CN1742791A - Heat-clearing toxifying soft capsule and preparing method - Google Patents
Heat-clearing toxifying soft capsule and preparing method Download PDFInfo
- Publication number
- CN1742791A CN1742791A CN 200510094620 CN200510094620A CN1742791A CN 1742791 A CN1742791 A CN 1742791A CN 200510094620 CN200510094620 CN 200510094620 CN 200510094620 A CN200510094620 A CN 200510094620A CN 1742791 A CN1742791 A CN 1742791A
- Authority
- CN
- China
- Prior art keywords
- soft capsule
- cream powder
- dried cream
- qingrejiedu
- hydroxybenzoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a soft capsule with the function of clearing away heat and removing toxic material and its preparation method. Its composition includes dandelion extract powder, bushy knotweed root extract powder, patrinia extract powder and barbat skullcap extract powder. Said invention also provides the concrete steps of said preparation method.
Description
Technical field:
The present invention relates to a kind of heat-clearing and detoxifying herb soft capsule and preparation thereof.
Background technology:
With Herba Taraxaci, Rhizoma Polygoni Cuspidati etc. is that the existing dosage form of the heat-clearing and detoxifying herb of Main Ingredients and Appearance is granule and capsule.Have and carry, take inconvenience, the effective ingredient stripping waits problem slowly.
Summary of the invention:
Technical problem to be solved by this invention is to avoid above-mentioned existing in prior technology weak point, provides a kind of effective ingredient stripping fast, and steady quality carries, the 'Qingrejiedu ' soft capsule and the preparation method of taking convenience.
The technical scheme that technical solution problem of the present invention is adopted is:
'Qingrejiedu ' soft capsule of the present invention is to be made of medicinal liquid and softgel shell, it is characterized in that described medicinal liquid is an effective ingredient with the medicine dried cream powder, and contains pharmaceutic adjuvant, contains medicine dried cream powder≤0.400 gram in every medicinal liquid;
Described medicine dried cream powder is by weight with Herba Taraxaci 2-5 part, Rhizoma Polygoni Cuspidati 2-5 part, Sonchus brachyotus DC. 2-4 part, Herba Scutellariae Barbatae 1-3 part, decoct with water extraction jointly, concentrate, vacuum drying and;
Include in diluent, suspending agent and the antioxidant one or more in the described pharmaceutic adjuvant;
The preparation liquid of described softgel shell contains 10 parts in gelatin by weight, 3.2～3.6 parts of glycerol, 9.0～10.0 parts in water and antiseptic 0.03.
The preparation method of 'Qingrejiedu ' soft capsule of the present invention is to operate as follows:
A, gelatin, G ﹠ W are mixed in proportion, add antiseptic and food coloring, the heating in water bath dissolving is stirred simultaneously under 80-90 ℃ of temperature, and after the vacuumize degassing, 60-70 ℃ of insulation is standby;
B, pharmaceutic adjuvant is put into beaker, heated and stirred makes its mixing, adds the medicine dried cream powder, stirs, and leaves standstill to make its degassing back standby;
C, the medicinal liquid for preparing is poured in the medicinal liquid bucket, suppressed soft capsule with mould.
Compared with the prior art, 'Qingrejiedu ' soft capsule agent bioavailability height of the present invention is taken and easy to carry, and the effective ingredient stripping is fast, onset in time, and the quality of the pharmaceutical preparations is reliable and stable.
The specific embodiment:
In the present embodiment, be with medical material Herba Taraxaci, Rhizoma Polygoni Cuspidati, Sonchus brachyotus DC. and Herba Scutellariae Barbatae, decoct with water twice jointly, 2 hours for the first time, 1 hour for the second time, concentrate behind the merge extractive liquid,, and get at 60 ℃ of following vacuum dryings as the medicine dried cream powder of medicine active ingredient.
In concrete the enforcement, by weight, each crude drug of distinguishing the flavor of can according to the form below is listed be drawn materials:
| Group | Herba Taraxaci | Rhizoma Polygoni Cuspidati | Sonchus brachyotus DC. | Herba Scutellariae Barbatae |
| ?1 | ?2-5 | ?2-5 | ?2-4 | ?1-3 |
| ?2 | ?3 | ?3 | ?3 | ?1.5 |
| ?3 | ?3 | ?3 | ?4 | ?2 |
| ?4 | ?4 | ?2 | ?3 | ?1 |
| ?5 | ?4 | ?3 | ?4 | ?2 |
In the present embodiment, pharmaceutic adjuvant is one or more in diluent, cosolvent, suspending agent and the antioxidant.In concrete the enforcement, pharmaceutic adjuvant and antiseptic can have following selection:
Diluent is one or more in Polyethylene Glycol, vegetable oil, the mineral oil;
Suspending agent be in ethylhydroxyethylcellulose, chitin, chitose, methylcellulose, ethyl cellulose, agar, tragacanth, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, the Cera Flava one or more;
Antioxidant is one or more in sodium sulfite, sodium pyrosulfite, potassium metabisulfite, ethylenediaminetetraacetic acid, disodium edta, succinic acid, citric acid, hydroquinone, malic acid, ascorbic acid, sodium ascorbate, inositol, alpha-tocopherol, the α-tocopheryl acetate;
Antiseptic is one or more in Oleum Caryophylli, sorbic acid, sorbic acid methyl ester, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, butyl p-hydroxybenzoate calcium, Sodium Methyl Hydroxybenzoate, the Sodium Propyl Hydroxybenzoate.About softgel shell:
Softgel shell in the present embodiment is applicable to the oiliness medicinal liquid.
Gelatin, glycerol, water proportioning are difficult to grasp in the prescription of softgel shell.The amount of glycerol is too many, and softgel shell is softer, than being easier to extrusion; Amounts of glycerol very little, softgel shell is harder, crisp, influences the quality stability and the disintegration time of soft capsule.Carry out detailed experimental study by proportioning, obtain a proportioning preferably glycerol, gelatin and water.
Gelatin, glycerol, water are put in the water-bath glue jar according to a certain percentage, 85 ℃～90 ℃ heating in water bath dissolvings add an amount of ethyl hydroxybenzoate and an amount of pigment, stir 2 hours, after the vacuumize degassing, 65 ℃ of insulation standing over night, second day, the moulding ball, the room temperature removal moisture drying, keep sample and investigate three months, investigate soft capsule outward appearance and physical property, the result is as follows:
| Index/content of the test | 0.01 part of 10 portions of antiseptic of 3.0 parts of water of 10 parts of glycerol of gelatin | 0.02 part of 10 parts of rotten agent of 3.5 parts of water of 10 parts of glycerol of gelatin | 0.01 part of 9 portions of antiseptic of 3.0 parts of water of 10 parts of glycerol of gelatin | 0.01 part of 9～10 portions of antiseptic of 32～3.6 parts of water of 10 parts of glycerol of gelatin | 0.01 part of gelatin 10kg glycerol 4.0kg water 9kg antiseptic |
| Softgel shell outward appearance and physical property | Easily break | Softer, easily break | Too hard | Suitable | Too soft |
By above test, can reach a conclusion, should contain by weight in the prescription of softgel shell: 10 parts in gelatin, 3.2～3.6 parts of glycerol, 9～10 parts in water.
About medicinal liquid:
Medicinal liquid as effective ingredient, and contains pharmaceutic adjuvant with effective dose of medicine thing dried cream powder, and wherein, medicinal liquid contains medicine dried cream powder≤0.400 in every by weight.
The used diluent of the softgel shell of soft capsule decision medicinal liquid can not be with ethanol and the bigger organic solvent of some toxicity.When selecting vegetable oil substrate, medicine dried cream powder and be insoluble to vegetable oil.When selecting polyethylene glycols substrate, the medicine dried cream powder dissolves in the Polyethylene Glycol-400 and becomes solution, but mobile poor, should not suppress.When the medicine dried cream powder is suspended in the vegetable oil, after having selected multiple suspending agent for use, all find sedimentation phenomenon.Finally select for use Cera Flava to make suspending agent, effect is comparatively desirable, and long-time placement is more stable.Consider the size of economic factor and selected every ball easy to prepare, finally be by the definite liquid formula of gram/grain.
Medicine dried cream powder≤0.400, vegetable oil 0.300-0.750, Cera Flava 0.003-0.015.
But concrete value is:
Reyanning dried cream powder 0.300, vegetable oil 0.400, Cera Flava 0.005, also adding preservative agent 0.0001 in addition.
At this liquid formula, be that the prescription that the softgel shell of unit prepares liquid can be gelatin 0.200, glycerol 0.070, water 0.200, food coloring 0.0012 with gram/grain.
Soft capsule preparation tool step is in the present embodiment:
A, gelatin, G ﹠ W are mixed in proportion, add antiseptic and food coloring, the heating in water bath dissolving is stirred simultaneously under 80-90 ℃ of temperature, and after the vacuumize degassing, 60-70 ℃ of insulation is standby;
B, vegetable oil and Cera Flava are put into beaker, heated and stirred makes its mixing, adds the medicine dried cream powder, stirs, and leaves standstill to make its degassing back standby;
C, the medicinal liquid for preparing is poured in the medicinal liquid bucket, suppressed soft capsule with mould.
Soft capsule after compacting is finished at room temperature dry two days.Reject appearance poor capsule, with the capsule washing, remove the lubricating oil in the pelleting process, again in 24 ℃ dry two days down, the 'Qingrejiedu ' soft capsule semi-finished product, the qualified packing of quality testing, labeling, packing, promptly get the 'Qingrejiedu ' soft capsule finished product.
Preparation is a unit with gram/grain as stated above, and liquid formula also can be
Prescription 1: medicine dried cream powder 0.30, vegetable oil 0.30, Cera Flava 0.003
Prescription 2: medicine dried cream powder 0.30, vegetable oil 0.35, Cera Flava 0.005
Prescription 3: medicine dried cream powder 0.30, vegetable oil 0.30, Cera Flava 0.005
Prescription 4: medicine dried cream powder 0.30, vegetable oil 0.35, Cera Flava 0.015, hydroxypropyl emthylcellulose 0.015.
In above-mentioned prescription 4, add the raising that hydroxypropyl emthylcellulose helps constant product quality.
Claims (6)
1, 'Qingrejiedu ' soft capsule is made of medicinal liquid and softgel shell, it is characterized in that described medicinal liquid is an effective ingredient with the medicine dried cream powder, and contains pharmaceutic adjuvant, contains medicine dried cream powder≤0.400 gram in every medicinal liquid;
Described medicine dried cream powder is by weight with Herba Taraxaci 2-5 part, Rhizoma Polygoni Cuspidati 2-5 part, Sonchus brachyotus DC. 2-4 part, Herba Scutellariae Barbatae 1-3 part, decoct with water extraction jointly, concentrate, vacuum drying and;
Include in diluent, suspending agent and the antioxidant one or more in the described pharmaceutic adjuvant;
The preparation liquid of described softgel shell contains 10 parts in gelatin by weight, 3.2～3.6 parts of glycerol, 9.0～10.0 parts in water and antiseptic 0.03.
2, 'Qingrejiedu ' soft capsule according to claim 1 is characterized in that:
Described diluent is one or more in Polyethylene Glycol, vegetable oil, the mineral oil;
Described suspending agent be in ethylhydroxyethylcellulose, chitin, chitose, methylcellulose, ethyl cellulose, agar, tragacanth, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, the Cera Flava one or more;
Described antioxidant is one or more in sodium sulfite, sodium pyrosulfite, potassium metabisulfite, ethylenediaminetetraacetic acid, disodium edta, succinic acid, citric acid, hydroquinone, malic acid, ascorbic acid, sodium ascorbate, inositol, alpha-tocopherol, the α-tocopheryl acetate;
Described antiseptic is one or more in Oleum Caryophylli, sorbic acid, sorbic acid methyl ester, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, butyl p-hydroxybenzoate calcium, Sodium Methyl Hydroxybenzoate, the Sodium Propyl Hydroxybenzoate.
3, 'Qingrejiedu ' soft capsule according to claim 1 is characterized in that with gram/grain being that the liquid formula of unit is:
Medicine dried cream powder≤0.400, vegetable oil 0.300-0.750, Cera Flava 0.003-0.015.
4, 'Qingrejiedu ' soft capsule according to claim 1 is characterized in that with gram/grain being that the liquid formula of unit is:
Medicine dried cream powder 0.30, vegetable oil 0.35, Cera Flava 0.015, hydroxypropyl emthylcellulose 0.015.
5, 'Qingrejiedu ' soft capsule according to claim 1 is characterized in that with gram/grain being that the prescription that the softgel shell of unit prepares liquid is: gelatin 0.200, glycerol 0.070, food coloring 0.0012, water 0.200, antiseptic.
6, the preparation method of the described 'Qingrejiedu ' soft capsule of a kind of claim 1 to 5 is characterized in that operating as follows:
A, gelatin, glycerol, water are mixed in proportion, add antiseptic and food coloring, the heating in water bath dissolving is stirred simultaneously under 80-90 ℃ of temperature, and after the vacuumize degassing, 60-70 ℃ of insulation is standby;
B, pharmaceutic adjuvant is put into beaker, heated and stirred makes its mixing, adds the medicine dried cream powder, stirs, and leaves standstill to make its degassing back standby;
C, the medicinal liquid for preparing is poured in the medicinal liquid bucket, suppressed soft capsule with mould.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510094620 CN1742791A (en) | 2005-09-30 | 2005-09-30 | Heat-clearing toxifying soft capsule and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510094620 CN1742791A (en) | 2005-09-30 | 2005-09-30 | Heat-clearing toxifying soft capsule and preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1742791A true CN1742791A (en) | 2006-03-08 |
Family
ID=36138416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510094620 Pending CN1742791A (en) | 2005-09-30 | 2005-09-30 | Heat-clearing toxifying soft capsule and preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1742791A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113456697A (en) * | 2020-03-30 | 2021-10-01 | 洛阳惠中兽药有限公司 | Method for preparing stable polydatin-containing extract and extract thereof |
-
2005
- 2005-09-30 CN CN 200510094620 patent/CN1742791A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113456697A (en) * | 2020-03-30 | 2021-10-01 | 洛阳惠中兽药有限公司 | Method for preparing stable polydatin-containing extract and extract thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1150889C (en) | Oral Micro-emulsion composition of silybin | |
| US20190350876A1 (en) | Oral thin films comprising plant extracts and methods of making and using same | |
| EP2832349B1 (en) | Lactate-based fulvestrant or fulvestrant derivative oily preparation and preparation method thereof | |
| CN109481414B (en) | Adeladol soft capsule | |
| CN1742791A (en) | Heat-clearing toxifying soft capsule and preparing method | |
| US9393230B2 (en) | Pharmaceutical composition on the basis of phyto-nutrients with increased bioavailability, having anti-tumor activity, and method for producing said composition (alternatives) | |
| CN1308030C (en) | Medicine combination containing valid part of Ruyi Jinhuangsan and its preparing method | |
| CN1742813A (en) | Soft capsule for treating acute and chronic pyelonephritis and prostatitis and preparing method | |
| JPH0255404B2 (en) | ||
| CN1742868A (en) | Soft capsule for promoting blood circulation and removing blood stasis and promoting circulation of qi and relieving pain, and preparing method | |
| CN101862319A (en) | Docetaxel combination for injection and preparation method thereof | |
| Laily Kurniawati et al. | The effects of root extract Ruellia tuberosa L on histopathology and malondialdehyde levels on the liver of diabetic rats | |
| CN1069520C (en) | Breviscapine soft capsule and its production method | |
| CN100544707C (en) | panacea grass soft capsule and production method thereof | |
| CN100415229C (en) | Itraconazole soft capsule, and its prepn. method | |
| CN108379339B (en) | Preparation method of multi-target antibacterial acne-removing gel | |
| CN1569121A (en) | Medicinal capsule of Chinese clinopodium herb for and its preparing process | |
| CN1069519C (en) | Bulleyaconitine A soft capsule and its production method | |
| CN1064258C (en) | Soft capsule of notoginseng extract and its preparing process | |
| CN105395471A (en) | External use emulsifiable paste for treating skin diseases and with econazole nitrate as active component and preparation method | |
| CN1939403A (en) | Production of compound Danshen root injection | |
| CN1634428A (en) | Ginkgo leaf soft capsule and preparation technique thereof | |
| CN1543942A (en) | Haw leaf general flavone soft capsule and preparation thereof | |
| CN1481883A (en) | Fleabane soft capsule formulation and its preparation method | |
| CN1449765A (en) | Puerarin soft capsule pharmaceutics and preparation process thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |