reflection sound field intensity is one of parameter in ultrasonic contrast imaging.When mechanical index is lower than 0.15, be called low mechanical index, preferably be lower than 0.08 mechanical index in the present invention, for example be lower than 0.07, be lower than 0.06 or be lower than 0.05 etc., more preferably 0.02～0.08, for example 0.03,0.04,0.05,0.06 and 0.07.When mechanical index is higher than 0.15, be called high mechanical index, preferred 0.4～1.6 in the present invention, for example 0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4 or 1.5.Because adopt high mechanical index, sound field intensity is higher, microvesicle is impacted, and a large amount of microvesicles produce explosion in moment, form many times second harmonic, thereby has obviously strengthened microvesicle echo and the ratio of organizing echo intensity, improves the fine structure difference of tissue.Abundant high strength secondary harmonics signal has increased the contrast resolution between surrounding tissue and the tumor tissues greatly.
In order to realize the present invention, can use second filial generation microbubble contrast agent commonly used at present, for example include but not limited to:
1. Levovist (SHU 508A; Schering, Berlin, Germany), the research report can obviously strengthen the doppler ultrasound signal, and finds that Levovist has a kind of special liver phase (liver-specificphase) effect, is about to can produce after it injects in the body liver reinforced effects of delay.
2. (Milan Italy) is a kind of sulfur hexafluoride (SF6) microbubble contrast agent to SonoVue for BR-1, BRACCO, and average diameter 2.5 μ m do not contain antiseptic.Aspect safety research, thinking does not have any difference with normal saline.
3. (St Louis is that a kind of human albumin's octafluoro propane (octafluoropropane) has the shell microbubble contrast agent MO) to Optison for FS069, Mallinckralt Medical.The microvesicle diameter is approximately 3.5 μ m, has obtained drugs approved by FDA and has been used for myocardium Ultrasonography.At present, there is formal reported literature to use this contrast agent and does liver essence enhancing radiography.
4. other (include the microvesicle of fluorocarbon gas as Sonazoid, NC100100 Nycomed, Oslo, Norway), Definity (includes the liposome microvesicle of perfluorinate propane, DuPont, Boston, MA), the Imavist (microvesicle of perfluorinate hexane gas, AF0150, Alliance Pharmac.corp.﹠amp; Schering AG), (sound wave is released the microvesicle of separating the albumin parcel, MolecularBiosystems ﹠amp to Albunex; Mallinckrodt), A1700 (Acusphere University Park at M.I.TCambridge, MA 02139), Bisphere (Point Biomedical), Imagent (Alliance), Research Agents (ImaRx) and Sonovist (SHU 563A Schering, Berlin, Germany) etc.
In addition, " ultrasonic contrast low mechanical index imaging end " of the present invention is meant and uses low mechanical index Real Time Observation focus (general 4～5 minutes), thereby obtained enough blood perfusion information, can think that the imaging of ultrasonic contrast low mechanical index finishes this moment.
In order to improve the resolving power of tissue morphology structure better, can contrast agent microbubble still remain in the destination organization during this period of time in, low mechanical index is adjusted to high mechanical index.Preferably finish back 0 minute～5 minutes, for example finish in back 1 minute, 2 minutes, 3 minutes or 4 minutes low mechanical index to be adjusted to high mechanical index in the imaging of ultrasonic contrast low mechanical index in the imaging of ultrasonic contrast low mechanical index; More preferably the imaging of ultrasonic contrast low mechanical index finishes back 0 minute～3 minutes, for example finishes in back 30 seconds, 1.5 minutes or 2.5 minutes low mechanical index to be adjusted to high mechanical index in the imaging of ultrasonic contrast low mechanical index; Further preferably finish back 0 minute～1 minute in the imaging of ultrasonic contrast low mechanical index, for example finish in back 5 seconds, 10 seconds, 15 seconds, 20 seconds, 25 seconds, 30 seconds, 35 seconds, 40 seconds, 50 seconds or 60 seconds low mechanical index to be adjusted to high mechanical index in the imaging of ultrasonic contrast low mechanical index.For the concrete numeral of high mechanical index, not special restriction is as long as in the high mechanical index scope that this area is used always, be preferably 0.4～1.6 in the present invention.
In the method for raising ultrasonic contrast picture resolution according to the present invention, described imaging be preferred pin to tumor, more preferably solid tumor comprises liver tumor, splenic tumor, pancreas tumor, tumor of kidney and ovarian tumor etc.Wherein most preferably be liver tumor and carry out imaging.The pathological changes that wherein relates to liver comprises primary hepatic carcinoma, metastatic liver cancer, hepatic haemangioma, other good pernicious occupy-place of liver.
According to another aspect of the present invention, a kind of ultrasonic contrast imaging method is provided, this method mainly comprises: injection of contrast medium; The imaging of ultrasonic contrast low mechanical index; After the imaging of ultrasonic contrast low mechanical index finishes, utilize also residual contrast agent microbubble in the destination organization, adopt high mechanical index immediate imaging method to carry out imaging once more.Described ultrasonic contrast imaging method is preferably carried out conventional ultrasonic scan imaging earlier before injection of contrast medium, and returns conventional ultrasonic scan state after the imaging of ultrasonic contrast low mechanical index finishes, and adopts high mechanical index immediate imaging method to carry out imaging once more.
In the low mechanical index imaging, the sound field energy is lower, and microvesicle is difficult for destroyed, the sustainable harmonic signal that sends; In high mechanical index imaging, the sound field energy is higher, utilizes that the ultrasound wave of energy carries out radiography and carries out imaging when being higher than microvesicle and being broken up.Described injection of contrast medium and the imaging of ultrasonic contrast low mechanical index are conventional method of the prior art.In order to improve the resolving power of tissue morphology structure better, should in destination organization, still have contrast agent microbubble residual during this period of time in, low mechanical index is adjusted to high mechanical index.
Therefore, a preferred embodiment of the present invention is to finish back 0 minute～5 minutes in the imaging of ultrasonic contrast low mechanical index, for example finish in back 1 minute, 2 minutes, 3 minutes or 4 minutes in the imaging of ultrasonic contrast low mechanical index, utilize residual contrast agent microbubble in the destination organization, adopt high mechanical index immediate imaging method to carry out imaging once more.
Another preferred embodiment of the present invention is to finish back 0 minute～3 minutes in the imaging of ultrasonic contrast low mechanical index, for example finish in back 30 seconds, 1.5 minutes or 2.5 minutes in the imaging of ultrasonic contrast low mechanical index, utilize residual contrast agent microbubble in the destination organization, adopt high mechanical index immediate imaging method to carry out imaging once more.
Another preferred embodiment of the present invention is to finish back 0 minute～1 minute in the imaging of ultrasonic contrast low mechanical index, for example finish in back 5 seconds, 10 seconds, 15 seconds, 20 seconds, 25 seconds, 30 seconds, 35 seconds, 40 seconds, 50 seconds or 60 seconds in the imaging of ultrasonic contrast low mechanical index, utilize residual contrast agent microbubble in the destination organization, adopt high mechanical index immediate imaging method to carry out imaging once more.
In ultrasonic contrast imaging method according to the present invention, described imaging be preferred pin to tumor, more preferably solid tumor comprises liver tumor, splenic tumor, pancreas tumor, tumor of kidney and ovarian tumor etc.Wherein most preferably be liver tumor and carry out imaging.The pathological changes that wherein relates to liver comprises primary hepatic carcinoma, metastatic liver cancer, hepatic haemangioma, other good pernicious occupy-place of liver.
According to another aspect of the present invention, a kind of ultrasonic contrast diagnostic method also is provided, this method comprises: injection of contrast medium; The imaging of ultrasonic contrast low mechanical index; Finishing the back in the imaging of ultrasonic contrast low mechanical index adopts high mechanical index immediate imaging method to carry out imaging once more; Diagnose according to the image that is obtained.Described ultrasonic diagnosis method is preferably carried out conventional ultrasonic scan imaging earlier before injection of contrast medium, and returns conventional ultrasonic scan state after the imaging of ultrasonic contrast low mechanical index finishes, and adopts high mechanical index immediate imaging method to carry out imaging once more.Because the sound field intensity of using is higher, microvesicle is impacted, and a large amount of microvesicles produce explosion in moment, form many times second harmonic, thereby has obviously strengthened microvesicle echo and the ratio of organizing echo intensity, improves the fine structure difference of tissue.Abundant high strength secondary harmonics signal has increased the contrast resolution between surrounding tissue and the tumor tissues greatly.So the image that is obtained not only comprises lesions showed capillary bed radiography and strengthens and withdraw from the image of feature, the image that also comprises clear lesions showed position internal structure and border characteristics, carry out comprehensive analysis and judgement according to these images, can improve the diagnosis of pathological changes.
Therefore, a preferred embodiment of the present invention is to finish back 0 minute～5 minutes in the imaging of ultrasonic contrast low mechanical index, for example the imaging of ultrasonic contrast low mechanical index finished back 1 minute, 2 minutes, 3 minutes or 4 fens clock times in, utilize residual contrast agent microbubble in the destination organization, adopt high mechanical index immediate imaging method to carry out imaging once more.
Another preferred embodiment of the present invention is to finish back 0 minute～3 minutes in the imaging of ultrasonic contrast low mechanical index, for example the imaging of ultrasonic contrast low mechanical index finished back 30 seconds, 1.5 minutes or 2.5 fens clock times in, utilize residual contrast agent microbubble in the destination organization, adopt high mechanical index immediate imaging method to carry out imaging once more.
Another preferred embodiment of the present invention is to finish back 0 minute～1 minute in the imaging of ultrasonic contrast low mechanical index, for example finished back 5 seconds, 10 seconds, 15 seconds, 20 seconds, 25 seconds, 30 seconds, 35 seconds, 40 seconds, 50 seconds or in 60 second time in the imaging of ultrasonic contrast low mechanical index, utilize residual contrast agent microbubble in the destination organization, adopt high mechanical index immediate imaging method to carry out imaging once more.
Pathological changes of the present invention is preferably tumor, and more preferably solid tumor comprises liver tumor, splenic tumor, pancreas tumor, tumor of kidney and ovarian tumor etc.Liver tumor most preferably wherein.The pathological changes that wherein relates to liver comprises primary hepatic carcinoma, metastatic liver cancer, hepatic haemangioma, other good pernicious occupy-place of liver.
The present invention also provides a kind of ultrasonic contrast imaging instrument, this ultrasonic contrast imaging instrument is by increasing the unit with clocking capability on conventional ultrasonic contrast imaging instrument, make this ultrasonic contrast imaging instrument to finish the back and manually boot timing by automatic startup timing or by button is set at the low mechanical index radiography, thereby the definite time after ultrasonic contrast low mechanical index scanning imaging finishes that guarantees adopts high mechanical index formation method to carry out imaging once more, and guarantee that this moment, probe received the signal that comprises harmonic signal and fundamental signal, thereby obtain the imaging effect that resolving power improves.Conventional ultrasonic contrast imaging instrument is meant the equipment that can be used for contrast imaging in the prior art, it can intactly provide various parameters, as the radiography time, the mechanical index and the ultrasound wave sound intensity etc., make scientific research and clinical practice data complete, and can in real time, intactly write down and store the dynamic process of ultrasonic contrast.Conventional ultrasonic contrast imaging instrument generally comprises high performance conventional ultrasonic imaging device, radiography software and radiography attachment device.Described ultrasonic contrast imaging instrument can adopt different ultrasonic contrast imaging technology, for example pulse inversion harmonic wave, microangiography, contrast agent detection technique and triggering imaging etc.
In ultrasonic contrast imaging instrument of the present invention, the unit of described startup clocking capability is preferably the unit with every minute and second clocking capability.
Above-mentioned clocking capability can increase a time set and/or the circuit of ultrasonic contrast imaging instrument is changed and/or by software approach the employed software setting of ultrasonic contrast imaging instrument realized by hardware approach on the ultrasonic contrast imaging instrument.
Use ultrasonic contrast imaging instrument of the present invention, the definite time after ultrasonic contrast low mechanical index scanning imaging finishes adopts high mechanical index formation method to carry out imaging once more easily and accurately, thereby the image that obtains to show inside tumor structure and boundary information and objectively respond the oncological pathology feature, comprehensively these images can improve the etiologic diagnosis rate to tumor.
Below be description and explanation that term carried out to occurring among the present invention:
BEUS (Before Contrast Enhanced Ultrasound) is meant preceding conventional high mechanical index scanning imaging (the being conventional ultrasonic scan imaging) method of ultrasonic contrast.
CEUS (Contrast Enhanced Ultrasound) is meant ultrasonic contrast low mechanical index scanning formation method.
AEUS (After Contrast Enhanced Ultrasound), be meant ultrasonic contrast finish after high at once mechanical index formation method.
CEUS+AEUS is meant in conjunction with the information of CEUS and the acquisition of AEUS formation method and comprehensively judges.
AFP (α-fetoprotein), be meant alpha-fetoprotein or its content.
Term " diagnosis " is meant that the correct case load of diagnosis accounts for the percentage ratio of whole diagnosed SARS case numbers.
Term " occupy-place " is meant focal lesion.
Term " dizzy levying " is meant that the low echo around the tumor shown in the ultrasonogram is encircled, and is the sign of malignant tumor.
Term " knot is levied in the knot " is meant the lesser tubercle image that occurs having certain border in bigger tumor image, constitutes the lesser tubercle sign in the greater tubercle.
Term " is inlayed and is levied ", is meant visible separation structure in the tumor.
Term " is cleaned up ", is meant that contrast agent withdraws from tumor focus.
Employed contrast agent is the second filial generation acoustic contrast agent SonoVue that Italian Bracco company produces in following examples; The ultrasonic contrast imaging instrument comprises the Technos MPX (model DU8) of Italian hundred victory companies production and the Aplio of Toshiba Corp's production etc., frequency probe 2.5MHz～5.0MHz; Wherein, embodiment 2 uses the ultrasonic contrast imaging instrument that has increased clocking capability of the present invention.For contrast agent, no longer repeat in the specific embodiment, and, then need see specific embodiment for details for instrument and frequency probe.In addition, all patients that specific embodiment relates to all sign Informed Consent Form, and agree through Ethics Committee.
Embodiment 1: the suspicious occupy-place patient's of ultrasonic health check-up imaging and diagnostic result
Use instrument to be the Aplio of Toshiba diasonograph.Method 1 (BEUS): this method is conventional high mechanical index scanning imaging before the ultrasonic contrast, promptly before administration of contrast agents, with the basic frequency is occupy-place in the 4.0MHz probe scanning liver, select the implied terms (seeing the description of described ultrasonic instrument for details) of abdominal part scanning on described ultrasonic instrument, mechanical index is that 1.4 parameter is carried out imaging.Method 2 (CEUS): this method is a ultrasonic contrast low mechanical index scanning formation method, promptly on described ultrasonic instrument, select the implied terms (seeing the description of described ultrasonic instrument for details) of ultrasonic contrast scanning, after injecting contrast agent in the human vein, is the 4.0MHz probe with the basic frequency, mechanical index is that 0.06 parameter is carried out contrast imaging.Method 3 (AEUS): this method is a high mechanical index immediate imaging method behind the ultrasonic contrast, after promptly carrying out low mechanical index scanning imaging end with said method 2, withdrawing from the radiography condition conventional ultrasonic scan condition of return method 1 in the time of 2 minutes simultaneously, is that 1.4 parameter is carried out imaging once more with mechanical index.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, lobus dexter 1.4cm equal echo occupy-place (↑), and seemingly there is strong echo peplos on the border, acatalepsia (referring to Figure 1A).
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, and the occupy-place of arterial phase lobus dexter is bulk to be strengthened, and withdraws from thereafter, meets hepatocarcinoma blood perfusion characteristics (referring to Figure 1B).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, compares with BEUS, and swollen thing scope is more clear, and can show swoons levies (↑), meets hepatocarcinoma characteristics of ultrasonographic (referring to Fig. 1 C).
Embodiment 2: the patient's of liver occupy-place imaging and diagnostic result found in ultrasonic health check-up
Use instrument to be the Aplio of Toshiba diasonograph.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 4.0MHz, and mechanical index is 1.4.Method 2 (CEUS): frequency probe is 4.0MHz, and mechanical index is 0.08.Method 3 (AEUS): when ultrasonic contrast low mechanical index scanning imaging finished back 30 seconds, frequency probe was 4.0MHz, and mechanical index is 1.4 to carry out imaging once more.Method 4: this focus is undergone surgery, and the photograph specimens from pri.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, the bar-shaped tumor of lobus sinister, and the echo inequality, the demonstration of antetheca is disturbed by near field noise, and owe on the border clear (referring to Fig. 2 A).
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, and arterial phase lobus sinister occupy-place periphery is strengthened, and internal echo does not show, diagnoses still indeterminate (referring to Fig. 2 B).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, and the lobus sinister tumor boundaries is clear, and lower edge is levied (↑) and is shown peplos like visible periphery is dizzy, and inside is the real property structure (referring to Fig. 2 C) of even equal echo.
Method 4) result and analysis: operation turns out to be liver adenocarcinoma, and periphery has fibrous capsule (↑).Pathology confirms that AEUS more can objectively respond the pathological characters (referring to Fig. 2 D) of tumor.
3: two 10 years hepatitis B of embodiment are found AFP rising patient's imaging and diagnostic result (AFP＞400ng/ml) recently
Using instrument is hundred victory company's T echnos MPX diasonographs.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 3.5MHz, and mechanical index is 0.4.Method 2 (CEUS): frequency probe is 2.5MHz, and mechanical index is 0.053.Method 3 (AEUS): when ultrasonic contrast low mechanical index scanning imaging finished back 1 minute, the employing frequency probe was 3.5MHz, and mechanical index is 0.4 to carry out imaging once more.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, and right lobe of liver echo inequality is not seen obvious tumor (referring to Fig. 3 A).
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, and arterial phase sees that bulk is strengthened kitchen range (↑) (referring to Fig. 3 B) under the tunicle; 38 seconds these intralesional contrast agent withdraw from and are low echo (↑), are typical hepatocarcinoma radiography performance (referring to Fig. 3 C).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, clear demonstration tumor under the lobus dexter tunicle, echo is inhomogeneous, and visible on every side swooning levied (↑), meets hepatocarcinoma ultrasonogram (referring to Fig. 3 D).
Embodiment before 4: two years in the liver tuberosity focus, CT and aspiration biopsy do not see that pernicious, check finds the patient's that tumor increases imaging and diagnostic result
Using instrument is hundred victory company's T echnos MPX diasonographs.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 3.5MHz, and mechanical index is 1.0.Method 2 (CEUS): frequency probe is 2.5MHz, and mechanical index is 0.053.Method 3 (AEUS): when ultrasonic contrast low mechanical index scanning imaging finished back 1 minute, the employing frequency probe was 3.5MHz, and mechanical index is 1.0 to carry out imaging once more.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, and lobus dexter occupy-place border is still clear, and internal echo is owed all, seemingly has to tie sign in the knot tendency hepatocarcinoma (referring to Fig. 4 A).
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, injects the whole reinforcement of 13 seconds arterial phase lobus dexter of contrast agent tumor, and radiography meets hepatocarcinoma sign (referring to Fig. 4 B).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, and tumor boundaries is clear, dizzy levying arranged, and knot is levied and inlayed and levy in the distinctive knot of inner clear demonstration hepatocarcinoma, rear echo strengthens slightly, tool typical case liver cancer characteristic (referring to Fig. 4 C).
The imaging and the diagnostic result of liver occupy-place found in embodiment hepatitis B patient health check-up in 5: ten years
Using instrument is hundred victory company's T echnos MPX ultrasonic scan instrument.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 3.5MHz, and mechanical index is 0.4.Method 2 (CEUS): frequency probe is 2.5MHz, and mechanical index is 0.059.Method 3 (AEUS): when ultrasonic contrast low mechanical index scanning imaging finished back 40 seconds, the employing frequency probe was 3.5MHz, and mechanical index is 0.4 to carry out imaging once more.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, the little tumor of lobus dexter, has dizzy levying at sharpness of border, and internal echo is owed evenly, and there is sound shadow the side, and the enhancing of rear echo meets liver cancer characteristic (referring to Fig. 5 A).
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, and arterial phase lobus dexter focus bulk is strengthened (↑) (referring to Fig. 5 B).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, shows the 3mm small liquefaction and necrosis kitchen range of echoless (↑) (referring to Fig. 5 C) in the tumor.Confirm through puncture at last.
Embodiment 6: gastric cancer is excised back 1 year hepatic metastases tumor patient's imaging and diagnostic result
Using instrument is hundred victory company's T echnos MPX diasonographs.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 3.5MHz, and mechanical index is 0.4.Method 2 (CEUS): frequency probe is 2.5MHz, and mechanical index is 0.055.Method 3 (AEUS): when ultrasonic contrast low mechanical index scanning imaging finished back 10 seconds, the employing frequency probe was 3.5MHz, and mechanical index is 0.4 to carry out imaging once more.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, and liver S8 district (right back leaf epimere) be several hepatic metastases cancer as seen, a bigger tumor boundaries irregularity, visible on every side small kitchen range (↑) (referring to Fig. 6 A).
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, injects contrast agent and is the bulk reinforcement in 21 seconds, and periphery strengthened significantly in 23 seconds, but lesser tubercle is not seen enhancing (referring to Fig. 6 B) around the tumor.
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, and tumor periphery and internal echo are able to obvious improvement, and the enhanced edge of radiography is carefully dizzy structure, the special mess clear display (↑) (referring to Fig. 6 C) on every side levied of dark hypoecho.
Embodiment 7: breast carcinoma hepatic metastases patient's imaging and diagnostic result
Use instrument to be Technos MPX.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 3.5MHz, and mechanical index is 0.4.Method 2 (CEUS): frequency probe is 2.5MHz, and mechanical index is 0.059.Method 3 (AEUS): when ultrasonic contrast low mechanical index scanning imaging finished back 1 minute, the employing frequency probe was 3.5MHz, and mechanical index is 0.4 to carry out imaging once more.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, shows the other multiple tumor nodule (↑) of gallbladder, and bounds is owed clear (referring to Fig. 7 A).
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, clear demonstration tumor scope, and peripheral annular is strengthened (referring to Fig. 7 B).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, and lesion boundary range is clear, is many tuberositys plocoid, S8 district (right back leaf epimere) in addition visible new kitchen range of 1cm (↑) (referring to Fig. 7 C).
Embodiment 8: liver occupy-place patient's imaging and diagnostic result found in ultrasonic generaI investigation
Using instrument is hundred victory company's T echnos MPX diasonographs.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 3.5MHz, and mechanical index is 0.4.Method 2 (CEUS): frequency probe is 2.5MHz, and mechanical index is 0.053.Method 3 (AEUS): when ultrasonic contrast low mechanical index scanning imaging finished back 30 seconds, the employing frequency probe was 3.5MHz, and mechanical index is 0.4 to carry out imaging once more.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, low echo kitchen range under the fatty liver background, and rear echo strengthens slightly, acatalepsia (referring to Fig. 8 A).
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, and arterial phase focus periphery begins to strengthen, and the centration filling, is typical hemangioma performance (referring to Fig. 8 B).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, and it is irregular that focus is, and the border is clear than BEUS, visible strong echo peplos (↑) (referring to Fig. 8 C).
Embodiment 9: the multiple hemangioma patient's of liver imaging and diagnostic result
Use instrument to be the Aplio of Toshiba diasonograph.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 4.0MHz, and mechanical index is 1.4～1.6.Method 2 (CEUS): frequency probe is 4.0MHz, and mechanical index is 0.08; Method 3 (AEUS): when ultrasonic contrast low mechanical index scanning imaging finished back 1 minute, the employing frequency probe was 4.0MHz, and mechanical index is 1.4～1.6 to carry out imaging once more.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, the other low echo nodules (△) (referring to Fig. 9 A) of strong echo nodules (↑) and gallbladder under the liver tunicle.
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, and arterial phase tunicle inferior thyroid tubercle is not strengthened (↑), and the other tuberosity bulk of gallbladder is strengthened (△) (referring to Fig. 9 B).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, and tunicle inferior thyroid tubercle echo is lower slightly, and periphery is strong echo (↑), and the other tuberosity echo of gallbladder strengthens (△) (referring to Fig. 9 C) than BEUS.
Embodiment 10: hepatitis B medical history, ultrasonic and CT all can not get rid of malignant tumor of liver patient's imaging and diagnostic result
Using instrument is hundred victory company's T echnos MPX diasonographs.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 3.5MHz, and mechanical index is 0.9.Method 2 (CEUS): frequency probe is 2.5MHz, and mechanical index is 0.057.Method 3: finish in back 1 minute in ultrasonic contrast low mechanical index scanning imaging, the employing frequency probe is 3.5MHz, and mechanical index is 0.9 to carry out imaging once more.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, and the strong echo heterogeneity of S7 focus, color ultrasound are seen blood for abundant, acatalepsia (referring to Figure 10 A).
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, and the arterial phase focus is evenly strengthened (referring to Figure 10 B); Parenchymal phase intralesional subregion is withdrawed from and is low echo, still can not get rid of pernicious (referring to Figure 10 C).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, and focus is equal echo, and interior visible thin strong acoustic echo structure is considered scar tissue, does not see obvious pernicious sign (referring to Figure 10 D).
Aspiration biopsy turns out to be FNH (focal nodular hyperplasia, focal nodular hyperplasia), has further confirmed AEUS method diagnostic accuracy of the present invention.Wherein, FNH is meant liver limitation nodositas hypertrophy or FNH, and it is subcapsular a kind of like tumor sample benign lesion easily to occur in liver.
Embodiment 11: the imaging and the diagnostic result of tumor CT mistaken diagnosis right adrenal gland tumor patient between hepatitis B 5 years, ultrasonic discovery Liver and kidney
Using instrument is hundred victory company's T echnos MPX diasonographs.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 4.5MHz, and mechanical index is 0.8.Method 2 (CEUS): frequency probe is 2.5MHz, and mechanical index is 0.059.Method 3 (AEUS): finish in back 1 minute in ultrasonic contrast low mechanical index scanning imaging, the employing frequency probe is 4.5MHz, and mechanical index is 0.8 to carry out imaging once more.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, and the inhomogeneous tumor of equal echo between kidney top and the liver right lower lobe seemingly has peplos (↑), with liver boundary is arranged, character (referring to Figure 11 A) undetermined.
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, and (left side) occupy-place arterial phase is slight reinforcement.(right side) after 2 minutes parenchymal phase degree of taking a favourable turn clean up, be thought of as perniciously, but still be difficult to determine source (referring to Figure 11 B).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, and clear demonstration inside tumor structure is levied for tying in the typical knot, and periphery is thought of as hepatocarcinoma (referring to Figure 11 C) like visible dizzy levying.
Turn out to be hepatocarcinoma through the puncture biopsy, further confirmed the correctness of AEUS detection method of the present invention.
Embodiment 12: hepatitis B 15 years and CT are diagnosed as the patient's of hepatocarcinoma imaging and diagnostic result
Use instrument to be the Aplio of Toshiba diasonograph.Concrete operations have just been done following adjustment with the method for embodiment 1: method 1 (BEUS): frequency probe is 4.0MHz, and mechanical index is 1.4～1.6.Method 2 (CEUS): frequency probe is 4.0MHz, and mechanical index is 0.08.Method 3 (AEUS): when ultrasonic contrast low mechanical index scanning imaging finished back 50 seconds, the employing frequency probe was 4.0MHz, and mechanical index is 1.4～1.6 to carry out imaging once more.Method 4: this focus is undergone surgery, and the photograph specimens from pri.
The result and the analysis of method 1 (BEUS): image space resolving power height, but the contrast resolution is low, the big tumor of right back leaf single-shot, and owe on the border clear (referring to Figure 12 A).
The result and the analysis of method 2 (CEUS): image comparison resolving power height, but spatial resolution is low relatively, and the right back leaf tumor of arterial phase scope obviously increases, and is Heterogeneous enhancement (referring to Figure 12 B); The right back leaf tumor epithelial cell phase is cleaned up (referring to Figure 12 C).
The result and the analysis of method 3 (AEUS): image space resolving power height, the contrast resolution is also higher, and tumor is many tuberositys plocoid, shows a plurality of moonlet kitchen ranges (↑) (referring to Figure 12 D) around it.
Method 4: most moonlet kitchen ranges conform to the AEUS finding (referring to Figure 12 E) around operation and pathology master's tumor kitchen range.
Embodiment 13: the application of more different formation methods in the diagnosis of liver occupy-place focus
By 105 129 liver occupy-places of example focuses are detected, and through the perspective study of BEUS, CEUS and three kinds of methods of AEUS.Wherein, may can be with reference to embodiment 1-5 for the diagnostic method of primary hepatic carcinoma, 11 or 12 employed methods; May for the diagnostic method of metastatic liver cancer can be with reference to embodiment 6 or 7 employed methods; May for the diagnostic method of hepatic haemangioma can be with reference to embodiment 8 or 9 employed methods; May for the diagnostic method of other occupy-place of liver can be with reference to embodiment 10 employed methods.The result shows that the diagnosis (CEUS+AEUS) of the inventive method increases by 7% than independent ultrasonic contrast low mechanical index scanning (CEUS); Diagnosis than conventional high mechanical index scanning (BEUS) before the simple ultrasonic contrast has improved 40.3% (table 1).
Table 1 105 examples, 129 liver occupy-places focus immediate imaging diagnostic results (%)
| Disease | The kitchen range number | BEUS diagnosis (making a definite diagnosis the kitchen range number) | CEUS diagnosis (making a definite diagnosis the kitchen range number) | CEUS+AEUS diagnosis (making a definite diagnosis the kitchen range number) |
| Other the optimum occupy-place of primary hepatic carcinoma metastatic liver cancer hepatic haemangioma liver | 62 29 32 6 | (51.6 32 kitchen range) 62.1 (18 kitchen range) 53.1 (17 kitchen ranges) 16.7 (1 kitchen range) | (88.7 55 kitchen range) 86.0 (25 kitchen range) 90.6 (29 kitchen ranges) 33.3 (2 kitchen range) | (93.5 58 kitchen range) 93.1 (26 kitchen range) 96.9 (31 kitchen ranges) 83.3 (5 kitchen range) |
| Amount to | 129 | (52.7 68 kitchen range) | (86.0 111 kitchen range) | (93.0 120 kitchen range) |
The present invention is not limited to above-mentioned specific embodiment, and embodiment only is used to illustrate some aspect of the present invention.The method or the instrument that are equal on the function comprise within the scope of the invention.In fact, according to description and the accompanying drawing of this paper, be that conspicuous, such change is also included within the scope of claim of the present invention to those skilled in the art based on various changes of the present invention.
Industrial applicibility
The method of raising ultrasonoscopy resolving power of the present invention has been improved the conventional ultrasound images quality greatly, can obtain the image on clear demonstration inside tumor structure and border. Behind the ultrasonic contrast of the present invention at once the information that obtains of high mechanical index formation method and Ultrasonic Diagnosis method increased the diagnosis confidence of doctor to ultrasonic contrast, and improve the diagnosis of ultrasonic contrast. Through 129 innocent and malignant tumour ultrasonic contrasts are used, confirm that by the inventive method compare with ultrasonic contrast low mechanical index scanning imaging diagnosis method, diagnosis effect obviously improves, compare with conventional high mechanical index scanning imaging diagnosis method before the ultrasonic contrast, diagnosis significantly improves. Ultrasonic contrast imaging instrument of the present invention is simple to operate, after the enhancing and exit feature that obtain the tumor-microvessel bed, the definite time after ultrasonic contrast low mechanical index scanning imaging finishes adopts high mechanical index formation method to carry out re-imaging easily and accurately, thereby obtains the image on clear demonstration inside tumor structure and border. In sum, illustrate that the present invention has important practical.
Claims (10)
1. method that improves the ultrasonic contrast picture resolution, this method are included in after the imaging of ultrasonic contrast low mechanical index finishes, and low mechanical index is adjusted to high mechanical index.
2. the method for raising ultrasonic contrast picture resolution as claimed in claim 1, wherein, described low mechanical index is adjusted to high mechanical index is to finish in back 0 minute～5 minutes in the imaging of ultrasonic contrast low mechanical index, in preferred 0 minute～3 minutes, carries out in more preferably 0 minute～1 minute.
3. the method for raising ultrasonic contrast picture resolution as claimed in claim 1 or 2, wherein, described imaging is at tumor, is preferably solid tumor, more preferably liver tumor is carried out imaging.
4. ultrasonic contrast imaging method, this method comprises: injection of contrast medium; The imaging of ultrasonic contrast low mechanical index; After the imaging of ultrasonic contrast low mechanical index finishes, adopt high mechanical index immediate imaging method to carry out imaging once more.
5. ultrasonic contrast imaging method as claimed in claim 4, this method is carried out conventional ultrasonic scan imaging earlier before injection of contrast medium, and after the imaging of ultrasonic contrast low mechanical index finishes, return conventional ultrasonic scan state, adopt high mechanical index immediate imaging method to carry out imaging once more.
6. as claim 4 or 5 described ultrasonic contrast imaging methods, wherein, described imaging once more is to finish in back 0 minute～5 minutes in the imaging of ultrasonic contrast low mechanical index, in preferred 0 minute～3 minutes, carries out in more preferably 0 minute～1 minute.
7. as claim 4 or 5 described ultrasonic contrast imaging methods, wherein, described imaging is at tumor, is preferably solid tumor, and more preferably liver tumor is carried out imaging.
8. ultrasonic contrast imaging instrument, this ultrasonic contrast imaging instrument have in the imaging of ultrasonic contrast low mechanical index and finish the functional unit that the back starts timing.
9. ultrasonic contrast imaging instrument as claimed in claim 8, the functional unit of wherein said startup timing are the unit with every minute and second clocking capability.
10. ultrasonic contrast imaging instrument as claimed in claim 8 or 9, the functional unit of wherein said startup timing increases a time set by hardware approach and/or the circuit of ultrasonic contrast imaging instrument is changed and/or by software approach the employed software setting of conventional ultrasonic contrast imaging instrument realized on conventional ultrasonic contrast imaging instrument.
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| CN101283915B (en) * | 2007-04-13 | 2012-01-11 | Ge医疗系统环球技术有限公司 | Ultrasonic diagnostic apparatus |
| CN101861600B (en) * | 2007-11-14 | 2012-11-28 | 皇家飞利浦电子股份有限公司 | System and method for quantitative 3D CEUS analysis |
| CN109965905A (en) * | 2019-04-11 | 2019-07-05 | 复旦大学 | A kind of radiography region detection imaging method based on deep learning |
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| GB9808599D0 (en) * | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or realting to contrast agents |
| JP2003102727A (en) * | 2001-10-01 | 2003-04-08 | Toshiba Corp | Ultrasonic diagnostic equipment and image reproducing device |
| JP3748848B2 (en) * | 2002-11-11 | 2006-02-22 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | Ultrasonic diagnostic equipment |
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| CN101283915B (en) * | 2007-04-13 | 2012-01-11 | Ge医疗系统环球技术有限公司 | Ultrasonic diagnostic apparatus |
| CN101861600B (en) * | 2007-11-14 | 2012-11-28 | 皇家飞利浦电子股份有限公司 | System and method for quantitative 3D CEUS analysis |
| CN109965905A (en) * | 2019-04-11 | 2019-07-05 | 复旦大学 | A kind of radiography region detection imaging method based on deep learning |
| CN109965905B (en) * | 2019-04-11 | 2020-02-11 | 复旦大学 | Contrast region detection imaging method based on deep learning |
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