CN1739618A - Heart disease treating Chinese medicine prepn and its prepn process and quality control method - Google Patents
Heart disease treating Chinese medicine prepn and its prepn process and quality control method Download PDFInfo
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- CN1739618A CN1739618A CNA2005100321130A CN200510032113A CN1739618A CN 1739618 A CN1739618 A CN 1739618A CN A2005100321130 A CNA2005100321130 A CN A2005100321130A CN 200510032113 A CN200510032113 A CN 200510032113A CN 1739618 A CN1739618 A CN 1739618A
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Abstract
The Chinese medicine preparation for treating heart diseases is prepared with musk, ginseng extract, bozoar, cassia, toad cake and other two kinds of Chinese medicinal materials as main materials and may be prepared into dripping pill, dispersant tablet or soft capsule. The preparation process includes extracting volatile oil with cassia and crushing, grinding four of the Chinese medicinal materials into fine powder, mixing, adding supplementary material, and other steps to prepare dripping pill, dispersant tablet or soft capsule. The quality control method is content measurement. The preparation has high product quality stability, high curative effect, etc.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof and method of quality control, relate in particular to cardiopathic Chinese medicine preparation of a kind of treatment and preparation method thereof and method of quality control.
Background technology:
Drop pill in the Chinese medicine preparation or dispersible tablet or soft capsule, change dosage form or technology and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The existing dosage form of this product is a ball, has listed the state-promulgated pharmacopoeia standard in.
Chinese patent CN1363286 discloses nano musk medicine for protecting heart and preparation method thereof; CN1650999 discloses a kind of musk heart protecting oral cavity disintegrating tablet and preparation method thereof; Do not see the patent and the document of relevant Moschus guarantor's heart drop pill or dispersible tablet or soft capsule.
The technology features of existing Heart pill of Musk is to get Moschus, Radix Ginseng extract, Calculus Bovis, Cortex Cinnamomi, Styrax, Venenum Bufonis, Borneolum Syntheticum medical material, is ground into fine powder, sieves mixing.Powder adds refined honey and makes big honeyed pills, promptly.
Existing Heart pill of Musk has bioavailability low, and produce effects is slow, shortcoming such as is difficult for taking.
Summary of the invention:
The purpose of this invention is to provide cardiopathic Chinese medicine preparation of a kind of treatment and preparation method thereof and method of quality control, overcome the above-mentioned drawback of prior art, improve quality, curative effect, the bioavailability of product, satisfy the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
The cardiopathic Chinese medicine preparation of a kind of treatment, it is that main constituent is Moschus guarantor's heart drop pill or the dispersible tablet or the soft capsule of Moschus, Radix Ginseng extract, Calculus Bovis, Cortex Cinnamomi, Styrax, Venenum Bufonis, Borneolum Syntheticum.
Its preparation method is:
(1) medicine constituent and percentage by weight thereof are as follows:
Moschus, Borneolum Syntheticum, Radix Ginseng extract, Calculus Bovis each 4～7%, Styrax, Venenum Bufonis each 15～35%, Cortex Cinnamomi 20～40%; Medicine constituent optimum weight percentage ratio is:
Moschus, Borneolum Syntheticum, Radix Ginseng extract, Calculus Bovis each 5.88%, Styrax, Venenum Bufonis each 23.53%, Cortex Cinnamomi 29.42%;
(2) get Moschus, Borneolum Syntheticum, Radix Ginseng extract, Calculus Bovis, Venenum Bufonis and be ground into fine powder respectively, mixing gets mixing fine powders;
(3) get the Cortex Cinnamomi distillating extracting oil, the device collection is standby in addition for the aqueous solution after the distillation, and volatile oil is standby; The gained medicinal residues carry out percolation, be made into 30～70% ethanol with the aqueous solution after the distillation of gained and make solvent, dipping a few hours earlier, with the speed of per minute 2～3ml percolation slowly, collect the liquid of filtering, reclaim ethanol, the liquid of filtering concentrates, drying is pulverized, fine powder is standby;
(4) get (2) gained mixing fine powders and add the Styrax mix homogeneously, get the hybrid medicine fine powder with (3) gained fine powder, standby;
(5) get (4) gained hybrid medicine fine powder, spray into the Cortex Cinnamomi volatile oil of (3) gained, get hybrid medicine; With one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other suitable adjuvant, use with by arbitrary proportion, add above-mentioned gained hybrid medicine after being heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70～100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, coolant is use up and removed to the drop pill drop of molding, dry, coating or coating not promptly get drop pill.
(6) get the hybrid medicine fine powder of (4) gained, add appropriate amount of auxiliary materials, mix homogeneously is granulated, dry, granulate, sprays into the Cortex Cinnamomi volatile oil of (3) gained, is pressed into dispersible tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci.
(7) get the hybrid medicine fine powder of (4) gained, spray into the Cortex Cinnamomi volatile oil of (3) gained, add suitable adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule.
Adjuvant is one or more combinations or other suitable adjuvant of following material, uses with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween.
The preparation method that its Moschus is protected heart dispersible tablet can also be:
(1) medicine constituent and percentage by weight thereof are as follows:
Moschus, Borneolum Syntheticum, Radix Ginseng extract, Calculus Bovis each 4～7%, Styrax, Venenum Bufonis each 15～35%, Cortex Cinnamomi 20～40%;
Medicine constituent optimum weight percentage ratio is:
Moschus, Borneolum Syntheticum, Radix Ginseng extract, Calculus Bovis each 5.88%, Styrax, Venenum Bufonis each 23.53%, Cortex Cinnamomi 29.42%;
(2) above seven flavors, except that Styrax, Six-elements such as all the other Moschus are ground into fine powder altogether, it is an amount of to add Styrax again, drying, hybrid medicine, standby;
(3) get the hybrid medicine of (2) gained, add appropriate amount of auxiliary materials, mix homogeneously, granulation, dry, granulate are pressed into dispersible tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci.
A kind of method of quality control for the treatment of cardiopathic Chinese medicine preparation is that it is the method for quality control that Moschus is protected heart drop pill or dispersible tablet or soft capsule:
Assay, the content of cinnamic acid in the mensuration Styrax, according to high effective liquid chromatography for measuring, chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica; Get methanol-water-glacial acetic acid (45～60: 45～60: 0.1～0.5) be mobile phase; Detect wavelength 230～260nm; Theoretical cam curve is calculated by the cinnamic acid peak should be no less than 2000;
It is an amount of that the preparation of reference substance solution, precision take by weighing the cinnamic acid reference substance, adds diethyl ether to make the solution that every 1ml contains 0.1～0.3mg, in contrast product solution;
The preparation of free cinnamic acid need testing solution, precision takes by weighing this product 0.1～1g, uses ether dissolution, the extraction of 2～6% sodium bicarbonate aqueous solutions, combining extraction liquid, the hydrochloric acid acid adjustment, extracted with diethyl ether reclaims ether, and methanol constant volume is to 10ml, and is standby;
The preparation of total cinnamic acid need testing solution, precision takes by weighing this product 0.5～5g, puts in the tool plug conical flask, add 0.5mol/L alcohol hydrogen manufacturing potassium oxide 20～30ml, put the 0.5～2h that refluxes in the water-bath, decompression recycling ethanol, residue adds hot water 40～60ml to be made it to be uniformly dispersed, and cooling adds water 70～90ml and Adlerika (1.5 → 50) 40～60ml, mixing, leave standstill 5～15min, filter, filtering residue washs with low amounts of water, merge washing liquid and filtrate, add hydrochloric acid and make it acidity, extracted with diethyl ether, combined ether layer, and recovery ethanol, residue also is dissolved in the 50ml volumetric flask surely with dissolve with methanol, and precision is drawn 1～3ml in the 10ml volumetric flask, methanol constant volume, shake up, standby;
Algoscopy, accurate respectively reference substance solution and each 5～10ul of need testing solution of drawing injects chromatograph of liquid, measures.
Specific embodiments:
The present invention further specifies in conjunction with specific embodiments, can be for reference, do not limit the scope of the invention:
The cardiopathic Chinese medicine preparation of a kind of treatment, it is that main constituent is Moschus guarantor's heart drop pill or the dispersible tablet or the soft capsule of Moschus, Radix Ginseng extract, Calculus Bovis, Cortex Cinnamomi, Styrax, Venenum Bufonis, Borneolum Syntheticum.
The cardiopathic Chinese medicine preparation of a kind of treatment of the present invention can aromatic herbs activating YANG, invigorate vital energy and reinforce the heart.Be mainly used in the thoracic obstruction of caused by energy stagnation and blood stasis, disease is seen precordialgia, fixes and does not move; Angina pectoris due to the myocardial ischemia, myocardial infarction are seen above-mentioned patient.
Cardiopathic Chinese medicine preparation drop pill of a kind of treatment of the present invention or dispersible tablet or soft capsule preparation method are:
(1) medicine constituent and weight consumption are as follows:
Moschus, Borneolum Syntheticum, Radix Ginseng extract, each 5g of Calculus Bovis, Styrax, each 20g of Venenum Bufonis, Cortex Cinnamomi 25g;
(2) get Moschus, Borneolum Syntheticum, Radix Ginseng extract, Calculus Bovis, Venenum Bufonis and be ground into fine powder respectively, mixing gets mixing fine powders;
(3) get the Cortex Cinnamomi distillating extracting oil, the device collection is standby in addition for the aqueous solution after the distillation, and volatile oil is standby; The gained medicinal residues carry out percolation, be made into 50% ethanol with the aqueous solution after the distillation of gained and make solvent, dipping a few hours earlier, with the speed of per minute 2～3ml percolation slowly, collect the liquid of filtering, reclaim ethanol, the liquid of filtering concentrates, drying is pulverized, fine powder is standby;
(4) get (2) gained mixing fine powders and add the Styrax mix homogeneously, get the hybrid medicine fine powder with (3) gained fine powder, standby;
(5) the cardiopathic Chinese medicine preparation drop pill of a kind of treatment is that Moschus is protected heart drop pill, and its preparation method is a hybrid medicine fine powder of getting (4) gained, sprays into the Cortex Cinnamomi volatile oil of (3) gained, and mix homogeneously gets hybrid medicine; With Polyethylene Glycol PEG6000 105g, stearic acid 36g, Poloxamer188 20g, treat that Polyethylene Glycol PEG6000, stearic acid, Poloxamer188 are heated to the hybrid medicine that adds above-mentioned gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, by splashing in the liquid paraffin, be condensed into ball at heat-retaining condition, to the greatest extent and the erasing liquor paraffin body with the drop pill drop of molding, cold drying promptly gets drop pill.
(6) the cardiopathic Chinese medicine preparation dispersible tablet of a kind of treatment is that Moschus is protected heart dispersible tablet, its preparation method is a hybrid medicine fine powder of getting (4) gained, adding cross-linking polyethylene pyrrolidone 20g, low-substituted hydroxypropyl cellulose 30g, microcrystalline cellulose 64g are ground into fine powder, make wetting agent with ethanol, 20 mesh sieves are granulated, 65 ℃ of dryings, granulate, spray into the Cortex Cinnamomi volatile oil of (3) gained, add micropowder silica gel 1g mixing, tabletting, promptly.
(7) the cardiopathic Chinese medicine preparation soft capsule of a kind of treatment is that Moschus is protected soft-hearted capsule, its preparation method is a hybrid medicine fine powder of getting (4) gained, add water and make suspension, the adding adjuvant is the combination of one or more different proportions in PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, the tween, spray into the Cortex Cinnamomi volatile oil of (3) gained, suppress or drip and make soft capsule.
(8) the cardiopathic Chinese medicine preparation dispersible tablet of a kind of treatment is that Moschus is protected heart dispersible tablet, and its preparation method is:
1. medicine constituent and weight consumption are as follows:
Moschus, Borneolum Syntheticum, Radix Ginseng extract, each 5g of Calculus Bovis, Styrax, each 20g of Venenum Bufonis, Cortex Cinnamomi 25g;
2. above seven flavors, except that Styrax, Six-elements such as all the other Moschus are ground into fine powder altogether, add in right amount with Styrax, and drying gets hybrid medicine, and is standby;
3. get the 2. hybrid medicine of gained, adding cross-linking polyethylene pyrrolidone 10g, low-substituted hydroxypropyl cellulose 15g, microcrystalline cellulose 30g are ground into fine powder, make wetting agent with ethanol, 20 mesh sieves are granulated, and 65 ℃ of dryings, granulate add micropowder silica gel 1g mixing, tabletting, promptly.
A kind of method of quality control for the treatment of cardiopathic Chinese medicine preparation, it is the method for quality control that Moschus is protected heart drop pill or dispersible tablet or soft capsule:
Assay, the content of cinnamic acid in the mensuration Styrax, according to high effective liquid chromatography for measuring, chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica; Get methanol-water-glacial acetic acid (50: 50: 0.2) and be mobile phase; Detect wavelength 253nm; Theoretical cam curve is calculated by the cinnamic acid peak should be no less than 2000;
It is an amount of that the preparation of reference substance solution, precision take by weighing the cinnamic acid reference substance, adds diethyl ether to make the solution that every 1ml contains 0.2mg, in contrast product solution;
The preparation of free cinnamic acid need testing solution, precision takes by weighing this product 0.6g, uses ether dissolution, the extraction of 5% sodium bicarbonate aqueous solution, combining extraction liquid, the hydrochloric acid acid adjustment, extracted with diethyl ether reclaims ether, and methanol constant volume is to 10ml, and is standby;
The preparation of total cinnamic acid need testing solution, precision takes by weighing this product 2g, puts in the tool plug conical flask, add 0.5mol/L alcohol hydrogen manufacturing potassium oxide 25ml, put the 1h that refluxes in the water-bath, decompression recycling ethanol, residue adds hot water 50ml to be made it to be uniformly dispersed, and cooling adds water 80ml and Adlerika (1.5 → 50) 50ml, mixing, leave standstill 10min, filter, filtering residue washs with low amounts of water, merge washing liquid and filtrate, add hydrochloric acid and make it acidity, extracted with diethyl ether, combined ether layer, and recovery ethanol, residue also is dissolved in the 50ml volumetric flask surely with dissolve with methanol, and precision is drawn 2ml in the 10ml volumetric flask, methanol constant volume, shake up, standby;
Algoscopy, accurate respectively reference substance solution and each 5ul of need testing solution of drawing injects chromatograph of liquid, measures.
Advantage of the present invention is:
Take, easy to carry, constant product quality is conducive to improve drug effect.
Claims (6)
1, the cardiopathic Chinese medicine preparation of a kind of treatment is characterized in that it is that main constituent is Moschus guarantor's heart drop pill or the dispersible tablet or the soft capsule of Moschus, Radix Ginseng extract, Calculus Bovis, Cortex Cinnamomi, Styrax, Venenum Bufonis, Borneolum Syntheticum.
2, a kind of preparation method for the treatment of cardiopathic Chinese medicine preparation, it is that Moschus is protected heart drop pill or dispersible tablet or preparation of soft capsule method, it is characterized in that:
(1) medicine constituent and percentage by weight thereof are as follows:
Moschus, Borneolum Syntheticum, Radix Ginseng extract, Calculus Bovis each 4～7%, Styrax, Venenum Bufonis each 15～35%, Cortex Cinnamomi 20～40%;
(2) get Moschus, Borneolum Syntheticum, Radix Ginseng extract, Calculus Bovis, Venenum Bufonis and be ground into fine powder respectively, mixing gets mixing fine powders;
(3) get the Cortex Cinnamomi distillating extracting oil, the device collection is standby in addition for the aqueous solution after the distillation, and volatile oil is standby; The gained medicinal residues carry out percolation, be made into 30～70% ethanol with the aqueous solution after the distillation of gained and make solvent, dipping a few hours earlier, with the speed of per minute 2～3ml percolation slowly, collect the liquid of filtering, reclaim ethanol, the liquid of filtering concentrates, drying is pulverized, fine powder is standby;
(4) get (2) gained mixing fine powders and add the Styrax mix homogeneously, get the hybrid medicine fine powder with (3) gained fine powder, standby;
(5) get (4) gained hybrid medicine fine powder, spray into the Cortex Cinnamomi volatile oil of (3) gained, hybrid medicine, add suitable adjuvant after, make drop pill or dispersible tablet or soft capsule;
The preparation method of its drop pill is: with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other suitable adjuvant, use with by arbitrary proportion, be heated to the hybrid medicine that adds (5) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70～100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, coolant is use up and removed to the drop pill drop of molding, dry, coating or coating not promptly get drop pill;
The preparation method of its dispersible tablet is: get the hybrid medicine fine powder of (4) gained, add appropriate amount of auxiliary materials, mix homogeneously is granulated, dry, granulate, sprays into the Cortex Cinnamomi volatile oil of (3) gained, is pressed into dispersible tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci;
Its preparation of soft capsule method is: get the hybrid medicine fine powder of (4) gained, spray into the Cortex Cinnamomi volatile oil of (3) gained, add suitable adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more combinations or other suitable adjuvant of following material, uses with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween.
3, a kind of preparation method for the treatment of cardiopathic Chinese medicine preparation according to claim 2, it is characterized in that by adding suitable adjuvant, other any pharmaceutically useful dosage forms be can make, sheet (plain sheet, coated tablet, Film coated tablets, enteric coatel tablets, effervescent tablet, slow-release tablet, fast-release tablet), capsule, enteric coated capsule, slow, controlled release capsule, ball, micropill, enteric coated micropill, pellet capsule, granule, effervescent granule, oral liquid, injection etc. comprised.
4, a kind of preparation method for the treatment of cardiopathic Chinese medicine preparation according to claim 2 is characterized in that the preparation method of Moschus guarantor heart dispersible tablet also can be:
(1) medicine constituent and percentage by weight thereof are as follows:
Moschus, Borneolum Syntheticum, Radix Ginseng extract, Calculus Bovis each 4～7%, Styrax, Venenum Bufonis each 15～35%, Cortex Cinnamomi 20～40%;
(2) above seven flavors, except that Styrax, Six-elements such as all the other Moschus are ground into fine powder, it is an amount of to add Styrax again, drying, hybrid medicine, standby;
(3) get the hybrid medicine of (2) gained, add appropriate amount of auxiliary materials, mix homogeneously, granulation, dry, granulate are pressed into dispersible tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci.
5, a kind of method of quality control for the treatment of cardiopathic Chinese medicine preparation, it is the method for quality control that Moschus is protected heart drop pill or dispersible tablet or soft capsule, it is characterized in that:
Assay, the content of cinnamic acid in the mensuration Styrax, according to high effective liquid chromatography for measuring, chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica; Get methanol-water-glacial acetic acid (45～60: 45～60: 0.1～0.5) be mobile phase; Detect wavelength 230～260nm; Theoretical cam curve is calculated by the cinnamic acid peak should be no less than 2000;
It is an amount of that the preparation of reference substance solution, precision take by weighing the cinnamic acid reference substance, adds diethyl ether to make the solution that every 1ml contains 0.1～0.3mg, in contrast product solution;
The preparation of free cinnamic acid need testing solution, precision takes by weighing this product 0.1～1g, uses ether dissolution, the extraction of 2～6% sodium bicarbonate aqueous solutions, combining extraction liquid, the hydrochloric acid acid adjustment, extracted with diethyl ether reclaims ether, and methanol constant volume is to 10ml, and is standby;
The preparation of total cinnamic acid need testing solution, precision takes by weighing this product 0.5～5g, puts in the tool plug conical flask, add 0.5mol/L alcohol hydrogen manufacturing potassium oxide 20～30ml, put the 0.5～2h that refluxes in the water-bath, decompression recycling ethanol, residue adds hot water 40～60ml to be made it to be uniformly dispersed, and cooling adds water 70～90ml and Adlerika (1.5 → 50) 40～60ml, mixing, leave standstill 5～15min, filter, filtering residue washs with low amounts of water, merge washing liquid and filtrate, add hydrochloric acid and make it acidity, extracted with diethyl ether, combined ether layer, and recovery ethanol, residue also is dissolved in the 50ml volumetric flask surely with dissolve with methanol, and precision is drawn 1～3ml in the 10ml volumetric flask, methanol constant volume, shake up, standby;
Algoscopy, accurate respectively reference substance solution and each 5～10ul of need testing solution of drawing injects chromatograph of liquid, measures.
6, a kind of preparation method for the treatment of cardiopathic Chinese medicine preparation according to claim 2 is characterized in that the optimum weight percentage ratio of its main constituent is:
Moschus, Borneolum Syntheticum, Radix Ginseng extract, Calculus Bovis each 5.88%, Styrax, Venenum Bufonis each 23.53%, Cortex Cinnamomi 29.42%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100321130A CN1739618A (en) | 2005-09-06 | 2005-09-06 | Heart disease treating Chinese medicine prepn and its prepn process and quality control method |
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| CNA2005100321130A CN1739618A (en) | 2005-09-06 | 2005-09-06 | Heart disease treating Chinese medicine prepn and its prepn process and quality control method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102486472A (en) * | 2009-04-20 | 2012-06-06 | 上海和黄药业有限公司 | Method for determining medicine active component in serum |
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2005
- 2005-09-06 CN CNA2005100321130A patent/CN1739618A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102486472A (en) * | 2009-04-20 | 2012-06-06 | 上海和黄药业有限公司 | Method for determining medicine active component in serum |
| CN102486472B (en) * | 2009-04-20 | 2015-11-25 | 上海和黄药业有限公司 | A kind of method measuring medicine active component in serum |
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