CN1739710A - Medicine for treating rheumarthritis and traumatic injury pain and its prpen - Google Patents
Medicine for treating rheumarthritis and traumatic injury pain and its prpen Download PDFInfo
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- CN1739710A CN1739710A CN 200510036693 CN200510036693A CN1739710A CN 1739710 A CN1739710 A CN 1739710A CN 200510036693 CN200510036693 CN 200510036693 CN 200510036693 A CN200510036693 A CN 200510036693A CN 1739710 A CN1739710 A CN 1739710A
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Abstract
The medicine is prepared with 24 kinds of Chinese medicinal materials including girald daphne, angelica, red peony root, nutagrass flatsedge rhizome, notopterygium, etc. The medicine has expelling wind and cold evils, relaxing the muscles and joints, and promoting blood circulation, and is used mainly in treating pain in muscles and joints, numb limbs, pain waist and knees, rheumatic joint pain and swelling, traumatic injury, etc. It has fast and high effect and no bad reaction.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of rheumatic arthritis and traumatic injury pain, being specifically related to a kind of is the Chinese patent medicine of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology
Rheumatism is recorded in " the Huang di's Canon of Medicine element is asked a numbness opinion piece of writing " the earliest in motherland's medical science, belong to arthromyodynia, " wet three gas of wind and cold are assorted extremely, close and be numbness also.Its migratory BI-syndrome caused mainly by pathogenic wind; BI-syndrome caused mainly by pathogenic cold being called painful BI; The dampness victor be damp arthralgia also." so " pathogen is gathered, its gas must be empty "; thus positive QI-insufficiency, exopathogen invasion are arthromyodynia take place or lose the day after tomorrow support, the tired utmost point, sexual strain, puerperal crossed lose blood etc. and to cause suffering from a deficiency of the kidney; heresy that wind and cold is wet taken advantage of a weak point in opponent's defence and invaded kidney to the marrow deeply; blood apoplexy cold-damp is coagulated resistance, numbness resistance meridians joint, with the passing of time muscles and bones mistake is supported; injury of tendon and muscle bone damage, gradually causes arthralgia, limitation of activity very then.Rheumatism is common disease of a class and frequently-occurring disease in China, and frequently-occurring disease is latent attacks, the state of an illness is mixed, the course of disease is touching, prognosis mala, serious threat people's life and health.The disease kind that rheumatism relates to is in extensive range, all diseases that influences joint, bone, muscle and relevant soft tissue or connective tissue are all included common person such as rheumatic arthritis, rheumatoid arthritis, ankylosing spondylitis, sjogren syndrome, systemic lupus erythematosus (sle), dermatomyositis, osteoarthritis etc.Rheumatic arthritis be it is generally acknowledged relevant with A family hemolytic streptococcal infection, it is a kind of inflammation disease of the acute or chronic whole body connective tissue of outbreak repeatedly that causes after the upper respiratory tract infection due to the Hemolytic streptococcus, the most remarkable with heart and joint involvement. because the primary disease morbidity is anxious, sick just many serve as mainly to show with whole body heating and significant redness and swelling of joints burning pain, if the untimely effective method of taking is treated, cause great misery not only can for patient's body and mind, also can delay treatment, make it into the gesture that the delay difficulty heals, cause chronic rheumatic arthritis, some conditions of patients can be developed to heart, to threat to life.Rheumatoid arthritis is a kind of autoimmune disease, is because immune system dysfunction causes the result of joint synovitis disease.Pain or sense of discomfort promptly appear in the muscle of some patient before Changes in weather, patient's private prosecution " being meteorological observatory on one's body ".This class disease can cause joint injury, pain, swelling, stiff and distortion, and makes the range of activity in impaired joint limited and lopsided, has a strong impact on patient's physical and mental health and quality of life.
The sick normal infringement child of this class is with young, and according to the foreign literature report, the age of onset minimum is 6 weeks only, maximum 80 years old.The domestic people of having reports that reckling is 10 months, is 77 years old to the maximum.With 30～50 years old for sending out age level well.Women's sickness rate is higher, is about 2～3 times of male, is sending out among the patient more than 50 years old, and men and women's sickness rate does not have significant difference.The whole world has 3.55 hundred million arthritics, and wherein 1.9 hundred million suffer from osteoarthritis, surpasses 1,650 ten thousand people and suffers from rheumatic arthritis.And as the No.1 disabling condition in the world, its course of disease reaches 2 years persons, and the osteoclasia rate is 50%, and the person of being in a bad way can lose the whole show ability, and the life-span approximately shortens 10～15 years.
For the treatment of rheumatic arthritis, the most frequently used medicine of doctor trained in Western medicine is non-steroidal anti-inflammatory medicine (NSAIDs) at present, as aspirin, ibuprofen, diclofenac and naproxen etc.But evidence suggests, often use NSAID (non-steroidal anti-inflammatory drug) to have serious side effects, increase gastrointestinal tract burst soup and complication such as hemorrhage, exist various danger too even each life cycle is long.Aspect the Chinese medicine treatment, formed complete theoretical system from ancient times to the present gradually, ancient Chinese medicine doctor is through experience accumulation constantly, removing normal invigorating the kidney and strengthening the bones, cold relieving, removing dampness, the wind that looses of adopting clinically treats on the basis, more pay attention to activating blood circulation to dissipate blood stasis and dredge the collateral, make that kidney qi is prosperous, essence and blood foot, marrow bone growth promoting are strong, the smooth ruton of blood, joint muscle arteries and veins are moistened fosterly, have obtained good effect.Or use the method that innerwear outer treatment combines, can play treating both the principal and the secondary aspects of a disease at the same time, disease controlling, the purpose of conditioning viscera negative and positive.
Summary of the invention
The object of the present invention is to provide a kind of good effect, instant effect and do not have the treatment rheumatic arthritis of obvious toxic-side effects and the medicine of traumatic injury pain.
Another object of the present invention is to provide the preparation method of this medicine.
The invention provides a kind of medicine for the treatment of rheumatic arthritis and traumatic injury pain, is the medicament of being made by the following weight proportion raw material:
Daphne giraldii Nitsche 12～13 Radix Angelicae Sinensis 7.5～8.0 Radix Paeoniae Rubra 7.5～8.0 Rhizoma Cyperis 7.5～8.0
Rhizoma Et Radix Notopterygii 7.5～8.5 Herba Asaris 7.5～7.8 Rhizoma Atractylodis Macrocephalaes 7.5～8.0 Radix Saposhnikoviaes 7.5～8.0
The Radix Angelicae Dahuricae 7.5～8.1 Radix Angelicae Pubescentiss 7.5～8.1 Semen Persicaes 7.5～8.1 Radix Achyranthis Bidentataes 7.5～8.1
Cortex Cinnamomi 3.0～4.5 Ramulus Cinnamomi 3.0～4.0 Rhizoma Arisaematiss 1.8～2.0 Herba Ephedraes 1.8～2.1
Pheretima 1.8～2.1 Radix Aconitis 1.8～2.0 Radix Aconiti Kusnezoffii 2.5～2.8 Flos Carthamis 2.5～3.0
Olibanum 1.1～1.5 Myrrhas 1.1～1.5 Borneolum Syntheticums 0.3～0.5 Flos Caryophylli 0.6～1.0
The above-mentioned medicine that is used for the treatment of rheumatic arthritis and traumatic injury pain can be made said multiple dosage form on the pharmaceutics, as plaster, cataplasma, capsule or pill etc.
Above-mentioned materials of weight proportions is made the method for plaster of the present invention, may further comprise the steps:
(1), gets Daphne giraldii Nitsche, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Cyperi, Rhizoma Et Radix Notopterygii, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Radix Angelicae Pubescentis, Semen Persicae, Radix Achyranthis Bidentatae, Ramulus Cinnamomi, Rhizoma Arisaematis, Radix Aconiti, Radix Aconiti Kusnezoffii medical material, give as one thinks fit cataclasm, with it and more than the same pot of the edible vegetable oil warm macerating 12h, mild and heavy respiration frying is got behind Herba Asari, Herba Ephedrae, Pheretima, the Flos Carthami down again, directly fries to medical material yellow and not withered, filter, waste gets medicine oil, and oil refining is to dripping into pearl;
(2), get Cortex Cinnamomi, Myrrha, Olibanum, Flos Caryophylli powder and be broken into fine powder, with the Borneolum Syntheticum facing-up, sieve mixing;
(3), get Plumbum preparatium and add step (1) the medicine oil that refines, stir, must ointment, ointment is soaked in the cold water, poison puts a chimney on the stove and make the fire draw;
(4), get the poison back ointment that puts a chimney on the stove and make the fire draw, after the slow fire fusing, temper, in the time of below fire to 80 ℃, add the mixing fine powder of step (2), stir, share on cloth, make the plaster finished product.
Prescription tissue of the present invention is reasonable, and rigorous and scientific is effective Chinese medicine preparation.Daphne giraldii Nitsche suffering, hardship, temperature, expelling wind and removing dampness, the pain relieving dissipating blood stasis, the dispelling the wind and dampness pathogens arthralgia pain, numb limbs and tense tendons is the wet key medicine of treatment wind and cold, biography among the people has saying of " painful as completely to climb, as to be unable to do without Daphne giraldii Nitsche ".Be our monarch drug.Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis have cold expelling, expelling wind and dampness, the effect of pain relieving.Radix Aconiti, Radix Aconiti Kusnezoffii property are hot, dredge rapidly sharply, open the pass natural fibre line of meat, and the expulsion cold-damp is good at expelling wind and dampness, and dispelling cold by warming the meridian, analgesic effect are the good merchantable brand of treatment anemofrigid-damp arthralgia more so.The Radix Angelicae Dahuricae, Herba Asari have the effect of pain relieving.All medicines share, and help Daphne giraldii Nitsche expelling wind and removing dampness cold expelling altogether, are ministerial drug.Pathogen usually intruding into collateral in protracted disease, stagnation of blood stasis increases the weight of arthralgia pain, and Gu Zuo has promoting blood circulation to restore menstrual flow with Flos Carthami suffering temperature, the effect of stasis-dispelling and pain-killing, " book on Chinese herbal medicine converges and says ": " medicine of accent blood is also for Flos Carthami, removing blood stasis promoting the circulation of blood, and blood." Semen Persicae is bitter sweet flat, has the effect of blood circulation promoting and blood stasis dispelling.The regulating menstruation of the hot temperature compensation blood of Radix Angelicae Sinensis, promoting blood circulation and stopping pain is the key medicine of promoting blood circulation and stopping pain, cures mainly the wind and cold arthralgia pain, numb limbs and tense tendons.The Radix Paeoniae Rubra bitter cold, the Liver Channel blood system has the merit of promoting blood circulation to remove blood stasis pain relieving.The arduous temperature of Olibanum, Myrrha is arduous flat, the blood-activating and qi-promoting pain relieving, detumescence and promoting granulation, two product sufferings are loose and are walked to scurry, and bitter in the mouth is removed heat by catharsis, and has both gone into blood system, the stagnation of QI in the energy promoting the circulation of blood, blood-activating analgetic." book on Chinese herbal medicine converges and says ": " medicine of muscles and tendons relaxing to alleviate pain also for Olibanum, promoting blood circulation by removing wind." " Records of Tradition Chinese and Western Medicine in Combination ": " key medicine of the meridians that circulate is so all pain of all heart stomach flank limbs joints all can be controlled it for Olibanum Myrrha two medicines and with being the logical internal organs of a surname, circulation internal organs." the bitter sweet acid of Radix Achyranthis Bidentatae is flat, and the blood circulation promoting and blood stasis dispelling tonifying liver and kidney and strengthening bones and muscles is arranged, hold concurrently can wind-damp dispelling effect. our compatibility is precise and appropriate, and medicine is concentrated one's efforts grand, makes unguentum and is affixed on the affected part, through sick institute, treating both the principal and secondary aspects of a disease, easy to use, real is wind-damp dispelling, stopping numbness pain, the good merchantable brand of exterior-applied prescription.
Medicine of the present invention has wind-evil dispelling and cold-evil expelling, and the effect of relaxing muscles and tendons to promote blood circulation cures mainly bones and muscles pain, numb limbs and tense tendons, lumbocrural pain, Fengshi Guanjie swell and ache and the muscles and bones strain, and pain behind the traumatic injury, fiber crops, as all diseases of isocyanides and heating arranged, the a large amount of perspiration, pale complexion, the symptom such as lose weight, after the clinical practice, effect is rapid, and effect is remarkable, has no adverse reaction.
The invention will be further described below by the specific embodiment and pharmacodynamic study result.
The specific embodiment
Embodiment 1
Get Daphne giraldii Nitsche 120g, Radix Angelicae Sinensis 75g, Radix Paeoniae Rubra 75g, Rhizoma Cyperi 75g, Rhizoma Et Radix Notopterygii 75g, Rhizoma Atractylodis Macrocephalae 75g, Radix Saposhnikoviae 75g, Radix Angelicae Dahuricae 75g, Radix Angelicae Pubescentis 75g, Semen Persicae 75g, Radix Achyranthis Bidentatae 75g, Ramulus Cinnamomi 30g, Rhizoma Arisaematis 18g, Radix Aconiti 18g, Radix Aconiti Kusnezoffii 25g, all give cataclasm, be put in the 4.8kg edible vegetable oil, warm macerating 13h, the mild and heavy respiration frying, get Herba Asari 75g, Herba Ephedrae 18g again, Pheretima 18g, Flos Carthami 25g are lowered to subsequently, treat that medical material frying is to yellow and after not withered, 100 mesh sieves filter, waste, get medicine oil, oil refining is to dripping into pearl; Get Cortex Cinnamomi 35g, Myrrha 11g, Olibanum 11g, Flos Caryophylli 8g pulverizes, and with Borneolum Syntheticum 3.5g facing-up, sieves, and mixing gets fine powder; (the alseodaphne hainanensis ratio is red 300～420g) 1540g of every 1000ml vegetable oil, in the time of oily warm near 300 ℃, adds stirring, and reaction is even, gets ointment, and ointment is soaked in the malicious 24h that puts a chimney on the stove and make the fire draw in the cold water to get Plumbum preparatium; Get the poison cream that puts a chimney on the stove and make the fire draw, temper with the slow fire fusing, when temperature is lower than 80 ℃, add fine powder, stir, the stand is applied on the cloth, makes plaster 8kg of the present invention.
Embodiment 2
Get Daphne giraldii Nitsche 125g, Radix Angelicae Sinensis 80g, Radix Paeoniae Rubra 75g, Rhizoma Cyperi 75g, Rhizoma Et Radix Notopterygii 80g, Rhizoma Atractylodis Macrocephalae 75g, Radix Saposhnikoviae 75g, Radix Angelicae Dahuricae 75g, Radix Angelicae Pubescentis 80g, Semen Persicae 75g, Radix Achyranthis Bidentatae 75g, Ramulus Cinnamomi 30g, Rhizoma Arisaematis 18g, Radix Aconiti 18g, Radix Aconiti Kusnezoffii 25g, all give cataclasm, be positioned in the 4.8kg edible vegetable oil, warm macerating 15h, the mild and heavy respiration frying, get Herba Asari 76g, Herba Ephedrae 18g again, Pheretima 18g, Flos Carthami 26g are lowered to subsequently, treat that the medical material frying is to yellow and not withered, 100 mesh sieves filter, waste, get medicine oil, oil refining is to dripping into pearl; Get Cortex Cinnamomi 40g, Myrrha 12g, Olibanum 12g, Flos Caryophylli 9g pulverizes and Borneolum Syntheticum 3.8g facing-up, sieves, and mixing gets fine powder; Get Plumbum preparatium (the alseodaphne hainanensis ratio is every 1000ml vegetable oil with red 300～420g) 1560g,, adds and stirs during to 300 ℃ in the oil temperature, react completely, ointment, ointment is soaked in the malicious 38h that puts a chimney on the stove and make the fire draw in the cold water; Get the poison cream that puts a chimney on the stove and make the fire draw, temper, when temperature is lower than 80 ℃, add fine powder with the slow fire fusing; Stir, the stand is applied on the cloth, makes plaster 8kg of the present invention.
Pharmacodynamic study
The present invention is to provide a kind of natural drug for the treatment of rheumatic arthritis and traumatic injury pain, for proving its therapeutic effect, the unguentum (hereinafter referred to as the Daphne giraldii Nitsche rheumatism plaster) that the method that the inventor uses to be provided by the foregoing description prepares has carried out pharmacodynamics test, and result of the test is as follows:
1. test objective
Observe of the effect of Daphne giraldii Nitsche rheumatism plaster to aspects such as adjuvant-induced arthritis, experimental foot swelling and analgesias thereof.
2. test material
2.1 be subjected to reagent thing Daphne giraldii Nitsche rheumatism plaster, be the pitchy unguentum, every net weight 8.0g is provided by Shanxi Kangyi Pharmaceutical Co., Ltd., lot number 0311503.Clinical usage and dosage is: get one and paste Daphne giraldii Nitsche rheumatism plaster 8.0g, heating sticks in the part after softening, and every 5d changes once, and 15d is a course of treatment.Press 60kg people and calculate, Coming-of-Age Day dosage be 0.027g/ (kgd).
2.2 the positive drug dog skin plaster is the black unguentum, every net weight 15.0g, Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd, lot number: 2210009.Clinical usage and dosage is: get one and paste 15.0g of dog skin plaster, heating sticks in the part after softening, and every 5d changes once, and 15d is a course of treatment.Press 60kg people and calculate, Coming-of-Age Day dosage be 0.05g/ (kgd).
2.3 other drug and reagent Freund ' s Freund's complete adjuvant (U.S. Sigma company), formaldehyde (Shijiazhuang City Organic Chemical Plant, lot number 20040210), (every milliliter contains penicillin 800u for potassium penicillin G and streptomycin sulfate mixed liquor, streptomycin 650u), histamine (the beautiful pearl east wind in Shanghai Bioisystech Co., Ltd, lot number 9712191), Evans indigo plant etc.
2.4 animal Wistar rat, body weight 180 ± 20g is provided by Mountain Western Medicine S University's Experimental Animal Center, and the quality certification number is No. the 070101st, the moving word of doctor.Tried rat and begun test after one week at the experiment indoor feeding.Used calibrated bolck material is provided by Mountain Western Medicine S University's Experimental Animal Center.Healthy adult Kunming mouse, age in days are 45d, and body weight is 18～22g, are provided by Mountain Western Medicine S University's Experimental Animal Center, and quality certification book number is moved No. the 070102nd, word for the doctor.Water 8h is can't help in fasting before the administration of general filling stomach (ig).
2.5 experimental apparatus BS110 type electronic balance (German Sartorius company), TU-1800 type ultraviolet-uisible spectrophotometer (the general all purpose instrument company limited of analysing in Beijing), 501 type ultrathermostats (Shanghai City experimental apparatus factory), self-control rat paw plethysmometer, stopwatch, intervalometer, disposable syringe etc.
3. method and result
3.1 animal-use drug dosage designs low, the high dose of setting Daphne giraldii Nitsche rheumatism plaster animal-use drug in this test and is respectively 0.5g and 1.0g.Setting dog skin plaster animal-use drug amount is 1.0g.
3.2 the statistical method result of the test is represented with x ± s, with the SPSS statistical software each group result is carried out variance analysis relatively; Check the relatively significance of each group difference with grouping t, compare the significance of administration front and back difference with paired t-test.
3.3 effect to adjuvant-induced arthritis
3.3.1 influence to the adjuvant arthritis rats primary affection
50 of male Wistar rats, body weight 180～200g is divided into 5 groups at random, 10 every group.Be respectively normal control group (normal group): local coating vaseline 0.5g; Model control group (model group): local coating vaseline 0.5g; Low, the high dose group of Daphne giraldii Nitsche rheumatism plaster: Daphne giraldii Nitsche rheumatism plaster 0.5g and 1.0g are heated sticks in the part after softening respectively.Dog skin plaster group (positive drug control group): dog skin plaster 1.0g sticks in the part after heating and softening.(top has side pipe, contains the aqueous solution of neutral detergent for glass plethysmometer internal diameter 2.5cm, long 6cm, and liquid level is near the side pipe lower edge to measure not medication front foot sole of the foot volume.Do a labelling with marking pen around the rat hindlimb ankle joint, container is immersed on the rat right side or left hind, make labelling and liquid level overlapping, excess liquid is overflowed from side pipe.Take out rat hindlimb, as seen liquid level descends in the glass container, its decline volume is sufficient sole of the foot volume), only give the right back sufficient sole of the foot intradermal injection normal saline 0.1ml/ of rats in normal control group behind the 30min, all the other are respectively organized right back sufficient sole of the foot intradermal injection Freund ' the s Freund's complete adjuvant 0.1ml/ of rat and only cause inflammation.Each organizes the corresponding thing that tried of the following application in the right back ankle of rat joint, cause the 18h cleaning of scorching back and respectively tried thing, measure rat with method and cause scorching parapodum sole of the foot volume, so that sufficient sole of the foot difference in volume is swelling degree (Δ ml) before and after scorching, the significance of swelling degree difference between the t check is relatively respectively organized between group, and be calculated as follows inhibitory rate of intumesce.
Result's (table 1) is to compare the 18h foot obvious swelling of pawl (P＜0.01) of model group rat adjuvant injection back with the normal control group.Compare with model group, Daphne giraldii Nitsche rheumatism plaster 0.5g and 1.0g and dog skin plaster 1.0g part stick the swelling degree (P＜0.05) that can significantly suppress adjuvant and cause scorching parapodum pawl, and the inhibitory rate of intumesce of 18h is respectively 30.6%, 36.9% and 33.3%.
Table 1 Daphne giraldii Nitsche rheumatism plaster is to the influence of adjuvant arthritis rats constitutional paw swelling
| Group | Dosage (g) | n | Cause scorching back 18h paw swelling | |
| (Δml) | Suppression ratio (%) | |||
| Normal group model group Daphne giraldii Nitsche rheumatism plaster low dose group Daphne giraldii Nitsche rheumatism plaster high dose group dog skin plaster group | 0.5 1.0 1.0 | 10 10 10 10 10 | 0.13±0.14 1.11±0.28 b 0.77±0.33 bc 0.70±0.36 bd 0.74±0.37 bc | 30.6 36.9 33.3 |
aP＜0.05,
bCompare with normal group P＜0.01;
cP＜0.05,
d(grouping t check) compared in P＜0.01 with model group.
3.3.2 effect to the adjuvant arthritis rats secondary affection
Rat beginning in the 7th day behind injection adjuvant among the experiment 3.3.1, apply or stick the corresponding thing that tried with method to the following position of the left and right hind leg ankle joint of each group rat, once a day, every subsides 8h, continuous 20d, different time is removed and is tried thing at interval, measure after the warm water wash residue and cause inflammation parapodum sole of the foot volume, calculate swelling degree (Δ ml), observe incidence rate, the tuberosity number of forelimb, afterbody, ear's pathological changes simultaneously, and the polyarthritis order of severity is marked by the Pyatyi standard: 0: do not have red and swollen; 1: little toe joint is swollen slightly; 2: toe joint and pedal swelling; 3: the following foot swelling of ankle joint; 4: comprise the whole sufficient pawl swelling of ankle joint.Except that causing scorching side, the integration sum of three foots is the joint total mark, is up to 12 fens.Claim body weight in the experimentation weekly one time, put to death animal after the drug withdrawal, claim thymus, spleen weight, calculate organ index (mg/100g body weight).
The result is, compare with the normal control group, the model group rat began to occur secondary reactions on the 12nd day in causing scorching back, mainly show as injection adjuvant offside (left hind) pedal swelling, the red and swollen incidence rate 100% of forelimb joint part has point-like tuberosity projection, erythema appears in 30% animal ear, the about 5mm of diameter, 90% animal afterbody nodosity shape projection is beading.Model group animal left hind swollen joint expansibility, the scoring of Secondary cases pathological changes all are significantly higher than normal control group (P＜0.01, table 2,3).Compare with model group, Daphne giraldii Nitsche rheumatism plaster 0.5g and 1.0g and the dog skin plaster 1.0g 20d of local application can significantly suppress adjuvant arthritis rats injection adjuvant offside swelling degree of the paw, reduce Secondary cases pathological changes total mark (P＜0.05, table 2,3), and significantly suppress the incidence rate of forelimb, afterbody, ear's pathological changes, and except that having 10% animal, low dose group occurs the forelimb redness, and all the other animals all do not have the performance of Secondary cases polyarthritis.Each organizes rat body weight, thymus, spleen organ coefficient there are no significant difference (P＞0.05, table 4).
Table 2 Daphne giraldii Nitsche rheumatism plaster is to the influence of adjuvant arthritis rats Secondary cases paw swelling
| Group | Dosage (g) | n | Cause scorching back different time paw swelling (Δ ml) | ||
| 12d | 19d | 26d | |||
| Normal group model group girald daphne bark plaster for curing rheumatism low dose group girald daphne bark plaster for curing rheumatism high dose group Goupi Gao Zu | 0.5 1.0 1.0 | 10 10 10 10 10 | 0.08±0.10 0.63±0.21 b 0.45±0.22 bc (28.6) 0.41±0.23 bd (34.9) 0.44±0.11 bc (30.2) | 0.11±0.12 1.02±0.35 b 0.71±0.33 bc (30.4) 0.63±0.28 bd (38.2) 0.70±0.36 bc (31.4) | 0.07±0.11 0.88±0.21 b 0.54±0.24 bd (38.6) 0.44±0.25 bd (50.0) 0.52±0.14 bd (40.9) |
aP＜0.05,
bCompare with normal group P＜0.01;
cP＜0.05,
d(grouping t check) compared in P＜0.01 with model group.Data are inhibitory rate of intumesce (%) in the bracket.
Table 3 Daphne giraldii Nitsche rheumatism plaster is to the influence of adjuvant arthritis rats polyarthritis
| Group | Dosage (g) | n | Cause the different time joint scoring of scorching back | ||
| 12d | 19d | 26d | |||
| Normal group | 10 | 0.7±0.7 | 0.7±0.8 | 0.5±0.7 | |
| Model group Daphne giraldii Nitsche rheumatism plaster low dose group Daphne giraldii Nitsche rheumatism plaster high dose group dog skin plaster group | 0.5 1.0 1.0 | 10 10 10 10 | 5.6±2.0 b 3.9±1.2 bc 3.1±1.8 bd 4.1±1.3 bc | 10.1±2.1 b 7.2±2.1 bd 6.5±2.2 bd 6.7±3.0 bd | 8.7±2.0 b 5.3±1.6 bd 4.0±1.4 bd 5.0±1.9 bd |
aP＜0.05,
bCompare with normal group P＜0.01;
cP＜0.05,
d(grouping t check) compared in P＜0.01 with model group.
Table 4 Daphne giraldii Nitsche rheumatism plaster is to the influence of adjuvant arthritis rats body weight and thymus, spleen organ coefficient
| Group | Dosage (g) | n | Body weight (g) | Thymus (mg/100g body weight) | Spleen (mg/100g body weight) | |
| Before the medicine | Behind the medicine | |||||
| Normal group model group Daphne giraldii Nitsche rheumatism plaster low dose group Daphne giraldii Nitsche rheumatism plaster high dose group dog skin plaster group | 0.5 1.0 1.0 | 10 10 10 10 10 | 194±10 197±8 195±9 195±11 197±8 | 295±11 294±9 295±17 293±11 290±10 | 197±23 198±30 202±28 201±17 200±34 | 225±37 230±33 219±26 235±31 228±38 |
Difference that relatively there are no significant between each group (P＞0.05, grouping t check).
3.4 PARA FORMALDEHYDE PRILLS(91,95) causes the influence of rat paw edema effect
40 of male Wistar rats, body weight 180～200g is divided into 4 groups at random, 10 every group.Matched group: local coating vaseline 0.5g; Low, the high dose group of Daphne giraldii Nitsche rheumatism plaster: Daphne giraldii Nitsche rheumatism plaster 0.5g and 1.0g are heated sticks in the part after softening respectively.Dog skin plaster group (positive drug control group): dog skin plaster 1.0g sticks in the part after heating and softening.Measure with volumetric method and respectively to organize the right back sufficient sole of the foot volume of rat before causing inflammation, only cause inflammation to the right back sufficient sole of the foot intradermal injection 2.5% formalin 0.1ml/ of each group rat then.Vola coating or stick medication under the rat right hind leg ankle joint as stated above immediately behind the injection formaldehyde, certain hour is removed and is tried thing at interval, survey sufficient sole of the foot volume with method after the warm water wash residue, totally 5 times, so that sufficient difference in volume is swelling degree (Δ ml) before and after scorching, and calculating inhibitory rate of intumesce, the relatively significance of each group difference.
Table 5 is the result show, there are tangible antiinflammatory action in Daphne giraldii Nitsche rheumatism plaster 0.5g and 1.0g local application, and the maximal percentage inhibition of rat paw edema is respectively 40.4% and 42.6% due to the PARA FORMALDEHYDE PRILLS(91,95).
Table 5 Daphne giraldii Nitsche rheumatism plaster PARA FORMALDEHYDE PRILLS(91,95) causes the influence of rat paw edema
| Group | Dosage (g) | n | Cause scorching back different time paw swelling (Δ ml) | ||||
| 6h | 24h | 48h | 72h | 96h | |||
| Matched group Daphne giraldii Nitsche rheumatism plaster low dose group Daphne giraldii Nitsche rheumatism plaster high dose group dog skin plaster group | 0.5 1.0 1.0 | 10 10 10 10 | 0.84±0.14 0.66±0.10 b (21.4) 0.60±0.17 b (28.6) 0.63±0.14 b (25.0) | 0.92±0.09 0.70±0.18 b (23.9) 0.63±0.18 b (31.5) 0.72±0.12 b (21.7) | 0.85±0.09 0.62±0.22 b (27.1) 0.58±0.14 b (31.8) 0.65±0.16 b (23.5) | 0.62±0.12 0.44±0.18 a (29.0) 0.40±0.16 b (35.5) 0.41±0.19 b (33.9) | 0.47±0.19 0.28±0.13 b (40.4) 0.27±0.10 b (42.6) 0.32±0.12 a (31.9) |
aP＜0.05,
b(grouping t check) compared in P＜0.01 with matched group.Data are inhibitory rate of intumesce (%) in the bracket.
3.5 Ovum Gallus domesticus album is caused the influence of rat paw edema effect
40 of male Wistar rats, body weight 180～200g is divided into 4 groups at random, 10 every group.Grouping is all same with 3.4 with medication.Cause scorching preceding mensuration and respectively organize the right back sufficient sole of the foot volume of rat, only cause inflammation for then the right back sufficient sole of the foot intradermal injection 100% fresh Ovum Gallus domesticus album 0.1ml/ of rat with volumetric method.Apply or stick the corresponding thing that tried, 1h, 2h behind the injection Ovum Gallus domesticus album immediately at the following vola of rat right hind leg ankle joint position, 3h removes and is tried thing, so that each surveys once sufficient sole of the foot volume, totally 3 times with method, so that sufficient difference in volume is swelling degree (Δ ml) before and after scorching, the record result, and calculate inhibitory rate of intumesce.
Table 6 is the result show, Daphne giraldii Nitsche rheumatism plaster 0.5g, and 1.0g local application can significantly suppress Ovum Gallus domesticus album and cause rat paw edema effect (P＜0.05), and maximal percentage inhibition is respectively 57.7% and 67.8%.
Table 6 Daphne giraldii Nitsche rheumatism plaster causes the influence of rat paw edema to Ovum Gallus domesticus album
| Group | Dosage (g) | n | Cause scorching back different time paw swelling (Δ ml) | ||
| 1h | 2h | 3h | |||
| Matched group Daphne giraldii Nitsche rheumatism plaster low dose group Daphne giraldii Nitsche rheumatism plaster high dose group | 0.5 1.0 | 10 10 10 | 0.71±0.16 0.48±0.17 a (32.4) 0.29±0.20 b (59.2) | 0.59±0.36 0.26±0.18 b (55.9) 0.19±0.17 b (67.8) | 0.26±0.19 0.11±0.12 a (57.7) 0.09±0.12 a (65.4) |
| The dog skin plaster group | 1.0 | 10 | 0.38±0.33 b (46.5) | 0.21±0.13 b (64.4) | 0.12±0.10 a (53.8) |
aP＜0.05,
b(grouping t check) compared in P＜0.01 with matched group.Data are inhibitory rate of intumesce (%) in the bracket.
3.6 analgesic activity
3.6.1 effect to rat mechanicalness pain
40 of Wistar rats, body weight 180～200g is divided into 4 groups at random, and 10 every group, male female half and half.Grouping and administrated method are with 3.4.The following vola of each treated animal right hind ankle joint position applies or sticks the corresponding thing that tried, and measures the threshold of pain behind the 6h.Method is: the rustless steel needle point of diameter 2mm is fixed on the syringe piston pommel, the syringe other end is connected to plug-in type hydrargyrum manometer, needle point vertically is pressed in rat right hind leg foot pad position, till progressively constant speed increase pressure to animal shouts, record pressure (kPa) at this moment is as the threshold of pain, and t checks the relatively diversity of the threshold of pain between each group between group.
Table 7 Daphne giraldii Nitsche rheumatism plaster causes the effect of pain to rat machinery
| Group | Dosage (g) | n | The threshold of pain (kPa) |
| Matched group Daphne giraldii Nitsche rheumatism plaster low dose group Daphne giraldii Nitsche rheumatism plaster high dose group dog skin plaster group | 0.5 1.0 1.0 | 10 10 10 10 | 1.71±0.67 4.09±1.75 h 5.56±2.10 b 5.09±2.42 b |
b(grouping t check) compared in P＜0.01 with matched group.
Result's (table 7) is that with the matched group comparison, the Daphne giraldii Nitsche rheumatism plaster is low, the 6h of high dose group local application can significantly improve rat tenderness threshold value (P＜0.01).
3.6.2 effect to the mice hot plate method threshold of pain
Adopt 501 type ultrathermostats control water bath with thermostatic control temperature to be 55 ± 1 ℃ and carry out the hot plate experiment.Laboratory temperature is controlled at about 15 ℃.Mice is placed on 55 ℃ the aluminium sheet, licking metapedes with mice is the pain reaction index.Select pain sensation threshold value 40 of the ♀ of 5～30s mices, be divided into 4 groups at random.Be respectively matched group: two hind leg volas position coating vaseline 0.5g; Low, the high dose group of Daphne giraldii Nitsche rheumatism plaster: Daphne giraldii Nitsche rheumatism plaster 0.5g and 1.0g are heated sticks in two hind leg volas position after softening respectively.Dog skin plaster group (positive drug control group): dog skin plaster 1.0g sticks in two hind leg volas position after heating and softening.Mice is fixed in the little rat holder, and the following vola of two hind leg ankle joint position applies or sticks medication, removes behind the 6h and is tried thing, measures the threshold of pain once more.The threshold of pain＞60s is by 60s.Compare the diversity of the threshold of pain, administration front and back with paired t-test, the diversity of the threshold of pain between the t check is relatively respectively organized between group.
Table 8 result shows, difference that there are no significant in each preceding threshold of pain of treated animal medicine.Pain threshold is respectively 29.9 ± 4.7s and 36.3 ± 8.1s behind the low and high dose group mice medicine of Daphne giraldii Nitsche rheumatism plaster, than significant prolongation before the medicine (P＜0.01), and is significantly higher than matched group (P＜0.05).
Table 8 Daphne giraldii Nitsche rheumatism plaster is to the influence of the mice hot plate method threshold of pain
| Group | Dosage (g) | n | The preceding threshold of pain of medicine (s) | The threshold of pain behind the medicine (s) |
| Matched group Daphne giraldii Nitsche rheumatism plaster low dose group Daphne giraldii Nitsche rheumatism plaster high dose group dog skin plaster group | 0.5 1.0 1.0 | 10 10 10 10 | 22.2±5.9 24.5±5.1 21.8±6.9 23.1±6.1 | 23.3±4.9 29.9±4.7 af 36.3±8.1 bcf 31.1±7.5 ae |
aP＜0.05,
bCompare with matched group P＜0.01;
cP＜0.05,
d(grouping t check) compared in P＜0.01 with the Daphne giraldii Nitsche low dose group;
eP＜0.05,
fP＜0.01 is with comparison (paired t-test) before the medicine.
4. brief summary
This experimental result shows that the Daphne giraldii Nitsche rheumatism plaster has good anti-adjuvant-induced arthritis effect; Rat paw edema due to PARA FORMALDEHYDE PRILLS(91,95) and the Ovum Gallus domesticus album has the obvious suppression effect; The Daphne giraldii Nitsche rheumatism plaster causes pain to rat pressure the significance inhibitory action, and can significantly improve the burning pain threshold value of mice.These experimental result prompting Daphne giraldii Nitsche rheumatism plaster have effects such as good antiinflammatory, analgesia.
Claims (3)
1, a kind of medicine for the treatment of rheumatic arthritis and traumatic injury pain is characterized in that it is the medicament of being made by the following weight proportion raw material:
Daphne giraldii Nitsche 12～13 Radix Angelicae Sinensis 7.5～8.0 Radix Paeoniae Rubra 7.5～8.0 Rhizoma Cyperis 7.5～8.0
Rhizoma Et Radix Notopterygii 7.5～8.5 Herba Asaris 7.5～7.8 Rhizoma Atractylodis Macrocephalaes 7.5～8.0 Radix Saposhnikoviaes 7.5～8.0
The Radix Angelicae Dahuricae 7.5～8.1 Radix Angelicae Pubescentiss 7.5～8.1 Semen Persicaes 7.5～8.1 Radix Achyranthis Bidentataes 7.5～8.1
Cortex Cinnamomi 3.0～4.5 Ramulus Cinnamomi 3.0～4.0 Rhizoma Arisaematiss 1.8～2.0 Herba Ephedraes 1.8～2.1
Pheretima 1.8～2.1 Radix Aconitis 1.8～2.0 Radix Aconiti Kusnezoffii 2.5～2.8 Flos Carthamis 2.5～3.0
Olibanum 1.1～1.5 Myrrhas 1.1～1.5 Borneolum Syntheticums 0.3～0.5 Flos Caryophylli 0.6～1.0.
2, the medicine of treatment rheumatic arthritis according to claim 1 and traumatic injury pain is characterized in that described medicament is a plaster.
3, the preparation method of the medicine of described treatment rheumatic arthritis of claim 2 and traumatic injury pain may further comprise the steps:
(1), gets Daphne giraldii Nitsche, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Cyperi, Rhizoma Et Radix Notopterygii, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Radix Angelicae Pubescentis, Semen Persicae, Radix Achyranthis Bidentatae, Ramulus Cinnamomi, Rhizoma Arisaematis, Radix Aconiti, Radix Aconiti Kusnezoffii medical material, give as one thinks fit cataclasm, with it and more than the same pot of the edible vegetable oil warm macerating 12h, mild and heavy respiration frying is got behind Herba Asari, Herba Ephedrae, Pheretima, the Flos Carthami down again, directly fries to medical material yellow and not withered, filter, waste gets medicine oil, and oil refining is to dripping into pearl;
(2), get Cortex Cinnamomi, Myrrha, Olibanum, Flos Caryophylli powder and be broken into fine powder, with the Borneolum Syntheticum facing-up, sieve mixing;
(3), get Plumbum preparatium and add step (1) the medicine oil that refines, stir, must ointment, ointment is soaked in the cold water, poison puts a chimney on the stove and make the fire draw;
(4), get the poison back ointment that puts a chimney on the stove and make the fire draw, after the slow fire fusing, temper, in the time of below fire to 80 ℃, add the mixing fine powder of step (2), stir, share on cloth, make the plaster finished product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934012A (en) * | 2010-08-16 | 2011-01-05 | 山西康意制药有限公司 | Gel ointment for treating rheumatic arthritis and traumatic injury |
| CN107243042A (en) * | 2017-08-15 | 2017-10-13 | 刘元 | Chinese medicine composition for analgesic and its preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186694A (en) * | 1998-01-06 | 1998-07-08 | 李韶雪 | Pain relieving ointment and its preparing method |
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2005
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934012A (en) * | 2010-08-16 | 2011-01-05 | 山西康意制药有限公司 | Gel ointment for treating rheumatic arthritis and traumatic injury |
| CN107243042A (en) * | 2017-08-15 | 2017-10-13 | 刘元 | Chinese medicine composition for analgesic and its preparation method and application |
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| CN100363037C (en) | 2008-01-23 |
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