CN1679780A - Chinese medicine preparation for treating gynecopathy, preparation and quality control thereof - Google Patents
Chinese medicine preparation for treating gynecopathy, preparation and quality control thereof Download PDFInfo
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- CN1679780A CN1679780A CN 200510031233 CN200510031233A CN1679780A CN 1679780 A CN1679780 A CN 1679780A CN 200510031233 CN200510031233 CN 200510031233 CN 200510031233 A CN200510031233 A CN 200510031233A CN 1679780 A CN1679780 A CN 1679780A
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Abstract
A Chinese medicine in the form of capsule, softgel, dripping pill, or dispersing tablet for treating gynopathy is proportionally prepared from 8 Chinese-medicinal materials including honeysuckle stem, motherwort, red peony root, Chuan-xiong rhizome, etc. Its preparing process and quality control method are also disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof and method of quality control, relate in particular to gynopathic Chinese medicine preparation of a kind of treatment and preparation method thereof and method of quality control.
Background technology:
Capsule in the Chinese medicine preparation or soft capsule or drop pill or dispersible tablet, change dosage form and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The existing dosage form of this product is a granule, has listed the national drug ministry standard in.
The technology features of the gynopathic Chinese medicine granules of existing treatment is that the prescription medical material is decocted with water secondary, each 2 hours, merging filtrate filtered, it is 1.25 (90 ℃) that filtrate is concentrated into relative density, add ethanol and make that to contain alcohol amount be 65%, stir evenly, left standstill 12 hours, the leaching supernatant, reclaiming ethanol to relative density is the clear paste of 1.30 (60-65 ℃), adds suitable adjuvant, drying and granulating.The gynopathic Chinese medicine granules of existing treatment exists and need take after mixing it with hot water, and dose is big, and mouthfeel is poor, uses, carries shortcomings such as equal inconvenience.
Summary of the invention:
The purpose of this invention is to provide gynopathic Chinese medicine preparation of a kind of treatment and preparation method thereof and method of quality control, overcome the above-mentioned drawback of prior art, improve the quality and the curative effect of product, bioavailability and controllability and stability satisfy medical needs better.
The present invention seeks to be achieved through the following technical solutions.
It is that main component is capsule or soft capsule or the drop pill or the dispersible tablet of Caulis Lonicerae, Caulis Spatholobi, Rhizoma Cibotii, Herba Taraxaci, Herba Leonuri, Herba Plantaginis, Radix Paeoniae Rubra, Rhizoma Chuanxiong to treat gynopathic Chinese medicine preparation.
Its preparation method is:
(1) medicine constituent and percentage by weight thereof are as follows:
Caulis Lonicerae, Caulis Spatholobi, each 10.7-32.1% of Rhizoma Cibotii, Herba Taraxaci, Herba Leonuri, each 4.3-12.9% of Herba Plantaginis, Radix Paeoniae Rubra, each 2.6-7.7% of Rhizoma Chuanxiong;
The optimum weight percentage ratio of medicine constituent is: Caulis Lonicerae, Caulis Spatholobi, Rhizoma Cibotii each 21.4%, Herba Taraxaci, Herba Leonuri, Herba Plantaginis each 8.6%, Radix Paeoniae Rubra, Rhizoma Chuanxiong each 5.1%.
(2) above eight flavor pulverizing medicinal materials are become fine powder, decoct with water secondary, each 2 hours, collecting decoction, filter, filtrate is concentrated into the thick paste that relative density is 1.25 (90 ℃), adds ethanol and makes that to contain the alcohol amount be 65%, stir evenly, left standstill 12 hours, and got supernatant, reclaiming ethanol to relative density is the thick paste of 1.30 (60～65 ℃), or be dried to dried cream, standby;
(3) get the medicine thick paste or the dried cream of (2) gained, do not add adjuvant or add adjuvant, mix homogeneously is granulated drying; The granule branch Capsules of packing into promptly gets capsule;
Adjuvant is one or more combinations of following material: lactose, starch, carboxymethyl starch sodium, pregelatinized Starch, sucrose, glucose, mannitol, sorbitol, syrup, microcrystalline Cellulose, methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxypropyl emthylcellulose, low-substituted hydroxypropyl cellulose, carboxymethylcellulose calcium, calcium sulfate, calcium hydrogen phosphate, calcium phosphate, calcium carbonate, light magnesium oxide, Pulvis Talci, micropowder silica gel, aluminium hydroxide, boric acid, sodium chloride, dextrin, magnesium stearate, hydrogenated vegetable oil, Polyethylene Glycol;
(4) get the medicine thick paste or the dried cream of (2) gained, behind water dissolution, do not add adjuvant or add adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more combinations of following material: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween;
(5) with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamerl88, use with by arbitrary proportion, add (2) prepared medicine thick paste or dried cream after being heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in liquid coolant liquid paraffin or methyl-silicone oil or vegetable oil or water or the ethanol by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly gets drop pill;
(6) get the medicine thick paste or the dried cream of (2) gained, do not add adjuvant or add adjuvant, mix homogeneously, granulation, dry, granulate add colloidality silicon dioxide, the combination of one or more different proportions in magnesium stearate, the Pulvis Talci, mix homogeneously is pressed into dispersible tablet;
Adjuvant is one or more combinations of following material: low-substituted hydroxypropyl cellulose, the swollen shallow lake 5000 of dimension, polyvinylpolypyrrolidone 1NF-10, Polyethylene Glycol, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid.
The method of quality control of the medicine that makes is: get this medicine porphyrize, get 1-5g, add methanol 20-40ml, reflux 10-60 minute, filter, filtrate is put evaporate to dryness in the water-bath, residue adds water 5-50ml makes dissolving, put in the separatory funnel, add the ethyl acetate extraction secondary, each 5-50ml, merge ethyl acetate liquid, put evaporate to dryness in the water-bath, residue adds ethyl acetate 0.5-2ml makes dissolving, as need testing solution; Other gets Rhizoma Cibotii control medicinal material 0.5-2g, adds water 20-80ml, boils 10-50 minute, puts cold, filter, filtrate adds the ethyl acetate extraction secondary, and each 5-40ml merges ethyl acetate liquid, put evaporate to dryness in the water-bath, residue adds ethyl acetate 0.5-2ml makes dissolving, in contrast medical material solution; Test according to thin layer chromatography, draw each 2-20 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with cyclohexane extraction-ethyl acetate-formic acid (2-8: 1-5: 0.05-2) be developing solvent, launch, take out, dry, spray is with the acid ferric chloride alcoholic solution of 1-9% hydrochloric acid, put 80-150 ℃ dry by the fire to the speckle colour developing clear; In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color;
Get this medicine, porphyrize is got 1-5g, add methanol 20-40ml, reflux 10-60 minute, filter, filtrate is put evaporate to dryness in the water-bath, and residue adds water 5-40ml makes dissolving, puts in the separatory funnel, add chloroform and extract secondary, each 5-40ml, combined chloroform liquid is put evaporate to dryness in the water-bath, residue adds chloroform 0.5-2ml makes dissolving, as need testing solution; Other gets Herba Taraxaci control medicinal material 1-5g, shines medical material solution in pairs with legal system; According to thin layer chromatography test, draw each 5-20 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, be developing solvent with the chloroform, launch, take out, dry, spray 5-20% ethanol solution of sulfuric acid, put 80-150 ℃ dry by the fire to the speckle colour developing clear; In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color;
Assay is according to high effective liquid chromatography for measuring; Chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica; With methanol-water (11-33: 67-89) be mobile phase; The detection wavelength is 180-280nm; Theoretical cam curve is calculated by peoniflorin should be not less than 1500; The preparation of reference substance solution, it is an amount of to get the peoniflorin reference substance, adds methanol and makes the solution that contains 0.02-0.1mg among every 1ml, promptly; This product is got in the preparation of need testing solution, and accurate the title decides, porphyrize is got the about 0.1-0.5g of fine powder, and accurate the title decides, put in the tool plug triangular flask, the accurate methanol 10-50ml that adds claims to decide weight, supersound process (power 200W, frequency 40KHz) 20-60 minute is put cold, add methanol and supply the weight that subtracts mistake, shake up, filter, get subsequent filtrate, promptly; Algoscopy, accurate respectively reference substance solution and each 5ul of need testing solution of drawing injects chromatograph of liquid, measures, promptly.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
Treating gynopathic Chinese medicine preparation is that main component is capsule or soft capsule or the drop pill or the dispersible tablet of Caulis Lonicerae, Caulis Spatholobi, Rhizoma Cibotii, Herba Taraxaci, Herba Leonuri, Herba Plantaginis, Radix Paeoniae Rubra, Rhizoma Chuanxiong.
Chinese medicine preparation of the present invention is mainly used in treatment damp invasion of lower energizer, leukorrhagia.
The preparation method of Chinese medicine preparation of the present invention is:
(1) its medicine constituent and weight consumption thereof are as follows:
Caulis Lonicerae, Caulis Spatholobi, each 1250g of Rhizoma Cibotii, Herba Taraxaci, Herba Leonuri, each 500g of Herba Plantaginis, Radix Paeoniae Rubra, each 300g of Rhizoma Chuanxiong.
(2) get (1) Chinese medicine and decoct with water secondary, each 2 hours, collecting decoction filtered, filtrate is concentrated into the thick paste that relative density is 1.25 (90 ℃), add ethanol and make that to contain alcohol amount be 65%, stir evenly, left standstill 12 hours, get supernatant, reclaiming ethanol to relative density is the thick paste of 1.30 (60～65 ℃), or is dried to dried cream, standby.
(3) the capsular preparation method of Chinese medicine preparation of the present invention is to get (2) gained thick paste 280g, add starch: the mixed accessories 125g of micropowder silica gel (3: 2), mixing, (60-70 ℃ of vacuum drying, vacuum is 0.07-0.09Mpa), be ground into fine powder, add the about 45g of an amount of mixed accessories again and adjust total amount to 450g, mixing is made 1000 altogether; The granule branch is packed in the Capsules, promptly.
(4) Chinese medicine preparation preparation of soft capsule method of the present invention is to get (2) gained thick paste 280g, adds water and makes dissolving, and it is an amount of to add PEG4000, and mix homogeneously is made the l000 grain, suppresses or drips and make soft capsule.
(5) preparation method of Chinese medicine preparation drop pill of the present invention is to get (2) gained thick paste 280g, Polyethylene Glycol PEG6000 280g, stearic acid 56g, Poloxamerl88 28g, treat to add (2) gained medicine after Polyethylene Glycol PEG6000, stearic acid, Poloxamerl88 are heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, under heat-retaining condition, go in the liquid paraffin by dropping-pill machine, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly.
(6) preparation method of Chinese medicine preparation dispersible tablet of the present invention is to get (2) gained thick paste 280g, add dimension swollen shallow lake P5000 896g polyvinylpolypyrrolidone INF-10 672g, PEG6000 560g and PEG4000 560g mix homogeneously, behind granulation, drying, the granulate, the colloidality silicon dioxide mix homogeneously that added 100 mesh sieves, tabletting, promptly.
The method of quality control of Chinese medicine preparation of the present invention is:
Get this medicine porphyrize, get 3g, add methanol 30ml, reflux 30 minutes filters, and filtrate is put evaporate to dryness in the water-bath, residue adds water 20ml makes dissolving, put in the separatory funnel, add the ethyl acetate extraction secondary, each 20ml, merge ethyl acetate liquid, put evaporate to dryness in the water-bath, residue adds ethyl acetate 1ml makes dissolving, as need testing solution; Other gets Rhizoma Cibotii control medicinal material 1g, adds water 50ml, boils 30 minutes, puts coldly, filters, and filtrate adds the ethyl acetate extraction secondary, and each 20ml merges ethyl acetate liquid, puts evaporate to dryness in the water-bath, and residue adds ethyl acetate 1ml makes dissolving, in contrast medical material solution; Test according to thin layer chromatography, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with cyclohexane extraction-ethyl acetate-formic acid (5: 3: 0.1) is developing solvent, launch, take out, dry, spray is with the acid ferric chloride alcoholic solution of 5% hydrochloric acid, put 105 ℃ dry by the fire to the speckle colour developing clear; In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color;
Get this medicine, porphyrize is got 3g, add methanol 30ml, reflux 30 minutes filters, filtrate is put evaporate to dryness in the water-bath, and residue adds water 20ml makes dissolving, puts in the separatory funnel, add chloroform and extract secondary, each 20ml, combined chloroform liquid, put evaporate to dryness in the water-bath, residue adds chloroform 1ml makes dissolving, as need testing solution, other gets Herba Taraxaci control medicinal material 2g, shine medical material solution in pairs with legal system,, draw each 10 μ l of above-mentioned two kinds of solution according to the thin layer chromatography test, put respectively on same silica gel g thin-layer plate, with the chloroform is developing solvent, launches, and takes out, dry, spray 10% ethanol solution of sulfuric acid, put 105 ℃ dry by the fire to speckle colour developing clear, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color;
Assay is according to high effective liquid chromatography for measuring; Chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica; With methanol-water (22: 78) is mobile phase; The detection wavelength is 230nm; Theoretical cam curve is calculated by peoniflorin should be not less than 1500; The preparation of reference substance solution, it is an amount of to get the peoniflorin reference substance, adds methanol and makes the solution that contains 0.06mg among every 1ml, promptly; This product is got in the preparation of need testing solution, and accurate the title decides, porphyrize is got the about 0.25g of fine powder, and accurate the title decides, put in the tool plug triangular flask, the accurate methanol 25ml that adds claims to decide weight, supersound process (power 200W, frequency 40KHz) 40 minutes is put cold, add methanol and supply the weight that subtracts mistake, shake up, filter, get subsequent filtrate, promptly; Algoscopy, accurate respectively reference substance solution and each 5ul of need testing solution of drawing injects chromatograph of liquid, measures, promptly.
Advantage of the present invention is:
Carry, taking convenience, do not have bad smell, the bioavilability height, controllability and good stability are conducive to improve Curative effect.
Claims (4)
1, the gynopathic Chinese medicine preparation of a kind of treatment is characterized in that it is that main component is capsule or soft capsule or the drop pill or the dispersible tablet of Caulis Lonicerae, Caulis Spatholobi, Rhizoma Cibotii, Herba Taraxaci, Herba Leonuri, Herba Plantaginis, Radix Paeoniae Rubra, Rhizoma Chuanxiong.
2, a kind of preparation method for the treatment of gynopathic Chinese medicine preparation is characterized in that:
(1) medicine constituent and consumption percentage by weight thereof are as follows:
Caulis Lonicerae, Caulis Spatholobi, each 10.7-32.1% of Rhizoma Cibotii, Herba Taraxaci, Herba Leonuri, each 4.3-12.9% of Herba Plantaginis, Radix Paeoniae Rubra, each 2.6-7.7% of Rhizoma Chuanxiong;
(2) above eight flavor pulverizing medicinal materials are become fine powder, decoct with water secondary, each 2 hours, collecting decoction, filter, filtrate is concentrated into the thick paste that relative density is 1.25 (90 ℃), adds ethanol and makes that to contain alcohol amount be 65%, stirs evenly, left standstill 12 hours, get supernatant, reclaiming ethanol to relative density is the thick paste of 1.30 (60～65 ℃), or it is standby to make dried cream; After gained thick paste or dried cream added suitable adjuvant, mixing was made capsule or soft capsule or drop pill or dispersible tablet;
Capsular preparation method is: get prepared medicine thick paste or dried cream, do not add adjuvant or add adjuvant, mix homogeneously is granulated drying; The granule branch Capsules of packing into promptly gets capsule;
Adjuvant is one or more combinations of following material: lactose, starch, carboxymethyl starch sodium, pregelatinized Starch, sucrose, glucose, mannitol, sorbitol, syrup, microcrystalline Cellulose, methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxypropyl emthylcellulose, low-substituted hydroxypropyl cellulose, carboxymethylcellulose calcium, calcium sulfate, calcium hydrogen phosphate, calcium phosphate, calcium carbonate, light magnesium oxide, Pulvis Talci, micropowder silica gel, aluminium hydroxide, boric acid, sodium chloride, dextrin, magnesium stearate, hydrogenated vegetable oil, Polyethylene Glycol;
The preparation method of soft capsule is: get prepared medicine thick paste or dried cream, behind water dissolution, do not add adjuvant or add adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more combinations of following material: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween;
The preparation method of drop pill is: with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamerl88, use with by arbitrary proportion, add prepared medicine thick paste or dried cream after being heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in liquid coolant liquid paraffin or methyl-silicone oil or vegetable oil or water or the ethanol by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly gets drop pill;
The preparation method of dispersible tablet is: get prepared medicine thick paste or dried cream, do not add adjuvant or add adjuvant, mix homogeneously, granulation, dry, granulate add colloidality silicon dioxide, the combination of one or more different proportions in magnesium stearate, the Pulvis Talci, mix homogeneously is pressed into dispersible tablet;
Adjuvant is one or more combinations of following material: low-substituted hydroxypropyl cellulose, the swollen shallow lake 5000 of dimension, polyvinylpolypyrrolidone 1NF-10, Polyethylene Glycol, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid.
3, a kind of method of quality control for the treatment of gynopathic Chinese medicine preparation is: get this medicine porphyrize, get 1-5g, add methanol 20-40ml, reflux 10-60 minute, filter, filtrate is put evaporate to dryness in the water-bath, residue adds water 5-50ml makes dissolving, put in the separatory funnel, add the ethyl acetate extraction secondary, each 5-50ml, merge ethyl acetate liquid, put evaporate to dryness in the water-bath, residue adds ethyl acetate 0.5-2ml makes dissolving, as need testing solution; Other gets Rhizoma Cibotii control medicinal material 0.5-2g, adds water 20-80ml, boils 10-50 minute, puts cold, filter, filtrate adds the ethyl acetate extraction secondary, and each 5-40ml merges ethyl acetate liquid, put evaporate to dryness in the water-bath, residue adds ethyl acetate 0.5-2ml makes dissolving, in contrast medical material solution; Test according to thin layer chromatography, draw each 2-20 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with cyclohexane extraction-ethyl acetate-formic acid (2-8: 1-5: 0.052) be developing solvent, launch, take out, dry, spray is with the acid ferric chloride alcoholic solution of 1-9% hydrochloric acid, put 80-150 ℃ dry by the fire to the speckle colour developing clear; In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color;
Get this medicine, porphyrize is got 1-5g, add methanol 20-40ml, reflux 10-60 minute, filter, filtrate is put evaporate to dryness in the water-bath, and residue adds water 5-40ml makes dissolving, puts in the separatory funnel, add chloroform and extract secondary, each 5-40ml, combined chloroform liquid, put evaporate to dryness in the water-bath, residue adds chloroform 0.5-2ml makes dissolving, as need testing solution, other gets Herba Taraxaci control medicinal material 1-5g, shines medical material solution in pairs with legal system; According to thin layer chromatography test, draw each 5-20 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, be developing solvent with the chloroform, launch, take out, dry, spray 5-20% ethanol solution of sulfuric acid, put 80-150 ℃ dry by the fire to the speckle colour developing clear; In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color;
Assay is according to high effective liquid chromatography for measuring; Chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica; With methanol-water (11-33: 67-89) be mobile phase; The detection wavelength is 180-280nm; Theoretical cam curve is calculated by peoniflorin should be not less than 1500; The preparation of reference substance solution, it is an amount of to get the peoniflorin reference substance, adds methanol and makes the solution that contains 0.02-0.1mg among every 1ml, promptly; This product is got in the preparation of need testing solution, and accurate the title decides, porphyrize is got the about 0.1-0.5g of fine powder, and accurate the title decides, put in the tool plug triangular flask, the accurate methanol 10-50ml that adds claims to decide weight, supersound process (power 200W, frequency 40KHz) 20-60 minute is put cold, add methanol and supply the weight that subtracts mistake, shake up, filter, get subsequent filtrate, promptly; Algoscopy, accurate respectively reference substance solution and each 5ul of need testing solution of drawing injects chromatograph of liquid, measures.
4, the preparation method of the gynopathic Chinese medicine preparation of treatment according to claim 2 is characterized in that the optimum weight percentage ratio of its main constituent is:
Caulis Lonicerae, Caulis Spatholobi, Rhizoma Cibotii each 21.4%, Herba Taraxaci, Herba Leonuri, Herba Plantaginis each 8.6%, Radix Paeoniae Rubra, Rhizoma Chuanxiong each 5.1%.
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| CN 200510031233 CN1679780A (en) | 2005-02-01 | 2005-02-01 | Chinese medicine preparation for treating gynecopathy, preparation and quality control thereof |
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| CN 200510031233 CN1679780A (en) | 2005-02-01 | 2005-02-01 | Chinese medicine preparation for treating gynecopathy, preparation and quality control thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199602B (en) * | 2007-12-19 | 2011-08-24 | 姚俊华 | Containing medicament soft capsule for treating gynecology disease and preparing method thereof |
| CN102764319A (en) * | 2012-08-13 | 2012-11-07 | 广西康华药业有限责任公司 | Traditional Chinese medicine vagina effervescent tablets for curing cervical erosion of women and preparation method thereof |
| CN103149319A (en) * | 2013-03-05 | 2013-06-12 | 西安碑林药业股份有限公司 | Quality detection method for Chinese herbal preparation with effects of stimulating circulation of blood and causing muscles and joints to relax and activating blood circulation and dissipating blood stasis |
| CN107884489A (en) * | 2017-11-07 | 2018-04-06 | 贵阳德昌祥药业有限公司 | A kind of detection method of Zaizao Pill |
-
2005
- 2005-02-01 CN CN 200510031233 patent/CN1679780A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199602B (en) * | 2007-12-19 | 2011-08-24 | 姚俊华 | Containing medicament soft capsule for treating gynecology disease and preparing method thereof |
| CN102764319A (en) * | 2012-08-13 | 2012-11-07 | 广西康华药业有限责任公司 | Traditional Chinese medicine vagina effervescent tablets for curing cervical erosion of women and preparation method thereof |
| CN103149319A (en) * | 2013-03-05 | 2013-06-12 | 西安碑林药业股份有限公司 | Quality detection method for Chinese herbal preparation with effects of stimulating circulation of blood and causing muscles and joints to relax and activating blood circulation and dissipating blood stasis |
| CN107884489A (en) * | 2017-11-07 | 2018-04-06 | 贵阳德昌祥药业有限公司 | A kind of detection method of Zaizao Pill |
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